41st week of 2010 patent applcation highlights part 40 |
Patent application number | Title | Published |
20100261562 | Football with Aerodynamic Lace - Lace designs for footballs are provided. The laces have geometries that improve the aerodynamic characteristics of the football during flight. Additionally, the placement of the laces on the football is selected to maximize aerodynamic performance of the football during flight. | 2010-10-14 |
20100261563 | NOVEL TENNIS BALL - Tennis ball which comprises an elastomeric polyurethane foam having a ball shape and a density of 250-800 kg/m | 2010-10-14 |
20100261564 | ROTARY TENSIONER - An assembly for maintaining tension in a drive belt features a housing mounted on a base. The housing contains a biasing element that exerts torque on the housing to bias the housing. An arm is connected to the housing and rotates with the housing in response to the bias of the biasing element. A pulley is connected to the lever arm and engages a drive belt in response to the bias force of the biasing element on the lever arm. The pulley deflects the shape of the belt to provide tension in the belt. A sealing element provides prevents migration of debris into the housing and provides a biasing force to impede translatory movement of a first half of the housing from a second half of the housing, while allowing rotation of the first half relative to the second half. | 2010-10-14 |
20100261565 | DUAL-MODE ELECTROMECHANICAL VARIABLE SPEED TRANSMISSION APPARATUS AND METHOD OF CONTROL - The current invention discloses a dual-mode electro-mechanical variable speed transmission. Said transmission includes an input shaft, an output shaft system, a planetary gear system having at least three co-axial rotating members, two electric machines along with the associated controllers for the electric machines, and at least a clutch. Said planetary gear system has at least three branches; each branch corresponds to a co-axial rotating member. The first branch couples to the first electric machine with a fixed speed ratio; another branch couples to the input shaft with a fixed speed ratio; and yet anther branch couples to the output shaft system with a fixed speed ratio; the second electric machine couples selectively to two of the branches in the planetary gear system with different speed ratios. Said two branches are not the first branch and one of the said two branches is connected to the output shaft system. Said dual-mode electro-mechanical variable speed transmission is capable of providing at least two power splitting operation modes, including an output power splitting mode. Different operation modes cover different speed ratio regimes. At the mode switching point, the corresponding clutch or clutches is automatically synchronized. Thus the speeds of the rotation members of the transmission are continuous, and the transmission is free from shock loads at the operating mode switching point. In addition, said transmission is capable of providing operations with at least a fixed input-to-output speed ratio. | 2010-10-14 |
20100261566 | ELECTRIC DRIVE FOR A MOBILE VEHICLE - An electric drive for a mobile vehicle comprises an electric motor ( | 2010-10-14 |
20100261567 | ECCENTRICALLY OSCILLATING SPEED REDUCER - There is provided an eccentrically oscillating speed reducer capable of reducing a number of parts more than that of a background art. | 2010-10-14 |
20100261568 | GEAR TRAIN WITH SPLIT TORQUE - A gear train is provided that includes at least one side gear comprising a helical face gear and a plurality of helical pinions in meshing engagement with the helical face gear. The gear train may further include an absorber configured to provide an axial force on at least one of the plurality of helical pinions. A differential may also be provided including a differential case and a gear train disposed in the differential case. The gear train includes at least one side gear comprising a helical face gear and a plurality of helical pinions in meshing engagement with the helical face gear. The gear train in the differential may further include a means for providing an axial force on at least one of the plurality of helical pinions. | 2010-10-14 |
20100261569 | FRONT DIFFERENTIAL FOR A VEHICLE - A front differential for a four wheel drive vehicle, includes: a switching mechanism that switches the vehicle between rear-wheel drive and front- and rear-wheel drive by selectively interrupting or allowing the transmission of power between one of a pair of side gears and one of a pair of front wheels; and an urging mechanism that urges at least one of the pair of side gears in a drive shaft axial direction toward at least one of the front wheels. | 2010-10-14 |
20100261570 | HUB TRANSMISSION ASSEMBLY - A multi-speed internal bicycle hub transmission assembly includes a stationary hub axle, a driver, a hub shell, a power transmission mechanism and a shift control mechanism. The stationary hub axle includes a positioner that is movable in a radial direction. The driver and the hub shell are rotatably supported to the hub axle. The power transmission mechanism is operably disposed between the driver and the hub shell for transmitting rotational power from the driver to the hub shell through a plurality of power transmission paths. The shift control mechanism includes a pawl control member movable in rotational directions relative to the hub axle to a plurality of orientations. Each orientation corresponds to selection of a corresponding one of the plurality of power transmission paths of the power transmission mechanism. The positioner is disposed to urge the pawl control member to remain the selected orientation. | 2010-10-14 |
20100261571 | Planetary reduction gear apparatus - This apparatus includes: a sun gear having external teeth; planetary gears, each having external teeth and configured to be meshed with the sun gear; planetary shafts, each being a rotation shaft of the planetary gear; a ring gear having internal teeth and configured to be meshed with the planetary gears; and a planetary carrier including an annular base plate and an annular back plate. The planetary carrier supports the planetary shafts between the annular base plate and the annular back plate and determines a relative position between planetary gears. The annular base plate is integrally formed with one end of the planetary shaft to support the one end. The annular back plate supports the other end of the planetary shaft. At least one of the planetary shaft and the planetary carrier has lower stiffness in its part adjacent to the one end of the planetary shaft than stiffness of its part adjacent to the other end thereof. | 2010-10-14 |
