| 40th week of 2008 patent applcation highlights part 61 |
| Patent application number | Title | Published |
|---|
| 20080241848 | METHODS FOR PRENATAL DIAGNOSIS OF ANEUPLOIDY - Methods are disclosed for the automated prenatal genetic diagnosis of aneuploidy using an automated fluorescence microscope, conducted on samples of maternal blood that have been hybridized with FISH probes. | 2008-10-02 |
| 20080241849 | Methods and compositions for diagnosing epithelial cell cancer - Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx, the overexpression of a nucleic acid of KS1/4, or the overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx in non-primary tissue being correlated with metastases of epithelial cancers. | 2008-10-02 |
| 20080241850 | Method of Protein Measurement - The present invention relates to a technique of measuring a protein based on a degree of coloring in a liquid sample mixed with a protein measurement indicator. In the present invention, information reflecting creatinine concentration in the liquid sample is obtained, and then an influence quantity caused by creatinine to the protein concentration measurement is eliminated based on the information. | 2008-10-02 |
| 20080241851 | Cartilage intermediate layer protein 2 C1 and its use to differentiate osteoarthritis from rheumatoid arthritis and non-disease conditions - A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage intermediate layer protein 2(CILP-2) in body fluids and more specifically, measuring in the sample the concentration of the N-terminal part of CILP-2 (2C1) or fragments thereof. | 2008-10-02 |
| 20080241852 | Compositions, kits, and methods for identification, assessment, prevention, and therapy of endometriosis - The invention relates to newly discovered marker polypeptides associated with endometriosis. Compositions, kits, and methods for detecting, characterizing, preventing, and treating endometriosis are provided. | 2008-10-02 |
| 20080241853 | MICROTITER SPIN ARRAY - An improvement in heterogeneous immunoassays in microtiter plates to significantly reduce assay time, from as much as 50% up to 90% of what used to be typical assay times. The improvement involves the rotation of the liquid in a microtiter plate and during incubation times for antigen capture and during incubation times for sample labeling. This is accomplished through the insertion of fluted cylindrical stirrers in each well, and the use of a conventional, commercially available, microtiter vortexer. | 2008-10-02 |
| 20080241854 | KITS AND METHODS FOR EVALUATING HAIR - The invention relates to kits and methods for analyzing hair, particularly for determining the amount of damage to hair, including placing hair into a solution containing at least one metal ion so that an amount of the metal ion is attached to the hair, removing the hair from the solution, determining the amount of metal ion attached to the hair, and determining the amount of damage to the hair based upon the amount of metal ion attached to the hair. | 2008-10-02 |
| 20080241855 | Method for simultaneously detecting an antigen of, and an antibody against, an infectious microorganism - The invention relates to a method for detecting, in vitro, an infection with a microorganism, such as the hepatitis C virus, in a biological sample, by simultaneously detecting an antigen of this microorganism and the antibodies against this same antigen, and also to the reagents and kits implementing this method. | 2008-10-02 |
| 20080241856 | Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo - The disclosure provides a method of labeling of cellular glycans bearing azide groups via a fluorescent labeling technique based on Cu(I)-catalyzed [3+2]cycloaddition (click activation) of a probe comprising an alkynyl group. The method entails generating a fluorescent probe from a nonfluorescent precursor, 4-ethynyl-N-ethyl-1,8-naphthalimide, by Cu(I)-catalyzed [3+2]cycloaddition of the alkyne group of the probe with an azido-modified sugar. The disclosure further provides a method of incorporating an azido-containing fucose analog into glycoconjugates via the fucose salvage pathway. The disclosure provides a method of fluorescent visualization of fucosylated cells by flow cytometry when cells treated with 6-azidofucose are labeled with the click-activated fluorogenic probe or biotinylated alkyne. A method of visualizing the intracellular localization of fucosylated glycoconjugates by fluorescence microscopy is also disclosed. | 2008-10-02 |
| 20080241857 | Netrin receptors - The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry. | 2008-10-02 |
| 20080241858 | RAPID MICROBIAL DETECTION AND ANTIMICROBIAL SUSCEPTIBIILITY TESTING - A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms. | 2008-10-02 |
| 20080241859 | AGLYCO PRODUCTS AND METHODS OF USE - Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which are immunogenic epitopes responsible for recognition of antigens by the immune system are provided. These glycoconjugates are useful in prevention of influenza virus binding to cells, treatment of schizophrenia and diagnosing chronic viral disease associated with development of cancer. | 2008-10-02 |
| 20080241860 | METHODS AND APPARATUS TO RECOGNIZE NERVE INJURIES - Methods and apparatus are described to recognize nerve injuries, specifically brachial plexus injuries, and their severity, preferably of newborn children. To achieve an inexpensive and quick test, which can be executed without harming the patient, it is proposed to measure the motor neuron loss by measuring a biochemical marker, i.e. NSE or protein S100 in a body fluid. | 2008-10-02 |
