38th week of 2014 patent applcation highlights part 140 |
Patent application number | Title | Published |
20140273186 | METHOD AND APPARATUS FOR SEQUENCING MOLECULES - The invention comprises a polymer sequencing chip. In one embodiment, an open nano channel is used in the surface of a semiconductor material or glass as a conduit for the polymer and the resulting monomers released from the polymer. As the resulting monomers pass through the nano channel, a detection device reads the sequence of monomers. Preferably, multiple micro LEDs are used to emit a signal when different monomer units pass through a region of the nano channel, such that multiply parallel sequencing operations can be conducted at the same time on a chip. | 2014-09-18 |
20140273187 | POINT OF CARE SENSOR SYSTEMS - Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms. | 2014-09-18 |
20140273188 | IMAGE ANALYSIS AND MEASUREMENT OF BIOLOGICAL SAMPLES - Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples. | 2014-09-18 |
20140273189 | TEST STRIP DETECTION SYSTEM - A test strip detection system, comprising a test strip card ( | 2014-09-18 |
20140273190 | MICRO-CHANNEL CHIP - A micro-channel chip comprises two gas control channels, a liquid inlet channel, a liquid outlet channel, a piston channel, and a micro pump including two micro-valves and a plurality of micro-channels. One of the gas control channels communicates with one end of the piston channel and communicates with the two micro valves and the liquid inlet channel respectively via the micro-channels. The other one of the gas control channels communicates with the two micro-valves and the liquid outlet channel respectively via the micro-channels. The other end of the piston channel communicates with one of the micro-valves via the micro-channels. | 2014-09-18 |
20140273191 | Cell Incubator and Cellular Culture Laboratory Test bed - A cell incubation system and methods for using a cell incubation system are described. The incubator system comprises an incubation compartment for receiving a microplate for processing samples. The microplate comprises a plurality of wells, each of the plurality of wells including a collection chamber, and a plurality of fluidic structures coupled to the plurality of wells. The microplate further comprises a plurality of sensors coupled to the plurality of wells. | 2014-09-18 |
20140273193 | Electrokinetic Microfluidic Flow Cytometer Apparatuses with Differential Resistive Particle Counting and Optical Sorting - The present invention provides electrokinetic microfluidic cytometers useful for detecting and/or sorting fluid-borne particles. In some embodiments, the electrokinetic microfluidic flow cytometer apparatus comprises a substrate having a microchannel formed therein, a particle-sensing gate that reduces the cross-sectional area of a portion of the microchannel, a pair of signal- and noise-detection electrodes, and a particle-detection circuit that is electrically connected to the signal- and noise-detection electrodes and is configured to generate a particle-detection signal responsive to differences in resistivity across the particle-sensing gate. | 2014-09-18 |
20140273194 | SYSTEM FOR IMAGING CAPTURED CELLS - A system for imaging captured cells comprising: an illumination module configured to illuminate a target object; a platform configured to position the target object in relation to the illumination module; a filter module configured to filter light transmitted to the target object and/or to filter light received from the target object, an optical sensor configured to receive light from the target object and to generate image data; and a focusing and optics module configured to manipulate light transmitted to the optical sensor. The system can further comprise one or more of: a control system configured to control at least one of the illumination module, the platform, the focusing and optics module, the filter module, and the optical sensor; a tag identifying system configured to identify and communicate tag information from system elements; a thermal control module configured to adjust temperature parameters of the system; and an image stabilization module. | 2014-09-18 |
20140273195 | FINE PARTICLE MEASURING APPARATUS - A fine particle measuring apparatus is provided. The fine particle measuring apparatus includes a detection unit configured to detect light emitted from a fine particle and a processing unit having a memory device storing instructions which when executed by the processing unit, cause the processing unit to calculate a corrected intensity value of the detected light and generate spectrum data based on the corrected intensity value. | 2014-09-18 |
