40th week of 2012 patent applcation highlights part 53 |
Patent application number | Title | Published |
20120251994 | SYSTEM AND METHOD FOR DIGITAL FLASHCARD USE BY MULTIPLE INTERNET COMMUNITIES - A system and method for an internet community to create and share flashcard decks related to one or more topics is disclosed. An author is responsible for creating flashcard decks while a group lead is responsible for managing access to the decks to a select group of users. Group members use the flashcard decks to learn the content material. An authoring application is used by the authors to create the flashcard decks through the assembly of one or more of rich text, image, audio, and/or video elements. A group management application is used by the group lead for the purpose of creating user groups and managing their access to selected decks as well as various modes of play. A flashcard player is available for web, personal computer, smart phone, and/or tablet use by the group members/users. | 2012-10-04 |
20120251995 | APPARATUS AND METHOD FOR TUTORING IN CONVERGENCE SPACE OF REAL AND VIRTUAL ENVIRONMENT - An apparatus for tutoring in a convergence space of real and virtual environment, includes a character data processing unit for generating character shape and operation data of a participant or performing rendering on the character shape and operation data; a desk data processing unit for generating desk shape data or perform the rendering on the desk shape data; a voice and sound data processing unit for generating voice or sound data or outputs the voice or sound data; and a virtual space processing unit for generating real space data and providing the generated data to another participant, generating the convergence space data, or generating the character shape data, the operation data, the desk shape data, and the voice or sound data, then providing the generated data to the character data processing unit, the desk data processing unit, and the voice and sound data processing unit. | 2012-10-04 |
20120251996 | METHOD AND SYSTEM FOR PLANT MANAGEMENT BY AUGMENTATION REALITY - A plant management method using augmentation reality is provided. A method for providing a plant management screen overlaps and displays a real image of facilities in the plant and a virtual image indicating a facility to check. Hence, by displaying the facilities in the plant using the augmentation reality, the facility inspector can detect and access the facility having a problem more easily. | 2012-10-04 |
20120251997 | STUDENT TERMINAL, ELECTRONIC BLACKBOARD, SERVER, TERMINAL FUNCTION RESTRICTION METHOD AND RECORDING MEDIUM IN WHICH TERMINAL FUNCTION RESTRICTION PROGRAM IS RECORDED - Disclosed is an electronic blackboard which communicates with a student terminal which executes a plurality of terminal functions including a blackboard function execution unit to execute any of a plurality of blackboard functions according to a user's operation, a restriction target function deciding unit to decide types of a plurality of terminal functions in which functions thereof are to be restricted in the student terminal according to a type of blackboard function to be executed, and a restriction target functions transmission unit to transmit the types of the plurality of terminal functions in which functions thereof are to be restricted, which are decided by the restriction target function deciding unit, to the student terminal. | 2012-10-04 |
20120251998 | DEVICE AND METHOD FOR BLOOD TREATMENT WITH SINGLE NEEDLE OPERATION - The present invention relates to a device and a method for blood treatment in a single-needle operating mode. The blood treatment device has an extracorporeal blood circuit comprising a blood supply line leading to the inlet of a blood treatment unit and a blood return line leading away from the outlet of the blood treatment unit. Blood collecting means, for example a blood collecting container, is provided in the blood return line, said means being connected to means for storing gas, for example an air reservoir, by a flow line. The flow connection comprises two line branches, one branch being used to transfer gas from the air reservoir into the blood collecting container and the other branch being used to transfer gas from the blood collecting container into the air reservoir. The connection branch for transferring gas from the air store into the blood collecting container contains means for compressing air, for example a compressor. The device according to the present invention may be operated in such a way that the filling level of the means for collecting blood can be determined as precisely as possible. | 2012-10-04 |
20120251999 | VITRIFICATION SYSTEMS AND METHODS - The embodiments of the invention described herein relate to systems and methods for the vitrification of biological samples. Vitrification is achieved by generating nanodroplets of a solution comprising the biological sample with a means that can be automated and adapted to high-throughput applications. | 2012-10-04 |
20120252000 | REAL TIME MULTIPOINT ASSAY FOR OPTIMIZING PERFORMANCE - Described herein are methods of optimizing the performance of a mammalian semen sample with respect to outcomes such as fertility, using a multipoint assay to determine an optimum time point for preparing the semen sample for use in insemination. The multipoint assay is based upon a kinetic model of biomarker expression during sperm capacitation relative to the outcome of interest. | 2012-10-04 |
20120252001 | Method of Blood Pooling and Storage - The disclosure provides methods of making a red blood cell, plasma, and platelet products having a uniform dose and volume. The method comprises pooling a plurality of blood units, leukoreducing the blood and inactivating any pathogen contained therein. Plasma, RBCs, and platelets are then divided into uniform dose and volume units which have an extended shelf life. | 2012-10-04 |
