42nd week of 2009 patent applcation highlights part 39 |
Patent application number | Title | Published |
20090258826 | Pituitary adenylate cyclase activating peptide (PACAP) receptor (VPAC2) agonists and their pharmacological methods of use - This invention provides novel peptides that function in vivo as agonists of the VPAC2 receptor. These insulin secretagogue polypeptides are shown to lower blood glucose in vivo more than controls upon glucose challenge. The polypeptides of this invention are also stable in formulation and have long half-lives. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, in particular type 2 diabetics. In particular, the invention is a polypeptide selected from a specific group of VPAC2-related polypeptides, or functional equivalents thereof. The invention is also directed to a method of treating a metabolic disease in a mammal comprising administering a therapeutically effective amount of the insulin secretagogue peptides to said mammal. Also disclosed are methods of making the peptides, both recombinant and synthetic. | 2009-10-15 |
20090258827 | Transcription Factor Modulator - The present invention relates to novel agents that are useful for modulating transcription factor activity. In particular, the present invention relates to A transcription factor modulator comprising (i) a pharmaceutically-effective amount of a HLS-5 polypeptide, isoform thereof, functional fragment thereof or pharmaceutical composition thereof; or (ii) a compound or composition capable of regulating the endogenous levels of HLS-5 or its activity; or (iii) combinations thereof. | 2009-10-15 |
20090258828 | INVESTIGATION OF MUCOSA DRYNESS CONDITIONS - The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition. | 2009-10-15 |
20090258829 | NEW FORMULATION FOR INCREASING BIOAVAILABILITY OF NEURTURIN - The present invention relates to formulations with protein growth factors, particularly neurturin as active ingredients and low molecular weight polyanionic excipients having increased bioavailability. | 2009-10-15 |
20090258830 | DIAGNOSTIC AND THERAPEUTIC USES OF GELSOLIN IN RENAL FAILURE - The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis). | 2009-10-15 |
20090258831 | TREATMENT USING NEUBLASTIN POLYPEPTIDES - The invention relates to treatments of neuropathic pain, including tactile allodynia, and to treatments for reducing loss of pain sensitivity associated with neuropathy. The present treatments involve the use of neublastin (NBN) polypeptides. | 2009-10-15 |
20090258832 | Cytokines and Cytokine Receptors With Reduced Immunocencity - The present invention provides methods for the identification of CD4 | 2009-10-15 |
20090258833 | FORTIFIED LIQUID PROTEIN COMPOSITIONS AND METHODS OF MAKING SAME - A fortified liquid protein composition and method includes hydrolyzed collagen and a desired abundance of sulfur containing amino acids and optionally taurine. | 2009-10-15 |
20090258834 | Plasma protein-binding ligands - The invention provides an isolated or purified peptide that binds at least one plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more than 10 amino acids, and comprises an amino acid sequence Xaa | 2009-10-15 |
20090258835 | COMPOUNDS THAT STIMULATE GLUCOSE UTILIZATION AND METHODS OF USE - The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells: | 2009-10-15 |
20090258836 | EFFECTIVE DELIVERY OF CROSS-SPECIES A3 ADENOSINE-RECEPTOR ANTAGONISTS TO REDUCE INTRAOCULAR PRESSURE - Provided are methods for reducing intraocular pressure in an individual having an ocular disorder causing elevated intraocular pressure, such as glaucoma. The method comprises administering to the individual an effective intraocular pressure-reducing amount of a pharmaceutical composition comprising an A | 2009-10-15 |
20090258837 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation - The invention relates to analogous compounds of 6-thioguanosine triphosphate of general formula (I). A compound of the general formula (I); wherein the dashed bond in the sugar moiety can be either single or double and wherein R1, R2, R3, R4 or R5, equal or different between each other, have general formula -(Int) | 2009-10-15 |
20090258838 | GEL FORMULATION - The present invention relates to a sterile gel formulation comprising calcium gluconate. It also relates to a sterilisable gel formulation comprising calcium gluconate, which is stable under gamma-radiation sterilisation conditions, and also to the use of these formulations in, for example, treating burns caused by exposure of a human or animal body to hydrofluoric acid, either in liquid or vapour form. | 2009-10-15 |