| 20080241861 | Biological materials and methods useful in the diagnosis and treatment of diseases - The present invention relates to a method of making a β-form of a prion protein which preferably has more β-sheet than α-helix structure and is soluble in the absence of a denaturant and/or is non-aggregated and exhibits partial resistance to digestion with proteinase K. The invention also relates to use of the β-form in medicine, especially for raising antibodies useful in the treatment and/or diagnosis of prion diseases. The invention also relates to methods of screening for compounds which are capable of inhibiting and/or reversing the conversion of the native α-form of a prion protein to a β-form, and to uses of identified compounds in medicine. | 2008-10-02 |
| 20080241862 | PROPIONYL AND BUTYRYL LYSINE MODIFICATIONS IN PROTEINS - While the identification of acetylated lysine residues on proteins is well-known, the modification of lysine residues through propionylation and butyrylation is not very well understood. A method for the identification and mapping of propionylated and butyrylated lysine residues has been developed. Anti-acetyllysine antibody, normally used to affinity purify a protein mixture based on the presence of acetylated lysine, can also be used to affinity purity proteins having propionylated and butyrylated lysine residues due to the structural similarity. The method involves searching protein databases to locate mass spectrometry datasets for those proteins purified by anti-acetyllysine antibody. The located spectra are manually reviewed to identify those peptides having propionyllysine and butyryllysine residues. These identified peptides are synthesized, with the lysine modifications added at the appropriate positions. The synthesized proteins are then analyzed with mass spectrometry and the resultant spectra are compared to those located in the protein databases to confirm the location of the lysine modifications. | 2008-10-02 |
| 20080241863 | Biomarkers for liver diseases and method for using the same - Biomarkers for liver diseases and method for using the same are provided. For detecting liver cirrhosis and liver cancer, the biomarkers are selected from any one of the amino acid sequences with SEQ ID NO:1 to SEQ ID NO:24 or derivatives or fragments or variants or the combination thereof or the antibodies against the amino acid sequences. Then the biomarkers are further developed into detection kits, such that by detecting the existence of autoantibodies or autoantigens in screened specimens, liver diseases are detected with higher accuracy and sensitivity. | 2008-10-02 |
| 20080241864 | EIA for monitoring legionella pneumophila presence in water samples - A qualitative and quantitative EIA for detecting | 2008-10-02 |
| 20080241865 | VISIBLE TO NEAR-INFRARED LIGHT PROBE COMPRISING COMPLEX OF CYPRIDINA LUCIFERASE AND QUANTUM DOT - The invention relates to a bioactive substance labeled with | 2008-10-02 |
| 20080241866 | Systems and methods for enhancing fluorescent signals - Composition, systems, apparatus and methods of enhancing fluorescent signals in biochemical are described. Metal particle proximity to enzymes that produce fluorescent products provide enhanced fluorescence of the product and plasmon resonance of the metal particle. Multi-labeled nucleotides enhance signal production. Reflectance of illumination light and emitted fluorescence increase signal strength for a given illumination light. | 2008-10-02 |
| 20080241867 | Apparatuses and methods for determining protease activity - The present invention relates to compositions and an apparatuses for determining protease activity. The compositions of the invention contain a reporter protein fused to at least one protease cleavage sequence, and a linker for attaching the protease cleavage sequence to a solid support. Methods for determining protease activity and characterizing proteases are also provided. | 2008-10-02 |
| 20080241868 | Method for increasing light emission from a chemiluminescent reaction - Method for increasing the emission of light from a chemiluminescent reaction including luminol, a peroxidase enzyme, an oxidant and a mediator of electrons through the use of a hypernucleophilic acylation catalyst belonging to the class of 4-aminopyridines. It is also described the use in diagnostic assays of chemiluminescent substrates containing said catalysts. | 2008-10-02 |
| 20080241869 | Compositions and methods for ameliorating hyperlipidemia - The invention provides compositions and methods for treating hyperlipidemia by administering a Microsomal Triglyceride Transfer Protein (MTP) inhibitor in combination with a Liver Fatty Acid-Binding Protein (L-FABP) inhibitor, methods of preventing the development of hepatic steatosis, methods of identifying an agent useful for treating hyperlipidemia, and methods of screening for inhibitors of MTP and L-FABP activity. Also provided are pharmaceutical compositions comprising a MTP inhibitor and a L-FABP inhibitor. | 2008-10-02 |
| 20080241870 | Composition For Creating an Artificial Bone Marrow Like Environment and Use Thereof - The present invention is in the domain of cell biology and medicine and relates to composition and in vitro methods for creation of artificial bone-marrow like environment and uses thereof. | 2008-10-02 |
| 20080241871 | Luminescence measuring apparatus - The present invention provides a luminescence measuring method that can be accurately and quickly carried out while inhibiting a possible background associated with viable bacteria adhering to a nozzle or Adenosine Tri Phosphate remaining in the nozzle, and an apparatus for the method. The present invention uses a washing apparatus characterized by including a nozzle, a lysys solution, a luminescence reagent solution, and a detection section, as well as a relevant washing method and a relevant luminescence measuring method. To remove viable bacteria adhering to the nozzle, the nozzle is immersed in the lysys solution and then in the luminescence reagent solution. The detection section monitors luminescence occurring during a washing process. | 2008-10-02 |
