41st week of 2012 patent applcation highlights part 41 |
Patent application number | Title | Published |
20120259096 | ANTIBODIES TO ION CHANNELS - An anti-E1 ion channel antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies. | 2012-10-11 |
20120259097 | USE OF ANTI-FACTOR XI ANTIBODIES FOR PREVENTION OF THROMBUS FORMATION - The present invention relates to binding molecules such as antibodies that specifically bind plasma coagulation factor XI and that inhibit factor XI activation and/or activity. The factor XI-binding molecules of the invention may used in methods for preventing or treating diseases, disorders and/or conditions that are mediated by factor XI activation and/or wherein inhibition of factor XI has a beneficial effect. | 2012-10-11 |
20120259098 | DENDRIMER COMPOSITIONS AND METHODS OF SYNTHESIS - The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))). | 2012-10-11 |
20120259099 | METHOD FOR MANUFACTURING DIMERS AND MULTIMERS BY INCREASING THE PRODUCTION OF BOND BRIDGES IN A COMPLEX OF MULTIPLE MONOMERS AND REPEATING CHAINS OF AN ADHEREND OF A TYPE SPECIFICALLY ADHERING TO MONOMERS - The present invention relates to a method for manufacturing multimers by making repeat chains comprising repeatedly linked affinity domains binding specifically to monomers, and by using the same to create a repeat chain/multiple-monomer complex created from the repeat chains and multiple number of monomers, thereby facilitating the formation of bond bridges between the monomers in the complex to produce inter-monomeric bond bridged multimer. | 2012-10-11 |
20120259100 | PROCESS FOR MANUFACTURING CONJUGATES OF IMPROVED HOMOGENEITY - The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved homogeneity comprising performing the modification reaction at a lower temperature. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent at a temperature of about 15° C. or less to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto. | 2012-10-11 |
20120259101 | Isopeptide Bond Formation in Bacillus Species and Uses Thereof - A mechanism for a unique isopeptide bond formation between polypeptides is disclosed as well as sequence motifs used in such bond formation and methods of using such sequence motifs. | 2012-10-11 |
20120259102 | 18F-Labeled Monomeric Galactose Derivative Used as Tomography Probe | 2012-10-11 |
20120259103 | GRANULATED MALTITOL FOR DIRECT COMPRESSION AND METHOD OF PREPARATION THEREOF - Method of producing granulated maltitol, including the stages: | 2012-10-11 |
20120259104 | SELF-AMPLIFYING FOLDED OLIGONUCLEOTIDE STRUCTURE - The present invention relates to a self-amplifying folded oligonucleotide structure for sensitive oligonucleotide sensing without polymerase chain reaction (PCR). A self-amplifying folded oligonucleotide structure comprise a target sensing sequence having stem loop structure, a signaling molecule and signal modifying molecule labeled two stems wherein the two stems include oligonucleotide sequence that is complementary to a target sensing sequence of another self-amplifying folded oligonucleotide structure. | 2012-10-11 |
20120259105 | HUMAN PAPILLOMA VIRUS PROBES FOR THE DIAGNOSIS OF CANCER - In one embodiment, the invention relates to a method of detecting cervical cancer, and other types of cancer, using a combination of at least three genomic clones, or fragments thereof, of high risk Human Papilloma Virus. For example, the invention relates to a composition comprising at least three full length genomic clones, or fragments thereof, of high risk Human Papilloma Viruses. | 2012-10-11 |
20120259106 | ASYNTHESIS OF B-NUCLEOSIDES - A process of stereoselectively synthesizing β-nucleoside, e.g., 2′-deoxy-2,2′-difluorocytidine, is described. The process includes reacting a tetrahydrofuran compound of the following formula: | 2012-10-11 |
20120259107 | Coupling Low-Molecular Substances To A Modified Polysaccharide - The invention relates to a method for coupling low-molecular substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body. | 2012-10-11 |
20120259108 | COMPOSITION COMPRISING AN ALPHA-CYCLODEXTRIN-CHLORINE DIOXIDE COMPLEX AND AN INERT SUBSTANCE, AND ALSO METHOD FOR PRODUCTION THEREOF - The invention relates to a safely handleable and transportable composition including an alpha-cyclodextrin-chlorine dioxide complex and an inert substance, and also a method for production thereof. | 2012-10-11 |
20120259109 | Guar Gum Containing Compounds - Disclosed is a method of reducing the appearance of coloring streaks in a composition that has a colorant comprising adding a guar gum containing compound to said composition. | 2012-10-11 |
20120259110 | PHARMACEUTICAL SUBSTANCES ON THE BASIS OF MITOCHONDRIA-ADDRESSED ANTIOXIDANTS - This invention relates to the fields of pharmaceutics and medicine, and, in particular, relates to the production and use of pharmaceutical substances on the basis of mitochondria-addressed compounds. The invention discloses methods for synthesis, purification and storage of mitochondria-addressed antioxidants, making it possible to produce said substances in a form and quality meeting the demands made on active ingredients of medicinal preparations—the pharmaceutical substances. The invention also discloses methods for design and selection of new mitochondria-addressed antioxidants having specified properties. | 2012-10-11 |
20120259111 | SEVEN-MEMBERED RING COMPOUND AND PHARMACEUTICAL USE THEREFOR - A compound having a 7-membered nitrogen-containing ring skeleton represented by the formula (I), which is useful for the prevention or treatment of diseases, in which chymase is involved | 2012-10-11 |
20120259112 | METHODS FOR THE SYNTHESIS OF POLYCYCLIC GUANIDINE COMPOUNDS - The present invention provides methods for the synthesis of polycyclic guanidine compounds. In certain embodiments, provided methods include the step of contacting a described reagent with a triamine compound to provide a polycyclic guanidine compound. | 2012-10-11 |
20120259113 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS - In one aspect, the invention relates to compounds having the formula: | 2012-10-11 |
20120259114 | MULTIFUNCTIONAL SMALL MOLECULES - The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same. | 2012-10-11 |
