40th week of 2014 patent applcation highlights part 66 |
Patent application number | Title | Published |
20140296435 | PHARMACEUTICAL COMPOSITION OF CHELATING COMPLEX MICELLES - This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier. | 2014-10-02 |
20140296436 | CYCLOOLEFIN POLYMER COMPOUND AND METHOD OF PREPARING THE SAME - This invention relates to a cycloolefin copolymer, which is prepared via ring-opening metathesis polymerization using, as monomers, dicyclopentadiene obtained by chemically bonding two cyclopentadiene molecules using a Diels-Alder reaction and tricyclopentadiene obtained by chemically bonding three cyclopentadiene molecules using a Diels-Alder reaction, in which the cyclopentadiene is a C5-fraction of naphtha cracking, and to a method of preparing the same. This copolymer is a non-crystalline transparent resin and is useful for a variety of end uses. | 2014-10-02 |
20140296437 | Vinyl Polymer Powder, Curable Resin Composition and Cured Product - A vinyl polymer powder, a curable resin composition containing the vinyl polymer powder and a curable resin, and a cured product obtained by curing the curable resin composition are provided. The vinyl polymer powder contains a vinyl polymer of which the glass transition temperature is 120° C. or higher and the mass average molecular weight is 100,000 or more, has excellent dispersibility in the curable resin composition, and rapidly turns the curable resin composition into a gel state by heating at a predetermined temperature in a short time. Further, the vinyl polymer powder decreases the linear expansion coefficient of the obtained cured product, and improves the crack resistance. | 2014-10-02 |
20140296438 | ULTRA-HIGH MOLECULAR WEIGHT POLY(VINYLIDENE FLUORIDE) - The invention relates to a polyvinylidene fluoride polymer having an ultra-high molecular weight, and unexpected physical properties. The ultra-high molecular weight polymer is clear, has a lower melting point, reduced crystallinity, excellent impact resistance, and a high elongation at the yield point. The ultra-high molecular weight polyvinylidene fluoride can be alone, or blended with other polymers, in final applications and articles. | 2014-10-02 |
20140296439 | MODIFIED RUBBER MASTERBATCH, AND RUBBER COMPOSITION AND VULCANIZED RUBBER PRODUCED THEREFROM, AND THE PREPARATION PROCESSES FOR THEM - The present application relates to a modified rubber masterbatch and preparation method thereof, rubber composition prepared therewith and vulcanized rubber and preparation method thereof. The modified rubber component comprises uncrosslinked rubber and rubber particles having crosslinked structure dispersed therein, wherein the rubber particles having crosslinked structure are synthetic rubber particles and/or natural rubber particles, have an average particle size of 20-500 nm and a gel content of 60% by weight or higher, and wherein the uncrosslinked rubber is styrene-butadiene rubber. The weight ratio of the rubber particles having crosslinked structure to the uncrosslinked rubber is greater than 20:80 and less than or equal to 80:20. The rubber composition comprises a blend of modified rubber component and base rubber, in which the modified rubber masterbatch is present in an amount of 1 to 70 parts by weight, relative to per 100 parts by weight of the base rubber. The vulcanized rubber of the rubber composition has not only low rolling resistance and excellent wet skid resistance, but also excellent wear resistance, and thus can be used for producing high performance tread rubber. | 2014-10-02 |
20140296440 | IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY - The present invention relates to ionic silicone hydrogel polymers displaying improved thermal stability. More specifically, the present invention relates to a polymer formed from reactive components comprising at least one silicone component and at least one ionic component comprising at least one anionic group. The polymers of the present invention display good thermal stability and desirable protein uptake. | 2014-10-02 |
20140296441 | LACTAMIC POLYMER CONTAINING AN ACETOACETATE MOIETY - The invention provides lactamic polymers comprising an acetoacetate moiety. The lactamic polymers may be readily functionalized and the functionalized lactamic polymers may be further derivatized to provide a wide variety of useful polymers having desirable chemical and physical properties. The lactamic polymers of the invention may be employed in a wide variety of compositions. (A); (B) wherein R | 2014-10-02 |
20140296442 | ANTIBACTERIAL POLYMERS AND METHOD FOR OBTAINING THE SAME - The invention relates to polymers selected from among polypropylene (PP), polycarbonate (PC), acrylonitrile-butadiene-styrene (ABS), polyvinylchloride (PVC) and polyethylene terephthalate (PET), nylon and polystyrene, having antibacterial properties, wherein the antibacterial effect is obtained by adding a zinc salt selected from among: zinc PCA, zinc oxide, zinc hydroxide, zinc pyrrolidone or zinc pyrithione during the process of polymerization of the monomers. The antibacterial polymers are used to prepare products intended to enter into contact with the skin. | 2014-10-02 |
20140296443 | ACRYLIC ADHESIVE COMPOSITION AND POLARIZER FILM USING THE SAME - An adhesive composition includes an acrylic copolymer having at least one alkyl group, at least one hydroxyl group, and at least one furyl based group; and a curing agent. | 2014-10-02 |