| 20080241872 | METHODS OF MODULATING COLD SENSORY PERCEPTION - The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction. | 2008-10-02 |
| 20080241873 | MULTI-USE MULTIMODAL IMAGING CHELATES - Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester chains, and light harvesting moieties. By changing the chelating ion, phosphoester chain length and/or the light harvesting moiety different imaging techniques, such as MRI, CT, fluorescence and absorption, x-ray and NIR, may be employed to image the tissue cells. Additionally, the cyclen-based chelates may be conjugated to provide for site-specific delivery of the cyclen-based chelate to the desired tissue cells. The cyclen-based chelates may also be delivered to the tissue cells by attaching the cyclen-based to a polymeric delivery vehicle. Although these cyclen-based chelates have a wide variety of application, the preferred use is for imaging of cancer cells, such as brain cancer, for improving resection of a cancerous tissue. | 2008-10-02 |
| 20080241874 | Method and device for manipulating individual small objects - A method for individually moving small objects, such as cells, from one location to another as well as a device for implementing the method is disclosed. A small object such as a cell is isolated at some initial location and moved to some destination location by the movement of the small object through a succession of intermediate locations until the small object arrives at the destination location. Also disclosed are methods of manipulating cells made possible by the method and device of the present invention. | 2008-10-02 |
| 20080241875 | APPARATUS AND METHOD OF DETECTING MICROORGANISM OR MICRO-PARTICLE IN REAL TIME - An apparatus for detecting a microorganism or micro-particle in real time includes a collection module comprising a condensation element unit which condenses water particles in an atmosphere and forms a droplet to which a microorganism or micro-particle in the atmosphere adheres to, and a collection channel unit which gathers the droplet and generates a droplet stream and a sensing module including a counting module. The droplet stream is introduced to the sensing module, and the sensing module detects and counts the microorganism or micro-particle which is adhered to the introduced droplet stream. | 2008-10-02 |
| 20080241876 | Information notification sample processing system and methods of biological slide processing - A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing. | 2008-10-02 |
| 20080241877 | Immobilised Enzymes - The present invention relates to a method for immobilizing enzymes in a solid porous support, and to enzymes immobilized in solid porous supports. Specifically, the present invention uses a fluid containing the enzyme under high pressure (such as 25 to 50 Mpa) to immobilize the enzyme (such as CALB) on the porous support (such as silica). The resulting porous support contain more immobilized enzyme than would otherwise have been obtained by a process carried out at atmospheric pressures. | 2008-10-02 |
| 20080241878 | Method For Enzmatic Cross-Linking Of A Protein, Cross-Linked Protein Thus Obatained And Use Thereof - The present invention provides methods for enzymatic cross-linking of a protein comprising performing a reaction for enzymatic cross-linking of said protein in the presence of a phenolic saccharide, wherein said reaction comprises the step of forming protein-protein cross-links. The present invention further provides a cross-linked protein obtainable by a method according to the invention as well as a protein that is cross-linked by a phenolic saccharide and the use of such proteins in a foodstuff. The invention also provides a foodstuff comprising a cross-linked protein of the invention as well as the use of a phenolic saccharide as a cross-linking agent for proteins. | 2008-10-02 |
| 20080241879 | Microorganism and protease decomposing proteins recalcitrant to proteolysis - The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to | 2008-10-02 |
| 20080241880 | Methods and compositions for determination of glycated proteins - This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits for assaying for a glycated protein in a sample, using inter alia, an amadoriase. | 2008-10-02 |
| 20080241881 | MODIFIED CLOSTRIDIAL TOXINS WITH ENHANCED TRANSLOCATION CAPABILITIES AND ALTERED TARGETING ACTIVITY FOR CLOSTRIDIAL TOXIN TARGET CELLS - The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an altered target domain; polynucleotide molecules encoding such modified Clostridial toxins; and methods of producing such modified Clostridial toxins. | 2008-10-02 |
| 20080241882 | Methods and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides - The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes fro producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides. | 2008-10-02 |
| 20080241883 | Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells - Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described. | 2008-10-02 |
| 20080241884 | Fused Protein Composition - A fusion protein composition of an antibody Fc region which is useful as a medicament in which effector function is improved is desired. | 2008-10-02 |
| 20080241885 | PROCESS FOR PRODUCING CELLULASE - Various methods for the production of cellulase are disclosed. In one embodiment the method for producing cellulase includes contacting a culture comprising a sophorolipid producer and a cellulase producer with a substrate that is consumed by the sophorolipid producer. In addition, a microorganism culture made from a sophorolipid producer and a cellulase producer is disclosed. | 2008-10-02 |
| 20080241886 | Process For the Treatment of Methane Emissions - The invention relates generally to a system and method for the treatment of gaseous emissions comprising methane, and in one specific embodiment, to a system and method for the treatment of emissions through the use of methanotrophic microorganisms. Certain embodiments of the invention are particularly advantageous because they reduce environmentally-destructive methane emissions and produce harvestable end-products. | 2008-10-02 |
