43rd week of 2014 patent applcation highlights part 45 |
Patent application number | Title | Published |
20140315253 | ACTIVATED COLLAGEN SCAFFOLD MATERIALS AND THEIR SPECIAL FUSED ACTIVE RESTORATION FACTORS - Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in SEQ ID NO:4 at N-terminus | 2014-10-23 |
20140315254 | CLEAN SUGAR AND LIGNIN FROM NON-CHEMICALLY PRETREATED LIGNOCELLULOSIC BIOMASS - Methods of producing clean (e.g., low sulfur and metal ion content, and free of fermentation inhibitors) sugar and lignin-rich streams, and downstream conversion products, from lignocellulosic biomass, may include obtaining non-chemically pretreated, milled lignocellulosic biomass, reacting the milled lignocellulosic biomass with an enzymatic agent to produce a slurry that includes converted monomeric lignocellulosic sugars and lignin-rich residuals, and separating the slurry into a sugar stream that includes the converted monomeric lignocellulosic sugars and a lignin-rich stream that includes the lignin-rich residuals. The sugar stream, not including water, includes at least 75% monomeric lignocellulosic sugar, less than 0.20% sulfur, and less than 3.0% metal ion content, and the lignin-rich stream includes at least 35% lignin and less than 0.50% sulfur. Some methods include producing fermentation products such as alcohols and/or organic acids from the sugar stream, and/or use of the lignin residuals in fuels. | 2014-10-23 |
20140315255 | NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF - The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject. | 2014-10-23 |
20140315256 | COVER MEMBER, METHOD AND TREATMENT MODULE FOR TREATING A BIOLOGICAL SAMPLE ON A SUBSTRATE - A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member. | 2014-10-23 |
20140315257 | GENE TARGETING VECTOR, METHOD FOR MANUFACTURING SAME, AND METHOD FOR USING SAME - Provided is a gene targeting vector capable of highly efficient gene targeting. | 2014-10-23 |
20140315258 | METHODS FOR CONVERTING CELLULOSIC WASTE TO BIOPRODUCTS - The present invention provides processes for converting cellulosic waste, such as municipal solid waste, to bioproducts such as monosaccharides and fermentation products. | 2014-10-23 |
20140315259 | CELLULOSE CO-FEED FOR DRY MILL CORN ETHANOL OPERATIONS - The present application provide methods for producing ethanol from a biomass. The methods combine sugars produced from a feedstock containing starch with sugars produced from a cellulosic biomass. The methods allow increased amounts of ethanol to be produced from a given solids concentration in the fermenters. The methods also encompass filtering the liquefied feedstock mash through a filter comprising biomass fibers. The biomass filter produces a post-filtered mash stream comprising a high concentration of sugars and a low concentration of non-fermentable solids. The methods provide numerous advantages described herein. | 2014-10-23 |
20140315260 | NOVEL CELLULOSE AND LIGNO-CELLULOSE ACTIVE PROTEINS - Methods to digest carbohydrates, especially lignocelluloses and hemicelluloses, using fungal proteins previously not recognized as having this activity are described. | 2014-10-23 |
20140315261 | METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE FAMILY ENTEROBACTERIACEAE HAVING ATTENUATED EXPRESSION OF THE yjjK GENE - The present invention provides a method for producing L-amino acids by fermentation using a bacterium of the family Enterobacteriaceae, particularly a bacterium belonging to the genus | 2014-10-23 |
20140315262 | PROCESS FOR MAKING HMF AND HMF DERIVATIVES FROM SUGARS, WITH RECOVERY OF UNREACTED SUGARS SUITABLE FOR DIRECT FERMENTATION TO ETHANOL - Hydroxymethylfurfural is made from an aqueous hexose sugar solution, especially from a high fructose corn syrup product. By rapidly heating the sugar solution to the elevated temperatures involved as well as rapidly cooling the resultant product mixture, a limited per-pass conversion to HMF is obtained; correspondingly, however, the overall exposure of the HMF that is formed to acidic, elevated temperature conditions is also limited, so that byproducts are reduced. Separation and recovery of the products is simplified, and levels of HMF and other hexose dehydration products known to inhibit ethanol production by fermentation are reduced in the residual sugars product, to an extent whereby the residual sugars product is suited to be directly fermented to ethanol or for other uses. | 2014-10-23 |
20140315263 | METHOD FOR THE PREPARATION OF NICOTINIC ACID - A method for the preparation of nicotinic acid, which includes the step of obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, and the step of adding an acid to the culture solution and conducting a decarboxylation reaction. | 2014-10-23 |
20140315264 | ENZYME ASSOCIATED WITH EQUOL SYNTHESIS - An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. | 2014-10-23 |
20140315265 | PROCESS OF PRODUCING OIL FROM ALGAE USING BIOLOGICAL RUPTURING - A process for production of biofuels from algae can include cultivating an oil-producing algae, extracting the algal oil, and converting the algal oil to form biodiesel. Extracting the algal oil from the oil-producing algae can include biologically rupturing cell wall and oil vesicles of the oil-producing algae using at least one enzyme such as a cellulose or glycoproteinase, a structured enzyme system such as a cellulosome, a virus, or combination of these materials. | 2014-10-23 |
20140315266 | ACCELERATED PROCESS FOR THE ENERGY CONVERSION OF CARBON DIOXIDE - The present invention relates to a process for the energy conversion of carbon dioxide, comprising the steps of culturing phytoplankton in electromagnetic bioaccelerators, producing oxygen and biomass made up of lipids, hydrocarbons and sugars from the previous step, oxidizing the hydrocarbons produced in the previous step to generate carbon dioxide and NOx and collecting the carbon dioxide and NOx from the previous step until the cultures of the first step. | 2014-10-23 |
20140315267 | Tailored Oils Produced from Recombinant Heterotrophic Microorganisms - Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants. | 2014-10-23 |
20140315268 | METHOD OF PRODUCING BIOFUEL USING SEA ALGAE - The present invention relates to a method of producing biofuel, more specifically a method of producing biofuel comprising the steps of generating monosugars from marine algae, or from polysaccharides extracted from marine algae by treating the marine algae or the polysaccharides with a hydrolytic enzyme and/or a hydrolytic catalyst; and fermenting the monosugars using a microorganism to produce biofuel. The method of producing biofuel of the present invention solve the problem of raw material suppliance since it uses marine algae as a raw material for biomass, and reduce the production costs by excluding lignin eliminating process that has been required by the conventional method using wood-based raw materials, resulting in economic and environmental advantages. | 2014-10-23 |
20140315269 | USE OF RECOMBINANT TYPE III "POLYKETIDE SYNTHASES" (PKS III) OF MARINE BROWN ALGAE - The present invention relates to a method for producing polyphenol compounds, i.e. phloroglucinol or one of its derivatives, with a polyketide synthase of type III (PKSIII) from a brown marine alga. The invention also relates to recombinant nucleic acids coding for a polyketide synthase of type III (PKSIII) from the brown alga | 2014-10-23 |
