39th week of 2009 patent applcation highlights part 39 |
Patent application number | Title | Published |
20090239224 | Methods for identifying bioagents - The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases. | 2009-09-24 |
20090239225 | PREDICTION AND DIAGNOSIS OF CANINE DEGENERATIVE MYELOPATHY - The present invention provides for methods of identifying a dog carrying a major genetic risk factor in the SOD1 gene for degenerative myelopathy, a potential model for human amyeotrophic lateral sclerosis. Also provided a methods of early diagnosis, treatment and breeding based on the presence or absence of the marker. | 2009-09-24 |
20090239226 | MARKERS FOR BREAST CANCER - Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described. | 2009-09-24 |
20090239227 | Method of diagnosing risk of myocardial infarction - It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene polymorphisms proved as relating to myocardial infarction; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of myocardial infarction from the genotype thus obtained. | 2009-09-24 |
20090239228 | CHIMERIC PROMOTER MOLECULES FOR GENE EXPRESSION IN PROKARYOTES - The present invention provides regulatory polynucleotide molecules isolated from a 16S rDNA for enhanced expression of heterologous genes. The invention further discloses compositions, polynucleotide constructs, transformed host cells containing the regulatory polynucleotide sequences, and methods for preparing and using the same. | 2009-09-24 |
20090239229 | DNA Repair Proteins Associated With Triple Negative Breast Cancers and Methods of Use Thereof - The present invention provides methods of detecting triple negative breast cancer recurrence using biomarkers. | 2009-09-24 |
20090239230 | Lung Cancer Diagnosis Based on Expression Levels of GIMAP Genes - Diagnosis of lung cancer based on the expression level(s) of one or more GTPase of Immunity-Associated Proteins (GIMAP) and method for identifying anti-lung cancer drug candidates based on their up-regulation of GIMAP activity. | 2009-09-24 |
20090239231 | RNA From Cytology Samples To Diagnose Disease - The invention relates to methods and kits for detecting the likelihood that a subject has cancer, e.g., squamous cell carcinoma, by assaying the expression levels of tumor associated genes. More specifically, the expression levels of nucleic acids or proteins can be assayed in the tumor associated genes, e.g., beta-2 microgobulin (B2M) and cytochrome p450 1B1 (CYP1B1). The expression levels compared to standards can be indicative of the likelihood a subject has squamous cell carcinoma. For example, over-expression of B2M and under-expression of CYP1B1 can be indicative of the likelihood a subject has squamous cell carcinoma. Also, over-expression of B2M and over-expression of CYP1B1 can be indicative of the likelihood a subject has a precancerous squamous cell disorder. The expression levels of B2M and CYP1B1 can also be repeatedly assayed to monitor the progression of a squamous cell neoplasia. | 2009-09-24 |
20090239232 | METHODS OF RNA AMPLIFICATION IN THE PRESENCE OF DNA - The invention provides methods for amplification of RNA. The methods are particularly suitable for specifically amplifying RNA in the presence of DNA. The methods involve producing a marked first primer extension product from a target RNA in the presence of a DNA-dependent DNA polymerase inhibitor, which prevents replication of DNA by the reverse transcriptase enzyme. The marked nucleic acid products are subsequently selectively amplified in the presence on non-marked nucleic acids. The methods are useful for production and analysis of polynucleotide sequences complementary to an RNA sequence. The methods are useful for preparation of nucleic acid libraries and substrates for analysis of gene expression of cells in biological samples. The invention also provides compositions and kits for practicing the amplification methods, as well as methods which use the amplification products. | 2009-09-24 |
20090239233 | SINGLE-TUBE, READY-TO-USE ASSAY KITS, AND METHODS USING SAME - An assay kit is provided that includes assay reagents stored in a single-tube container, and a data storage medium containing information about the contents of the container. Methods are provided for using the data provided with the kit to direct instruments and/or processes, for example, to control an instrument to perform amplification and/or sequencing reactions. | 2009-09-24 |
20090239234 | IDENTIFICATION AND/OR QUANTIFICATION METHOD OF NUCLEOTIDE SEQUENCE(S) ELEMENTS SPECIFIC OF GENETICALLY MODIFIED PLANTS ON ARRAYS - A method for identifying a genetically modified plant by identification and/or quantification of different, multiple nucleotide sequence elements corresponding to at least a portion of an exogenous nucleotide sequence integrated into the genome of the genetically modified plant. The method involves amplifying a nucleic acid sequence element into target nucleic acid sequences, contacting the target nucleic acid sequences with single stranded capture nucleotide sequences, detecting binding of the target nucleotide sequences, constructing a genetic map, and identifying the genetically modified plant. | 2009-09-24 |
20090239235 | Facs- and Reporter Protein-Based System for High Throughput Development of Therapeutic Proteins - Methods are disclosed to identify, select and produce a clonal population of recombinant eukaryotic host cells that stably and highly express a polypeptide of interest. Also disclosed herein are products produced by the disclosed methods and assemblies of components useful to conduct the methods. | 2009-09-24 |
20090239236 | GENE DETECTION ASSAY FOR IMPROVING THE LIKELIHOOD OF AN EFFECTIVE RESPONSE TO AN EGFR ANTAGONIST CANCER THERAPY - The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing EGFR, as determined by a gene amplification assay, with an EGFR antagonist. Such method comprises administering a cancer-treating dose of the EGFR antagonist, preferably in addition to chemotherapeutic agents, to a subject in whose tumor cells erbB1 gene has been found to be amplified e.g., by fluorescent in situ hybridization. EGFR antagonists described include an anti-EGFR antibody. | 2009-09-24 |
20090239237 | METHOD FOR THE IDENTIFICATION OF A RISK FOR A THROMBOGENIC DISORDER BY DETERMINING THE TAFl-lle347 POLYMORPHISM - The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism. | 2009-09-24 |