20140273196 | DIGESTER ASSEMBLY FOR PROVIDING RENEWABLE RESOURCES AND ASSOCIATED SYSTEMS, APPARATUSES, AND METHODS - A renewable energy system includes a digester assembly having an outer tube with an input region and a digestion region. The input region extends above grade and is configured to receive liquid waste. At least a portion of the digestion region is positioned below grade and configured to receive the liquid waste and to anaerobically digest the liquid waste with microorganisms to supply renewable byproducts, such as methane, hydrogen, carbon dioxide, and/or carbon dioxide-rich water. The digester assembly can include two or more deformable tubes that are configured to move liquid through the outer tube by alternatingly compressing one another. In one embodiment, the deformable tubes are configured to replenish waste liquid and to deliver liquid byproducts. In another embodiment, the deformable tubes are configured to exhaust air, such as for delivery of gas byproducts and fostering an anaerobic environment. | 2014-09-18 |
20140273197 | VIBRATABLE CULTURE APPARATUS FOR PROVIDING PLANT CELLS WITH GROWTH ENVIRONMENT - A vibratable culture apparatus includes a culture device and a vibrating device having a driving module and a vibrating module. The vibrating module has a working platform connected to the driving module, a plurality of lighting units installed on the working platform, and a plurality of positioning units. The working platform is vibratable in a plane by the driving module. Each lighting unit has a first LED set used and a second LED set. The positioning units are installed on the working platform and respectively arranged adjacent to the lighting units. The culture device is detachably disposed on the working platform and restricted by at least partial the positioning units for maintaining the relative position between the culture device and the working platform. The culture device is arranged above at least partial the lighting units that used for emitting light to penetrate into the culture device. | 2014-09-18 |
20140273198 | CARTRIDGE FOR NUCLEIC ACID AMPLIFICATION REACION - A cartridge for nucleic acid amplification reaction includes a tube that has a first plug, a second plug formed of a second washing solution washes nucleic acid-binding solid-phase carriers having bound to a nucleic acid, a third plug, a fourth plug formed of a reverse transcription reaction solution which undergoes phase separation when being mixed with oil and in which a reverse transcription reaction occurs, a fifth plug formed of a third oil, a sixth plug formed of an eluate which causes the nucleic acid to be eluted from the nucleic acid-binding solid-phase carriers having bound to the nucleic acid, and a seventh plug in this order in the inside of the tube; a container for nucleic acid amplification reaction that is in communication with the tube and contains oil; and a plunger that pushes liquid to the container for nucleic acid amplification reaction out of the tube. | 2014-09-18 |
20140273199 | System And Method For Producing A Consistent Quality Syngas From Diverse Waste Materials With Heat Recovery Based Power Generation, And Renewable Hydrogen Co-Production - A system and method for converting waste and secondary materials into synthesis gas (syngas) through the use of a molten metal bath gasifier for the initial breakdown of waste feeds and an A/C plasma reactor for complete dissociation of waste feeds into syngas, and an anaerobic digester. The system includes a heat recovery and steam power generation process for the production of electricity. The system produces a net output of electricity above plant load sufficient for the co-production of renewable Hydrogen and Oxygen. The process does not require the use of fossil fuels or fossil feedstocks during normal operations, and it eliminates combustion produced stack emissions or landfill residuals. | 2014-09-18 |
20140273200 | Apparatus for optimizing temperature for fermentation process inside of a variety of enclosures. - An apparatus designed to be placed inside of variety of enclosures to control the temperature inside of the enclosure to create optimal fermentation conditions, consisting of: heater, controller, temperature sensor and optionally a fan. The apparatus fits inside of an independent enclosures of various sizes and types, typically thermally insulated such as existing coolers. Such apparatus placed inside an enclosure can create optimal temperature inside the enclosure for fermentation of various yeast and bacteria as would be used for example in preparation of foods such as yogurt, kimchi, kefir and proofing of baked goods. | 2014-09-18 |
20140273201 | CARTRIDGE FOR NUCLEIC ACID AMPLIFICATION REACION - A cartridge for nucleic acid amplification reaction includes a tube that has a first plug formed of a oil, a second plug formed of a first washing solution which washes nucleic acid-binding solid-phase carriers having bound to a nucleic acid, a third plug formed of a oil, a fourth plug formed of an eluate which causes the nucleic acid to be eluted from the nucleic acid-binding solid-phase carriers, a fifth plug formed of a oil, a sixth plug formed of a nucleic acid amplification reaction solution which causes a nucleic acid amplification reaction, and a seventh plug formed of a oil in this order in the inside of the tube; a container for nucleic acid amplification reaction that contains oil; and a plunger that pushes liquid to the container for nucleic acid amplification reaction out of the side of the seventh plug of the tube. | 2014-09-18 |