20100261572 | GEAR MECHANISM, PARTICULARLY PLANET GEAR WITH A FLANGE AND A RING GEAR - The invention relates to a gear mechanism with at least a flange for the adaptation of the gear mechanism to a drive component and with at least one ring gear, which is firmly connected on the gear side to the flange. It is advantageous to use a connection where the flange presents at least a radial flange bore, the ring gear presents at least a radial ring gear bore, and a pin is led through a pair consisting of such a radial flange bore and such a radial ring gear bore, and in the process the flange and the ring gear are braced firmly against each other. In particular, the flange bore and the ring gear bore are arranged with at least partial overlap in the axial direction and simultaneously partial mutual offset by an offset difference. | 2010-10-14 |
20100261573 | BEVEL FRICTION RING GEARING AND METHOD FOR MOUNTING OR PRODUCING A BEVEL FRICTION RING GEARING - The aim of the invention is to further develop a bevel friction ring gearing. The invention thus relates to a bevel friction ring gearing in which the friction ring can be displaced by means of an adjusting device that comprises a guide on which an adjusting bridge for the friction ring is arranged in a free axially displaceable manner. The adjusting device comprises a worm-gear drive that engages with the guide. | 2010-10-14 |
20100261574 | AUTOMATIC TRANSMISSION WITH NORMALLY ENGAGED DISC CLUTCHES - An automatic variable transmission with normally engaged disc clutches includes a main transmission pump connected to the transmission and at least one clutch located within the transmission. The clutch is in an engaged position when the main transmission pump is not operating. The clutch assembly includes a piston moveable between an engaged position and a disengaged position and at least one spring is operably connected to the piston. The piston is operable to move the at least one spring between the engaged position and a disengaged position. A plurality of clutch plates may transfer torque when the at least one spring is in the engaged position. | 2010-10-14 |
20100261575 | MULTI-SPEED DUAL-CLUTCH TRANSMISSION FOR A HYBRID VEHICLE - A dynamically-shiftable multi-speed dual-clutch transmission (DCT) for operative connection to an engine and to an electric motor in a hybrid vehicle is provided. The DCT includes a first clutch, a second clutch and a third clutch. The first clutch is configured to transmit torque of the engine and withstand energy of the vehicle at launch from rest. The second clutch is configured to select a first set of forward speed ratios. The third clutch is configured to select a second set of forward speed ratios alternating with the speed ratios of the first set. The second and third clutches are each configured to withstand combined torque of the electric motor and torque of the engine during shifts into the respective set of forward speed ratios, but not to withstand torque of the engine at launch or energy of the vehicle at launch. | 2010-10-14 |
20100261576 | ENGINE ROTATIONAL SPEED CONTROL APPARATUS - An engine rotational speed control apparatus is provide to prevent a degradation of fuel efficiency caused by an unnecessary increase of the rotational speed of an engine when a depression amount of an accelerator pedal is briefly increased and then immediately decreased. In particular, when the vehicle is accelerated, an optimum fuel efficiency operating point along an optimum fuel efficiency curve is not moved immediately to another optimum fuel efficiency operating point corresponding to a new target drive force. Instead, the target drive force is reached by increasing the engine load while increasing the engine rotational speed as little as possible, and thus using an operating point that does not lie on the optimum fuel efficiency curve. | 2010-10-14 |
20100261577 | Gear Shift Control of a Dual Clutch Transmission - A method for controlling a gear shift of a dual clutch transmission having an offgoing clutch and an oncoming clutch, includes using torque transmitted by the oncoming clutch to control torque at a transmission output, using a speed of a power source to control a transfer of torque between the offgoing clutch and the oncoming clutch, and varying said torque capacity to produce a target slip across the oncoming clutch when the shift is completed. | 2010-10-14 |
20100261578 | Friction Element Load Sensing in an Automatic Transmission - A load sensor assembly for measuring an amount of torque transmitted through a torque establishing element includes a core mounted on a transmission housing and a load sensor mounted on the core. The load sensor is positioned against a portion of the torque establishing element whereby a portion of the amount of torque transmitted through the torque establishing element travels through the load sensor and is measured. A cable is connected to the load sensor for transmitting a signal representative of the amount of torque to a transmission controller. | 2010-10-14 |
20100261579 | Sensing Apparatus for Use with Exercise Bicycles - A sensing apparatus for use in combination with a stationary bicycle comprises a housing that supports a source of emitted radiation and a detector of radiation of the same wavelength as that emitted by the source, fixing means for fixing the housing to an exercise device such that radiation is emitted towards a region of space that can be occupied by a part of a body of a user of the exercise device and selectively transmitted on to the detector depending on whether a part of a user's body is located within the space, a processor which measures at least one property of the radiation from the source that is passed to the detector and from the measured property produces an output signal indicative of the proximity of the user relative to the device within that space | 2010-10-14 |
20100261580 | Process And Apparatus For Exercising An Operator - A process is disclosed for enabling an operator to exercise on an exercise device. The process includes measuring a range of movement of the operator during exercising on the exercise device for generating an electronic range of movement data. A strength is measured of the operator during exercising on the exercise device for generating an electronic strength data. An electronic program is designed based on the electronic range of movement data and the electronic strength data. The electronic program is stored in an electronic media. The electronic program is displayed as a moving scale on a screen for instructing the operator to exercise at the same rate as the moving scale to complete the exercise in a timely and controlled matter. | 2010-10-14 |
20100261581 | HAND EXERCISE DEVICE - A hand exercise device | 2010-10-14 |
20100261582 | EXERCISE DEVICE AND METHOD OF USE - An exercise device has a negative heel. A left and a right exercise device, mirroring each other, are placed on an exercisers feet. In one method, a heel to toe step, grab & flex sequence is repeated, while wearing a pair of the exercise devices. In another method of exercising, a squat, ballet squat or calf raise is repeated, while wearing a pair of the exercise devices. | 2010-10-14 |
