39th week of 2008 patent applcation highlights part 47 |
Patent application number | Title | Published |
20080234079 | ARROWHEAD HAVING BOTH FIXED AND MECHANICALLY EXPANDABLE BLADES - An improved arrowhead features two sets of expandable blades. The expandable blades are pivotally movable from a first, concealed position to a second expanded position when spurs on the front of the blades contact a target. The first concealed position of the blades allows the arrowhead to penetrate the target upon contact. The fixed blades may be diamond-shaped, double-edged replaceable blades. The expandable blades comprise at least two pivotable blades that can be held in the first safe position by an elastic band. The spurs are located at a first end of the expandable blades, and these spurs are located proximate the base of the fixed blade portion of the arrow head, to allow the fixed portion to penetrate the target before the expandable blades are deployed by the spurs contacting the target. | 2008-09-25 |
20080234080 | Motorcycle wheel isolator - A motorcycle wheel isolator comprising a first sprocket member, the first sprocket member having a first projecting member, a second hub member, the second hub member having a second projecting member, at least one first projecting member disposed between two second projecting members, whereby a receiving portion is defined, at least one resilient isolator having a first portion and a second portion connected by a connecting member, the resilient isolator disposed in the receiving portion, an edge of each first portion and second portion having a chamfer disposed adjacent either the first projecting member or second projecting member, each first portion and second portion having a projecting member disposed on an outer surface of each first portion and second portion such that a compressive force applied to the first portion and second portion causes a bending mode in each first portion and second portion, and each first portion and second portion having a relief portion disposed on an outer surface of each first portion and second portion such that the first portion and second portion may expand under the compressive force. | 2008-09-25 |
20080234081 | Pretension loading method for power transmission chain and pretension loading apparatus - There is provided a pretension loading method for a power transmission chain, in which a chain with an endless loop shape having a plurality of laminated link plates bendably connected to each other by pin members is wound around a plurality of rollers and the chain is endlessly rotated while a load is loaded on the chain so as to load pretension on the chain, the method including the steps of: (a) maintaining the chain in a substantial tension state without a slack by controlling tension of at least one of the plurality of rollers while endlessly rotating the chain; (b) measuring a length of the chain in the tension state; (c) stretching the chain to a target length by controlling a displacement of the at least one of the rollers; (d) maintaining the chain in a substantial tension state without a slack by controlling tension of the at least one of the rollers; and (e) measuring the length of the chain in the tension state. At this time, the steps (c) to (e) are repeated until a difference between the target length and the length of the chain which is measured in the step (e) is less than a predetermined value. | 2008-09-25 |
20080234082 | Bicycle Multi-Gear Cassette - A bicycle multi-gear cassette mountable to a wheel hub that generally includes a truncated conical shell and a plurality of toothed sprockets having different numbers of teeth. The shell includes a plurality of coaxial annular cylinders of variable diameter extending along an axis of the shell and a plurality of coaxial annular discs of variable diameter extending radially of the axis. The cylinders and discs are alternatingly arranged in a stepped sequence. The toothed sprockets are disposed on the shell and extend radially of the shell axis. At least one of the toothed sprockets includes a recess on a side facing an adjacent toothed sprocket having a smaller number of teeth. The recess includes a first region having a first depth and a second region having a second depth. The first depth is greater than the second depth. The shell and the plurality of toothed sprockets embody a single piece. | 2008-09-25 |
20080234083 | Tensioner - A tensioner comprising a shaft ( | 2008-09-25 |
20080234084 | WHEEL WITH FLOATING SLEEVE - A wheel, such as a pulley or a sprocket, includes a hub and a sleeve. The hub has an outer surface with a plurality of substantially axially aligned teeth. The sleeve has: (a) an inner surface with a plurality of substantially axially aligned grooves that engage the teeth of the hub; and, (b) an outer band engagement surface that engages a band, such as a belt or a chain. As the band tends to become misaligned with respect to the wheel, the sleeve automatically moves axially with respect to the hub to correct the misalignment. | 2008-09-25 |
20080234085 | BELT, BELT GUIDE AND IMAGE FORMING APPARATUS HAVING THE SAME - A belt guide and an image forming apparatus having the same are disclosed. The image forming apparatus includes a belt supported by supporting rollers and circulates endlessly. A belt guide is disposed on contact portions between the belt and each of the supporting rollers to prevent a separation of the belt from the supporting rollers. The belt guide is formed in a multi-step concave-convex shape, e.g., a staircase-like shape or a square wave shape. Accordingly, a contact area between the belt and the supporting roller is maximized, thereby effectively preventing wear, separation and color mis-registration of the belt due to meandering thereof. | 2008-09-25 |
20080234086 | CYLINDRICAL ROLLER-INCORPORATED ROLLER CHAIN - A cylindrical roller-incorporated roller chain, which can reduce wear of the side plates and also can reduce radial wear. A roller chain for a conveyor in which a plurality of cylindrical rollers are composed of either a casehardened steel cylindrical roller | 2008-09-25 |
20080234087 | Power Transmission Device and Process Implementing Such Device - The present invention concerns essentially a power transmission device ( | 2008-09-25 |
20080234088 | STEP AUTOMATIC TRANSMISSION - An automatic transmission of a motor vehicle, comprising a plurality of planetary gear units; a plurality of frictional elements, the frictional elements assuming engaged/disengaged condition upon receiving a ratio change instruction thereby to establish a desired speed of the transmission with the aid of the planetary gear units; a deceleration detecting means that detects a deceleration of the motor vehicle; a gear ratio detecting means that detects an actual gear ratio that is actually established in the transmission; and an interlock judgment means that judges whether or not the transmission is subjected to an interlock, the interlock being a condition wherein upon receiving the ratio change instruction, at least one of the frictional elements is brought into unintended engagement. The interlock judgment means is configured to carry out judgment of the interlock by analyzing a deceleration of the vehicle and a relation between a gear ratio intended by the ratio change instruction and an actual gear ratio actually established by the transmission while the transmission is not under a ratio change. | 2008-09-25 |
20080234089 | DRIVE UNIT FOR CONTINUOUSLY VARIABLE ROTATIONAL SPEED CONTROL AND ITS USE - A drive unit ( | 2008-09-25 |