20140273202 | CARTRIDGE FOR NUCLEIC ACID AMPLIFICATION REACTION - A cartridge for nucleic acid amplification reaction includes a tube that has a first plug, a second plug formed of a first washing solution which washes nucleic acid-binding solid-phase carriers having bound to a nucleic acid, a third plug, a fourth plug formed of an eluate which causes the nucleic acid to be eluted from the nucleic acid-binding solid-phase carriers having bound to the nucleic acid, and a fifth plug in this order in the inside of the tube; a container for nucleic acid amplification reaction that is in communication with the side of the fifth plug of the tube and contains oil; and a plunger that pushes liquid to the container for nucleic acid amplification reaction out of the side of the fifth plug of the tube. | 2014-09-18 |
20140273203 | Host Cells with Artificial Endosymbionts - The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria. | 2014-09-18 |
20140273204 | Method Of Producing A Paralytic Peptide - The invention relates to recombinant expression vectors encoding a low molecular weight peptide isolated from the submaxiliary saliva glands of shrews of the species | 2014-09-18 |
20140273205 | ANIMAL CELL CULTURE MEDIA COMPRISING NON ANIMAL OR PLANT DERIVED NUTRIENTS - The present invention provides serum-free cell culture media formulations which are capable of supporting the in vitro cultivation of animal cells. The media comprise at least one nutrient of non-animal derivation, such as at least one plant peptide and/or at least one non-animal or plant lipid and/or fatty acid. The media may further optionally comprise an enzymatic digest or extract of yeast cells. The present invention also provides methods of cultivating animal cells in vitro using these cell culture media formulations. In addition, the media of the present invention can be used for growth of animal cells for virus production. | 2014-09-18 |
20140273206 | HIGH DENSITY CELL BANKING METHODS - The current disclosure provides a method for the creation of a high-density cryopreserved cell bank using perfusion culture techniques and non-centrifugal concentration of cells. Methods of production using this high-density cryopreserved cell bank are also provided. | 2014-09-18 |
20140273207 | LABEL-FREE IDENTIFICATION OF STEM CELL-DIFFERENTIATED CELLS - Methods are disclosed for isolation of a stem-cell derived differentiated cell, which method entails illuminating an incident light onto a plurality of stem-cell derived cells that comprise at least an undifferentiated cell and a differentiated cell possessing a noncentrosymmetric structure, wherein the differentiated cell generates second-harmonic light from the incident light; and isolating the differentiated cell identified by the second-harmonic light. Devices for carrying out the methods are also provided. | 2014-09-18 |
20140273208 | RECOMBINANT PROTEIN EXPRESSION USING A HYBRID CHEF1 PROMOTER - The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-α (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems. | 2014-09-18 |
20140273209 | ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE - The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system. | 2014-09-18 |
20140273210 | HIGH THROUGHPUT MECHANICAL STRAIN GENERATING SYSTEM FOR CELL CULTURES AND APPLICATIONS THEREOF - The present application relates to an adaptable cell culture system that allows the application of mechanical strain to cells in culture through the displacement of a stretchable cell culture substrate. The system can apply dynamically heterogeneous strains to simulate the complex in vivo strain profiles on cultured cells, the strains including simulation of physiologic waveform such as a simulation of normal or diseased physiological biphasic stretch of the cardiac cycle, a simulation of normal or diseased physiological arterial waveform, or a cyclic mechanical strain. The system is modular and compatible with commercially available cell culture plate formats and robotic liquid handling devices. The system has a variety of applications including screening compounds for cardio toxicity or therapeutic activity, and identifying drug target, all using cell culture under the mechanical strain applied by the system. | 2014-09-18 |
20140273211 | Methods and Materials for Hematoendothelial Differentiation of Human Pluripotent Stem Cells Under Defined Conditions - Methods and compositions for differentiating pluripotent stem cells into cells of endothelial and hematopoietic lineages are disclosed. | 2014-09-18 |
20140273212 | EXPANSION OF ADULT STEM CELLS IN VITRO - Disclosed are methods for manipulating and expanding stem cell populations, including adult stem cells, the cells produced by such methods, and various protein constructs related thereto. | 2014-09-18 |
20140273213 | CONSERVED HBV AND HCV SEQUENCES USEFUL FOR GENE SILENCING - Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the viruses in mammalian cells, are provided. These sequences are useful to silence the genes of HBV and HCV, thereby providing therapeutic utility against HBV and HCV viral infection in humans. | 2014-09-18 |
20140273214 | STEM CELL CULTURES - The present invention relates compounds for stabilizing cells and methods of their use. | 2014-09-18 |