20090258839 | COMPOSITIONS COMPRISING CHITOSAN SUITABLE FOR COMPREHENSIVE THERAPEUTIC TREATMENT OR COMPREHENSIVE PREVENTION OF THE METABOLIC SYNDROME - The present invention relates to compositions comprising chitosan, in the form of drugs or food supplements, suitable for comprehensive therapeutic treatment or comprehensive prevention of the metabolic syndrome. Also described is their preparation. More generally, the invention concerns the use of chitosan for comprehensive therapeutic treatment or comprehensive prevention of the metabolic syndrome. | 2009-10-15 |
20090258840 | METHOD AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES - A compound of formula (1), and/or its salts, tautomers or solvates is used to treat hematological malignancies. In an embodiment, an organic acid salt of compound 1 is provided for general use in treatment of neoplasms, and in a further embodiment the salt is stabilized with carbohydrate. | 2009-10-15 |
20090258841 | COMPOSITIONS AND METHODS FOR SKIN CARE - Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes. | 2009-10-15 |
20090258842 | 7-Phenyl-Substituted Tetracycline Compounds - 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. | 2009-10-15 |
20090258843 | Compositions Containing Antiviral Compounds and Methods of Using the Same - The present invention is directed to compositions and methods for the treatment of various diseases, pathological disorders, and medical conditions such as viral infections and cancer. The compositions include (A) an antiviral compound or a pharmaceutically acceptable salt thereof; and (B) an agent selected from the group consisting of a substituted or unsubstituted imidazole or a pharmaceutically acceptable salt thereof; a non-steroidal anti-inflammatory agent or a pharmaceutically acceptable salt thereof; an amino acid or a pharmaceutically acceptable salt thereof; a carboxylic acid or a pharmaceutically acceptable salt thereof; a sulfonic acid or a pharmaceutically acceptable salt thereof; and a combination thereof. | 2009-10-15 |
20090258844 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISORDERS OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS - The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and materials for treating seizure and seizure disorders, epilepsy, status epilepticus, migraine, spreading depression, intracranial hypertension; for treating the pathophysiological effects of head trauma, stroke, ischemia and hypoxia; for treating or protecting from the pathophysiological effects of neurotoxic agents such as ethanol; and for treating neuropsychiatric disorders and central nervous system edema by administering agents that modulate ionic concentrations and/or ionic gradients in the brain, particularly ion-dependent or cation-chloride cotransporter antagonists. Electrolyte cotransport antagonists and combinations of such compositions with other agents for treating various conditions are disclosed. | 2009-10-15 |
20090258845 | Combination Dosage Forms and Therapies for Supporting Bone Health - Combined therapies and oral dosage forms based on genistein for the support of osteoporotic health. | 2009-10-15 |
20090258846 | Eyebrow re-growth stimulator for re-growth of lost eyebrows - A chemical composition and method of an eyebrow re-growth stimulator for women who has lost there eyebrows due to dease and treatments. The lose of harmons and other causes such as in ageing women population. The eyebrow regrowth composition methods of topical treatment in an effective amount of the treatment which emploes a vasodilator in combination with estradiol and/or a 5-a-reductase inhibitor in a pharmaceutically acceptable vehicle. The compositions and methods of the invention are suitable for the treatment of lost eyebrows whereby the promotion of re-growth is increased. | 2009-10-15 |
20090258847 | Cholanic Acid Amides - 4-(3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid amides wherein the nitrogen of the amide group is substituted by a sulfonylaminocarbonyl-(C | 2009-10-15 |
20090258848 | BIOMARKERS FOR INFLAMMATORY BOWEL DISEASE - The present invention relates to methods of determining inflammatory bowel disease status in a subject. The invention further relates to kits for determining inflammatory bowel disease status in a subject. The invention further related to methods of identifying biomarker for determining inflammatory bowel disease status in a subject. | 2009-10-15 |
20090258849 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS - The invention relates to new steroids nitrooxyderivatives, to topical pharmaceutical formulations thereof, and their use for treating skin or mucosal membrane diseases or disorders. These new steroids nitrooxyderivatives have an improved pharmacological activity and enhanced local tolerability. | 2009-10-15 |
20090258850 | STABILIZED THERAPEUTIC COMPOSITIONS AND FORMULATIONS - The invention relates to pharmaceutically acceptable formulations comprising an active pharmaceutical ingredient such as androst-5-ene-3β,17β-diol, androst-5-ene-3β,7β,17β-triol or derivatives of either of these compounds and an air oxidizable excipient that have been stabilized with respect to efficacy. Use of the efficacy-stabilized formulations to treat a number of conditions or symptoms thereof, such as a symptom associated with exposure to radiation is described. | 2009-10-15 |