| 20080241887 | Polypeptides With Starch Debranching Activity - Polypeptides comprising a catalytic starch debranching domain and a starch binding domain are disclosed. The polypeptides comprising the starch binding domain have an improved functionality in raw starch degradation compared with same catalytic unit in same amount but without the starch binding domain. | 2008-10-02 |
| 20080241888 | Method for Producing Purine Nucleosides and Nucleotides by Fermentation Using Bacterium Belonging to the Genus Bacillus or Escherichia - Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5′-inosinic acid are provided which include using a bacterium belonging to the genus | 2008-10-02 |
| 20080241889 | METHODS AND COMPOSITIONS FOR SYNTHESIS OF NUCLEIC ACID MOLECULES USING MULTIPLE RECOGNITION SITES - The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. The invention also provides host cells comprising nucleic acid molecules of the invention or prepared according to the methods of the invention, and also provides kits comprising the compositions, host cells and nucleic acid molecules of the invention, which may be used to synthesize nucleic acid molecules according to the methods of the invention. | 2008-10-02 |
| 20080241890 | Pcr Process And Arrangement For Dna Amplification Using Dry Reagents - A PCR process for DNA amplification with thermocyclisation of the corresponding reagents is disclosed, in which total integration of all substances and process steps is achieved in a closed, single-use unit (so-called cartridge) in which the reagents are stored in a storage-stable form at room temperature. According to the process, the water-soluble reagents are covered by a water-insoluble medium, then the DNA to be amplified is supplied and the water-insoluble medium is eliminated, so that the water-soluble reagents are dissolved and PCR can start. In the corresponding arrangement, a test unit designed as a single-use produce (a so-called cartridge) has at least one micro-channel or micro-cavity for receiving a PCR reagent. The PCR reagents in the form of a mixture which can be dried at a negligible vapour pressure and forms a storage-stable substance substance at room temperature adhere to the walls of the micro-channel or micro-cavity and form a thin film covered by an insoluble medium. | 2008-10-02 |
| 20080241891 | Method for the Amplification and Detection of HBV DNA Using a Transcription Based Amplification - The present invention provides a method for the transcription based amplification of a target HBV nucleic acid sequence starting from HBV DNA optionally present in a sample, comprising the steps of, —incubating the sample, suspected to contain HBV, in an amplification buffer with one or more restriction enzymes capable of cleaving the HBV DNA at a selected restriction site, said restriction enzyme creating a defined 3′ end of said HBV DNA stand(s), a promoter-primer, said promoter-primer having a 5′ region comprising the sequence of a promoter recognized by a DNA-dependent RNA polymerase and a 3′ region complementary to the define 3′ end of the DNA strand, a second or reverse primer, having the opposite polarity of the promoter-primer and comprising the 5′ end of the said target sequence, and in case of HBV ssDNA as the target sequence, a restriction primer, maintaining the thus created reaction mixture under the appropriate conditions for a sufficient amount of time for a digestion by the restriction enzyme to take place, subjecting the sample thus obtained to a heat treatment at a temperature and time sufficient to inactivate the restriction enzyme and/or to render at least partially a double strand single stranded, adding the following reagents to the sample: an enzyme having RNA dependent DNA polymerase activity, and maintaining the thus created reaction mixture under the appropriate conditions to a sufficient amount of time for the amplification to take place. | 2008-10-02 |
| 20080241892 | Modified surfaces for immobilization of active molecules - Modified surfaces, substrates, and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide either non-reactive surfaces or low density reactive groups, preferably on an otherwise non-reactive surface, for use in different applications including single molecule analyses. | 2008-10-02 |
| 20080241893 | METHODS FOR AMPLIFYING TRICHOMONAS VAGINALIS-DERIVED NUCLEIC ACID - Oligonucleotides useful for determining the presence of | 2008-10-02 |
| 20080241894 | VECTOR CONSTRUCTS - Improved vector constructs useful in the expression of double-stranded RNA are provided. The constructs are particularly useful for expression of double-stranded RNA in vitro and in vivo. | 2008-10-02 |
| 20080241895 | N-Acetyl-(R,S)-beta-Amino Acid Acylase Gene - The present invention provides genes that encode the N-acetyl-(R,S)-β-amino acid acylases. The N-acetyl-(R,S)-β-amino acid acylases were isolated and purified from bacterial cells and the nucleotide sequences were determined. A host, such as | 2008-10-02 |
| 20080241896 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE HYDROXYMETHYL-SUBSTITUTED PHENYLALANINE - The present invention provides a production method of optically active hydroxymethyl-substituted phenylalanine, which includes reducing cyano-substituted benzylidene hydantoin (1) to give aminomethyl-substituted benzyl hydantoin (2) or a salt thereof, converting an amino group of the aminomethyl-substituted benzyl hydantoin (2) or a salt thereof to a hydroxyl group to give hydroxymethyl-substituted benzyl hydantoin (3), treating the hydroxymethyl-substituted benzyl hydantoin (3) with an enzyme to give D-hydroxymethyl-substituted phenylalanine (4 | 2008-10-02 |