20100261583 | PORTABLE FOOT AND ANKLE EXERCISE APPARATUS AND ASSOCIATED METHODS - A foot, toe, and ankle exercise device provides variable resistance to movements of the foot, ankle and toes in multiple directions. Embodiments of the device comprise a flexible forefoot support to allow for full toe and foot range of motion. Resistance is provided by resistance members that may comprise elastic banding or tubing. The forefoot support may be suspended by the resistance members. | 2010-10-14 |
20100261584 | Heavy bag with semi-rigid peripheral exterior for martial arts training - A heavy bag for use by martial arts practitioners to practice the martial arts, the heavy bag adapted to receive a sheath about its circumferential periphery, the sheath having a plurality of vertically longitudinal sleeves or pockets for the slidable receipt of semi-rigid tubes, rods, or pellets which would therefore be disposed about the circumference of the heavy bag and when struck by a martial arts practitioner with a select anatomical body part would toughen and desensitize the particular anatomical body part. In the preferred embodiment, the sheathing would be in two parts, a lower sheathing secured about the lower portion of the heavy bag by means of hook and loop fastener means, and an upper sheathing which would depend from the four point linkage used for hanging the heavy bag, the lower portion of the upper sheathing being secured by hook and loop fasteners about the circumference of the heavy bag. Alternatively, the sheath may be permanently attached to the heavy bag and sold and used as only a body conditioner bag. | 2010-10-14 |
20100261585 | Biomechanical stimulation training method and apparatus - A method for implementing biomechanical stimulation training includes application of a preselected dynamic force concurrent with a local proprioceptive stimulus at an engagement member and performing at least one dynamic training activity. The method also includes applying a preselected isometric training force concurrent with another local proprioceptive stimulus at the engagement member, and performing an isometric training activity. An apparatus to facilitate performance of dynamic and isometric training activities includes an engagement member structured to facilitate operative engagement with a portion of a person's body, a force generation assembly structured to generate dynamic and isometric training forces at the engagement member, and a vibration generation assembly structured to generate local proprioceptive stimuli at the engagement member. | 2010-10-14 |
20100261586 | Exercise apparatus - An exercise apparatus is disclosed for strength training and physical therapy of a user thereof. The apparatus includes a frame having a first side and a second side spaced relative to the first side and at least one spacer extending between the sides. An axle is rotatably supported by the frame, the axle having a first and a second end. An arm has a first and a second extremity, the first extremity of the arm being rigidly secured to the first end of the axle. A handle extends from the second extremity of the arm such that in use of the apparatus, when the user moves the handle in an orbital direction about the axle, the axle is rotated relative to the frame. A weight table is movably supported by the frame. A weight guide extends from the weight table for permitting weights to be guided onto the weight table. A first table support has a proximal and a distal end, the proximal end being pivotally secured to the frame at a first location, the distal end being pivotally secured to the weight table at a first disposition. A second table support has a first and a second termination, the first termination being pivotally secured to the frame at a second location spaced relative to the first location. The second termination is pivotally secured to the weight table at a second disposition, the second disposition being spaced relative to the first disposition. The arrangement is such that, in use of the apparatus, the weight table is moved from a first position adjacent to the frame to a second position away from the frame. The weight table is inclined relative to the frame when in the first position thereof for facilitating guiding weights onto and along the weight guide onto the weight table. The weight table is disposed substantially horizontal when in the second position thereof. A transmission is provided for transmitting rotational movement of the axle when the axle is rotated relative to the frame, the rotational movement of the axle being transmitted to the weight table for moving the weight table between the first position and the second position thereof. | 2010-10-14 |
20100261587 | SELECTORIZED DUMBBELL HAVING A SELECTOR COMPRISING A PIN HAVING FORK-SHAPED CONNECTING PRONG(S) - A selectorized dumbbell has a handle that can be inserted into a gap between stacks of nested left and right weight plates. A selector determines how many left weight plates are coupled to the left end of the handle and how many right weight plates are coupled to the right end of the handle. Each weight plate is held between a pair of flexible arms on a forked carrier. The arms allow the weight plates to deflect out of a normal, substantially upright, orientation if an impact shock is delivered to the dumbbell. The arms are restored to their normal orientation once the impact shock dissipates. Alternatively, the weight plates may comprise a metallic inner weight plate covered with an elastomer encasement and with an integral elastomer lug attaching the weight plates to at least one interconnecting member. The selector may comprise a connecting pin with at least one flexible shock absorbing prong. | 2010-10-14 |
20100261588 | LEG STRETCHING EXERCISE APPARATUS - A leg stretching exercise apparatus includes a base seat, a telescopic handle erectly projecting from the front of the base seat, pulley sets and hinge members set on both sides of the base seat, first and second side frames hinged at each hinge member, pedal plates respectively slideably mounted on the first and second side frames by wheels under the pedal plates. An end of resistance members is hooked on to crooks under the pedal plates, and the other end is mounted around the pulley sets at the side of the base seat then hooked on to the crooks at fixed end of the first and second side frames. Thereby, a user can step both feet on the pedal plates and move the pedal plates outwardly in horizontal direction to obtain good exercising effect by the resistant force generated from the resistance members while exercising. | 2010-10-14 |
20100261589 | Hamstring Stretching Device - An apparatus that facilitates the stretching and exercising of the hamstring and back muscles is provided. The apparatus can be used for stretching to improve flexibility, to warm up muscles before physical activity, and/or for physical rehabilitation after injury. The apparatus includes a set of hand grips and a set of foot plates. A user grasps the hand grips and positions the arches of his or her feet above the foot plates. The apparatus includes a user actuated drive mechanism for moving a set of hand grips along the shaft toward the foot plates. The user maintains a grip of the hand grips as the hand grips move along the shaft toward the foot plates, thereby stretching the hamstring and back muscles of the user. | 2010-10-14 |
