39th week of 2010 patent applcation highlights part 62 |
Patent application number | Title | Published |
20100248249 | Methods for Assessing Cancer for Increased Sensitivity to 10-Propargyl-10-Deazaaminopterin by Assessing Egfr Levels - The present invention relates to a method for assessing the sensitivity of a patient's cancer to treatment with 10-propargyl-10-deazaminopterin and a method for selecting a patient for treatment of cancer with 10-propargyl-10-deazaminopterin, by determining the amount of a EGFR or other growth factor expressed by the cancer and comparing the amount with the amount of EGFR or other growth factor expressed by a reference cancer. | 2010-09-30 |
20100248250 | METHOD FOR PREPARING STOOL SAMPLE, SOLUTION FOR PREPARING STOOL SAMPLE, AND KIT FOR COLLECTING STOOL - Provided in the present invention are a method for preparing a stool sample without any need for complicated operations which is capable of efficiently recovering a nucleic acid or the like originating from mammalian cells, such as the cells exfoliated from the large intestine, in the stool; a solution for preparing a stool sample and a kit for stool collection which are used in the above method; and a method for recovering and analyzing the nucleic acid in stool using the stool sample prepared by the above method. More specifically, provided are a method for preparing a stool sample which is a method for preparing a stool sample in order to efficiently recover a nucleic acid from the stool sample, the method characterized in that the collected stool is mixed with a solution for preparing a stool sample which has a water-soluble organic solvent as an active ingredient; a solution for preparing a stool sample which is used in the method; a kit for collecting stool; a method for recovering a nucleic acid characterized by recovering a nucleic acid originating from indigenous enteric bacterium and a nucleic acid originating from an organism other than indigenous enteric bacterium at the same time from the stool sample prepared by the preparation method; and a method for analyzing a nucleic acid that analyzes the nucleic acid recovered by the method for recovering a nucleic acid. | 2010-09-30 |
20100248251 | Tissue Rejection - This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection. | 2010-09-30 |
20100248252 | METHODS FOR ANALYSIS OF MOLECULAR EVENTS - Methods and compositions are provided for detecting the presence of nucleic acid sequence variants in a subpopulation of nucleic acid molecules in a biological sample. These methods are particularly useful for identifying individuals with mutations indicative of cancer. | 2010-09-30 |
20100248253 | METHOD AND KIT FOR ASSESSING RISK OF GOUT AND HYPERURICEMIA - A method for assessing a risk of suffering from a gout of a subject is provided. The method includes steps of obtaining a nucleotide sample from the subject; determining a genetic polymorphism of one of a Urate transporter 1 (URAT1) gene and an alpha-kinase 1 (ALPK1) gene in the nucleotide sample, wherein the genetic polymorphism is associated with an occurrence of the gout; and comparing the genetic polymorphism with a predetermined genetic polymorphism so as to assess the risk of suffering from the gout of the subject. | 2010-09-30 |
20100248254 | ASSESSMENT AND REDUCTION OF RISK OF GRAFT-VERSUS-HOST DISEASE - Methods of assessing and reducing risk of graft versus host disease (GVHD) based on gene expression profiling are described, as well as methods of selecting a suitable transplant donor. Corresponding reagents and kits are also described. | 2010-09-30 |
20100248255 | NOVEL PEPTIDES - The present invention provides novel peptides with circulation-modulating activity. These peptides are useful as circulation-modulating agents and vasopressors because of their circulation-modulating activity, and can be used for treating diseases of the circulatory system such as myocardial infarction, ischemic heart disease, cerebral infarction, or the like. | 2010-09-30 |
20100248256 | HEPATOCELLULAR CARCINOMA PROTEIN MARKER, AND METHOD FOR DETECTION OF HEPATOCELLULAR CARCINOMA USING THE SAME - Provided are: a method of assessing hepatocellular carcinoma by using a protein with a different phosphorylated state in hepatocellular carcinoma cells compared with non-hepatocellular carcinoma cells; and a hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma formed of the protein. The hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma includes tumor rejection antigen gp96 formed of the amino acid represented by SEQ ID NO: 1, and is measured for its phosphorylated state to detect the presence or absence of hepatocellular carcinoma. | 2010-09-30 |
20100248257 | Compiled Methods for Analysing and Sorting Samples - The present invention relates to the fields of analysis, diagnostics, prognostics, standardization, characterization and enumeration of entities such as biological cells, as well as therapeutical applications. Accordingly, the present invention in preferred aspects is directed to methods for the detection and/or analysis and/or isolation and optionally further manipulation of entities, such as cells, particles, and supra-molecular structures. | 2010-09-30 |
20100248258 | Immunoassay biochip - The present invention is about a microfluidic chip for rapid detection of different target proteins and a method for using the same. The microfluidic chip utilizes antibody-conjugated magnetic beads to bind to the target proteins to form a magnetic complex, and then use the signal labeled-antibodies that can recognize said magnetic complex. Purifying said magnetic complex by the micro-magnetic field on biochip, and introducing said purified magnetic complex into the fluorescent detection area on the chip to detect the amount of the target protein in said purified complex immediately. | 2010-09-30 |
20100248259 | NATRIURETIC PEPTIDE/GDF-15 RATIO FOR DIAGNOSIS OF CARDIAC DISORDERS - The present invention is concerned with methods and devices for medical diagnosis. Specifically, it relates to a method of diagnosing a cardiac disorder, the method including (a) determining the amount of a natriuretic peptide in a sample of the subject, (b) determining the amount of GDF-15 in a sample of the subject, (c) calculating the ratio (natriuretic peptide/GDF-15), and (d) diagnosing if the subject is suffering from a cardiac disorder, based of the ratio calculated in step (c). The method allows determining whether an elevated amount of GDF-15 in a sample of a subject is related to cardiac disorders, in particular myocardial dysfunction and/or heart failure, or if the elevation is related to a different pathological state Moreover, the present invention relates to a diagnostic device and a kit for carrying out the aforementioned method. | 2010-09-30 |