| 20080241897 | Enzymatic Oil Interesterification - An improved process for enzymatic interesterification of oil containing a chelating agent with a base and a lipase. | 2008-10-02 |
| 20080241898 | Application of Glucose Transport Mutants For Production Of Aromatic Pathway Compounds - This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being phenotypically Pts | 2008-10-02 |
| 20080241899 | Poly (3-Hydroxyalkanoate) Block Copolymer Having Shape Memory Effect - Provided is a PHB block copolymer having orientation-induced rubber-elasticity and temperature-sensitive shape memory effects, comprising a plurality of 3-hydroxybutyrate (3HB) blocks as a repeating unit and a plurality of 3-hydroxyvalerate (3HV) blocks as a repeating unit, and optionally a hydroxy acid repeating group containing 6 or more carbon atoms. | 2008-10-02 |
| 20080241900 | HIGHLY ACTIVE XYLOSE REDUCTASE FROM NEUROSPORA CRASSA - A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in | 2008-10-02 |
| 20080241901 | Hybrid Enzymes - The present invention relates to a hybrid enzyme comprising at least one carbohydrate-binding module amino acid sequence and at least the catalytic module of a glucoamylase amino acid sequence. The invention also relates to the use of the hybrid enzyme in starch processing and especially ethanol production. | 2008-10-02 |
| 20080241902 | PRODUCTION OF BIODIESEL, CELLULOSIC SUGARS, AND PEPTIDES FROM THE SIMULTANEOUS ESTERIFICATION AND ALCOHOLYSIS/HYDROLYSIS OF OIL-CONTAINING MATERIALS WITH CELLULOSIC AND PEPTIDIC CONTENT - The present invention relates to a method for producing fatty acid alkyl esters as well as cellulosic simplified sugars, shortened protein polymers, amino acids, or combination thereof resulting from the simultaneous esterification and hydrolysis, alcoholysis, or both of algae and other oil containing materials containing free fatty acids (FFA), glycerides, or combination thereof as well as polysaccharides, cellulose, hemicellulose, lignocellulose, protein polymers, or combination thereof in presences of an alcohol and an acid catalyst. | 2008-10-02 |
| 20080241903 | In vivo site-sepecific incorporation of N-acetyl-galactosamine amino acids in eubacteria - Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars. | 2008-10-02 |
| 20080241904 | PROCESS FOR PRODUCING ISOMALTOSE AND USES THEREOF - A novel process for producing isomaltose and uses thereof and comprising the steps of contacting saccharides, which have a glucose polymerization degree of at least two and α-1,4 glucosidic linkage as a linkage at the non-reducing end, with an α-isomaltosylglucosaccharide-forming enzyme, in the presence or the absence of α-isomaltosyl-transferring enzyme to form a-isomaltosylglucosaccharides, which have a glucose polymerization degree of at least three, α-1,6 glucosidic linkage as a linkage at the non-reducing end, and α-1,4 glucosidic linkage as a linkage other than the non-reducing end, and/or to form cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1″3)-α-D-glucopyranosyl-(1→}; contacting the saccharides so formed with isomaltose-releasing enzyme to release isomaltose; and collecting the released isomaltose; and uses thereof. | 2008-10-02 |
| 20080241905 | Transgene Delivering Retrovirus Targeting Collagen Exposed At Site Of Tissue Injury - A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component. | 2008-10-02 |
| 20080241906 | Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same - The invention relates to a scleroprotein of an adeno-associated virus which contains at least one mutation. Said mutation causes the chromatographic properties to be modified. The invention also relates to the production of said scleroprotein and the use thereof. | 2008-10-02 |
| 20080241907 | Extracellular Bioreduction - A method for processing environmental or industrial samples to remove, reclaim or otherwise reduce the level of chemical species present in the sample that act as redox active species. The redox active species is kept in a waste chamber and is separated from an aqueous bacterial culture that is held in a culture chamber. The waste chamber and the culture chamber are separated by a porous membrane through which electron transfer can occur but through which the aqueous bacterial culture cannot pass. The redox active species substantially remains in the waste chamber and is in non-contact with the aqueous bacterial culture during the process of removal, reduction or reclamation. | 2008-10-02 |
| 20080241908 | Petroleum based processed detergent for dry cleaning and its use - The present invention provides compositions and methods for dry cleaning garments. The present invention provides a petroleum based processed detergent for dry cleaning and methods of use. The present invention provides methods of using the petroleum based processed detergent for dry cleaning wherein use of the detergent decreases the proliferation of bacteria and microbes in the detergent, and reduces the opposite pollution ratio of the detergent following a dry cleaning cycle. Additionally, the petroleum based processed detergent maintains a stable conductivity during use. | 2008-10-02 |
| 20080241909 | Microfluidic chips for pathogen detection - The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens. | 2008-10-02 |
| 20080241910 | Devices for pathogen detection - The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens. | 2008-10-02 |
| 20080241911 | Analyzer - A sample analyzer for analyzing a biological sample is disclosed that comprising: a measurement specimen preparation section for preparing a measurement specimen by using a reagent and the biological sample; a irradiator for irradiating the measurement specimen with a light; a first light receiving section for receiving a light from the measurement specimen and converting the received light into an electrical signal; a analysis section for analyzing the measurement specimen based on the electrical signal output by the first light receiving section; and a selection section for selecting an intensity of light to be irradiated by the irradiator, wherein the irradiator is configured to irradiate with a light of an intensity corresponding to the light intensity selected by the selection section. | 2008-10-02 |
