38th week of 2012 patent applcation highlights part 43 |
Patent application number | Title | Published |
20120237936 | METHODS AND RELATED DEVICES FOR SINGLE MOLECULE WHOLE GENOME ANALYSIS - Provided are methods of labeling and analyzing features along at least one macro molecule such as a linear biopolymer, including methods of mapping the distribution and frequency of specific sequence motifs or the chemical or proteomic modification state of such sequence motifs along individual unfolded nucleic acid molecules. The present invention also provides methods of identifying signature patterns of sequence or epigenetic variations along such labeled macro molecules for direct massive parallel single molecule level analysis. The present invention also provides systems suitable for high throughput analysis of such labeled macro mo lecules. | 2012-09-20 |
20120237937 | METHODS TO DETECT CANCER IN ANIMALS - Some embodiments of the invention include methods for detecting the presence of cancer in animal tissue in an animal that was administered a labeled molecule. Some of the methods disclosed comprise obtaining an NMR spectrum, an MS spectrum, or both. In some instances, spectra can be taken of a cancer cell extract of the tissue and of a non-cancer cell extract of the tissue. In some embodiments, the amounts of at least one resultant labeled molecule (e.g., a molecule resulting from transformation of the administered labeled molecule) from each extract can be compared to detect the presence of cancer. | 2012-09-20 |
20120237938 | METHODS FOR IMPROVED DNA RELEASE FROM BINDING SUBSTRATES AND/OR DECREASING PCR INHIBITION IN PATHOGEN DETECTION - Disclosed herein are processes for collecting nucleic acids from particulate samples. One embodiment disclosed herein relates to the use of ultrasonic energy to simultaneously shear large nucleic acid molecules and large particulates to very small sizes prior to or during a chemical binding step to a nucleic acid binding surface. Another embodiment involves crushing the nucleic acid binding surface prior to eluting the bound nucleic acid molecules to enable better wetting of the nucleic acid binding surface and easier diffusion of bound nucleic acid molecules out of the nucleic acid binding surface. | 2012-09-20 |
20120237939 | DEVICES AND PROCESSES FOR NUCLEIC ACID EXTRACTION - Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface effective for binding a heterogeneous population of nucleic acids. The first port, second port, and binding chamber define a continuous fluid pathway that is essentially free of nucleic acid-specific binding sites. | 2012-09-20 |
20120237940 | APPARATUS AND METHOD - An apparatus for investigating a molecule comprising a channel provided in a substrate, a metallic moiety capable of plasmon resonance which is associated with the channel in a position suitable for the electromagnetic field produced by the metallic moiety to interact with a molecule passing therethrough, means to induce a molecule to pass through the channel, means to induce surface plasmon resonance in the metallic moiety; and means to detect interaction between the electromagnetic field produced by the metallic moiety and a molecule passing through the channel. Methods of investigating molecules are also provided. | 2012-09-20 |
20120237941 | METHOD FOR SCREENING ACTIVE AGENTS THAT STIMULATE THE EXPRESSION OF ARNT2 TO IMPROVE THE SKIN'S BARRIER FUNCTION - A method for screening an active agent intended for preventing or combating the cutaneous signs resulting from a non-pathological impairment of the barrier function, which includes the selection of active agents that stimulate the expression of ARNT2 in cultured human keratinocytes. | 2012-09-20 |
20120237942 | METHODS AFFECTING MARKERS IN PATIENTS HAVING VASCULAR DISEASE - Marker levels and forms can be modulated in patients having vascular disease when sufficient vascular tissue is removed. The markers can be, e.g., from tissue, blood or lymph. The markers are typically involved in molecular pathways which are in turn modulated. Atherectomy catheters are used for accomplishing sufficient removal of vascular tissue to effect the modulations. | 2012-09-20 |
20120237943 | METHOD FOR DIFFERENTIATION OF POLYNUCLEOTIDE STRANDS - Objective of the present invention is to provide a method for keeping of directional information in double-stranded DNA. We suggest to convert polynucleotide into a hybrid double-stranded DNA. One particular strand of this hybrid double-stranded DNA should be synthesised using at least one modified nucleotide. Thus, this particular strand would contain modified nucleotides along the whole length. Density of directional markers would not depend on the length of polynucleotides. Any internal fragments of the hybrid double-stranded DNA would have directional information. When it is necessary the modified strand may be easily degraded or separated from the other strand. It was found that such hybrid double-stranded DNA may be easily generated in a number of molecular biology tasks and may be used for molecular cloning, library preparation and strand separation. | 2012-09-20 |
20120237944 | DETECTION DEVICE FOR THE IN VIVO AND/OR IN VITRO ENRICHMENT OF SAMPLE MATERIAL - The present invention refers to a detection device for the in vivo and/or in vitro enrichment of sample material, the detection device comprising a functional surface equipped with detection receptors. To further improve the enrichment of sample material by using a detection device of the aforementioned type, it is provided according to the invention that the functional surface has a three-dimensional structure with mutually facing functional sections which form spaces that can be filled with a sample liquid. Furthermore, the present invention provides for a use and for a method for the use of the detection device. | 2012-09-20 |