20100248260 | GLYCOSAMINOGLYCAN-COATED PARTICLES AND USES THEREOF - The present invention is directed to metallic particles coated with glycosaminoglycans and methods for preparing them. Methods of using such glycosaminoglycan-coated metallic particles in biomedical and other applications are also disclosed. In certain embodiments, methods for assaying glycosaminoglycan-degrading activity in biological fluids, test samples, and/or therapeutic formulations using the glycosaminoglycan-coated particles are provided. Such methods may be used, for example, in diagnostic tests for diseases such as cancer, inflammatory diseases, or autoimmune diseases and to test activity of enzymes being developed as therapeutics. | 2010-09-30 |
20100248261 | METHOD TO DETERMINE PROTEIN INTERACTION SITES - The invention provides improved crosslinkers which permit more efficient determination of protein interactions in biological samples. | 2010-09-30 |
20100248262 | Anti-Fibronectin Fragment Monoclonal Antibody - A method for measuring a fibronectin fragment which is easy to handle and has excellent measuring accuracy, specificity and reproducibility is provided. An anti-fibronectin fragment monoclonal antibody which reacts with a human fibronectin fragment but does not react with human fibronectin, a measuring reagent containing the monoclonal antibody, a method for measuring a fibronectin fragment which uses the monoclonal antibody and a hybridoma which produces the monoclonal antibody are provided. | 2010-09-30 |
20100248263 | BIOMARKERS ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION - The invention relates to proteins associated with age-related macular degeneration (AMD). These proteins, which are present in blood, are expressed in individuals with AMD at either elevated or reduced levels compared to healthy individuals. The invention provides methods for diagnosing AMD. The invention provides methods for assessing the efficacy of treatment of AMD. The invention provides methods for monitoring the progression of AMD. | 2010-09-30 |
20100248264 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions - Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided. | 2010-09-30 |
20100248265 | COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF CANCER - Provided herein are methods and compositions useful in the diagnosis and treatment of cancer. The methods and compositions typically involve detecting a level of phosphorylation of mTOR at serine 2481 in a subject and comparing the level of phosphorylation of mTOR at serine 2481 in said subject with a standard control. | 2010-09-30 |
20100248266 | PURINERGIC (P2X) RECEPTORS IN EXTRA-CELLULAR BODY FLUID - The invention relates to purinergic (P2X) receptors, to detection of protein in extra-cellular body fluids and to antibodies for the diagnosis of a disease or condition, especially cancer. | 2010-09-30 |
20100248267 | METHOD FOR MEASUREMENT OF CONCENTRATION OF ANTIGEN - The object of the present invention is to provide a detection method that can detect an antigen even if the target antigen has a low molecular weight in a simpler, more efficient, and more stable manner and with higher sensitivity. The detection of the antigen is carried out by using a fusion protein comprising a polypeptide containing a V | 2010-09-30 |
20100248268 | Methods to utilize invertebrate chemosensory proteins for industrial and commercial uses - This invention provides methods and compositions for using chemosensory proteins derived from invertebrates to bind or detect specific compounds. Applications include use as detector elements in biosensors or other sensory devices and purification or concentration devices. Examples of proteins involved in the chemosensory pathway include odorant binding proteins (OBPs), sensory appendage proteins (SAPs), orthologs of the | 2010-09-30 |
20100248269 | DETECTION OF FIBRIN AND FIBRINOGEN DEGRADATION PRODUCTS AND ASSOCIATED METHODS OF PRODUCTION AND USE FOR THE DETECTION AND MONITORING OF CANCER - Disclosed herein are methods, systems and kits for the detection of, or monitoring the progression of, cancer by simultaneously detecting the presence of six fibrin and fibrinogen degradation products (FDP) in a biological sample in a single assay system. | 2010-09-30 |
20100248270 | Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Cardiac Disease - Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states. | 2010-09-30 |
20100248271 | Fibrinogen Alpha and Hemoglobin Polypeptides as Cancer Markers - The present invention provides methods of detecting cancer using biomarkers. | 2010-09-30 |
20100248272 | Method for identifying Smk box riboswitch modulating compounds - The invention is directed, inter alia, to a method for identifying a compound that modulates a gene expression of an mRNA molecule containing a S | 2010-09-30 |
20100248273 | AMELIORATION OF HETEROPHILE ANTIBODY IMMUNOSENSOR INTERFERENCE - The invention is directed to methods and devices for reducing interference from heterophile antibodies in an analyte immunoassay. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with non-human IgM or fragments thereof by dissolving into said sample a dry reagent to yield a non-human IgM concentration of at least about 20 μg/mL or equivalent fragment concentration; and (b) performing an electrochemical immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG or fragments thereof in addition to the IgM of fragments thereof. | 2010-09-30 |
20100248274 | ANTIBODY DIRECTED AGAINST PRO-GASTRIN RELEASING PEPTIDE, AND USE THEREOF - Disclosed is a novel high-sensitive ProGRP measurement method, which is free from problems such as the fluctuations in measurement values and the operational constraints (e.g., the constraints on the handling of a sample). Specifically disclosed is a method for the measurement of a gastrin-releasing peptide precursor and/or a digested product thereof using at least two different antibodies each of which can recognize an epitope represented by the amino acid sequence consisting of amino acid 47 to amino acid 68 of the amino acid sequence set forth in SEQ ID NO:1. The method can detect a ProGRP or a digested product thereof in a refrigerated sample within a shorter period, by using the sample in a smaller amount, and with a higher degree of detective sensitivity, compared with the conventional methods. | 2010-09-30 |
20100248275 | METHODS FOR PREDICTING OUTCOME IN TRAUMATIC BRAIN INJURY - The invention describes methods for predicting outcome for patients suffering from traumatic brain injury (TBI) by evaluating levels of markers commonly associated with cellular damage in bodily fluids. Utilization of such methods improves diagnosis and treatment of patients suffering from traumatic brain injury, thus potentially minimizing and/or eliminating long-term adverse effects in these patients. | 2010-09-30 |
20100248276 | METHOD FOR MEASURING LOW DENSITY LIPOPROTEIN CHOLESTEROL - It is an object of the present invention to provide a method for measuring low density lipoprotein cholesterol (LDL-C) in a body fluid, which is able to selectively measure low density lipoprotein cholesterol in a body fluid without using a low density lipoprotein cholesterol-selective surfactant having a risk of generating endocrine-disrupting chemicals. The present invention provides a method for measuring low density lipoprotein cholesterol (LDL-C) in a body fluid, which comprises measuring low density lipoprotein cholesterol (LDL-C) by using (a) cholesterol esterase and (b) cholesterol oxidase or cholesterol dehydrogenase, in the presence of a polyoxyethylene-polyoxypropylene copolymer and a polyglyceryl ether. | 2010-09-30 |