20080234090 | MULTIPLE GEAR TRANSMISSION WITH MAGNETIC CONTROL - A multiple gear transmission with magnetic control for vehicles or for use in drive technology includes an input shaft supported on a frame and an output shaft. The input shaft protrudes from the frame at least one end and the output shaft protrudes from the frame at one end. Transmission gear ratios with transmission wheels are embodied as gear trains or belt and chain drives and are located between the input shaft and the output shaft. Transmission wheels are supported in a rotatable manner on the input shaft or on the output shaft. The transmission wheels are connected to the input shaft or the output shaft in a torsionally fixed manner by a clutch mechanism. The transmission wheels are constantly in rotation during operation. At least one component is supported in a rotatable or displaceable manner relative to a toothing within the clutch mechanism. At t least one component adopts a positive position in the toothing within the clutch mechanism. At least one component adopts a position at a distance relative to the toothing within the clutch mechanism. At least one component within the clutch mechanism has properties of a permanent magnet with a magnetic north and south pole within a magnetic field. A state of the clutch mechanism changes through the change of an additional magnetic field inside or in a direct vicinity of the clutch mechanism. During at least one shifting operation the state of at least two clutch mechanisms changes simultaneously. At least one of the clutch mechanisms transfers only torque in one direction of rotation. | 2008-09-25 |
20080234091 | Transfer Case with Overdrive Mode - A transfer case includes an input shaft and first and second output shafts. An overdrive unit is driven at an increased speed relative to the input shaft. A clutch is operable in a first position to establish a drive connection between the input shaft and the first output shaft. The clutch is further operable in a second position to establish a drive connection between the overdrive unit and the first output shaft. An actuator is driven by a motor for moving the clutch between its first and second positions. The actuator includes an axially movable fixed disk fixed for rotation with an output member of the overdrive unit. The shift engages an axially movable sleeve of the clutch. | 2008-09-25 |
20080234092 | Gear Transmission - A gear transmission comprises a traveling load detection means including an upstream detection member, a downstream detection member and a biasing member. One of the upstream and downstream detection members is an axially slidable detection member which is axially slidable along an output shaft. One of the upstream and downstream detection members has a first engagement part and a second engagement part. The first engagement part and the second engagement part generate respective forces for sliding the axially slidable detection member opposite to the biasing direction of the biasing member. The forces are changed according to variation of the traveling load. | 2008-09-25 |
20080234093 | Multi-Speed Gearbox - The eight-gear transmission comprises an input shaft (AN), an output shaft (AB), four planetary gearsets (RS | 2008-09-25 |
20080234094 | Transistor-Type Universal Driving - The present invention relates to the transistor type universal driving which has three shafts as transistor, i.e. driving shaft, driven shaft and control shaft and can provide non-step speed reduction, non-step speed increase, overloading adaptation control, automatic and remote control. The structural character of the transistor type universal driving is that the control shaft is suitably combined to the fixed support point of the speed reducer which contains the fixed support point. | 2008-09-25 |
20080234095 | Planetary Gear - When, according to the invention, a one-stage planetary gear is constructed with radially resilient planet wheels and sun shaft ( | 2008-09-25 |
20080234096 | Hybrid Utility Vehicle - A serial hybrid drive system for off-road utility vehicles and/or riding tractors including one or more electric motors ( | 2008-09-25 |
20080234097 | CLUTCH CONTROL FOR HYBRID TRANSMISSION - A method and system to off-load motive torque from a clutch to execute a transmission shift is provided. The powertrain includes torque-generative devices operably connected to a two-mode, compound-split, hybrid electro-mechanical transmission. The method includes determining a commanded output torque, and a shift command. A first torque is transmitted by electrical motors, and is limited by their torque capacities. A supplemental motive torque is transmitted from an oncoming clutch. The supplemental motive torque is limited by a torque capacity of the oncoming clutch. Output torque of an internal combustion engine to the transmission is adjusted by an amount substantially equal to a difference between the commanded output torque and the first and the supplemental motive torques. | 2008-09-25 |
20080234098 | METHOD OF OPERATING A HYBRID DRIVE SYSTEM AND HYBRID DRIVE SYSTEM WITH TWO PARTIAL DRIVES - A method of operating a hybrid drive system with a main driving machine | 2008-09-25 |
20080234099 | Control Valve Assembly for Controlling a Starting Clutch of an Automatic Transmission - The invention involves a control valve arrangement to activate at least one start-up clutch of a motor vehicle automatic transmission with at least one clutch control valve ( | 2008-09-25 |
20080234100 | Control Valve Arrangement for Controlling a Starting Clutch of an Automatic Transmission - A control valve arrangement having a clutch regulation valve ( | 2008-09-25 |
20080234101 | Driving force distribution apparatus - A friction clutch which transmits motive power of a main drive shaft to an auxiliary drive shaft, a piston which generates pressing force against the friction clutch, a cylinder chamber which houses the piston movably in the axial direction, a pressure sensor which detects the oil pressure of the cylinder chamber, an hydraulic pump which feeds pressurized oil to the cylinder chamber, a motor which drive the hydraulic pump forward/reversely, and a controller which compares a command from a vehicle with a signal from the pressure sensor and controls the forward/reverse drive of the motor are provided. An hydraulic control valve unit feeds the pressurized oil to the cylinder chamber when the hydraulic pump is rotated forward, prevents outflow of the pressurized oil from the cylinder chamber when forward rotation of the hydraulic pump is stopped, and forcibly discharges the pressurized oil from the cylinder chamber when the hydraulic pump is reversely rotated. | 2008-09-25 |
20080234102 | Method and Arrangement For Adapting Shifting Strategies in a Heavy Vehicle Including an Automated Transmission and Experiencing a Pto Load - Method and arrangement for adjusting shift characteristics of a transmission of a heavy vehicle. A heavy vehicle is operated and that is powered by an internal combustion engine equipped with an automated manual transmission and a power take off. The power take off, when operating, imposes a torque-consuming load on the engine. Operation of the power take off is detected when the engine of the vehicle is in a power mode. At least one gear-shift event is adapted to occur at a higher engine speed when power take off operation is detected than when power take off operation is not detected. The gear-shift event is affected at an engine speed that is approximately five to twenty-five percent higher than when power take off operation is not detected. The gear-shift event may be an up-shift to a lower ratio gear engagement or a down-shift to a higher ratio gear engagement. | 2008-09-25 |