20120259115 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES: THEIR INTERMEDIATES AND SYNTHESIS - This invention relates to methods and intermediates useful for the synthesis of pyrrolo [2,3-d] pyrimidine compounds. Specifically novel synthetic methods and intermediates for the synthesis of 3-{(3R,4R)-4-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino}-piperidin-1-yl)-3-oxo-propionitrile and its corresponding citrate salt are disclosed. | 2012-10-11 |
20120259116 | Novel Process for the Preparation of Paliperidone - The present invention relates to a novel process for the preparation of paliperidone by hydrolysis of | 2012-10-11 |
20120259117 | ORGANO-METALLIC FRAMEWORKS AND METHODS OF MAKING SAME - The disclosure provides organic frameworks comprising increased stability. | 2012-10-11 |
20120259118 | LOW ABUK OXYCODONE, ITS SALTS AND METHODS OF MAKING SAME - A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone. | 2012-10-11 |
20120259119 | ISATIN DERIVATIVES, MEDICAMENTS CONTAINING THE ISATIN DERIVATIVES AND METHOD FOR ITS PREPARATION - The present invention relates to an isatin derivative having the formula (I), a medicament for treatment of tuberculoses containing that isatin derivative as well as a method for preparing isatin derivative according to formula (I). | 2012-10-11 |
20120259120 | DIAZONIUM-FREE METHOD TO MAKE AN INDAZOLE INTERMEDIATE IN THE SYNTHESIS OF BICYCLIC 5-(TRIFLUORMETHOXY)-1H-3-INDAZOLECARBOXYLIC ACID AMIDES - The present invention provides novel methods for preparing 5-(trifluoromethoxy)-1H-3-indazolecarboxylic acid (3), which is a useful precursor for the preparation of bicyclic-5-trifluoromethoxy-1H-indazole-3-carboxylic acid amides of Formula (1). Compounds of Formula (1) are active as agonists and partial agonists of the nicotinic α-7 receptor and are being studied for their use in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders. The present methods are useful for preparing compound (3) on scale up levels. | 2012-10-11 |
20120259121 | PROCESS FOR THE PREPARATION OF MONTELUKAST AND SALTS THEREOF - The present invention relates to an improved process for the preparation of Montelukast and pharmaceutical acceptable salts or derivatives thereof, in particular to a process for large scale production of Montelukast and salts thereof in high yield and high purity and pharmaceutical preparations containing said compounds. | 2012-10-11 |
20120259122 | BENZYLPIPERIZINE COMPOUND - Disclosed is a benzylpiperizine compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which is useful as a medicinal agent such as an antidepressant agent. (In the formula (1), R | 2012-10-11 |
20120259123 | AMINOPYRIDINE COMPOUND - The present invention relates to a compound represented by the formula (I): | 2012-10-11 |
20120259124 | COMPOSITION, SYNTHESIS AND USE OF ISONITRILES - The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulfinyl methyl isonitriles to prepare various other isonitrile compounds and derivatives thereof. In yet another aspect, the present invention includes a relatively simple and routine synthesis of sulfinyl methyl isonitrile compounds, other isonitrile compounds and derivatives thereof. | 2012-10-11 |
20120259125 | PROCESSES FOR PRODUCING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE - The present invention provides processes for producing 2-chloro-3-trifluoromethylpyridine which is useful as an intermediate for medicines and agrochemicals, at a high production rate in a high yield. Specifically, the present invention relates to a process for producing 2-chloro-3-trifluoromethylpyridine or a salt thereof comprising allowing 3-trifluoromethylpyridine N-oxide to react with a chlorinating agent; and also relates to a process for producing 2-chloro-3-trifluoromethylpyridine or a salt thereof comprising oxidizing 3-trifluoromethylpyridine to produce 3-trifluoromethylpyridine N-oxide and subsequently allowing the obtained 3-trifluoromethylpyridine N-oxide to react with a chlorinating agent. | 2012-10-11 |
20120259126 | LIPOPHILIC METALLATES - The present invention relates to arylated, silylated and/or alkylated bis(2,2′-diphenolato)metallates and to a method for the production thereof. | 2012-10-11 |
20120259127 | PROCESS FOR THE RESOLUTION OF ENANTIOMERS BY PREFERENTIAL EVAPORATIVE CRYSTALLIZATION - A process for the resolution of two enantiomers which involves inducing the preferential crystallization of one enantiomer by adjusting the composition of a suspension or solution including a racemic mixture of the two enantiomers and a solvent, by evaporation of the latter. | 2012-10-11 |
20120259128 | ADAMANTANAMINE DERIVATIVE - Disclosed is an adamantanamine derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor. | 2012-10-11 |
20120259129 | Process for Preparing Azabicyclic Compounds - The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof. | 2012-10-11 |
20120259130 | PROCESS FOR SYNTHESIZING PHOSPHONIC AND PHOSPHINIC ACID COMPOUNDS - The present invention is directed to an improved process for synthesizing phosphonic and phosphinic acid chymase inhibitor compounds. | 2012-10-11 |
20120259131 | PHTHALIC ANHYDRIDE PROCESS - Disclosed is an improved process for the production of phthalic anhydride wherein the spent catalyst is removed from the oxidation reactor tubes more effectively by vacuuming from the top and using a vacuum hose having a tip with an increased impact strength and with a maximum hardness. As a result, the new catalyst loading can be made more uniform and the process may be operated with improved stability at higher organics loadings in the reactor feed. Process stability may be further improved by varying the outlet temperature of the phthalic anhydride precondenser over time. | 2012-10-11 |
20120259132 | PROCESS TO PREPARE AN ETHANOL-DERIVATE - The invention is directed to a process to prepare an ethanol-derivate compound or compounds by reacting ethanol in the presence of molecular oxygen and a catalyst comprising a gamma-alumina carrier, metal nano-particles wherein the metal is selected from silver, copper or gold. The invention is also directed to processes to prepare such a catalyst. | 2012-10-11 |
20120259133 | OIL OR FAT COMPOSITION - Provided is an oil or fat composition, which has an MCPD-FS content (ppm) of 13 ppm or less, the content being measured by a Deutsche Gesellschaft für Fettwissenschaft (DGF) standard method C-III 18(09), has a diacylglycerol content of 15 mass % or more, and is subjected to deodorization treatment. | 2012-10-11 |