20100261590 | Upper Body Exercise Device - The present invention is a push-up exercise device and a dip exercise device for effectively and efficiently focusing on strengthening an individual's stabilizer muscles. The push-up exercise device may include a handle support connected to a top plate, which is in turn connected to a bottom plate. A hemisphere is removably connected to the bottom plate, and the top plate and the bottom plate may rotate about one another. The push-up exercise device may include a handle support connected to a plate which is connected to a ball. The dip exercise device may be two handle supports connected to a plate connected to multiple legs. The handle supports may rotate and pivot relative to the plate. | 2010-10-14 |
20100261591 | MULTI-DIRECTIONAL BODY SWING, TURN AND TWIST TRAINER WITH INTERCHANGEABLE AND ADJUSTABLE ATTACHMENTS - An exercise apparatus for providing multi-directional training to the body of a user is disclosed. The exercise apparatus allows the user to exercise the mid-section, hips, legs, ankles and connective tissues enjoining all the muscles in these areas. The exercise apparatus comprises a main frame, a foot platform (preferably two) and means for attaching the foot platforms to the main frame. The exercise apparatus is designed to be free standing or to be mounted onto other supporting structures. The apparatus has multiple interchangeable parts, attachments and accessories for allowing several types of exercises. | 2010-10-14 |
20100261592 | Tube Plug - A tube plug is used for a tube wrapped with rollable materials and comprises a support plate, a column, and a positioning part. The column and the positioning part are provided on the same surface of the support plate. Thereby, the length of the wrapped rollable materials can be prevented from increasing when the two openings of the tube are inserted with the tube plug respectively. | 2010-10-14 |
20100261593 | Apparatus and Method for Cutting and Folding Printed Products - A method of folding a printed product is provided. The method includes the steps of cutting a web so as to form a signature having lead edge tabs, the signature having perforation slots and folding the signature so the lead edge tabs enter the perforation slots. Lead edges may be more easily prevented from dislodging and dog-earing and skewing may be minimized. | 2010-10-14 |
20100261594 | RESILIENT TUCKER ELEMENT FOR INTERFOLDER FOLDING ROLLS - A method and apparatus are provided for facilitating folding of material fed through a nip between two folding rolls having a tucker on one roll and a corresponding gripper on the other roll, by using a resilient tucker element having a tip that is moveable from a neutral position thereof, through elastic deformation of at least a portion of a body of the tucker element, for directing a portion of the material into the gripper. The resilient tucker element may have a tucker body formed at least partially of elastically resilient material fixedly attached at a proximal end thereof to the other roll. A portion of a distal end of the resilient tucker element may be wedge-like and have vacuum ports extending at least partially into the wedge-like portion, for securing an end of a sheet of material being fed through the nip between the folding rolls. | 2010-10-14 |
20100261595 | Apparatus for Processing Biological Material - A gripper unit for handling a vessel for receiving biological material is proposed, inter alia. The vessel has a lid which can assume an open position and a closed position. The gripper unit comprises a gripper for gripping and releasing the vessel, and a lid holder, for holding a lid in a defined position in relation to the vessel. The defined position is an open position of the lid. | 2010-10-14 |
20100261596 | APPARATUS AND METHOD FOR TRANSFERRING ENERGY AND/OR A SUBSTANCE TO ROTATING MEANS - The presently disclosed subject matter proposes an apparatus ( | 2010-10-14 |
20100261597 | TIO2-CONTAINING SILICA GLASS - The present invention is to provide a TiO | 2010-10-14 |
20100261598 | OPTICAL GLASS - An optical glass includes, by weight: 1% or more and 5% or less of silicon oxide (SiO | 2010-10-14 |
20100261599 | Taphole Fill Material and Method for Manufacturing the Same - A high-temperature, heat-resistant fill material is disclosed. The high-temperature, heat-resistant fill material includes an alumina refractory waste material having one or more of a used alumina-magnesium-carbon material, a used high-alumina material and a used fused-grain alumina material is disclosed. A method for method for manufacturing a material is also disclosed. | 2010-10-14 |
20100261600 | METAL STRUCTURE, CATALYST-SUPPORTED METAL STRUCTURE, CATALYST-SUPPORTED METAL STRUCTURE MODULE AND PREPARATION METHODS THEREOF - The present invention provides a metal structure for a compact reformer and a preparation method thereof, a catalyst-supported metal structure and a preparation method thereof, and a catalyst-supported metal structure module. More particularly, the present invention relates to a metal structure prepared through electrochemical treatment and heat treatment and a preparation method thereof, a catalyst-supported metal structure prepared by supporting a catalyst on the metal structure and a preparation method thereof, and a catalyst-supported metal structure module manufactured by irregularly layering the catalyst-supported metal structures to improve the contact between reaction gases and catalysts. | 2010-10-14 |
20100261601 | Modified Catalyst Supports - A modified catalyst support exhibiting attrition resistance and/or deaggregation resistance is provided. A catalyst composition including the modified catalyst support is also provided. A process to produce a modified catalyst support including treatment of a support slurry with a solution of monosilicic acid is provided. A process to use a catalyst including the modified catalyst support in a Fischer-Tropsch synthesis is provided. | 2010-10-14 |
20100261602 | METHOD OF PRODUCING NOBLE METAL-SUPPORTED POWDER, NOBLE METAL-SUPPORTED POWDER AND EXHAUST GAS PURIFYING CATALYST - In the present invention, slurry is formed by mixing noble metal-supported powder particles ( | 2010-10-14 |
20100261603 | METHOD FOR THE PRODUCTION OF A SHELL CATALYST LOADED WITH PD AND/OR AU - The present invention relates to a process for the production of a shell catalyst which comprises a catalyst support shaped body with an outer shell in which metallic Pd and/or Au is contained. In order to provide a process by means of which shell catalysts can be obtained, in the outer shell of which relatively high metallic Pd and/or Au contents are contained, a process is proposed comprising the steps of
| 2010-10-14 |