20080234103 | FUEL QUALITY INDICATION FOR ADAPTIVE TRANSMISSION CONTROL - A control system and method for adaptively controlling transmission ratio shifting in an electronically controlled transmission. A refueling event is detected. After the detected refueling event, fuel consumption is monitored for a predetermined period during which a change in composition of fuel to the engine reaches or approaches a steady state. During the period, the rate of adapting transmission shift controls is modified to respond quicker to the change in shift characteristics induced by differences in torque produced by the engine. Implementing this method can improve transmission shift quality while the quality of fuel reaching an engine is in transition. | 2008-09-25 |
20080234104 | Method and Device For Controlling Engine Torque and Speed - A method and device for modifying throttle control characteristics of a throttle control in a vehicle, the vehicle including an engine coupled to engine driven vehicle wheels via a stepped gear mechanical transmission, and where requested engine torque at a given engine speed of the engine is controlled as a function of positions of the throttle control. When sensing a gear shift to a vehicle high speed gear, a control unit modifies the characteristics so the engine torque and engine speed will be controlled via said throttle control along a first set of relatively flat curves, when the curves are plotted in a diagram with engine torque on the y-axis and engine speed on the x-axis. When sensing a gear shift to a vehicle low speed gear, the characteristics are modified so the engine torque and engine speed will be controlled via the throttle control along a second set of curves that are steeper than the first set of curves, so that when driving with a vehicle low speed and for a certain change in engine speed, a greater change in torque will be provided than when controlling is done in accordance with the first set of curves. | 2008-09-25 |
20080234105 | Control System and Method for Automatic Transmission - A worsening of drivability is to be kept to a minimum by making a fail-safe control taking the state in the event of failure of a shifting operation into account. When clamping a sleeve to a free rotatable gear and during the period after instructing movement of the sleeve to a clamping position until movement of the sleeve to a predetermined positional range which makes it possible to judge that the sleeve has been clamped to the free rotatable gear, a pushing load for the sleeve is increased if the sleeve is in a fixed state near the balk ring, while if the sleeve is in a fixed state near the free rotatable gear, the sleeve is once returned to a neutral position thereof and is re-clamped to the free rotatable gear. Further, the number of times the sleeve is re-clamped to the free rotatable gear is counted and the use of the free rotatable gear is inhibited in accordance with the counted number of times. | 2008-09-25 |
20080234106 | ENGINE CONTROL FOR DISPLACEMENT ON DEMAND - An engine control system for controlling a displacement on demand engine having a plurality of cylinders includes a torque converter with a torque converter clutch. A control module determines a slip speed of said torque converter clutch, estimates a temperature state of said torque converter clutch based on said slip speed, and selectively activates at least one of said cylinders based on said temperature state. | 2008-09-25 |
20080234107 | Electrical Signature Analysis to Quantify Human and Animal Performance on Fitness and Therapy Equipment such as a Treadmill - The invention is a human and animal performance data acquisition, analysis, and diagnostic system for fitness and therapy devices having an interface box removably disposed on incoming power wiring to a fitness and therapy device, at least one current transducer removably disposed on said interface box for sensing current signals to said fitness and therapy device, and a means for analyzing, displaying, and reporting said current signals to determine human and animal performance on said device using measurable parameters. | 2008-09-25 |
20080234108 | OBSTACLE SUPPORTER HAVING A VARIABLE SIZE - An obstacle supporter for an obstacle assembly. The obstacle supporter includes: (a) a body which is at least partially flexible; and (b) a body support coupled to the body and which is adjustable between a plurality of different sizes. The obstacle supporter is convertible between a larger size for a use-mode and a relatively compact size for a non-use mode. Two or more obstacle supporters can be spaced apart to support an obstacle therebetween. | 2008-09-25 |
20080234109 | CLIMBER - “The Climber” belongs to the fitness equipment category. However, this equipment designed for improving children fitness. It is different from the adult fitness equipment in size, easy portability, easy exercising and easy accessibility. Also, it provides light exercise for the arms and legs of the children in the same time. Presently, no such children-fitness equipments exist or in use. A magnetic rotation counter can be added to the equipment, competition between the children can be set up and individual accomplishment can be measured with it. | 2008-09-25 |
20080234110 | EXERCISE MACHINE WITH PIVOTING USER SUPPORT HAVING MULTIPLE PIVOT LINKAGE - An exercise machine has a main frame, a user support frame which supports a user in an exercise position, and a multiple pivot assembly pivotally mounting the user support frame for movement between a start position and an end position. The pivot assembly has multiple pivots which define a theoretical pivot axis of the user support pivotal movement and a vertical gravitational center line which extends through the theoretical pivot axis. The user support frame has at least a primary support and a secondary support for supporting spaced positions on a user's body throughout an exercise movement. A user engagement device is movably mounted relative to the frames for engagement by the user in performing exercises, and a multiple part connecting linkage translates movement of the user engagement device to rotational movement of the user support frame. A load resists movement of at least one of the user support, user engagement device, and connecting linkage. | 2008-09-25 |
20080234111 | Mid-deck hinged treadmill deck - This Mid-deck Hinged Treadmill Deck allows the deck of a treadmill to fold into small spaces which is useful to any use where space is limited. A few examples of such uses or applications are treadmills that fold under desk tops or treadmills that fold into furniture or treadmills that fold out of wall fixtures. The smaller volume required to box, ship and store a Mid-deck Hinged Treadmill also lowers freight and storage costs simply because more units will fit into a shipping container or warehouse space. To function properly the Mid-deck Hinged Treadmill Deck requires a rear mechanism that loosens the rear roller when it is being folded or unfolded and then locks or tightens the rear treadmill roller when it is used. | 2008-09-25 |
20080234112 | BICYCLE MOUNTED EXERCISE AND TRAINING DEVICE - A bicycle trainer is a bicycle-mounted apparatus used to produce friction to resist the turning of a wheel of a bicycle, thereby requiring the rider to exert more energy than would otherwise be necessary. The bicycle trainer is adjustable by the rider while riding, and can simulate hill or mountain climbing at any positive grade. | 2008-09-25 |
