42nd week of 2014 patent applcation highlights part 43 |
Patent application number | Title | Published |
20140309081 | MOST FIT EXERCISE SLEDGE HAMMER - A sledge hammer with an elongate handle having a longitudinal axis and a flexible generally geometrically uniform removable mass affixed to the handle at a distal end thereof. The mass is secured to the handle with a bolt adapted to extend through the mass and into the distal end of the handle. The bolt is threaded and engages mating threads in the handle. A cone is disposed on the distal end of the handle between the handle and the mass to secure the mass to the handle In the best mode, the mass is a ball which may be perfectly round or have one or more flat surfaces. The ball should have some dampening properties. | 2014-10-16 |
20140309082 | MOBILE, PORTABLE, AND INTERACTIVE EXERCISE APPARATUS - A mobile/portable multifunction and interactive exercise apparatus which may be usable as a mobile/portable striking apparatus and/or a mobile/portable speed bad apparatus, or both. The disclosed embodiments comprise conversion features and components, and utilize an attachment-free leverage application to create a temporary anchoring for the apparatus. Some disclosed embodiments further comprise an electronic interactive user features and components, and utilize impact sensors, a control unit, and a microprocessor for controlling the play of one or more interactive programs/games in which a participant may play against the control unit or against another participant. | 2014-10-16 |
20140309083 | SYSTEM AND METHOD FOR IMPROVING FITNESS EQUIPMENT AND EXERCISE - In a first aspect, a method is provided that includes the steps of (1) providing a monitor for determining a level of exercise performance performed by an exerciser and for outputting a signal representative of the performance level; (2) using the monitor to measure a level of exercise performance performed by an exerciser; (3) outputting from the monitor a signal representative of the performance level; (4) providing a video game having a character, the video game inputting and being responsive to the performance level signal output by the monitor, the video game using the performance level signal to control a performance level of the video game character; and (5) while the exerciser is not exercising, controlling a performance level of the video game character based on a performance level signal output by the monitor. | 2014-10-16 |
20140309084 | Indoor-Outdoor Exercise System - An embodiment of an exercise system includes an exercise monitoring device that gathers data regarding an outdoor exercise routine. Additionally, a remote communication system communicatively connectable to the exercise monitoring device is receptive to the data regarding the outdoor exercise routine such that the remote communication system generates an exercise program based on the data regarding the outdoor exercise routine. Furthermore, an exercise device that is communicatively connectable to the remote communication system may receive the exercise program and simulate one or more aspects of the outdoor exercise routine. | 2014-10-16 |
20140309085 | Indoor-Outdoor Exercise System - An embodiment of an exercise system includes an exercise monitoring device that gathers data regarding an outdoor exercise routine. Additionally, a remote communication system communicatively connectable to the exercise monitoring device is receptive to the data regarding the outdoor exercise routine such that the remote communication system generates an exercise program based on the data regarding the outdoor exercise routine. Furthermore, an exercise device that is communicatively connectable to the remote communication system may receive the exercise program and simulate one or more aspects of the outdoor exercise routine. | 2014-10-16 |
20140309086 | Oblong Orbital Exercising Machine Having Adjustable and Extendable Trace of Movement - An oblong orbital exercising machine includes a main frame, an upright mounted on the main frame, two swinging handles each pivotally connected with the upright, two mounting rods each mounted on the respective swinging handle, two adjusting members each adjustably mounted on the respective mounting rod, a cycle movement mechanism mounted on the main frame, two cranks mounted on the cycle movement mechanism, two links each pivotally connected with the respective adjusting member and the respective crank, two sliding members each slidably mounted on the respective link, two pedals each secured on the respective sliding member, and two driven levers each pivotally connected with the respective mounting rod and the respective sliding member. Thus, the pedals are moved relative to the links to lengthen the forward and backward pace of the user's feet, so that the user's legs are extended. | 2014-10-16 |
20140309087 | EXERCISE APPARATUS WITH A PULL CORD LOOPED ABOUT A CENTRAL PULLEY AND FIRST AND SECOND FREE PULLEYS - An exercise apparatus includes a frame, first and second free pulleys, first and second handle portions, first and second frame pulleys attached to the frame, a central pulley, a pull cord, and a resistance member. The first free pulley includes a first pulley wheel and a first hub with the first pulley wheel configured to rotate in relation to the first hub. The second free pulley includes a second pulley wheel and a second hub with the second pulley wheel configured to rotate in relation to the second hub. The first and second handle portions are in mechanical communication with the first and second hubs with the pulley wheels configured to rotate relative to the handle portions. The pull cord is looped about the pulleys with the resistance member configured to resist movement of the pull cord. | 2014-10-16 |
20140309088 | WEIGHTED ADJUSTABLE FITNESS DEVICE - A weighted adjustable fitness device is disclosed. The device includes a tubular body constructed of a material of a generally rectangular shape. Two edges of the tubular body attached together to form an interior volume. The length of the tubular body is at least an order of magnitude larger than the diameter of the tubular body. The device further includes a reinforcement border attached to or adjacent to the two attached edges of the tubular body. The device may further include a collapsible inlet which is in open communication with the interior volume and which is movable from a first position in which it extends at least partially outward from the tubular body, to a second position in which it extends at least partially inward into the interior volume. The device may further include an end closure. | 2014-10-16 |