20090239238 | METHODS FOR MEASURING PRO-INFLAMMATORY SUBSTANCE LEVELS IN DIALYSIS SOLUTIONS AND DIALYSIS COMPONENTS - Methods of measuring levels of pro-inflammatory substances in dialysis solutions or specific dialysis components used to manufacture dialysis solutions are provided. In a general embodiment, the method comprises determining an IL-6 response versus a pro-inflammatory substance concentration of a reference standard containing a pro-inflammatory substance and establishing a dose-response curve of the IL-6 responses as a function of different pro-inflammatory substance concentrations of the reference standard. An IL-6 response of a test sample of a dialysis solution is determined. The corresponding pro-inflammatory substance concentration of the dialysis solution is then calculated using the dose-response curve. The IL-6 response of the reference standards and the dialysis solution can be determined using a high sensitivity PBMC IL-6 assay. | 2009-09-24 |
20090239239 | EUKARYOTIC AMADORIASE HAVING EXCELLENT THERMAL STABILITY, GENE AND RECOMBINANT DNA FOR THE EUKARYOTIC AMADORIASE, AND PROCESS FOR PRODUCTION OF EUKARYOTIC AMADORIASE HAVING EXCELLENT THERMAL STABILITY - Disclosed are: a eukaryotic amadoriase which is prepared by introducing a mutation into DNA encoding a eukaryotic amadoriase derived from a microorganism belonging to the genus | 2009-09-24 |
20090239240 | Mutant Forms of Fas Ligand and Uses Thereof - The invention provides for DNA encoding Fas ligand muteins and chimeras and the proteins encoded thereby. The invention further includes the use of DNA and vectors to produce transformed cells expressing the mutant or chimeric Fas ligand. When the Fas ligand of the invention is a non cleavable form, the cells expressing the Fas ligand are useful in vitro for identifying Fas expressing cells or in vivo for reducing populations of Fas expressing cells. Thus, in other embodiments, the present invention is also directed to a method for treating a patient, for example a mammal, for autoimmune disease or transplant rejection by administering a Fas ligand therapeutic agent. The therapeutic agent is a polypeptide, a polynucleotide encoding the polypeptide or a small molecule. The polypeptides include full-length Fas ligand polypeptide, or a biologically active variant, derivative, portion, fusion or peptide thereof. | 2009-09-24 |
20090239241 | METHODS AND COMPOSITIONS FOR DIAGNOSIS, STRATIFICATION, AND MONITORING OF ALZHEIMER'S DISEASE AND OTHER NEUROLOGICAL DISORDERS IN BODY FLUIDS - The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels. | 2009-09-24 |
20090239242 | Method for the early identification and prediction of kidney injury - A method for the early identification and prediction of elevated blood creatinine levels resulting from a reduction in kidney function in a subject, comprises contacting a urine sample from the subject with a capture molecule for a biomarker specific for the distal region of the renal tubule and which biomarker is released from said region when there is damage to said region indicative and predictive of elevated blood creatinine levels resulting from a reduction in kidney function. The method can be used to detect Acute Kidney Injury (AKI) caused by many conditions or diseases or through the administration of drugs. The method can indicate and/or predict a reduction in kidney function significantly earlier than the current standard creatinine test. Methods for predicting a need for renal replacement therapy (RRT) are also disclosed. | 2009-09-24 |
20090239243 | Method of identifying compounds useful to treat neuronal degenerative diseases - Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided. | 2009-09-24 |
20090239244 | MODULATORS OF PROTEIN PHOSPHATASE 2A AND PP2A METHYL ESTERASE - The disclosure relates to modulation of protein phosphorylation, including information derived from the structures and activities of the proteins designated protein phosphatase 2A (PP2A) and PP2A methyl esterase. The disclosure contained herein provides compounds and methods for identification of compounds that antagonize the function of PME, and thus reduce levels of PP2A demethylation activity. Over-expression or gain-of-function of PME contributes to a range of diseases such as cancer, thus inhibition of PME by antagonists may provide a strategy for therapeutic intervention. | 2009-09-24 |
20090239245 | METHOD FOR DIAGNOSIS AND PROGNOSIS OF EPITHELIAL CANCERS - The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy. | 2009-09-24 |
20090239246 | Biomarkers - The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection. | 2009-09-24 |
20090239247 | MN and Hypoxia - The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect, the invention provides diagnostic/prognostic tools for determining the presence of hypoxia in a tissue in a vertebrate, preferably a human, and for measuring the relative degree of hypoxia in said vertebrate. In another aspect, the invention provides methods using tumor biopsies to predict the radioresistance of a preneoplastic/neoplastic tissue in a vertebrate subject, preferably a human patient, for diseases in which MN/CA IX levels can be used to indicate radiobiologically relevant tumor hypoxia. Such predictive methods can be used as an aid in patient therapy selection. | 2009-09-24 |
20090239248 | Rapid and sensitive detection of bacteria in blood products, urine, and other fluids - The invention provides methods of detecting bacteria in fluids, including blood, platelets and other blood products for transfusion, and urine. The methods are based on lysing the bacteria to release ATP and detecting the ATP. Eukaryotic cell contamination is a problem to be overcome, because eukaryotic cell contain large amounts of ATP. Thus, some of the methods involve separating intact eukaryotic cells (e.g., platelets) from intact bacterial cells before lysing the bacterial cells to release ATP, contacting the ATP with an ATP-consuming enzyme that catalyzes a reaction, and monitoring the enzyme-catalyzed reaction. Typically, the enzyme is luciferin, and the reaction is monitored by detecting light produced by the luciferin. Other methods of the invention involve contacting a fluid sample with a support surface that binds bacterial cells, lysing the bacterial cells to release ATP, contacting the ATP with an ATP-consuming enzyme, and monitoring the enzyme-catalyzed reaction. Apparatuses for carrying out the methods are also disclosed. | 2009-09-24 |