20120252002 | FLUORESCENT NANOPARTICLE COMPOSITES THEMSELVES, PROCESS FOR THE PREPARATION OF SUCH COMPOSITES, AND USE IN RAPID DIAGNOSIS SYSTEMS WITH AFFINITY TO BIOLOGICAL MOLECULES - The present invention provides fluorescent nanoparticle composites themselves, the process of preparing such composites, to systems for rapid diagnosis (as “kits”) containing such composites, and to the use of such composites. In a preferential embodiment, the composites of the present invention have an affinity for biological molecules, such as DNA. The present invention also comprises the preparation of probes containing biological material, upon which are added fluorescent nanoparticle composites, making viable a rapid and economic biological diagnosis of, for example, diseases and genetic traits, notably in the medical and veterinarian fields. There is yet the fact that the absorption of radiation in the ultraviolet and visible regions, with the emission of light in the near ultraviolet and visible range, including in the colors of deep blue and/or green, provides advantageous use of its fluorescent properties in photovoltaic or electroluminescent devices, such as organic LEDs, or for the increase in luminous gain of fluorescent lamps, which represents another characteristic of the invention. | 2012-10-04 |
20120252003 | Bacteria Identification by Phage Induced Impedance Fluctuation Analysis - Methods for detection and identification of bacteria within a sample include the step of inserting a pair of electrodes into the sample. A first impedance across the electrodes is established with a first AC voltage source having a first frequency. A phage is introduced into the sample, and impedance fluctuations that are caused by ion release by the bacteria due to the phage introduction are measured. The use of impedance fluctuations instead of voltage fluctuations to detect and identify bacteria minimizes 1/f noise effects and increases system sensitivity. To further increase system sensitivity by eliminating thermal noise, a second impedance across the electrodes can be established using a second AC voltage source at a second frequency. Second impedance fluctuations are cross-correlated to the first impedance fluctuations, and the cross-correlation results are analyzed to determine whether or not bacteria are present in the sample based on phage electrical activity. | 2012-10-04 |
20120252004 | HIGHLY SENSITIVE IMMUNOCHROMATOGRAPHY METHOD - Provided is an immunochromatography method that enables highly sensitive detection by reducing the background density of a non-measurement site in the immunochromatography method. The immunochromatography method includes developing a complex of a substance to be tested and a labeling substance containing a metal modified with a first binding substance for the substance to be tested on an insoluble carrier in the presence of a surfactant having a steroid skeleton while the substance to be tested and the labeling substance form the complex; and detecting the complex of the substance to be tested by capturing the substance to be tested and the labeling substance on a detection site of the insoluble carrier containing a second binding substance for the substance to be tested or a substance that can bind to the first binding substance for the substance to be tested. | 2012-10-04 |
20120252005 | MULTI-WAVELENGTH ANALYSES OF SOL-PARTICLE SPECIFIC BINDING ASSAYS - The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner. | 2012-10-04 |
20120252006 | Methods and Systems for Multiple Control Validation - The invention provides methods for validating a multiplex binding assay that results in a reduced number of false invalidations. The invention further provides systems for validating a multiplex binding assay that results in a reduced number of false invalidations. The invention further provides a computer readable medium containing program instructions for validating a multiplex binding assay that results in a reduced number of false invalidations. | 2012-10-04 |
20120252007 | OPTIMIZED REAL TIME NUCLEIC ACID DETECTION PROCESSES - This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided. Paneling and multiplex analyses of more than one nucleic acid analyte using one sample are also provided. | 2012-10-04 |
20120252008 | COMPOSITIONS AND METHODS FOR CAPTURE AND ELUTION OF BIOLOGICAL MATERIALS VIA PARTICULATES - Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content. | 2012-10-04 |
20120252009 | Methods and Compositions for Enriching Either Target Polynucleotides or Non-Target Polynucleotides from a Mixture of Target and Non-Target Polynucleotides - Compositions and methods are provided for enriching non-target polynucleotides from a mixture of non-target and target polynucleotides where differences between the target polynucleotides and the non-target polynucleotides include the extent of modified bases that are present in a greater density in the target polynucleotides than in the non-target polynucleotides. This permits the target polynucleotides to be selectively and rapidly bound to an affinity matrix such as affinity protein-coated magnetic beads providing enrichment of the non-target polynucleotides in the supernatant. One use of this enrichment is to remove human genomic DNA from a mixture of DNAs obtained from human tissue samples to enrich for polynucleotides in a microbiome so as to characterize the microbiome by DNA sequencing. | 2012-10-04 |
20120252010 | LABELLED NUCLEOTIDES - Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group. | 2012-10-04 |
20120252011 | COMPOSITION FOR TREATMENT OF PANCREATIC CANCER - Disclosed is a composition for treating pancreatic cancer. The composition comprises a pharmaceutically effective amount of an antisense nucleic acid or siRNA that inhibits expression of at least one gene selected from the group consisting of SON gene, MCM5 gene, WDR5 gene, PBK gene and CENPA gene. The composition inhibits the expression of a specific gene to provide the effect of inhibiting the proliferation, survival and tumorigenicity of pancreatic cancer cells. | 2012-10-04 |
20120252012 | METHOD FOR DETECTING PROKARYOTIC DNA FROM A FECES SAMPLE - The present invention concerns a method of detection and preferably of quantification of DNA, preferably comprising prokaryotic DNA, extracted from a stool sample of an individual, especially for the molecular determination of the composition of the intestinal flora in the stool. According to the invention, one controls the quality of the DNA extraction by verifying whether one detects a specific DNA of | 2012-10-04 |