20120237945 | CHIMERIC PCSK9 PROTEINS, CELLS COMPRISING SAME, AND ASSAYS USING SAME - A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes. | 2012-09-20 |
20120237946 | MESENCHYMAL STEM CELL AND THE METHOD OF USE THEREOF - Demyelinated axons were remyelinated in the demyelinated rat model by collecting bone marrow cells from mouse bone marrow and transplanting the mononuclear cell fraction separated from these bone marrow cells. | 2012-09-20 |
20120237947 | Glutathione S-Transferase Omega 1 Wild Type Specific Antibody - The invention relates to a novel antibody which binds to wild type (wt) Glutathione S-transferase Omega 1 (wtGSTO1) but not to mutant (mut) GSTO1 and methods and uses based on the antibody. The antibody is based on novel haptens and immunogens. | 2012-09-20 |
20120237948 | COLLAGEN NEOEPITOPE ANTIBODY - The present invention provides a novel monoclonal antibody that is specific for a C-terminal neoepitope of a collagen fragment and has substantially equal binding affinity whether proline contained in the neoepitope is in a non-hydroxylated form or in a hydroxylated form, and an immunoassay, a measurement method, a kit and the like using the antibody. The antibody allows for quantification of a collagen fragment generated by digestion of a biological sample with a collagenase present in the sample, regardless of the presence or absence of a hydroxylated form of proline in the neoepitope. | 2012-09-20 |
20120237949 | SPECIFIC DETECTION AND QUANTIFICATION OF PHOSPHATIDIC ACID USING AN ARABIDOPSIS TRIGALACTOSYLDIACYLGLYCEROL-4 (TGD4) PROTEIN - The present invention is related to the field of phospholipid detection. In particular, certain embodiments provide the detection of phosphatidic acid. For example, certain proteins are capable of binding phosphatidic acid and can be used as a diagnostic and/or research tool to identify and quantitate phosphatidic acid. Phosphatidic acid may be in or from cells and tissues isolated from plants, animals and humans. For example, a trigalactosyldiacylglycerol-2 (TGD2) protein may be fused with a fluorescent probe to monitor and measure phosphatidic acid in vitro as well as in vivo. In other embodiments, a trigalactosyldiacylglycerol-4 (TGD4) protein may be fused with a fluorescent probe to monitor and measure phosphatidic acid in vitro as well as in vivo. In additional embodiments, a fragment comprising either a truncated TGD2 or TGD4 phosphatidic acid binding region protein may be used to monitor or measure phosphatidic acid. | 2012-09-20 |
20120237950 | ANALYSIS CHIP, ANALYSIS SYSTEM, AND ANALYSIS METHOD - An analysis chip for quantitative analysis by using a competitive reaction is provided. The analysis chip for analyzing a target substance to be identified in a liquid sample includes a base, and a flow path formed on the base. The flow path includes an introduction portion, for introducing the liquid sample; a reaction portion, disposed at a downstream side of the introduction portion, for subjecting the liquid sample to a competitive reaction; a discharge portion, disposed at a downstream side of the reaction portion; and a blocking portion, disposed between the reaction portion and the discharge portion, for inhibiting the flow of the liquid sample from the reaction portion to the discharge portion. The reaction portion accommodates a carrier prefixed with a specific binding substance for specifically binding the target substance to be identified or a competitive substance of the target substance to be identified. | 2012-09-20 |
20120237952 | MYOSIN-IIA S1943 PHOSPHORYLATION AS A MARKER OF TUMOR INVASION - Methods and kits are provided for determining if cells of a tumor in an organ or a tissue in a subject are likely to invade another organ or tissue in the subject and for determining if a cancer in a subject is likely to metastasize. | 2012-09-20 |
20120237953 | Methods to Identify Modulators - Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose, and an inhibitor, are provided. | 2012-09-20 |
20120237954 | BIOMARKERS FOR PROGNOSES OF PULMONARY DISEASES - The present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic regimens. It is based, at least in part, on the discovery that a number of T-cell antigens are differentially expressed in chronic lung disease patients depending on the prognosis of the patient. Non-limiting examples of these antigens include CD28, CD4, CD25, CD45, CD27 and CCR7 and combinations thereof. Use of these biomarker antigens, optionally in conjunction with pulmonary function tests, provides an indication of which patients are likely to suffer a severely adverse outcome within the year and/or be refractory to treatment. | 2012-09-20 |
20120237955 | METHODS FOR IDENTIFYING INHIBITORS OF BOTULINUM NEUROTOXINS - A system and method for identifying a | 2012-09-20 |
20120237956 | TREPONEMA PALLIDUM TRIPLET ANTIGEN | 2012-09-20 |
20120237957 | Method For Enhancing Enzyme Assays - Additives capable of controlling the reaction rate between substrate and enzyme to form a dye in enzyme assays with absorbance, chemiluminescence, and fluorescence are effective tools for optimizing enzyme assays. A dye can be formed rapidly from the reaction between enzyme and substrate in the presence of a catalyst. Using relatively high concentration of dye formed from the rapid reaction, trace levels of analytical materials can be quantified using absorbance, chemiluminecence and fluorescence detection. A dye can be formed from a relatively slow reaction between enzyme and substrate in the presence of a surfactant such as Triton X-100 and β-cyclodextrin. Using relatively low concentration of dye from the slow reaction, a high concentration of analytical material can be quantified without any dilution using absorbance, chemiluminescence, and fluorescence. | 2012-09-20 |
