42nd week of 2013 patent applcation highlights part 45 |
Patent application number | Title | Published |
20130273479 | PROCESSESS AND COMPOSITIONS FOR REMOVING SUBSTANCES FROM SUBSTRATES - Processes associated apparatus and compositions useful for removing organic substances from substrates, for example, electronic device substrates such as microelectronic wafers or flat panel displays, are provided. Processes are presented that apply a minimum volume of a composition as a coating to the inorganic substrate whereby sufficient heat is added and the organic substances are completely removed by rinsing. The compositions and processes may be suitable for removing and, in some instances, completely dissolving photoresists of the positive and negative varieties as well as thermoset polymers from electronic devices. | 2013-10-17 |
20130273480 | START-UP TORCH - An apparatus includes a tuyere, a plasma torch positioned to inject hot gas into the tuyere, and a plurality of nozzles configured to inject a combustible material into the tuyere for combustion of the combustible material within the tuyere. The apparatus can be used to practice a method including: injecting a combustible material into a plurality of tuyeres in a wall of a reactor vessel, using a plasma torch to inject hot gas into the tuyeres to ignite the combustible material, and directing heat from combustion of the combustible material into the reactor vessel to preheat the reactor vessel. | 2013-10-17 |
20130273481 | BOILER AND OPERATING METHOD OF SAME - A boiler operating method operates a boiler by switching between air combustion mode and oxygen combustion mode when burning fossil fuel with first combustion gas and second combustion gas. The second combustion gas compensates for oxygen deficiency in the first combustion gas. The air combustion mode uses air as the first combustion gas and the second combustion gas while the oxygen combustion mode uses mixed gas of combustion flue gas and oxygen-rich gas as the first combustion gas and the second combustion gas, the combustion flue gas being produced when the fossil fuel is burned. By mixing the oxygen-rich gas in the air in the process of switching between air combustion mode and oxygen combustion mode, the air being the first combustion gas used in the air combustion mode, the boiler operating method can switch between the air combustion mode and oxygen combustion mode while maintaining stable combustion. | 2013-10-17 |
20130273482 | Dual Fuel Heater - A heater having first and second oxygen depletion sensors and a main burner injector and configurable for the delivery of at least first and second types of fuels. | 2013-10-17 |
20130273483 | FLAME SENSOR - A flame sensor apparatus is provided including a sensor for sensing specific characteristics of a flame within a combustion chamber. The sensor includes a silicon carbide photodiode, and the sensor is spaced a distance from the combustion chamber. In addition, a fiber optic cable assembly extends between the sensor and the combustion chamber. The fiber optic cable can convey the specific characteristics of the flame from the combustion chamber to the sensor. The fiber optic cable assembly is included as part of a sealed array filled with an inert gas. In addition, a method of sensing specific characteristics of a flame is also provided. | 2013-10-17 |
20130273484 | Valve Assembly For A Lighter And Gas Lighter Comprising Such Valve Assembly - The valve assembly includes a tubular rigid body that can be arranged in the upper wall of a lighter gas reservoir and a hollow rod extending along a central axis from a lower end located within the tubular body to an upper end located outside the tubular body. A retaining member (R), on which the upper end of the tubular body is crimped, surrounds a cylindrical portion of the hollow rod. Movement of the hollow rod through the retaining member from a closed position to an opened position enables gas to flow from a lower hole of the valve assembly to the upper end of the hollow rod. The retaining member (R) made of synthetic resin has an annular shape with a slit that can be circumferentially expanded. This member has a reduced thickness at a contact area with crimped portion of the tubular body. | 2013-10-17 |
20130273485 | GAS FIRED RADIATION EMITTER WITH EMBOSSED SCREEN - The present invention relates to a gas fired infrared radiation emitter comprising a burner plate ( | 2013-10-17 |
20130273486 | LAYER FURNACE SYSTEM AND METHOD FOR OPERATING THE LAYER FURNACE SYSTEM - A layer furnace system for thermal treatment of metal components includes multiple heating levels which arranged on top of each other in vertical direction, and at least one heat source, wherein flat metal components, in particular metal sheets can be inserted into the heat levels and at last one heating level can be closed by a furnace door, wherein the furnace door is can be displaced in vertical direction for opening and closing the heat level located there behind. The present invention also relates to a method for operating the layer furnace system. | 2013-10-17 |
20130273487 | SAMPLE HEATING METHOD AND HEATING CONTROL DEVICE - In a sample heating method which uses a microchip, using the microchip which includes a vessel portion ( | 2013-10-17 |
20130273488 | REDUCED REGISTRATION BONDING TEMPLATE - A dental template for positioning an object on teeth of a patient and method for fabricating the same. The method includes creating a digital model of the patient's teeth, creating a simplified template model based on the digital model, and fabricating the dental template based on the simplified template model. The template model is simplified by removing certain features of the patient's tooth anatomy. The dental template can be located on a patient's teeth using four or fewer positioning teeth. | 2013-10-17 |
20130273489 | Adapter Device for Extension of Mini-Plates, Pliers for the Attachment Thereof and Method for Extension and Attachment of Mini-Plates - An adapter device for extension of miniplates used in orthodontic treatments, which provides for the extension of the plate for the most anterior or posterior and superior or inferior positions, and also the fixation of orthodontic accessories, which can be used for various skeletal anchorage systems available on the market, pliers for the attachment of the device, and a method for extension and attachment of miniplates by use of the adapter devices of the present invention. | 2013-10-17 |
20130273490 | METHOD AND DEVICE FOR INCREASING BONE DENSITY IN THE MOUTH - A dental device includes a mouthpiece configured to sit against occlusal surfaces of a patient's teeth and a motor connected to the mouthpiece. The motor is configured to vibrate the mouthpiece at a frequency between 60 and 120 Hz and an acceleration between 0.03 G and 0.06 G such that the mouthpiece places an axial vibratory force on the occlusal surfaces. | 2013-10-17 |
20130273491 | SYSTEM AND METHOD FOR EVALUATING ORTHODONTIC TREATMENT - A system and method for evaluating dental treatment utilizes virtual models created from scanned plaster casts. Patient's teeth are directly scanned with a three dimensional scanner or plaster casts of the patient teeth following treatment are scanned for evaluation. A planned configuration based on a plaster cast prior to treatment is created and the desired position and the two models are compared so that the actual position of the teeth may be compared to the desired position after treatment. Superimposition of the virtual models provides accurate and precise measurement of variances between the two virtual models. Difficulties due to superimposing the models, which are of the entire arch and evaluations based on individual teeth are overcome by applying an iterative closest point algorithm to correct the position and provide a truer measurement for evaluation. Differences between a preferred position of a patient's teeth and actual position of a patient's teeth may be assigned a score and the score may be compared to other patients to rank the patient needs. | 2013-10-17 |