20140273215 | METHODS AND COMPOSITIONS FOR TARGETED RELEASE OF MOLECULES FROM NANOSCALE CARRIERS - The present disclosure relates generally to the field of nanoscale materials, and more specifically to the field of nanoscale materials for activating delivered molecules at a target location. | 2014-09-18 |
20140273216 | Synthetic Lariat RNA for RNA Interference - Provided herein are compositions for the modification of gene expression by RNA interference using a microRNA (miRNA) guide strand precursor. Methods of making and using the miRNA guide strand precursor also are provided. The compositions bypass the Drosha-Exportin-Dicer pathway and are resistant to nucleases. | 2014-09-18 |
20140273217 | PRODRUG ACTIVATION IN CANCER CELLS USING MOLECULAR SWITCHES - The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a prodrug activating enzyme and a protein that binds a cancer specific marker, polynucleotides encoding the polypeptides, and molecular switches for converting a prodrug into a toxin, comprising the polypeptides. The invention also features methods for converting a prodrug into a toxin, methods for treating cancer, and methods for making the molecular switches, as well as kits. | 2014-09-18 |
20140273218 | SYSTEMS AND METHODS FOR AN ADVANCED MEDICAL DEVICE - The present invention relates to a biologically active medical device, which includes a matrix seeded with progenitor cells, and then covered by ciliated tissue. The matrix is capable of enabling cellular migration. The ciliated tissue is ependymal cells that express at least one of tight junctional complexes, zonula adherens, and gap junctions. The progenitor cells include subpendymal progenitor cells. In some cases the progenitor cells include stem cells, and the ciliated tissue includes at least one of Choroid cells, tanacytes, and circumventricular organs. In some embodiments, the medical device is oriented into a tubular structure in order to form a cerebrospinal shunt. Additional cells and structures may be imbedded within the matrix, such as glia, endothelial cells, stem cells, and blood vessels. The medical device may also be incorporated into a bioreactor including a flexible inner tube defining an anthropomorphically shaped lumen. | 2014-09-18 |
20140273219 | DIFFERENTIATED CELLULAR COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE - The present invention relates to methods for culturing progenitor cells to differentiate primarily into a single population of cells with the same phenotype, and to compositions thereof. In particular, it relates to methods for culturing liver progenitor cells to differentiate primarily into a single population of hepatocyte-like cells, and to compositions thereof. | 2014-09-18 |
20140273220 | Self-Organized Vascular Networks from Human Pluripotent Stem Cells in a Synthetic Matrix - A bicellular vascular population derived from human pluripotent stem cells (hPSCs) undergoes morphogenesis and assembly in a synthetic hydrogel. It is shown that hPSCs can be induced to co-differentiate into early vascular cells (EVCs) in a clinically-relevant strategy dependent upon Notch activation. These EVCs mature into ECs and pericytes, and self-organize to form vascular networks in an engineered matrix. Upon in vivo implantation, multicellular human vascular networks are functionally perfused. Thus, a derived bicellular population is exploited for its intrinsic self-assembly capability to create functional microvasculature in a deliverable matrix. | 2014-09-18 |
20140273221 | SUBSTRATES FOR GENERATION OF CONTROLLED HUMAN PLURIPOTENT STEM CELL COLONY SIZE AND SHAPE - Methods of cell culture using patterned SAM arrays are disclosed. Advantageously, the disclosed methods use SAM arrays presenting adhesion peptides to grow confluent monolayers that can invaginate to form an embryoid body. | 2014-09-18 |
20140273222 | BIOREACTORS FOR TUBULAR ORGANS - In one embodiment, a bioreactor includes a cartridge adapted to deliver growth media to inner and outer surfaces of a tubular organ scaffold, the cartridge having a container that includes a first passage adapted to deliver a first growth medium to the inner surfaces of the tubular organ scaffold and a second passage adapted to deliver a second growth medium to the outer surfaces of the scaffold, wherein the first and second growth media are different media. | 2014-09-18 |
20140273223 | MICRO-DEVICE FOR CULTURING CELLS, METHOD FOR MANUFACTURING SAME, AND METHOD FOR CULTURING CELLS USING THE MICRO-DEVICE FOR CULTURING CELLS - Disclosed is micro-device for culturing cells comprising: a plurality of fluid paths through which fluid moves; and at least one inlet port for injecting fluid to the fluid paths, said fluid paths communicating with each other and being different in height from each other. In the cell culture device having a plurality of fluid paths, cells can be cultured by introducing a polymeric material to at least one fluid path having a relatively low height; solidifying the polymeric material to form a 3-dimensional scaffold; and injecting fluid for cell culture to a fluid path in contact with the 3-dimensional scaffold. | 2014-09-18 |