20090258851 | DIARYL SUBSTITUTED ALKANES - The instant invention provides compounds of Formula II which are 5-lipoxygenase activating protein inhibitors. | 2009-10-15 |
20090258852 | Inhibitors of Checkpoint Kinases - The instant invention provides for compounds which comprise benzoisoquinolinones and aza derivatives that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer. | 2009-10-15 |
20090258853 | Somatostatin Agonists - This invention relates to compounds which are agonists of somatostatin and selective toward somatostatin receptor subtype SSTR2. The compounds are useful in the treatment and prevention of diabetes, and diabetes-related pathologies, including retinopathy, neuropathy and nephropathy. Many of the compounds are orally active. Thus, it is an object of this invention to describe such compounds. It is a further object to describe the specific preferred stereoisomers of the somatostatin agonists. A still further object is to describe processes for the preparation of such compounds. Another object is to describe methods and compositions which use the compounds as the active ingredient thereof. | 2009-10-15 |
20090258854 | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase - Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity. | 2009-10-15 |
20090258855 | BICYCLIC TRIAZOLES AS PROTEIN KINASE MODULATORS - The present disclosure provides bicyclic triazole protein kinase modulators and methods of using these compounds to treat diseases mediated by kinase activity. | 2009-10-15 |
20090258856 | IMIDAZOPYRIDAZINONE AND IMIDAZOPYRIDONE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS - The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula | 2009-10-15 |
20090258857 | CHEMICAL COMPOUNDS - The present invention encompasses compounds of general formula (1) wherein R | 2009-10-15 |
20090258858 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS - Muscarinic Acetylcholine receptor antagonists and methods of using them are provided. | 2009-10-15 |
20090258859 | METRONIDAZOLE COCRYSTALS AND IMIPRAMINE COCRYSTALS - Cocrystals of metronidazole are described herein. Such cocrystals are a cocrystal of metronidazole with gentisic acid and a cocrystal of metronidazole with gallic acid. Cocrystals of imipramine hydrochloride are also described. Such cocrystals are a cocrystal of imipramine hydrochloride with (+)-camphoric acid, a cocrystal of imipramine hydrochloride with fumaric acid, and a cocrystal of imipramine hydrochloride with 1-hydroxy-2-naphthoic acid. | 2009-10-15 |
20090258860 | XANTHINE DERIVATIVES FOR THE TREATMENT OF VASCULAR DEPRESSION - Methods and compositions are provided for treating vascular depression. The methods involve administering to a subject in need thereof a xanthine derivative in a therapeutically effective amount to treat vascular depression, particularly the xanthine derivatives pentoxifylline or propentofylline. The methods may further include administration of an additional therapeutic agent in combination with the xanthine derivative selected from the group consisting of a selective serotonin reuptake inhibitor (SSRI), a serotonin-norepinephrine reuptake inhibitor (SNRI), and a drug used in the treatment of cerebrovascular disease. Compositions of the invention include pharmaceutical compositions and kits for treating vascular depression in a subject in need thereof that include therapeutically effective amounts of a xanthine derivative and an additional therapeutic agent selected from the group consisting of an SSRI, an SNRI, and a drug used in the treatment of cerebrovascular disease. | 2009-10-15 |
20090258861 | Tetrahydronaphthyridine Derivatives - The present invention relates to tetrahydronaphthyridine derivatives of the general formula (I): | 2009-10-15 |
20090258862 | Niacin receptor agonists, compositions containing such compounds and methods of treatment - Compounds of the formula (I): as well as pharmaceutically acceptable salts and solvates are disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included. | 2009-10-15 |
20090258863 | Method for treatment of amyotrophic lateral sclerosis using talampanel - A method of treating a human patient afflicted with amyotrophic lateral sclerosis (ALS) comprising periodically administering to the human patient for a therapeutically effective duration a pharmaceutical composition comprising an amount of talampanel therapeutically effective to provide a benefit to the human patient, thereby treating the human patient. | 2009-10-15 |
20090258864 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES - This invention is directed to compounds of formula (I): | 2009-10-15 |