20120237958 | METHODS FOR IDENTIFYING ANIMALS WITH A REDUCED ABILITY TO DIGEST LIPID AND PROTEIN - The invention provides methods for identifying animals with a reduced ability to digest fat or protein by determining various blood and physical factors for the animals and comparing the determined values to standard values that are indicative of a reduced ability to digest fat and protein. | 2012-09-20 |
20120237959 | TUMOR ENDOTHELIAL MARKER 5-ALPHA MOLECULES AND USES THEREOF - The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM5α polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, or prevention of diseases, disorders, and conditions associated with TEM5α polypeptides. | 2012-09-20 |
20120237960 | Devices and Methods for Determining the Platelet Function in a Centrifugal Analyzer - The invention lies in the field of platelet function diagnostics and relates to devices and methods for determining the platelet function in a centrifugal analyzer. | 2012-09-20 |
20120237961 | Labelling of Fusion Proteins with Synthetic Probes - The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O | 2012-09-20 |
20120237962 | MCAM AS A BIOMARKER FOR FLUID HOMEOSTASIS - The application discloses MCAM as a new biomarker for fluid homeostatic imbalance; methods for predicting, diagnosing, prognosticating and/or monitoring fluid homeostatic imbalance based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods. | 2012-09-20 |
20120237963 | APPARATUS AND METHOD FOR ASSESSING COMPOSTABILITY OR BIODEGRADABILITY - An apparatus and method for performing compostability tests that provides significantly more data and reveals trends much more quickly than previously described apparatus. In a first aspect, the invention provides an apparatus, comprising: a flowmeter for metering a flow of oxygen-containing gas to a humidifier; a bioreactor comprising a body, a gas inlet mounted on the body and connected to the humidifier, a dispersive element for distributing the flow of humidified gas throughout the body, and a gas outlet; a first moisture trap connected to the outlet a mass flow meter connected to the first moisture trap for accurately measuring the mass flow from the outlet; and a non-dispersive IR detector for measuring the carbon dioxide in the gas from the outlet. Convenient embodiments include a digitally controlled electronic manifold for sequentially directing gas flows from multiple reactors to the analyzer/detector. | 2012-09-20 |
20120237964 | LUMINOGEN COMPOUNDS AND THE USE OF THE SAME FOR BIOSENSING AND CELLULAR IMAGING - Provided herein are a luminogen compound of formula (I) including a AIE luminophore moiety conjugated with a maleimide moiety and a use of the same for detecting thiol groups in biomolecules. Also provided is a dye molecule, a biosensor or a bioprobe comprising the luminogen compound of formula (I) in use for detecting thiol groups in biomolecules. The detection method of the present subject matter not only has high thio-selectivity and sensitivity, but also is rapid, convenient and handy. | 2012-09-20 |
20120237965 | SYSTEMS AND METHODS FOR A CONTINUOUS CULTURE BIOSENSOR - A continuous culture system of genetically modified yeast or another biological organism detects contaminants in water through production of a fluorescent chemical continuously produced by the organism after it is contacted with a threshold concentration of a contaminant. Alternatively, a biological organism can detect toxins or extra nutrients by detecting a change in growth rate. Biological organisms can also be measured for mutagenic changes by comparing their genome with a control sample. A network of continuous culture systems may be used as part of a water contamination detection system for real-time water monitoring of contaminants from multiple sources simultaneously. | 2012-09-20 |
20120237966 | Light Controlled Protein Dimerization in Cells - Compositions and methods for light controlled protein-protein interactions in a living cell. Two interacting PICL (protein interaction controlled by light) polypeptides are provided. The first polypeptide comprises an LOV (Light, Oxygen or Voltage) domain, which domain is a light sensor that uses flavin mononucleotide (FMN) as a chromophore. The second polypeptide, specifically interacts with the L polypeptide upon light activation of the LOV domain. One or both of the polypeptides are fused to a cellular protein of interest. Upon exposure to light, a targeted interaction between cellular proteins occurs. The ability to regulate protein-protein interactions with subcellular resolution using light is useful for controlling biochemical processes such transcription, receptor activation, protein degradation, synapse formation, etc. in cells and animals. | 2012-09-20 |
20120237967 | Method for Microbiological Testing - Costly enrichment medium used for microbiological testing of nuts and other moisture-absorbing food products is conserved by saturating the product with water or other inexpensive liquid prior to contacting the product with enrichment medium. | 2012-09-20 |
20120237968 | Detector and Method for Detection of H. Pylori - An inexpensive, portable, hand held, point-of-care, non-invasive breath-analyzer for the detection of | 2012-09-20 |
20120237969 | Method of Preparing Cells Susceptible to Transmissible Spongiform Encephalopathy and the Creation of TSE Persistently Infected Cells - Disclosed is a method for preparation of transmissible spongiform encephalopathy (TSE) susceptible cells, and such cells may be efficiently used in diagnosis of TSE, etiology studies and development of novel therapeutics, etc. | 2012-09-20 |