20140309089 | ADJUSTABLE WEIGHTED MULTIFUNCTION FITNESS APPARATUS - An adjustable weighted multifunction fitness apparatus and a method of using the adjustable weighted multifunction fitness apparatus are disclosed. The apparatus includes a plurality of panels. The panels are adhered together to form an interior compartment. The apparatus further includes a plurality of shoulder straps configured to be adjustable through the use of a fastener. The apparatus further includes a strap compartment. The apparatus further includes a plurality of handles. The interior compartment includes a plurality of pouches configured to secure one or more deformable exercise articles having a pliable exterior and capable of being reversibly filled with a particulate material or water. | 2014-10-16 |
20140309090 | EXERCISE DEVICE AND METHOD - An exercise device for the pubococcygeus muscle of a male person comprising a support member having two arms and a base, wherein the arms of support member are configurable to fit around the shaft of the penis of a male person so that the base depends from the penis. | 2014-10-16 |
20140309091 | THIGH EXERCISE FITNESS MACHINE - A thigh exercise fitness machine for training outer thigh muscles is a disclosed to include a first base member and a second base member pivotally connected in parallel, a first sliding track and a second sliding track respectively connected to the first base member and the second base member and extending in reversed directions, a first foot plate assembly and a second foot plate member respectively slidably supported on the first sliding track and the second sliding track, two elastic loops respectively coupled between the first foot plate assembly and second foot plate assembly and the first base member and second base member and adapted to store elastic potential energy when the first and second foot plate assemblies are respectively moved along the first and second sliding tracks, enabling the user's lateral thigh muscles to be trained. | 2014-10-16 |
20140309092 | Base System - A base system configured for use in an exercise or physical therapy by a user as a base, the base system includes a first segment and a second segment. Each of the first and second segments includes a portion of cylinder having a surface perpendicular to its central axis and a surface at an incline to its central axis. In forming a base, the first and second segments are arranged such that the second segment is rotatably disposed atop the first segment, where the angle of rotation of the second segment with respect to the first segment causes the resulting base to assume a certain incline. | 2014-10-16 |
20140309093 | SURFBOARD REPLICATING BALANCE BOARD SYSTEM - A balance board adapted for riding rail-to-rail, preferably so that at least a portion of a rider's feet will be placed on the board over the elongated tube. The balance board includes an elongated, planar board having a length that exceeds a width. The balance board further includes two pair of stops mounted to an underside of the board, each pair of stops being mounted near opposite ends of the board, and each stop of the pair of stops being mounted near opposite sides of the board. The balance board further includes a traction region between each stop of each pair of stop. | 2014-10-16 |
20140309094 | DEVICE AND METHOD FOR DETECTING AND/OR DETERMINING THE POSITION OF A BARRIER LAYER CONTAINED IN THE WALL OF A TUBULAR PACKAGING MATERIAL - The invention relates to a device for detecting and/or determining the position of a barrier layer contained in the wall of a tubular packaging material. The device comprises an infrared source and an infrared receiver, said source and said receiver being placed so as to transmit (receive, respectively) infrared radiation through part of the wall of a tube containing a barrier layer to be analyzed. The invention also relates to a method of detecting and/or determining the position of a barrier layer contained in the wall of a tubular packaging material | 2014-10-16 |
20140309095 | DATA EDITING APPARATUS, DATA EDITING METHOD, AND NON-TRANSITORY RECORDING MEDIUM STORING PROGRAM - A data editing apparatus includes a data editing portion for editing grid data in order to generate imposition data, and a fold data editing indicating portion that instructs the data editing portion to edit fold data. In the case that the data editing portion is instructed to edit the fold data by the fold data editing indicating portion, the data editing portion adds the fold data to the imposition data. | 2014-10-16 |
20140309096 | Biological Fluid Collection Device and Biological Fluid Separation System - A biological fluid separation system for a blood sample is disclosed. The biological fluid separation system includes a biological fluid collection device adapted to receive a blood sample and a centrifuge. The centrifuge is adapted to receive the biological fluid collection device such that with the biological fluid collection device received within the centrifuge and a rotational force applied to the biological fluid collection device, a plasma portion of the blood sample is separated from a cellular portion of the blood sample. The biological fluid collection device is only receivable within the centrifuge in one orientation. | 2014-10-16 |
20140309097 | GLASS ELEMENT WITH HIGH SCRATCH TOLERANCE - A glass element is provided that is made of a glass having SiO | 2014-10-16 |
20140309098 | GLASS SUBSTRATE FOR FLAT PANEL DISPLAY - A flat panel display glass substrate includes a glass comprising, in mol %, 55-80% SiO | 2014-10-16 |
20140309099 | LOW IRON, HIGH REDOX RATIO, AND HIGH IRON, HIGH REDOX RATIO, SODA-LIME-SILICA GLASSES AND METHODS OF MAKING SAME - A glass has a basic soda-lime-silica glass portion, and a colorant portion including total iron as Fe | 2014-10-16 |
20140309100 | PROCESS FOR PREPARING CERAMIC POWDERS IN THE PRESENCE OF A SOURCE OF CARBON, POWDERS THUS OBTAINED AND THEIR USE - A method for preparing ceramic powders in the presence of a carbon powder including a step which consists in homogenizing a mixture of particles capable of resulting in a ceramic by heat treatment. Said method can be carried out in the presence of an accelerated solvent and provides, at reduced energy consumption, carbon-coated ceramic powders and then ceramics. | 2014-10-16 |