20130273492 | System and Method for Improved Intra-Oral Scanning Protocol and Calibration - A method of providing an accurate three-dimensional scan of a dental arch area is disclosed. The arch area has two segments and a connecting area between the two segments. The connecting area has homogeneous features. A connecting-geometry tool with at least one definable feature is affixed to the arch area. The definable feature overlays at least part of the connecting area. The arch area is scanned to produce a scanned dataset of the arch area. The definable feature of the connecting-geometry tool on the connection area is determined based on the scanned dataset. The dimensions of the arch area are determined based on the data relating to the definable features from the scanned dataset. | 2013-10-17 |
20130273493 | SPECTRAL SCANNING PHOTOCROSSLINKING DEVICE - A photo-curing device includes a light source for initiating the curing of a photo-curable material. The light source has light-emitting diodes, each emitting light in a determined wavelength range, the wavelength ranges of the LEDs overlapping partially so as to cover a continuous wavelength range that is broader than the wavelength range of each LED. An activation device is provided for selectively activating each LED. | 2013-10-17 |
20130273494 | Fluid Controller - A fluid conditioning system is adapted to condition the fluid used in medical and dental cutting, irrigating, evacuating, cleaning, and drilling operations. The fluid may be conditioned by adding flavors, antiseptics and/or tooth whitening agents such as peroxide, medications, and pigments. In addition to the direct benefits obtained from introduction of these agents, the laser cutting properties may be varied from the selective introduction of the various agents. | 2013-10-17 |
20130273495 | PRELOADED DENTAL CAP AND RETRACTION MATERIAL FOR GINGIVAL TISSUE RETRACTION - A method and a device for effecting the cordless retraction of the gingival sulcus tissue that includes a cap or dam to be fitted onto a tooth. The well of the cap is pre-filled with a predetermined amount of a flowable non-setting kaolin based retraction material having a heavy viscosity or putty consistency. The preloaded cap is fitted to a prepared tooth so that when pressure is applied onto the cap, the retraction material is displaced under pressure and forced to flow into the sulcus, causing the gingival tissue to retract away from the tooth to enlarge the gingival sulcus. An internal ridge aids in retaining the retraction material within the cap. | 2013-10-17 |
20130273496 | POWERED TOOTHBRUSH WITH ASSOCIATED ORAL SOLUTION DISPENSER MECHANISM - An oral solution dispenser apparatus for attachment to a powered toothbrush handle having a drive coupling mounted thereon, includes a housing adapted for attachment to the handle, the housing having a recess therein for receiving a cartridge containing the oral solution, a pump disposed in the housing for moving the oral solution from the cartridge, and an outlet nozzle extending from the housing and adapted to permit movement of the oral solution from the pump and from the housing. A head having bristles thereon is adapted to interconnect with the handle drive coupling and the housing outlet nozzle, to facilitate powered movement of the bristles and movement of the oral solution from the outlet nozzle to proximate the bristles. | 2013-10-17 |
20130273497 | Swaggering Endodontic Instruments - Endodontic instruments are described which have at least a section with a center of mass offset from an axis of rotation so that when the instrument is rotated, the section bends away from the axis of rotation. | 2013-10-17 |
20130273498 | DENTAL IMPLANT - A dental implant comprising an implant body which has an asymmetric root portion receivable in an asymmetric open root cavity of the patient and engagement means on the asymmetric root portion to at least in part engage a surface of the root cavity so as to prevent or inhibit unintentional extraction. The asymmetric root portion is complementarily shaped to fit the said asymmetric open root cavity, thus substantially dispensing with the need for protracted preparation of the root cavity and providing substantially immediate stability for the prosthetic tooth. | 2013-10-17 |
20130273499 | SET OF FIXTURES, AN IMPLANTATION SYSTEM AND A METHOD OF SELECTING A FIXTURE FROM A SET OF FIXTURES - The present invention relates to a set of fixtures for installation in bone tissue. Each fixture provides a static strain to the bone which is different from the static strain provided by the other fixtures of the set. The difference in static strain may be at least with respect to magnitude and/or axial extension. The invention also relates to an implantation system and a method of selecting a fixture from a set of fixtures. | 2013-10-17 |
20130273500 | Dental Implant and Method for Rapid Integration - The invention relates to methods of stabilizing bone implants, comprising inserting a self tapping implant having at least two helical grooves running in opposite directions around the implant wherein the implant generates a minimum of bone debris during insertion and implant is integrated within 3-6 weeks. | 2013-10-17 |
20130273501 | METHOD OF MAKING DENTAL PROSTHESIS AND DUCTILE ALLOYS FOR USE THEREIN - A dental prosthesis comprising a metal alloy pre-form and a dental porcelain veneer coating the metal alloy, wherein the metal alloy has a composition comprising, in % by weight, about 30-40% Co, 25-40% Ru, 20-40% Cr, and 0-0.1% Ni and wherein a coefficient of thermal expansion of the metal alloy is compatible with that of the dental porcelain to prevent cracking of the porcelain | 2013-10-17 |
20130273502 | DENTAL PROBE, A METHOD OF FORMING THE PROBE AND A METHOD OF USING THE PROBE - A dental probe is disclosed which is designed to be used to probe around and between teeth and surrounding soft tissue in a person's mouth. The dental probe has an arcuately shaped first portion terminating in a blunt tip and a second portion secured to the first portion opposite the tip. The dental probe also has a textured outer surface. The dental probe is capable of transferring a solution or liquid medication onto the teeth and surrounding soft tissue in a person's mouth. A method of molding the dental probe and a method of using the dental probe are also disclosed. | 2013-10-17 |
20130273503 | TACTICAL TRAINING AIDS - Contact-indicating devices including an elongate contacting member, and a housing configured to enclose a portion of the contacting member, the housing further enclosing a translation sensor configured to detect an inward longitudinal translation of the contacting member, and a rotation sensor configured to detect a pivoting of the contacting member in a first direction. The disclosed devices further include at least one indicating element, where the indicating element is configured to differentiate between the detected longitudinal translation of the contacting member and the detected pivoting of the contacting member in the first direction. | 2013-10-17 |