20140273224 | ARTIFICIAL AND MUTATED NUCLEOTIDE SEQUENCES - The present invention relates to artificial nucleotide sequences, including specific mutations therein. | 2014-09-18 |
20140273225 | NUCLEOSOME-EXCLUDING SEQUENCES (NES) AS A DNA SPACER IN VECTORS RESULTS IN PROLONGED TRANSGENE EXPRESSION IN EUKARYOTIC CELLS - The silencing effect of a spacer sequence, for example a bacterial backbone sequence in a plasmid or other episomal vector, on transgene expression is reversed by engineering of the spacer to include nucleosome exclusion sequences. | 2014-09-18 |
20140273226 | CRISPR/CAS SYSTEMS FOR GENOMIC MODIFICATION AND GENE MODULATION - The invention relates to engineered CRISPR/Cas9 systems for genomic modification and regulation of gene expression in mammalian cells. The specification describes the design and validation of polynucleotides encoding the | 2014-09-18 |
20140273227 | GSK3 Ligands and Polynucleotides Encoding GSK3 Ligands - The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate GSK3 activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands. | 2014-09-18 |
20140273228 | METHOD FOR PROPAGATING ADENOVIRAL VECTORS ENCODING INHIBITORY GENE PRODUCTS - The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector. | 2014-09-18 |
20140273229 | INTRACELLULAR DELIVERY AND TRANSFECTION METHODS AND DEVICES - Embodiments of the present disclosure provide a multistage procedure for treatment of biological samples (e.g., living cells with membranes, and the like) with a substance (e.g., a drug, DNA, RNA, plasmids, and other biomolecules or materials) to achieve more efficacious intracellular delivery and transfection. | 2014-09-18 |
20140273230 | CRISPR-BASED GENOME MODIFICATION AND REGULATION - The present invention provides methods for modifying chromosomal sequences. In particular, methods are provided for using RNA-guided endonucleases or modified RNA-guided endonucleases to modify targeted chromosomal sequences. | 2014-09-18 |
20140273231 | CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. | 2014-09-18 |
20140273232 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system. | 2014-09-18 |
20140273233 | CRISPR-BASED GENOME MODIFICATION AND REGULATION - The present invention provides methods for modifying chromosomal sequences. In particular, methods are provided for using RNA-guided endonucleases or modified RNA-guided endonucleases to modify targeted chromosomal sequences. | 2014-09-18 |
20140273234 | ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme. | 2014-09-18 |
20140273235 | ENGINEERING PLANT GENOMES USING CRISPR/Cas SYSTEMS - Materials and methods for gene targeting using Clustered Regularly Interspersed Short Palindromic Repeats/CRISPR-associated (CRISPR/Cas) systems are provided herein. | 2014-09-18 |
20140273236 | Use of Clostridial Methyltransferases for Generating Novel Strains - This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts. | 2014-09-18 |
20140273237 | Stable Genomic Integration of Multiple Polynucleotide Copies - Methods of constructing a cell comprising in its chromosome one or more copies of an open reading frame (ORF) or operon encoding at least one polypeptide of interest, each copy being under the transcriptional control of a heterologous promoter using a site specific recombinase and in vivo integration by recombination; means for carrying out the methods, resulting cells, and methods for producing a polypeptide of interest using the resulting cells. | 2014-09-18 |
20140273238 | TRANSCRIPTIONAL CONTROL IN ALICYCLOBACILLUS ACIDOCALDARIUS AND ASSOCIATED GENES, PROTEINS, AND METHODS - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 2014-09-18 |
20140273239 | AIR REMOVAL TEST STRIP - An air removal test system for verifying adequate air removal during a sterilization cycle of a pre-vacuum type sterilizer includes specimen holder and a test strip. The test strip includes a solid indicator chemical, which liquefies and travels along a wicking element during the sterilization cycle. The test strip is configured to verify adequate removal of air during the sterilization cycle by displaying a color change through a window. | 2014-09-18 |
20140273240 | METHOD AND SYSTEM FOR DETECTING EXPOSURE OF COMPOSITES TO HIGH-TEMPERATURE - A method of detecting high-temperature exposure of a composite may include applying a composition comprising an adduct suitable for detecting heat and/or mechanical stress in a composite, wherein the adduct reverts to first and second adduct components after exposure of the composition to a temperature of from about 190° C. to about 260° C. to a surface of the composite; exposing the surface to which the composition has been applied to ultraviolet light; and measuring fluorescence of the composition. | 2014-09-18 |
20140273241 | DIAGNOSTIC ANALYZERS WITH PRETREATMENT CAROUSELS AND RELATED METHODS - Diagnostic analyzers with pretreatment carousels and related methods are disclosed. An example apparatus includes a first carousel that includes a first annular array of slots to receive a first vessel. The example first carousel also includes a first track of rotation about the first carousel having a first diameter and a second track of rotation about the first carousel having a second diameter smaller than the first diameter. The example apparatus includes a first diverter to move the first vessel from the first track to the second track. In addition, the example apparatus includes a second carousel coaxial with the first carousel. The example second carousel includes a second annular array of slots to receive a second vessel. | 2014-09-18 |