20120252013 | METHODS FOR IDENTIFYING MULTIPLE DNA ALTERATION MARKERS IN A LARGE BACKGROUND OF WILD-TYPE DNA - Methods for simultaneously surveying the status of a large number of DNA mutation markers are described. In addition, methods for simultaneously determining the methylation status at multiple sites of a collection of genes, in a single assay, are described. | 2012-10-04 |
20120252014 | METHOD OF NORMALIZED QUANTIFICATION OF NUCLEIC ACIDS USING ANCHOR OLIGONUCLEOTIDES AND ADAPTER OLIGONUCLEOTIDES - The present invention is related to normalized quantification of nucleic acids and to the normalization of quantities of nucleic acids in samples, e.g. mixtures of nucleic acids. The present invention relates to method for the normalization of the quantity of a nucleic acid to be quantified in a sample to the total quantity of nucleic acid in the sample; or to the total quantity of a specific class of nucleic acid in the sample. | 2012-10-04 |
20120252015 | METHODS AND COMPOSITIONS FOR DETECTING GENETIC MATERIAL - The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a sample. The present disclosure also provides methods and compositions for determining the load of fetal polynucleotides in a biological sample, e.g., the load of fetal polynucleotides (e.g., DNA, RNA) in maternal plasma. The present disclosure provides methods and compositions for detecting cellular processes such as cellular viability, growth rates, and infection rates. This disclosure also provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some embodiments, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). | 2012-10-04 |
20120252016 | OPTIMIZED OLIGONUCLEOTIDES AND METHODS OF USING SAME FOR THE DETECTION, ISOLATION, AMPLIFICATION, QUANTITATION, MONITORING, SCREENING, AND SEQUENCING OF GROUP B STREPTOCOCCUS - Described herein are oligonucleotides useful for detecting, isolating, amplifying, quantitating, monitoring, screening and sequencing GBS genes and methods of using the described oligonucleotides. | 2012-10-04 |
20120252017 | DEVICE AND METHOD FOR EXTRACTION AND ANALYSIS OF NUCLEIC ACIDS FROM BIOLOGICAL SAMPLES - Device and methods for extracting and analyzing nucleic acids from biological samples. | 2012-10-04 |
20120252018 | METHOD OF DETECTING AN ANALYTE IN A SAMPLE USING SEMICONDUCTOR NANOCRYSTALS AS A DETECTABLE LABEL - The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength. | 2012-10-04 |
20120252019 | Detection of Bladder Cancers - The present invention generally relates to methods of screening for cancer. Methods of the invention involve identifying a threshold parameter of a protein and of two or more nucleic acids, where the threshold parameters are indicative of the absence of cancer, conducting an assay in a sample to determine a parameter of the two or more nucleic acids and a parameter of the protein, and identifying the sample as positive for cancer if the parameters of at least one of the nucleic acids and the protein present in the sample are greater than their respective threshold parameters. In certain aspects of the invention, the nucleic acids include FGFR3, TWIST1, and NID2. In certain aspects of the invention, the protein includes MMP2 or MMP9. | 2012-10-04 |
20120252020 | Screening Assay for Bladder Cancer - The present invention generally relates to methods of screening for cancer. Methods of the invention involve identifying a threshold parameter of a protein and of two or more nucleic acids, where the threshold parameters are indicative of the absence of cancer, conducting an assay in a sample to determine a parameter of the two or more nucleic acids and a parameter of the protein, and identifying the sample as positive for cancer if the parameters of at least one of the nucleic acids and the protein present in the sample are greater than their respective threshold parameters. In certain aspects of the invention, the nucleic acids include FGFR3, p53, TWIST1, Vimentin, and NID2. In certain aspects of the invention, the protein includes MMP2 or MMP9. | 2012-10-04 |
20120252021 | DOPAMINERGIC NEURON PROGENITOR CELL MARKER 187A5 - An object of the present invention is to provide a probe, a primer, a primer set and an antibody for use in the detection or selection of a dopaminergic neuron progenitor cell. The present invention provides a probe, a primer and a primer set for use in the detection or selection of a mesencephalon dopaminergic neuron progenitor cell, and preferably a dopaminergic neuron proliferative progenitor cell, which can hybridize with a nucleotide sequence of a 187A5 gene, or a complementary sequence thereto, and an antibody for use in the detection or selection of a mesencephalon dopaminergic neuron progenitor cell, and preferably a dopaminergic neuron progenitor cell, which is capable of binding to a 187A5 protein. | 2012-10-04 |
20120252022 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF THYROID CANCER - Methods for detecting, diagnosing and monitoring thyroid cancer in a subject are described comprising measuring in a sample from the subject markers including Ep-ICD and β-catenin. The invention also provides kits and compositions for carrying out the methods of the invention. | 2012-10-04 |
20120252023 | Materials and Methods Useful for Affecting Tumor Cell Growth, Migration and Invasion - It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein. | 2012-10-04 |
20120252024 | Probe for Detection of Polymorphism in C-Kit Gene and Use Thereof - The present invention provides probes that can identify different polymorphisms in a c-kit gene easily with high reliability and use thereof. | 2012-10-04 |
20120252025 | METHODS FOR COVALENT LINKING OF OPTICAL REPORTERS - A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particle generated by the methods of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR. | 2012-10-04 |