20120259134 | PROCESS FOR PRODUCTION OF ZINC TOLUENESULFONATE, ZINC TOLUENESULFONATE, AND PROCESS FOR PRODUCTION OF CARBAMATE - A process for producing zinc toluenesulfonate comprising reacting a zinc compound comprising Zn(OH) | 2012-10-11 |
20120259135 | COMPLEX MIXED LIGAND OPEN FRAMEWORK MATERIALS - The disclosure provides multivariate metal organic frameworks comprising different functional ligands. | 2012-10-11 |
20120259136 | METHOD FOR COOLING LIQUID - In a method for cooling liquid, when a liquid containing a volatile component and a surfactant is supplied to an atmosphere having a pressure which is lower than or equal to the saturated vapor pressure of the volatile component so that at least a portion of the volatile component is vaporized, whereby the liquid is cooled, a gas other than the volatile component is introduced into the atmosphere having the pressure so that the gas contacts the liquid. | 2012-10-11 |
20120259137 | COMPOSITION, SYNTHESIS, AND USE OF ISONITRILES - The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulfinyl methyl isonitriles to prepare various other isonitrile compounds and derivatives thereof. In yet another aspect, the present invention includes a relatively simple and routine synthesis of sulfinyl methyl isonitrile compounds, other isonitrile compounds and derivatives thereof. | 2012-10-11 |
20120259138 | METHODS AND SYSTEMS OF PRODUCING DICARBOXYLIC ACIDS - A method of producing succinic acid (SA) includes providing fermentation derived diammonium succinate (DAS) containing solution, converting the DAS containing solution to a solution containing a half-acid, half-salt of succinic acid (MXS) by reactive evaporation, crystallizing MXS from the MXS containing solution by cooling and/or evaporative crystallization, converting MXS to SA by biopolar membrane electrodialysis, anion exchange, cation exchange, or a combination thereof, and crystallizing SA from SA the containing solution generated during conversion of the MXS to SA by cooling and/or evaporative crystallization. | 2012-10-11 |
20120259139 | METHOD FOR PREPARING HIGHER ETHANOLAMINES - The present invention relates to a process for preparing ethanolamines by reacting glycolaldehyde with monoethanolamine and/or diethanolamine in the presence of a catalyst. | 2012-10-11 |
20120259140 | CURING ACTIVATORS - Use of compounds of molecular formula (I) as curing activators of mixes having a cross-linkable unsaturated-chain polymer base: ([R | 2012-10-11 |
20120259141 | Process for the Production of an Acylation Catalyst - The present invention relates to a process for the preparation of a zeolitic material having a BEA framework structure comprising the steps of: (i) providing one or more zeolitic materials having a BEA framework structure, wherein the BEA framework structure comprises YO | 2012-10-11 |
20120259142 | Controlling the Normal:ISO Aldehyde Ratio in a Mixed Ligand Hydroformylation Process - A method of controlling an in-series, multiple, e.g., two, reaction zone, hydroformylation process for producing normal (N) and iso (I) aldehydes at a N:I ratio, the process comprising contacting an olefinically unsaturated compound with synthesis gas and a catalyst comprising (A) a transition metal, e.g., rhodium, (B) an organobisphosphite ligand, and (C) an organomonophosphite ligand, the contacting conducted in first and subsequent reaction zone(s) and at hydroformylation conditions comprising a transition metal concentration in each zone, the method comprising decreasing the transition metal concentration in the first reaction zone to decrease the N:I ratio or increasing the transition metal concentration in the first reaction zone to increase the N:I ratio. | 2012-10-11 |
20120259143 | FLUOROALKYLALKOXYLATES - Disclosed is a fluorinated alkylalkoxylate compound of Formula 1, | 2012-10-11 |
20120259144 | MANUFACTURE OF METHANOL - An alcohol such as methanol is produced from an alkane such as methane and oxygen in a single step process using a heterogeneous catalyst. The catalyst comprises the chloride salts of copper, potassium, lead and zinc. | 2012-10-11 |
20120259145 | MANUFACTURE OF METHANOL - Methanol is produced from methane and oxygen in a single step process using a heterogeneous catalyst. The catalyst comprises the chloride salts of copper, potassium, lead and zinc. | 2012-10-11 |
20120259146 | RENEWABLE COMPOSITIONS - The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions. | 2012-10-11 |
20120259147 | Hydrocarbon cracking furnace with steam addition to lower mono-nitrogen oxide emissions - An apparatus and method is presented for reducing mono nitrogen oxide emissions in a hydrocarbon processing furnace. A preferred embodiment hydrocarbon cracking furnace includes a firebox with a set of wall burners and a set of floor burners, the floor burners comprising secondary burner tips burning a fuel-rich mixture and positioned below primary burner tips burning a fuel-lean mixture. A portion of flue gases are recirculated from the primary burner combustion area to the secondary burner combustion area and back to the primary burner combustion area. The floor burners further comprise a set of steam injection ports that inject steam into a conical flow to contact flames at the primary burner tips, reducing flame temperature and thereby reducing thermal NOx. The steam injection ports are positioned in the firebox above the primary burner tips. | 2012-10-11 |
20120259148 | Process For The Alkylation Of Organic Compounds - The present invention relates to a process for the alkylation of an organic compound comprising: (a) providing a catalyst comprising one or more zeolitic materials having a BEA framework structure, wherein the BEA framework structure comprises YO | 2012-10-11 |