20090258865 | ADMINISTRATION OF BENZODIAZEPINE COMPOSITIONS - The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions. | 2009-10-15 |
20090258866 | CGRP Receptor Antagonists - The disclosure generally relates to the novel compounds of formula I, including their salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD). | 2009-10-15 |
20090258867 | PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST - The present invention provides a pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of the following formula [I]: in which R | 2009-10-15 |
20090258868 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I | 2009-10-15 |
20090258869 | METHODS AND COMPOUNDS FOR TREATMENT OR PREVENTION OF SUBSTANCE-RELATED DISORDERS - The present disclosure provides methods of treating or preventing a substance-related disorder using Hsp90 inhibitors, Hsp90 modulators, tyrosine hydroxylase modulators, and modulators that reduce the interaction between Hsp90 and tyrosine hydroxylase. | 2009-10-15 |
20090258870 | NOVEL ANSAMITOCIN DERIVATIVES - Provided are among other things ansamitocin derivatives, pharmaceutical compositions comprising these novel ansamitocin derivatives, methods for the production of the ansamitocin derivatives and their use for the treatment of cancer. | 2009-10-15 |
20090258871 | Aza-Substituted Spiro Derivatives - A compound of the following formula (I) or its pharmaceutically-acceptable salt is provided: | 2009-10-15 |
20090258872 | USE OF ARYL-SUBSTITUTED POLYCYCLIC AMINES AS MEDICAMENTS - The invention relates to therapeutic use of aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; | 2009-10-15 |
20090258873 | Novel tetrahydropyridothiophenes - Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity. | 2009-10-15 |
20090258874 | PYRAZOLO-HETEROARYL COMPOUNDS - A compound of formula I | 2009-10-15 |
20090258875 | Fungicide Hydroximoyl-Tetrazole Derivatives - The present invention relates to hydroximoyl-tetrazole derivatives of formula (I) wherein T represent a tetrazolyl substituents, A represents a carbo- or heterocycle, L | 2009-10-15 |
20090258876 | NOVEL INDOL CARBOXYLIC ACID BISPYRIDYL CARBOXAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD AND COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT - Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT | 2009-10-15 |
20090258877 | TRIAZOLOTRIAZINES AND TRIAZOLOPYRAZINES AND THEIR USE - The invention relates to substituted triazolotriazines and triazolopyrazines and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular haematologic disorders, preferably of leukopenias and neutropenias. | 2009-10-15 |
20090258878 | TRIAZINE DERIVATIVE COMPOUND AND COMPOSITION FOR TREATING CANCER CONTAINING THEM - The present invention relates to a Triazine derivative compound, pharmaceutically acceptable salt thereof and a pharmaceutical composition containing them. Compound or composition of the present invention is useful for cancer treatment, and especially has superior effect in breast cancer treatment. | 2009-10-15 |
20090258879 | METHOD FOR TREATING CANCER, RHEUMATOID ARTHRITIS AND OTHER MEDICAL DISEASES BY UTILIZING MODIFIED VIRUS VIRIONS TO INSERT MEDICATIONS INTO TARGETED CELLS - A safer, more effective treatment of many medical diseases may be approached by a method utilizing modified viruses as vehicles to transport medically therapeutic drug molecules to specific cells in the body with the intent to have the drug exert an effect only on those cells to which the modified virus delivers the drug. The modified virus or virus-like structures make contact with specific target cells by means of the modified virus's exterior probes or virus-like structures' exterior probes. Once the exterior probes engage a target cell's receptors, the modified virus or virus-like structure inserts into the target cell the quantity of medically therapeutic drug molecules it is carrying. By delivering the medically therapeutic drug only to specific cells in the body it is assured the drug reaches the site in the body it will be most beneficial and the occurrence of unwanted side effects due the drug are significantly minimized. | 2009-10-15 |
20090258880 | Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions - Substituted tetrahydropyrrolopyrazine compounds corresponding to formula I | 2009-10-15 |
20090258881 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT - The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; | 2009-10-15 |
20090258882 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors - The invention relates to compounds of the formula I, | 2009-10-15 |
20090258883 | 1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds - Compounds of formula (I): | 2009-10-15 |
20090258884 | Substituted amides - Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver. | 2009-10-15 |
20090258885 | Diphenylmethane Derivatives as Inhibitors of Leukotriene Biosynthesis - The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. | 2009-10-15 |