20140315270 | METHOD FOR ADDING ENZYMES TO OBTAIN HIGH ETHANOL YIELD FROM CEREAL MASH - The present invention generally relates to processes for production of monosaccharides and ethanol from energy crops. In some aspects, the present invention relates to improvements in ethanol production from energy crops including fractionating liquefied mash to generate a fraction enriched in complex polysaccharides such as cellulose, conversion of the cellulosic components to monosaccharides, and preparation of ethanol therefrom. | 2014-10-23 |
20140315271 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam. | 2014-10-23 |
20140315272 | NOVEL LIPOLYTIC ENZYME LIP2 - The present invention provides a novel nucleic acid sequence, designated LIP2, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for producing the same. | 2014-10-23 |
20140315273 | BETA-MANNANASE HAVING IMPROVED ENZYMATIC ACTIVITY - A β-mannanase having increased enzymaic activity is disclosed. The β-mannanase has a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of Tyrosine at position 216 with Tryptophan. | 2014-10-23 |
20140315274 | Methods For Production of Archeae Protease in Yeast - The invention relates to: a method for producing a protease in yeast, comprising providing a yeast host cell comprising at least one polynucleotide expression construct encoding a first polypeptide secreted by the host cell in translational fusion with a second polypeptide, wherein the second polypeptide is a protease having a mature amino acid sequence similar to that of SEQ ID NO:2; the corresponding yeast host cell and the expression construct. | 2014-10-23 |
20140315275 | ISOPRENE SYNTHASE VARIANTS WITH IMPROVED SOLUBILITY FOR PRODUCTION OF ISOPRENE - The present invention provides methods and compositions of variant polypeptides having isoprene synthase activity with improved solubility. In particular, the present invention provides isoprene synthase variant for increased isoprene production in recombinant host cells. | 2014-10-23 |
20140315276 | SYNTHESIS OF LINEAR AND BRANCHED POLYMERS OF POLYPEPTIDES THROUGH DIRECT CONJUGATION - Methods are provided for a one step synthesis of polypeptide polymers or co-polymers. The polymers or co-polymers can be linear or branched. In the methods of the invention, the coding sequence for the polypeptide(s) to be polymerized is altered by introducing one or more codons for an nonnatural amino acid, which coding sequence is then utilized to produce the cognate polypeptide. The nonnatural amino acids are selected to be reactive with each other in a bioorthogonal reaction, and are combined in a conjugation reaction with the desired components of the polymer. | 2014-10-23 |
20140315277 | NOVEL METHOD - The present invention relates to a method for degrading host cell nucleic acids associated with a virus or a viral antigen thereof produced by cell culture, the method comprising at least two steps of nucleic acids degradation with a compound selected from i) an endonuclease and ii) a DNA alkylating agent. | 2014-10-23 |
20140315278 | SPORE SURFACE DISPLAYS OF BIOACTIVE MOLECULES - This invention discloses novel bacterial spore systems. Genetically modified or genetically engineered viable spore systems expressing bioactive polypeptides, for example bacteriocins and/or enzymatically active feed enzymes, at the spore surface, have a great potential use in animal feeding. Genetically modified or “genetically engineered inert spore systems expressing affinity ligands or immobilized enzymes at the surface have a great potential use in biocatalysis and in the construction of biocatalytic films. Especially the resistance to harsh chemicals, desiccation, strong pressure, or high temperatures allows the spores to be a potentially valuable tool for the display of bioactive molecules, like biocatalytic enzymes or bioactive feed enzymes that must survive harsh conditions to deliver their full potential. Finally, instead of translational fusions to spore structural genes, passenger bioactive polypeptides, as for example enzymes, bacteriocins, affinity ligands, can also be fused to spore-specific surface enzymes, for example to spore specific enzymes as mentioned herein above. | 2014-10-23 |
20140315279 | PRODUCTION OF QUINONE DERIVED COMPOUNDS IN OLEAGINOUS YEAST AND FUNGI - The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds. | 2014-10-23 |
20140315280 | METHOD, PHOTOBIOREACTOR AND PHOTOSYNTHESIS LAYERS FOR THE CULTURE OF PHOTOAUTOTROPHIC MICRO-ORGANISMS - A process for cultivation of photoautotrophic microorganisms is proposed comprising
| 2014-10-23 |
20140315282 | MICROINJECTOR MOUNTING MODULE AND NEEDLE-HOLDER COMPONENT - A microinjector needle mounting module and a needle holder assembly, comprising a micro-injection needle ( | 2014-10-23 |
20140315283 | SAMPLE CARTRIDGE AND SAMPLE STAGE - A sample cartridge ( | 2014-10-23 |
20140315284 | ENHANCED DETECTION SENSITIVITY WITH PIEZOELECTRIC MICROCANTILEVER SENSORS - A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enhanced by the application of a DC bias electric field to the piezoelectric layer that enhances non-180° polarization domain switching of the piezoelectric layer. The change in the Young's modulus may also result from binding of the species of interest to the piezelectric microcantilever sensor or a combination of binding and application of a DC bias electric field. Significantly enhanced detection sensitity results from the changed Young's modulus of the piezoelectric layer. | 2014-10-23 |
20140315285 | LIGNOCELLULOSIC DETECTION DEVICE - A lignocellulosic detection device includes a lignocellulosic substrate and at least one detection reagent absorbed/coated to lignocellulosic tissue of the lignocellulosic substrate. A liquid specimen is in contact with the lignocellulosic substrate so as to be absorbed to the lignocellulosic tissue of the lignocellulosic substrate by capillary action and react with the detection reagent to achieve specimen detection. The lignocellulosic detection device of the present invention is provided with inherent advantages of the lignocellulosic substrate such as natural material, low cost, easy manipulation and capillary effect and results in a good preventive diagnosis platform. Also, users may achieve preventive disease diagnosis without spending additional time and/or money. | 2014-10-23 |
20140315286 | Electro Medical Tool Optimization System - Methods and apparatus are disclosed herein to improve on and expand the range of electrical and electromagnetic frequencies used in therapeutic electro medical devices. The present invention uses electrical and electromagnetic frequency generators and detectors integrated with a live cell imaging system that provides feedback to the frequency generators using data derived from said imaging system. | 2014-10-23 |
20140315287 | SYSTEM AND METHOD FOR DEFORMING AND ANALYZING PARTICLES - A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet. The fluidic pathway includes a delivery region configured to receive the plurality of particles from the inlet and focus the plurality of particles from a random distribution to a focused state, a deformation region defining an intersection located downstream of the delivery region and coupled to the outlet, and wherein the deformation region is configured to receive the plurality of particles from the delivery region and to transmit each particle in the plurality of particles into the intersection from a single direction, a first branch fluidly coupled to the deformation region and configured to transmit a first flow into the intersection, and a second branch fluidly coupled to the deformation region and configured to transmit a second flow, substantially opposing the first flow, into the intersection, wherein the first flow and the second flow are configured to induce extension of one or more particles in the plurality of particles. | 2014-10-23 |