20080234113 | Gait Rehabilitation Methods and Apparatuses - A method for gait rehabilitation, comprising, identifying at least one deficient gait element; exercising said deficient gait element individually using a rehabilitation apparatus; and exercising said deficient gait element in concert with at least one other gait element using said rehabilitation apparatus. | 2008-09-25 |
20080234114 | Athletic belt and clips for securing a workout towel - A velcro athletic belt with velcro backed clips for securing a workout towel to the torso of a person. This “hands free” belt, clip and towel assembly allows the person to exercise, jog, run or lounge with the towel securely attached on his waist. A different embodiment utilizes clips which attach the towel directly to the person's clothes. | 2008-09-25 |
20080234115 | EXERCISE MACHINE - An exercise machine for exercising the muscles of the upper body, in which a pushing or pulling movement can be performed in a direction approximately between horizontal and vertical towards or away from the shoulder joint of the user, with the user seated in the same position. | 2008-09-25 |
20080234116 | EXERCISE SYSTEM AND METHOD FOR ITS USE - An exercise system includes at least a first and second pivot pole assembly for supporting and stabilizing a person engaged in exercise. The pivot pole assemblies each include a base plate which is configured to rest on a floor during the use of the system, and a pole portion which is pivotally connected to the base portion by a universal joint. The assemblies may be configured so as to be connectable to one another, and such connection may be achieved through the bases and/or the poles. The system may incorporate weights attachable to the poles and/or may utilize compressible poles to provide an enhanced effect. Further disclosed are exercise programs incorporating the systems. | 2008-09-25 |
20080234117 | MODULAR EXERCISE PLATFORM - An exercise platform may include: (A) a base having a base cavity; (B) an insert that: (1) is sized to be stably received within the base cavity; and, (2) has an insert cavity; and, (C) another insert sized to be stably received within the insert cavity. The base cavity may also be sized to stably receive the base of a balance trainer and the insert cavity may also be sized to stably receive a portion of a stability ball. | 2008-09-25 |
20080234118 | Sheet folding apparatus | 2008-09-25 |
20080234119 | SERVO-DRIVEN FORMING PRESS - A forming apparatus for producing paperboard pressware includes servo-driven blanking and product forming subsystems, and a computerized control system to provide independent control of the servo-driven subsystems for improved timing and positional accuracy. Independent and individual electronic control of the various component subsystem enables remote control and monitoring of production and machine functions. | 2008-09-25 |
20080234120 | APPARATUS AND METHODS FOR NON-CONTACT ADHESIVE DISPENSING TO MANUFACTURE BAGS - Various methods of forming bags include applying hot melt adhesive to material without contacting the material with the dispenser that applies the adhesive. The material may be provided in various forms, such as elongate sheet material dispensed from a roll, or elongate tube material that is flattened to define first and second oppositely disposed sidewalls, for example. The material may be provided in single plies, multiple plies, or as separate sheets that are cut, folded, or otherwise manipulated to form bags, with the adhesive joining selected portions of the bag. A nozzle for dispensing hot melt adhesive includes an air passage that is inclined in a direction toward a liquid outlet. The air passage communicates with an air outlet disposed in a common plane with the liquid outlet. | 2008-09-25 |
20080234121 | Automatic Balancing Centrifugal Apparatus By Fluid Compsensation - The invention relates to an automatic balancing centrifugal apparatus by fluid compensation, which compensates a load imbalance among buckets holding samples by injecting a fluid into the buckets or sucking the fluid from the buckets, thereby simplifying the overall structure of the centrifugal apparatus, increasing the durability, and centrifuging a large quantity of samples under various high-speed rotation conditions smoothly. The automatic balancing centrifugal apparatus by fluid compensation comprises: rotors on which a plurality of buckets are mounted; a centrifuge motor for rotating said rotors; a load measurement mechanism, which is installed so as to lift and lower along the rotation trace of said buckets and which measures the load of said buckets while the restraint of the buckets is being released at the time of lifting; a position sensing mechanism for sensing whether or not each of said buckets is positioned right above said load measurement mechanism; a fluid compensation mechanism for injecting a fluid into said buckets or for sucking the fluid from the buckets; and a main control part for controlling the overall operations of each of said elements and for controlling said fluid compensation mechanism so that the loads of said buckets can become equal to each other. | 2008-09-25 |
20080234122 | A SINTERED REFACTORY MATERIAL BASED ON SILICON CARBIDE WITH A SILICON NITRIDE BINDER - A sintered material based on silicon carbide (SiC) reactively sintered between 1,100° C. and 1,700° C. to form a silicon nitride binder (Si | 2008-09-25 |
20080234123 | Refractory material for reduced SiO2 content - A refractory material used in refractory furnace liners, combustion chambers, baffles and artificial fire logs includes alumina silicate; an additive comprising at least one of silicon carbide, silicon nitride, boron carbide, boron nitride and silicon carbo-nitride; and a binder. The refractory material is light weight, has a high noise reduction capacity, is fire resistant and has a reduced silica content. In a most preferred embodiment, the additive makes up 50.0% to 55.0% of the material by weight, the binder makes up 4.5% to 5.0% of the material by weight and the linear shrinkage of the material is no greater than 3.5% at 2600° F. A preferred binder is colloidal silica although many others are suitable. Preferably, the material is free of cellulose fiber and sodium silicate. | 2008-09-25 |
20080234124 | Apparatus and method for steaming treatment of molecular sieves - An apparatus for treatment of a plurality of molecular sieves samples is described. The apparatus comprises a steam preparation section, a steam reactor section, and a steam collection section. The steam preparation section includes a steam generator, and a means to supply inert gas into the steam reactor section. The steam reactor section includes a plurality of sample holders. The steam collection section includes a plurality of knock-out vessels. The steam reactor section is operatively connected to the steam preparation section, and the steam collection section is operatively connected to the steam reactor section. In one embodiment, each sample holder is connected and operated in tandem with one knock-out vessel. A process for treating a plurality of molecular sieves samples with steam is also disclosed which may be carried out with the described apparatus. | 2008-09-25 |
20080234125 | Catalysts and processes for selective hydrogenation of acetylene and dienes in light olefin feedstreams - A catalyst and a method for selective hydrogenation of acetylene and dienes in light olefin feedstreams are provided. The catalyst retains higher activity and selectivity after regeneration than conventional selective hydrogenation catalysts. The catalyst contains a first component and a second component supported on an inorganic support. The inorganic support contains at least one salt or oxide of zirconium, a lanthanide, or an alkaline earth. | 2008-09-25 |