20140296444 | MONOMERS AND POLYMERS DERIVED FROM NATURAL PHENOLS - Monomers, polymers and copolymers are provided that incorporate at least one naturally occurring phenolic compound, such as a plant phenol. | 2014-10-02 |
20140296445 | Method For Producing Polydienes And Polydiene Copolymers With Reduced Cold Flow - A method for preparing a coupled polymer, the method comprising the steps of: (i) polymerizing monomers to form a reactive polymer, and (ii) reacting the reactive polymer with a glycidic ester. | 2014-10-02 |
20140296446 | Modifying Polymeric Materials By Amines - This invention relates to the modification of polymeric materials containing reactive carbon-to-carbon unsaturation and to amines, including aziridines, which are used in such modification. A polymeric material containing carbon-to-carbon bonds can be modified by crosslinking or to make it susceptible to crosslinking. | 2014-10-02 |
20140296447 | Epoxy Resins With High Thermal Stability and Toughness - Epoxy resin compositions contain (i) a potyepoxide resin; (ii) a benzofuran diol component, a benzofuran di-epoxide component, or a mixture thereof; and (iii) a curing agent, which upon curing, provides a cured resin exhibiting improved chemical and physical characteristics. The epoxy resin composition may also contain a toughening agent to further enhance the cured resin's physical characteristics. | 2014-10-02 |
20140296448 | METHOD FOR PRODUCING POLYMER, DEVICE FOR PRODUCING POLYMER, DEVICE FOR PRODUCING COMPLEX, AND POLYMER PRODUCT - To pvodie a method for producing a polymer, which contains continuously supplying and bringing at least a ring-opening polymerizable monomer and a compressive fluid into contact with each other, to thereby allow the ring-opening polymerizable monomer to carry out ring-opening polymerization to continuously generate a polymer. | 2014-10-02 |
20140296449 | METHODS FOR PREPARING POLYMERS HAVING LOW RESIDUAL MONOMER CONTENT - Methods are provided for preparing polymer mixtures having low residual monomer content. The methods comprise mixing the at least two polymers in a solvent to form a polymeric mixture, the polymeric mixture comprising at least one residual monomer; and adding an antisolvent to the polymeric mixture so as to separate the at least two polymers from the polymeric mixture, where the residual monomer is soluble in the antisolvent. In some embodiments, methods are provided for preparing at least two polymers having low residual monomer content, the methods comprise adding an antisolvent to a mixture of at least two polymers dissolved in a solvent so as to precipitate the at least two polymers from the solvent and anti-solvent. The methods provided avoid steps in dry blending of polymers and produces polymer blends that have low residual monomer content. | 2014-10-02 |
20140296450 | SOLVENT-FREE CROSSLINKED POLYROTAXANE MATERIAL AND PROCESS FOR PRODUCTION OF SAME - A material comprising crosslinked polyrotaxanes which exhibits desired viscoelasticity, particularly stress-strain characteristics with a wide low-stress region, in spite of being free from solvent; and a process for production of the same. The material comprises a first polyrotaxane bearing first cyclic molecules and a second polyrotaxane bearing second cyclic molecules, and the first and second polyrotaxanes are crosslinked via the first and second cyclic molecules. The material is free from solvent and exhibits a stress of 2.0 MPa or below at 50% strain. | 2014-10-02 |
20140296451 | CHELATING COMPLEX MICELLES DRUG CARRIER - This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier. | 2014-10-02 |
20140296452 | HALOGEN-FREE, NONFLAMMABLE AND HIGH GLASS TRANSITION TEMPERATURE PHENOLIC RESIN-BASED CURING AGENT AND PROCESS FOR PRODUCING THE SAME - A phenolic-type phosphorous curing agent works by grafting a phosphorous compound onto a benzene ring to substitute hydrogen atoms and is halogen-free and nonflammable; when acting with and curing an epoxy resin, the curing agent helps to form a higher crosslink density and excellent heat tolerance to let the epoxy resin suitable for use in making PCB's insulating layer or semiconductor packaging as well as to endow the PCB's insulating layer or semiconductor packaging provided with excellent flame retardance and high glass transition temperature (Tg). | 2014-10-02 |
20140296453 | Catalyst Compositions for the Polymerization of Olefins - Catalyst compositions containing N,N-bis[2-hydroxidebenzyl]amine transition metal compounds are disclosed. Methods for making these transition metal compounds and for using such compounds in catalyst compositions for the polymerization of olefins also are provided. | 2014-10-02 |
20140296454 | CATALYST SYSTEM FOR THE PRODUCTION OF ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE - The invention relates to a catalyst system for the production of ultrahigh molecular weight polyethylene comprising I. a solid reaction product obtained by reaction of: (a) a hydrocarbon solution comprising (1) an organic oxygen containing magnesium compound or a halogen containing magnesium compound and (2) an organic oxygen containing titanium compound and (b) a mixture comprising a metal compound having the formula MeR | 2014-10-02 |
20140296455 | MULTINUCLEAR METALLOCENE CATALYST COMPOUND FOR OLEFIN POLYMERISATION AND COPOLYMERISATION AND METHOD FOR MAKING THEREOF - The invention relates to a multinuclear metallocene catalyst compound according to Formula (1), wherein Y and Y′ are the same or different and independently selected from the group consisting of C | 2014-10-02 |