20130273504 | Shooting Simulation System and Method Using An Optical Recognition System - A shooting simulation system and method. The system a firearm held by a user. In addition, the user has a user computer and an optical system associated with the firearm for capturing an image. The image provides information on a trajectory of a simulated bullet fired from a shooting firearm. The optical system is aligned relative to a known sight of the shooting firearm. The optical system captures the image when a trigger of the shooting firearm is pulled. The system also includes an image recognition system for determining if the captured image is a legitimate target. The user computer determines if the captured image is a hit or a miss of the target using only information obtained from the optical system and image recognition system for determining if the captured image is a hit or a miss of a target. | 2013-10-17 |
20130273505 | Computer Implemented Method for Facilitating Proscribed Business Operations - In a computer implemented method for facilitating proscribed business operations, software operable with a computer having a display associated therewith includes a training module and an instruction module, each accessible by a user. The training module includes at least one training session selectable by the user, and the instruction module includes at least one instruction set selectable by the user. Upon selection of one of the training sessions step-by-step training instructions are displayed for performing one or more tasks. The software is operable to record and store information relevant to the selected training sessions in a database. Upon selection of one of the instruction sets, the software is operable to display step-by-step instructions for performing one or more tasks. The software is remotely changeable and remotely updatable. | 2013-10-17 |
20130273506 | Automated Food Intake Data Acquisition And Monitoring System - A system and method for collecting food intake related information, processing the information into a caloric value, and recording and reporting the value is provided. The system includes an electronic device having a sensor, an input device, a display, processor, memory, and code modules executing in the processor for implementation of the method. Information concerning the swallowing of food is collected. Weighting factors related to the caloric concentration of the food being ingested are also collected. The caloric value of the users eating is computed by the processor by combining the swallow data with weighted parameters in accordance with an algorithm. The caloric value is recorded in a user's profile and notifications can be generated based on the caloric value and a historical record of food intake information can be maintained and provided to the user via a portal such as a smart phone device or the internet. | 2013-10-17 |
20130273507 | CONSUMER INFORMATION SYSTEM FOR NUTRITIONAL SUBSTANCES - Disclosed herein is a consumer communication system for nutritional substances. The consumer information system obtains information regarding the nutritional substance being consumed by the consumer, and provides that information to the other constituents in the nutritional substance supply system. | 2013-10-17 |
20130273508 | Food Content Detector - A system may include utensil means for portioning a foodstuff into a first portion and a second portion, a means for detecting a first portion size for the first portion with the utensil means, a means for detecting a second portion size for the second portion with the utensil means, and a means for determining a cumulative amount of portioned foodstuff based upon the first portion size and the second portion size. | 2013-10-17 |
20130273509 | Method of Monitoring Nutritional Intake by Image Processing - A method of monitoring nutritional intake by image processing is completed through a portable electronic computing device, where the computing device is communicably coupled with a database. At least one meal image is taken by the computing device, where the at least one meal image can be a three-dimensional image, a plurality of images, and a nutritional label image with at least one image. The at least one meal image enables the software to identify at least one component and a portion size of the at least one meal image. Then meal calories and nutritional facts are calculated and stored in order to monitor the intake food of an individual. | 2013-10-17 |
20130273510 | Handwriting method for teaching roman alphabet - A muscle movement handwriting teaching method for teaching handwriting using a novel lettering guide and an method of instruction which takes advantage of the similar hand movements used with-in particular groups of letters. The learning of these letters is organized so that after one letter is mastered, another letter is learned based on the similarities of hand movements used in printing a learned letter and the next letter being taught. The handwriting method facilitates learning how to read and write in new languages. | 2013-10-17 |
20130273511 | Method of Teaching Reading and Spelling With a Progressive Interlocking Correlative System - The invention teaches students all of the graphic representations of phonemes and orthography using a series of word charts (covering over 18,000 independent words) and integrated program materials. The graphic representations of phonemes are presented to a student according to the frequency of use in words and in the language, and the progressive dependence of one set of graphic representations of phonemes on another. The teaching methods of this invention provide a system for learning how to decode and encode as interchangeable skills. Thus, the student learns to reason out the sounds and spelling of thousands of words. Integrated program learning materials provide mnemonic devices to reinforce the learning in a systematic way. | 2013-10-17 |
20130273512 | Checkerboard Math/Dora's Grid Math - A mathematical teaching aid based on a grid system. There are multiple grid based modules meant to teach math concepts from preK thru college level math. There are modules for teaching how to count, addition, subtraction, multiplication, division, and fraction manipulation (addition, subtraction, multiplication, division, equivalencies and LCD.) The system provides a physical, and visual model of math and lends itself to self-discovery/self-assistance by the student. The system is attractive to the student because coloring by the student is a part of the learning process, so the student is having fun while learning. This system exceeds the criteria for an ideal math model. These criteria are discussed in the definitive article (Murata, Aki (2008) ‘Mathematics Teaching and Learning as a Mediating Process: The Case of Tape Diagrams’, Mathematical Thinking and Learning, 10:4, 374-406.) This system is easy to use, inexpensive, and puts the student on math learning auto-pilot. | 2013-10-17 |
20130273513 | MATH MANIPULATIVES FOR TEACHING ROUNDING - A math manipulative for assisting students with rounding skills includes a number line has ends attached to each of two slides. Windows on the ends of the number line highlight a starting number (on the left hand of the number line) and an ending number (on the right hand of the number line), where the starting and ending numbers straddle the number to be rounded. The math manipulative provides the student with a visual representation of the number to be rounded, allowing the student to choose the starting or ending number to perform the rounding task and solve the rounding problem. | 2013-10-17 |