| 20080241913 | CHROMATOGRAPHIC TEST DEVICE AND METHOD FOR DETECTING ANALYTE - The present invention provides a chromatographic test device, comprising a first blood cell separation member, a second blood cell separation member and a chromatographic carrier disposed in this order from the upstream side of the direction of development of a sample, wherein the first blood cell separation member is constituted so as to separate the blood cell components and the liquid components from each other based on a development speed; the second blood cell separation member is constituted so as to separate the blood cell components and the liquid components from each other based on filtration; and the chromatographic carrier carries a capturing substance being capable of binding specifically to the analyte. A method for detecting the analyte in the sample containing red blood cells and liquid components by using the chromatographic test device is also disclosed. | 2008-10-02 |
| 20080241914 | System for automatically performing separation or purification of biological materials - A system for automatically performing the operations of separating and purifying a variety of biological materials for processing nucleic acids or biological materials from biological samples using solid materials. A base plate, a carriage attachment frame assembly including a frame and a plurality of mounting units, a magnetic bar assembly including a frame, a base plate transport unit, a carriage attachment frame assembly transport unit, a magnetic bar transport unit, and a control unit are utilized. A predetermined number and a small amount of samples can be selectively processed in accordance with a user's needs. | 2008-10-02 |
| 20080241915 | DNA CLONING VECTOR PLASMIDS AND METHODS FOR THEIR USE - The present invention is a group of cloning vector plasmids for use in constructing DNA molecules, such as transgenes, for the purpose of gene expression or analysis of gene expression. The present invention is also a method for using the cloning vector plasmids in a variable series of cloning steps to produce a final transgene product. The plasmid cloning vectors are engineered to minimize the amount of manipulation of DNA fragment components by the end user of the vectors and the methods for their use. Transgenes produced using the invention may be used in a single organism, or in a variety of organisms including bacteria, yeast, mice, and other eukaryotes with little or no further modification. | 2008-10-02 |
| 20080241916 | Multiple Gene Expression For Engineering Novel Pathways And Hyperexpression Of Foreign Proteins in Plants - The present invention relates in part to a tobacco chloroplast transformation vector effective for stably transforming a tobacco plant to express a multi-gene operon. | 2008-10-02 |
| 20080241917 | Vector For Delivering Target Substance Into Nucleus or Cell - It is intended to provide a vector for delivering a target substance into a nucleus or a cell. This object is achieved by providing a vector for delivering a target substance into a nucleus or a cell which comprises a lipid membrane structure having a lipid membrane containing an anionic lipid such as phosphatidic acid, cardiolipin, etc. | 2008-10-02 |
| 20080241918 | Hemagglutinin polypeptides, and reagents and methods relating thereto - The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto. | 2008-10-02 |
| 20080241919 | Defined media for pluripotent stem cell culture - Stem cells, including mammalian, and particularly primate primordial stem cells (pPSCs) such as human embryonic stem cells (hESCs), hold great promise for restoring cell, tissue, and organ function. However, cultivation of stem cells, particularly undifferentiated hESCs, in serum-free, feeder-free, and conditioned-medium-free conditions remains crucial for large-scale, uniform production of pluripotent cells for cell-based therapies, as well as for controlling conditions for efficiently directing their lineage-specific differentiation. This instant invention is based on the discovery of the formulation of minimal essential components necessary for maintaining the long-term growth of pPSCs, particularly undifferentiated hESCs. Basic fibroblast growth factor (bFGF), insulin, ascorbic acid, and laminin were identified to be both sufficient and necessary for maintaining hESCs in a healthy self-renewing undifferentiated state capable of both prolonged propagation and then directed differentiation. Having discerned these minimal molecular requirements, conditions that would permit the substitution of poorly-characterized and unspecified biological additives and substrates were derived and optimized with entirely defined constituents, providing a “biologics”-free (i.e., animal-, feeder-, serum-, and conditioned-medium-free) system for the efficient long-term cultivation of pPSCs, particularly pluripotent hESCs. Such culture systems allow the derivation and large-scale production of stem cells such as pPSCs, particularly pluripotent hESCs, in optimal yet well-defined biologics-free culture conditions from which they can be efficiently directed towards a lineage-specific differentiated fate in vitro, and thus are important, for instance, in connection with clinical applications based on stem cell therapy and in drug discovery processes. | 2008-10-02 |