20100261604 | Process for Producing Surface Crosslinked Superabsorbents - Surface-crosslinked superabsorbents are produced using a process that comprises the steps of contacting a superabsorbent base polymer with a polyvalent metal salt solution produced by dissolving at least two different polyvalent metal salts, at least one of which comprises a chelate-forming anion, and heat-treating to produce a surface-crosslinked superabsorbent. | 2010-10-14 |
20100261605 | Method and apparatus for processing work materials - A method and apparatus for processing work materials, the method including the steps of applying substantially into direct contact with the work material a substance operable to promote decomposition of the work material; distributing the work material bearing the substance on a surface disposed for decomposition; and an apparatus for practicing the method having an assembly operable substantially to fragment the work material. | 2010-10-14 |
20100261606 | Homogeneous and Storage-Stable Mixtures of Different Active Plant Protection Agent Granule Particles - The use of mixtures of different plant protectant active substance granule particles which remain homogeneous upon storage, handling and application, for the stable storage of mixing-incompatible active substances, and a preparation process therefor. | 2010-10-14 |
20100261607 | HERBICIDAL GLYPHOSATE COMPOSITION - The present invention relates to exogenous compositions and methods of their use, wherein the exogenous chemicals are applied to one or more surface layers of plants to generate a herbicidal biological response and in particular to a glyphosate-based herbicidal composition for spray application to a plant having superior properties of herbicidal cuticle layer coating and penetration, herbicidal uptake, and herbicidal translocation, without cuticle layer damage. | 2010-10-14 |
20100261608 | Geminal alkoxy/alkylspirocyclic substituted tetramate derivatives - The invention relates to novel compounds of the formula (I) | 2010-10-14 |
20100261609 | Phenoxy Alkanoate Herbicidal Composition and Method of Preparation and Use - This invention relates to a phenoxy alkanoate herbicide composition containing a phenoxyalkanoate amine salt and wherein the amine is a substituted amine and the total amount of substituted amine is at least a 20% molar excess based on the number of moles of phenoxyalkanoate. | 2010-10-14 |
20100261610 | USE OF GLYCEROL, METHOD OF CROP TREATMENT, COMPOSITION FOR TANK MIXING AND A METHOD OF PREPARATION OF A COMPOSITION FOR TANK MIXING - The present invention relates to a method for the treatment of crops, comprising the steps of
| 2010-10-14 |
20100261611 | ASSAY SYSTEM AND METHOD - An array of electro-actuated fluid dispensers ( | 2010-10-14 |
20100261612 | Purification and Concentration of Proteins and DNA from a Complex Sample Using Isotachophoresis and a Device to Perform the Purification - A method of simultaneously co-purifying and concentrating nucleic acid and protein targets into a single volume is described. The method includes automation of the entire sample preparation process, performed by having an analyst add a sample into a device that performs all of the steps necessary to prepare a sample for analysis. The method provides for samples are not split during the sample preparation process and where common purification methods can be used for purifying multiple analytes. | 2010-10-14 |
20100261613 | METHODS FOR INFLAMMATORY DISEASE MANAGEMENT - Quantitative expression datasets are created and used in the identification, monitoring and treatment of disease states and characterization of biological conditions. Quantitative datasets are derived from subject samples and enable evaluation of a biological condition. Such quantitative datasets may be used to provide an output score indicative of the biological state of a subject through analysis against a profile dataset. | 2010-10-14 |
20100261614 | Bacillus thuringiensis Chromosomal Genome Sequences and Uses Thereof - The present invention relates to nucleic acid sequences from | 2010-10-14 |
20100261615 | ATOMIC FORCE MICROSCOPE AS AN ANALYZING TOOL FOR BIOCHIP - The present application discloses a method for detecting a presence of target ligand in a fluid medium which includes the steps of: (i) contacting the fluid medium with a solid substrate that includes an array of dendrons on its surface, wherein each of the dendron includes a central atom, a probe that is attached to the central atom optionally through a linker, and a base portion attached to the central atom and having a plurality of termini that are attached to the surface of the solid support; and (ii) determining the presence of a probe-target ligand complex by measuring binding force between the bound ligand and detection molecule tethered to the tip of an atomic force microscope (“AFM”), which detection molecule has affinity for the ligand, wherein measurement of an increase in force between the probe-target ligand complex and the detection molecule by AFM indicates the presence of the probe-target ligand complex. | 2010-10-14 |
20100261616 | Capturing Sequences Adjacent to type-IIs restriction sites for Genomic Library Mapping - The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the “capturing” and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation. | 2010-10-14 |
20100261617 | GENE EXPRESSION SIGNATURE FOR THE PROGNOSIS, DIAGNOSIS, AND THERAPY OF PROSTATE CANCER AND USES THEREOF - Provided is a method for monitoring the presence and/or progression of prostate tumor in an individual, by measuring the expression level of marker genes out of a novel signature of 39 genes. The invention further discloses a data base and array comprising said identified marker genes for prognosing the tumor progression in an individual suffering from prostate cancer. | 2010-10-14 |
20100261618 | Identification of genes implicated in the virulence of streptococcus agalactiae | 2010-10-14 |
20100261619 | Charge Perturbation Detection System for DNA and Other Molecules - Methods and apparatus for direct detection of chemical reactions are provided. In a preferred embodiment, electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The target molecule is preferably DNA. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal. The initial enzyme attachment to the DNA molecule can be detected prior to polymerization, with electrode capacitance measurement using the same voltage-clamp amplifier. This technique and device may be adapted to other reaction determinations, such as enzymatic reactions, other electrode configurations, and other amplifying circuits. | 2010-10-14 |
20100261620 | Methods of Humanizing and Affinity-Maturing Antibodies - Methods of humanizing and affinity-maturing antibodies are disclosed. | 2010-10-14 |
20100261621 | MICROARRAY SUBSTRATE, METHOD OF USE, AND PRODUCTS COMPRISING THE MICROARRAY SUBSTRATE - Provided are a microarray substrate comprising a solid substrate coated with a chemical having a functional residue represented by Formula 1 or 2 below, a method of analyzing a biomolecule using the microarray substrate, and a lab-on-a-chip comprising the microarray substrate: | 2010-10-14 |