20130273514 | Optimal Strategies in Security Games - Different solution methodologies for addressing problems or issues when directing security domain patrolling strategies according to attacker-defender Stackelberg security games. One type of solution provides for computing optimal strategy against quantal response in security games, and includes two algorithms, the G | 2013-10-17 |
20130273515 | SYSTEM, METHOD AND APPARATUS FOR GENERATION OF LESSONS - A system for creating a lesson by a client of training material includes a computer that is operatively interfaced to storage, in which, a plurality of frames are stored. Each of the frames has a component of training. Software running on the computer provides a lesson generation tool. The software provides for searching the plurality of frames to create a subset of the frames that correspond to a search criteria. The software further provides for selection, by the client, of a set of desired frames from the subset of the frames and the software creates a lesson that includes the desired frames. | 2013-10-17 |
20130273516 | Automatic Determination of User Alignments and Recommendations for Electronic Resources - Various implementations for automatically determining user alignments and recommendations for electronic resources are described. One example implementation includes an assessment module, an alignment module, and a recommender. The assessment module determines performance levels of two or more users of an educational platform. The alignment module determines an alignment between the two or more users of the educational platform based on the performance levels of the two or more users. The recommender generates a recommendation for a social graph connection between the two or more users in a social graph based on the alignment. | 2013-10-17 |
20130273517 | ON-LINE INTEGRATION AND CREDIT-GRANTING PLATFORM FOR LEARNERS SEEKING AND ENGAGING IN PRACTICE-BASED LEARNING IN THE REAL WORLD - An integration system is provided for finding, enabling, and documenting completion of practice-based, real world experiences. One kind of collaboration system is an educational platform for providing learner-centric, real-world learning experiences, and supervising, evaluating, and granting institution credit for such learning experiences. A registry allows real world subject matter experts to offer supervision of real-world learning experiences and for learners to search for practice-based learning opportunities and to contact the associated supervisor to establish a learning experience in conjunction with an institution offering credit. A collaboration platform may provide targeted communications among learner, supervisor, and institutional representative (e.g. teacher) for establishing requirements of completion, tracking progress, gathering evidence of completion, and evaluating the quality of the evidence per each identified learner. The system may also comprise an accreditation module for translating a point score into a grade and/or an amount of institutional credit to be awarded to the learner. | 2013-10-17 |
20130273518 | Portable Erasable Sign - A portable, erasable sign for use in sporting events and public gatherings. The sign is self-supporting, but flexible enough to be carried and stored in a compact manner. The portable, erasable sign may include openings to facilitate holding of the sign. In certain embodiments, the sign may be rolled up when it is not being displayed. A strap, for example a Velcro strap, or an elastic band may be used to secure the sign in the rolled up position. The surface of the sign is such that any message printed thereon can be erased and replaced with a new message. In particular embodiments, the portable, erasable sign may be imprinted with the insignia for an organization, or a professional or university sports franchise. | 2013-10-17 |
20130273519 | COMPOSITION FOR TREATING BLOOD AND SET OF DIAGNOSTIC KIT COMPRISING THE SAME TO DETECT AUTOIMMUNE DISEASE - The present invention relates to a composition for treating blood, a set of a diagnostic kit comprising the same to detect an autoimmune disease, and a method of monitoring an autoimmune disease using the same. | 2013-10-17 |
20130273520 | COMPOSITION, DEVICE, AND METHOD FOR BIOLOGICAL AIR SAMPLING - The present invention generally relates to air sampling of biological compounds. Specifically, the present invention relates to a device and method for sampling the ambient air for detecting microbial propagules, microbial propagules being any spore, vegetative cell, or virion of microbiological origin including all bacteria, fungi, viruses, protozoans, molds, slime molds, chlamydospores, hyphae, and cysts. | 2013-10-17 |
20130273521 | SIGNALLING SYSTEM - The invention concerns a system for detecting a target nucleic acid molecule of a particular sequence in a sample, said system comprising (i) an oligonucleotide primer complementary to a said target nucleic acid molecule, which primer has no internal complementarity, is able to amplify said target sequence and carries a first label linked to said oligonucleotide at its 5′ end; and (ii) an oligonucleotide probe which carries a second label that is able to interact with said first label to produce a detectable signal, wherein the oligonucleotide probe binds an extension product of said primer such that the first and second label can interact to produce a detectable signal. Methods for using said system in particular in a nucleic acid assay, kits comprising the system and elements of it form a further aspect of the invention. | 2013-10-17 |
20130273522 | NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES - This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease. | 2013-10-17 |
20130273523 | NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES - This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease. | 2013-10-17 |
20130273524 | DEVICE FOR PERFORMING A BLOOD, CELL, AND/OR PATHOGEN COUNT AND METHODS FOR USE THEREOF - Devices and methods for performing a point of care blood, cell, and/or pathogen count or a similar blood test. Disclosed herein are systems that can be used to provide rapid, accurate, affordable laboratory-quality testing at the point of care. The systems described herein are capable of imaging and counting individual cells in a prepared cell sample (e.g., a peripheral blood smear or a blood sample prepared in a microfluidic device) or another prepared cell-containing sample without the need for a microscope or other expensive and cumbersome optics. The systems described herein are designed to eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such systems may include automated data reporting and decision support. | 2013-10-17 |
20130273525 | MULTIPLEX METHOD FOR DETECTING AN INFECTION - The invention relates to a method for the in vitro diagnostic detection of an infection with a microorganism, comprising placing a biological sample, in a single assay receptacle, in the presence of particles, each carrying at least one specific detectable physical parameter, and belonging to at least two different groups, one of the groups carrying an anti-IgM capture antibody and the other group carrying a capture antigen derived from said microorganism. | 2013-10-17 |
20130273526 | DNA Polymerases Having Improved Labeled Nucleotide Incorporation Properties - The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label interaction regions are located at portions of the O-helix, the K-helix, and the inter O-P helical loop of Taq DNA polymerase or analogous positions in other DNA polymerases. | 2013-10-17 |