20120252026 | CANCER BIOMARKER, DIAGNOSTIC METHODS, AND ASSAY REAGENTS - This disclosure describes APOBEC3B as a biomarker for certain cancers such as, for example, breast cancer. This disclosure therefore describes methods for detecting APOBEC3B in a biological sample. The methods generally include measuring expression of APOBEC3B in a biological sample obtained from a patient and identifying the patient as having or at risk for having cancer if the measured expression of APOBEC3B is greater than a predetermined reference level of expression. This disclosure also describes isolated polynucleotides that may be used as reagents in methods for detecting and/or measuring APOBEC3B expression. | 2012-10-04 |
20120252027 | Method For Rapidly Evaluating Performance Of Short Interfering RNA With Novel Chemical Modifications - It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy. | 2012-10-04 |
20120252028 | TARGET GENES FOR CANCER THERAPY - The invention provides new gene targets for cancer chemotherapy, their use in assays for identifying new small molecule cancer chemotherapeutic agents, methods for inhibiting cancer cell growth comprising contacting a cell with a gene expression blocking agent that inhibits the expression of such genes and methods for therapeutic treatment of cancer in a mammal, comprising administering to the mammal such a gene expression blocking agent. A preferred gene target is coatomer protein zeta-1 subunit (COPZ1). | 2012-10-04 |
20120252029 | SIMULTANEOUS QUANTITATIVE MULTIPLE PRIMER DETECTION OF CLOSTRIDIUM DIFFICILE - This invention comprises a multiplex-capable oligonucleotide which is capable of hybridizing to at least one of the | 2012-10-04 |
20120252030 | 5-BROMO-2'-DEOXY-URIDINE LABELED NUCLEOTIDE TRIPHOSPHATES AND NUCLEIC ACID PROBES AND METHODS OF MAKING AND USING THE SAME - 5-bromo-2′-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide triphosphate and the BrdU moiety. The linker can be cleavable or non-cleavable. The nucleotide triphosphates can be a ribonucleotide triphosphates, 2′-deoxyribonucleotide triphosphates or 2′,3′-dideoxyribonucleotide triphosphates. The nucleic acid probes can be used for in situ hybridization. | 2012-10-04 |
20120252031 | COMPOSITIONS AND METHODS FOR REGULATING SAS1R - The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor. Six SAS1R variants, including the full length SAS1R, were identified. mSLLP1 and SAS1R co-localized to oocytes and to acrosomes of acrosome-reacted sperm. Interactions between mSLLP1 and SAS1R were demonstrated by far-western analysis, in a yeast two-hybrid system under stringent selection conditions, and by immunoprecipitation of SAS1R by anti-mSLLP1 as well as the converse. Purified recombinant SAS1R was found to have protease activity, to inhibit fertilization in-vitro, and to induce an immune response in females. Together, the results suggest SAS1R is a proteolytically active, oocyte and early embryo specific oolemmal metalloprotease receptor for the sperm intra-acrosomal ligand SLLP1 and is a target for regulating fertilization and as a contraceptive. | 2012-10-04 |
20120252032 | Immunoassay Device with Improved Sample Closure - An apparatus and method for sealing a fluid sample collection device, comprising loading a fluid sample collection device with a fluid sample, said device comprising a housing having at least one substantially planar surface that includes an orifice in fluid communication with an internal fluid sample holding chamber which terminates at an internal capillary stop; and slidably moving a sealing element over at least a portion of said substantially planar surface in a way that displaces any excess fluid sample away from the orifice, seals the fluid sample within said holding chamber, and inhibits the fluid sample from prematurely breaking through the internal capillary stop. | 2012-10-04 |
20120252033 | SUBSTANCE DETERMINING APPARATUS - The invention relates to a substance determining apparatus and method for determining a substance within a fluid. Particles attach to the substance and bind to a binding surface ( | 2012-10-04 |
20120252034 | QUALITY ASSAYS FOR ANTIGEN PRESENTING CELLS - The present invention provides methods for evaluating the quality of a preparation of antigen presenting cells, such as dendritic cells. Assays for antigen-independent co-stimulation of T cells and for presentation of predetermined antigen by APCs are provided | 2012-10-04 |
20120252035 | GDF-15 and/or Troponin T for Predicting Kidney Failure in Heart Surgery Patients - The present disclosure relates to the field of laboratory diagnostics. Specifically, means and methods are disclosed for determining a patient's risk of suffering from acute kidney injury after a surgical procedure based on the detection of GDF-15, troponin T and/or a natriuretic peptide. | 2012-10-04 |
20120252036 | DIAGNOSTIC TESTS FOR ABNORMAL OVARIAN CONDITIONS - Methods and compositions, and a kit for diagnosing ovarian disorders including autoimmunity and ovarian cancer. Ovarian autoimmunity is associated with unexplained infertility or idiopathic premature ovarian failure that occurs in the absence of polyglandular disease. Methods and composition described herein are used to detect ovarian autoimmunity before the onset of ovarian dysfunction. Thus, those individuals are identified who would benefit from therapy to maintain, as well as restore, ovarian function. | 2012-10-04 |
20120252037 | STIMULATORY AUTO-ANTIBODIES TO THE PDGF RECEPTOR AS PATHOLOGY MARKER AND THERAPEUTIC TARGET - An in vitro method for detecting the presence in a body sample of auto-antibodies for the PDGF receptor suitable for the diagnosis and prognosis of autoimmune diseases, in particular the systemic sclerosis and related diagnostic kits. Use of an inhibitor of ROS and/or Ras-ERK1/2 for the preparation of a medicament for therapeutic treatment of autoimmune diseases or of treating the Graft-Versus-Host-Reaction (GVHR). Pharmaceutical composition comprising an effective amount of an inhibitor of ROS and/or Ras-ERK1/2, and proper diluents, and/or excipients, and/or adjuvants. | 2012-10-04 |