20090239249 | NOVEL THERMOSTABLE GLUCONATE DEHYDRATASE AND USE THEREOF - The present invention relates to a novel thermostable gluconate dehydratase from the thermoacidophilic archaeon | 2009-09-24 |
20090239250 | METHOD FOR THE ANALYSIS OF CELLS - The present invention provides an improved method of analysing and obtaining reliable data about the plasma membrane of single cells, using a microfluidic cell analyser. The microfluidic cell analyser of the invention comprises a single cell trap, a manipulator arranged to manipulate the outer surface of a cell in the trap, a detection zone in communication with the single cell trap and a detector. | 2009-09-24 |
20090239251 | Method for Detecting Nanoparticles and the Use Thereof - The invention relates to a method for detecting and/or qualifying nanoparticles whose mean size is less than 60 nm, which exhibit a plasmon resonance and are located on the top surface of a flat solid support. A device for carrying out the inventive method and the use thereof are also disclosed. | 2009-09-24 |
20090239252 | RAPID DETECTION OF VOLATILE ORGANIC COMPOUNDS FOR IDENTIFICATION OF BACTERIA IN A SAMPLE - In various embodiments, the invention relates to a method for identifying the presence of particular bacteria in a sample. The method includes collecting a sample that includes or has been exposed to the particular bacteria and detecting, in the sample, at least one volatile organic compound indicative of the presence of the bacteria. | 2009-09-24 |
20090239253 | METHODS OF USING QUANTITATIVE LIPID METABOLOME DATA - Described herein in various embodiments are methods for using quantitative and/or comparative lipid metabolite data, particularly for identifying and interpreting individual metabolomic profiles as indicative of metabolic status. The provided methods, for instance, allow analysis of the likelihood or progression of weight gain or weight loss, growth or wasting, obesity, diabetes, and aging in an individual based on measurements of the measurement of the quantity of one or more lipid biomarkers, profiles of such markers, or ratios of such markers. | 2009-09-24 |
20090239254 | Functional pigmented skin equivalent - An in vitro skin equivalent includes at least one epidermis equivalent and at least one dermis equivalent, and further includes melanocytes constitutively producing melanin and fibroblasts. | 2009-09-24 |
20090239255 | Odontogenic ameloblast-associated protein as a tumor biomarker - Odontogenic ameloblast-associated (ODAM) protein may be used as an effective biomarker in humans for various cancers, especially those of epithelial origin, such as breast, lung, and stomach. The ODAM protein may be detected in cancerous cells. Additionally, the blood of patients with such cancers contains high titers of anti-ODAM antibodies. | 2009-09-24 |
20090239256 | Detection of Micro-Organisms - The present invention relates to a method of detecting the presence of a viable micro-organism of interest in a sample containing a contaminating micro-organism. | 2009-09-24 |
20090239257 | METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING - A method for analyzing a blood sample is provided that includes the steps of: a) providing a blood sample having one or more first constituents and one or more second constituents, which second constituents are different from the first constituents; b) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; c) admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce upon exposure to predetermined first wavelengths of light, and which colorant is operative to absorb light at one or more predetermined second wavelengths of light; d) illuminating at least a portion of the sample containing the first constituents and the second constituents at the first wavelengths and at the second wavelengths; e) imaging the at least a portion of the sample, including producing image signals indicative of fluorescent emissions from the first constituents and the second constituents and the optical density of the first constituents and the second constituents; f) determining a fluorescence value for each the first constituents and second constituents using the image signals; g) determining an optical density value for each of the first constituents and second constituents, which optical density is a function of the colorant absorbed by the constituents, using the image signals; and h) identifying the first constituents and the second constituents using the determined fluorescence and optical density values. | 2009-09-24 |
20090239258 | Anti-IL-6 Antibody Nucleic Acid Molecules and Methods - Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. | 2009-09-24 |
20090239259 | MAMMALIAN EXPRESSION VECTORS AND USES THEREOF - The present invention features nucleic acids for recombinant protein expression in mammalian cell culture. The episomal vectors of the invention promote high protein production in mammalian cells expressing the SV40 T Ag or Epstein-Barr virus nuclear antigen (e.g., COS7 or HEK293-6E cells). The methods and systems are useful, for example, in pharmaceutical drug development and cloning, especially for the production of antibodies. | 2009-09-24 |
20090239260 | Fungal Transcriptional Activator Useful In Methods for Producing Polypeptides - The present disclosure relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The disclosure also relates to nucleic acid constructs, vectors and host cells including the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in which the production or function of the transcriptional activator has been altered, as well as to methods for producing the polypeptides. | 2009-09-24 |
20090239261 | ASSEMBLY OF WILD-TYPE AND CHIMERIC INFLUENZA VIRUS-LIKE PARTICLES (VLPs) - Influenza virus-like particles (VLPs) comprising the structural proteins HA, NA, M1 and M2 are described. VLPs are also generated containing M1 alone, as are VLPs with M1 and any one or two of HA, NA and M2. VLPs with HA from one influenza subtype and NA from a different influenza subtype are also described, as are VLPs in which a portion or all of HA or NA is replaced by a heterologous moiety not produced by influenza virus, so as to comprise chimeric VLPs. | 2009-09-24 |