20080234126 | Method for preparing vanadium/titania-based catalyst for removing nitrogen oxide at low temperature - Disclosed is a method of preparing a vanadium/titania-based catalyst containing non-stoichiometric vanadium and titanium having excellent ability to remove nitrogen oxides at a wide temperature window, particularly, at a relatively low temperature window of 300° C. or lower. | 2008-09-25 |
20080234127 | Systems and methods for printing borderless images on printable media - A system of printing borderless images on printable media includes at least one sheet of printable media including an imaging surface and a non-imaging surface. The system further includes a removable extension strip having a front surface with an adhesive zone and a non-adhesive zone, a non-adhesive back surface, and a straight line of demarkation between the adhesive and non-adhesive zones. The adhesive zone is configured to removably adhere to the non-imaging surface, and the straight line of demarkation is configured as a placement guide for adhering the adhesive zone of the extension strip to the media. An associated method includes adhering an adhesive portion of removable extension strip to a non-imaging surface proximate a trailing edge of the media, and ink-jet printing an image on an imaging surface of the media using an ink-jet printer. The strip is used by rollers in the printer to advance the media. | 2008-09-25 |
20080234128 | HEAT-SENSITIVE RECORDING MATERIAL - To provide a heat-sensitive recording material including a substrate; a heat-sensitive color-developing layer over the substrate, the heat-sensitive color-developing layer containing a leuco dye and a developer; a first protective layer over the heat-sensitive color-developing layer, the first protective layer containing a water-soluble resin and a crosslinking agent; and a second protective layer over the first protective layer, the second protective layer containing a water-soluble resin, a crosslinking agent and a pigment, wherein the heat-sensitive color-developing layer, the first protective layer and the second protective layer are formed simultaneously by curtain coating method, and the second protective layer contains diacetone-modified polyvinyl alcohol and acrylic resin or maleic acid copolymer resin. | 2008-09-25 |
20080234129 | Lignin-based microparticles for the controlled release of agricultural actives - A method of producing lignin-based matrix microparticles for the controlled release of an agricultural active includes forming an emulsion of an organic solution in an aqueous solution, wherein the organic solution contains a lignin derivative and an agricultural active in a volatile organic solvent and the aqueous solution contains an emulsifier; and removing the organic solvent, thereby producing microparticles having a matrix comprising the lignin derivative within which the agricultural active is distributed. Small, spherical lignin-based matrix microparticles that release an agricultural active at a controlled rate are described, as are plants and plant propagation materials that are treated with such microparticles. | 2008-09-25 |
20080234130 | Compositions providing tolerance to multiple herbicides and methods of use thereof - Methods and compositions are provided related to improved plants that are tolerant to more than one herbicide. Particularly, the invention provides plants that are tolerant of glyphosate and are tolerant to at least one ALS inhibitor, and methods of use thereof. The glyphosate/ALS inhibitor-tolerant plants comprise a polynucleotide that encodes a polypeptide that confers tolerance to glyphosate and a polynucleotide that encodes an ALS inhibitor-tolerant polypeptide. In specific embodiments, a plant of the invention expresses a GAT polypeptide and an HRA polypeptide. Methods to control weeds, improve plant yield, and increase transformation efficiencies are provided. | 2008-09-25 |
20080234131 | Herbicidal Mixtures of Cinmethylin - A herbicidal mixture comprising A) exo(+)-1 -methyl-4-(1-methylethyl)-2-[(2-methylphenyl)methoxy]-7-oxabicyclo[2.2.1]heptane (Common Name Cinmethylin) including its respective isomers and B) at least one herbicidal compound of the group of dinitro anilines of formula (I) in which the substituents have the following meanings R1 C | 2008-09-25 |
20080234132 | Microcin B17 Analogs And Methods For Their Preparation And Use - The present invention pertains to synthetic analogues of microcin B17 component units, methods of making and using these analogues, including, for example, as inhibitors of DNA gyrase. More particularly, the present invention pertains to compounds of the Formula wherein: W is independently: —H or a peptide group; Z is independently: —OH or a peptide group; wherein each peptide group, if present, is: an amino acid group and comprises exactly one amino acid, or: a poly(amino acid) group and comprises two or more amino acids; R | 2008-09-25 |
20080234133 | Plant activator - An object of the present invention is to determine novel means of activating plants; more particularly, means of controlling plant growth, such as means of promoting growth, means of controlling dormancy, means of imparting tolerance against stress for plants (dryness, high or low temperatures, osmotic pressure, etc.), and means of preventing aging. The present inventors have found that the above object can be achieved by providing plant activators containing, as an active ingredient, C | 2008-09-25 |
20080234134 | Buffer layers for coated conductors - A composite structure is provided including a base substrate, an IBAD oriented material upon the base substrate, and a cubic metal oxide material selected from the group consisting of rare earth zirconates and rare earth hafnates upon the IBAD oriented material. Additionally, an article is provided including a base substrate, an IBAD oriented material upon the base substrate, a cubic metal oxide material selected from the group consisting of rare earth zirconates and rare earth hafnates upon the IBAD oriented material, and a thick film upon the cubic metal oxide material. Finally, a superconducting article is provided including a base substrate, an IBAD oriented material upon the base substrate, a cubic metal oxide material selected from the group consisting of rare earth zirconates and rare earth hafnates upon the IBAD oriented material, and an yttrium barium copper oxide material upon the cubic metal oxide material. | 2008-09-25 |
20080234135 | LIGAND IDENTIFICATION AND MATCHING SOFTWARE TOOLS - Using annotated structural descriptions and binding data for two, four or more input ligand molecules known to bind to a given protein target, a profile of the ligand molecules can be created by identifying patches of ligand molecules which have similar chemical and/or stereochemical descriptions, scored with the use of a weight dataset (e.g., substitution matrix). A database containing annotated molecular descriptions can be searched according to the profile to identify, for example, additional ligands that can bind to the protein target. Information such as the input ligands, the additional ligands, and literature related to these molecules, and modeling tools can be displayed in a user interface. | 2008-09-25 |
20080234136 | Single molecule arrays for genetic and chemical analysis - Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm | 2008-09-25 |
20080234137 | Assay Method for Group Transfer Reactions - The present invention relates to methods for detecting, quantifying and high throughput screening of donor-products and the catalytic activities generating the donor-products in group-transfer reactions. The invention further provides immunoassays, antibodies and kits that may be used to practice the methods of the invention. | 2008-09-25 |