20140315288 | PARTICLE ANALYSIS APPARATUS AND PRODUCTION METHOD THEREOF - An apparatus including a flow cell part having a flow channel where a sample solution containing the particles to be analyzed flows; a light irradiation device for irradiating an irradiation light as a beam light to a light irradiation point in the flow channel; and a light receiving device for detecting the light resulting from the irradiation of the beam light to the light irradiation point. The light irradiation device has a light source device and a beam-light-forming-film composed of an opaque film and a light transmitting hole formed in the film. Using the light transmitting hole, the cross sectional shape of the irradiation light is changed to that of the beam light, whereby optical apparatuses such as lens and the like on the irradiation side are omitted. | 2014-10-23 |
20140315289 | DISPOSABLE CARTRIDGE FOR ERYTHROCYTE MECHANICAL FRAGILITY TEST - A disposable cartridge for use in red blood cell mechanical fragility profiling, comprising a stressing section with a lysing chamber in which the sample can receive multiple increments of mechanical stress to cause lysis, and a detection section with a transparent region that at least sometimes can have a thickness suitable to take optical readings that can directly or indirectly reflect a fraction/proportion of cells lysed after each increment of the stress, whereby said region can capture at least a representative portion of the sample that received each increment of stress. In some embodiments, the stressing section and the detection section are the same, and/or the transparent region is flexible or otherwise compressible, and/or the stress is ultrasonic. In some embodiments, the sections are separate, and/or the region is rigid or has a fixed thickness, and/or the stress may comprise cell-to-wall interaction and associated fluidic or viscous shear stress induced via concentric/coaxial objects. | 2014-10-23 |
20140315290 | LOW-COST PHOTOBIOREACTOR - The present invention provides a photobioreactor comprising at least one translucent flexible sheet shapable by a support assembly forming thereby an elongated channel adapted for biomass production therewithin. Kits for making a photobioreactor and a floatable photobioreactor are also provided. | 2014-10-23 |
20140315291 | Solar Conversion System And Methods - Generally, culturing systems and methods for making and using culturing systems. Specifically, photobioreactor systems and methods for making and using photobioreactor systems to culture photosynthetic organisms, such as algae. | 2014-10-23 |
20140315292 | Three Stage, Multiple Phase Anaerobic Digestion System and Method - A three stage, multiple phase anaerobic digestion system and method designed to separate the biological phases, optimize microbial activity in each phase, and significantly increase system reliability and energy production. The system physically separates the biological phases of anaerobic digestion based on particle size, particle density, and solubility of metabolic products. The system allows a complex multi-phased biological system to develop without the need for excessive control or operator intervention. | 2014-10-23 |
20140315293 | MAGNETIC PATTERNING METHOD AND SYSTEM - The present invention relates to a method and apparatus for patterning a substrate. The method comprises providing at least one magnetic pattern generator configured and operable to modulate the magnetic field to induce varying magnetic properties to a magnetic field according to a desired pattern; applying the modulated magnetic field in the vicinity of the substrate creating a certain pattern of regions of interaction to be obtained on top of the substrate; and; interacting the substrate with magnetic particles, while under the application of the modulated magnetic field, the magnetic particles being attracted to selected regions of interaction defined by the certain pattern while being substantially not attracted to regions outside the regions of interaction, thus creating on top of the substrate the certain pattern of regions interacted with the magnetic particles. The desired pattern corresponds to a certain pattern for a predetermined magnetic field profile and at a predetermined distance from the magnetic pattern generator, where the sample is to be located. | 2014-10-23 |
20140315294 | SCALABLE LENTIVIRAL VECTOR PRODUCTION SYSTEM COMPATIBLE WITH INDUSTRIAL PHARMACEUTICAL APPLICATIONS - The present invention relates to the industrialization of the production of recombinant lentiviral vectors in order to manufacture sufficient materials for therapeutic applications such as gene therapy and/or DNA vaccination, for use in clinical trials and/or commercial use. | 2014-10-23 |
20140315295 | POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF - A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells. | 2014-10-23 |
20140315296 | HIGHLY EFFICIENT GAS PERMEABLE DEVICES AND METHODS FOR CULTURING CELLS - This invention relates to methods and devices that improve cell culture efficiency. They include the use of gas permeable culture compartments that reduce the use of space while maintaining uniform culture conditions, and are more suitable for automated liquid handling. They include the integration of gas permeable materials into the traditional multiple shelf format to resolve the problem of non-uniform culture conditions. They include culture devices that use surfaces comprised of gas permeable, plasma charged silicone and can integrate traditional attachment surfaces, such as those comprised of traditional tissue culture treated polystyrene. They include culture devices that integrate gas permeable, liquid permeable membranes. A variety of benefits accrue, including more optimal culture conditions during scale up and more efficient use of inventory space, incubator space, and disposal space. Furthermore, labor and contamination risk are reduced. | 2014-10-23 |
20140315297 | METHOD FOR ISOLATING CELLS AND BIOPARTICLES - The invention relates to a simple and inexpensive method for simultaneous isolation of cells and/or bioparticles from complex fluids that differ in one or more surface properties (e.g. cell sub-populations). For that purpose, the surface of a solid carrier is modified in a manner to be provided with different capture molecules, which allows in an additional step a specifically “neutralizing” of individual target particles. Different target particles with both identical and different recognition structures are to be gradually detached from the capture particles and isolated/separated. Areas of application of the invention are biotechnology (including biological and medical research), diagnosis and treatment of diseases. | 2014-10-23 |