20100248277 | DETECTION AND QUANTIFICATION OF ANALYTES IN BODILY FLUIDS - This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. | 2010-09-30 |
20100248278 | METHOD AND A DEVICE FOR CHARACTERIZING THE COAGULATION OR SEDIMENTATION DYNAMICS OF A FLUID SUCH AS BLOOD OR BLOOD PLASMA - A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma, the method comprising: illuminating a sample of said fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction between said sample and said spatially coherent light beam; and processing said time series of images; wherein said processing step includes calculating a function representative of the variation in said speckle pattern between two or more images of the series. The invention also provides a device for implementing such a method. | 2010-09-30 |
20100248279 | SUBSTRATE PROBE, ENZYME-ACTIVITY DETECTION METHOD BY A MULTI-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE METHOD AND ENZYME-ACTIVITY IMAGING METHOD - Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method. | 2010-09-30 |
20100248280 | Method for Identifying a Compound that Modulates Telomerase Activity - The present invention relates to a method for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain of telomerase and testing the compound for its ability to modulate the activity of telomerase. | 2010-09-30 |
20100248281 | RAPID DETECTION OF REPLICATING CELLS - The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance. | 2010-09-30 |
20100248282 | DETECTION OF NO BY USING GUANYLYL CYCLASE AND cGMP PRODUCTION AS A READOUT SYSTEM - The present invention relates to a method for determining NO enzymatically and its use for the identification of substances which can modulate a nitric oxide synthase activity. | 2010-09-30 |
20100248283 | Portable surface plasmon resonance biosensor - A surface plasmon resonance biosensor device and system are provided. The simplicity of SPR biosensor design allows easy integration with both QCM and electrochemistry techniques, not found in current SPR biosensor devices. In some embodiments, the surface plasmon resonance biosensor device has a dual SPR/QCM sample holder which allows simultaneous detection by both surface plasmon resonance and also quartz crystal microbalance (QCM) techniques. In additional embodiments, the surface plasmon resonance biosensor device and/or the dual SPR/QCM technique can be integrated with electrochemistry techniques by incorporate reference and counter electrodes in the SPR or SPR/QCM sample holder. Methods of using the device and system to determine whether an analyte of interest is present in a sample are also provided. | 2010-09-30 |
20100248284 | BIOSENSOR - A biosensor which comprises a substrate ( | 2010-09-30 |
20100248285 | Method And Apparatus For The Processing And/Or Analysis And/Or Selection Of Particles, In Particular Biological Particles - Methods and apparatus are described for the processing (for example washing, incubation, etc.) of particles in which the particles suspended in a first fluid are introduced under laminar flow conditions into at least one first microchamber or first region of the same, in which a second fluid is introduced under laminar flow conditions into at least one second region of the microchamber or of a second microchamber, in such a way as not to mix with the first fluid, and in which at least one field of force acting on the particles is activated in the microchamber(s), to provoke a shift of the particles alone in a predetermined direction and to transfer the same in suspension into the second fluid; an apparatus is preferably used including at least three microchambers n microchambers arranged in sequence with each other in one direction and each connected with the microchamber immediately before it and after it with two orifices offset from each other in a direction perpendicular to the direction of sequence of the microchambers. | 2010-09-30 |
20100248286 | BIOSENSORS BASED ON MICROALGAE FOR THE DETECTION OF ENVIRONMENTAL POLLUTANTS - The present invention provides biosensors based on microalgae for the determination of the presence of toxic compounds in a sample, characterized by the high sensitivity and specificity thereof with respect to the target toxic substance. The biosensors are based on the measurement of the photosynthetic activity of algae by means of monitoring the molecular oxygen production by the microalgae by using a luminescent compound the emission of which depends on the amount of oxygen in the medium. | 2010-09-30 |
20100248287 | DECONTAMINATION OF PRION-CONTAMINATED SURFACES WITH PHENOLS - A method of decontaminating a surface or liquid which is contaminated with prions includes treating the surface with a composition which includes one or more phenol. Phenols which are particularly effective include p-chloro-m-xylanol, thymol, triclosan, 4-chloro, 3-methylphenol, pentachlorophenol, hexachlorophene, 2,2-methyl-bis(4-chlorophenol), and p-phenylphenol. | 2010-09-30 |
20100248288 | DIFFERENTIATION OF CAUSES OF RIGHT HEART FAILURE - The present invention relates to the field of diagnostic means and methods. More specifically, the present invention relates to a method of differentiating between pulmonary embolism and pulmonary hypertension as the cause of right heart failure in a subject comprising determining the amounts of a natriuretic peptide, a cardiac troponin, GDF-15 and endoglin in a sample of a subject suffering from right heart failure and comparing the amounts with reference amounts, whereby it is differentiated between pulmonary embolism and pulmonary hypertension as the cause of the right heart failure. Furthermore, the present invention relates to methods of determining whether a subject suffering from right heart failure is susceptible to a therapy for pulmonary hypertension or pulmonary embolism as well as to a diagnostic device and a diagnostic kit adapted for carrying out the method of the present invention. | 2010-09-30 |
20100248289 | REAGENT PREPARING DEVICE, REAGENT PREPARING METHOD AND SPECIMEN PROCESSING SYSTEM - A reagent preparing device for preparing a reagent to be supplied to a measurement section for measuring a specimen; the reagent preparing device comprising: a reagent preparing section for preparing a reagent including a first liquid and a second liquid, different from the first liquid; a reagent storage container, connected to the measurement section, for storing the reagent prepared by the reagent preparing section; and a controller configured for determining whether or not the reagent stored in the reagent storage container is suppliable to the measurement section based on reagent expiration date information related to an expiration date of the reagent stored in the reagent storage container, is disclosed. A reagent preparing method and a specimen processing system are also disclosed. | 2010-09-30 |