20130273527 | METHOD FOR INDUCING CELL SENESCENCE BY RECOMBINANT INTERFERON WITH ALTERED SPATIAL CONFIGURATION - This invention provides a method for inducing cell senescence by recombinant interferon with altered spatial configuration, wherein the interferon is encoded by a nucleotide sequence having the sequence of SEQ ID NO.2. | 2013-10-17 |
20130273528 | DEVICE FOR PERFORMING A DIAGNOSTIC TEST AND METHODS FOR USE THEREOF - Assay cassettes and testing devices that can be used to provide rapid, accurate, affordable, laboratory-quality testing at the point of care. Such assay cassettes and testing devices are designed to provide rapid, quantitative test results in a point-of-care setting or the like. Likewise, such assay cassettes and testing devices may eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such testing device may include automated data reporting and decision support. Methods for performing point of care diagnostic tests are also disclosed. | 2013-10-17 |
20130273529 | Identifying and Correcting An Allelic Ladder Signal For DNA Analysis - A method for determining an allelic ladder signal for DNA analysis includes obtaining a measured allelic ladder signal for an allelic ladder substance, which includes a plurality of fragments, obtaining a reference set of expected fragment sizes of fragments of the ladder substance, and generating a signal identifying whether a peak for a fragment size of the measured ladder signal is a true peak of the ladder substance based on the reference set of expected fragment sizes, wherein the allelic ladder signal for DNA analysis includes the true peaks identified in the signal. | 2013-10-17 |
20130273530 | ANALYTICAL DEVICE AND ANALYTICAL METHOD - The present invention provides a technique capable of simply analyzing a target to be analyzed. An analytical device of the present invention includes a basal plate; a nucleic acid element; and a detection section of detecting a signal. The nucleic acid element and the detection section are arranged on the basal plate. The nucleic acid element includes a first nucleic acid molecule and a second nucleic acid molecule. The first nucleic acid molecule is a nucleic acid molecule capable of binding to a target. The second nucleic acid molecule is a nucleic acid molecule capable of binding to streptavidin. When the target does not bind to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is inactivated. When the target binds to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is activated. The detection section detects binding between the second nucleic acid molecule and the streptavidin. The target is bound to the first nucleic acid molecule, so that the streptavidin is bound to the second nucleic acid molecule. Thus, the target can be analyzed through detecting the binding between the second nucleic acid molecule and the streptavidin using the detection device. | 2013-10-17 |
20130273531 | AMBIENT TEMPERATURE STABLE KITS FOR MOLECULAR DIAGNOSTICS - A method for processing DNA polymerase and/or dNTPs for use in an amplification procedure, includes providing a solution mixture, the solution mixture including a DNA polymerase and/or dNTPs, a buffer solution and at least one stabilizing agent and hydration reducing the solution mixture. The solution mixture is hydration reduced at a temperature between 0° C. and about 100° C. | 2013-10-17 |
20130273532 | UPREGULATION OF RACK-1 IN MELANOMA AND ITS USE AS A MARKER - The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocyte cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to a method for determining the tumoral status of a melanocyte cell of a mammal, comprising the detection of overexpression of RACK-1 protein in the melanocyte cell, and the deduction of the tumoral state of said cell from the overexpression of RACK-1 protein. | 2013-10-17 |
20130273533 | MOLECULAR FLUX RATES THROUGH CRITICAL PATHWAYS MEASURED BY STABLE ISOTOPE LABELING IN VIVO, AS BIOMARKERS OF DRUG ACTION AND DISEASE ACTIVITY - The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides the necessary information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through one or more metabolic pathways of interest. By this method, a comparison between subjects and control subjects reveals the effects of the chemical entity or entities on the biomarkers. This, in turn, allows for the identification of potential therapeutic uses or toxicities of the compound. Combinations of compounds can also be systematically evaluated for complementary, synergistic, or antagonistic actions on the metabolic pathways of interest, using the methods of the present invention as a strategy for identifying and confirming novel therapeutic or toxic combinations of compounds. | 2013-10-17 |
20130273534 | SOCS-3 PROMOTER METHYLATION IN CANCER - This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression. | 2013-10-17 |
20130273535 | NDM-1 POLYMERASE CHAIN REACTION (PCR) ASSAY - Provided herein are compositions, methods, and kits for detection, identification, and analysis of NDM-1 variant nucleic acid. In particular, provided herein are kits, compositions, and methods for the detection, identification, and analysis of the NDM-1 variant nucleic acid and bacteria o other organisms carrying the NDM-1 variant nucleic acid. | 2013-10-17 |
20130273536 | COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS - The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency. | 2013-10-17 |
20130273537 | Transcriptome In Vivo Analysis - The invention provides compositions and methods that permit a hybrid nucleic acid molecule to enter a cell and when specifically activated within the cell, the molecule anneals to endogenous cellular RNA and permits the isolation of the RNA. | 2013-10-17 |
20130273538 | METHOD FOR IDENTIFYING OLFACTORY RECEPTOR INCLUDED IN ONE OLFACTORY CELL - The present invention provides a novel method for identifying an olfactory receptor included in one olfactory cell. In the present invention, amplified is the cDNA derived from the mRNA of the one olfactory cell by a PCR method using a forward primer represented by SEQ ID: 01 and a reverse primer represented by SEQ ID: 02. Subsequently, determined is whether or not a gene sequence of the amplified cDNA corresponds with one gene sequence included in gene sequences coding for olfactory receptors included in the mouse olfactory receptor group A. Finally, determined is that the olfactory receptor included in the one olfactory cell is the olfactory receptor which corresponds to the one gene sequence which corresponds with the gene sequence of the cDNA in the previous step, if the gene sequence of the cDNA corresponds with the one gene sequence in the previous step. | 2013-10-17 |
20130273539 | METHOD FOR IDENTIFYING OLFACTORY RECEPTOR INCLUDED IN ONE OLFACTORY CELL - The present invention provides a novel method for identifying an olfactory receptor included in one olfactory cell. In the present invention, amplified is the cDNA derived from the mRNA of the one olfactory cell by a PCR method using a forward primer represented by SEQ ID: 01 and a reverse primer represented by SEQ ID: 02. Subsequently, determined is whether or not a gene sequence of the amplified cDNA corresponds with one gene sequence included in gene sequences coding for olfactory receptors included in the mouse olfactory receptor group A. Finally, determined is that the olfactory receptor included in the one olfactory cell is the olfactory receptor which corresponds to the one gene sequence which corresponds with the gene sequence of the cDNA in the previous step, if the gene sequence of the cDNA corresponds with the one gene sequence in the previous step. | 2013-10-17 |