20140309101 | Polymeric Composition for the Neutralization of Noxious Agents - The present application is directed to a novel composition which acts as a barrier to noxious agents while adding self-detoxifying catalytic treatments to neutralize the noxious and harmful warfare agents when applied for example on a fabric, or other solid support. | 2014-10-16 |
20140309102 | Water Gas Shift Catalyst Operating At Medium Temperature And A Process For Its Preparation - A hydrotalcite-type compound of the formula (I): | 2014-10-16 |
20140309103 | VISIBLE-LIGHT-RESPONSIVE TITANIUM OXIDE MICROPARTICLE DISPERSION, METHOD FOR MANUFACTURING SAME, AND MEMBER HAVING SURFICIAL PHOTOCATALYST THIN FILM FORMED USING SAME DISPERSION - Provided is a visible-light-responsive titanium oxide microparticle dispersion or the like readily enabling manufacture of a highly transparent photocatalyst thin film demonstrating photocatalyst activity even using visible light alone, and having exceptional titanium oxide microparticle dispersion stability even after storage for prolonged periods of time in cold and dark interior locations. The present invention makes it possible to: produce a peroxotitanic acid solution containing vanadium and a tin compound from a titanium compound, a vanadium compound, a tin compound, a basic substance, hydrogen peroxide, and an aqueous dispersion medium as starting materials; subject the peroxotitanic acid solution to a hydrothermal reaction under high pressure; subsequently admix a copper compound into the acid solution; and obtain a visible-light-responsive titanium oxide microparticle dispersion or the like. | 2014-10-16 |
20140309104 | COMPOSITE OXIDE - Provided is a composite oxide which is suitable as a co-catalyst for an exhaust gas purifying catalyst or the like, has high heat resistance, and has an excellent oxygen absorbing and desorbing capability at low temperatures. The composite oxide contains Ce and Zr, wherein the Ce content is 30 to 80 at % and the Zr content is 20 to 70 at %, based on the total of Ce and Zr being 100 at %, or further contains particular element M, wherein the Ce content is not less than 30 at % and less than 80 at %, the Zr content is not less than 20 at % and less than 70 at %, and the content of element M is more than 0 at % and not more than 15 at %, based on the total of Ce, Zr, and element M being 100 at %; wherein the composite oxide has CaF | 2014-10-16 |
20140309105 | METHOD FOR MANUFACTURING HOMOGENEOUS SUPPORTED CATALYST FOR CARBON NANOTUBES - Disclosed is a method for manufacturing a homogeneous supported catalyst for carbon nanotubes. Advantageously, the method induces deep impregnation of a catalyst in micro pores of a support by using high-temperature aging impregnation, thus providing a high CNT yield. | 2014-10-16 |
20140309106 | ALUMINUM SILICATE, METAL ION ADSORBENT, AND METHOD FOR PRODUCING SAME - The aluminum silicate of the invention has: an element ratio of Si and Al, represented by Si/Al, of from 0.3 to 1.0 by molar ratio; a peak at approximately 3 ppm in a | 2014-10-16 |
20140309107 | COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND A FUNGICIDE SELECTED FROM INHIBITORS OF AMINO ACID OR PROTEIN BIOSYNTHESIS AND INHIBITORS OF CELL WALL SYNTHESIS - The present invention relates to a composition comprising at least one biological control agent selected from the group consisting | 2014-10-16 |
20140309108 | SEED TREATMENT COMPOSITION - The present invention relates to novel compositions for treating seeds. Moreover, the present invention is directed to the production of these compositions and the uses of these compositions. | 2014-10-16 |
20140309109 | N-Thio-anthranilamide compounds and their use as pesticides - The present invention relates to N-thio-anthranilamide compounds of the formula (I), the stereoisomers, the salts, the tautomers and the N-oxides thereof, wherein R | 2014-10-16 |
20140309110 | Ternary Herbicidal Compositions Comprising Aminopyralid and Imazamox - Herbicidally active compositions, which comprise 4-amino-3,6-dichloropyridine-2-carboxylic acid (common name: aminopyralid), 2-[(RS)-4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl]-5-methoxymethylnicotinic acid (common name: imazamox)
| 2014-10-16 |
20140309111 | Ternary Herbicidal Compositions Comprising Aminopyralid and Imazamox - Herbicidally active compositions, which comprise 4-amino-3,6-dichloropyridine-2-carboxylic acid (common name: aminopyralid), 2-[(RS)-4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl]-5-methoxymethylnicotinic acid (common name: imazamox) | 2014-10-16 |
20140309112 | HERBICIDALLY ACTIVE OXIME-ETHER-SUBSTITUTED BENZOYLAMIDES - What is described are oxime ether-substituted benzoylamides of the general formula (I) as herbicides. | 2014-10-16 |
20140309113 | Pesticide Composition Having Improved Rainfastness - A pesticide composition includes an active component and polyethyleneimine having a weight average molecular weight of at least about 750,000 g/mol and has improved rainfastness. The polyethyleneimine of this invention has decreased mobility in water as compared to related lower molecular weight analogs. The pesticide composition is formed using a method that includes the steps of providing the active component, providing the polyethyleneimine, and combining the active component and the polyethyleneimine to form the pesticide composition. | 2014-10-16 |
20140309114 | SALTS OF CARBOXYLIC ACID HERBICIDES - Amine salts of certain herbicides that in free acid form include at least one carboxylic acid moiety are described. Herbicide salts comprising the cation of various imidazole, piperazine, piperidine, and morpholine compounds are provided. The herbicide amine salts described are suitable for formulation into herbicidal application mixtures and/or stable concentration compositions that exhibit acceptable volatility characteristics upon application. | 2014-10-16 |
20140309115 | Substituted 1,2,5-oxadiazole compounds and their use as herbicides III - The present invention relates to substituted 1,2,5-oxadiazole compounds of the formula I and the N-oxides and salts thereof and to compositions comprising the same. The invention also relates to the use of the 1,2,5-oxadiazole compounds or of the compositions comprising such compounds for controlling unwanted vegetation. | 2014-10-16 |