20140315298 | ENGINEERED STEM CELLS AND THEIR THERAPEUTIC USE - The present invention relates to mesenchymal stem cells (MSC) genetically modified to express sST2 or parts thereof for use in the treatment of airway immune inflammatory and lung diseases, wherein said mesenchymal stem cells are not human embryonic stem cells. The present invention also relates to pharmaceutical compositions comprising said mesenchymal stem cells. | 2014-10-23 |
20140315299 | STABLE PROTEINS - The invention provides a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a Family B G-protein coupled receptor (GPCR) that comprises transmembrane helix (TM)-1, TM2 and TM3 of the GPCR; b) a stable protein domain; and c) a second portion of the GPCR comprising TM4, TM5, TM6 and TM7 of the GPCR. The invention also provides a method of crystallising a GPCR comprising providing the fusion protein of the invention and crystallising it to obtain crystals. | 2014-10-23 |
20140315300 | Microcarriers for Stem Cell Culture - We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50 μm and 400 μm, such as about 200 μm. It may have a cross sectional dimension of between 20 μm and 30 μm. The particle may comprise a substantially compact or spherical shaped particle having a size of between about 20 μm and about 120 μm, for example about 65 μm. We also disclose a method of propagating primate or human stem cells, the method comprising: providing first and second primate or human stem cells attached to first and second respective particles, allowing the first primate or human stem cell to contact the second primate or human stem cell to form an aggregate of cells and culturing the aggregate to propagate the primate or human stem cells for at least one passage. A method of propagating human embryonic stem cells (hESCs) in long term suspension culture using microcarriers coated in Matrigel or hyaluronic acid is also disclosed. We also disclose a method for differentiating stem cells. | 2014-10-23 |
20140315301 | ISOLATED NAIVE PLURIPOTENT STEM CELLS AND METHODS OF GENERATING SAME - Provided is an isolated human naive pluripotent stem cell (PSC), wherein: (i) when the naive PSC is a female PSC, then said naive female PSC has two unmethylated alleles of an X-inactive specific transcript (XIST) gene; and (ii) when said naive PSC is a male PSC, then said naive male PSC has an unmethylated allele of said XIST gene. Also provided is a culture medium which comprises an ERK1/2 inhibitor, a GSK3beta inhibitor, a p38 inhibitor, a JNK inhibitor, a STAT3 activator and at least one agent selected from the group consisting of: bFGF, TGFbeta 1, a PKC inhibitor, a ROCK inhibitor and a NOTCH inhibitor; or at least agent selected from the group consisting of: a TGFR inhibitor, a FGFR inhibitor, a PKC inhibitor, a ROCK inhibitor and a NOTCH inhibitor. | 2014-10-23 |
20140315302 | ALIGNED NANOFIBERS AND RELATED METHODS OF USE - The present invention relates to nanofibers. In particular, the present invention provides aligned nanofiber bundle assemblies. In some embodiments, the aligned nanofiber bundle assemblies are used for tissue regeneration, controlled growth of cells, and related methods (e.g., diagnostic methods, research methods, drug screening). | 2014-10-23 |
20140315303 | METHOD AND DEVICE FOR SAMPLE PROCESSING - In accordance with an aspect of the present disclosure there is provided an apparatus for the processing of biological sample. The apparatus comprises a first sheet of material, a second sheet of material bonded to the first sheet of material, and a plurality of chambers defined between the first sheet of material and the second sheet of material, the plurality of chambers including a sample dissociation chamber including an inlet and an outlet; a waste collection chamber including an inlet in fluid communication with the outlet of the sample dissociation chamber, and a cell refinement chamber including an inlet in fluid communication with the sample dissociation chamber and an outlet. | 2014-10-23 |
20140315304 | REPROGRAMMING T CELLS AND HEMATOPOIETIC CELLS - Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34 | 2014-10-23 |
20140315305 | METHOD FOR PRODUCING CORNEAL ENDOTHELIAL CELL - The invention provides a method of efficiently producing corneal endothelial cells, particularly from corneal stroma or iPS cell-derived neural crest stem cells, a method of producing corneal endothelial cells stably in a large amount by inducing more efficient differentiation of stem cells into corneal endothelial cells, and a medicament containing corneal endothelial cells. The method of inducing differentiation of stem cells into corneal endothelial cells includes a step of culturing the stem cells in a differentiation induction medium containing a GSK3 inhibitor (preferably a GSK3β inhibitor) and retinoic acid, with the differentiation induction medium preferably further containing one or more of TGFb2, insulin, a ROCK inhibitor, and the like. | 2014-10-23 |
20140315306 | CELL CULTURE SUBSTRATE COMPRISING A LAMININ AND A CADHERIN - The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells. When pluripotent human embryonic stem cells are cultured on plates coated with recombinant laminin-521 (laminin-11), in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferate and maintain their pluripotency. It has also been discovered that human recombinant laminin-521 (laminin-11) provides single cell survival of stem cells after complete dissociation into a single cell suspension. Useful cell culture mediums containing at most 3.9 ng/ml of beta fibroblast growth factor (bFGF) are also described herein. | 2014-10-23 |
20140315307 | MIXED POPULATION OF CELLS DERIVING FROM ADIPOSE TISSUE AND METHODS OF ISOLATING AND USING THE SAME - Adipose tissue-derived stromal cells and methods of isolating and using the same. In at least one embodiment of isolated adipose tissue-derived stromal cells of the present disclosure, the cells are isolated by performing adipose tissue resection or suction on a mammalian patient, dissecting tissue obtained from said tissue resection or suction and dissociating said tissue into a cell suspension, removing adipocytes from the cell suspension, culturing the adipocyte-depleted cell suspension in EGM-2-MV media, and isolating adipose tissue-derived stromal cells secreting vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and granulocyte-colony stimulating factor (G-CSF). | 2014-10-23 |
20140315308 | GLUCOMANNAN SCAFFOLDING FOR THREE-DIMENSIONAL TISSUE CULTURE AND ENGINEERING - The present invention provides a neutralized glucomannan scaffold capable of promoting cell growth and suitable for three-dimensional tissue culture and engineering. The present invention also provides methods for making and degrading the neutralized glucomannan scaffold. The present invention further provides a method of growing cells on a neutralized glucomannan scaffold. | 2014-10-23 |
20140315309 | METHOD FOR MANUFACTURING IN VITRO VASCULARIZED TISSUE - The present invention relates to a method for manufacturing an in vitro vascularized tissue, which enables obtaining the in vitro vascularized tissue by inducing in vitro angiogenesis in a tissue using vascular cells, for use in in vitro research of diseases in vascularized tissues and developing a treatment. The method for manufacturing the in vitro vascularized tissue comprises the steps of: supplying to a container for manufacturing tissue a hydrogel in which vascularized tissue cells are mixed; submerging a collection tip to which vascular cells are coupled into the hydrogel; hardening the hydrogel while the collection tip is submerged; and supplying a cell culture fluid to the upper side of the hydrogel. | 2014-10-23 |