20100248290 | METHODS FOR DETECTING LUNG CANCER AND MONITORING TREATMENT RESPONSE - A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment with curative intent is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with the a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described. | 2010-09-30 |
20100248291 | METHODS FOR IDENTIFYING, PURIFYING AND ENRICHING IMMATURE OR STEM CANCER-INITIATING CELLS FROM TUMORS AND USE THEREOF - The present invention is related to methods for the preparation of cell compositions, isolated compositions obtainable therefrom, related isolated cell compositions, kits and use thereof. More specifically, the present invention provides a method for identifying, purifying and enriching immature or stem cancer-initiating cells in a 5 sample. The cell compositions, related methods and uses according to the present invention are useful in the treatment of cancers and/or the detection of enriching immature or stem cancer-initiating cells, notably cancers of the central and peripheral nervous system, metastasis to the brain. | 2010-09-30 |
20100248292 | SAMPLE PROCESSING APPARATUS AND SAMPLE PROCESSING METHOD - A sample processing apparatus comprising: an aspiration section for aspirating a sample from a sample container; a sample container take-out/returning section for taking out a sample container containing a sample from a sample rack holding a plurality of sample containers, and for returning the sample container, from which the sample has been aspirated, to the sample rack; a sample processing section for processing the aspirated sample; a transport section for transporting the sample rack to a take-out position for taking out the sample container from the sample rack; and a transport controller for controlling the transport section to transport the sample rack to a processing position for performing a predetermined process on another sample container held by the sample rack when one sample container has been taken out from the sample rack by the sample container take-out/returning section is disclosed. A sample processing method is also disclosed. | 2010-09-30 |
20100248293 | SAMPLE ANALYZER AND SAMPLE ANALYZING METHOD - The present invention is to present a sample analyzer comprising: a first measurement unit; a second measurement unit; a transport unit for transporting a sample container to the first measurement unit and the second measurement unit; and a controller configured to perform operations comprising: obtaining measurement item information indicating a measurement item of the sample contained in the sample container; and controlling the transport unit so as to transport the sample container to the second measurement unit when a first measurement item and a second measurement item different from the first measurement item are indicated in the measurement item information, and controlling the transport unit so as to transport the sample container to the first measurement unit or the second measurement unit when the first measurement item is indicated and the second measurement item is not indicated in the measurement item information. | 2010-09-30 |
20100248294 | ANALYTIC SUBSTRATE COATING METHOD - An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production. | 2010-09-30 |
20100248295 | ANALYTIC SUBSTRATE COATING METHOD - An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production. | 2010-09-30 |
20100248296 | STERILIZATION INDICATOR - The disclosed technology relates to a sterilization indicator and a process to concentrate signal generated by constraining it to a minimal surface, in a minimal volume and minimal pH and growth buffering or mediating influences. The sterilization indicator may comprise a carrier | 2010-09-30 |
20100248297 | PARTICLES AND MANUFACTURING METHODS THEREOF - Particles and manufacturing methods thereof are provided. The manufacturing method of the particle includes providing a precursor solution containing a precursor dissolved in a solution, and irradiating the precursor solution with a high energy and high flux radiation beam to convert the precursor to nano-particles. Particles with desired dispersion, shape, and size are manufactured without adding a stabilizer or surfactant to the precursor solution. | 2010-09-30 |
20100248298 | MASS SPECTROMETRIC IDENTIFICATION OF MICROORGANISMS IN COMPLEX SAMPLES - Microorganisms are identified as present in a complex sample or mixed culture by acquiring a mass spectrum of the sample and comparing it to combination spectra, each of which is formed by combining at least two reference mass spectra of known microorganisms. Microorganisms corresponding to the reference spectra used to form the combination spectrum are identified as present in the sample if that combination spectrum exhibits a better match with the sample mass spectrum than any one of reference mass spectra used to form that combination spectrum. It is also possible to identify microorganisms by forming a difference spectrum by subtracting a reference mass spectrum from the sample mass spectrum and comparing the difference spectrum to the reference mass spectra. | 2010-09-30 |
20100248299 | Microbial Detection and Quantification - Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye. | 2010-09-30 |
20100248300 | BLOOD ANALYZER, BLOOD ANALYZING METHOD, AND COMPUTER PROGRAM PRODUCT - A blood analyzer comprising: a specimen preparation section for preparing a measurement specimen that is used to measure a white blood cell count among CBC measurement items; a measurement section for obtaining optical information from blood cells contained in the measurement specimen; and a controller carrying out operations comprising: classifying blood cells contained in the measurement specimen into at least white blood cells and blood cells suspected to be abnormal blood cells based on the optical information; obtaining distribution data of the white blood cells and distribution data of the blood cells suspected to be abnormal blood cells; counting the white blood cells based on the distribution data of the white blood cells; and determining presence or absence of the abnormal blood cells in the blood sample, based on the distribution data of the blood cells suspected to be abnormal blood cells. A blood analyzing method and a computer program product are also disclosed. | 2010-09-30 |
20100248301 | Tissue Embedding Apparatus, And Method For Operating A Tissue Embedding Apparatus - The present invention relates to a tissue embedding apparatus ( | 2010-09-30 |
20100248303 | METHOD FOR RECOVERING PEPTIDES/AMINO ACIDS AND OIL/FAT FROM ONE OR MORE PROTEIN-CONTAINING RAW MATERIALS, PRODUCTS PRODUCED BY THE METHOD, AND USE OF THE PRODUCTS - According to a first aspect, hydrolysation of a protein-containing raw material and separation of amino acids/peptides is carried out, wherein the hydrolysation is effected by using the endogenous enzymes of the protein-containing raw material. The hydrolysate is passed through a membrane filter, wherein peptide/amino acids follow a permeate stream, whilst the active enzymes continuously break down any protein residues that are deposited on the membrane surface. The enzymes are passed together with retenate back to the hydrolysis. Furthermore, an amino acid and peptide product and an oil product are described and the use thereof is disclosed. | 2010-09-30 |