20140296456 | Catalyst Systems for Production of Alpha Olefin Oligomers and Polymers - Catalyst compositions containing N,N-bis[2-hydroxidebenzyl]amine transition metal compounds are disclosed. Methods for making these transition metal compounds and for using such compounds in catalyst compositions for the polymerization or oligomerization of alpha olefins also are provided. | 2014-10-02 |
20140296457 | CATALYST PRECURSOR AND CATALYST FOR THE POLYMERISATION OF ETHYLENE - The invention is directed to a catalyst precursor for an ethylene polymerization catalyst comprising a porous inogranic support material carrying a chromium salt and an aluminium chelate. The aluminium chelate is aluminium di(C | 2014-10-02 |
20140296458 | TITANIUM-CATALYST SYSTEM COMPRISING SUBSTITUTED CYCLOPENTADIENYL, GUANIDINE AND DIENE LIGANDS - The invention relates to a catalyst system for the polymerization of olefins comprising a metal complex of formula CyLMD and an activating cocatalyst, wherein M is titanium, Cy is a cyclopentadienyl-type ligand, D is a diene, L is a guanidinate-containing ligand of the formula (I) wherein each A is independently selected from nitrogen or phosphorous and R, R | 2014-10-02 |
20140296459 | METHOD FOR PRODUCING CONJUGATED DIENE-BASED POLYMER - Disclosed is a method for producing a conjugated diene-based polymer capable of affording a polymer composition useful as a material for tires excellent in fuel economy. Specifically, there is disclosed a method comprising polymerizing monomer components comprising a conjugated diene compound and an aromatic vinyl compound using an alkali metal-based polymerization initiator in the presence of a hydrocarbon solvent and an ether compound represented by the following formula (1), wherein R represents an alkyl group having 1 to 8 carbon atoms. | 2014-10-02 |
20140296460 | CATALYST SYSTEM FOR HETEROGENOUS CATALYSIS OF AN ISOBUTYLENE POLYMERIZATION REACTION - A method for preparing a catalyst system for heterogenous catalysis of an isobutylene polymerization reaction includes the steps of forming an alumina support in which the alumina support has pores formed therein, and reacting BF | 2014-10-02 |
20140296461 | Aromatic Vinyl Copolymer, Method for Preparing the Same, and Molded Article Including the Same - An aromatic vinyl copolymer can exhibit excellent heat resistance and/or transparency and is a copolymer of a monomer mixture, which includes: an exo-methylene butyrolactone compound represented by Formula 1; an aromatic vinyl compound; and a vinyl cyanide compound. | 2014-10-02 |
20140296462 | DEGRADABLE POLYCATIONS DERIVED FROM AMINO ACID VINYL ESTERS - Described herein are the synthesis and polymerization of a series of N-Boc-protected amino acid vinyl ester (BAAVE) monomers. Homopolymers and heteropolymers containing the monomers are described, particularly heteropolymers with vinyl ester monomers such as vinyl acetate. Deprotection can be used to produce hydrophilic and hydrophobic polymers that are particular useful in biological applications such as cellular delivery of biological materials. | 2014-10-02 |
20140296463 | POLYMERS DERIVED FROM ITACONIC ACID - This invention relates to polymers containing structural units derived from itaconic acid which are useful, including uses as binders for fiberglass. | 2014-10-02 |
20140296464 | CHROMATOGRAPHY MEDIUM - The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same in chromatography, such as the isolation of recombinant proteins, monoclonal antibodies, viral vaccines and plasmid DNA. The invention further provides for the use of the chromatographic medium in a simulated moving bed system. | 2014-10-02 |
20140296465 | POLYACRYLIC ACID-BASED WATER-ABSORBING RESIN POWDER AND METHOD FOR PRODUCING THE SAME - A method for producing a polyacrylic water-absorbent resin powder includes the steps of: producing an acrylic monomer solution in which gas is dissolved and/or dispersed; polymerizing the monomer solution in the absence of a surface active agent or in the presence of not more than 300 ppm of a surface active agent; during or after polymerizing, fragmenting the resulting hydrated gel crosslinked polymer; and drying the fragmented hydrated gel crosslinked polymer, the gas being dissolved and/or dispersed in the monomer solution by (a) applying pressure to the acrylic monomer solution and the gas; (b) creating swirling flows of the acrylic monomer solution and the gas; or (c) introducing the gas with the acrylic monomer solution via fine holes. The production method efficiently produces a water-absorbent resin having an excellent water-absorption rate without deteriorating a liquid-absorbent property of a sanitary product or the like. | 2014-10-02 |
20140296466 | Method for Producing Bio-Based Homoserine Lactone and Bio-Based Organic Acid from O-Acyl Homoserine Produced by Microorganisms - The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources. | 2014-10-02 |
20140296467 | Iron(II) Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts - A composition is capable of curing via condensation reaction. The composition uses a new condensation reaction catalyst. The new condensation reaction catalyst is used to replace conventional tin catalysts. The composition can react to form a gum, gel, rubber, or resin. | 2014-10-02 |
20140296468 | Hydrosilylation Reaction Catalysts and Curable Compositions and Methods for Their Preparation and Use - A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains an iron-organosilicon ligand complex that can be prepared by reacting an iron carbonyl compound and an organosilicon ligand. | 2014-10-02 |