20140315310 | RECOMBINASE-BASED LOGIC AND MEMORY SYSTEMS - The invention provides, inter alia, recombinase-based systems that provide for integrated logic and memory in living cells. | 2014-10-23 |
20140315311 | Method and device for cell modification - The invention relates to a cell modification device, comprising a centrifugation chamber with at least one cell modifying surface with a normal vector having an angle of 135-45° to the rotational axis of the centrifugation chamber, wherein the centrifugation chamber comprises at least one input/output port and the cells to be modified are immobilized at the cell modifying surfaces by the rotation of the centrifugation chamber at 2 to 2000 g. Furthermore, the invention relates to a method for modifying cells comprising the steps—introducing cells in a cell modification device, comprising a centrifugation chamber with at least one cell modifying surface with a normal vector having an angle of 135-45° to the rotational axis of the centrifugation chamber wherein and comprising at least one input/output port, —immobilizing the cells on the cell modifying surfaces by the rotation of the centrifugation chamber at 2 to 2000 g—maintaining the rotation of the rotation of the centrifugation chamber until the cells are modified. | 2014-10-23 |
20140315312 | MODIFIED GENE SILENCING - This invention relates to methods of controlling gene expression or gene suppression in eukaryotic cells. One aspect of this invention includes modifying the degree of silencing of a target gene by use of a modified suppression element. Another aspect includes providing a eukaryotic cell having a desired phenotype resulting from transcription in the eukaryotic cell of a modified suppression element. Also provided are transgenic eukaryotic cells, transgenic plant cells, plants, and seeds containing modified suppression elements, and useful derivatives of such transgenic plant cells, plants, or seeds, such as food or feed products. | 2014-10-23 |
20140315313 | FILAMENTOUS FUNGI HAVING AN ALTERED VISCOSITY PHENOTYPE - Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications. | 2014-10-23 |
20140315314 | ENGINEERED LISTERIA AND METHODS OF USE THEREOF - The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes. | 2014-10-23 |
20140315315 | PROTEIN DETECTION - The present invention relates to reagents for separating proteins from detergent, reagents for detecting proteins in the presence of a detergent, and methods of using the same. The separating reagents contain a cyclic oligomer such as cyclodextrin and a cellulose derivative such as 2-hydroxyethyl cellulose. When used in combination with standard protein-complexing dyes, the reagents allow detection of proteins in electrophoresis gels at nanogram levels. | 2014-10-23 |
20140315316 | COLORIMETRIC RADIATION DOSIMETRY BASED ON FUNCTIONAL POLYMER AND NANOPARTICLE HYBRID - A method for colorimetric radiation dosimetry includes subjecting an aggregate including a polymeric matrix having uniformly dispersed nanoparticles therein to radiation. The aggregate is soaked in a solution selected to dissolve decomposed pieces of the polymeric matrix to release into the solution nanoparticles from the decomposed pieces. Color of the solution is compared to a reference to determine a dose of radiation based on number of liberated nanoparticles. | 2014-10-23 |
20140315317 | DISK-TYPE MICROFLUID SYSTEM AND METHOD FOR CHECKING BLOOD STATUS - A method for checking blood status comprises: a step of supplying blood to the centrifuge container of a disk; a step of rotating the disk to centrifuge the blood into blood cells and blood plasma in the centrifuge container, and detecting the actual moving distance per hour of the blood cells in the centrifuge container; and a step of establishing a first graph which represents the actual moving distance of the blood cells per hour, and a second graph which represents the theoretical moving distance of the blood cells per hour, and thereafter calculating the hematocrit of the blood cells and the viscosity of the blood plasma by comparing the first graph with the second graph. | 2014-10-23 |
20140315318 | ANALYTICAL METHODS FOR ANALYZING AND DETERMINING IMPURITIES IN DIANHYDROGALACTITOL - An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC with evaporative light scattering detection (ELSD); the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol. | 2014-10-23 |
20140315319 | BIOMOLECULE INTERACTION USING ATOMIC FORCE MICROSCOPE - The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the dendron are bound to the surface, and a terminus of the linear region of the dendron is functionalized. | 2014-10-23 |
20140315320 | CONTROL OVER HYDROGEN FLUORIDE LEVELS IN OXIDE ETCHANT - The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe. | 2014-10-23 |
20140315321 | Chloride Ion Fluorescence Detection Method and Device, and Use Thereof - A chloride ion fluorescence detection method and device, and a use thereof. The chloride ion fluorescence detection method utilizes chloride ions to influence luminescence characteristics of some photoluminescent substances to change the emission spectrum of the photoluminescent substances. The concentration of the chloride ions is detected through two processes comprising the fiber surface film forming and test liquid preparation of a fluorescent reagent sensitive to the chloride ions and measurement of information of fluorescence peak wavelengths or intensities. The method can be applied to the online assessment of the corrosion environment of steel bar concrete or the measurement of chloride ions in a laboratory. | 2014-10-23 |
20140315322 | METHOD FOR MEASURING ACETIC ACID CONCENTRATION IN BLOOD PLASMA - The present invention relates to providing a simple and highly reproducible method for measuring the concentration of acetic acid in blood plasma by using a gas chromatography/mass spectrometry (GC/MS), and more specifically relates to a method for measuring the concentration of acetic acid in blood plasma by using a gas chromatography/mass spectrometry (GC/MS), which comprises extracting acetic acid in blood plasma with methyl-tert-butyl ether (MTBE). | 2014-10-23 |
20140315323 | USE OF TRANSITION-METAL OXIDE NANOPARTICLES AS SENSITIVE MATERIALS IN CHEMICAL SENSORS FOR DETECTING OR ASSAYING VAPORS OF TARGET MOLECULES - The invention relates to the use of nanoparticles of at least one oxide of at least one transition metal doped with a rare earth element, particularly Y | 2014-10-23 |
20140315324 | DEVICE, METHOD AND APPARATUS FOR THE TRANSFER OF ANALYTES - According to the present invention, there is provided a device for transferring an analyte from a reaction chamber to a detector, which detector is capable of detecting said analyte. The device comprises a tubular member having a first end adapted to receive a sample containing said analyte within said reaction chamber and a second end adapted to communicate with a sample inlet of said detector; and a jacket for regulating the temperature of sample passing through the tubular member, wherein said jacket is disposed about at least a portion of the tubular member. Methods of using the device, and apparatus comprising the device, are also provided. The device may be used to transfer an analyte from a reaction chamber to a detector during the course of a chemical reaction, such that the reaction can be monitored in situ. | 2014-10-23 |