20090239262 | Affinity Polypeptide for Purification of Recombinant Proteins - The present disclosure provides an affinity polypeptide for the purification of a recombinant biologically active protein or polypeptide. Further, the present disclosure provides a fusion recombinant protein or polypeptide wherein the fusion recombinant protein comprises of at least two components, a biologically active polypeptide or protein or protein of interest and the affinity polypeptide. The biologically active polypeptide may be linked directly or indirectly to the affinity polypeptide by covalent binding. The present disclosure provides a recombinant expression vector for the producing said fusion recombinant protein in host cells. Further, the present disclosure provides an improved method of purification of recombinant protein from the host cells. Further, the disclosure provides a method of purification of the recombinant biologically active polypeptide or protein by immobilized metal ion chelating chromatography. | 2009-09-24 |
20090239263 | Expression Control Using Antibody Expression Optimisation Sequences - The present invention provides a dicistronic message for producing an antibody molecule, in which the upstream cistron contains DNA coding for the light chain of the antibody and the downstream cistron contains DNA coding for the corresponding heavy chain, characterised in that the dicistronic message comprises a sequence selected from AEOS1 (SEQ ID NO:1), AEOS2 (SEQ ID NO:2), AEOS3 (SEQ ID NO:3), AEOS4 (SEQ ID NO: 4), AEOS5 (SEQ ID NO:5), AEOS6 (SEQ ID NO:6), AEOS7 (SEQ ID NO:7), AEOS8 (SEQ ID NO:8), AEOS9 (SEQ ID NO:9), AEOS1O (SEQ ID NO:10) and AEOS1 1 (SEQ ID NO:11). | 2009-09-24 |
20090239264 | Immunization with bacterial ghost-based vaccines - Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material. | 2009-09-24 |
20090239265 | VIRUS LIKE PARTICLES - An isolated polynucleotides comprising a HBsAg-S coding sequence that is adapted to receive an insert coding sequence, within a part of the HBsAg-S coding sequence that encodes an exposed site within the external loop of HBsAgS, and still encode a HBsAg-S that is able to assemble into a VLP. Proteins encoded by the polynucleotides, recombinant VLP's and various uses thereof are also described. | 2009-09-24 |
20090239266 | Method for Producing a Non-Aromatic L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family Having Expression of the csrA Gene Attenuated - The present invention provides a method for producing a non-aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus | 2009-09-24 |
20090239267 | Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family With Attenuated Expression of the cpxR Gene - The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus | 2009-09-24 |
20090239268 | METHOD FOR PRODUCING AN L-AMINO ACID - The present invention provides a method for producing an L-amino acid by fermentation by culturing a microorganism having an L-amino acid-producing ability in a liquid medium to precipitate the L-amino acid, wherein a polymer such as a water-soluble cellulose derivative, a water-soluble polyvinyl compound, a polar organic solvent-soluble polyvinyl compound, a water-soluble starch derivative, an alginic acid salt, and a polyacrylic acid salt is added to the medium. | 2009-09-24 |
20090239269 | METHOD FOR PRODUCTION OF L-AMINO ACID - A bacterium which belongs to the Enterobacteriaceae family and has an ability to produce an L-amino acid such as L-lysine, L-threonine and L-tryptophan and is modified to enhance glutamic acid decarboxylase activity is cultured in a medium to produce and accumulate the L-amino acid in the medium or cells of the bacterium. Then, the L-amino acid is collected from the medium or the cells. | 2009-09-24 |
20090239270 | Compositions And Methods For Producing Fermentation Products And Residuals - The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism. | 2009-09-24 |
20090239271 | FERMENTATION BROTH EXTRACTION OF K-252A - Methods for separating K-252a from the cell mass of its parent fermentation broth are disclosed. | 2009-09-24 |
20090239272 | Production of flavonoids by recombinant microorganisms - Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flavonoids. The method comprises the steps of introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes. When specific substrate(s) is/are provided to the transformed cell, the enzymes act on the substrate(s) to produce the desired flavonoids. | 2009-09-24 |
20090239273 | NOVEL HIGH-ACTIVITY MODIFIED S-HYDROXYNITRILE LYASE - This invention relates to a novel high-activity modified S-hydroxynitrile lyase (SHNL). More particularly, this invention relates to novel high-activity modified SHNL that is obtained by substituting amino acids at given sites (14, 44, 66, 94, 103, 118, 122, 125, 127, 129, 147, 148, 152, 212, and 216) or inserting amino acid at a given site (between amino acids 128 and 129) of the amino acid sequence (SEQ ID NO: 2) of wild-type SHNL. | 2009-09-24 |
20090239274 | Yeast and Method of Producing L-Lactic Acid - Yeast includes an introduced gene coding a | 2009-09-24 |
20090239275 | FERMENTIVE PRODUCTION OF FOUR CARBON ALCOHOLS - Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein. | 2009-09-24 |
20090239276 | GENETICALLY MODIFIED YEAST STRAIN - A polyploid transformed yeast cell comprising a deleted or disrupted GDH1 gene encoding an NADPH-dependent glutamate dehydrogenase, said polyploid yeast cell showing increased production of ethanol and reduced production of glycerol when compared with a control polyploid yeast cell. | 2009-09-24 |
20090239277 | Thermophillic Organisms For Conversion Of Lignocellulosic Biomass To Ethanol - Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of | 2009-09-24 |
20090239278 | METHOD FOR PRODUCING BIOETHANOL FROM A LIGNOCELLULOSICBIOMASS AND RECYCLED PAPER SLUDGE - A method producing ethanol by combining an plant fiber material containing calcium carbonate with at least one lignocellulosic agricultural residue into a mixture. The plant fiber material can be a paper sludge. The mixture is then hydrolyzed and the resultant hydrolysate is then fermented into ethanol. | 2009-09-24 |