20080234138 | TP53 gene expression and uses thereof - The present invention is drawn to diagnosis, prognosis and treatment of multiple myeloma. In this regard, the present invention discloses importance of down-regulation of TP3 gene in multiple myeloma and its use as an independent progostic indicator of multiple myeloma. Additionally, the present invention also discloses novel-TP53 associated genes and demonstrates the clinical relevance of these alterations to disease progression. | 2008-09-25 |
20080234139 | Diagnosis, prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling - Provided herein are methods for diagnosing and treating multiple myeloma based on statistical analysis of and subsequent increasing/inhibiting expression of subgroups of plasma cells and B cell genes. Also provided are methods for a developmental stage-based classification for multiple myeloma using hierarchical clustering analysis of plasma cell and B cell nucleic acids and for discriminating among normal, hyperplastic and malignant using gene expression array data and statistical analysis thereof. In addition methods for determining the risk of developing bone disease in a test individual by examining expression levels of a WNT signaling antagonist, such as DKK1, are provided. A kit comprising anti-DKK1 antibodies and detection reagents for measuring DKK1 protein levels also is provided. | 2008-09-25 |
20080234140 | Method and Device for Applying a Plurality of Microdroplets on a Substrate - The invention relates to a device for applying a plurality of microdroplets to a substrate ( | 2008-09-25 |
20080234141 | GENERATION OF COMPOUND LIBRARIES UTILIZING MOLECULAR IMPRINTS INCLUDING A DOUBLE OR ANTI-IDIOTYPIC APPROACH - The present invention relates to a method of producing new chemical entities comprising the steps of: (i) taking a chemical entity as the template to prepare a molecularly imprinted polymer (MIP), (ii) removing the template from the MIP, (iii) using the specific binding sites of the MIP to direct, or facilitate, the syntheses of new chemical entities for the generation of compound libraries using molecularly imprinted polymers, and to a use of such compound libraries. | 2008-09-25 |
20080234142 | Random Mutagenesis And Amplification Of Nucleic Acid - A method is provided for mutagenizing nucleic acids and proteins relative to an initial nucleic acid sequence by the insertion, deletion or substitution of nucleotide(s) in the target nucleic acid during amplification. | 2008-09-25 |
20080234143 | Mechanical methods for producing substrates having selectively immobilized molecules - Methods, systems and substrates for providing molecules of interest in selected regions of substrates for use in analytical operations. Methods employ mechanical methods of applying force for the removal of molecules of interest from other than the desired locations on a substrate. | 2008-09-25 |
20080234144 | Apparatus and method for digital magnetic beads analysis - A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be structured a series of alternating light transmissive and opaque sections, with relative positions, widths and spacing resembling a 1D or 2D bar code image. To decode the image, the alternating transmissive and opaque sections of the body are scanned in analogous fashion to bar code scanning. The coded bead may be coated or immobilized with a capture or probe to effect a desired bioassay. The coded bead may include a paramagnetic material. A bioanalysis system conducts high throughput bioanalysis using the coded bead, including a reaction detection zone and a decoding zone. Alternative method for barcode determination is based on barcode pattern image processes. Microbeads can also be settled down to the bottom of the well in a microplate, so the barcode can be decoded by image processed directly. Therefore, multiple-analyte tests can be performed in one single well. Microplate is a standard format; each plate can have 96, 384, or 1536 patient samples. The bead image is taken with a conventional microscope and optical detector from the bottom of an optically clear microplate, and barcode pattern can be decoded by image software. Therefore, the whole bead experiment can be performed in the microplate without taking the beads out. | 2008-09-25 |
20080234145 | Use of Lithium Salts of Fatty Alcohol Sulphates for Cleaning Boreholes, Boring Devices and Borings - The invention relates to the use of compounds of general formula (I): R—O—SO—Li | 2008-09-25 |
20080234146 | Proppant and Production Method Thereof - The invention relates to the oil-and-gas production industry and can be used for enhancement of the production of oilfield wells as it prevents the fracture from closing by pumping of propping granules (proppant) during the hydraulic fracturing of oil-producing formations. Higher stimulation of a reservoir through using hydraulic fracturing is provided with the proppant as particulate with spherical or elliptic form, made of ceramic, polymer, metal, or glass and having higher roughness than regular proppant, wherein the surface roughness is nonuniform and described by two criteria A and B, varying in the intervals: A=0.0085−0.85; B=0.001−1.0. The proppant manufacturing method comprising the preparation of raw material, mixing, granulation, drying, firing, wherein an additional stage of creation of surface roughness is added at the granulation stage and/or the firing stage. | 2008-09-25 |
20080234147 | Method of Treating Subterranean Formation with Crosslinked Polymer Fluid - A method of treating a subterranean formation penetrated by a wellbore utilizes a treating fluid formed from an aqueous solution of a water-soluble polymer. The treating fluid further contains a crosslinking agent and an optional delayed release alkaline additive. The delayed release alkaline additive may be at least one of urea, a urea derivative, a solid alkaline earth metal carbonate, a solid alkaline earth metal oxide and combinations of these. The treating fluid further includes an acidic pH adjusting agent used in an amount to provide the treating fluid with a pH of less than about 5. The treating fluid is then introduced into the formation. | 2008-09-25 |
20080234148 | Method of Increasing pH of High-Density Brines - It has been discovered that carbonate powders and bicarbonate powders are useful to increase the pH and corrosion resistance of high-density brines, such as zinc bromide brines, without significantly reducing their densities. The carbonates and/or bicarbonates should be water-soluble and may be sodium, potassium, magnesium and/or ammonium carbonates and/or bicarbonates and the like. The carbonates and/or bicarbonates are easily added in powder or other finely divided solid form and are completely dissolved in the brine prior to pumping the brine into a subterranean formation. | 2008-09-25 |
20080234149 | Nanoparticulate based lubricants - A method of making a nanoparticulate based lubricant is disclosed. The method includes providing solid lubricant material with particles having a size less than or equal to about 500 nanometers, and treating the particles to create composite nanoparticles. The composite nanoparticles includes the solid lubricant material and at least a second material. | 2008-09-25 |
20080234150 | GREASE COMPOSITION FOR CONSTANT VELOCITY JOINT AND CONSTANT VELOCITY JOINT - The invention provides a grease composition for constant velocity joint containing the components (a) to (g) below and a constant velocity joint containing said composition.