20140315325 | ASSEMBLY COMPRISING A REACTION VESSEL AND A SAMPLE MATRIX, SAMPLE MATRIX COMPRISING AN UPPER ADSORBENT LAYER AND A LOWER LATERAL FLOW LAYER - An assembly and related methods are described for the preparation and processing of samples in molecular biology assays and nucleic acid amplification reactions. The assembly allows rapid and easy processing with reduced sample handling compared to known sample preparation apparatus and methods. The assembly comprises a reaction vessel, a sample matrix and a lid. The invention further provides an integrated punch to punch out discs of the sample matrix into the reaction vessel (without handling); thereby reducing the sample handling required to generate the final amplified nucleic acid product. | 2014-10-23 |
20140315326 | Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes - A method is taught for the accurate determination of the premature rupture of membranes (PROM), defined as spontaneous rupture of membranes before the onset of uterine contractions. More specifically, a lateral flow assay strip tests for at least two antigens to greatly limit or eliminate the possibility of false negatives. A built in timer in the cassette holding the lateral flow assay further increases the accuracy of the test. A collection buffer vial with self-contained shipping and dropper caps and built in stand is also taught. | 2014-10-23 |
20140315327 | Methods for Measuring Concentrations of Biomolecules - The present invention provides methods for measuring the absolute concentration of a biomolecule of interest in a subject. Such biomolecules may be implicated in one or more neurological and neurodegenerative diseases or disorders. Also provided is a method for determining whether a therapeutic agent affects the in vivo metabolism of a central nervous system derived biomolecule. Also provided are kits for performing the methods of the invention. | 2014-10-23 |
20140315328 | SYSTEM AND METHOD FOR THE DETECTION OF ANALYTES BY CONTROLLED AGGREGATION NANOPARTICLES - A method for detecting an analyte in a sample, the method comprising contacting the analyte in a sample with nanoparticles comprising a capture probe for capturing said analyte, the capture probe being configured to act as a centre for controlled aggregation of nanoparticles with said analyte to form an aggregate of predefined form, detecting the analyte by detecting the shape and/or size of the aggregate is provided. Also provided are nanoparticles comprising a capture probe for capturing an analyte, wherein the capture probe is configured to act as a centre for controlled aggregation of nanoparticles with the analyte to form an aggregate of particular detectable size and/or shape, and an assay. | 2014-10-23 |
20140315329 | METHOD OF MANUFACTURING A MAGNETORESISTIVE-BASED DEVICE - A method of manufacturing a magnetoresistive-based device having magnetic material layers formed between a first electrically conductive layer and a second electrically conductive layer, the magnetic materials layers including a tunnel barrier layer formed between a first magnetic materials layer and a second magnetic materials layer, including removing the first electrically conductive layer and the first magnetic materials layer unprotected by a first hard mask, to form a first electrode and a first magnetic materials, respectively; and removing the tunnel barrier layer, second magnetic materials layer, and second electrically conductive layer unprotected by the second hard mask to form a tunnel barrier, second magnetic materials, and a second electrode. | 2014-10-23 |
20140315330 | MEASUREMENT DEVICE, MEASUREMENT METHOD, AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - There is provided a measuring apparatus including: an illuminator configured to illuminate, with an illumination light, a substrate having a pattern formed by exposure on a surface; a detector configured to detect the illumination light modulated by the pattern to output a detection signal; and a measuring unit configured to measure an exposure condition of the pattern of a desired portion by using the detection signals detected at a plurality of portions of the pattern. | 2014-10-23 |
20140315331 | Screening of Surface Passivation Processes for Germanium Channels - Candidate wet processes for native oxide removal from, and passivation of, germanium surfaces can be screened by high-productivity combinatorial variation of different process parameters on different site-isolated regions of a single substrate. Variable process parameters include the choice of hydrohalic acid used to remove the native oxide, the concentration of the acid in the solution, the exposure time, and the use of an optional sulfur passivation step. Measurements to compare the results of the process variations include attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), contact angle, atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray fluorescence (XRF). A sample screening experiment indicated somewhat less native oxide regrowth using HCl or HBr without sulfur passivation, compared to using HF with sulfur passivation. | 2014-10-23 |
20140315332 | System and Method for Increasing Productivity of Combinatorial Screening - The present invention provides systems and methods for simultaneous, parallel and/or rapid serial testing of material parameters or other parameters of the result of a process. The testing is typically used for screening different methods or materials to select those methods or materials with desired properties. A reactor structure used to form the materials may consist of an array of small isolated reaction chambers that overlie the substrate so that the substrate forms a bottom surface of each isolated reaction chamber. Test structures are formed on the substrate, where the location of each test structure corresponds to an isolated reaction chamber area of the reaction structure. Test structures are used to measure certain parameters, such as by probing contact pads for each test structure, or such testing may be performed in-situ during processing. | 2014-10-23 |
20140315333 | Apparatus and Method for Monitoring a Thickness of a Silicon Wafer with a Highly Doped Layer - Apparatus for monitoring a thickness of a silicon wafer with a highly-doped layer at least at a backside of the silicon wafer is provided. The apparatus has a source configured to emit coherent light of multiple wavelengths. Moreover, the apparatus comprises a measuring head configured to be contactlessly positioned adjacent the silicon wafer and configured to illuminate at least a portion of the silicon wafer with the coherent light and to receive at least a portion of radiation reflected by the silicon wafer. Additionally, the apparatus comprises a spectrometer, a beam splitter and an evaluation device. The evaluation device is configured to determine a thickness of the silicon wafer by analyzing the radiation reflected by the silicon wafer by an optical coherence tomography process. The coherent light is emitted multiple wavelengths in a bandwidth b around a central wavelength w | 2014-10-23 |