20090258886 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES - The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other conditions or disorders associated with kinases. | 2009-10-15 |
20090258887 | Novel Carboxylic Acid Derivatives - The present invention is concerned with novel arylalkyl carboxylic acid derivatives, more specifically, with acylates of arylalkyl carboxylic acids with naturally occurring, non-toxic hydroxy, sulfhydryl, amino or imino compounds, and to compositions containing them. The compositions are preferably cosmetic preparations. | 2009-10-15 |
20090258888 | Pyrimidine Derivatives - This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer. | 2009-10-15 |
20090258889 | PESTICIDAL COMPOSITIONS - The present disclosure relates to pesticidal compositions and to methods for controlling pests such as insects and other arthropods. More particularly, the disclosure relates to a pesticidal compositions containing mineral oil and one or more additional components which, when used in combination, act synergistically to control insect and pest populations. | 2009-10-15 |
20090258890 | TOPOISOMERASE-TARGETING AGENTS - The invention provides compounds of formula I or formula II: | 2009-10-15 |
20090258891 | Macrocyclic Compounds As Antiviral Agents - The present invention relates to macrocyclic compounds of formula (I): wherein W, n, R | 2009-10-15 |
20090258892 | FUSED PYRAZOLE DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF - The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. | 2009-10-15 |
20090258893 | FUSED QUINOLINE DERIVATIVE AND USE THEREOF - The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I) | 2009-10-15 |
20090258894 | Fused Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes - The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. | 2009-10-15 |
20090258895 | PHARMACEUTICAL FORMULATION AND PROCESS COMPRISING A SOLID DISPERSION OF MACROLIDE (TACROLIMUS) - The present invention relates to a pharmaceutical formulation and process for preparing the same comprising an oral dosage formulation, such as a capsule formulation, of a macrolide compound, such as tacrolimus, wherein the capsule formulation contains both a solid dispersion of the macrolide along with a non-dispersed form of the macrolide. The pharmaceutical formulation according to the invention is bioequivalent to the FDA approved product according to a bioavailability study conducted in humans. | 2009-10-15 |
20090258896 | COMPOSITION COMPRISING AT LEAST ONE HIGHER ALIPHATIC ALCOHOL AND AN EXTRACT OF GRIFFONIA SIMPLICIFOLIA - Novel compositions comprising a combination of at least one higher primary aliphatic alcohol preferably selected from those having 18 to 40 carbon atoms or mixtures thereof, at least one source of 5-hydroxytryptophan (5-HTP) optionally additionally comprising a source of caffeine and/or catechin-polyphenol and/or epigallocatechin gallate as active agents, either alone or in combination with other active agent(s), optionally with one or more excipient(s) are provided. Particularly, the invention relates to compositions and process for preparation of such compositions and method of use thereof for the management of obesity and associated disorders. | 2009-10-15 |
20090258897 | Substituted benzimidazoles - Disclosed herein are substituted benzimidazole-based proton pump modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 2009-10-15 |
20090258898 | AMIDES OF ACETIC AND PROPIONIC ACIDS - The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory. | 2009-10-15 |
20090258899 | DERIVATIVES OF PYRROLIZINE, INDOLIZINE AND QUINOLIZINE, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - The disclosure relates to a compound of formula (I): | 2009-10-15 |
20090258900 | AMIDE DERIVATIVE - Amide derivatives represented by the formula (I): | 2009-10-15 |
20090258901 | LIGANDS FOR MONOAMINE RECEPTORS AND TRANSPORTERS, AND METHODS OF USE THEREOF - One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters. | 2009-10-15 |
20090258902 | BIPHENYL-PYRAZOLECARBOXAMIDE COMPOUNDS - The present invention relates to biphenyl-pyrazole compounds and in particular biphenyl-pyrazolecarboxamides. The invention further provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by antagonism or inverse agonism of the CB | 2009-10-15 |
20090258903 | Aminoethane Sulfonamide Orexin Receptor Antagonists - The present invention is directed to aminoethane sulfonamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved. | 2009-10-15 |
20090258904 | Epithiolone Analogues - Epothilone analogues include a molecular scaffold which holds at least one segment of epothilone in a predetermined orientation and which rigidities a region between the macrolactone ring and the aromatic side-chain. | 2009-10-15 |
20090258905 | PHOSPHODIESTERASE-4 INHIBITORS BELONGING TO THE TERTIARY AMINE CLASS - Compounds of formula (I): | 2009-10-15 |