20120237970 | METHOD FOR OBTAINING NATURAL EXTRACTS, OLEORESINS, CONDIMENTS, COLORANTS, FLAVORING SUBSTANCES AND AROMAS FROM AROMATIC PLANT SUBSTANCES, ALFALFA, FLOWERS WITH PIGMENTS, AND VEGETABLES - A method for obtaining natural extracts, oleoresins, colorants flavors and aromas from aromatic plant substances, alfalfa, flowers with pigments, and vegetables, which includes washing the plant substances and vegetables, rinsing with water, milling and sifting the resulting product yielding a pulp phase and a cellulose phase. The pulp phase is transferred to fermentation tanks and a first centrifugation of the fermented pulp phase is then performed yielding two phases: phase (A) containing water, mineral salts and other water-soluble substances, with natural extracts, oleoresins, colorants, aromas and flavors and phase (B) in the form of a paste in which the moisture has been reduced to 50%, performing a second centrifugation of the mentioned phase (A), which causes the separation of natural extracts, oleoresins, colorants, aromas and flavors from the water and other water-soluble substances. | 2012-09-20 |
20120237971 | METHODS, CELLS AND SYSTEMS FOR INCORPORATING NON-CANONICAL AMINO ACIDS INTO PROTEINS - The present disclosure pertains to methods of incorporating one or more non-canonical amino acids into a protein during a translation of the protein in bacterial cells. The present disclosure also pertains to methods of incorporating one or more non-canonical amino acids into a protein during an in vitro translation of the protein. In additional embodiments, the present disclosure pertains to isolated bacterial cells and in vitro translation systems (e.g., cell-free extract systems) for incorporating one or more non-canonical amino acids into a protein during a translation of the protein. | 2012-09-20 |
20120237972 | MAMMALIAN-TYPE GLYCOSYLATION IN PLANTS - The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising a functional mammalian enzyme providing N-glycan biosynthesis that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants. | 2012-09-20 |
20120237973 | PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION - A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases. | 2012-09-20 |
20120237974 | METHOD FOR THE EXPRESSION OF A RECOMBINANT PROTEIN IN A MAMMALIAN CELL - The invention relates to methods for the production of a recombinant protein in a mammalian cell and methods to enhance the production of recombinant proteins in mammalian cells. More in particular, the invention provides a cell for the production of a recombinant protein of interest wherein said cell is permissive to a polyomavirus and wherein said cell comprises the genetic elements A and B wherein A encodes a polyomaviral large T antigen or a functional equivalent thereof and B comprises a gene encoding a protein of interest under the functional control of a polyomaviral origin of replication or a functional equivalent thereof, wherein said cell lacks the capability to express a polyomaviral small T antigen or a functional equivalent thereof as well as the capability to express a polyomavirus capsid protein. | 2012-09-20 |
20120237975 | ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF - Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins. | 2012-09-20 |
20120237976 | MAMMALIAN EXPRESSION VECTORS AND USES THEREOF - The present invention features nucleic acids for recombinant protein expression in mammalian cell culture. The episomal vectors of the invention promote high protein production in mammalian cells expressing the SV40 T Ag or Epstein-Barr virus nuclear antigen (e.g., COS7 or HEK293-6E cells). The methods and systems are useful, for example, in pharmaceutical drug development and cloning, especially for the production of antibodies. | 2012-09-20 |
20120237977 | Activatable Binding Polypeptides and Methods of Identification and Use Thereof - Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use. | 2012-09-20 |
20120237978 | GPCR Fusion Protein Containing an N-Terminal Autonomously Folding Stable Domain, and Crystals of the Same - Certain embodiments provide a GPCR fusion protein. In particular embodiments, the GPCR fusion protein comprises: a) a G-protein coupled receptor (GPCR); and b) an autonomously folding stable domain, where the autonomously folding stable domain is N-terminal to the GPCR and is heterologous to the GPCR. The GPCR fusion protein is characterized in that is crystallizable under lipidic cubic phase crystallization conditions. In certain embodiments, the GPCR fusion protein may be crystallizable in a complex with a G-protein or in a complex with an antibody that binds to the IC3 loop of the GPCR. | 2012-09-20 |
20120237979 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2012-09-20 |
20120237980 | CONTINUOUS COUNTER-CURRENT ORGANOSOLV PROCESSING OF LIGNOCELLULOSIC FEEDSTOCKS - A modular process for organosolv fractionation of lignocellulosic feedstocks into component parts and further processing of said component parts into one or more of a de-lignified cellulose stream, a sugar stream, small-chain alcohol streams and four structurally distinct classes of lignin derivatives. The modular process comprises a first processing module configured for digesting lignocellulosic feedstocks with an organic solvent thereby producing a cellulosic solids fraction and a liquid fraction, a second processing module configured for recovering small-chain alcohols and optionally a first class of lignin derivatives from the cellulosic solids fraction, a third processing module configured for recovering from the liquid fraction at least one of a second class and a third class of lignin derivatives or mixtures thereof, and waste stream comprising a fourth class of lignin derivatives. The fourth processing module may optionally recover the fourth class of lignin derivatives. | 2012-09-20 |