20120252038 | STEROID RECEPTOR ASSAYS - Methods for the detection, enumeration and analysis of circulating tumor cells expressing steroid receptors, particularly estrogen receptors are disclosed. These methods are useful for cancer screening and staging, development of treatment regimens, and for monitoring for treatment responses, cancer recurrence or the like. Test kits that facilitate the detection, enumeration and analysis of such circulating tumor cells are also provided. | 2012-10-04 |
20120252039 | PLASMA KALLIKREIN FRAGMENTS AS DIAGNOSTIC BIOMARKERS FOR LUNG CANCERS - Disclosed herein are diagnostic markers for lung cancer, isolated from serum glycoproteins. The disclosed diagnostic markers for lung cancer are specifically expressed only in the sera of lung cancer patients at high levels, and thus will be very useful for diagnosing lung cancer and estimating disease progression and treatment. | 2012-10-04 |
20120252040 | KIT FOR DIAGNOSING PROSTATE CANCER AND DIAGNOSIS METHOD - The present invention relates to a kit and method for diagnosing prostate cancer, which use an antibody to prostate-specific antigen (PSA) to detect PSA in human urine. More specifically, the invention relates to a kit for diagnosing prostate cancer, which comprises an antibody to PSA and uses human urine as a sample, and to a method for diagnosing prostate cancer, which comprises brining a human urine sample into contact with an antibody to PSA in order to detect PSA in the sample. | 2012-10-04 |
20120252041 | METHOD OF PROGNOSIS - The present invention relates to the use of soluble CD163 as a prognostic marker for the assessment of the risk for contracting a disorder, in particular for contracting diabetes and/or a liver disorder. The invention also relates to the use of CD163 as a prognostic marker for assessing lifetime expectancy. | 2012-10-04 |
20120252042 | Artificial Feces - A composition to simulate feces. A method of using artificial feces to evaluate the efficacy of a cleaning product and/or cleaning procedure. A method of demonstrating the cleaning efficiency of a cleaning product and/or cleaning procedure using artificial feces. | 2012-10-04 |
20120252043 | BLOOD COAGULATION TIME DETERMINATION METHOD AND APPARATUS - The invention relates to a method for determining the coagulation time of a sample fluid containing blood components by means of a resonator whose vibration parameters are measured and then used as a basis for determining the sample fluid viscosity change, which resonator has an at least partially adhesive surface contacting said sample fluid. The invention is characterized by preincubation of said surface with a preincubation fluid containing blood components, which preincubation fluid has a known way of interacting with the coagulation system, thus resulting in anchoring sites to be formed on the adhesive areas of said surface. | 2012-10-04 |
20120252044 | Controls and kit for thrombocyte activity tests - The present invention is in the field of coagulation diagnostics and relates to a kit and method for preparing controls for use in test methods for determining thrombocyte function. | 2012-10-04 |
20120252045 | METHOD OF ASSESSING ISLET FUNCTION - A method for assessing islet function comprising determining an oxygen consumption rate (OCR) of the islets; determining an islet index (II) of the islets; and determining an OCR/II ratio, wherein a high OCR/II ratio correlates with increased islet function. The methods may be performed on islets in vitro. In some embodiments, the methods may be performed on islets to be used for transplantation after they are harvested from a donor pancreas and prior to transplanting the islets into a recipient. | 2012-10-04 |
20120252046 | TRANSDERMAL SYSTEMS, DEVICES, AND METHODS FOR BIOLOGICAL ANALYSIS - A transdermal test sensor includes a test chamber including a liquid, a reagent system in contact with the liquid, a housing containing the liquid, and a semipermeable membrane. The housing includes an opening, the semipermeable membrane is connected to the housing and covers the opening, and the housing and the semipermeable membrane enclose the liquid and the reagent system. The transdermal test sensor also includes an analyzer in communication with the liquid. When porated tissue is contacted with the semipermeable membrane and sufficient time is allowed for a fluid sample to traverse the porated tissue and for an analyte in the fluid sample to enter the liquid in the transdermal sensor through the semipermeable membrane, a change in at least one optical property or at least one electrical property of the liquid is detected. The change detected is then correlated with the analyte concentration in the fluid sample. | 2012-10-04 |
20120252047 | SALICYLIC ACID DERIVATIVES WITH FLUOROPHORES AND METHOD OF MAKING AND USING THE SAME - A latent fluorophore is derived from salicylic acid, and containing a fluorogenic group and a moiety represented by formula I | 2012-10-04 |
20120252048 | COMPOSITIONS COMPRISING A DEHALOGENASE SUBSTRATE AND A CONTRAST AGENT AND METHODS OF USE - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 2012-10-04 |
20120252049 | METHODS OF DETECTING MICROORGANISMS AND KITS THEREFORE - A method of detecting microorganisms in a test sample is provided. The method includes the steps of: a) incubating the test sample with a growth media to form an incubated sample, wherein the growth media includes an enzyme substrate and the enzyme substrate includes an enzymatically hydrolysable group and a fluorescent group, wherein microorganisms present in the test sample include an enzyme that hydrolyzes the hydrolysable group from the fluorescent group to form a fluorescently detectable product, wherein the fluorescently detectable product has both an acidic and basic species; b) exciting the fluorescently detectable product with light having a wavelength of Exλiso for a time sufficient for the fluorescently detectable product to emit light, wherein Exλiso is the absorbance isosbestic point of the fluorescently detectable product; and c) detecting light emitted at a wavelength of Emλ1. | 2012-10-04 |