20090239279 | Integrated Biofuel Production System - According to an embodiment, a biomass conversion subsystem produces methane and/or alcohol and residual biomass. A pyrolysis or a gasification subsystem is used to produce thermal energy and/or process gasses. The thermal energy may be stored thermal energy in the form of a pyrolysis oil. A fuel conversion subsystem produces liquid hydrocarbon fuels from the methane and/or alcohol using thermal energy and/or process gasses produced by the gasification or pyrolysis subsystem. Because the biomass production system integrates the residual products from biomass conversion and the residual thermal energy from pyrolysis or gasification, the overall efficiency of the integrated biomass production system is greatly enhanced. | 2009-09-24 |
20090239280 | METHOD FOR PRODUCING METAL NANOPARTICLES - This invention provides a method for producing a composition comprising colloidal nanoparticles of metals including silver, gold, zinc, mercury, copper, palladium, platinum, or bismuth, by contacting a metal or metal compound with bacteria. An embodiment of the method comprises a step of incubating probiotic bacteria with an aqueous solution comprising at least 4 mM of a silver or gold salt. A resulting nanosilver-containing composition is useful as a highly efficient antimicrobial agent, for instance when impregnated onto a carrier, or an algicide agent or a herbicide agent. | 2009-09-24 |
20090239281 | Moving A Small Object in A Direction - For directional motion of a small object, a combination of at least two different properties is imparted to the object. At least one of the properties being responsive to an external influence to produce a force or torque acting on the object. At least another of the properties is responsive to the force or torque to cause a directional motion of the object. | 2009-09-24 |
20090239282 | Method of storing and/or transporting in vitro cell cultures - The invention relates to a method of storing and/or transporting in vitro two-dimensional cell cultures. The inventive method comprises the following steps consisting in: a) coating a cell culture that is immobilised on an asymmetric support with a gelatine solution in culture medium at a concentration of between 1 and 5%; b) solidifying the gelatine added to the support at a temperature of between 15 and 25° C.; and c) storing and/or transporting the cell culture at a temperature of between 15 and 25° C. for a period of up to 96 hours. The invention also relates to a kit which is used to store and/or transport the in vitro two-dimensional cell cultures according to the inventive method, said kit comprising: i) an asymmetric support, and (ii) a gelatine solution in culture medium at a concentration of between 1 and 5%. | 2009-09-24 |
20090239283 | PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION (PAP) - A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3′-deoxynucleotide at its 3′ terminus. PAP can be applied for exponential amplification or for linear amplification. PAP can be applied to amplification of a rare allele in admixture with one or more wild-type alleles by using an activatable oligonucleotide P* that is an exact match at its 3′ end for the rare allele but has a mismatch at or near its 3′ terminus for the wild-type allele. PAP is inhibited by a mismatch in the 3′ specific sequence as far as 16 nucleotides away from the 3′ terminus. PAP can greatly increase the specificity of detection of an extremely rare mutant allele in the presence of the wild-type allele. Specificity results from both pyrophosphorolysis and polymerization since significant nonspecific amplification requires the combination of mismatch pyrophosphorolysis and misincorporation by the DNA polymerase, an extremely rare event. Using genetically engineered DNA polymerases greatly improves the efficiency of PAP. | 2009-09-24 |
20090239284 | Alkaline Bacillus Amylase - This invention relates to an amylase derived from | 2009-09-24 |
20090239285 | TANDEM REAPEAT DNA CONSTRUCTS PRODUCING PROTEINS THAT ATTACK PLANT PATHOGENIC VIRUSES, FUNGI, AND BACTERIA BY DISRUPTING TRANSCRIPTION FACTORS ESSENTIAL FOR REPLICATION THEREOF IN PLANTS - Methods and compositions reduce growth of Geminiviruses employing a compound with the following structure: | 2009-09-24 |
20090239286 | PRODUCTION OF POXVIRUSES WITH ADHERENT OR NON ADHERENT AVIAN CELL LINES - The present invention relates to a method for replicating poxviruses such as vaccinia virus comprising the steps of inoculating avian embryonic stem cells with viral particles and culturing said cells in a basal medium until cells lysis occurs and newly produced viral particles are released in said medium. | 2009-09-24 |
20090239287 | Production of vaccines - Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removing the virus-containing medium. The viruses can be harvested and be used for the production of vaccines. Advantages are that human cells of the present invention can be cultured under defined serum free conditions, and the cells show improved capability for propagating virus. In particular, methods are provided for producing, in cultured human cells, influenza virus and vaccines derived thereof. This method eliminates the necessity to use whole chicken embryos for the production of influenza vaccines. The method provides also for the continuous or batchwise removal of culture media. As such, the invention allows the large-scale, continuous production of viruses to a high titer. | 2009-09-24 |
20090239288 | INTEGRATED MEMBRANE SEPARATION - BIOREACTOR FOR SELECTIVE REMOVAL OF ORGANIC PRODUCTS AND BY-PRODUCTS - A system for selective removal of metabolites from an aqueous broth including a bioreactor vessel containing at least one live culture producing at least one metabolite disposed within an aqueous broth, and a membrane module having a mixed matrix membrane suitable for selective removal of the at least one metabolite from the aqueous broth. The membrane is made of mixtures of hydrophobic zeolite and carbon on a porous substrate. In accordance with one particularly preferred embodiment of this invention, the membrane module is integral with the bioreactor vessel. | 2009-09-24 |