20140296469 | CONTINUOUS PRODUCTION METHOD FOR POLYCARBONATE-POLYORGANOSILOXANE COPOLYMER - The present invention provides a method for producing a polycarbonate-polyorganosiloxane copolymer economically and stably, in particular, the present invention is concerned with a method for continuous production of a polycarbonate-polyorganosiloxane copolymer including (A) a step of withdrawing a polymerization reaction solution obtained by polymerizing a dihydric phenol compound, a carbonate precursor, and a polyorganosiloxane in the presence of an alkaline compound aqueous solution and a water-insoluble organic solvent continuously or intermittently from a reactor; (B) a step of separating the polymerization reaction solution withdrawn in the step (A) into an aqueous phase and a water-insoluble organic solvent phase; and (C) a step of after washing the water-insoluble organic solvent phase separated in the step (B) with an acidic aqueous solution, separating the resultant into an aqueous phase and a water-insoluble organic solvent phase, wherein the aqueous phase separated in the step (C) is extracted with a water-insoluble organic solvent, the content of the polycarbonate-polyorganosiloxane copolymer in the obtained extract is controlled to not more than 2% by mass, and a part or the whole of the extract is reused for the step (A). | 2014-10-02 |
20140296470 | RESIN MATERIAL AND PROTECTIVE FILM - Disclosed is a resin material which is formed by polymerization of an acrylic resin containing a side chain having a hydroxyl group and a side chain having a fluorine atom, at least one kind of polyol having a weight-average molecular weight from 300 to 5000 and selected from compounds represented by the following Formula (A), and an isocyanate. | 2014-10-02 |
20140296471 | DIOL COMPOSITION AND POLYESTER - A diol composition includes a diol as a major component and has an electrical conductivity of 0.6 to 30 mS/m. | 2014-10-02 |
20140296472 | PROCESS FOR THE PREPARATION OF POLYAMIDES - The disclosures herein relate to a process for making polyamides from stoichiometrically imbalanced mixtures. This process includes the production and subsequent use of solidified stoichiometrically imbalanced components comprising mixtures of diacids and diamines. This stoichiometric imbalance is defined by a component molar ratio equal to moles of dicarboxylic acid units divided by moles of diamine units; and wherein this molar ratio is different from unity. This process comprises steps of: a) forming an acid-rich solidified first component in a dry or moisture containing state by; b) contacting at least a dicarboxylic acid with at least a diamine in a molar ratio of greater than 1:1; c) forming an amine-rich solidified second component in a dry or moisture containing state by; d) contacting at least a dicarboxylic acid with at least a diamine in a molar ratio of less than 1:1; e) contacting the acid-rich first component with the amine-rich second component in a molten state or a solution state and f) forming a first composition having a composition molar ratio g) such that a total dicarboxylic acid content and a total diamine content, supplied by said first and second components, is from about 0.95 to about 1.05; h) heating the first composition with agitation in the molten state and under pressure to a sufficiently high temperature for a polyamidation reaction to and subsequently, i) forming a second composition comprising a polyamide. | 2014-10-02 |
20140296473 | POLYCARBONATE COPOLYMER AND METHOD OF PRODUCING THE SAME - The problem to be solved by the present invention is to provide a polycarbonate copolymer containing a plant-derived raw material, which is excellent in the mechanical strength and heat-resistant and assured of small refractive index, large Abbe number, small birefringence and excellent transparency. The present invention provides a polycarbonate copolymer containing a constitutional unit derived from a dihydroxy compound represented by the following formula (1) and a constitutional unit derived from an alicyclic dihydroxy compound, wherein the Abbe number is 50 or more and the 5% thermal reduction temperature is 340° C. or more; and a method of producing this polycarbonate copolymer by reacting a dihydroxy compound represented by the following formula (1) and an alicyclic hydroxy compound with a carbonic acid diester in the presence of a polymerization catalyst. | 2014-10-02 |
20140296474 | PREPARATION OF POLY(ALKYLENE CARBONATE) CONTAINING CROSS-LINKED HIGH MOLECULAR WEIGHT CHAINS - Provided is preparation of poly(alkylene carbonate) through alternating copolymerization of carbon dioxide and epoxide. According to the disclosure, by introducing a diepoxide compound to alternating copolymerization of carbon dioxide and epoxide compound using a metal(III) prepared with salen-type ligands containing quaternary ammonium salt as a catalyst, some of the polymer chains may be cross-linked to thus increase an average molecular weight of the copolymer and extend a distribution of molecular weight. A resin prepared according to this method may have high mechanical strength and rheological advantages. | 2014-10-02 |
20140296475 | METHOD FOR PREPARING PHYSIOLOGICALLY ACTIVE POLYPEPTIDE COMPLEX - A method for preparing a conjugate of a physiologically active polypeptide and a non-peptide polymer by linking physiologically active polypeptide with non-peptide polymer through a covalent bond using an organic solvent is provided. A method for preparing a physiologically active polypeptide complex by linking the conjugate with a carrier is provided. The complex shows improved in vivo duration and stability of the physiologically active polypeptide. The method can prepare the conjugate at a lower production cost, and the resulting conjugate shows an extension of in vivo activity at a relatively high level and significantly increase in the blood half-life. | 2014-10-02 |