20130273540 | METHOD FOR CHROMOGENIC DETECTION OF TWO OR MORE TARGET MOLECULES IN A SINGLE SAMPLE - The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule. | 2013-10-17 |
20130273541 | Breast Cancer Susceptibility Gene GT198 and Uses Thereof - It has been discovered that the human GT198 gene (gene symbol PSMC3IP) at chromosome 17q21 acts as a tumor suppressor. The mutation of the GT198 gene causes the increased dominant negative splice variant activity and leads to the loss of wild type GT198 function, and in turn, induces breast and ovarian cancers. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to the GT198 gene mutations. Another embodiment provides methods and compositions for detecting cancer due to the mutation of the GT198 gene. Still another embodiment provides methods for identifying compounds, antibodies and natural product molecules that are useful for treating cancer due to the mutations of the GT198 gene. Preferably the disclosed compositions antagonize or interfere with the biological activity of splice variants of GT198. | 2013-10-17 |
20130273542 | DETECTION OF GLEEVEC RESISTANCE - The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. | 2013-10-17 |
20130273543 | GENETIC VARIANTS USEFUL FOR RISK ASSESSMENT OF THYROID CANCER - The invention discloses genetic variants that have been determined to be susceptibility variants of thyroid cancer. Methods of disease management, including methods of determining susceptibility to thyroid cancer, methods of predicting response to therapy and methods of predicting prognosis of thyroid cancer using such variants are described. The invention further relates to kits useful in the methods of the invention. | 2013-10-17 |
20130273544 | METHODS AND COMPOSITIONS FOR EXOSOME ISOLATION - Disclosed are methods, compositions and kits for the isolation of exosomes from biological fluids and tissues. Volume-excluding polymers are used to precipitate exosomes from biological samples thereby allowing exosome isolation by low-speed (benchtop) centrifugation or filtration. Further fractionation of exosomes after precipitation is also described. | 2013-10-17 |
20130273545 | Abnormalities of Phosphatase 2A (PP2A) for Diagnosis and Treatment of Alzheimer's Disease - This invention relates to methods of diagnosing Alzheimer's disease and methods of screening for compounds for the treatment or prevention of Alzheimer's disease. The methods are based upon newly discovered differences in protein phosphatase 2A (PP2A) function and related molecular events in Alzheimer's disease cells compared to control cells. In one embodiment, differences in basal PP2A gene expression in Alzheimer's cells are compared to controls. In another embodiment differences in PP2A protein and enzyme activity are compared in test and control cells. In another embodiment differences in response to substances that inhibit PP2A function are compared. Still another embodiment detects differences in the subcellular distribution of phosphorylated Erk1/2, a substrate of PP2A, in normal and Alzheimer's disease cells. The detection of Alzheimer's disease-specific differences in PP2A function and related events in peripheral tissues provides the basis for highly practical and efficient tests and diagnostic test kits for the early diagnosis of Alzheimer's disease, as well as providing a biochemical basis for identifying therapeutic targets for drug development. | 2013-10-17 |
20130273546 | LOW TEMPERATURE ENZYME AND METHOD THEREOF - The present invention discloses manufacturing method of low temperature protease and special yeast strain, which can generate low temperature protease in the condition of low temperatures. More particularly, the present invention is to obtain a protease (preferably Cold-adapted protease PI12) using the marine strain of the | 2013-10-17 |
20130273547 | METHOD TO DETERMINE AND CORRECT BASELINE AND TO CHARACTERIZE PCR AMPLIFICATION KINETICS - The disclosed methods correct for high-sloped baseline observed in real-time PCR curves and provides a way of verifying amplification efficiency using a statistical approach. The method teaches the conversion of fluorescent data points to transform the baseline from sloped to horizontal. Then, a 4-parameter logistic model is applied to simulate the PCR kinetics. A cycle number corresponding to a template concentration can then be determined at a inflection point defined by the model | 2013-10-17 |
20130273548 | SAMPLE PREPARATION AND LOADING MODULE - The device has a fluid inlet; a filtering compartment, connected to the fluid inlet and accommodating a filtering matrix in presence of adsorption agents; a fluidic circuit connected downstream of the filtering compartment and including a discharge circuit and a loading circuit; a discharge chamber, connected downstream of the discharge circuit; a preparation outlet, connected downstream of the loading circuit; and suction pumps, connected to the fluidic circuit and configured so as to fluidically connect the filtering compartment alternatively to the discharge circuit or to the loading circuit. | 2013-10-17 |
20130273549 | DETECTION OF EXTRACELLULAR JCV MICRORNAS - JCV-miRNA compositions and methods for detecting glia-derived JCV-miRNA are provided. The compositions and methods of the present invention are particularly useful as a non-invasive biomarker prognostic and/or diagnostic for patients suffering from PML. | 2013-10-17 |
20130273550 | METHODS AND VECTORS FOR CELL IMMORTALISATION - The present invention relates to a method and to vectors for the immortalisation of cells independent of their type. It further relates to a cell or a cell line produced with the method or the vectors of the invention. The invention also relates to the use of this cell or cell line in in vitro applications and in the treatment of disease. | 2013-10-17 |
20130273551 | METHODS FOR IDENTIFYING NUCLEIC ACID LIGANDS - The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate mixture of nucleic acids, in which the nucleic acids have different affinities for the target molecule, and separating in a single step nucleic acids that bind the target molecule with greatest affinity from nucleic acids that bind the target molecule with a lesser affinity and nucleic acids that do not bind the target molecule, thereby identifying the nucleic acid ligand of the target molecule. | 2013-10-17 |
20130273552 | DEVICE AND METHOD FOR PROCESSING TARGET COMPONENT IN TUBE - The present invention provides a small and low running-cost device capable of minimizing the generation of contamination sources as much as possible while performing a series of all the desired manipulations. A device for manipulating a target component in a manipulation tube, comprising: a manipulation tube comprising a tube having an optionally-closeable open end for supplying a sample containing a target component at one end and a closed end at the other end, and a manipulation medium accommodated in the tube and having a gel layer and an aqueous liquid layer multilayered in a longitudinal direction of the tube; magnetic particles that should transport the target component; and magnetic field applying means capable of applying a magnetic field to the manipulation tube to move the magnetic particles in the longitudinal direction of the tube. | 2013-10-17 |