20120252050 | METHODS FOR ASSESSING RISK OF BONE FRACTURE - The invention generally relates to methods for assessing risk of bone fracture. In certain embodiments, methods of the invention involve a) conducting an assay to determine a characteristic of keratinized tissue obtained from a mammal, b) analyzing at least one bone-fracture risk factor associated with the mammal, and c) correlating results from steps (a) and (b), thereby assessing the risk of bone fracture of a bone of the mammal. | 2012-10-04 |
20120252051 | TLR8 TRANSGENIC ANIMALS - Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic animals and methods of use thereof. | 2012-10-04 |
20120252052 | METHOD FOR MULTIPLE QUANTIFICATION OF AMINO GROUP-CONTAINING NON-PEPTIDIC COMPOUND WITH HIGH EFFICIENCY AND HIGH SENSITIVITY AND KIT THEREFOR - A method of quantifying a target non-peptidic compound having an amino group contained in one or more biological samples, which comprises a step of producing a difference in the mass of the target non-peptidic compound between samples, by using a combination of two or more kinds of stable isotopes of a compound represented by the formula (I): | 2012-10-04 |
20120252053 | REAGENTS AND METHODS AND SYSTEMS USING THEM - Certain embodiments described herein are directed to a reagent that includes an effective amount of an adsorber to remove interfering species present during heavy metal level measurement in a fluid sample. In some examples, the reagent can include an effective amount of an adsorber to remove a suitable amount of glutathione from the fluid sample such that the glutathione does not interfere with measurements of lead levels in the fluid sample. | 2012-10-04 |
20120252054 | SYSTEM FOR TRANSFORMATION OF THE CHLOROPLAST GENOME OF SCENEDESMUS SP. AND DUNALIELLA SP. - The present disclosure relates to methods of transforming various species of algae, for example, algae from the genus | 2012-10-04 |
20120252055 | ARRANGEMENT AND METHOD USING MICROSENSORS FOR MEASURING CELL VITALITIES - An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a centre-to-centre in the range of micrometers. The pH and/or pO | 2012-10-04 |
20120252056 | IMAGING METHOD AND SYSTEM USING SUBSTRATE FUNCTIONALIZATION - An imaging system for analyzing fluorescent molecules in a sample, including a confocal microscope device, has a support in contact with at least a portion of the sample. In the system, the support surface in contact with the sample is functionalized so as to reduce the observation volume of the microscope on the surface in the axial direction. The present disclosure also relates to various uses of such a system as well as to a method for analyzing fluorescent molecules in a sample, the method being implemented by such a system. | 2012-10-04 |
20120252057 | METHOD AND DEVICE FOR DETECTING TUMOROUS LIVING CELL TISSUE - The invention relates to a method and to an apparatus for recognizing tumorous living cell tissue. It furthermore relates to a method and to an apparatus for recognizing tumorous cell tissue at collected living cell tissue samples. In the method, electromagnetic radiation is emitted with local definition onto cell tissue by a radiation source and, after deactivation of the radiation source, the decay behavior of the inherent fluorescence intensity of the cell tissue excited by the electromagnetic radiation is detected at the cell tissue in a time resolved and spectrally resolved manner at known sampling rate(s) for at least one wavelength using a detector. The difference autocorrelation function C(t) of the intensity decay behavior is determined using the determined measured intensity values, the fractal dimension D | 2012-10-04 |
20120252058 | System and Method for the Assessment of Biological Particles in Exhaled Air - A system and method for the deposition and analysis of a sample comprising exhaled particles. The sample may be deposited on a substrate and regions of interest comprising exhaled particles may be targeted using autofluorescence. Regions of interest comprising exhaled particles may then be interrogated to thereby generate a spectroscopic data set. This spectroscopic data set may be compared to a reference data set associated with at least one of the following: a known disease state, a known metabolic state, a known inflammatory state, a known immunologic state, a known infectious state, and combinations thereof. | 2012-10-04 |
20120252059 | FLUORESCENT DERIVATIVES OF POLYAMINES, METHOD FOR PREPARING SAME AND APPLICATIONS THEREOF AS DIAGNOSIS TOOLS IN THE TREATMENT OF CANCEROUS TUMORS - The invention relates to novel fluorescent derivatives of polyamines having a benzoxadiazole group, to a method for preparing the same and to the use thereof as diagnosis tools for emphasising the polyamine transport system in cancerous cells in order to adapt the treatment thereof, and thus for selecting patients carrying such tumours in order to adapt their treatment. The derivatives are of the formula (I) or a pharmaceutically acceptable salt thereof, in which: R | 2012-10-04 |
20120252060 | Self-Renewing Single Human Hematopoietic Stem Cells, an Early Lymphoid Progenitor and Methods of Enriching the Same - This invention relates to human hematopoietic stem cells. Specifically the invention relations to the identification of single human hematopoietic stem cells capable of long-term multilineage engraftment and self-renewal. The invention also relates to an early lymphoid progenitor with monocytic potential, including dendritic cell potential. | 2012-10-04 |
20120252061 | NOVEL YEAST STRAINS FOR THE PRODUCTION OF ALCOHOL - The present invention relates to novel yeast strains intended for alcohol production. | 2012-10-04 |
20120252062 | Method for diagnosing and/or predicting the development of neurodegenerative diseases - The present invention relates to a method for diagnosing and/or predicting the development of neurodegenerative diseases; in the method, white blood cells are isolated and enriched or cultivated for forming colony-forming units, wherein CFU-M and other CFU are formed. Subsequently, the relative number of CFU-M formed in the previous cultivation(/enrichment step relative to the other CFUs formed are determined. | 2012-10-04 |
20120252063 | SUBSTITUTED ANTHRAQUINONE DYES FOR CELLULAR STAINS AND ENZYME DETECTION - The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye. | 2012-10-04 |