20140315334 | INTEGRATED CIRCUIT PACKAGE INCLUDING EMBEDDED THIN-FILM BATTERY - An integrated circuit package is provided with a thin-film battery electrically connected to and encapsulated with an integrated circuit die. The battery can be fabricated on a dedicated substrate, on the die pad, or on the integrated circuit die itself. | 2014-10-23 |
20140315335 | METHOD OF PROCESSING SUBSTRATE - A method of processing a substrate includes forming holes in bottom portions of a plurality of recesses formed in a substrate to be arranged in an array direction at a predetermined pitch by performing reactive ion etching on the bottom portions of the plurality of recesses. The forming holes in the bottom portions of the plurality of recesses is a process of preparing a substrate in which a dummy recess serving as a dummy is formed on at least one side of the array direction, in which the plurality of recesses that include the bottom portions in which the holes are formed are arranged, such that a recess is formed on both sides of a recess so that the plurality of recesses are formed at the predetermined pitch in the array direction and performing reactive ion etching on the bottom portions of the plurality of recesses of the prepared substrate. | 2014-10-23 |
20140315336 | APPARATUS FOR FORMING ORGANIC LIGHT EMITTING LAYER AND METHOD OF FORMING ORGANIC LIGHT EMITTING LAYER USING THE SAME - An organic light-emitting layer forming apparatus includes a stage supporting an intermediate product of an organic light emitting device, which includes a substrate, and a pixel defining layer including first openings. The apparatus includes a first mask disposed over the stage and including second openings, and a second mask disposed over the first mask and including third openings. The second mask is movable relative to the first mask between first and second positions. The third openings do not overlap the second openings in the first position while overlapping the second openings in the second position. T he apparatus includes an inkjet head unit disposed over the second mask and supplying an organic material to the third openings of the second mask in the first position. The second mask moves to the second position to transfer the organic material through the second openings. | 2014-10-23 |
20140315337 | SEMICONDUCTOR DEVICE AND METHOD FOR MANUFACTURING THE SAME - According to one embodiment, a semiconductor device includes first, second, and third molded bodies. The first molded body covers a first light emitting element, a part of a lead electrically connected to the first light emitting element, a first light receiving element configured to detect a light emitted from the first light emitting element, and a part of a lead electrically connected to the first light receiving element with a first resin. The second molded body covers a second light emitting element, a part of a lead electrically connected to the second light emitting element, a second light receiving element configured to detect a light emitted from the second light emitting element, and a part of a lead electrically connected to the second light receiving element with the first resin. The third molded body molds the first and the second molded bodies as one body using a second resin. | 2014-10-23 |
20140315338 | LIGHT-EMITTING DEVICE AND METHOD FOR MANUFACTURING SAME - Disclosed is a light-emitting device comprising a light-emitting element ( | 2014-10-23 |
20140315339 | METHOD OF MANUFACTURING ORGANIC LIGHT EMITTING DISPLAY - A manufacturing method of an organic light emitting display includes preparing a substrate including a cathode line, forming an anode electrode on the substrate, the anode electrode being insulated from the cathode line, forming an insulating layer having a first opening exposing a portion of the cathode line and a second opening exposing a portion of the anode electrode on the substrate, forming an organic layer on the insulating layer, forming an electrical connection portion electrically connected to the cathode line by supplying a conductive solution that dissolves the organic layer in an area of the organic layer corresponding to the first opening, and forming a cathode electrode overlapping with the electrical connection portion. | 2014-10-23 |
20140315340 | LASER DIODES WITH SCRIBE STRUCTURES - A method and device for emitting electromagnetic radiation using semipolar or nonpolar gallium containing substrates is described where the backside of the substrate includes multiple scribes that reduce stray light leaking. | 2014-10-23 |
20140315341 | METHOD OF FORMING ORGANIC LAYER AND METHOD OF MANUFACTURING ORGANIC LIGHT EMITTING DEVICE HAVING THE SAME - A method of forming an organic layer includes supplying a liquefied organic material, drying the liquefied organic material, supplying a solvent to an intermediate organic layer to swell the intermediate organic layer, and drying the swelled organic layer. The organic layer is formed to have a uniform thickness when the organic layer is formed by a solution-based printing method. | 2014-10-23 |
20140315342 | DEPOSITION APPARATUS, DEPOSITION METHOD, ORGANIC EL DISPLAY, AND LIGHTING DEVICE - A deposition method includes moving a substrate in a first direction within a processing chamber; generating a first source gas by evaporating a first film forming source material; discharging the first source gas from a first discharge opening toward the substrate being moved in the processing chamber; forming a first line-shaped thin film elongated in the first direction by depositing the first source gas on the substrate; generating a second source gas by evaporating a second film forming source material; discharging the second source gas from a second discharge opening offset from the first discharge opening in a second direction, which intersects the first direction, toward the substrate being moved in the processing chamber; and forming a second line-shaped thin film elongated in the first direction by depositing the second source gas on the substrate at a position spaced apart from the first line-shaped thin film. | 2014-10-23 |
20140315343 | APPARATUS FOR DEPOSITING ORGANIC FILM ON SUBSTRATE - A thin film deposition apparatus includes: a process chamber; and a substrate support comprising a substantially flat surface configured to support a substrate in the process chamber; and a deposition source configured to supply an organic material for deposition onto the substrate. The apparatus further includes a deposition mask assembly comprising first and second rollers disposed apart from each other in the process chamber; a thin film mask roll having a first end wound about the first roller and a second end wound about the second roller, wherein a deposition mask is defined on a first plane with a portion of the thin film mask roll extending between the first and second rollers; and a substrate transporting mechanism configured to transfer the substrate support on a second plane substantially parallel to the first plane within the process chamber. | 2014-10-23 |
20140315344 | DEPOSITION APPARATUS, ORGANIC LIGHT EMITTING DISPLAY APPARATUS, AND METHOD OF MANUFACTURING ORGANIC LIGHT EMITTING DISPLAY APPARATUS USING THE DEPOSITION APPARATUS - A deposition apparatus includes a deposition unit including a plurality of deposition assemblies, which are separated from a substrate at a predetermined distance and deposit a material onto the substrate while a first transfer unit transfers the substrate. Each of the plurality of deposition assemblies includes a patterning slit sheet facing a deposition source nozzle unit, a positional information obtaining unit obtaining positional information regarding a position of the substrate transferred by the first transfer unit, and a sheet stage adjusting a position of the patterning slit sheet with respect to the substrate transferred by the first transfer unit according to the positional information. | 2014-10-23 |