20130273553 | STABILIZATION OF CYCLIC PEPTIDE STRUCTURES - In various aspects, the invention provides methods for cyclizing proteins, including methods for enhancing the stability of cyclized proteins under cytosolic conditions. The invention also provides various methods for using the cyclized proteins. For example, cyclized proteins of the invention may be used in screening assays analogous to the yeast two hybrid assay. Selected embodiments of the invention provide cyclized single chain variable fragment (ScFv) molecules, including molecules in the form of an immunoglobulin fold. | 2013-10-17 |
20130273554 | BIOLUMINESCENT PACKAGING - Some embodiments provided herein relate to bioluminescent packaging, methods of making, and methods of sensing the state of a material, in some embodiments, light emitted by a bioluminescent organism can be used to sense the state of a material. | 2013-10-17 |
20130273555 | Detoxification of Biomass Derived Acetate Via Metabolic Conversion to Ethanol, Acetone, Isopropanol, or Ethyl Acetate - One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism. | 2013-10-17 |
20130273556 | MODULATION OF GENE EXPRESSION BY LOCKED NUCLEIC ACIDS - Disclosed are methods for suppressing or altering gene expression by locked nucleic acids that have high binding affinity for target sequences in genomic DNA. The present methods include a step of recombination to insert a foreign DNA fragment into a specific target site in a genome with greater efficiency than with current techniques. Using a protein to anchor a locked nucleic acid targeting construct at a specific site, DNA recombination between that site and foreign DNA is induced by employing the cell's innate repair machinery. As a result of this recombination, gene transcription can be effectively suppressed. The present methods work in all mammalian cells, and provide a rapid methodology to examine gene function. The foreign DNA can carry markers for ease of screening. The technique is applied in the production of stable cell lines with inserted or deleted genes. | 2013-10-17 |
20130273557 | COMPOUNDS AND METHODS OF MODULATING MITOCHONDRIAL BIOENERGETIC EFFICIENCY THROUGH AN INTERACTION WITH ATP SYNTHASE (COMPLEX V) AND ITS SUBUNITS - The present invention provides, in part, methods of identifying compounds that can bind to an ATP synthase complex, increase bioenergetic efficiency, decrease oxygen consumption or the rate thereof, increase oxygen utilization efficiency, increase cell survival or any combination thereof, and methods of using compounds and/or identified compounds to increase bioenergetic efficiency, increase oxygen utilization efficiency, decrease oxygen consumption, increase cell survival, or any combination thereof. | 2013-10-17 |
20130273558 | Treatment of Conditions Involving Demyelination - The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an Sp35 antagonist. | 2013-10-17 |
20130273559 | PROCESS FOR PREPARING A CHEMICAL STRUCTURE HAVING A PHASE PARTITION, CAPABLE OF GENERATING A SPECIFIC FLUORESCENCE SPECTRUM AND USES THEREOF - The subject matter of the invention is a process for preparing an assembled chemical structure or a mixture of such structures, this structure having a phase partition, wherein the phases are in particular of hydrophobic and hydrophilic nature, such as a composite/synthetic particle or a liposome, and being capable of generating an original fluorescence spectrum. The subject matter of the invention is also said assembled structures and mixture thereof and also the compositions or kit comprising same. The invention also relates to the use of these assembled structures and mixture thereof, in particular for medical imaging in vivo or for in vitro diagnosis of a pathological condition, but also for labelling a sample, an object or a composition that is liquid, or for authentification thereof. The invention also comprises the objects or liquids labelled with the assembled structures, a mixture thereof or with the compositions according to the invention. | 2013-10-17 |
20130273560 | ANALYZING A METABOLITE LEVEL IN A SAMPLE - The invention generally relates to methods for analyzing a metabolite level in a sample. In certain embodiments, methods of the invention may involve obtaining a sample, analyzing the sample using a mass spectrometry technique to determine a level of at least one metabolite in the sample, and correlating the metabolite level with an originating source of the sample, thereby analyzing the sample. | 2013-10-17 |
20130273561 | LIPID ENCAPSULATION OF SURFACE ENHANCED RAMAN SCATTERING (SERS) NANOPARTICLES - Phospholipid-microvesicle-encapsulated surface enhanced Raman scattering (SERS) nanoparticles and methods for making the encapsulated particles are described. The encapsulated particles can be used in nanomedicine. Four Raman-active species were used. A bilayer was observed by TEM, and the SERS spectrum of each dye species (SERS reporter) was confirmed. | 2013-10-17 |
20130273562 | 1L1RL-1 as a Cardiovascular Disease Marker and Therapeutic Target - This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure. | 2013-10-17 |
20130273563 | DEVICE FOR PERFORMING AN ENZYME-BASED DIAGNOSTIC TEST AND METHODS FOR USE THEREOF - Enzyme-based diagnostic testing systems for detecting and quantifying at least one of the activity level or the concentration of an enzyme or a biochemical analyte in a biological sample. Such enzyme-based diagnostic testing systems can provide rapid, accurate, affordable laboratory-quality testing at the point of care. An enzyme-based diagnostic testing system may include a lateral-flow chromatographic assay cassette that is configured for assaying an amount or activity of an enzyme in a sample or for enzymatically determining the concentration of an enzyme substrate in a sample. Additionally, the enzyme-based diagnostic testing systems may include testing devices (e.g., a smartphone or a similar remote computing device) having data collection and data analysis capabilities. Such testing devices may also include automated data reporting and decision support. | 2013-10-17 |
20130273564 | DISPERSION INJECTION METHODS FOR BIOSENSING - I Injection methods for determining biomolecular interaction parameters such in label-free biosensing systems are provided. The methods generally relate to analyte sample injection methods that generate well-defined analyte concentration gradients en route to a sensing region possessing an immobilized binding partner. The injections conditions are generally established according to a set of rules that create a dispersion event that can be accurately modeled by a dispersion term. The dispersion term is incorporated into the desired interaction model to provide a reliable representation of the analyte concentration gradient profile, The resulting interaction model is then fitted to a measured binding response curve in order to calculate the interaction parameters. Thus, the injection methods described herein provide a continuous analyte titration allowing a full analyte dose response to be recorded in a single injection in contrast to the standard multiple injection approach | 2013-10-17 |
20130273565 | POLYMERIC CARRIERS FOR IMMUNOHISTOCHEMISTRY AND IN SITU HYBRIDIZATION - Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers having plural reactive functional groups that react with plural molecules of interest. Reactive functional groups, such as hydrazides, may be derivatized with a variety of detectable labels, particularly haptens. The remaining reactive functional groups may be conjugated directly to a specific binding molecule, such as to the oxidized carbohydrate of the Fc region of the antibody. Disclosed conjugates display large signal amplification as compared to those based on molecules derivatized with single haptens, and are useful for assay methods, particularly multiplexed assays. | 2013-10-17 |