20090239289 | Drain Foam Composition and Method of Using the Same - A foamable aqueous cleaning composition for treating surfaces to dissolve grease and organic waste materials thereon. The foamable aqueous cleaning composition comprises a) about 40 to about 60 percent by weight water; b) about 40 to about 60 percent by weight of a bioremediation agent capable of breaking down organic contaminating material and capable of producing a desired number of colony forming units of microbes; c) optionally, an insect growth regulator; and d) about 7 to about 15 percent by weight of a compatible propellant. The foamable composition is aerosolized to release the foam composition and contacted with the surfaces to be treated. The foamable composition can be used to treat drains, baseboards, cracks, crevices and other similar surfaces, especially in food preparation areas. | 2009-09-24 |
20090239290 | SINGLE-TUBE, READY-TO-USE ASSAY KITS, AND METHODS USING SAME - An assay kit is provided that includes assay reagents stored in a single-tube container, and a data storage medium containing information about the contents of the container. Methods are provided for using the data provided with the kit to direct instruments and/or processes, for example, to control an instrument to perform amplification and/or sequencing reactions. | 2009-09-24 |
20090239291 | CULTURE VESSEL ALLOWING LARGE IN SITU SCALE UP - The present invention, in one aspect, provides a culture vessel which includes a body having at least a first edge at least partially perimetrically bounding the body, and at least a first seal extending from the first edge. The first seal is breachable and fluid-tight, and disposed obliquely to the first edge so as to subtend an acute angle therewith. The first seal separates the body into first and second chambers. Advantageously, with the subject invention, a culture vessel is provided which allows for volume expansion in situ. | 2009-09-24 |
20090239292 | MICROFABRICATED APPARATUS FOR CELL BASED ASSAYS - Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each micro-channel element comprising a cell growth chamber, an inlet channel and an outlet channel, a cover plate positioned over the base plate to define the chambers and connecting channels. Means are incorporated in the cell growth chambers, for cell attachment and cell growth. In particular, the invention provides a rotatable disc microfabricated for performing cell growth and cell based assays. The apparatus and method can be used for the growth of cells and the detection and measurement of variety of biochemical processes and products using non-invasive techniques, that is techniques which do not compromise the integrity or viability of cells. | 2009-09-24 |
20090239293 | Grooved High Density Plate - A microplate having a main body portion. The main body portion having a first surface and an opposing second surface, and a groove disposed about the first surface of the main body portion. The groove separates the main body portion into an inboard section and an outboard section. A plurality of wells are formed in the inboard section of the first surface and each of the plurality of wells being sized to receive an assay therein. | 2009-09-24 |
20090239294 | Coaxial Tissue Block Puncher Set - A coaxial tissue block puncher set comprises a carrier mechanism, the first, second and third operating mechanisms being respectively installed at proper positions thereon, while each of the operating mechanisms respectively has a base and a lifting unit being movingly installed on the base, wherein lifting unit of the first operating mechanism is movingly installed with a first punch needle tube, lifting unit of the second operating mechanism being movingly installed with a second punch needle tube is pierced through the first punch needle tube, and lifting unit of the third operating mechanism being movingly installed with a thimble is pierced through the second punch needle tube. Therefore, user is able to punch-extract relevant pathological paraffin and put to relevant position in the empty block thereby forming a tissue array without the need for tedious manual methods thus achieving the effectiveness of fastness, precision and easy operation, etc. | 2009-09-24 |
20090239295 | Dedifferentiated, Programmable Stem Cells of Monocytic Origin, and Their Production and Use - The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for the production of target cells and target tissue. | 2009-09-24 |
20090239296 | Compositions and Methods for Modifying Cell Surface Glycans - Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein. | 2009-09-24 |
20090239297 | AVIAN CELL LINES USEFUL FOR THE PRODUCTION OF SUBSTRATES OF INTEREST - The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells derived from such lines which are particularly useful for the production of substances of interest. | 2009-09-24 |
20090239298 | Methods of generating embryoid bodies using three dimensional scaffolds - A method of generating embryoid bodies is provided. The method comprising culturing undifferentiated embryonic stem cells on a three dimensional scaffold under conditions suitable for formation of embryoid bodies, thereby generating the embryoid bodies. | 2009-09-24 |
20090239299 | AUTOLOGOUS TISSUE HARVESTING AND IRRIGATION DEVICE - The present invention includes a harvesting and irrigation device, a method and a kit for the collection of viable fat cells and/or adipose tissue with decreased handing and improved yield and viability. | 2009-09-24 |
20090239300 | SEPARATING MATERIAL AND METHOD FOR COLLECTING CELL OR THE LIKE USING THE SAME - The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method of harvesting a cell such as monocyte and the like using the isolation material, a method of harvesting a protein and a method of preparing a dendritic cell. | 2009-09-24 |
20090239301 | USE OF VINCA ALKALOIDS AND SALTS THEREOF - An agent containing a vinca alkaloid or its pharmacologically acceptable salt as an active ingredient can induce insulin production and/or secretion of non-neoplastic cells derived from the pancreas. | 2009-09-24 |
20090239302 | Method for Constructing Functional Living Materials, Resulting Materials and Uses Thereof - The invention concerns a method for constructing a functional living biomaterial, characterized in that it consists in assembling layer by layer (3D) a matrix and 2D layers of functional living cells by controlling their interactions and 3D structuring based on the desired organization and final shape of the biomaterial, wherein each layer has its own pattern adapted to the neighbouring layers and on the functionality of whole synthetic biomaterials. The invention is useful in the field of biomedicine and nanobiotechnology. | 2009-09-24 |