20100248304 | DUAL EXPRESSION VECTOR SYSTEM AND SCREENING METHODS - The present invention features vectors that contain a promoter effective for expression in bacterial cells and a promoter effective for expression in insect cells. The dual promoter system allows use of the same vector in both host cell systems so that construction of only a single vector is needed to express a polynucleotide inserted at a downstream cloning site. In preferred embodiments the vector is used to derive a recombinant baculovirus that is used to infect host cells. In particular vectors the promoters are a baculovirus polh promoter and a T7lac promoter. In particular vectors the promoter effective for expression in bacteria is positioned between the promoter effective for expression in insect cells and a cloning site. The invention also features various high throughput screening methods. | 2010-09-30 |
20100248305 | POLYAMINO ACID SYNTHETASE AND GENE ENCODING THE SAME - The present invention provides an enzyme which catalyzes amino acid polymerization in the form of a non-ribosomal peptide synthetase (NRPS) and a gene encoding the same. | 2010-09-30 |
20100248306 | Expression System for the Antibiotic-Free Production of Polypeptides - The invention relates to an expression system for the production of one or more target polypeptide/target polypeptides, comprising a host cell in whose genome the DNA sequence that codes glycerine-3-phosphate dehydrogenase is inactivated or partially or completely deleted and which is transformed by an extrachromosomal element that comprises a DNA sequence that codes the target polypeptide(s) and glycerine-3-phosphate dehydrogenase, whereby not only the host cell genome but also the extrachromosomal element do not carry an antibiotic-resistance gene, as well as a DNA sequence that codes for a polypeptide with glycerine-3-phosphate dehydrogenase activity characterized in that the DNA sequence is selected from a) DNA sequences that comprise a nucleotide sequence according to SEQ ID NO: 1, b) DNA sequences that comprise a nucleotide sequence represented by the nucleotides 1338 to 2375 of SEQ ID NO: 1, c) DNA sequences that are coded by the plasmid pTP01 with the plasmid map according to FIG. | 2010-09-30 |
20100248307 | PEPTIDE PRODUCTION METHOD - According to the present invention, a protein having peptide-synthesizing activity, a DNA encoding the protein, a recombinant DNA containing the DNA, a transformant obtained via transformation with the recombinant DNA, a process for producing a protein having peptide-synthesizing activity using the transformant and the like, a process for producing a peptide using a protein having peptide-synthesizing activity, and a process for producing a peptide using as an enzyme source a culture or the like of a transformant or a microorganism producing a protein having peptide-synthesizing activity are provided. | 2010-09-30 |
20100248308 | Recombinant Microorganism and a Method for Producing Poly-Gamma-Glutamic Acid - A recombinant microorganism having poly-γ-glutamic acid-producing ability, prepared by introducing a | 2010-09-30 |
20100248309 | THERMOSTABLE ALPHA1-ANTITRYPSIN MUTEIN WITH A DISULFIDE BOND AND THE METHOD FOR PREPARING IT - The present invention relates to a thermostable alpha-1-antitrypsin mutein with a disulfide bond and a preparation method of the same, more precisely an alpha-1-antitrypsin mutein with improved thermostability, compared with the conventional thermostable alpha-1-antitrypsin mutein (Korean Patent No. 133252), resulted from the process of substituting the 168 | 2010-09-30 |
20100248310 | METHOD OF DNA AMPLIFICATION - The present invention relates generally to a method of amplifying a nucleic acid region of interest and, more particularly, to a method of amplifying a nucleic acid region of interest using a PCR method designed to minimise the generation of amplicons from primers which have bound to nucleic acid regions other than the specific region of interest. The method of the present invention is based on the determination that by rendering inefficient the functionality of either the forward primer or the reverse primer, the rate of amplification of irrelevant nucleic acid regions can be reduced relative to amplification of the region of interest. The provision of a selective means of amplifying a nucleic acid region of interest is useful in a range of applications including, but not limited to, the diagnosis and/or monitoring of disease conditions which are characterised by specific gene sequences, the characterisation or analysis of gene regions of interest, the identification or characterisation of DNA breakpoint regions and the isolation of gene sequences of interest where only the nucleotide sequence at one end of the gene sequence of interest is known. | 2010-09-30 |
20100248311 | INCREASING METHIONINE YIELD - Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described. | 2010-09-30 |
20100248312 | Alanine 2,3-aminomutases and related polynucleotides - The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides. | 2010-09-30 |
20100248313 | NOVEL OPTICALLY ACTIVE, HETEROAROMATIC BETA-HYDROXY ESTERS AND PROCESSES FOR THEIR PREPARATION FROM BETA-KETO ESTERS AND PROCESSES FOR THE PREPARATION OF THESE BETA-KETO ESTERS - The present invention relates to new optically active heteroaromatic β-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production. | 2010-09-30 |
20100248314 | PROCESS FOR PRODUCTION OF SUCCINIC ACID AMIDE COMPOUND - Disclosed is a novel process for producing a compound represented by the general formula (1) by using a microorganism, wherein the compound is useful as a plant growth stimulant. Specifically disclosed is a process for producing a succinic acid amide compound represented by the general formula (1) [wherein Ar represents a phenyl, naphthyl or indolyl group which may have a substituent; and n represents a numeral value ranging from 1 to 4] or a salt thereof, which is characterized by culturing a microorganism of the genus | 2010-09-30 |
20100248315 | Fermentative vitamin C production - The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 2010-09-30 |
20100248316 | Process for the Production of Ambrafuran - A method for the cyclodehydration of a 1,4- or 1,5-diol includes the step of exposing a 1,4- or a 1,5-diol to an activated zeolite at a temperature of between about 0° C. and about 110° C. for a period of between about 1 and 24 hours. The activated zeolite is prepared from an inactive NaY or CaY type zeolite by ion exchange with an ammonium salt, to produce an ammonium zeolite and exchange of at least part of the ammonia of the ammonium zeolate with a group II A metal. | 2010-09-30 |