20090258906 | CXCR2 ANTAGONISTS - The invention relates to compounds of the formula I | 2009-10-15 |
20090258907 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES - Disclosed herein are compounds of formula (I) or pharmaceutical acceptable salts thereof, | 2009-10-15 |
20090258908 | Crystalline S-Omeprazole Strontium Hydrate, Method For Preparing Same, And Pharmaceutical Composition Containing Same - This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same. | 2009-10-15 |
20090258909 | Novel Benzimidazole Derivatives Useful as Selective Androgen Receptor Modulators (SARMS) - The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. | 2009-10-15 |
20090258910 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, lck, SAPK2α, p38, TGFβ, KDR, c-Kit, b-RAF, c-RAF, FLT1 and FLT4 kinases. | 2009-10-15 |
20090258911 | COMPOSITION AND METHOD FOR TREATING FIBROTIC DISEASES - The present invention discloses 5-methyl-1-(substituted phenyl)-2(1H)-pyridones have enhanced anti-fibrotic activities than 5-methyl-1-(non-substituted phenyl)-2(1H)-pyridones. An representative example of 5-methyl-(1-substituted phenyl)-2(1H)-pyridones is 1-(3′-fluorophenyl)-5-methyl-2(1H)-pyridone. Accordingly, there are provided compositions comprising one or more compounds selected from the group consisting of 5-methyl-1-(substituted phenyl)-2(1H)-pyridones and methods of using the same to treat or prevent fibrosis diseases. | 2009-10-15 |
20090258912 | N-(1-Alkyl-2-Phenylethyl)-Carboxamide Derivatives and Use Thereof as Fungicides - A compound of general formula (I): | 2009-10-15 |
20090258913 | Triazole Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 - Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM. | 2009-10-15 |
20090258914 | Inhibitor of Anti-Apoptotic Proteins - A compound having the structure A is described as well as the use of such compounds to inhibit at least one BCL-2 protein family member. | 2009-10-15 |
20090258915 | RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE - Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases. | 2009-10-15 |
20090258916 | Low-melting biocidal formulation - A low-melting biocidal composition comprising 4,5-dichloro-2-octyl-3(2H)-isothiazolone, 3-iodopropargyl-N-butyl carbamate and at least one C | 2009-10-15 |
20090258917 | Benzoxazoles Useful in the Treatment of Inflammation - There is provided the use of a compound of formula I, | 2009-10-15 |
20090258918 | EP4 receptor agonist, compositions and methods thereof - This invention relates to potent selective agonists of the EP | 2009-10-15 |
20090258919 | Pharmaceutical formulations and use thereof in the prevention of stroke, diabetes and / or congestive heart failure - The present invention relates to use of an inhibitor of the renin-angiotensin system (RAS) or a pharmaceutically acceptable derivative thereof, such as ramipril or ramiprilat, in the prevention of stroke, diabetes and/or congestive heart failure (CHF). | 2009-10-15 |
20090258920 | INJECTABLE FORMULATION OF ANTIBIOTIC AND SOLUTION FOR INTRAVENOUS ADMINISTRATION THEREOF - A pharmaceutical composition for injection comprising a depsipeptide antibiotic, WAP-8294A | 2009-10-15 |
20090258921 | INDOLE DERIVATIVES - Novel indole derivatives of formula (I) or a pharmaceutically acceptable salt thereof: | 2009-10-15 |
20090258922 | COMPOUND EXHIBITING PGD2 RECEPTOR ANTAGONIST - A compound having CRTH2 receptor antagonism, represented by the following formula (I). The compound is useful for the treatment of allergic diseases having a relation to eosinophils and the like. | 2009-10-15 |
20090258923 | Carrier Composition for Nucleic Acid Transport - An object of the present invention is to provide a nucleic acid delivery carrier composition of low toxicity and high safety, the carrier composition, when used to administer a nucleic acid such as an siRNA into an animal-derived cell or organism, being capable of delivering efficiently the nucleic acids into the cells while protecting it from being degraded; and a nucleic acid deliver composition containing the carrier and a nucleic acid. | 2009-10-15 |
20090258924 | METHODS, COMPOSITIONS AND DRUG DELIVERY SYSTEMS FOR INTRAOCULAR DELIVERY OF siRNA MOLECULES - Biocompatible intraocular drug delivery systems in the form of an implant for intraocular administration of siRNA molecules. The drug delivery systems may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy among others. | 2009-10-15 |
20090258925 | NATURAL ANTISENSE AND NON-CODING RNA TRANSCRIPTS AS DRUG TARGETS - Small interfering RNA (siRNA) knock down antisense transcripts, and regulate the expression of their sense partners. This regulation can either be discordant (antisense knockdown results in sense transcript elevation) or concordant (antisense knockdown results in concomitant sense transcript reduction). | 2009-10-15 |