20090239303 | Ultrasonic Machining Fabrication of Guided Tissue Generation Surfaces and Tissue Scaffolds - Ultrasonic machining is used to fabricate at least a portion of patterned surfaces that are used directly or indirectly for guided tissue generation. Tissues may be cultivated directly in the patterned surfaces or the patterned surfaces may be used as molds for polymer tissue scaffolds. | 2009-09-24 |
20090239304 | BIOACTIVE PEPTIDE FOR CELL ADHESION - Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a specific peptide sequence within domain IV of perlecan. The devices adhere epithelial cells, epithelial stem cells, mesenchymal stem cells, and osteoblasts. | 2009-09-24 |
20090239305 | Gene recombination exchange system for stable gene modification in human ES cells - A method of creating a human pluripotent transgenic stem cell, wherein heterologous DNA is inserted into specific “hot-spots” in the genome where stable and high gene expression may occur, is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a pluripotent stem cell line, and (b) inserting heterologous DNA at an insertion site selected from the group consisting of insertion site one and insertion site two to form a transgenic cell line. In another embodiment, the heterologous DNA is an exchange cassette and the transgenic cell line formed is a master cell line. | 2009-09-24 |
20090239306 | REFERENCE MATERIAL FOR ASSAYING D-DIMER - The present invention relates to a reference material for assaying D-dimer, comprising a fibrin degradation product, wherein no less than 70% of a total peak area has the molecular weight of no less than 500,000 in a molecular weight distribution of the fibrin degradation product, measured by gel filtration chromatography. | 2009-09-24 |
20090239307 | Filter with memory, communication and concentration sensor - The present invention describes a system and method for accurately measuring the concentration of a substance within a filter housing. A concentration sensor and a communications device are coupled so as to be able to measure and transmit the concentration of a particular substance within the filter housing while in use. This system can comprise a single component, integrating both the communication device and the concentration sensor. Alternatively, the system can comprise separate sensor and transmitter components, in communication with one another. In yet another embodiment, a storage element can be added to the system, thereby allowing the device to store a set of concentration values. The use of this device is beneficial to many applications. For example, the ability to read concentration values in situ allows integrity tests to be performed without additional equipment. | 2009-09-24 |
20090239308 | METHOD AND APPARATUS FOR DETERMINING COPY NUMBER VARIATION USING DIGITAL PCR - A method of estimating a concentration of DNA molecules in a biological sample includes storing a number of a plurality of reaction sites in a memory and distributing the biological sample among the plurality of reaction sites. The method also includes determining a number of the plurality of reaction sites characterized by a presence of one or more of the DNA molecules and computing a portion of the plurality of reaction sites characterized by the presence of the one or more of the DNA molecules. The method further includes estimating the concentration of the DNA molecules as a function of the portion of the plurality of reaction sites and computing a confidence interval for the estimated concentration of DNA molecules. | 2009-09-24 |
20090239309 | METHOD OF STABILIZING PULMONARY SURFACTANT PROTEIN - The present invention relates to a method for long-term stabilizing a pulmonary surfactant protein, to a stabilized aqueous solution containing a pulmonary surfactant protein, and to a kit for assaying a pulmonary surfactant protein which kit contains, as a component reagent, a stabilized aqueous solution containing a pulmonary surfactant protein. | 2009-09-24 |
20090239310 | KOKUMI-IMPARTING AGENT - The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi. | 2009-09-24 |
20090239311 | Method of Differentially Diagnosing Dementias - In an ex vivo method of differentially diagnosing dementias selected from a group of demetias, which includes vascular dementias and frontotemporal lobe degenerations, a concentration of at least one carboxy-terminally truncated amyloid β peptide species as a biomarker is determined in a body fluid obtained from a patient, the at least one carboxy-terminally truncated amyloid β peptide species being selected from the group of species consisting of Aβ1-38, Aβ1-37 and Aβ1-39; and the concentration of the at least one carboxy-terminally truncated amyloid β peptide species is compared to a threshold concentration value for the respective one carboxy-terminally truncated amyloid β peptide species. | 2009-09-24 |
20090239312 | Chromosome 6 and 9 Genes Involved in Premature Canities - The invention provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 9 selected from the group consisting of the FREQ, NT_030046.18, NT_030046.17, GTF3C5, CEL, CELL, FS, ABO, BARBLI, DDX31, GTF3C4 and Q96MA6 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 6 selected from the HLAG, NT_007592.445, NT_007592.446, NT_007592.506, NT_007592.507, NT_007592.508, HSPA1 B, G8, NEU1, NG22, BAT8, HLA-DMB, HLA-DMA, BRD2, HLA-DQA1, HLA-DQA2, NT_007592.588, GRM4, RNF23, FLJ22638, NT_007592.459 and NT_007592.457 genes, and diagnostic methods employing same. | 2009-09-24 |
20090239313 | Integrated Circuit Chip Design Flow Methodology Including Insertion of On-Chip or Scribe Line Wireless Process Monitoring and Feedback Circuitry - Disclosed are embodiments of a design and manufacturing system and an associated method that allow for design analysis and for insertion, during wafer manufacture, of intra-process monitoring circuitry. These embodiments use a library of pre-qualified intra-process monitoring circuits and a cross-correlation table that links different monitoring circuits with different IC chip components. Specifically, these embodiments analyze integrated circuit chip design data to identify the components designed into the chip. Then, one or more intra-process monitoring circuits are selected from the library and the design data is modified to include the selected monitoring circuit(s). | 2009-09-24 |