20100248317 | PROCESS FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF INTERMEDIATES - A process for the enantioselective enzymatic reduction of a keto compound of general formula I | 2010-09-30 |
20100248318 | HYDROGEN PROCESSING AND IMPURITY REMOVAL AND CLEANING METHODS IN A BIOMASS CONVERSION PROCESS - In one embodiment, the disclosure includes a method of biomass conversion including fermenting biomass to produce a carboxylic acid or carboxylate salt and hydrogen gas, recovering the hydrogen gas, and converting the carboxylic acid or carboxylate salt to an alcohol using the hydrogen gas. In one embodiment, the hydrogen produced by biomass conversion may be converted to an acetate. Another embodiment relates to a biomass conversion system. The system may include: a fermentation unit for fermentation of biomass to a carboxylic acid or carboxylate salt in a fermentation broth and for production of a carbon dioxide and hydrogen gas stream, an extraction unit for extracting the carboxylic acid or carboxylate salt from the fermentation broth, a gas extraction unit for separation of the hydrogen gas and the carbon dioxide, and a production unit for production of an alcohol from the carboxylic acid or carboxylate salt using the hydrogen gas. | 2010-09-30 |
20100248319 | Ethanol Production - This invention relates to ethanol production as a product of bacterial fermentation. | 2010-09-30 |
20100248320 | COMPOSITIONS AND METHODS FOR CONVERSION OF LIGNOCELLULOSIC MATERIAL TO FERMENTABLE SUGARS AND PRODUCTS PRODUCED THEREFROM - The present invention relates to compositions and methods for the conversion of lignocellulosic material to fermentable sugars and to products produced therefrom (e.g., ethanol, foodstuffs, etc.). In particular, the invention provides lignocellulose-degrading compositions (e.g., generated via incubation of microbes with lignocellulosic priming feedstock in solid-state fermentation format) and methods of using the same (e.g., in saccharification and/or hydrolysis steps (e.g., on ethanologenic feedstock) and as food or feed additives). | 2010-09-30 |
20100248321 | SURFACTANT AMENDMENTS FOR THE STIMULATION OF BIOGENIC GAS GENERATION IN DEPOSITS OF CARBONACEOUS MATERIALS - Methods of conditioning a carbonaceous material in a subterranean geologic formation for metabolism into a compound with enhanced hydrogen content by a microorganism consortium are described. The methods may include the steps of accessing the subterranean geologic formation through an access point, and contacting the carbonaceous material with a surfactant. The microorganism consortium can utilize the surfactant as a first nutrient source. The surfactant also increases accessibility of the carbonaceous material as a second nutrient source for the microorganism consortium. The microorganism consortium metabolizes the carbonaceous material into the compound with the enhanced hydrogen content. | 2010-09-30 |
20100248322 | CHEMICAL AMENDMENTS FOR THE STIMULATION OF BIOGENIC GAS GENERATION IN DEPOSITS OF CARBONACEOUS MATERIAL - Methods of stimulating biogenic production of a metabolic product with enhanced hydrogen content are described. The methods may include accessing a geologic formation that includes carbonaceous material. The methods may also include introducing an amendment to the geologic formation. The amendments may further include removing compounds with enhanced hydrogen content from the formation. | 2010-09-30 |
20100248323 | Carbonic anhydrase bioreactor and process for CO2 containing gas effluent treatment - A triphasic bioreactor for physico-chemically treating a gas is disclosed. The triphasic bioreactor comprises a reaction chamber with a liquid and biocatalysts in suspension in the liquid, for catalyzing a reaction between the gas and the liquid to obtain a treated gas and a solution containing a reaction product. A gas bubbling means is provided in the reaction chamber for bubbling the gas to be treated into the liquid thereby dissolving the gas into the liquid and increasing a pressure inside the reaction chamber. The bioreactor further comprises a liquid inlet in fluid communication with the reaction chamber for receiving the liquid and filling the reaction chamber, a liquid outlet in fluid communication with the reaction chamber for releasing the solution and a gas outlet in fluid communication with the reaction chamber to release the treated gas. The bioreactor further comprises a retention device to retain the biocatalysts in the reaction chamber. The invention also concerns a process using the triphasic bioreactor. The triphasic bioreactor may advantageously be used for removing carbonic dioxide from a CO | 2010-09-30 |
20100248324 | Expandable Functional TFE Copolymer Fine Powder, the Expandable Functional Products Obtained Therefrom and Reaction of the Expanded Products - A functional TFE copolymer fine powder is described, wherein the TFE copolymer is a polymer of TFE and at least one functional comonomer, and wherein the TFE copolymer has functional groups that are pendant to the polymer chain. The functional TFE copolymer fine powder resin is paste extrudable and expandable. Methods for making the functional TFE copolymer are also described. The expanded functional TFE copolymer material may be post-reacted after expansion. | 2010-09-30 |
20100248325 | SELF-CROSSLINKING POLYSILOXANES IN COATINGS OF ENZYME IMMOBILIZATES - Enzyme preparations obtainable by providing an enzyme immobilizate with a silicone coating, the coating being obtained by hydrosilylating a self-crosslinking polysiloxane, a process for production thereof and the use thereof are provided. | 2010-09-30 |
20100248326 | STABILIZATION OF THERMOLYSIN IN AQUEOUS SOLUTION - The present invention deals with the proteolytic enzyme thermolysin which tends to be unstable in aqueous solution. The invention provides methods and compositions to enhance the stability of dissolved thermolysin in aqueous solution. Thermolysin, crude thermolysin or a lyophilisate containing thermolysin and one or more salts, is contacted with an aqueous buffer with a low salt concentration and a first solution is formed. Subsequently, a further salt in solid form is added and dissociated, thereby forming a second solution comprising thermolysin in a stabilized form. | 2010-09-30 |
20100248327 | CYTOCHROME P450 OXYGENASES - Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3. | 2010-09-30 |
20100248328 | HYPERACTIVE VARIANTS OF 5-AMINOLEVULINATE SYNTHASE AND METHODS OF USE - The rate of porphyrin biosynthesis in mammals is controlled by the activity of the pyridoxal 5′-phosphate-dependent enzyme 5-aminolevulinate synthase. Assuming the turnover in this enzyme is controlled by conformational dynamics at a highly conserved active site loop, a variant library was constructed by targeting imperfectly conserved non-catalytic loop residues and the effects on product and porphyrin production were examined. Functional loop variants of the enzyme were tested for porphyrin fluorescence, which varied widely and thus facilitated identification of clones encoding unusually active enzyme variants. Nine loop variants leading to high in vivo porphyrin production were purified and characterized kinetically. Steady-state catalytic efficiencies for the two substrates were increased by up to one hundred-fold. The data support the postulate that the active site loop controls the rate of product and porphyrin production in vivo and suggest the possibility of an as yet undiscovered means of allosteric regulation. | 2010-09-30 |