20120237981 | AMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch into sugars. In one aspect, the invention provides delayed release compositions comprising a desired ingredient coated by a latex polymer coating. | 2012-09-20 |
20120237982 | Glucoamylase Variants - The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates. | 2012-09-20 |
20120237983 | METHOD FOR INTRODUCING CELLULASE ENZYME TO LIGNOCELLULOSIC FEEDSTOCK SLURRY - The present invention provides a method for producing glucose from a lignocellulosic feedstock. The method comprises the steps of (i) providing a pretreated lignocellulosic feedstock slurry; (ii) moving the pretreated feedstock slurry through a pipe, which slurry has an undissolved solids content of between about 15 and about 30 wt %; (iii) adding cellulase enzyme to the pretreated slurry to produce a slurry comprising cellulase enzyme; (iv) dispersing the cellulase enzyme added in step (iii) in the pretreated slurry by using a high shear in-line mixing device, thereby producing a pretreated slurry comprising dispersed cellulase enzyme; and thereafter (v) subjecting the pretreated slurry comprising dispersed cellulase enzyme to hydrolysis so as to produce glucose from cellulose contained therein. | 2012-09-20 |
20120237984 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation. | 2012-09-20 |
20120237985 | METHOD FOR PRODUCING L-AMINO ACID - A method for producing an L-amino acid by culturing a coryneform bacterium having an L-amino acid-producing ability in a medium to produce and accumulate the L-amino acid in the medium or cells of the bacterium, and collecting the L-amino acid from the medium or cells, wherein said coryneform bacterium has been modified to enhance carbonic anhydrase activity. | 2012-09-20 |
20120237986 | METHOD FOR PRODUCING AN L-CYSTEINE, L-CYSTINE, A DERIVATIVE OR PRECURSOR THEREOF OR A MIXTURE THEREOF USING A BACTERIUM OF ENTEROBACTERIACEAE FAMILY - The present invention provides a method for producing L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof using a bacterium of Enterobacteriaceae family which has been modified to have enhanced expression of the genes involved in the process of sulphur assimilation. | 2012-09-20 |
20120237987 | BACTERIUM FOR PRODUCTION OF FATTY ACIDS - The present invention encompasses a bacterium that produces fatty acids. | 2012-09-20 |
20120237988 | BUTANOL STRAIN IMPROVEMENT WITH INTEGRATION OF A POLYNUCLEOTIDE ENCODING A POLYPEPTIDE THAT CATALYZES PYRUVATE TO ACETOLACTATE CONVERSION - The invention relates to recombinant host cells having at least one integrated polynucleotide encoding a polypeptide that catalyzes a step in a pyruvate-utilizing biosynthetic pathway, e.g., pyruvate to acetolactate conversion. The invention also relates to methods of increasing the biosynthetic production of isobutanol, 2,3-butanediol, 2-butanol or 2-butanone using such host cells. | 2012-09-20 |
20120237989 | SEPARATION OF LIGNIN FROM HYDROLYZATE - A method for the production water insoluble reactive lignin having low sulfur content and lignosulfonates from lignocellulosic material in a batch or continuous process. Lignocellulosic material is fractionated to produce water insoluble native lignin and lignosulfonates in various ratios, while preserving the cellulose and hydrolyzed hemicelluloses using water, ethanol and sulfur dioxide. | 2012-09-20 |
20120237990 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF FUMARATE, MALATE, AND ACRYLATE - A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme. The one or more gene disruptions confers increased production of acrylate onto the organism. Organisms that produce acrylate have an acrylate pathway that at least one exogenous nucleic acid encoding an acrylate pathway enzyme expressed in a sufficient amount to produce acrylate, the acrylate pathway comprising a decarboxylase. Methods of producing fumarate, malate or acrylate include culturing these organisms. | 2012-09-20 |
20120237991 | Method for the biocatalytic cyclization of terpenes and cyclase mutants employable therein - The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene. | 2012-09-20 |
20120237992 | ISOPROPYL ALCOHOL-PRODUCING BACTERIUM AND METHOD FOR PRODUCING ISOPROPYL ALCOHOL - The present invention provides an isopropyl alcohol-producing | 2012-09-20 |
20120237993 | Polypeptides Having Cellobiohydrolase 1 Activity and Polynucleotides Encoding Same - The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides. | 2012-09-20 |
20120237994 | BIOCHARS, METHODS OF USING BIOCHARS, METHODS OF MAKING BIOCHARS AND REACTORS - Embodiments of the present disclosure provide for biochar impregnated with microbes, methods of making biochar impregnated with microbes, methods of using biochar impregnated with microbes, methods of using biochar to produce gas, reactors using biochar and/or biochar impregnated with microbes, methods of using the reactors, and the like. | 2012-09-20 |
20120237995 | PROCESS OF TREATMENT FOR OXIDIZING AN ACIDIC SOLUTION CONTAINING AN IODIDE ION AND AN IRON (II) ION - [Problem to be Solved] | 2012-09-20 |
20120237996 | Method for Producing Grown Materials and Products Made Thereby - The composite material is comprised of a substrate of discrete particles and a network of interconnected mycelia cells bonding the discrete particles together. The mycelia cells are selected from the group consisting of at least one of | 2012-09-20 |
20120237997 | LABEL-FREE CELLULAR MANIPULATION AND SORTING VIA BIOCOMPATIBLE FERROFLUIDS - A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic Channel length. The present invention also includes a method of using said device for separating at least one cell type. | 2012-09-20 |