20140309116 | SUBSTITUTED 1,2,5-OXADIAZOLE COMPOUNDS AND THEIR USE AS HERBICIDES II - The present invention relates to substituted 1,2,5-oxadiazole compounds of the formula (I) and the N-oxides and salts thereof and to compositions comprising the same. The invention also relates to the use of the 1,2,5-oxadiazole compounds or of the compositions comprising such compounds for controlling unwanted vegetation. Furthermore, the invention relates to methods of applying such compounds. | 2014-10-16 |
20140309117 | SUPERCONDUCTING DIRECT CURRENT TRANSMISSION SYSTEM - A DC superconducting coaxial transmission system provides electrical transmission of 5,000 megawatts of energy while simultaneously delivering liquid hydrogen. The transmission system includes a coaxial transmission segment including an inner superconductor, an outer superconductor disposed in surrounding relation to the inner conductor, and a dielectric insulator disposed between the inner superconductor and the outer superconductor. Liquid hydrogen surrounds the superconductors. Three phase transformers and poly phase rectifier/inverters provide a DC voltage source to the superconductors from the electrical grid. In one embodiment, a switching circuit connected between the voltage source and the superconductor injects a cancellation current component into the direct current flow. The cancellation current component is polarized to flow in a direction opposite to the direct current flow to produce a current zero, thus enabling safe interruption of the high DC current while minimizing the magnitude of transient voltages during switching. | 2014-10-16 |
20140309118 | METHOD OF PREPARING NUCLEIC ACID MOLECULES - Provided is a method of preparing nucleic acid molecules comprising: (a) a step of providing nucleic acid fragments constituting at least a portion of the complete sequence of a target nucleic acid; (b) tagging the nucleic acid fragments with barcode sequences; (c) identifying the sequence of the nucleic acid fragments tagged by the barcode sequences; and (d) recovering desired nucleic acid fragments among the sequence-identified nucleic acid fragments using the barcode sequences. | 2014-10-16 |
20140309119 | Methods and Devices for High Fidelity Polynucleotide Synthesis - Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products. | 2014-10-16 |
20140309120 | METHOD AND SUBSTRATE FOR NUCLEIC ACID AMPLIFICATION, AND METHOD AND APPARATUS FOR NUCLEIC ACID ANALYSIS - The present invention relates to a method for nucleic acid amplification, which enables clusters of amplified nucleic acid fragments to be sequenced by a sequencer to be formed at a high density and improves throughput of nucleic acid sequence analysis by amplifying the number of nucleic acids in the cluster to 10,000 molecules or more; and a method for nucleic acid amplification for enhancing read accuracy, which achieves a high cluster density and increases the number of the amplified fragments in the cluster by the steps of previously forming a pattern of primer DNAs on a base material and fixing bulky template DNA molecules synthesized from DNA samples thereon to induce amplification reaction. | 2014-10-16 |
20140309121 | Categorisation Of Biological Deposits Using Matrix Assisted Laser Desorption Ionisation Mass Spectrometry - A method of categorising a human according to pre-determined categories using Matrix Assisted Laser Desorption Ionisation Mass Spectrometry (MALDI-MS) is disclosed. A method is provided to discriminate humans based on gender, for example, by comparing MALDI-MS sample spectral data in the m/z range 2,000 to 30,000 and comparing these sample spectral data with reference spectral data obtained from pre-categorised humans. | 2014-10-16 |
20140309122 | KNOWLEDGE-DRIVEN SPARSE LEARNING APPROACH TO IDENTIFYING INTERPRETABLE HIGH-ORDER FEATURE INTERACTIONS FOR SYSTEM OUTPUT PREDICTION - Systems and methods are disclosed for Knowledge-Driven Sparse Learning to Identify Interpretable High-Order Feature Interactions. This is done by generating one or more functional groups from gene features and gene and protein interaction grouping; selecting informative genes and functional interactions that exhibit differential patterns for the target disease and to generate a reduced feature space; and searching exhaustively on the reduced feature space by examining all possible pairs of interacting features (and possibly higher-order feature interactions) to identify combination of markers and complex patterns of feature interactions that are informative about the phenotypes in a sparse learning framework to select informative interactions and genes. | 2014-10-16 |
20140309123 | METHODS FOR LUNG CANCER CLASSIFICATION - The present invention provides specific nucleic acid sequences for use in the identification, classification and diagnosis of various sub-types of lung cancers. The present invention permits one to accurately classify lung cancers based on their miR expression profile without further manipulation. Using microRNA microarray data generated from over two hundred formalin-fixed paraffin-embedded (FFPE) resection samples, fine needle aspiration (FNA) samples and fine needle biopsy (FNB) samples of primary lung cancer, microRNA expression profiles were identified that differ significantly for various sub-types of lung cancer. | 2014-10-16 |
20140309124 | METHODS FOR ASSESSING ATHEROGENESIS BY DETERMINING OXIDIZED PHOSPHOLIPID TO APOLIPOPROTEIN B RATIOS - The present invention provides methods to analyze oxidized phospholipids (OxPL) on apolipoprotein B-100 in patients at high risk or with documented coronary artery disease (CAD) or acute coronary syndromes (ACS) such as unstable angina and acute myocardial infarction or suspected of being at risk for ACS. Such methods are useful for diagnostic purposes and for monitoring the effects of dietary interventions or with drugs such as statins. More particularly, the disclosure provides methods for determining OxPL/apoB ratios as indices of atherosclerosis regression and plaque stability. | 2014-10-16 |
20140309125 | MARKERS RELATED TO AGE-RELATED MACULAR DEGENERATION AND USES THEREFOR - Described herein are compositions, kits and methods for diagnosing and tracking the progression of AMD in a subject by detecting the presence or absence of particular lipid metabolism markers associated with AMD. Predictive computer models of disease risk are also disclosed. | 2014-10-16 |