20120259149 | METHOD AND APPARATUS TO DEMILITARIZE MUNITION ENERGETICS - A method of demilitarizing an energetic is disclosed. The method comprises indirectly heating the energetic in a chamber to a temperature below a combustion temperature of the energetic to at least partially decompose the energetic and substantially preclude combustion of the energetic such that the indirect heating produces a decomposition gas, and separating at least a portion of the decomposition gas from the chamber. The method may further comprise monitoring the decomposition gas and/or passing the separated decomposition gas through an air abatement system. The method may further comprise adjusting at least one of the following: the indirect heating of the energetic, the separating of the decomposition gas, the air abatement system, and a residence time of the energetic in the chamber. The energetic may be a bulk energetic. | 2012-10-11 |
20120259150 | Compositions and Methods of Sphingosine Kinase Inhibitors In Radiation Therapy of Various Cancers - The present invention relates to Sphingosine kinase inhibitors that are useful for treating various cancers. The invention further relates to compositions and methods of SPK inhibitors, including siRNAs, which specifically block gene expression of SPK and potentiates the effect of radiation in the treatment of various cancers. | 2012-10-11 |
20120259151 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE - The present invention provides new pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans. | 2012-10-11 |
20120259152 | TREATMENT OF HYPOXIC TUMORS WITH LOCALIZED OXYGENATION - Methods and systems for treatment of hypoxic tumors are provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering an oxygenating agent to the tumor tissue via the delivery device and radiating the tumor tissue with radiation. Methods and systems of treatment of tumors are also provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering a photosensitizing agent to the tumor tissue via the delivery device, and radiating the tumor tissue with light. | 2012-10-11 |
20120259153 | DELIVERY SYSTEMS FOR BRACHYTHERAPY, AND ASSOCIATED METHODS - Delivery systems adapted for implementation during a brachytherapy procedure are provided. The delivery system includes a plurality of brachytherapy seeds and a plurality of spacers. Each spacer is formed of a matrix material carrying a plurality of microparticles and/or nanoparticles. The microparticles and/or nanoparticles carry an agent and are biodegradable and/or biocompatible. The brachytherapy seeds and the spacers are configured to be delivered to a target site. Associated methods are also provided. | 2012-10-11 |
20120259154 | In Vivo Immunomagnetic Hyperthermia Platform for Any Cell or Virus Having a Target Surface Receptor - The invention is a nano-entity conjugate for use in an in vivo immunomagnetic hyperthermia system for the detection and treatment of any cell or virus having a target surface receptor which encompasses a technology platform that can be used for both real-time monitoring of any cell or virus having a target surface receptor and as a delivery platform for certain types of treatment that are conducive for in vivo applications. The system allows of cell or virus enumeration; cell or virus capture; and cell or virus removal from the patient's circulatory system in-vivo using immunomagnetic hyperthermia. The application of immunomagnetic hyperthermia may actually diminish and eventually stop the progression of cancer and other blood borne or blood affected diseases. | 2012-10-11 |
20120259155 | MAGNETIC BODY AND DRUG DELIVERY CONTROL DEVICE USING MAGNETIC BODY - A magnetic body may be suitably applied to a drug delivery system using magnetism. Furthermore, a drug delivery control device allows the magnetic body to be suitably applied to drug delivery. The magnetic body includes a magnet and a cover part attached to an edge of the magnet. The cover part is composed of a material with high magnetic permeability, and a ratio of a length to a radius of the cover part is 10:1 to 7:3. The drug delivery control device includes the magnetic body, a head for supporting the magnetic body and a drive mechanism of the head that causes the head to operate along a projected region formed by the affected area with respect to a surface of a tissue. A magnetic field is applied from the magnetic body to the affected area where a magnetic drug is administered. | 2012-10-11 |
20120259156 | Coordinated Resuscitation Perfusion Support - This document relates to systems and techniques for the treatment of a cardiac arrest victim via electromagnetic stimulation of physiologic tissue. | 2012-10-11 |
20120259157 | Cannula Systems and Methods - Disclosed herein is a cannula assembly for directing the flow of material from an organ chamber, e.g., blood from the left chamber of the heart, and methods of placing the cannula assembly in fluidic communication with the chamber. The cannula assembly includes an elongate tubular member and a coupling assembly disposed at the distal end of elongate tubular member. The elongate tubular member includes a lumen extending from a distal opening at the distal end to a proximal opening at the proximal end. The coupling assembly includes a retaining element and a retention member configured to cooperate with each other and with the portion of the organ wall surrounding the opening in the wall to couple or anchor cannula system to the wall and to provide fluidic communication between the distal opening of the elongate tubular member and the organ chamber. | 2012-10-11 |
20120259158 | METHODS AND APPARATUS FOR TRANSMITTING VIBRATIONS - Methods and apparatus for transmitting vibrations via an electronic and/or transducer assembly through a dental patch are disclosed herein. The patch assembly may be attached, adhered, or otherwise embedded intra-orally on a tooth or oral tissue. The electronic and transducer assembly may receive incoming sounds either directly or through a receiver to process and amplify the signals and transmit the processed sounds via a vibrating transducer element coupled to a tooth or other bone structure, such as the maxillary, mandibular, or palatine bone structure. | 2012-10-11 |
20120259159 | PESSARY DEVICE - A non-expandable pessary device, the pessary device having a top, a base, a length, a longitudinal axis, a maximum diameter, and a minimum diameter that is less than the maximum diameter. The pessary device has a pressure region adapted to extend between an anterior vaginal wall and a posterior vaginal wall of a user to provide pressure on the user's urethra through the vaginal wall. The pressure region includes the maximum diameter, and the maximum diameter is less than 25 mm. | 2012-10-11 |