| 20080241920 | Method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on a synthetic tubular structure - A method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on at least one surface of a synthetic tubular structure to be used to make a human hybrid carotid graft is provided. The method includes arranging a plurality of human stem cells on the synthetic tubular structure to yield a hybrid stem cell/synthetic tubular structure and subjecting ex vivo, the hybrid stem cell/synthetic tubular structure to three dimensional dynamic conditions effective to promote differentiation of the one or more human stem cells into human coronary endothelial cells on the at least one surface. | 2008-10-02 |
| 20080241921 | Method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on a synthetic tubular structure - A method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on at least one surface of a synthetic tubular structure to be used to make a human hybrid coronary graft is provided. The method includes arranging a plurality of human stem cells on the synthetic tubular structure to yield a hybrid stem cell/synthetic tubular structure and subjecting ex vivo, the hybrid stem cell/synthetic tubular structure to three dimensional dynamic conditions effective to promote differentiation of the one or more human stem cells into human coronary endothelial cells on the at least one surface. | 2008-10-02 |
| 20080241922 | Use of Biocistronic DNA Constructs for Identifying Compounds that Inhibit IRES-Dependent Translation - The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection. | 2008-10-02 |
| 20080241923 | Humanized Anti-CCR2 Antibodies and Methods of Use Therefor - The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. | 2008-10-02 |
| 20080241924 | Antibody-Mediated Induction of Tumor Cell Death - This invention provides methods and reagents for inducing cell death in tumor cells. The invention provides said reagents relating to inducing tumor cell death that are antibodies to a specific target, L1CAM, and methods for using said antibodies for inducing cell death. Pharmaceutical compositions of the L1CAM antibodies for use in the practice of the methods of the invention are also disclosed. | 2008-10-02 |
| 20080241925 | Three-Dimensional Self Assembly in Suspension of Adherent Cells - Methods and vessels for three-dimensional self-assembly of cells in suspension. The methods and vessels involve pre-coating a cell culture vessel with an adhesion-inhibiting substance such as Pluronic prior to culturing a cell therein. | 2008-10-02 |
| 20080241926 | CELL ADHESION ON SURFACES OF VARYING TOPOGRAPHIES - Micro-topography of a surface influences cell adhesion and proliferation. To improve adhesion, polyelectrolyte multilayers (PEMs) are built on patterned support layers to increase surface wettability, thereby improving attachment and spreading of the cells. Physical parameters, such as pattern size and pitch, in part, regulate cell adhesion and proliferation. Varying the surface topography provides a method to influence cell attachment and proliferation for tissue engineering applications. | 2008-10-02 |
| 20080241927 | NOVEL GLYPHOSATE-N-ACETYLTRANSFERASE (GAT) GENES - Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate. | 2008-10-02 |
| 20080241928 | METHODS AND COMPOSITIONS FOR ACID PHOSPHATASE-1 GENE INHIBITION - The ACP1 *A allele provides a means for diagnosing susceptibility of a human subject to hyperlipidemia, especially hyperlipidemia associated with metabolic syndrome, a means for treating, or preventing the onset of, hyperlipidemia and metabolic syndrome, and a means for screening and identifying drugs suitable for use in treating or preventing hyperlipidemia, especially hyperlipidemia associated with metabolic syndrome. Diagnostic kits are also provided. | 2008-10-02 |
| 20080241929 | METHOD AND MEANS FOR PRODUCING HIGH TITER, SAFE, RECOMBINANT LENTIVIRUS VECTORS - Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters. | 2008-10-02 |
| 20080241930 | Paramyxoviridae Virus Preparations - This document involves methods and materials related to obtaining Paramyxoviridae virus preparations. | 2008-10-02 |
| 20080241931 | System For Expression of Genes In Plants - The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants. | 2008-10-02 |
| 20080241932 | Analyte detection via electrochemically generated reagent - Electrochemical devices, methods, and systems for detecting and quantifying analytes are disclosed. A chemical detection reagent is locally generated in a test solution by electrochemical reaction of a precursor compound caused to migrate into the test solution from a precursor solution separated from the test solution by a cell separator. This approach provides precise metering of the reagent, via the charge passed, and avoids the need to store a reagent solution that may be chemically unstable. In one embodiment, the starch concentration in a colloidal solution can be measured via spectroscopic detection of a blue complex formed by the interaction of starch with iodine produced, on demand, by electrochemical oxidation of iodide ion. The approach may also be used to characterize certain types of analytes. The invention is amenable to automation and is particularly useful for on-line monitoring of production processes, including the inclusion of feed back loop mechanisms for process control. | 2008-10-02 |
| 20080241933 | Biological Saw Sensor - Analysing fluid samples for target biological or chemical species comprising a detector unit with a body incorporating a SAW sensor ( | 2008-10-02 |
| 20080241934 | Methods for reducing complexity of a sample using small epitope antibodies - The present invention relates generally to methods for reducing the complexity of a sample. More specifically, the present invention relates to proteomics, the measurement of the protein levels in biological samples, and analysis of proteins in a sample using antibodies that recognize small epitopes. | 2008-10-02 |
| 20080241935 | Methods for pathogen detection - The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens. | 2008-10-02 |
| 20080241936 | Multianalyte Molecular Analysis Using Application-Specific Random Particle Arrays - The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample. | 2008-10-02 |