20140309126 | PEPTIDE BINDING TO GRAPHITIC MATERIALS AND PHAGE INCLUDING SAME - The present disclosure provides a peptide including one or more amino acid sequence selected from a group consisting of SEQ ID NO 1 and SEQ ID NO 2 and binding specifically to a graphitic material, a phage including same, and a graphitic material including a graphitic surface on which the peptide or the phage is arranged. | 2014-10-16 |
20140309127 | METHODS OF DETECTING BLADDER CANCER - Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of detecting low grade bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting androgen receptor (AR) and/or uroplakin 1B (UPK1B). | 2014-10-16 |
20140309128 | DIGITAL ASSAYS FOR MUTATION DETECTION - Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate. | 2014-10-16 |
20140309129 | Encoded Nanopore Sensor for Multiplex Nucleic Acids Detection - The present invention provides a new and improved multiplexed oligonucleotide detection method based on the nanopore technology with one or more probes containing a sequence with complementarity to the target oligonucleotide, a terminal extension at the probe's 3′ terminus, 5′ terminus, or both termini and a label attached to the terminus. The improved probes and probe sets enable sensitive, selective, and direct multiplex detection, differentiation and quantification of distinct target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method based on miRNA levels in the patient's tissue sample. | 2014-10-16 |
20140309130 | Use of MicroRNAs for Screening and Diagnosis of Prostate Cancer and Benign Prostatic Hyperplasia - Disclosed are microRNA biomarkers and use thereof for screening and diagnosis of prostate cancer and benign prostatic hyperplasia. This invention provides a method for screening for prostate cancer in a subject involving the steps of: (a) assaying the miRNA expression level in a test sample from the subject to be screened for prostate cancer; (b) comparing the assayed miRNA expression level of the subject to the miRNA expression level in a normal sample providing a control relative to the test sample of the subject; and (c) computing the differential expression of the miRNA from the subject, wherein the over-expression of miR-1825 or under the expression of miR-484 is indicative of prostate cancer. In another aspect, provided is a method for screening for benign prostatic hyperplasia in a subject involving the steps of: (a) assaying the miRNA expression level in a test sample from the subject to be screened for benign prostatic hyperplasia; (b) comparing the assayed miRNA expression level of the subject to the miRNA expression level in a normal sample providing a control relative to the test sample of the subject; and (c) computing the differential expression of the miRNA from the subject, wherein the under expression of miR-498 is indicative of benign prostatic hyperplasia. | 2014-10-16 |
20140309131 | METHOD FOR SCREENING INDUCED PLURIPOTENT STEM CELLS - The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers. | 2014-10-16 |
20140309132 | METHOD FOR QUANTITATIVELY SENSING AND EFFECTIVELY MARKING INTERACTION WITH TARGET MATERIAL BY USING ENERGY TRANSFER AND SIGNAL CHANGE BASED ON HIGH-DENSITY DISPLAY OF MATERIAL - The present invention relates to methods of quantitatively analyzing and detecting interactions, which effectively occur between detector materials displayed on a nano-assembly matrix at high density, and sensitively labeling and isolating a target material that effectively interacts with the detector materials, by the use of energy transfer and signal changes that effectively occur in label molecules displayed at high density. Specifically, the present invention relates to a method of quantitatively detecting the interactions between various bioactive materials, which occur in vitro or in vivo, based on high-density displays of molecules, and to a method of sensitively labeling a target material that interacts with these bioactive materials. | 2014-10-16 |
20140309133 | Novel Method for Diagnosis of High-Affinity Binders and Marker Sequences - The present invention relates to a novel method for diagnosing high-affinity binders, in particular antibodies or autoantibodies, and the identification, characterisation and selection of marker sequences and diagnostic use thereof, in particular in the form of a panel. The invention also relates to a singleplex assay in which the discovered selection of marker sequences is used in the form of a panel and high-affinity binders are detected using a single signal. | 2014-10-16 |
20140309134 | EXCHANGE-INDUCED REMNANT MAGNETIZATION FOR LABEL-FREE DETECTION OF DNA, MICRO-RNA, AND DNA/RNA-BINDING BIOMARKERS - A method of using an exchange-induced remnant magnetization (EXIRM) technique for label free detection of short strands of nucleotides and cancer biomarkers, such as DNA and microRNA strands, DNA/RNA-binding biomarkers, and cancer-specific antigens, with high sensitivity, high specificity, and broad dynamic range. The method may provide a label-free approach aimed to facilitate high reliability, and to require a minimum amount of biochemical reagents. | 2014-10-16 |
20140309135 | REMEDY FOR DIABETES - A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc. | 2014-10-16 |
20140309137 | GENE EXPRESSION PROFILES ASSOCIATED WITH LEAN PHENOTYPE AND USES THEREOF - Gene expression profiles associated with improved or maintained lean body mass or reduced body fat are disclosed. The gene expression profiles were determined in adipose, liver, and muscle tissue of animals subjected to lean-promoting regimens such as consumption of a high protein diet, ingestion of conjugated linolenic acid, and/or increased exercise. Methods of using such profiles for the identification of pharmaceutical substances, nutraceutical substances, dietary substances, or treatment regimens that modulate or contribute to desired phenotypes in animals are also disclosed | 2014-10-16 |
20140309138 | COMPOSITIONS AND METHODS OF DETECTING RESPIRATORY PATHOGENS USING NUCLEIC ACID PROBES AND SUBSETS OF BEADS - The present disclosure is instructional for a multiplex nucleic acid amplification assay to detect and identify multiple respiratory pathogens. | 2014-10-16 |