20100248329 | BLOOD COAGULATION PROMOTER AND BLOOD COLLECTION TUBE - The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability, and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom. | 2010-09-30 |
20100248330 | Flow-Controlling Header - An apparatus and method for holding a membrane, screen or other flexible planar body in tension, while providing a conduit for water or other liquid to flow to the membrane being held. The membrane extends from inside a manifold body that carries the liquid, and the manifold body supports the membrane at one edge while the membrane is pulled in tension. Liquid pressure builds up inside the manifold body, preferably by entering a pressure chamber at the top of the manifold body. At a feeding pressure in the pressure chamber the liquid is distributed to the membrane for microbe growth. The liquid can be elevated to a higher, microbe-harvesting pressure by increasing the pressure in the pressure chamber, thereby deflecting a shim separating the pressure chamber from the membrane. The change in pressure is carried out by manually or automatically opening and closing a conventional water valve. | 2010-09-30 |
20100248331 | SELECTIVE GROWTH MEDIA - Disclosed is a method of selectively inhibiting for growth of non-target cells in a mixed population of target and non-target cells, the method comprising the steps of: (a) contacting the mixed population with a selective agent which comprises a carrier moiety linked by a scissile linkage to a toxic moiety; wherein the selective agent is able to enter non-target cells in which the scissile linkage is cleaved, releasing the toxic moiety to exert a toxic effect on the non-target cells causing inhibition of the growth of the non-target cells, whereas the selective agent is unable to enter target cells and/or the scissile linkage is not cleaved in target cells and/or toxic moiety, if released from the selective agent, does not exert a toxic effect on the target cell; and (b) culturing the cells in conditions which allow for growth of non-inhibited cells. | 2010-09-30 |
20100248332 | Yeast used for pizza and its production method - A yeast used for pizza and its production method are provided. The yeast is dry yeast, and the amount of CO | 2010-09-30 |
20100248333 | Photobioreactor System and Method For the Growth of Algae for Biofuels and Related Products - A photobioreactor includes an upper layer of transparent film and a lower layer of film wherein the upper layer and lower layer are attached to each other along the perimeter to form a sealed structure, the upper layer and lower layer also attached to form pathways comprising independent channels within the confines of the outer perimeter, a first manifold and second manifold on opposite ends of the parallel channels within the sealed structure wherein a first portion of the first manifold is in fluid communication with each of an inlet of a first subset of the channels and a second portion of the first manifold is in fluid communication with each of an outlet of a second subset of the channels and wherein the second manifold is in fluid communications with the distal end of the parallel channels plumbing apparatus comprising a degas vessel in fluid communication with the first manifold; and wherein the structure is substantially horizontal in operation. | 2010-09-30 |
20100248334 | Biological active coating components, coatings, and coated surfaces - Disclosed herein are novel coatings and paints comprising a biomolecule composition, wherein the biomolecule composition comprises a phosphoric triester hydrolase. Also disclosed herein are methods of detoxification of a surface contaminated with an organophosphorus compound by contacting the surface with such a coating or paint. Also disclosed herein are novel coating and paint components derived from microorganisms. | 2010-09-30 |
20100248335 | METHOD AND APPARATUS FOR TREATMENT OF ORGANIC WASTE - The pH condition in a methane fermentation tank is adjusted in a predetermined range equal to or less than the intended pH condition causing no scale formation, while being maintained in a predetermined range approximate to an optimized pH condition suitable for methane fermentation, and thereby the formation of inorganic scales and the like is suppressed. | 2010-09-30 |
20100248336 | METHODS FOR PURIFYING NUCLEIC ACIDS - Methods are provided for producing highly purified compositions of nucleic acids by using a highly streamlined and readily automated process. The methods use static mixers for lysing cells and precipitating debris, following by centrifugation and ion exchange chromatography. The process may include a purification step using tangential flow ultrafiltration. A scaleable process for producing pharmaceutical grade plasmid DNA, useful for gene therapy, is provided. | 2010-09-30 |
20100248337 | PROCESS FOR THE PRODUCTION OF (s)-5-CHLORO-2-ISOPROPYLPENT-4-ENOIC ACID ESTERS - A process for preparing a compound of formula (1) in enantiomerically enriched form, which comprises selective hydrolysis of the corresponding racemic compound (2) catalysed by an enzyme derived from a non-mammalian source and having esterase or lipase activity, wherein R is methyl or C | 2010-09-30 |
20100248338 | CELL TREATMENT DEVICE, CELL TREATMENT CARTRIDGE AND BODY FLUID TREATMENT SYSTEM - A cell treatment device which allows cell dispersion liquid including cancer cells to pass therethrough to cause at least the cancer cells to be subjected to at least one of a physical action, a chemical action, and a biologically activating action, includes: a slit member having a first surface and a second surface and including a through hole having a slit shape penetrating from the first surface to the second surface and extending in one direction, the through hole having a tapered portion, wherein the width of a cross section of the tapered portion orthogonal in the one direction reduces from the first surface toward the second surface side, and is smaller than an average diameter of the cancer cells at an end on the second surfaces side, and the cell dispersion liquid is allowed to pass from the first surface side through the through hole to the second surface side. | 2010-09-30 |
20100248339 | TIP DRIVE APPARATUS - A tip, drive apparatus is capable to moving a tip unit toward an object, while holding the tip unit at a prescribed angle. The tip unit is formed on a support unit having flexibility and directed to the object at the prescribed angle. The tip drive apparatus includes a needle having a shaft to which the support unit on which the tip unit is formed, and an adaptor configured to hold the needle, enabling the needle to be replaced by another. The adaptor is configured to be able to change a positional relation with respect to the main unit of the tip drive apparatus, while the needle is being attached. | 2010-09-30 |