20100261622 | Methods and Compositions for Fracturing Subterranean Formations - Viscoelastic surfactant (VES) gelled aqueous fluids containing water, a VES, an internal breaker, a VES stabilizer, a fluid loss control agent and a viscosity enhancer are useful as treating fluids and particularly as fracturing fluids for subterranean formations. These VES-based fluids have faster and more complete clean-up than polymer-based fracturing fluids. The use of an internal breaker permits ready removal of the unique VES micelle based pseudo-filter cake with several advantages including reducing the typical VES loading and total fluid volume since more VES fluid stays within the fracture, generating a more optimum fracture geometry for enhanced reservoir productivity, and treating reservoirs with permeability above the present VES limit of approximately 400 md to at least 2000 md. | 2010-10-14 |
20100261623 | Corrosion inhibitor compositions comprising an aldehyde and a thiol and/or an amine functionalized ring structure and associated methods - Provided herein are methods and compositions that include a method comprising contacting a metal surface with an acidic fluid comprising a corrosion inhibitor that comprises a reaction product formed from a direct or an indirect reaction of an aldehyde with a thiol and/or an amine functionalized ring structure. A composition provided includes an acidic treatment fluid that comprises an aqueous-base fluid, and acid, and a corrosion inhibitor that comprises a reaction product formed from a direct or an indirect reaction of an aldehyde with a thiol and/or an amine functionalized ring structure. | 2010-10-14 |
20100261624 | Unsaturated Fatty Acids and Mineral Oils As Internal Breakers for VES-Gelled Fluids - Fluids viscosified with viscoelastic surfactants (VESs) may have their viscosities reduced (gels broken) by the direct or indirect action of a synergistic internal breaker composition that contains at least one first internal breaker that may be a mineral oil and a second breaker that may be an unsaturated fatty acid. The internal breakers may initially be dispersed oil droplets in an internal, discontinuous phase of the fluid. This combination of different types of internal breakers break the VES-gelled aqueous fluid faster than if one of the breaker types is used alone in an equivalent total amount. | 2010-10-14 |
20100261625 | COMPOSITION FOR SLIDING MEMBER AND SLIDING MEMBER COATED WITH THE COMPOSITION - An object of the invention is to provide a composition for a sliding member capable of forming a lubricating film which does not occur large cracks in the lubricating film formed even if the formed lubricating film is pressed and slid, large peeling off of the lubricating film is restrained from occurring, and improved in abrasion resistance. The invention provides the composition for the sliding member containing a base resin and nano metal particles softer than the counterpart material of sliding, wherein the content of the soft nano metal particles is 5 vol % or less. | 2010-10-14 |
20100261626 | Universal synthetic lubricant additive with micro lubrication technology to be used with synthetic or miner host lubricants from automotive, trucking, marine, heavy industry to turbines including, gas, jet and steam - It is known by the inventor that a universal synthetic lubricant additive that can greatly enhance the performance standards of existing lubricants, petroleum based or synthetic, imparts a new and desirable property not originally present in the existing oil or it reinforces a desirable property already possessed in some degree can greatly benefit the consumer. Although additives of many diverse types have been developed to meet special lubrication needs, their principal functions are relatively few in number. This universal synthetic lubricant additive (invention) with micro lubrication technology, when used as directed will reduce the oxidative or thermal degradation of the host oil, substantially reduce the deposition of harmful deposits in lubricated parts, minimize rust and corrosion, control frictional properties, reduce wear, temperature, sludge, varnishes and prevent destructive metal-to-metal contact, reduce fuel consumption and harmful emissions while improving performance through increased horsepower and torque. | 2010-10-14 |
20100261627 | DIESTER-BASED LUBRICANTS AND METHODS OF MAKING SAME - The present invention is generally directed to diester-based lubricant compositions. The present invention is also directed to methods of making these and other similar lubricant compositions. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor and/or low value Fischer-Tropsch (FT) olefins and/or alcohols so as to produce high value diester-based lubricants. In some embodiments, such diester-based lubricants are derived from FT olefins and fatty acids. The fatty acids can be from a bio-based source (i.e., biomass, renewable source) or can be derived from FT alcohols via oxidation. | 2010-10-14 |
20100261628 | ESTERS COMPRISING BRANCHED ALKYL GROUPS AS LUBRICANTS - A process for improving the oxidation stability of lubricants including providing one or more esters containing branched alkyl groups which are reaction products of branched alcohols with a) one or more aliphatic dicarboxylic acids corresponding to general formula (II): HOOC—R | 2010-10-14 |
20100261629 | Benefit agent containing delivery particles - The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, compositions for cleaning, fabric care, or coating onto various substrates, textiles or surfaces, such particles increase the efficiency of benefit agent delivery, thereby allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed. | 2010-10-14 |
20100261630 | ANTIMICROBIAL HAND WASH FORMULATIONS - An antimicrobial hand wash comprises an active ingredient and an amphoteric surfactant that is a derivative compound of a fatty amine with a nitrogen atom bound to at least one, but not greater than two, propionic acids. These specific amphoteric surfactants have unexpectedly been found to be compatible with active ingredients such that the antimicrobial efficacy is maintained, while foam quality is improved when the hand wash is dispensed as foam. Other antimicrobial hand washes include polyethylene glycol or polypropylene glycol derivatives that dissolve at least a portion of the active ingredient, thus reducing the amount of solids in the formulation, and making a cold manufacturing process possible. | 2010-10-14 |
20100261631 | BIOFILM-REMOVING AGENT - A biofilm-removing agent which effectively removes biofilms is provided. | 2010-10-14 |
20100261632 | NON-FLUORIDE CONTAINING COMPOSITION FOR THE REMOVAL OF RESIDUE FROM A MICROELECTRONIC DEVICE - Cleaning compositions and processes for removing residue from a microelectronic device having said residue thereon. The composition, which is substantially devoid of fluoride species, amine species, and organic solvents, achieves highly efficacious cleaning of the residue material, including post-etch residue, post-ash residue and/or post-CMP residue, from the microelectronic device while simultaneously not damaging the interlevel dielectric and metal interconnect material also present thereon. | 2010-10-14 |