20140309139 | GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS IN WOMEN, METHODS OF DETECTION AND USES THEREOF - Methods and kits for identifying a woman having an increased risk of developing venous thrombosis, requiring prophylactic or therapeutic treatment are provided, and methods for identifying an agent useful in prophylactically or therapeutically treating venous thrombosis in women, said methods comprising genotyping the woman with respect to the F9 G32023A (rs440051) polymorphism and/or the F9 5:32164:6/4 polymorphism (rs35599944). | 2014-10-16 |
20140309140 | METHOD FOR THE DIAGNOSIS OF NIEMANN-PICK DISEASE - The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject. | 2014-10-16 |
20140309141 | Methods of Screening for Inhibitors of Enzymes - Methods and compositions for detection of the modulators of proteolytic enzymes, particularly cysteine proteases, are disclosed. | 2014-10-16 |
20140309142 | METHOD OF ON-CHIP NUCLEIC ACID MOLECULE SYNTHESIS - A method of synthesizing a nucleic acid molecule, such as a gene, on a substrate or microchip is described. In particular, a method for synthesizing, amplifying, and assembling DNA oligonucleotides into a nucleic acid molecule or gene product, on a single substrate or microchip is described. Also described are a method of correcting a sequence error in a synthesized nucleic acid molecule, as well as a method for synthesizing and screening a library of codon variants to identify a nucleic acid molecule with an optimized level of protein expression. | 2014-10-16 |
20140309143 | CENTROID MARKERS FOR IMAGE ANALYSIS OF HIGH DENSITY CLUSTERS IN COMPLEX POLYNUCLEOTIDE SEQUENCING - Improved compositions, methods, apparatus, and kits for high-throughput nucleic acid amplification, detection and sequencing are disclosed. A nucleic acid cluster having an identifiable center is produced by generating on a solid support an immobilized nucleic acid complement from a template, one of which comprises a detectable label; and amplifying the complement and the template to obtain a nucleic acid cluster on the support, the cluster having a substantially central location marked by the detectable label and a surrounding region comprising immobilized copies. Also disclosed are nucleotide sequence determination in nucleic acid clusters so produced, center position annotation in the clusters, assignment of sequence information to overlapping clusters, and related compositions and methods. | 2014-10-16 |
20140309144 | NANOPORE SEQUENCING USING CHARGE BLOCKADE LABELS - The invention relates to devices and methods for nanopore sequencing. The invention includes compositions and methods of nucleic acid sequencing using a single polymerase enzyme complex comprising a polymerase enzyme and a template nucleic acid attached proximal to a nanopore, and nucleotide analogs in solution comprising charge blockade label that are attached to the polyphosphate portion of the nucleotide analog such that the charge blockade labels are cleaved when the nucleotide analog is incorporated into a growing nucleic acid and the charge blockade label is detected by the nanopore to determine the presence and identity of the incorporated nucleotide and thereby determine the sequence of a template nucleic acid. | 2014-10-16 |
20140309145 | HIGH THROUGHPUT METHOD FOR ASSEMBLY AND CLONING POLYNUCLEOTIDES COMPRISING HIGHLY SIMILAR POLYNUCLEOTIDIC MODULES - The present invention relates to a method for the assembly and cloning of polynucleotides comprising highly similar polynucleotidic modules, that is highly versatile, does not require intermediate amplification step and can be easily automated for high throughput production of customized polynucleotidic modules. | 2014-10-16 |
20140309146 | Emulsions and methods usable within a wellbore - Emulsions usable within a wellbore as drilling fluids can be prepared by providing an emulsion base that includes a crude biodiesel product, and adding an emulsifying subsystem to the emulsion base. Solid particles in the emulsifying subsystem migrate to interfaces between continuous and discontinuous components in the emulsion base to define phases of the emulsion. A weighting agent can be added, as needed, to provide the emulsion with a suitable mud weight for use in a particular wellbore. Usable crude biodiesel products can include the unmodified product of a transesterification reaction, that include a continuous ester phase and a discontinuous alcohol phase without requiring separation or modification. Usable emulsifying subsystems can be prepared in situ. Use of esters, clays, and/or alcohols can enable reduction or elimination of water, brine, and petrochemicals in the emulsions. | 2014-10-16 |
20140309147 | SPREAD CROSSLINKER AND METHOD OF WATER CONTROL DOWNHOLE - A crosslinker composition including a spread crosslinker for treating a subterranean formation is provided along with methods of sealing a subterranean formation including introducing a crosslinkable fluid, the crosslinkable fluid containing a spread crosslinker and a crosslinkable component, into a subterranean formation. | 2014-10-16 |
20140309148 | SPREAD CROSSLINKER AND METHOD - A crosslinker composition including a spread crosslinker for treating a subterranean formation is provided along with methods of sealing a subterranean formation including introducing a crosslinkable fluid, the crosslinkable fluid containing a spread crosslinker and a crosslinkable component, into a subterranean formation. | 2014-10-16 |
20140309149 | Dual Function Proppants - Proppants for use in fractured or gravel packed/frac packed oil and gas wells are provided with a contaminant removal component to remove one or more of the contaminants found in subterranean water/hydrocarbon from a production well. The water/hydrocarbon cleaning proppant solids may be used as discrete particles in a proppant formulation, as a coating on proppant solids in pores of a porous proppant solid or as part of the proppant's internal structure. The contaminant removal component removes contaminants, especially dissolved contaminants, in the subterranean water or hydrocarbon before the water/hydrocarbon leaves the well. For those contaminant removal components that can be regenerated, such as ion exchange resins, a measured quantity of an acidic regeneration solution can be injected into the fractured stratum for regeneration and recovered when the well resumes production. | 2014-10-16 |