20120237998 | Conjugation Reactions - We describe methods that allow either carbodiimides or other carboxyl-reactive substances to be mixed with solutions of carboxylic acids or phosphates or amines or combinations thereof, so as to form a homogeneous mixture which is then dried, preferably in a freeze drying process. The mixture is then contacted with an entity, which preferably involves the dissolution of the mixture with a buffered solution of the entity, so as to initiate a conjugation reaction between the entity and a component in the mixture. | 2012-09-20 |
20120237999 | HERPES SIMPLEX VIRUSES AND METHODS OF VIRAL REPLICATION - A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide. | 2012-09-20 |
20120238000 | IMMORTALIZED AVIAN CELL LINES - This invention relates to immortalized avian cells, including those deposited under accession numbers 09070701, 09070702, and 09070703 at the ECACC, and to the use of these cells for the production of viruses. The cells according to the invention are particularly useful for the production of recombinant viral vectors which can be used for the preparation of therapeutic and/or prophylactic compositions for the treatment of animals and more particularly humans. | 2012-09-20 |
20120238001 | PRODUCTION OF VIRAL VACCINES IN SUSPENSION ON AVIAN EMBRYONIC DERIVED STEM CELL LINES - The present invention relates to the development and manufacturing of viral vaccines. In particular, the invention relates to the field of industrial production of viral vectors and vaccines, more in particular to the use of avian embryonic stem cells, preferably the EBx® cell line derived from chicken embryonic stem cells, for the production of viral vectors and viruses. The invention is particularly useful for the industrial production of viral vaccines to prevent viral infection of humans and animals. | 2012-09-20 |
20120238002 | Photobioreactors Comprising Membrane Carbonation Modules and Uses Thereof - Apparatuses, systems, and methods for using membrane carbonation modules and photobioreactors. Membrane carbonation modules and systems use gas-transfer membranes to supply inorganic carbon for photoautotrophic microorganism growth in a photobioreactor and to withdraw gases from a photobioreactor. | 2012-09-20 |
20120238003 | MICROORGANISM CONCENTRATING APPARATUS AND METHOD - A microorganism-concentrating apparatus according to one embodiment includes a mixing device, a filtering device, and a magnetic separation device. The mixing device is configured to mix an aqueous suspension of microorganisms with a particulate filter aid includes magnetic particles to prepare an aqueous slurry of the microorganisms and the particulate filter aid. The filtering device is configured to filter the aqueous slurry supplied from the mixing device to provide a filter cake includes the microorganisms and the particulate filter aid, and to provide a filtrate. The magnetic separation device is configured to magnetically separate the filter cake supplied from the filtering device into the microorganisms and the particulate filter aid. | 2012-09-20 |
20120238004 | REDUCING INSOLUBLE DEPOSIT FORMATION IN ETHANOL PRODUCTION - The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid salts or phytates to inorganic phosphates to improve metal solubility and reduce deposition within processing equipment. | 2012-09-20 |
20120238005 | STORAGE-STABLE LIQUID WASHING OR CLEANING AGENT CONTAINING PROTEASES - Phosphonate-containing liquid washing or cleaning agent exhibiting advantageous proteolytic activity and improved storage stability comprising a protease having an amino acid sequence which is at least 80% identical to the amino acid sequence stated in SEQ ID NO. 1 and which comprises in position 99 in the numbering according to SEQ ID NO. 1 the amino acid glutamic acid (E) or aspartic acid (D) or the amino acid asparagine (N) or glutamine (Q) or the amino acid alanine (A) or glycine (G) or serine (S). | 2012-09-20 |
20120238006 | PROCESS FOR REMOVAL OF CARBON DIOXIDE FROM A GAS STREAM - A process for reducing the carbon dioxide concentration of a carbon dioxide-containing gas which process includes, in a first stage, contacting the carbon dioxide-containing gas with a treating solution including an alkali metal carbonate and/or hydroxide and with a catalyst to promote the absorption of carbon dioxide to form a second solution including an alkali metal carbonate and bicarbonate and, in a second stage, contacting the second solution with a carbonatable silicate-containing material including an alkaline earth cation capable of forming an insoluble carbonate to produce silica and a solid carbonate including the cation and to regenerate a solution including alkali metal carbonate. | 2012-09-20 |
20120238007 | Culture Bottles with Internal Sensors - Specimen containers incorporating a sensor are provided with features for decreasing the volume of polymer matrix material required for the sensor. Such volume-reducing features can take the form of scallop-like indentations projecting inwards towards the interior of the container formed in the transition between the side wall of the container and the base of the container. Alternatively, the base of the container includes a raised rim extending upwards into the interior of the body inward of and spaced from the side wall. The rim defines a chamber for the sensor. Methods of manufacturing specimen containers with cured liquid phase sensor matrix materials are also disclosed. | 2012-09-20 |