20140273242 | AUTOMATED DIAGNOSTIC ANALYZERS HAVING REAR ACCESSIBLE TRACK SYSTEMS AND RELATED METHODS - Example apparatus and methods related to automated diagnostic analyzers having rear accessible track systems. An example apparatus disclosed herein includes an analyzer to perform a diagnostic test, the analyzer having a first side and a second side opposite the first side. The example apparatus includes a loading bay disposed on the first side of the analyzer to receive a first carrier and a pipetting mechanism coupled to the analyzer adjacent the second side. The example apparatus also includes a first carrier shuttle to transport the first carrier from a first location adjacent the loading bay to a second location adjacent the pipetting mechanism and a track disposed adjacent the second side of the analyzer to transfer a second carrier to a third location adjacent the pipetting mechanism. | 2014-09-18 |
20140273243 | WATER HARDNESS MONITORING VIA FLUORESCENCE - Provided are automated methods for measuring soluble magnesium concentration in water using fluorescence. The methods employ the use of a pH-buffered liquid and a magnesium coordinating fluorescing reagent. In certain embodiments, the methods may further employ measuring total hardness concentration of the water by displacing any soluble calcium with soluble magnesium and then re-measuring the soluble magnesium concentration. Optionally, the soluble calcium concentration can be determined by subtracting the measured soluble magnesium concentration from the measured total hardness concentration. | 2014-09-18 |
20140273244 | AUTOMATIC TITRATOR - A system and method for performing automated titrations. An automatic titrator utilizes control devices and sensors adapted for various chemical reactions to perform titrations and determine the content of a desired component of a solution. Batch and continuous mode titrations are possible. Titrant is added to a sample either in varying amounts or rates and a titration endpoint is observed via sensors. Control devices detect when the titration endpoint occurs and calculates the desired content. Various reactions within the solution may be suppressed in order to titrate isolated components individually. | 2014-09-18 |
20140273245 | AUTOMATED DIAGNOSTIC ANALYZERS HAVING VERTICALLY ARRANGED CAROUSELS AND RELATED METHODS - Example automated diagnostic analyzers and methods for using the same are disclosed herein. An example apparatus described herein includes a first carousel rotatably coupled to a base and having a first axis of rotation. The example apparatus includes a second carousel rotatably coupled to the base and vertically spaced over the first carousel such that at least a portion of the second carousel is disposed over the first carousel. In the example apparatus, the second carousel has a second axis of rotation and a plurality of vessels. The example apparatus also includes a pipetting mechanism offset from the second axis of rotation. The example pipetting mechanism is to access the first carousel and the second carousel. | 2014-09-18 |
20140273246 | RARE EARTH SPATIAL/SPECTRAL MICROPARTICLE BARCODES FOR LABELING OF OBJECTS AND TISSUES - Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle. | 2014-09-18 |
20140273247 | METHODS FOR MONITORING CHANGES IN THE CORE OF LIPOPROTEIN PARTICLES IN METABOLISM AND DISEASE - A method is disclosed for measuring the properties of protein and lipoprotein elements in a sample. The method includes the of placing a small volume of a sample into a NMR instrument tuned to measure a particular nucleus, applying a series of radiofrequency pulses with intermittent delays in order to measure spin-spin and/or spin-lattice relaxation time constants from the time-domain decay of the signal, without the use of chemical shifts and without converting data into the frequency domain by Fourier transform or other means, at least partially suppressing the water signal prior to the beginning of a sequence used to record relaxation time constants in the time domain, optionally utilizing relaxation contrast agents or other chemical additives to perturb the solvent water or other elements of the sample, analyzing the exponentially decaying NMR signal in the time domain using multi-exponential analysis, and comparing differences in the relaxation time constants for lipoprotein- or protein-specific elements within a single human subject, or between subjects, to assess normal and abnormal metabolism reflective of increased disease risk or active disease. | 2014-09-18 |
20140273248 | Application of Ca Isotope Analysis to the Early Detection of Metastatic Cancer - Methods using the application of the Ca isotope method for diagnosing and monitoring the progression of cancers that cause bone loss. The methods also can be used for evaluating cancer treatments, such as aromatase inhibitors and other chemotherapeutic agents, for effects on bone density so that treatment can be modified. | 2014-09-18 |