20140309150 | LUBRICANT COMPOSITION - A lubricant composition and a method of lubricating off-road vehicles and/or machinery. The lubricant composition includes (i) a base oil, (ii) at least one ashless component (A) having the structure P(═S)(SR | 2014-10-16 |
20140309151 | 1-OCTENE/1-DECENE COPOLYMER AND LUBRICATING-OIL COMPOSITION CONTAINING SAME - Provided are an α-olefin copolymer useful as a high-viscosity lubricant oil excellent in viscosity characteristics, low-temperature characteristics and oxidation stability, and a lubricant oil containing the copolymer. The α-olefin copolymer is a 1-octene/1-decene copolymer produced by the use of a doubly bridged metallocene catalyst. | 2014-10-16 |
20140309152 | PNEUMATIC TOOL LUBRICANT - A lubricant for reducing or eliminating airborne lubricant exhaust mist in ambient air when used by a tool driven by compressed air. The lubricant includes between about 58 vol % and about 90 vol % polyalphaolefin or polyalphaolefin blend, and between about 10 vol % and about 42 vol % complex ester compatible with the polyalphaolefin or polyalphaolefin blend. The ester includes polymeric molecules with a cohesive tendency to adhere to each other, and when subjected to shear stresses, to form elongate filaments. | 2014-10-16 |
20140309153 | NAIL POLISH REMOVER COMPOSITION AND ITS USE - The present invention relates to a water based nail polish remover composition comprising an anionic surfactant, a water soluble solvent, and water; wherein the anionic surfactant is selected from the group consisting of secondary C | 2014-10-16 |
20140309154 | PERSONAL CARE COMPOSITION COMPRISING A PRE-EMULSIFIED FORMULATION - The present invention is directed to a personal care composition comprising a pre-emulsified emulsion comprising from about 0.25% to about 80% of one or more materials selected from the group comprising metathesized unsaturated polyol esters, sucrose polyesters, fatty esters with a molecular weight greater than or equal to 1500 and mixtures thereof or, by weight of said hair care composition; wherein an emulsifier is selected from the group consisting of anionic, non-ionic, cationic, amphoteric and mixtures thereof wherein the average particle size of the pre-emulsified emulsion is from about 20 nanometer to 20 microns; from about 5% to about 50% of one or more anionic surfactants, by weight of said hair care composition; at least about 20% of an aqueous carrier, by weight of said hair care composition wherein the composition is stable with respect to one of the following measures selected from emulsion particle size, viscosity or visual phase separation and mixtures thereof. | 2014-10-16 |
20140309155 | HIGH PERFORMANCE LOW VISCOELASTICITY FOAMING DETERGENT COMPOSITIONS EMPLOYING EXTENDED CHAIN ANIONIC SURFACTANTS - The invention meets the needs above by providing a surfactant system, mixture or blend that can be used as a part of a soaking composition. The surfactant system is capable of forming emulsions with, and thus removing, oily and greasy stains. In a preferred embodiment the surfactant compositions of the invention can remove non-trans fat and fatty acid stains. The invention involves foaming soaking compositions that have some or part of the anionic surfactant present in the same replaced with an extended chain anionic surfactant. | 2014-10-16 |
20140309156 | APE Free Cleaning Composition with Reduced VOC - The present disclosure provides a composition comprising at least one primary branched nonionic surfactant of Formula (I) wherein x is an integer from 1 to 11, y is an integer from 0 to 25, R | 2014-10-16 |
20140309157 | WNT FAMILY-DERIVED PEPTIDES AND USE THEREOF - The present invention relates to a WNT-derived novel peptide and use thereof. WNT-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT protein, and has much higher stability and skin penetration potency than natural-occurring WNT protein. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT signal transduction pathway-related disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics. | 2014-10-16 |
20140309158 | COMPOSITIONS AND METHODS FOR IMMUNOMODULATION - The invention relates to methods and reagents for the treatment of immunological diseases. In particular, the invention relates to isoforms of the C4b-binding protein (C4BP) lacking beta chains as well as to fragments and peptides derived thereof and to the uses of these polypeptides for the treatment of immunological diseases such as immunoinflammatory disease, sepsis, an autoimmune disease, transplant rejection, graft-versus-host disease and a hypersensitivity disease. Moreover, the invention relates also the use of factor H for the treatment of immunological diseases. In addition, the invention relates to tolerogenic dendritic cells obtained using the C4BP isoform lacking beta chain, the peptides and fragments thereof and factor H and to the therapeutic uses of said cells. | 2014-10-16 |
20140309159 | COMPOSITIONS AND METHODS FOR TARGETING NUCLEAR IMPORT SHUTTLES AND TREATING INFLAMMATORY DISORDERS - The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (NTM) and/or at least one importin alpha-selective NTM, and/or at least one importin alpha-specific NTM, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation. | 2014-10-16 |
20140309160 | PLANT DISEASE CONTROL AGENT - The present invention relates to a plant disease control agent containing a compound represented by the following formula (1) or salt thereof as an active ingredient (in the formula, R | 2014-10-16 |
20140309161 | Modified antibiotic peptides having variable systemic release - The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all. | 2014-10-16 |
20140309162 | NOVEL ANTIBACTERIAL AND FUNGICIDAL PEPTIDE IN WHICH LYSINE AND TRYPTOPHAN RESIDUES ARE REPEATED, AND USE THEREOF - The present invention relates to an antibacterial and fungicidal peptide in which a lysine and tryptophan dipeptide is repeated. More specifically, the antibacterial and fungicidal peptide of the present invention, in which lysine and tryptophan dipeptide is repeated four times, shows excellent antibacterial activities with respect to gram-positive bacteria, gram-negative bacteria and antibiotic-resistant strains by affecting the inner membrane of harmful microorganisms, has remarkable fungicidal activities with respect to pathogenic fungi and antibiotic-resistant fungi, and shows little cytotoxicity, and thus can be useful for a pharmaceutical composition, a cosmetic composition, agricultural chemicals, a food preservative, a cosmetic preservative, and a pharmaceutical preservative. | 2014-10-16 |