| 2008-09-25 |
20080234151 | Lubricating Oil Composition for Sizing Pressing - Provided is a lubricating oil composition for sizing excellent in machinability and rust preventing properties. A lubricating oil composition for sizing, including (A) a lubricating base oil having a kinematic viscosity of 0.5 to 150 mm | 2008-09-25 |
20080234152 | Alkyl Acetal Compound, Process for Producing the Same, and Lubricating Oil Composition - A compound which satisfies requirements for the annealing property and the lubricating property simultaneously and a process for producing the compound are provided. The compound is an alkylacetal compound represented by the following general formula (1) or (2). In the general formulae, R | 2008-09-25 |
20080234153 | LUBRICATING OIL COMPOSITION - The present invention provides a lubricating oil composition, which is capable to maintain sufficient low-friction (i.e. fuel saving performance) even when the lubricating oil is contaminated with soot and metal abrasion powder, which is excellent in durability with regard to anti-wear property and detergency, as well as oxidation stability, and which is capable to lower the ash content and to sufficiently maintain the performance of exhaust-gas after-treatment device for a long term. The lubricating oil composition comprises a lubricant base oil containing a base oil (X) of which % C | 2008-09-25 |
20080234154 | ORGANIC TUNGSTEN COMPLEXES - The present invention relates to lubricant compositions containing phosphorus and sulfur free organotungstates. The organotungstates are defined as either the reaction product of a mono- or diglyceride and a tungsten source, or as the reaction product of a secondary amine, a fatty acid derivative, and a tungsten source. These compositions exhibit improved antiwear, corrosion, and antioxidancy properties, particularly in low phosphorus and low sulfur environments. | 2008-09-25 |
20080234155 | Lubricant composition with improved electrical properties - A lubricant composition for improving electrical properties in lubricant systems to reduce the formation of sludge and varnish is disclosed. The lubricant composition comprises a base oil and an effective amount of antistatic additive to provide the composition with an electrical conductivity of at least about 50 pS/m at 25° C. and a dielectric strength of at least 300 V/mil. | 2008-09-25 |
20080234156 | Lubricant compositions with improved properties - A lubricant composition for providing friction reducing properties and VI and solvency improving properties in a lubricant system is disclosed. The lubricant composition comprises a major amount of at least one base oil and an effective amount of a high viscosity polyester additive having a kinematic viscosity at 100° C. of at least about 2,500 mm | 2008-09-25 |
20080234157 | Alkylaromatic lubricant fluids - The alkylaromatic compositions include an aromatic moiety other than unsubstituted naphthalene; and an alkyl moiety having a carbon atom number in the range between 12 to 40, wherein said alkyl moiety is attached to said aromatic moiety such that at least 25 mol % of the benzylic carbons are quaternary. The process for producing the alkylaromatic compositions include contacting at least one an aromatic compound and a mono-olefin having a carbon atom number in the range between 12 to 40 in the presence of an acidic alkylation catalyst under alkylation conditions, wherein at least 50 mol % of the mono-olefin structure comprises a vinylidenyl structure, and thereby producing said alkylaromatic compound having at least 25 mol % of benzylic carbons that are quaternary. The alkylaromatic compositions disclosed herein are liquids that have improved thermo- and oxidative stability and pour point. | 2008-09-25 |
20080234158 | Compositions counteracting pesticides and malodorants - This invention relates to compositions that counteract chemicals such as pesticides and malodorants. Also disclosed are a method for preparing such compositions and a method for applying such compositions to counteract pesticides or malordorants. | 2008-09-25 |
20080234159 | Novel Acylalkylisethionate Esters and Applications in Consumer Products - The present invention provides acylalkylisethionate esters useful in consumer products. The acylalkylisethionate esters are produced by reacting one or more carboxylic acids with one or more alkyl-substituted hydroxyalkyl sulfonates under esterification reaction conditions. The alkyl-substituted hydroxyalkyl sulfonates used as a raw material in producing the esters are prepared by reacting bisulfite with one or more alkylene oxides. | 2008-09-25 |
20080234160 | Color changing cleansing composition - A cleansing composition is disclosed that changes color during use. The cleansing composition contains a plurality of thermochromic dyes that cause a color change to occur at a threshold temperature and continue to cause a color change over a temperature range. The range of temperatures corresponds to approximately the amount of time sufficient to properly wash or scrub using the product. | 2008-09-25 |
20080234161 | Solid Detergent Bar - A method of preparing benefit agent-containing bar detergent, comprising plodding noodles of benefit agent-containing detergent material into bars, the noodles being characterised that at from 5-95% by weight of the noodles are coated with a film of a water-soluble polymeric material that softens on exposure to water and hardens again when that exposure is removed, the film being benefit agent-permeable when soft and benefit agent-impermeable when hard. The method is particularly effective at disguising the tendency to rancidity of soaps based on natural oils and fats, by the incorporation of fragrance as benefit agent. | 2008-09-25 |
20080234162 | SEMICONDUCTOR ETCH RESIDUE REMOVER AND CLEANSING COMPOSITIONS - An aqueous and semi-aqueous formulation useful for removing post etch and ash residue from Cu low K dielectric semiconductor devices. The composition comprises a polycarboxylic acid buffering system, a fluoride system, water, a water miscible organic solvent for the said aqueous compositions and optionally a chelating agent, a metal corrosion inhibitor and a surfactant. | 2008-09-25 |
20080234163 | SOLVENT FOR TREATING POLYSILAZANE AND METHOD OF TREATING POLYSILAZANE WITH THE SOLVENT - Polysilazane is treated with a single or mixed solvent comprising one or more members selected from the group consisting of xylene, anisole, decalin, cyclohexane, cyclohexene, methylcyclohexane, ethylcyclohexane, limonene, hexane, octane, nonane, decane, a C8-C11 alkane mixture, a C8-C11 aromatic hydrocarbon mixture, an aliphatic/alicyclic hydrocarbon mixture containing 5 to 25% by weight of C8 or more aromatic hydrocarbons, and dibutyl ether, wherein the number of 0.5 micron or more fine particles contained in 1 ml of the solvent is 50 or less. As the treatment of polysilazane, there are illustrated, for example, edge-rinsing and back rinsing of a polysilazane film formed by spin coating polysilazane on a semiconductor substrate. The water content of the solvent is preferably 100 ppm or less. | 2008-09-25 |
20080234164 | Alkaline Cleaner For Cleaning Aluminum Surfaces - Composition for cleaning surfaces which are susceptible to corrosion in alkaline liquids, comprising at least one alkalinity source, at least one inorganic salt containing at least one cation selected from the elements of the second or third main group of the periodic table of the elements, and whereby the composition is free of any triazole and/or any alkali metal borate, aqueous concentrate comprising the composition, use solutions comprising the composition or the aqueous concentrate and method of cleaning surfaces which are susceptible to corrosion in alkaline liquids using the above aqueous concentrate or any of the above use solutions. | 2008-09-25 |