20140315345 | Methods For Thick Films Thermoelectric Device Fabrication - Solid state thermoelectric energy conversion devices can provide electrical energy from heat flow, creating energy, or inversely, provide cooling through applying energy. Thick film methods are applied to fabricate thermoelectric device structures using microstructures formed through deposition and subsequent thermal processing conditions. An advantageous coincidence of material properties makes possible a wide variety of unique microstructures that are easily applied for the fabrication of device structures in general. As an example, a direct bond process is applied to fabricate thermoelectric semiconductor thick films on substrates by printing and subsequent thermal processing to form unique microstructures which can be densified. Bismuth and antimony are directly bonded to flexible nickel substrates. | 2014-10-23 |
20140315346 | INTERFACE BETWEEN A I/III/VI2 LAYER AND A BACK CONTACT LAYER IN A PHOTOVOLTAIC CELL - The invention relates to a method of manufacturing a I-III-VI | 2014-10-23 |
20140315347 | Scalable Multi-Role Surface-Wave Plasma Generator - Systems and methods are described herein for generating surface-wave plasmas capable of simultaneously achieving high density with low temperature and planar scalability. A key feature of the invention is reduced damage to objects in contact with the plasma due to the lack of an RF bias; allowing for damage free processing. The preferred embodiment is an all-in-one processing reactor suitable for photovoltaic cell manufacturing, performing saw-damage removal, oxide stripping, deposition, doping and formation of heterostructures. The invention is scalable for atomic-layer deposition, etching, and other surface interaction processes. | 2014-10-23 |
20140315348 | THIN FILM SOLAR CELL - A thin-film solar cell which uses an InS-based buffer layer is produced by forming a metal back electrode layer on a substrate, forming a p-type light absorption layer on the metal back electrode layer, oxidizing the p-type light absorption layer surface, forming an InS-based buffer layer as an n-type high resistance buffer layer on the oxidized p-type light absorption layer, and forming an n-type transparent conductive film on the InS-based buffer layer. | 2014-10-23 |
20140315349 | SEMICONDUCTOR DEVICE AND METHOD FOR MANUFACTURING THE SAME - A semiconductor device in which fluctuation in electric characteristics due to miniaturization is less likely to be caused is provided. The semiconductor device includes an oxide semiconductor film including a first region, a pair of second regions in contact with side surfaces of the first region, and a pair of third regions in contact with side surfaces of the pair of second regions; a gate insulating film provided over the oxide semiconductor film; and a first electrode that is over the gate insulating film and overlaps with the first region. The first region is a CAAC oxide semiconductor region. The pair of second regions and the pair of third regions are each an amorphous oxide semiconductor region containing a dopant. The dopant concentration of the pair of third regions is higher than the dopant concentration of the pair of second regions. | 2014-10-23 |
20140315350 | WAFER PROCESS FOR MOLDED CHIP SCALE PACKAGE (MCSP) WITH THICK BACKSIDE METALLIZATION - A wafer process for MCSP comprises: depositing a metal bump on bonding pads of chips; forming a first packaging layer at front surface of wafer covering metal bumps while forming an un-covered ring at the edge of wafer to expose the ends of each scribe line located between two adjacent chips; thinning first packaging layer to expose metal bumps; grinding back surface of wafer to form a recessed space and a support ring at the edge of the wafer; depositing a metal seed layer and a thick metal layer at bottom surface of wafer in recessed space in a sequence; cutting off the edge portion of wafer; and separating individual chips from wafer by cutting through first packaging layer, the wafer and the metal seed and metal layers along the scribe line. | 2014-10-23 |
20140315351 | FABRICATION METHOD OF SEMICONDUCTOR PACKAGE WITHOUT CHIP CARRIER - A semiconductor package without a chip carrier formed thereon and a fabrication method thereof. A metallic carrier is half-etched to form a plurality of grooves and metal studs corresponding to the grooves. The grooves are filled with a first encapsulant and a plurality of bonding pads are formed on the metal studs. The first encapsulant is bonded with the metal studs directly. Each of the bonding pads and one of the metal studs corresponding to the bonding pad form a T-shaped structure. Therefore, bonding force between the metal studs and the first encapsulant is enhanced such that delamination is avoided. Die mounting, wire-bonding and molding processes are performed subsequently. Since the half-etched grooves are filled with the first encapsulant, the drawback of having pliable metallic carrier that makes transportation difficult to carry out as encountered in prior techniques is overcome, and the manufacturing cost is educed by not requiring the use of costly metals as an etching resist layer. | 2014-10-23 |
20140315352 | SEMICONDUCTOR DEVICE FABRICATING METHOD - A semiconductor device fabricating method includes forming device chip regions and a monitor chip region for processing management, on a substrate surface layer on one main surface side of a semiconductor substrate wafer, each device chip region having an active region and an edge region; after forming metal films on front surface of the device chip regions and the monitor chip region by vapor deposition and photolithography, forming protective films on the front surfaces of the device chip regions and monitor chip region; and grinding and polishing another main surface side of the semiconductor substrate wafer to thin the semiconductor substrate wafer. A difference between an area of one chip occupied by the protective film of the monitor chip region and an area of one chip occupied by the protective film of the device chip region is 20% or less. | 2014-10-23 |
20140315353 | FABRICATION METHOD OF PACKAGING SUBSTRATE, AND FABRICATION METHOD OF SEMICONDUCTOR PACKAGE - A fabrication method of a packaging substrate includes: providing a metal board having a first surface and a second surface opposite to the first surface, wherein the first surface has a plurality of first openings for defining a first core circuit layer therebetween, the second surface has a plurality of second openings for defining a second core circuit layer therebetween, each of the first and second openings has a wide outer portion and a narrow inner portion, and the inner portion of each of the second openings is in communication with the inner portion of a corresponding one of the first openings; a first encapsulant in the first openings; a second encapsulant in the second openings; and forming a surface circuit layer on the first encapsulant and the first core circuit layer. | 2014-10-23 |