20140296476 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES - The present invention provides methods and compositions that permit controlled and prolonged drug release in vivo. The compounds are either prodrugs with tunable rates of release, or conjugates of the drug with macromolecules which exhibit tunable controlled rates of release. | 2014-10-02 |
20140296477 | ANTAGONIST PEPTIDE OF THE BOND BETWEEN CD47 AND A PROTEIN BELONGING TO THE THROMBOSPONDIN FAMILY - Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments. | 2014-10-02 |
20140296478 | METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND - The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage. The coupling reaction may be performed in solution, such as an aqueous solution. Furthermore, described is a method for selecting a candidate drug compound comprising providing a library of the compounds and determining the binding of a target molecule to the compounds. | 2014-10-02 |
20140296479 | D-APTIDE AND RETRO-INVERSO APTIDE WITH MAINTAINED TARGET AFFINITY AND IMPROVED STABILITY - The present invention is characterized by a D-Aptamer-Like Peptide (D-Aptide) or retro-inverso Aptide which specifically binds to a target comprising: (a) a structure stabilizing region comprising parallel, antiparallel or parallel and antiparallel D-amino acid strands with interstrand noncovalent bonds; and (b) a target binding region I and a target binding region II comprising randomly selected n and m D-amino acids, respectively, and coupled to both ends of the structure stabilizing region. The D-Aptide or retro-inverso Aptide has the sequence of the same or opposite direction to L-Aptide, wherein the stability to proteases is improved while maintaining the affinity to a target compared with L-Aptide. The D-Aptide of the present invention has substantially the same target affinity and a remarkably improved stability compared with L-Aptide which is different from a general technical knowledge. | 2014-10-02 |
20140296480 | PEPTIDE SECRETED BY LACTOBACILLUS PLANTARUM WITH IMMUNOMODULATING FUNCTION - Among the fewer than 10 proteins primarily secreted by the species | 2014-10-02 |
20140296481 | Diagnosis and Monitoring of Renal Failure Using Peptide Biomarkers - Methods for the determination of renal failure, especially chronic renal failure and acute kidney injury, by measurement of peptide or protein biomarkers are described. The methods are useful to determine stages of renal failure, especially the early stages such as stage 1, 2, and 3 of chronic renal failure and stages R and I of acute kidney injury. Furthermore there are described peptides and test kits used in the invention. The described methods are intended to replace or complement the measurement of creatinine and/or cystatin C and/or NGAL for diagnosis of renal failure. | 2014-10-02 |
20140296482 | METHOD TO SCREEN FOR SELECTIVE PEPTIDES THAT INHIBIT THE BIOLOGICAL ACTIVITY OF CALCINEURIN - The invention relates to the biotechnology sector involving the area of human health. More specifically, the invention is based on the surprising usefulness of peptides LxVPc1, c3 and c4 as efficient selective inhibitors of the calcineurin signalling pathway (CN)-NFAT and the phosphate activity of CN. Said compounds are useful immunosuppressors and serve as a base for the preparation of therapeutic compositions for the prophylactics and treatment of human diseases associated with T-lymphocyte activation, including, but not limited to, autoimmune diseases, inflammation and allergy or transplant rejections. In addition, said peptides and the associated biological and genetic material can form useful tools for the development of tests that can be used to find compounds that have a selective antagonist activity in relation to CN. | 2014-10-02 |
20140296483 | METHOD FOR REMOVING FMOC GROUP - The present invention relates to a method of removing an Fmoc group, including a step of mixing a compound represented by the formula (I): | 2014-10-02 |
20140296484 | Cyclin Based Inhibitors of CDK2 and CDK4 - Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation. | 2014-10-02 |
20140296485 | ANIONIC DISPLACER MOLECULES FOR HYDROPHOBIC DISPLACEMENT CHROMATOGRAPHY - A process for separating organic compounds from a mixture by reverse-phase displacement chromatography, including providing a hydrophobic stationary phase; applying to the hydrophobic stationary phase a mixture comprising organic compounds to be separated; displacing the organic compounds from the hydrophobic stationary phase by applying thereto an aqueous composition comprising a non-surface active hydrophobic anionic displacer molecule and about 10 wt % or less of an organic solvent; and collecting a plurality of fractions eluted from the hydrophobic stationary phase containing the separated organic compounds; in which the non-surface active hydrophobic anionic displacer molecule comprises a hydrophobic anion and a counterion, CI, having the general formula A or B, as defined in the disclosure: [CM][Cl]d [CM-R*—CM′][Cl]d A B. | 2014-10-02 |
20140296486 | NOVEL AAV'S AND USES THEREOF - The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same. | 2014-10-02 |
20140296487 | Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses - Modified human plasma polypeptides or Fc and uses thereof are provided. | 2014-10-02 |