| 20080241937 | Sample analyzer and sample analyzing method - A sample analyzer and sample analyzing method perform following: a) mixing a sample with at least one of a first reagent and a second reagent, thereby preparing a measurement specimen; b) storing, in a memory, standard curve data corresponding to a reagent to be used in the step a) for preparing a measurement specimen; c) measuring the measurement specimen thereby obtaining measurement data; d) processing the measurement data based on the standard curve data, thereby obtaining an analysis result; and e) when the first reagent and the second reagent are of the same type, determining a reagent to be used for the measuring between the first reagent and the second reagent, based on information regarding standard curve data stored in the memory. | 2008-10-02 |
| 20080241938 | AUTOMATED SYNTHESIS OR SEQUENCING APPARATUS AND METHOD FOR MAKING AND USING SAME - An apparatus and method based on the apparatus is disclosed for automated single molecule or molecular assemblage detection via light irradiation and detection of transient FRET between a donor or acceptor bound to an immobilized single molecule or molecular assemblage and a corresponding acceptor or donor associated with, covalently bonded to, a reagent, where the donor or acceptor associated with the reagent is transiently in FRET proximity to the acceptor or donor associated with the immobilized molecule or molecular assemblage. | 2008-10-02 |
| 20080241939 | Sample analyzer, reagent aspirating method, and computer program product - The present invention is to present a sample analyzer which is capable of respond immediately when a need to perform analysis of multiple items arises. The sample analyzer | 2008-10-02 |
| 20080241940 | FECAL SAMPLING DEVICE AND METHOD - A specimen sampling device according to one embodiment has a first panel, a second panel, a sheet between the first and second panels for receiving the collected samples and a movable area creating metering apertures through which samples are received. The movable area is movable from a collection position, in which it is adjacent the sheet, to a test position, in which it is spaced away from the sheet. A method of obtaining a fecal sample is also disclosed. | 2008-10-02 |
| 20080241941 | REAGENT FOR MEASURING CLOTTING TIME AND METHOD FOR STABILIZING TISSUE FACTOR - The present invention provides a reagent for measuring clotting time comprising a nonionic surfactant, a nickel ion and a tissue factor. A method for stabilizing a tissue factor, and use of a nonionic surfactant and a nickel salt for stabilizing a tissue factor are also disclosed. | 2008-10-02 |
| 20080241942 | AIR-STABLE SUPPORTED LIPID BILAYER MEMBRANES - The present invention relates to methods for fabricating air-stable supported lipid bilayer membranes. In one embodiment, the present invention relates to methods of producing supported lipid bilayer membranes stabilized by sterol groups that are covalently tethered to a solid surface. In a further embodiment, the present invention relates to air-stable supported lipid bilayer membranes produced by the methods of the present invention. | 2008-10-02 |
| 20080241943 | Subnanomolar Precipitator of Thiophilic Metals - A fluorescent dye-doped crystalline assay is employed for selection and detection of thiophilic heavy metal ions. While comparable in analytical performance to known solution based methodologies, the formation of crystalline analytes provides for signal amplification, and consequently, a powerful platform whose analysis is directly amenable to high-throughput video capture systems. In a microcapillary format, this assay is capable of screening hundreds of samples per day for the presence of subnanomolar concentrations of Hg | 2008-10-02 |
| 20080241944 | METHOD OF MAKING GEL DROP PROTEIN BIOCHIPS - A method of making a gel drop protein chip by transferring proteins, which were obtained from a cellular lysate, partitioned using two-dimensional, protein fractionation, and mixed with a polymeric matrix solution containing acrylamide/bis and glycerol, to an array; a method of making a gel drop protein chip by transferring proteins, which were derivatized with N-hydroxysuccinimide ester of N-methacryloyl-6-aminocaproic acid (NHS monomer), and mixed with a polymeric matrix solution containing acrylamide/bis and glycerol, to an array; a gel drop protein chip containing proteins in a polymeric matrix solution containing acrylamide/bis glycerol; a method of using the gel drop protein chip to interrogate a sample; and a protein derivatized with the NHS monomer. | 2008-10-02 |
| 20080241945 | Peptide for differentiating osteoarthritis from rheumatoid arthritis and non-disease conditions - A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of a peptide comprising the 15 amino acid sequence (SEQ ID NO: 1) of the human cartilage intermediate layer protein 2. | 2008-10-02 |
| 20080241946 | Fibroblast growth factor (FGF23) and methods for use - The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides. | 2008-10-02 |
| 20080241947 | Intestinal folate transporter - Provided is an isolated and purified DNA molecule comprising the coding region of a PCFT cDNA. Also provided is a segment of the above DNA molecule, capable of serving as a primer for amplifying at least a portion of the DNA molecule. Additionally provided is a pair of the above segments that can be used together as forward and reverse PCR primers for amplifying at least a portion of the above DNA molecule. Further provided is an isolated and purified human PCFT protein. Also provided is a method of evaluating the ability of a human to undergo intestinal folate absorption. | 2008-10-02 |
| 20080241948 | Mycophenolate mofetil impurity - Provided is an impurity of mycophenolate mofetil, processes for its preparation and its use as a reference. | 2008-10-02 |