20090239314 | Methods of Manufacturing a Semiconductor Device - Methods of manufacturing a semiconductor device and an apparatus for the manufacturing of semiconductor devices are provided. An embodiment regards providing a process which changes the volume of at least one layer of a semiconductor substrate or of at least one layer deposited on the semiconductor substrate, and measuring a change in volume of such at least one layer using fluorescence. In another embodiment, a change in volume of such at least one layer is measured using reflection of electromagnetic waves. | 2009-09-24 |
20090239315 | METHOD AND SYSTEM FOR PROCESSING TEST WAFER IN PHOTOLITHOGRAPHY PROCESS - A method and a system for processing a test wafer in a photolithography process are provided for processing an i | 2009-09-24 |
20090239316 | METHOD AND SYSTEM TO DYNAMICALLY COMPENSATE FOR PROBE TIP MISALIGNEMENT WHEN TESTING INTEGRATED CIRCUITS - Method for dynamically compensating probe tip misalignment with a semiconductor wafer. The wafer is located on a handler and the wafer is adjusted to a first temperature. Probe tips of an inspection system are moved to a first position centered above pads of a test module on the wafer. The first position is recorded in a memory of the inspection system at the first temperature. The wafer and the probe tips are adjusted to a second temperature while the wafer remains in the inspection system. A second position of the probe tips is recorded in the memory while the probe tips and the wafer are equilibrated at the second temperature. A difference between the first and second position is calculated. Relative positions of the probe tips or the wafer is compensated based on the calculated difference, such that the probe tips are re-centered above the pads at the second temperature. | 2009-09-24 |
20090239317 | Method and jig structure for positioning bare dice - A method and jig structure for positioning bare dice is disclosed. The jig structure for positioning at least one bare dice includes a trap having at least one positioning groove wherein the depth of the positioning groove is less than the height of the bare dice. Basing on the positioning groove formed in the tray, once a bare dice is placed in the positioning groove, the partially exposed bare dice can be located directly and precisely vacuum-grabbed by a sucker, so that the number of positioning steps is reduced. | 2009-09-24 |
20090239318 | Glass-coated light-emitting element, light-emitting element-attached wiring board, method for producing light-emitting element-attached wiring board, lighting device and projector - A glass-coated light-emitting element | 2009-09-24 |
20090239319 | Package for a light emitting diode and a process for fabricating the same - A package for an LED, comprises a metal substrate, at least one LED chip, and an insulative housing, wherein the metal substrate has a first terminal and a second terminal, and the first terminal is formed with a recess. The at least one LED chip is arranged in the recess of the first terminal of the metal substrate, wherein the chip is electrically connected with the first terminal and the second terminal of the metal substrate. Since the insulative housing caps the chip and the metal substrate, and the LED package can be reduced in size. | 2009-09-24 |
20090239320 | SEMICONDUCTOR DEVICE AND PEELING OFF METHOD AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - The present invention provides a peeling off method without giving damage to the peeled off layer, and aims at being capable of peeling off not only a peeled off layer having a small area but also a peeled off layer having a large area over the entire surface at excellent yield ratio. The metal layer or nitride layer | 2009-09-24 |
20090239321 | TRANSISTOR ARRAY SUBSTRATE AND DISPLAY PANEL - A transistor array substrate includes a plurality of driving transistors which are arrayed in a matrix on a substrate. The driving transistor has a gate, a source, a drain, and a gate insulating film inserted between the gate, and the source and drain. A plurality of signal lines are patterned together with the gates of the driving transistors and arrayed to run in a predetermined direction on the substrate. A plurality of supply lines are patterned together with the sources and drains of the driving transistors and arrayed to cross the signal lines via the gate insulating film. The supply line is electrically connected to one of the source and the drain of the driving transistor. A plurality of feed interconnections are formed on the supply lines along the supply lines, respectively. | 2009-09-24 |
20090239322 | Method of fabricating liquid crystal display - A liquid crystal display device includes a driving circuit provided with a switching device on a liquid crystal display panel, the switching device including a plurality of thin film transistors connected in parallel and commonly interconnected using a gate electrode. | 2009-09-24 |
20090239323 | Microresonator Systems And Methods Of Fabricating The Same - Various embodiments of the present invention are related to microresonator systems and to methods for fabricating the microresonator systems. In one embodiment, a method of fabricating a microresonator system comprises: forming a multilayer system having a bottom layer, a top layer, and an intermediate layer having one or more quantum wells and sandwiched between the bottom layer and the top layer; embedding at least one waveguide in a substrate having a top surface, the at least one waveguide positioned adjacent to the top surface of the substrate; wafer bonding the top layer of the multilayer system to the top surface of the substrate; forming a microresonator in the multilayer system, wherein at least a portion of a peripheral annular region of the microresonator is portioned above the at least one waveguide; and forming a current isolation region in at least a portion of a central region of the microresonator. | 2009-09-24 |