20120259160 | PESSARY DEVICE HAVING IMPROVED COMFORT - A non-expandable intravaginal pessary device. The device has a top and a bottom, and a sidewall that extends between the top and the bottom. The sidewall, top and bottom form an outer periphery defining a total area of the device. The device has an interior that is substantially enclosed by the top, the bottom, and the sidewall. The sidewall has a convex bottom portion, a mid-section, and a convex top portion. The convex bottom portion connects the bottom to the mid-section, and the convex upper portion connects the top to the mid-section. The convex bottom portion has a maximum diameter of less than about 25 mm, and the mid-section has a maximum diameter less than the maximum diameter of the convex bottom portion. | 2012-10-11 |
20120259161 | PESSARY DEVICE WITH LONGITUDINAL FLEXIBILITY - An intravaginal pessary device. The device has a top, a mid-section, and a bottom. The device has a sidewall that extends between the top and the bottom, and the top, the bottom, and the sidewall form an outer periphery defining a total area of the device. The top has a first width and the mid-section has a second width, and the first width is greater than the second width. In addition, the top has a first flexibility and the mid-section has a second flexibility, and the first flexibility is greater than the second flexibility. | 2012-10-11 |
20120259162 | PESSARY DEVICE WITH IMPROVED PRESSURE PROFILE - A non-expandable intravaginal pessary device capable of providing varying pressure along the length of a woman's urethra when inserted into the woman's vagina. The device has a top, a bottom, and a sidewall that extends between the top and the bottom, and the sidewall, top and bottom form an enclosed outer periphery defining a total area of the device. The sidewall has a convex bottom portion, a mid-section, and a convex top portion. The convex bottom portion connects the bottom to the mid-section, the convex upper portion connects the top to the mid-section, and the convex bottom portion and the convex upper portion are capable of providing pressure to two distinct locations on a woman's urethra when inserted into a woman's vagina. | 2012-10-11 |
20120259164 | PESSARY DEVICE - A non-expandable intravaginal pessary device. The device has a top, a bottom, and a sidewall that extends between the top and the bottom. The top, bottom, and sidewall form an outer periphery defining a total enclosed area of the device. The device has a first region adapted to extend between an anterior vaginal wall and a posterior vaginal wall of a woman to provide pressure on the woman's urethra through the vaginal wall, the first region having a first width and a second region having a second width, wherein the first width is greater than the second width. In addition, the device applies a first pressure to a first portion of the urethra when inserted into the woman's vagina and applies a second pressure to a second portion of the urethra, wherein the second pressure is less than the first pressure. | 2012-10-11 |
20120259165 | LOBED PESSARY DEVICE - An intravaginal pessary device is provided. The device has a top, a bottom, a sidewall that extends between the top and bottom, and a length. The sidewall has a lower lobe, a mid-section, and an upper lobe. The lower lobe connects the bottom to the mid-section, the upper lobe connects the top to the mid-section, and the sidewall has curvilinear transitions from the upper lobe to the mid-section and from the mid-section to the lower lobe. | 2012-10-11 |
20120259166 | ARRAY OF PESSARY DEVICES - An array of non-expandable pessary devices. The array includes a first pessary device having a top, a base, a length, a sidewall extending between the top and the base, a longitudinal axis, a maximum diameter, and a minimum diameter that is less than the maximum diameter. The first pessary device has a pressure region adapted to extend between an anterior vaginal wall and a posterior vaginal wall of a user to provide pressure on the user's urethra through the vaginal wall, the pressure region comprising the maximum diameter, wherein the maximum diameter is less than 25 mm. The array also includes a second pessary device having a top, a base, a length, a sidewall extending between the top and the base, a longitudinal axis, a maximum diameter, and a minimum diameter that is less than the maximum diameter. The second pessary device has a pressure region adapted to extend between an anterior vaginal wall and a posterior vaginal wall of a user to provide pressure on the user's urethra through the vaginal wall, the pressure region comprising the maximum diameter, wherein the maximum diameter is less than 25 mm. The maximum diameter of the second pessary device can be greater than the maximum diameter of the first pessary device. | 2012-10-11 |
20120259167 | SINGLE USE PESSARY DEVICES - A non-expandable single use pessary device. The pessary device has a top, a base, a length, an outer surface, a longitudinal axis, a maximum diameter, and a minimum diameter that is less than the maximum diameter. The pessary device includes a pressure region adapted to extend between an anterior vaginal wall and a posterior vaginal wall of a user to provide pressure on the user's urethra through the vaginal wall. The pressure region includes the maximum diameter. In addition, the outer surface includes a usage indicator that is visible to a user viewing the outer surface of the device after the device is removed from the user's vagina. | 2012-10-11 |
20120259169 | IMPLANTABLE SLING FOR THE TREATMENT OF INCONTINENCE AND METHOD OF USING THE SAME - A method of treating incontinence in a male patient includes forming a non-scrotal incision in the male patient; traversing an anchor portion of an implant through the incision and through an obturator foramen of the male patient; securing the anchor portion of the implant to a ramus of the male patient; and placing a support portion of the implant in the incision to support a urethra of the male patient. | 2012-10-11 |