20140273249 | High Range Activated Clotting Time Assay Formulation - High range activated clotting time (HR-ACT) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting. The cartridge is treated with a strong surface treatment process, such as an atmospheric plasma treatment, to increase the hydrophilic property of the test chamber, there may be a significant reduction in the kaolin concentration required to activate the blood sample and initiate the coagulation process. The kaolin concentration may be further reduced if the buffer component used in the buffer saline contains phosphate. The reduction of the kaolin concentration allows more calcium to be released from the kaolin to participate in the clotting process. The combined effect of adding a surface treatment to the cartridge to increase the hydrophilic property of reaction chamber and adding phosphate into buffered saline allows for clot detection of blood samples containing 5˜6 U/mL heparin. | 2014-09-18 |
20140273250 | METHODS FOR THE SELECTIVE DETECTION OF ALKYNE-PRESENTING MOLECULES AND RELATED COMPOSITIONS AND SYSTEMS - Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems. | 2014-09-18 |
20140273251 | COLLOIDAL COOMASSIE STAIN - Colloidal formulation for staining proteins and methods of their use are provided. | 2014-09-18 |
20140273252 | ION MOBILITY MASS SPECTROMETRY TAGS FOR QUANTITATIVE APPLICATIONS AND METHODS THEREOF - Compound tags and shifting agents are provided that find use in ion mobility spectrometry (IMS), mass spectrometry (MS), or a combination of IMS and MS, and which can substantially increase separation of multiple components in complex samples and facilitate quantitative and multiplexed analyses. In some cases, the compounds include a linker and a normalizing group, each including a structural unit and separated by a cleaveable group, and a crown ether. Also provided are methods for analyzing peptides in a sample. In some cases, the method includes coupling the compound to peptides which include a terminal guanidinium moiety capable of forming an intra-molecular complex with the crown ether. | 2014-09-18 |
20140273253 | SYSTEM AND PROCESS FOR QUANTIFYING POTENTIALLY MINERALIZABLE NITROGEN FOR AGRICULTURAL CROP PRODUCTION - The invention is generally directed to a system and process for fluorometrically quantifying potentially mineralizable nitrogen for agricultural crop production. The soil analysis process measures potentially mineralizable nitrogen and calibrates the application of soil-based nitrogen for site or field specific management of nitrogen fertilizers for crops grown on a wide variety of soil textures including sandy loam, silt loam and clay soils. The spectrofluorometric system and process may be utilized for routine soil testing with a lower sample to sample variability, and the automation of the spectrofluorometric system and process allows for simultaneous determination of potentially mineralizable soil organic nitrogen, ammonium and nitrate. | 2014-09-18 |
20140273254 | METHOD, PRODUCT, AND SYSTEM FOR QUANTIFYING THE METHYLATION STATUS OF A NUCLEIC ACID IN A SAMPLE - Methods and systems are described for quantifying the methylation status of nucleic acids in a sample utilizing standardized curves derived from methylation-sensitive HRM data. The standardized curves are generated from HRM curves from a plurality of samples, each sample having a known but different methylation status. In one embodiment, the first negative derivative of each HRM curve from the known samples is plotted and a first value corresponding with a first melt peak and a second value corresponding with a second melt peak from the negative derivative plots are identified. The slope of a line connecting the first and second values for each sample is calculated and used to identify a slope data point that is plotted to generate the standardized curve. In another embodiment, a threshold line that intersects the plurality of HRM curves is generated and the standardized curve is generated from the intersection data points. | 2014-09-18 |
20140273255 | RARE EARTH SPATIAL/SPECTRAL BARCODES FOR MULTIPLEXED BIOCHEMICAL TESTING - Hydrogel microparticles spatially and spectrally encoded using upconverting phosphor nanoparticles are described for use in biochemical testing. In each microparticle, upconversion nanocrystals having spectrally distinguishable emission spectra are disposed in different pardons of an encoding region of the microparticle. | 2014-09-18 |
20140273256 | DISPLAYING STATUS OF A BLOOD GLUCOSE MEASURE BEING TRANSFERRED WIRELESSLY FROM A HANDHELD GLUCOSE METER - Persons with diabetes often carry a handheld glucose meter as well as a portable computing device, such as a mobile phone. Given the close proximity of these two devices, the portable computing device can serve as a data collector for the glucose measures taken by the glucose meter. Improved techniques are set forth for transferring glucose measures automatically and seamlessly to the patient's portable computing device, including displaying a value for the glucose measure along with an identifier for the portable computing device on a display of the glucose meter during the data exchange with the portable computing device. | 2014-09-18 |