20130273566 | Serological Markers of Inflammatory Bowel Disease Phenotype and Disease Progression - Disclosed are novel biomarkers and methods related to diagnostic tests for the detection and characterization of inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. In particular, the instant invention relates to novel biomarkers and methods of using such biomarkers to predict disease behavior and severity, to differentiate among disease types, and to optimize selection of treatment options in individuals suspected of having an inflammatory bowel disease. | 2013-10-17 |
20130273567 | Screening Method for Candidate Agonist Compounds for Adiponectin Receptor I - A method of screening for candidate compounds for adiponectin receptor 1 agonist including a step of bringing test compounds into contact with cells to determine whether they cause intracellular influx of extracellular calcium ions and selecting, from the test compounds, compounds causing the intracellular influx of extracellular calcium ions as the candidate compounds for adiponectin receptor 1 agonist. | 2013-10-17 |
20130273568 | BENZIMIDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS - The invention relates to benzimidazole-carboxamide 5-HT | 2013-10-17 |
20130273569 | VIOLET LASER EXCITABLE DYES AND THEIR METHOD OF USE - The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates. | 2013-10-17 |
20130273570 | METHOD FOR IDENTIFICATION AND CULTURE OF MULTIPOTENT MESENCHYMAL STEM CELLS WITH HIGH PROLIFERATION POTENTIAL - Variations in the differentiation and lineage potential of stem cells, including mesenchymal stem cells, currently limit their therapeutic use. The ability to identify, isolate, and specifically amplify stem cell populations with desired differentiation potential would contribute the use of stem cells in research and therapy. The present invention discloses a method of assessing differentiation potential of stem cells by measuring the differential expression of antigens CD146 and NG2 on the stem cells. The con elation between CD146 and NG2 expression and differentiation and trilineage potential is explored. The invention also discloses methods to specifically amplify or enrich stem cells with desired differentiation potential, monitor the differentiation potential of a heterogeneous stem cell population, quantify the heterogeneity in differentiation potential of a stem cell culture, and remove stem cells with specific differentiation potentials from a heterogeneous cell culture. | 2013-10-17 |
20130273571 | METHOD OF FUNCTIONALIZING HUMAN RED BLOOD CELLS WITH ANTIBODY - The present invention relates to producing more densely functionalized indicator cells which along, with other components, can be used to detect the presence or absence of antibodies or antigens, by using the A, B, AB and MNS antigens which have a greater degree of expression than the conventionally used D antigen to label the indicator cells with IgG. The present antigen systems have levels of expression that approach one million antigens per cell, which is in great contrast to the conventional D antigen sites of about | 2013-10-17 |
20130273572 | Methods for Diagnosing Lyme Disease - A method for diagnosing Lyme disease status in a mammal is provided. The method entails, in a biological sample obtained or derived from a mammal, determining antibodies to | 2013-10-17 |
20130273573 | AMYLOID BETA AGGREGATES IN CEREBRO SPINAL FLUID AS BIOMARKERS FOR ALZHEIMER'S DISEASE - The invention provides methods for assessing increased probability of having Alzheimer's disease in a subject under assessment including a step of obtaining a measurement of Aβ40 aggregates in a biological sample from the subject, where the biological sample does not include brain tissue, a fraction of brain tissue, or brain homogenate. In some embodiments, the invention relates to methods of assessing increased probability of early stage Alzheimer's disease. The invention further provides methods of assessing increased probability of not having Alzheimer's disease, methods of monitoring disease progression in a subject with Alzheimer's disease, and methods of assigning disease stage for a subject with Alzheimer's disease, and methods of assessing increased probability of MCI progressing to Alzheimer's disease. | 2013-10-17 |
20130273574 | OLIGOMERIC A-BETA IN THE DIAGNOSIS, PROGNOSIS, AND MONITORING OF ALZHEIMER'S DISEASE - The invention provides methods for diagnosis, prognosis and monitoring of Alzheimer's disease. The methods involve measuring the amounts of combined monomeric and oligomeric Aβ and amount of monomeric Aβ in samples obtained from a subject, and determining a ratio. The ratio can be used in diagnosing, prognosing, and/or monitoring Alzheimer's disease. | 2013-10-17 |
20130273575 | Method for Assaying Fibroblast Growth Factor-23 and Assay Reagent - A method for measuring fibroblast growth factor-23 (FGF-23) in a sample, which comprise the following steps:
| 2013-10-17 |
20130273576 | REAGENTS FOR REDUCING LEUKOCYTE INTERFERENCE IN IMMUNOASSAYS - Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that reduce or eliminate the metabolic activity of leukocytes, and performing an immunoassay on the amended sample to determine the concentration of analyte in the sample. Preferably, the sample is amended with one or more enzymes and optionally one or more enzyme substrates and cofactors. | 2013-10-17 |
20130273577 | DETECTION OF DYSPLASTIC OR NEOPLASTIC CELLS USING ANTI-MCM3 ANTIBODIES - Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the preinitiation complex of DNA replication in tissue, cells or fluid. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Test samples include tissue of the cervix (both biopsy and smear samples), breast, colon, lung, bladder, skin, larynx, oesophagus, bronchus, lymph nodes and urinary tract (both biopsy and cytology smear samples), in determination of cancerous and pre-cancerous cellular growth abnormality, and cells spun from urine, blood and serum, in determination of haematological malignancies and evidence of metastatic sarcoma and carcinoma. | 2013-10-17 |
20130273578 | METHOD OF DETECTING CALCIFYING NANOPARTICLES AND SUSCEPTIBILITY TO CALCIFYING NANOPARTICLE FORMATION - A method of measuring the susceptibility of a subject to calcifying nanoparticle formation is disclosed. The method can include obtaining a cell culture comprising peripheral blood mononuclear cells, immune cells, or both, from a peripheral blood mononuclear fraction of a subject in a complete culture media; extracting a first aliquot and a second aliquot from the cell culture; and dispensing the first and second aliquot in different wells. The surface of the well containing the first aliquot can include a calcifying nanoparticle biofilm, while the well containing the second aliquot does not. The first and second aliquots can be incubated and the concentration of osteopontin in each aliquot determined. An osteopontin factor can be calculated and compared to osteopontin factors from a representative sample of other subjects. The osteopontin factor can be defined as the osteopontin concentration in the first aliquot divided by the osteopontin concentration in the second aliquot. | 2013-10-17 |