20120252064 | Protease Enzyme and Uses Thereof - The present invention is related to a fungal serine protease enzyme, which said enzyme has serine protease activity and comprises an amino acid sequence of | 2012-10-04 |
20120252065 | AQUEOUS PROCESS FOR PREPARING PROTEIN ISOLATE AND HYDROLYZED PROTEIN FROM AN OILSEED - The present disclosure relates to an aqueous process for the preparation of a protein isolate and a hydrolyzed protein concentrate from an oilseed meal, optionally comprising:
| 2012-10-04 |
20120252066 | METHODS OF FOAM CONTROL - The invention relates to a method for decreasing foam formation as well as maximizing expression of a biosurfactant in a microorganism. The methods encompasses precipitating a biosurfactant from the microorganism which results in decreased form formation. | 2012-10-04 |
20120252067 | Systems for the Expression of Orthogonal Translation Components in Eubacterial Host Cells - The invention related to compositions and methods for the in vivo production of polypeptides comprising one or more unnatural amino acids. Specifically, the invention provides plasmid systems for the efficient eubacterial expression of polypeptides comprising one or more unnatural acids at genetically-programmed positions. | 2012-10-04 |
20120252068 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2012-10-04 |
20120252069 | PROCESS FOR THE PURIFICATION OF GLYCOPROTEINS - The present invention relates to a process for the purification of a glycoprotein comprising subjecting a liquid containing said glycoprotein to the steps of: a) reverse phase chromatography, b) size exclusion chromatography, and c) hydrophobic interaction chromatography. Also provided is a manufacturing process for producing a glycoprotein of interest. | 2012-10-04 |
20120252070 | BIOMASS SHOCK PRETREATMENT - Methods and apparatus for treating biomass that may include introducing a biomass to a chamber; exposing the biomass in the chamber to a shock event to produce a shocked biomass; and transferring the shocked biomass from the chamber. In some aspects, the method may include pretreating the biomass with a chemical before introducing the biomass to the chamber and/or after transferring shocked biomass from the chamber. | 2012-10-04 |
20120252071 | T7 RNA POLYMERASE VARIANTS WITH CYSTEINE-SERINE SUBSTITUTIONS - The present disclosure provide novel variants of T7 RNA polymerase. Embodiments of T7 variants, according to the instant invention, include a Cysteine-Serine substitution on position 723 of the amino acid sequence of the T7 polypeptide. Embodiments of T7 variants according to the instant invention have a DNA-dependent RNA polymerase enzymatic activity and a reduced tendency to form intramolecular homodimers by way of oxidizing thiol groups. The amino acid substitutions within the T7 variants disclosed herein impact minimally, if at all, the RNA polymerase activity of the T7 polypeptide. Further, the mutations of the disclosed embodiments may optionally be combined with mutations which provide enhanced thermostability compared to the wild-type reference. | 2012-10-04 |
20120252072 | RESTRICTION/MODIFICATION POLYPEPTIDES, POLYNUCLEOTIDES, AND METHODS - The present invention relates to the discovery of a novel restriction/modification system in | 2012-10-04 |
20120252073 | METHOD AND COMPOSITION FOR TREATING STUBBLE - A method of decomposing stubble, which is crop residue left on the ground, and a composition for treating the stubble are disclosed. The method comprises treating the stubble with the composition comprising a) polysaccharide-degrading enzyme; b) wetting agent; and, optionally, c) water and allowing the treated stubble to remain on the ground and decompose. | 2012-10-04 |
20120252074 | PENTOSE FERMENTATION BY A RECOMBINANT MICROORGANISM - The present invention provides methods and compositions suitable for use in the conversion of xylose to xylitol and xylulose, including nucleic acid constructs, recombinant fungal host cells, and related materials. | 2012-10-04 |
20120252075 | Microorganism and Method for the Fermentative Production of an Organic-Chemical Compound - The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided. | 2012-10-04 |
20120252076 | METHOD FOR PRODUCING L-CYSTEINE - A method for producing L-cysteine and the like is provided by developing a novel technique for improving bacterial L-cysteine-producing ability. The method includes the steps of culturing a bacterium belonging to the genus | 2012-10-04 |
20120252077 | USE OF INDUCIBLE PROMOTERS IN THE PRODUCTION OF METHIONINE - The present invention relates to use of inducible promoters in the production of methionine by fermentation. The present invention concerns a method for the production of methionine, its precursors or derivatives in a fermentative process comprising the following steps:
| 2012-10-04 |
20120252078 | Microorganism Which Produces L-Amino Acid and Method for Producing L-Amino Acid Using the Same - The present invention relates to a microorganism belonging to the genus | 2012-10-04 |
20120252079 | YARROWIA DIACYLGLYCEROL ACYLTRANSFERASE PROMOTER REGIONS FOR GENE EXPRESSION IN YEAST - Promoter regions associated with the | 2012-10-04 |
20120252080 | METABOLIC PATHWAY TARGETING BY TRANSCRIPTION FACTOR OVEREXPRESSION - The invention provides microorganisms such as cyanobacteria genetically engineered to express proteins that include transcription factor domains for upregulation of lipid biosynthetic pathways. In addition to expression a gene encoding a transcription factor domain protein, the recombinant microorganisms can express at least one exogenous gene that encodes a polypeptide for the production of a fatty acid, fatty acid derivative, or triglyceride. Also included are methods of producing a fatty acid, fatty acid derivative, or triglyceride using the engineered microorganisms described herein as well as nucleic acid molecules encoding novel transcription factor domain proteins. | 2012-10-04 |