20140309163 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN - The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins. | 2014-10-16 |
20140309164 | DEUTERATED NUCLEOSIDE PRODRUGS USEFUL FOR TREATING HCV - Deuterated nucleoside analogs of Formula (I) and the pharmaceutically acceptable salts thereof are provided by this disclosure | 2014-10-16 |
20140309165 | USE OF 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES FOR TREATING LIVER DISORDERS - The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as amino-transferases. The 1,3-diphenylprop-2-en-1-one derivatives of General Formula (I) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease. | 2014-10-16 |
20140309166 | Derivatisation of Erythropoietin (EPO) - The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds. | 2014-10-16 |
20140309167 | COMBINATION OF ACTIVE INGREDIENTS FOR THE TREATMENT OF ACUTE KIDNEY INJURY - The present invention relates to a new combination for the treatment of renal damage, in particular of acute renal failure and acute kidney injury, the pharmaceutical compositions and the kits containing it and their use in therapy. | 2014-10-16 |
20140309168 | MODIFIED PEPTIDES AND PROTEINS - Provided are compounds and methods of making compounds containing two or three groups derived from a peptide, such as enfuvirtide or exenatide, covalently bound to a linker. The compounds may contain polyethylene glycol groups to enhance solubility and pharmacokinetic properties. The compounds are useful for the treatment of diseases or conditions subject to treatment with the parent peptide, such as HIV and AIDS in the case of enfuvirtide, or diabetes in the case of exenatide. | 2014-10-16 |
20140309169 | Methods and Compositions for Inhibiting Delayed Graft Function - Disclosed are compositions and methods for inhibiting preventing, reducing delayed graft function, allograft rejection or ischemia reperfusion injury. | 2014-10-16 |
20140309170 | ANTI-ANGIOGENIC PEPTIDES AND USES THEREOF - Provided are peptide sequences derived from prostate serum antigen (PSA). The peptides are provided in cyclic and linear form. Methods for using the peptides for inhibition of angiogenesis, such as angiogenesis in a tumor, are provided. | 2014-10-16 |
20140309171 | MARKER FOR BLOOD COAGULATION - The invention relates to the use of phosphorylated Acetyl-CoA carboxylase (ACC) in platelets from a subject as a biomarker for blood coagulation, preferably blood coagulation in the subject, preferably encompassing activation of the coagulation cascade as well as platelet activation, preferably thrombin-induced platelet activation. The invention encompasses uses and methods for the diagnosis or the monitoring of blood coagulation in the subject. The invention further relates to uses and methods for screening for anti-coagulants or pro-coagulants. | 2014-10-16 |
20140309172 | ICE INHIBITING COMPOUNDS AND USES THEREOF - The present disclosure identifies caspase-1/ICE as a therapeutic target for α-synuclein associated diseases and disorders. Related methods and compositions are also provided. | 2014-10-16 |
20140309173 | Peptides For Skin Rejuvenation And Methods Of Using The Same - The invention provides compositions for stimulating the formation of one or more extracellular matrix components that contain a lipoaminoacid derivative of the tripeptide carnosine such as N-Octanoyl Carnosine. Also provided are compositions containing N-Octanoyl Carnosine in combination with selected tripeptide and/or tetrapeptides as well as pharmaceutical and/or cosmetic compositions containing such compositions. The invention further provides methods of using the compositions and compositions of the invention to treat, alleviate, and/or ameliorate a symptom, condition, disorder, or disease of the skin or mucosa, wherein the symptom, condition, disorder, or disease is associated with changes in extracellular matrix components. | 2014-10-16 |
20140309174 | HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER - The present invention provides compounds having formula (I): | 2014-10-16 |
20140309175 | POLYMERIC CONJUGATES OF C1-INHIBITORS - Polymer conjugates containing a C1-inhibitor having at least one substantially non-antigenic polymer covalently attached to the C1-inhibitor via thiol group of the C1 inhibitor is provided. In the polymer conjugates of the present invention, the substantially non-antigenic polymer is attached to either free thiol from a cysteine of thiol generated from disulfide bonds in C1 inhibitor. Alternatively, the substantially non-antigenic polymer is attached to one of more thiols in C1 inhibitor via bifunctional spacer. In addition, methods of making the conjugates as well as methods of treatment using the conjugate of the present invention are also provided. | 2014-10-16 |
20140309176 | ETHANOL DEPENDENCE OF ALPHA1 ANTITRYPSIN C-TERMINAL LYS TRUNCATION BY BASIC CARBOXYPEPTIDASES - The present invention provides methods of preparing alpha-1-antiproteinase inhibitor and controlling the amount of des-lys alpha-1-antiproteinase inhibitor in the preparation, and compositions comprising the same, as well as methods of treatment using the same. | 2014-10-16 |
20140309177 | COMPOSITIONS AND METHODS FOR THE INDUCTION AND TUNING OF GENE EXPRESSION - Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes. | 2014-10-16 |
20140309178 | INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 - Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: | 2014-10-16 |
20140309179 | Treatment of Glaucoma and Other Retinopathies with Gangliosides - A method of treating or preventing a retinopathy such as glaucoma in a human patient in need thereof comprising administering one or more gangliosides to the patient. | 2014-10-16 |
20140309180 | XANTHURENIC ACID DERIVATIVE PHARMACEUTICAL COMPOSITIONS AND METHODS RELATED THERETO - The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I | 2014-10-16 |
20140309181 | TREATMENT OF DISEASES RELATED TO ALPHA SUBUNITS OF SODIUM CHANNELS, VOLTAGE-GATED (SCNxA) WITH SMALL MOLECULES - Small compounds that modulate the expression of and/or function of sodium channel, voltage-gated, alpha subunit (SCNxA) are presented. Pharmaceutical compositions containing such small molecules and their use in treating diseases and disorders associated with the expression of SCNxA are also presented. | 2014-10-16 |