20120259170 | METHOD FOR MAKING A FLEXIBLE STENT-GRAFT - A method of making a stent-graft is provided. The method includes mounting a stent on a mandrel so that the stent is stretched when it is on the mandrel. A graft layer is then adhered to the stent while it is mounted on the mandrel. When the stent-graft is removed from the mandrel, the stent contracts and the graft layer becomes partially wrinkled when the stent is in its expanded relaxed state. | 2012-10-11 |
20120259172 | Instrument Adaptor for Image Guided Surgery - The invention relates to an adaptor for tracking an instrument location during image guided surgery. The adaptor has a drive shaft, a proximal handle and a distal instrument tip. The drive shaft has a linear proximal portion, a curved mid-portion and a linear distal portion that is co-linear with the linear proximal portion. Three tracking elements (such as reflective balls) are placed on the sinusoidal portion. When the handle is rotated, the two linear portions remain fixed on the longitudinal axis, but the tracking elements on the sinusoidal portion travel in orbits about the longitudinal axis, thereby allowing a computer to track the location of the instrument tip. | 2012-10-11 |
20120259173 | VISUALIZATION DEVICE AND HOLDER FOR USE WITH A TRACHEAL TUBE - The present disclosure describes systems and methods that utilize a tracheal tube with an integral visualization device, such as a camera. The tracheal tube system may include a camera apparatus or other visualization device that is associated with a lumen formed in the wall of the tube. In addition, the camera apparatus may be positioned within a holder associated with a distal end of the tracheal tube that functions to hold and position the optical components of the camera relative to the tube and provides an acceptable profile for comfortable intubation. Further, the camera apparatus and its associated holder may include additional components, such as integral light sources and flushing or cleaning devices to remove any buildup from the camera or optical components. | 2012-10-11 |
20120259174 | ENDOSCOPIC DIAGNOSIS SYSTEM - An endoscopic diagnosis system includes a light source for simultaneously emitting at least two excitation light having different central wavelengths for exciting at least two autofluorescent substances to generate autofluorescence containing first autofluorescence whose intensity is strong in a lesion and weak in a normal region and second autofluorescence whose intensity is strong in a normal region and weak in a lesion, color filters having spectral transmission characteristics that block the excitation light and transmit the autofluorescence, image sensor for imaging autofluorescence generated from first and second autofluorescent substances contained in a subject's region under observation and dispersed by color filters to acquire first and second autofluorescence images as the at least two excitation light illuminate the region under observation, and an image sensor for image-processing and displaying the first and second fluorescence images. | 2012-10-11 |
20120259175 | BALLOON ACCESS DEVICE FOR ENDOSCOPE - Provided is a balloon access device having a cap coupleable to an endoscope and a balloon for sealing with the cap when expanded. The balloon access device allows a physician to both separate collapsed tissue and visualize the path of the endoscope without administering insufflation gas to the collapsed area of a patient. | 2012-10-11 |
20120259176 | LARYNGOSCOPE ASSEMBLY WITH ENHANCED VIEWING CAPABILITY - A laryngoscope assembly with enhanced viewing capability including a laryngoscope handle having a permanently mounted laryngoscope optical system. The laryngoscope optical system has a view tube with a leading aperture lens for affording a field of view along a deflected line of sight viewing in an operative intubation position. The laryngoscope handle includes a laryngoscope optical system securing arrangement for mechanically securing the laryngoscope optical system in the operative intubation position. The laryngoscope assembly also includes an interchangeable laryngoscope blade including a trailing view tube sleeve for slidably mounting on the view tube and a leading spatula wherein the view tube sleeve has a leading transparent window for covering the aperture lens. The laryngoscope assembly further includes a blade securing arrangement for mechanically securing the laryngoscope blade on the laryngoscope handle in the operative intubation position. | 2012-10-11 |
20120259177 | Overlapping Retractor Blade Assemblies - A retractor assembly for percutaneous surgery in a patient includes first and second retractor portions positionable opposite one another in an incision of the patient. A working channel extends between the first and second retractor portions and provides access to a location within the patient adjacent to distal ends of the first and second retractor portions. The first and second retractor portions are movable relative to one another to adjust the size of the working channel. In addition, the first and second retractor portions are further configured to longitudinally overlap with one another such that the working channel is peripherally surrounded or enclosed by the first and second retractor portions as the working channel is adjusted across a plurality of different sizes. In another form, a method is directed to retracting tissue for percutaneous access to a surgical site. However, other embodiments, forms and applications are also envisioned. | 2012-10-11 |
20120259178 | AUTOMATED SURGICAL ILLUMINATION SYSTEM - The present invention provides illumination for a surgical procedure. Using an optical tracking system, the illumination is made to automatically track an optical marker on a surgical glove worn by a clinician to provide more consistent illumination for a surgical procedure. | 2012-10-11 |
20120259179 | PASSIVE PHYSIOLOGICAL MONITORING (P2M) SYSTEM - Passive physiological monitoring apparatus and method has a sensor for sensing physiological phenomenon. The sensor is a piezoelectric film of polyvinylidene fluoride. A pad may incorporate the PVDF film. The film converts mechanical energy into voltage signals. A microcomputer is used for recording, analyzing and displaying data from the sensor for on-line assessment and for providing realtime response. The sensor may be an array of sensors provided in a MEDEVAC litter or other patient support for measuring acoustic and hydraulic signals from the body of a patient for field monitoring, hospital monitoring, transport monitoring, home, remote monitoring. | 2012-10-11 |