20120252081 | USING CELL DEBRIS GENERATED FROM PHA RECOVERY FOR ENHANCED CELL GROWTH AND BIOPOLYESTER FORMATION - The present invention relates to a process for producing biodegradable polymeric materials including polyhydroxyalkanoates (PHAs) by using the cell debris left from PHA recovery and purification. The process comprises: (a) cultivating PHA-producing microbial cells in a medium solution containing an organic carbon source to form PHAs that are accumulated in the cells as inclusion bodies; (b) harvesting the cells from the spent medium and solubilizing the non-PHA cell mass to obtain a PHA solid and a cell debris solution; (c) separating the PHA solid from the cell debris solution; (d) feeding the cell debris solution to the cultivation step (a). By reusing the cell debris generated from PHA recovery, the invention avoids disposal of a large amount of aqueous waste. In addition, a remarkable increase of cell growth and PHA synthesis is achieved, because the cell debris can be readily assimilated by the microbial cells as the nutrients. | 2012-10-04 |
20120252082 | Fermentation Process For Controlling Butanediol Production - Methods for improving the efficiency of 2,3-butanediol fermentations are disclosed. More specifically methods of increasing the butanediol productivity from the anaerobic fermentation of a substrate comprising carbon monoxide or carbon monoxide and hydrogen by one or more caboxydotrophic acetogenic bacteria are disclosed. The method includes supplying a hydrogen depleted substrate to increase butanediol productivity. The method includes producing butanediol at a volumetric productivity rate of at least 15 g/L/day. | 2012-10-04 |
20120252083 | FERMENTATION PROCESS FOR PRODUCING ISOPROPANOL USING A RECOMBINANT MICROORGANISM - The invention provides, inter alia, methods for the production of acetone, isopropanol and/or precursors of acetone and/or isopropanol by microbial fermentation of substrates comprising CO, genetically modified microorganisms of use in such methods, nucleic acids suitable for preparation of genetically modified microorganisms, a novel alcohol dehydrogenase and nucleic acids encoding same. | 2012-10-04 |
20120252084 | Enhanced Pyruvate to Acetolactate Conversion in Yeast - A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having acetolactate as an upstream intermediate benefit from the increased conversion of pruvate to acetolactate in the described strains. | 2012-10-04 |
20120252085 | METHOD FOR THE PRODUCTION OF A FERMENTATION PRODUCT FROM A PRETREATED LIGNOCELLULOSIC FEEDSTOCK - A method for obtaining a fermentation product from a sugar hydrolysate obtained from a feedstock containing hemicellulose, by (i) removing suspended fiber solids from said sugar hydrolysate to obtain a clarified sugar solution; (ii) fermenting xylose in the clarified sugar solution in a fermentation reaction with yeast to produce a fermentation broth comprising the fermentation product; (iii) separating the yeast from the fermentation broth to produce a yeast slurry; (vi) treating the yeast slurry thus obtained with an oxidant to kill microbial contaminants, thereby an oxidant-treated yeast slurry; (v) re-introducing at least a portion of the oxidant-treated yeast back to step (ii) to increase the concentration of yeast in said fermentation reaction; and (vi) recovering the fermentation product. | 2012-10-04 |
20120252086 | Compositions Comprising Boosting Polypeptide And Starch Degrading Enzyme And Uses Thereof - The present invention provides a composition comprising a polypeptide comprising or consisting of an X46 domain and further a starch degrading enzyme and uses of such composition. The polypeptide comprising or consisting of an X46 domain can boost the activity of a starch-degrading enzyme. | 2012-10-04 |
20120252087 | Bipolar Flyback Power Supply - A device, system and method for treating biological cells includes a voltage source, a half-controlled bridge connected to the voltage source, and a load connected across the half-controlled bridge. The half-controlled bridge includes a first switch, a second switch, a first diode and a second diode. The load includes an inductor connected in parallel with a cell or chamber. A controller is connected to the first and second switches and operates the first switch and the second switch to selectively generate one or more bipolar pulses, wherein each bipolar pulse comprises a positive polarity voltage pulse and a negative polarity voltage pulse with a negligible delay between the positive polarity voltage pulse and the negative polarity voltage pulse. | 2012-10-04 |
20120252088 | FLOATING MAGNET PROBE FOR CELL ISOLATION - A cell isolation device with an inner freely floating magnetic probe to capture and collect biological cells, such as circulating tumor cells (CTCs), during immunomagnetic incubation provides a highly efficient, low cost method to collect target cells at a single cell level. A special membrane filter may be placed above a wash well to enable separation of collected cells from free magnetic beads to yield high purity cells enabling accurate cell count. The novel approach provides a faster turn-around to separate target cells from blood, marrow or other samples with efficient removal of free magnetic beads. Cancel cell spiking experiments show a recovery rate of greater than 85%. | 2012-10-04 |
20120252089 | CYTOCOMPATIBLE ALGINATE GELS - The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy. | 2012-10-04 |
20120252090 | HEAT RESISTANT BIOACTIVE COMPOSITION - A process for stabilizing a bioactive composition includes forming hydrogel matrix pores around protein molecules and reducing a water content within the hydrogel matrix pores while keeping the protein molecules biologically active. | 2012-10-04 |
20120252091 | LIGAND FUNCTIONAL SUBSTRATES - A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials. | 2012-10-04 |
20120252092 | CLOSTRIDIUM HISTOLYTICUM RECOMBINANT COLLAGENASES AND METHOD FOR THE MANUFACTURE THEREOF - The present invention relates to the production of recombinant collagenases, and in particular describes a method for the production of recombinant | 2012-10-04 |
20120252093 | YARROWIA ESTERASE/LIPASE PROMOTER REGIONS FOR GENE EXPRESSION IN YEAST - Promoter regions associated with the | 2012-10-04 |