20120238008 | Rapid Detection of Pathogens Using Paper Devices - A kit for the rapid detection of pathogens in food supplies. The kit includes a microspot device and one or more indicator reagents to be applied to a well of the microspot device. The employed indicator reagent produces a detectable change upon contact with a pathogen of interest. The microspot device is fabricated from a porous membrane, such as filter paper. A substantially continuous boundary composed of a low melting temperature solid is deposited within the porous membrane extending from the top of the membrane to the bottom of the membrane and defines the peripheral sides of the well. Additionally, a barrier is applied to the bottom of the membrane, thus defining the bottom of the well. The kit can further include growth media for enriching the pathogenic bacteria and instructions for use of the kit employing the microspot device and the one or more indicator reagents. | 2012-09-20 |
20120238009 | BIOSENSOR METHOD AND SYSTEM BASED ON FEATURE VECTOR EXTRACTION - A system for biosensor-based detection of toxins includes providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal. | 2012-09-20 |
20120238010 | AUTOMATED BIOLOGICAL GROWTH AND DISPENSING APPARATUS - An automated biological growth and dispensing apparatus utilizing a modular growing tank which is removable for replacement by another growing tank. Mechanisms for the delivery of air, water and/or nutrients are adapted to permit the growing tank to be readily coupled and uncoupled for easy and inexpensive replacement. Mechanisms for agitation may be integral and removable with the growing tank or may be adapted for a quick connection and disconnection with the growing tank. The growing tank may be disposable and each new growing tank may be provided as a sealed container including a starting amount of a biomass and/or nutrient. | 2012-09-20 |
20120238011 | CONTINUOUS RECOVERY HARVEST BAG - Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor. | 2012-09-20 |
20120238012 | CYTOTOXIC T LYMPHOCYTE - The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte. | 2012-09-20 |
20120238013 | FUSION PARTNER FOR PRODUCTION OF MONOCLONAL RABBIT ANTIBODIES - The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, in certain embodiments, an altered immunoglobulin heavy chain-encoding gene. A hybridoma resulting from fusion between the subject immortal B-lymphocyte and a rabbit antibody-producing cell is provided, as is a method of using that hybridoma to produce an antibody. The subject invention finds use in a variety of different diagnostic, therapeutic and research applications. | 2012-09-20 |
20120238014 | Pluripotent Cells from the Mammalian Late Epiblast Layer - The invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal species. | 2012-09-20 |
20120238015 | METHODS AND MATERIALS FOR INCREASING POTENCY OF CELLS - Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage. | 2012-09-20 |
20120238016 | Specific nNOS Inhibitors for the Therapy And Prevention Of Human Melanoma - Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies. | 2012-09-20 |
20120238017 | NOVEL SIRNA STRUCTURE FOR MINIMIZING OFF-TARGET EFFECTS AND RELAXING SATURATION OF RNAI MACHINERY AND THE USE THEREOF - The present invention relates to a novel siRNA structure and the use thereof. More particularly, the invention relates to a double-stranded small interfering RNA molecule (siRNA molecule) comprising a 19-21 nucleotide (nt) antisense strand and a 15-19 nt sense strand having a sequence complementary to the antisense sequence, wherein the 5′ end of the antisense strand has a blunt end and the 3′ end of the antisense strand has an overhang, and to a method for silencing the expression of a target gene using the siRNA molecule. | 2012-09-20 |
20120238018 | Caged Ceramide-1-Phosphate Derivatives - The invention relates to novel caged ceramide 1-phosphate (C1P) and the method of using them for delivering C | 2012-09-20 |
20120238019 | STEM CELL CULTURE MEDIA FOR MAINTAINING STEMNESS OR INDUCING DIFFERENTIATION OF STEM CELLS - The present invention provides a medium for maintaining stemness of stem cells comprising a protein kinase C inhibitor in a basal medium; and a method for culturing stem cells while maintaining stemness thereof, using the same. And also, the present invention provides a medium for inducing differentiation of stem cells comprising a protein kinase C activator in a basal medium; and a method for inducing differentiation of stem cells, using the same. | 2012-09-20 |
20120238020 | Megakaryocyte and Platelet Production from Stem Cells - Methods for obtaining purified populations of megakaryocytes and platelets by ex vivo culture of stem cells are provided herein. | 2012-09-20 |
20120238021 | METHODS OF SYNTHESIZING THREE-DIMENSIONAL HETEROATOM-DOPED CARBON NANOTUBE MACRO MATERIALS AND COMPOSITIONS THEREOF - Methods for synthesizing macroscale 3D heteroatom-doped carbon nanotube materials (such as boron doped carbon nanotube materials) and compositions thereof. Macroscopic quantities of three-dimensionally networked heteroatom-doped carbon nanotube materials are directly grown using an aerosol-assisted chemical vapor deposition method. The porous heteroatom-doped carbon nanotube material is created by doping of heteroatoms (such as boron) in the nanotube lattice during growth, which influences the creation of elbow joints and branching of nanotubes leading to the three dimensional super-structure. The super-hydrophobic heteroatom-doped carbon nanotube sponge is strongly oleophilic and an soak up large quantities of organic solvents and oil. The trapped oil can be burnt off and the heteroatom-doped carbon nanotube material can be used repeatedly as an oil removal scaffold. Optionally, the heteroatom-doped carbon nanotubes in the heteroatom-doped carbon nanotube materials can be welded to form one or more macroscale 3D carbon nanotubes. | 2012-09-20 |