20140296488 | ANTI-NOTCH NRR ANTIBODIES AND METHODS USING SAME - The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies. | 2014-10-02 |
20140296489 | Protein Production Method - Production of etanercept using perfusion methods achieves attractive yields of properly folded protein. Desired temperature, feed media, titers and percent correctly folded protein are disclosed. | 2014-10-02 |
20140296490 | HIGHLY GALACTOSYLATED ANTIBODIES - In one aspect, the disclosure relates to antibodies that are highly galactosylated, methods of production of these antibodies and methods of use of these antibodies. | 2014-10-02 |
20140296491 | GENERATING METAL ION BINDING PROTEINS - The present invention provides for a method for generating a metal ion binding protein, the method comprising a) integrating the amino acid sequence DDD into CDR1 of a light chain variable region of an antibody or fragment thereof; and b) combining the sequence of step a) with a heavy chain variable region of an antibody or fragment thereof; and c) isolating the protein. Also provided is the use of metal ion binding proteins generated by the method of the present invention for isolation and purification of proteins and for the reversible labeling of a target molecule. Also provided is a metal ion binding anti-CD8 protein. | 2014-10-02 |
20140296492 | HLA-RESTRICTED, PEPTIDE-SPECIFIC ANTIGEN BINDING PROTEINS - Antigen binding proteins with TCR-like paratopes, that is, with an antigen binding region specific for an HLA-A2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab′)2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the specificity of the antigen binding region for each peptide are also contemplated by the invention. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the invention. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function. | 2014-10-02 |
20140296493 | METHOD OF TREATING DEPRESSION USING A TNFa ANTIBODY - The invention describes methods of treating depression comprising administering a TNFα antibody, such as a human TNFα antibody. | 2014-10-02 |
20140296494 | PROTEIN EXPRESSION IN PLANTS - The present invention relates to protein expression in plants, particularly the large-scale production of recombinant polypeptides in whole | 2014-10-02 |
20140296495 | Sequential Hydrothermal Liquifaction (SEQHTL) for Extraction of Superior Bio-Oil and Other Organic Compounds from Oleaginous Biomass - Methods of producing bio-fuel and other high-value products from oleaginous biomass (e.g. algae biomass) are provided. The two-step methods use a first step of subcritical water extraction of the biomass at low temperatures to produce polysaccharides and other high value products of interest, followed by, ii) hydrothermal liquefaction of remaining solid biomass at high temperatures to produce bio-oil. | 2014-10-02 |
20140296496 | METHOD FOR EXTRACTING BROWN ALGAE POLYSACCHARIDE VIA MICROWAVE CHEMICAL PROCESS - This invention relates to an extraction process of brown algae polysaccharides in a field of pharmaceutical chemistry. This invention particularly discloses a process of extracting brown algae polysaccharides based on a microwave chemistry method and brown algae polysaccharides obtained by said process. The process of the invention comprises: 1) putting pulverized brown algae powder into a microwave reaction chamber, adding acid solution to conduct reaction; optionally concentrating the mixer, and then washing with organic solvent to remove excess acid; conducting grading alcohol precipitation after water extract to obtain mannuronic acid rich fragment (M rich) algin, fucoidan and/or laminaran respectively; and adding an alkali solution to the brown algae residue to conduct alkaline digestion, filtering the residue off, adjusting pH of the filtrate to neutral, conducting alcohol precipitation to obtain guluronic acid rich fragment (G rich) algin precipitates. The present invention has significant advantages like fast processing rate, high yield of polysaccharides, strong controllable polysaccharide degradation, using less organic acid and efficient recovery, small water consumption, low power consumption, etc., the active polysaccharides has high yield and content, better water-soluble, and good biological activities. | 2014-10-02 |
20140296497 | Method for Producing Myo-Inositol and Myo-Inositol Derivative - [Problem] To impart significantly improved myo-inositol producing capability, suitable for use in recombinant DNA techniques and synthetic biology methods, to a host microorganism that does not possess an endogenous myo-inositol biosynthesis pathway, such as | 2014-10-02 |
20140296498 | Tiacumicin Production - Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species | 2014-10-02 |
20140296499 | Novel Process for the Preparation of Rebaudioside D and Other Related Naturally Occurring Sweetners - A novel process for preparation of Rebaudioside D (RD), and other related naturally occurring sweeteners is provided. RD is a natural sweetening agent which can decrease the bitter aftertaste of steviol glycosides. The said process is suitable for commercial manufacturing by using readily available natural products and nontoxic reagents. | 2014-10-02 |