20120259180 | HYDRATION AND NUTRITION SYSTEM - A hydration and nutrition system for monitoring consumption of fluid by a user includes: a reservoir adapted to hold a quantity of fluid; a tube adapted to convey the fluid from the reservoir to the user for consumption; a flow meter adapted to measure and collect data regarding the flow of fluid from the reservoir through the tube and communicate the data regarding the flow of fluid to a computerized nutritional calculator, wherein the computerized nutritional calculator is adapted to calculate a deficit or surplus of fluid consumed as compared to a consumption plan. | 2012-10-11 |
20120259181 | BIOLOGICAL STATE ESTIMATION DEVICE, BIOLOGICAL STATE ESTIMATION SYSTEM, AND COMPUTER PROGRAM - A biological body state estimation device configured such that a homeostatic function level is sorted and acquired in plural stages by using a biological signal obtained from an upper body of a person and each stage of the homeostatic function level is plotted in time series in accordance with a time axis indicated on the lateral axis and displayed as a graph by a display. A highest part on the vertical axis of the graph can be displayed as a highly active state and a lowest part as a function decline state. Therefore, a state of fluctuation due to autonomous nerves as an attempt to maintain homeostasis, progress of a feeling of fatigue, and a state stimulated by activation of the brain can be captured as a periodic function. Moreover, a sleep prediction phenomenon can be captured. | 2012-10-11 |
20120259182 | METHOD AND APPARATUS FOR DETECTING PEAK FROM BIOLOGICAL SIGNAL - A peak detecting method is provided. The peak detecting method includes receiving a biological signal that represents an electrical characteristic difference between electrodes attached to a patient, receiving an activity signal that represents an amount of activity of the patient from an activity sensor detecting activity of the patient, detecting at least one of a plurality of peaks in the input biological signal on the basis of the activity signal, and outputting information regarding the detected peak. | 2012-10-11 |
20120259183 | TRANSIENT SENSOR RESPONSE TO POSTURE AS A MEASURE OF PATIENT STATUS - Patient posture information can be received, such as to indicate a change in patient posture by at least a threshold amount. A transient response signal indicative of a change in a physiological parameter can be received at multiple instances near a change in patient posture. Waveform morphology features can be extracted from a transient response signal and used to provide an indication of a cardiac status, such as a heart failure status. | 2012-10-11 |
20120259184 | BLOOD GLUCOSE MEASUREMENT DEVICE - A blood glucose measuring system comprising: a computer mouse that transmits data to an associated computer; a LED display residing on the computer mouse; a blood glucose strip receiver residing on the computer mouse; a blood glucose measurement mechanism; and software residing on the associated computer which receives blood glucose data, where the software stores the data onto a database within the associated computer. In one exemplary embodiment, the mouse may include two actuation pads and Bluetooth technology to transmit data from the mouse to the associated computer. The LED display provided on the mouse displays the glucose results measured by the measurement means. The software residing on the associated computer tabulates the blood glucose measurements and stores the data in a predetermined format. | 2012-10-11 |
20120259185 | Systems, Methods and Devices for Adjusting the Insertion Depth of a Cannula Associated with a Portable Therapeutic Device - Systems, methods and devices are described herein for adjusting the insertion depth of a cannula associated with a portable therapeutic device within the body of a patient. The systems may include a mounting unit securable to the skin of the patient and having a mounting base and a well defining a passageway through the mounting base and a cannula unit including a cannula subcutaneously insertable through the well of the mounting unit. The well may have an adjustable height and/or adjustable anchoring mechanisms that allow for varying and customized insertion depths of the cannula within the body of the patient. | 2012-10-11 |
20120259186 | Method and apparatus for an improved sample capture device - A body fluid sampling device is provided. A mesh ( | 2012-10-11 |
20120259187 | DYNAMIC COLORECTAL PDT APPLICATION - Dynamic colorectal PDT methods, devices and photosensitizer compositions to treat abnormal cell growth in anal tissue such as perianal and intra-anal intraepithelial neoplasia grade III are presented. Dynamic colorectal PDT method comprises the steps of administering topically, intravenously or orally a photosensitizer composition; irradiating; monitoring treatment parameters before, during and/or after irradiation. Photosensitizer composition comprises Temoporfin and excipients/carriers, appropriate for the application method. An applicator is provided for colorectal PDT treatments enhancing irradiation delivery and monitoring treatment parameters. Preferably, applicator is made of a material, used to monitor the fluence rate simultaneously while doing optical spectroscopy. Measurement probe devices are provided for monitoring PDT treatment parameters in-vivo. A device for colorectal PDT treatment is also provided, comprising laser radiation source operating at about 400 and 800 nm; excitation laser radiation source operating at about 650 nm for fluorescence measurements; multichannel dosimetry device; long pass filter; waveguides and measurement probes. | 2012-10-11 |
20120259188 | Flexible Eye Insert and Glucose Measuring System - Disclosed is a flexible insert ( | 2012-10-11 |
20120259189 | CARDIOVASCULAR INDEX ESTIMATION METHODS - New algorithms to estimate cardiovascular indices by analysis of the arterial blood pressure (ABP) signal. The invention comprises recording and identification of cardiovascular descriptors (including ABP signal, diastolic pressure, systolic pressure, pulse pressure, and end systole), calculation of cardiovascular system parameters, and calculation of aortic blood flow, stroke volume, cardiac output, total peripheral resistance, and characteristic time constant. | 2012-10-11 |