20100261633 | DETERGENT BUILDER GRANULE - Detergent builder granules containing (component A) a water-soluble inorganic salt containing an inorganic salt having and/or being capable of forming a hydrate crystal and (component B) a clay mineral, wherein the component B is contained in an amount of 60% by weight or less, the component A and the component B are in a weight ratio, i.e. A/B, calculated as an anhydrate, of from 5/95 to 80/20, and a percentage of water loss upon heating to a temperature of 200° C. is from 3 to 30% by weight. According to the present invention, the detergent builder granules for laundry detergents having excellent dispersibility in cold water and a detergent composition containing the detergent builder granules can be obtained. | 2010-10-14 |
20100261634 | AMPHIPHILIC WATER-SOLUBLE ALKOXYLATED POLYALKYLENEIMINES HAVING AN INNER POLYETHYLENE OXIDE BLOCK AND AN OUTER POLYPROPYLENE OXIDE BLOCK - The present invention relates to amphiphilic water-soluble alkoxylated polyalkyleneimines having an inner polyethylene oxide block comprising 20 to 50 polyethylene oxide units and an outer polypropylene oxide block comprising 10 to 50 polyethylene oxide units and especially to such alkoxylated polyalkyleneimines wherein the ratio of polyethylene oxide units and polypropylene oxide units is proportionally related to the square root of the number of polyalkyleneimine units present in the backbone. The present invention further relates to the use of these alkoxylated polyalkyleneimines as a soil detachment promoting additive to laundry detergents and cleaning compositions and to laundry detergents and cleaning compositions which comprise these alkoxylated mono- or polyalkyleneimines. | 2010-10-14 |
20100261635 | Composition comprising a cellulase and a bleach catalyst - The present invention relates to a composition comprising: (i) a bacterial alkaline enzyme exhibiting endo-beta-1,4-glucanase activity (E.C. 3.2.1.4); and (ii) a bleach catalyst that is capable of accepting an oxygen atom from a peroxyacid and transferring the oxygen atom to an oxidizeable substrate. | 2010-10-14 |
20100261636 | STABILIZED HYDROGEN PEROXIDE SOLUTIONS - The present invention is directed to a stabilized hydrogen peroxide solution containing stabilizers that maintain relatively high hydrogen peroxide stability in both concentrated form and when formulated into a cleaning solution that has a pH above 6 and contains components that normally would have a destabilizing effect on the hydrogen peroxide. The stabilizers include a first cyclic amino methane diphosphonic acid compound stabilizer in combination with a second phosphonic acid based stabilizer (different from the cyclic amino methane diphosphonic acid compound), wherein the weight ratio of the first stabilizer to the second stabilizer is at least about 2:1. | 2010-10-14 |
20100261637 | PEPTIDES DERIVATIZED WITH A-B-C-D- AND THEIR THERAPEUTICAL USE - The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogues thereof, as well as therapeutic uses thereof. The peptide derivative of the invention comprises a peptide wherein at least one amino acid residue is derivatized with A-B-C-, or A-B-C-D-. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, have a low ratio of binding affinity to the GLP-1 receptor in the presence of high/low albumin concentrations, have long half-lives, and have a high affinity of binding to albumin, all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration. | 2010-10-14 |
20100261638 | LANTIBIOTIC-BASED COMPOUNDS HAVING ANTIMICROBIAL ACTIVITY - The present invention provides actagardine, actagradine B and deoxy actagardine B derivatives of formula (I), | 2010-10-14 |
20100261639 | TRIAZOLE-BASED AMINOGLYCOSIDE-PEPTIDE CONJUGATES AND METHODS OF USE - Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycoside antibiotic may exhibit antimicrobial activities against Gram-positive and/or Gram-negative strains and display significantly enhanced activity against multi-drug resistant MRSA and MRSE when compared to their unconjugated aminoglycoside antibiotic counterparts. | 2010-10-14 |
20100261640 | SOLUBLE AND MEMBRANE ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS - The invention discloses compositions comprising soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins. This invention further relates to diagnostic and preventative methods using these compositions. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules) that inhibit LASV infectivity. Further, the invention relates to diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses. | 2010-10-14 |
20100261641 | SPIRO-PIPERIDINE COMPOUNDS AND MEDICINAL USE THEREOF - The present invention relates to a spiro-piperidine compound represented by formula (I): | 2010-10-14 |
20100261642 | NUTRITIONAL FORMULATION WITH HIGH ENERGY CONTENT - The present invention concerns high energy formulations for treatment and/or prevention of faltering growth in infants, in particular for promoting catch-up growth in a sick infant. | 2010-10-14 |
20100261643 | PHENOTHIAZINE DERIVATIVE HAVING A DOUBLE BOND, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A PHARMACEUTICAL - The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament. | 2010-10-14 |
20100261644 | (CYCLOPROPYLPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT - The invention relates to (cyclopropylphenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament. | 2010-10-14 |
20100261645 | (CARBOXYLALKYLENEPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF AND USE OF SAME AS A MEDICAMENT - The invention relates to (carboxylalkylenephenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament. | 2010-10-14 |
20100261646 | SUSTAINED INTRAOCULAR DELIVERY OF DRUGS FROM BIODEGRADABLE POLYMERIC MICROPARTICLES - Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents useful for managing elevated intraocular pressure (TOP) in the eye. In one embodiment, the microspheres are formed from polylactide-co-glycolide (“PLGA”); in another embodiment, the microspheres are formed from a blend PLGA and poly lactic acid (“PLA”). Relatively hydrophilic, and preferably carboxylated, polymeric materials such as PLGA are used for a drug such as timolol maleate, which is relatively water soluble, to increase drug loading. Higher molecular weight polymers, as well as the ratio of LA (which has a longer degradation time, up to one to two years) to GA (which has a short degradation time, as short as a few days to a week), are used to provide release over a longer period of time. The combination of drug loading and release rate, as well as the minimization of initial burst release, result in prolonged release of a higher amount of drug. | 2010-10-14 |