20140296500 | Methods and Compositions of Nucleic Acid Ligands for Detection of Clinical Analytes Related to Human Health - Specific DNA sequences for binding various clinically relevant analytes from the human body are described. Each of these sequences or their linear, two- and three-dimensional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linkage of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity and sensitivity in many instances. In addition, a FRET-based quantitative method is described for normalizing analyte data by assessing urine creatinine and urea levels. Finally, a method is described for removing creatinine or urea by size-exclusion chromatography prior to a FRET-based aptamer assay to avoid the denaturing effects of these compounds. | 2014-10-02 |
20140296501 | Aptamers and Diagnostic Methods for Detecting the EGF Receptor - The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. | 2014-10-02 |
20140296502 | ANTISENSE DESIGN - A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved antisense properties. The novel oligonucleotides are composed of at least one LNA selected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. The oligonucleotides comprising LNA may also include DNA and/or RNA nucleotides. | 2014-10-02 |
20140296503 | ISOLATED dsRNA MOLECULES AND METHODS OF USING SAME FOR SILENCING TARGET MOLECULES OF INTEREST - An isolated dsRNA molecule comprising an antisense RNA sequence for regulating a target gene of interest in a plant or a phytopathogen of the plant, wherein the dsRNA sequence is flanked by two complementary sites to an smRNA or smRNAs expressed in the plant and wherein the dsRNA molecule further comprises a helicase binding site positioned so as to allow unwinding of the strands of the isolated dsRNA molecule to single stranded RNA (ssRNA) and recruitment of an RNA-dependent RNA polymerase so as to amplify the dsRNA molecule in the plant cell and generate secondary siRNA products of the dsRNA sequence. | 2014-10-02 |
20140296504 | HEPATITIS B VIRAL VARIANTS WITH REDUCED SUSCEPTIBILITY TO NUCLEOSIDE ANALOGS AND USES THEREOF - The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus. | 2014-10-02 |
20140296505 | COMPOSITIONS AND METHODS FOR BACTERIAL PRODUCTION OF CHONDROITIN - The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial fermentation and post-fermentation sulfation. | 2014-10-02 |
20140296506 | GLUCOPYRANOSIDE COMPOUND - A compound of the formula: | 2014-10-02 |
20140296507 | Polymer Hydrogels and Methods of Preparation Thereof - The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications. | 2014-10-02 |
20140296508 | PROCESS FOR THE PREPARATION OF TRIVALENT IRON COMPLEXES WITH MONO-, DI- AND POLYSACCHARIDE SUGARDS - Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars, consisting of the activation of the sugar by oxidation with nascent bromine generated in situ by reaction between an alkaline or alkaline earth bromine and an alkaline hypochlorite, the complexation of the activated sugar in solution with a ferric salt dissolved in an aqueous solution, the purification of the resulting solution through ultrafiltration and finally the stabilization of the trivalent iron-sugar complex by heating at a temperature between 60° C. and 100° C. for a period between 1 and 4 hours at a pH between 9.0 and 11.0. | 2014-10-02 |
20140296509 | Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents - Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods. | 2014-10-02 |
20140296510 | Method for preparing ulipristal acetate and key intermediate thereof - A method as well as new intermediates for preparing Ulipristal acetate (a compound I) and a method for preparing the new intermediates are provided. The intermediate in a constitutional formula IV is conductive to reacting with methyl lithium or methyl Grignard reagent, a protective group is easy to be removed after a reaction, side reactions are few, a mid-term treatment is simple, the reagents used are cheap, costs are low and a yield is high, if a compound in a constitutional formula V is obtained by the reaction of a compound in a constitutional formula III and the intermediate in the constitutional formula IV, the yield of a two-step reaction is 75%, a purity is above 98%. | 2014-10-02 |
20140296511 | HALOGENATED COMPOUNDS FOR PHOTODYNAMIC THERAPY - Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications. | 2014-10-02 |
20140296512 | PROCESS FOR THE SYNTHESIS OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE COMPOUNDS, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE - Process for the synthesis of the compound of formula (I): | 2014-10-02 |
20140296513 | NOVEL THERAPEUTIC USE OF P75 RECEPTOR ANTAGONISTS - The present disclosure relates to the use of a p75 receptor antagonist or its pharmaceutically acceptable salts for the preparation of a medicament for use in the treatment and/or prevention of overactive bladder. | 2014-10-02 |
20140296514 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN - The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): | 2014-10-02 |
20140296515 | ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF - The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders. | 2014-10-02 |
20140296516 | MOLYBDENUM AND TUNGSTEN METAL COMPLEXES AND USE THEREOF AS PRECATALYSTS FOR OLEFIN METATHESIS - The invention relates to metal complexes of general formula (I) and to a method for the production thereof, in which M, R | 2014-10-02 |
20140296517 | L-Setastine Hydrochloride and Preparation Method Thereof - The present invention relates to the field of medicine, and disclosed are an L-setastine hydrochloride and a preparation method therefor. The compound of the present invention has the advantages of stronger histamine Hi receptor antagonism and small side effect; the yield of the preparation method is more than 80%, and the product purity is high. The present invention also provides an application of the compound as an H1 histamine receptor antagonist. | 2014-10-02 |