20120238022 | INDUCIBLE SYSTEMS AND METHODS FOR CONTROLLING siRNA EXPRESSION - An inducible system and methods for controlling expression of siRNA are provided. An inducible system for producing siRNA only in the presence of HIV TAT, and methods for inhibiting HIV-1 gene expression in cells comprising such inducible system also are provided. | 2012-09-20 |
20120238023 | Novel Method for Producing Differentiated Cells - The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed. | 2012-09-20 |
20120238024 | Anti-Microbial Biotherapeutic Agents: Alternatives to Conventional Pharmaceutical Antibiotics - Novel antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill targeted pathogenic bacteria, but are not harmful to donor bacteria. Two types of lethal transmissible plasmids are disclosed. One type kills recipient bacteria by unchecked (“runaway”) replication in the recipient cells and is prevented from occurring in donor cells. Another type kills recipient bacteria by expressing a gene that produces a product detrimental or lethal to recipient bacterial cells, that gene being prevented from expression in donor cells. | 2012-09-20 |
20120238025 | SYNTHETIC URINE AND METHOD FOR MANUFACTURING SYNTHETIC URINE - A synthetic urine solution is described. The synthetic urine solution is a shelf stable, food grade composition formed of water having a pH between 3 and 10. A thickening agent is dissolved within the water to form a solution having a specific gravity between 1.025 g/cm | 2012-09-20 |
20120238026 | BLOOD COAGULATION SYSTEM ANALYZING METHOD AND BLOOD COAGULATION SYSTEM ANALYZING DEVICE - A blood coagulation system analyzing method includes acquiring information relating to the coagulability of blood based on a change generated in a complex permittivity spectrum measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood. | 2012-09-20 |
20120238027 | Methods and Systems for Determining the Presence or Amount of Testosterone in a Sample - Disclosed are methods and systems for the analysis of testosterone in a sample using supported liquid extraction and liquid chromatography-mass spectrometry. | 2012-09-20 |
20120238028 | Means and Methods for Diagnosing Multiple Sclerosis - The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing multiple sclerosis in a subject, a method for identifying whether a subject is in need for a therapy of multiple sclerosis or a method for determining whether a multiple sclerosis therapy is successful. Moreover, contributed is a method for diagnosing or predicting the risk of an active status of multiple sclerosis in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices. | 2012-09-20 |
20120238029 | COMPOSITION FOR MEASURING THE BINDING AFFINITY BETWEEN NUCLEIC ACID AND TEST SUBSTANCE, AND USE THEREOF - In one embodiment of the present invention, a composition is disclosed for measuring a binding affinity between a nucleic acid and a test substance, which contains an organic fluorescent substance capable of binding to an RNA and which emits fluorescence having an intensity greater while the organic fluorescent substance is liberated from an RNA than while the organic fluorescent substance is bound to an RNA. This enables a highly accurate and easy measurement of a binding affinity between a test substance and a nucleic acid, and allows various substances to be examined as a test substance. | 2012-09-20 |
20120238030 | Methods and Systems for Multiplex Analysis of Biomolecules by Liquir Chromatography-Mass Spectrometry - Multiplex analysis methods for rapid analysis of the presence or amount of two or more biomolecules in a sample are disclosed. Systems implementing such methods are further disclosed. | 2012-09-20 |
20120238031 | Conversion of Nitrogen Dioxide (NO2) to Nitric Oxide (NO) - Various systems, devices, NO | 2012-09-20 |
20120238032 | LAB ON A CHIP - A Lab On a Chip (LOC) has a Sample Preparation Module (SPM) coupled to a sample inlet, a microchannel coupled to the SPM, and an optic module optically proximate to the microchannel. The optic module holds multiple lenses, each of which has a different effective focal length, such that all fields of focus within the microchannel are covered as objects suspended within the liquid sample pass through the microchannel. | 2012-09-20 |
20120238033 | FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS - Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use. | 2012-09-20 |
20120238034 | DILUENT WELLS PRODUCED IN CARD FORMAT FOR IMMUNODIAGNOSTIC TESTING - An immunodiagnostic test card includes a flat planar member and at least one dilution chamber that is supported by the flat planar member. The at least one dilution chamber can be disposed adjacent chambers used for testing a patient sample that are provided on the immunodiagnostic test card or can be provided separately. | 2012-09-20 |
20120238035 | MULTICOLOR MICROWAVE-ACCELERATED METAL-ENHANCED FLUORESCENCE (M-MAMEF) - The present invention relates to the use of multiple different light emitting molecules that emit different and detectable emission signals to provide systems and methods to detect different target products in a single assay sample, wherein the different light emitting molecules are positioned an optimal distance from metallic particles thereby enhancing emissions. Preferably, the systems and methods further comprise use of either microwave or sonic energy to increase binding reactions, timing of such reactions within the assay sample and reduce background non-specific biological absorption. | 2012-09-20 |
20120238036 | METHOD FOR IMMOBILIZING PROTEIN A ON A SELF-ASSEMBLED MONOLAYER - The object of the present invention is to provide a method for increasing an amount of Protein A to be immobilized on the self-assembled monolayer. Immobilizing Protein A to the self-assembled monolayer through the structure represented following formula (II) obviates the object. | 2012-09-20 |