20100261647 | FUSION PROTEINS FOR DELIVERY OF ERYTHROPOIETIN TO THE CNS - The invention provides compositions, methods, and kits for increasing transport of a neurotrophin (e.g., erythropoietin (EPO)) across the blood brain barrier while allowing its activity to remain substantially intact. The neurotrophin (e.g., EPO) is transported across the blood brain barrier via one or more endogenous receptor-mediated transport systems. | 2010-10-14 |
20100261648 | USE OF BLOOD FLOW PARAMETERS TO MONITOR OR CONTROL THE DOSING OF ERYTHROPOIESIS-STIMULATING AGENTS - A method that includes a measurement of hemoglobin or hematocrit with a measurement of hemodynamic parameters to monitor and/or control a modality of treatment of a patient suffering from anemia. | 2010-10-14 |
20100261649 | LH LIQUID FORMULATIONS - The invention relates to liquid pharmaceutical formulations of luteinizing hormone (LH) for single- or multi-dose administration. | 2010-10-14 |
20100261650 | RECOMBINANT FUSION PROTEINS TO GROWTH HORMONE AND SERUM ALBUMIN - The invention describes albumin fusion proteins comprising growth hormone and serum albumin. The invention also describes nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acid molecules, host cells transformed with these vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally, the invention describes compositions comprising the albumin fusion proteins, and methods of treating patients in need of growth hormone, comprising administering the albumin fusion proteins of the invention. | 2010-10-14 |
20100261651 | Purification and Use of a Factor for Supporting Wound Healing - A process for manufacturing of a composition containing a purified factor for supporting wound healing selected from the group consisting of Hepatocyte Growth Factor (HGF) platelet derived growth factor (PDGF), Epidermal growth factor (EGF), transforming growth factor alfa (TGF-α), Transforming growth factor beta (TGF-β), insulin like growth factor (IGF-1) and Fibroblast growth factor (FGF) from sources, such as blood, containing the factor for supporting wound healing, wherein the manufacturing process comprises purification steps which are performed in the presence of antithrombin III (AT-III). | 2010-10-14 |
20100261652 | Tissue Adhesive Using Engineered Proteins - There is provided in one embodiment of the disclosure a tissue adhesive composition comprising an engineered protein having repeated blocks of an elastin domain and at least one cell-binding domain and further comprising a polymer crosslinker. When the engineered protein and the polymer crosslinker are introduced onto a tissue, the engineered protein and the polymer crosslinker initiate an in situ crosslinking reaction to form an adhesive bond that is mechanically strong, transparent, biocompatible, and stimulates regrowth of one or more tissue layers over the adhesive bond. In another embodiment of the disclosure there is provided a molded corneal onlay and method of making the same. | 2010-10-14 |
20100261653 | Polypeptide compounds for inhibiting angiogenesis and tumor growth - In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases. | 2010-10-14 |
20100261654 | COMPOSITIONS AND METHODS FOR INCREASING VASCULARIZATION - Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject. | 2010-10-14 |
20100261655 | VIRAL CAPSID PROTEINS AND ANY PEPTIDES OR COMPOSITIONS THEREOF FOR THE TREATMENT OF PATHOLOGIC DISORDERS - The present invention relates to viral capsid proteins, as a medicament for the treatment of a pathologic disorder. More particularly, the invention relates to the viral capsid proteins VP1, VP2 and VP3, preferably, the SV40 VP1 or any peptide, fragment, mutant, derivative and mixtures thereof or of virus-like particles (VLP's) comprising the same, as the active ingredient in compositions for the treatment of pathologic disorders, preferably disorders associated with inactivation of cellular proteins involved with quality control processes, particularly, chaperones. The invention further provides methods for the treatment of such disorders and the use of the SV40 capsid proteins for the preparation of pharmaceutical compositions. | 2010-10-14 |
20100261656 | Therapeutic Use of the Encoding Sequence of the Carboxy-Terminal Domain of the Heavy Chain of the Tetanus Toxin - The present invention relates to the therapeutic use of the encoding sequence of the carboxy-terminal domain of the heavy chain of the tetanus toxin and of the polypeptide encoded by said sequence, preferably for the treatment of amyotrophic lateral sclerosis (ALS). | 2010-10-14 |
20100261657 | Use of a Granulin or a Granulin-Like Compound in the Therapy or Prophylaxis of Chronic Pains - The invention relates to the use of a granulin or a granulin-like compound for producing a pharmaceutical composition for the therapy or prophylaxis of chronic pain, in particular for neuropathic pain. | 2010-10-14 |
20100261658 | PEPTIDE FOR ACTIVATING AQUAPORIN SYNTHESIS - The present invention concerns a peptide of the general formula (I):
| 2010-10-14 |
20100261659 | SECRETED FRIZZLED RELATED PROTEIN 3 FOR USE IN THE INHIBITION OF SCARRING - Provided is secreted Frizzled Related Protein 3 (sFRP3), or a therapeutically effective fragment or derivative thereof, for use as a medicament for the prevention, reduction or inhibition of scarring. The scarring may be associated with the healing of a wound, or with a fibrotic disorder. The scarring may be associated with surgical wounds. The scarring may be scarring of the skin. The medicament may be a topical medicament, and may be suitable for local injection. Also provided is a method of preventing, reducing or inhibiting scarring, the method comprising administering a therapeutically effective amount of sFRP3, or a therapeutically effective fragment or derivative thereof, to a patient in need of such prevention, reduction or inhibition. | 2010-10-14 |
20100261660 | Novel co-stimulatory molecules - The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines. | 2010-10-14 |
20100261661 | COMPOSITIONS AND METHODS FOR INCREASING THE SUPPRESSION OF HUNGER AND REDUCING THE DIGESTIBILITY OF NON-FAT ENERGY SATIETY - The present invention relates to methods for increasing the suppression of hunger and/or increasing the reduction of prospective consumption and/or increasing the reduction of appetite and/or increasing the feeling of satiety and/or reducing non-fat energy uptake in the gastrointestinal tract of a mammal in order to prevent a positive non-fat energy balance, weight gain, over-weight and obesity, and to induce a negative non-fat energy balance and weight loss in subjects who wish to reduce their body weight. In particular, feed, food and/or beverages and dietary supplements of the present invention comprises mucilage such as flax seed mucilage and/or one or more active compounds of mucilage useful for increasing the suppression of hunger and/or increasing the reduction of prospective consumption and/or increasing the reduction of appetite and/or increasing the feeling of satiety and/or reducing the digestibility of non-fat energy in the gastrointestinal tract of a mammal. | 2010-10-14 |