20140296518 | Colored Charged Silsesquioxanes - The present invention provides compounds of formula | 2014-10-02 |
20140296519 | 4-AMINOCARBAZOLE COMPOUND AND USE THEREOF - A 4-aminocarbazole compound represented by formula (1): | 2014-10-02 |
20140296520 | PROCESS FOR THE PREPARATION OF VALACYCLOVIR HYDROCHLORIDE - The present invention provides a process for the preparation of 2-[(2-amino-1,6-dihydro-6-oxo-9H-yl)]ethyl L-valine ester hydrochloride (valacyclovir hydrochloride) of formula I comprising deprotection of N-[(benzyloxy)carbonyl]-L-valine-2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, of formula II using 5% palladium on carbon as a catalyst and mineral acid in the presence of water, avoiding use of organic solvents under hydrogen pressure to yield valacyclovir hydrochloride having yield of ≧90% and purity of ≧99.5%, pharmaceutically acceptable grade. The valacyclovir hydrochloride obtained using the process of the present invention is valacyclovir hydrochloride polymorphic Form I. | 2014-10-02 |
20140296521 | COELENTERAZINE ANALOGS AND MANUFACTURING METHOD THEREOF - There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula ( | 2014-10-02 |
20140296522 | CATALYTIC CARBONYLATION CATALYSTS AND METHODS - In one aspect, the present invention provides catalysts for the carbonylation of heterocycles. The inventive catalysts feature metal-ligand complexes having cationic functional groups tethered to the ligand, wherein the tethered cationic groups are associated with anionic metal carbonyl species. The invention also provides methods of using the inventive catalysts to affect the ring opening carbonylation of epoxides. | 2014-10-02 |
20140296523 | Ionic Liquids, The Method For Preparing The Same And Method For Removing Acetylenes From Olefin Mixtures Using The Ionic Liquids - There are provided an ionic liquid having ether group(s) in which a copper(I) compound is included, a method for preparing the same, and a method for removing traces amounts of acetylene-based hydrocarbon compounds included in olefin by absorption or extraction using the same. When the disclosed solution is used, oxidation of Cu(I) to Cu(II) is prevented since CuX is stabilized by the ionic liquid. Thus, selective removal efficiency of acetylenic compounds is improved greatly while the removal performance is retained for a long period of time. Further, since the solution according to the present disclosure is applicable as an extractant as well as an absorbent, the associated operation is simple and apparatus cost can be decreased. | 2014-10-02 |
20140296524 | HALOGENATED COMPOUNDS FOR PHOTODYNAMIC THERAPY - Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications. | 2014-10-02 |
20140296525 | PROCESS FOR RECOVERY OF NALMEFENE HYDROCHLORIDE - The present invention relates to an improved process for recovery of nalmefene hydrochloride [17-(cyclopropylmethyl)-4,5- alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride] from an aqueous composition containing nalmefene and certain impurities. | 2014-10-02 |
20140296526 | NITROGEN CONTAINING COMPOUNDS AND THEIR USE - Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed. | 2014-10-02 |
20140296527 | PROCESSES FOR THE PREPARATION OF PYRROLIDINE INTERMEDIATES - The present invention relates to processes for the enantio-selective preparation of spyrrolidine derivatives useful in the manufacture of pesticidally active compounds, as well as to intermediates in the processes. The processes include those comprising | 2014-10-02 |
20140296528 | 4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS - The 4-aryl-1-(biarylmethylene)piperidine compounds are piperadine compounds having a biaryl substituent linked to the nitrogen atom of the piperidine ring by a methylene (—CH | 2014-10-02 |
20140296529 | BIS-QUINALDINE COMPOUND AND A PROCESS FOR PREPARING THE SAME - The present disclosure relates to a bis-quinaldine compound of formula I and a process for the same. | 2014-10-02 |
20140296530 | INDOLIZINONE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF - The present invention provides compounds of general formula A useful as potential phosphodiesterase3 (PDE3) inhibitory agents and a process for the preparation thereof. The derivatives of formula A can be employed as therapeutics in human and veterinary medicine, where they can be used, for example, for the treatment and prophylaxis of the following diseases: heart failure, dilated cardiomyopathy, platelet inhibitors, cancer and obstructive pulmonary diseases. | 2014-10-02 |
20140296531 | Novel semi-synthetic small molecules for the treatment parasitic disease - Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness. | 2014-10-02 |
20140296532 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA - The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided. | 2014-10-02 |
20140296533 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-CHLORO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps. | 2014-10-02 |
20140296534 | COMPOUNDS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS - The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. The compounds deriving from these precursors are useful in methods of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease by positron emission tomography (PET) as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents. Furthermore, the present invention also discloses the precursor compounds in crystalline form. | 2014-10-02 |