20080234165 | Liquid laundry detergent compositions comprising performance boosters - Liquid laundry detergent compositions comprising anionic surfactant, fabric care agent, cationic deposition aid and performance booster are disclosed. The performance booster is chosen such that it will not react with the cationic deposition aid or fabric care agent to form a coacervate and/or to precipitate from solution. Such performance boosters may compensate for reduced cleaning efficacy of anionic surfactants and/or fabric care agents which interact with cationic deposition aids. | 2008-09-25 |
20080234166 | Bleaching composition using multiple oxidizers - Composition and method for bleaching are presented. The composition includes a reactor and an oxidizing agent. The reactor includes a core that contains an oxidizer reactant and generates dioxirane, percarboxylic acid, chlorine dioxide, hydroxyl radicals, and/or N-halo-amine when contacted by a main solvent. A reactor wall surrounds the core and controls diffusion of the main solvent to the core through the pores. The reactor wall has a substantially lower solubility in the main solvent than the oxidizer reactant and the generated product such that the reactor wall remains substantially intact until generation of the product is substantially complete. The oxidizing agent is in contact with the main solvent. The oxidizing agent, which may be a hypohalite donor, chlorine dioxide donor, halo-amine donor, percarboxylic acid donor, hydroxyl radical donor, persulfate(s), or a hydrogen peroxide donor, has an order of selectivity that is different from the product generated in the reactor. | 2008-09-25 |
20080234167 | Colour Protection Washing Product - Washing products which comprise a dye transfer inhibitor selected from the group consisting of triazine derivatives of the general formulae I, II, III and combinations thereof: | 2008-09-25 |
20080234168 | Laundry detergent composition with a reactive dye - Laundry detergent compositions comprising 0.00001% to 0.01% by weight of reactive dyes are disclosed. The laundry detergent compositions provide the benefit of imparting a favorable shade to fabrics without undesirable buildup of dyes on the fabrics. | 2008-09-25 |
20080234169 | Detergent composition - Liquid detergent composition comprising greater than 5% anionic surfactant, less than 15% nonionic surfactant, a light-sensitive ingredient and an inorganic pearlescent agent. | 2008-09-25 |
20080234170 | ACIDIC CLEANING COMPOSITIONS - A composition comprising a mixing product of:
| 2008-09-25 |
20080234171 | Dilution Process for Imidopercarboxylic Acids - Process for obtaining dilute aqueous solutions containing an amount of <7% by weight, expressed as a percentage by weight of imidoalkanepercarboxylic acids, starting with concentrated aqueous compositions of the said peracids in the β form, the said concentrated compositions being obtained from the imidoalkanepercarboxylic acids in the α-crystal form, the said process comprising the following steps: I) dilution of the concentrated aqueous composition of imidoalkanepercarboxylic acids (C) with an aqueous solution (D) having a pH of between 2 and 5, in a (C):(D) proportion, expressed in parts by weight, of between 0.1:10 and 10:0.2, working at temperatures of between 4° C. and 30° C.; II) application to the dilute aqueous composition obtained in I) of a shear force of at least 5000 s | 2008-09-25 |
20080234172 | Substrate Care Product - A substrate care product, such as a fabric conditioner, that provides to the substrate a primary benefit (such as fabric conditioning) and at least one secondary benefit thereto (such as fragrance), the secondary benefit being provided by at least one encapsulated volatile substance that is encapsulated in a capsule having a hydrogel shell and an oily core, the volatile substance having been loaded to blank capsules in the presence of water. The product is storage-stable, and the secondary benefit especially long-lasting. | 2008-09-25 |
20080234173 | PRESERVATIVE COMPOSITIONS - The present Invention relates to a preservative composition comprising: | 2008-09-25 |
20080234174 | FURANOID AND PYRANOID C14-C18- OXABICYCLOALKANONES AS ODORIFEROUS AND/OR AROMA SUBSTANCES - The present invention relates to compounds of the formula (I) and the formula (Ia) | 2008-09-25 |
20080234175 | Process for Designing Inhibitors of Influenza Virus Structural Protein 1 - Disclosed are methods and compositions useful in identifying inhibitors of influenza virus, such as influenza A and B virus. Also disclosed are methods for preparing compositions for administration to animals, including humans infected with or to protect against influenza virus. | 2008-09-25 |
20080234176 | MODIFIED PEPTIDES AND THEIR USES - A modified pro-α chain comprising a triple helix forming domain linked to at least an N-terminal domain, the N-terminal domain containing a polypeptide from at least part of a laminin glycoprotein or secretory leukocyte protease inhibitor. The pro-α chain may form part of a procollagen molecule that has the N-terminal domain retained. The procollagen molecule may be incorporated into collagen polymers, matrices and gels and be used for such applications as wound healing. | 2008-09-25 |
20080234177 | Targeting-enhanced activation of galectins - Lectin-binding proteins and their therapeutic use. In particular, described are the targeting and targeting-enhanced multimerization and activation of galectins. Provided is a galectin-conjugate including at least one galectin molecule conjugated to a non-galectin cell targeting means. Exemplary targeting means include targeting means able to bind EGP2, a pancarcinoma-associated cell surface target antigen, CD antigen, such as CD7 or CD38, or a TNF family member, such as TRAIL-R. The targeting means may comprise an antibody or a functional fragment thereof, such as a single chain variable antibody fragment (scFv). Also provided is the use of a galectin-conjugate for treating a disease, like cancer or an immune disorder, such as auto-immune disease, allergic disorder, auto-immune encephalomyelitis, arthritis, colitis, hepatitis, asthma, multiple sclerosis, transplant rejection, Graft-versus-host disease (GVHD) and/or inflammatory bowel disease. | 2008-09-25 |
20080234178 | COMPOSITIONS AND METHODS FOR TREATING IMMUNE SYSTEM MEDIATED DISEASES - The present invention is directed to compositions and methods for treating immune system mediated disease. In particular, certain embodiments of the present invention use BH3 mimetic therapy as an efficacious treatment of the effector phase of RA wherein the compositions and methods of the present invention markedly reduce the level of the Bcl-2 antagonist protein Bim present in RA synovial tissue as compared to control patients. Therefore, the present invention involves restoring the function of Bim in order to ameliorate inflammatory arthritis. In connection therewith, systemic delivery of a peptide to the BH3 domain of Bim effectively inhibits the development of K/B×N serum transfer-induced arthritis which closely resembles the effector phase of RA | 2008-09-25 |