20120259190 | DETECTION OF OXIMETRY SENSOR SITES BASED ON WAVEFORM CHARACTERISTICS - In accordance with an embodiment of the present technique, there is provided methods and systems for detecting the location of a sensor and determining calibration algorithms and/or coefficients for calculation of physiological parameters based on the detected location. An exemplary embodiment includes receiving a signal corresponding to absorption of at least one wavelength of light by a patient's tissue, generating a plethysmographic waveform from the signal, determining an identifying characteristic of the plethysmographic waveform, and determining a location of the sensor based on a comparison of the identifying characteristic with at least one defined criterion. | 2012-10-11 |
20120259191 | SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA - Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. | 2012-10-11 |
20120259192 | MEASURING APPARATUS AND SENSOR PLACEMENT METHOD - Provided are a measurement device, a sensor unit, and a sensor placement method, which enable the suppression of the occurrence of a situation where a measurement carried out with a sensor implanted under the skin, the implanted sensor becomes faulty. A sensor unit is used for measuring numerical information relating to a substance contained in a body fluid in a body. The sensor unit is provided with a sensor a part of which is placed under the skin and generates a signal according to the state of the substance, a base which is disposed on the skin and holds the sensor, a variable mechanism which is attached to the base and enables the position and/or the direction of the sensor with reference to the base to be varied, and an external terminal which is provided in the base and leads the signal generated by the sensor to the outside. | 2012-10-11 |
20120259193 | ELECTRICALLY CONDUCTIVE BALLOON CATHETER - A balloon catheter having a mesh affixed thereto. The mesh is formed having members extending longitudinally and circumferentially about the balloon into columns and rows respectively. Each member of the mesh has a resistance or impedance that changes as the member is deformed such that, when the member comprises a length (L) a measured resistance or impedance will be different than when the member comprise a length (L | 2012-10-11 |
20120259194 | CATHETER HAVING A FORCE SENSING DISTAL TIP - A catheter for contact force sensing includes a catheter body, a deflectable section, and a distal section having a tip electrode and a contact force sensor for sensing a 3D contact force vector applied to the tip electrode. The contact force sensor has a body and at least one sensor with an electrical characteristic responsive to deformation of the body resulting from the force vector. The sensor receives an electrical current and outputs an electrical signal indicative of a change in the electrical characteristic. The sensor may be a strain gage responsive to tension and compression of at least a portion of the body of the force sensor, and the electrical characteristic may be electrical resistivity of the strain gage. Alternatively, the sensor may be responsive to strain and stress of at least a portion of the body, and the electrical characteristic is inductance or hysteresis loss. | 2012-10-11 |
20120259195 | SYSTEM AND METHOD OF MONITORING INTRAOCULAR PRESSURE AND TREATING AN OCULAR DISORDER - The invention discloses a trabecular stent and methods for treating glaucoma. The stent may incorporate an intraocular pressure sensor comprising a compressible element that is implanted inside an anterior chamber of an eye, wherein at least one external dimension of the element correlates with intraocular pressure. In some embodiments, the sensor may be coupled to the stent. Also disclosed are methods of delivery of the stent and the sensor to the eye. | 2012-10-11 |
20120259196 | MEDICAL IMAGE DIAGNOSTIC APPARATUS AND CONTROL METHOD - A medical image diagnostic apparatus according to an embodiment includes a simplified positron emission computed tomography (PET) image data generating unit, a PET image data generating unit, and a display. The simplified PET image data generating unit generates simplified PET image data based on information obtained by projecting the position of a generation source of a gamma ray emitted from a subject to whom a radioisotope is administered onto a predetermined projection surface in a predetermined direction. The PET image data generating unit generates, based on an evaluation result of the simplified PET image data, PET image data by using projection data in the PET imaging mode generated based on a detection result of the gamma ray emitted from the subject. The display displays the simplified PET image data and the PET image data. | 2012-10-11 |
20120259197 | RECTAL BALLOON WITH RADIATION SENSOR AND/OR MARKERS - A rectal balloon apparatus has a shaft with a fluid passageway extending therethrough. A balloon is affixed over an end of the shaft such that the fluid passageway communicates with an interior of the balloon. The balloon has a laterally flat surface thereon when inflated. The laterally flat surface of the balloon has a longitudinal groove formed thereon. The balloon has a radiation sensor positioned within the groove and a plurality of fiducial markers positioned on a surface of the balloon. A stopper is slidably mounted on the shaft. | 2012-10-11 |
20120259198 | SUBJECT INFORMATION PROCESSING APPARATUS - There is provided a subject information processing apparatus including a first acoustic conversion element that receives an acoustic wave having a first frequency reflected inside a subject and converts the acoustic wave into an analog signal, a second acoustic conversion element that receives an acoustic wave having a second frequency generated when light is irradiated to a subject and converts the acoustic wave into an analog signal, an A/D converter that converts the analog signal into a digital signal, a data memory that retains the digital signal, and a controller that instructs the data memory to output the digital signal at a predetermined sampling frequency for each receiving axis. | 2012-10-11 |