20100248340 | NEEDLE - A needle designed to be manipulated on a single cell includes a cantilever tip including a support unit and a tip unit formed at a prescribed angle to the support unit, and a shaft connected to the cantilever tip. The needle is attachable, via at least the shaft, to a tip drive apparatus capable of moving the tip unit in a prescribed direction. | 2010-09-30 |
20100248341 | TIP DRIVE APPARATUS - A tip drive apparatus includes a shaft to which a support unit on which a tip unit is formed, and a main unit configured to move the shaft, thereby to move the tip unit toward an object while remaining held at a prescribed angle. The shaft is arranged to meet four requirements including a first requirement of being prevented from contacting a condenser lens of an inverted microscope to which the main unit is attached, a second requirement of providing a region in which a distal end of the support unit is recognized, a third requirement of being prevented from contacting a sidewall of a dish for holding the object, and a fourth requirement of providing a region in which the dish moves relative to the tip unit. | 2010-09-30 |
20100248342 | TIP DRIVE APPARATUS AND CANTILEVER TIP - A tip drive apparatus is capable to moving a tip unit toward an object, while holding the tip unit at a prescribed angle. The tip unit is formed on a support unit having flexibility and directed to the object at the prescribed angle. The tip unit includes a contact side in a cross section including the distal end of the support unit and extending in the direction the support unit extends, the contact side configured to contact, at one part at least, the object, and to apply a prescribed pressure to the object. The tip unit further includes a first region including the contact side, and a second region continuous to the support unit. | 2010-09-30 |
20100248343 | Methods and Devices for Charged Molecule Manipulation - Devices and methods for constraining or holding a cell are provided. In one aspect, for example, a cellular constraint device is provided. Such a device can include a support surface and at least one constraining arm movably coupled to the support surface. The constraining arm has a first position in which the constraining arm is substantially parallel and substantially adjacent to the support surface. Additionally, at least a portion of the constraining arm is movable away from the support surface to a second position where the constraining arm is operable to constrain a single cell. | 2010-09-30 |
20100248344 | Methanogenic reactor - A methanogenic reactor for the production of methane, cellular biomass and other useful products for use in the manufacturing of specialty chemicals. The methanogenic reactor includes a bottom wall, perimeter wall, and top wall defining an interior space environmentally separable from an exterior space outside of the reactor vessel for holding a methanogenic culture and growth media. The reactor also includes at least one sparger positioned substantially within the interior space for facilitating the direction of an input gas stream into the reactor to be brought into contact with the methanogenic culture. The reactor also includes an output material stream port for releasing an output material stream created at least in part by the methanogenic culture. | 2010-09-30 |
20100248345 | PARTICLE FACILITATED TESTING - Magnetic particles are distributed across a fluid flow by applied magnetic field to interact with a test substance in fluid. Alternatively or additionally, particles, which may be magnetic, are combined with cells and energy, e.g. ultrasonic energy, is applied to cause the particles to create a lysate. Alternatively or additionally, the size of a quantity of magnetic particles is assessed by its impact on the tuning mechanism of a controlled oscillator that is affected by the particles. | 2010-09-30 |
20100248346 | ANALYZER - An analyzer comprising: a housing comprising a first space therein; a reagent accommodation section, disposed in the housing, comprising a second space therein for accommodating a reagent container containing a reagent, and an air induction port for inducting air from the first space to the second space; and a cooler for cooling the air which has been inducted from the first space through the air induction port into the second space, is disclosed. | 2010-09-30 |
20100248347 | DIAGNOSTIC SUPPORT APPARATUS FOR RENAL DISEASE AND COMPUTER PROGRAM PRODUCT - The present invention is to present a diagnostic support apparatus for renal disease, comprising: a red blood cell information obtainer for obtaining at least one of red blood cell numerical information representing the number of red blood cells in a urine sample, and red blood cell morphological information representing morphology of the red blood cells in the urine sample; a quantitative value information obtainer for obtaining at least one of quantitative value information representing amount of protein component in the urine sample, and quantitative value information representing amount of lipid component in the urine sample; and a diagnostic support information output unit for outputting diagnostic support information related to renal disease based on information obtained by the red blood cell information obtainer and information obtained by the quantitative value information obtainer. | 2010-09-30 |
20100248348 | TARGET NUCLEIC ACID MEASURING APPARATUS - The present invention relates to calculation of an amount equivalent to an initial template amount in a test sample by fitting a theoretical expression to an amount equivalent to an amplification amount of target nucleic acid for each thermal cycle number, wherein the theoretical expression includes an environmental coefficient as an exponent parameter and a parameter of the amount equivalent to the initial template amount, and includes at least one parameter among an amount equivalent to a saturation amount upon the target nucleic acid amplification, a reaction acceleration coefficient, and a reaction inhibition coefficient. | 2010-09-30 |
20100248349 | ANIMAL BLOOD CELL MEASURING APPARATUS - An animal blood cell measuring apparatus comprising: a specimen preparation section for preparing a measurement specimen from blood of an animal; a characteristic information obtaining section for obtaining characteristic information indicating a characteristic of the measurement specimen, from the measurement specimen prepared by the specimen preparation section; and a controller configured for performing operations comprising: (a) classifying aggregate reticulocytes contained in the blood from other blood cells, based on the characteristic information obtained by the characteristic information obtaining section; and (b) outputting information regarding a number of the classified aggregate reticulocytes. | 2010-09-30 |