20140273257 | TRANSFERRING BLOOD GLUCOSE MEASURES SEAMLESSLY FROM A HANDHELD GLUCOSE METER - Persons with diabetes often carry a handheld glucose meter as well as a portable computing device, such as a mobile phone. Given the close proximity of these two devices, the portable computing device can serve as a data collector for the glucose measures taken by the glucose meter. Improved techniques are set forth for transferring glucose measures automatically and seamlessly to the patient's portable computing device, including transmitting a single glucose measure automatically in response to navigating away from an interface which displays to the glucose measure. | 2014-09-18 |
20140273258 | Functional Element for Arranging in Front of the Active Measuring Region of a Sensor Element - A functional element positioned in front of an active detection region of a sensor element has a compact main body with a gas-side surface, a sensor-side surface, and at least two functional channels located between the gas-side surface and the sensor-side surface. The functional channels have a functionality that is different from one another with respect to a gas that can pass through. Such a functional element allows particularly variable operation of a sensor with great long-term stability. | 2014-09-18 |
20140273259 | Low-Dimensional Material Chemical Vapor Sensors - A method of making a low-dimensional material chemical vapor sensor comprising exfoliating MoS | 2014-09-18 |
20140273260 | Method for Determining Derivatized Analytes in A Separated Biological Fluid - The present invention comprises methods for determining the presence, amount, or concentration of analytes of interest including Vitamin D and other secosteroids from biological samples, through derivatization, with improved speed and ease of analysis and improved sensitivity to mass spectrometry. In a preferred embodiment, the present invention comprises methods for determining the presence, amount, or concentration of analytes of interest, including Vitamin D and other secosteroids from whole human blood, through derivatization, and using a plasma collection device to facilitate collection, separation, and preparation of the sample for derivatization and analysis. | 2014-09-18 |
20140273261 | SENSOR ASSEMBLY AND METHOD FOR SENSING STATUS CONDITION OF ELECTRICAL EQUIPMENT - A sensor assembly is disclosed for sensing a status condition of a liquid-filled electrical equipment such as a transformer. The sensor assembly can include a light source; a first hydrogen detection section, the first hydrogen detection section being optically coupled to the light source for receiving light from the light source, wherein the first hydrogen detection section has a first hydrogen sensitive layer that changes an optical response with respect to the received light depending on whether an amount of hydrogen at the first hydrogen sensitive layer is above or below a first threshold; and a first output section optically coupled to the first hydrogen detection section for receiving light having interacted with the first hydrogen sensitive layer such that the received light depends on the optical response of the first hydrogen sensitive layer. | 2014-09-18 |
20140273262 | CATALYTIC COMBUSTION TYPED GAS SENSOR - Provided is a catalytic combustion typed gas sensor of detecting a combustible gas having a concentration equal to or more than a predetermined value based on a raised electric resistance. Herein, combustion heat generated when a combustible gas contacts to a catalytic metal (or detection element) heated by passing electric current therethrough raises a temperature and electric resistance of the catalytic metal. The electric current is made to pass through the catalytic metal such that the temperature of the catalytic metal becomes a standby temperature which is calculated by subtracting the raised temperature portion from a desorption temperature. The combustion heat is generated when the combustible gas contacts to the catalytic metal. Note the catalytic metal adsorbs a silicone compound via a silicon (Si) poisoning process and then desorbs the resulting adsorbed silicone compound at the desorption temperature. The desorption temperature is set in the range over 350° C. to 600° C. | 2014-09-18 |
20140273263 | DIAGNOSTICS FOR CATALYTIC STRUCTURES AND COMBUSTIBLE GAS SENSORS INCLUDING CATALYTIC STRUCTURES - A combustible gas sensor for detecting a combustible analyte includes a first sensing element including a first conductive element in electrical connection with an electronic circuitry, a first support structure in operative connection with the first conductive element, a catalyst supported on the first support structure for catalyzing a reaction of the analyte, and a system for measuring a variable related to the reactance of the first sensing element. Changes in the measured variable over time provide an indication of an operational status of the first sensing element. | 2014-09-18 |
20140273264 | EPOXY CHEMISTRY DERIVED MATERIALS AS MIXED MODE CHROMATOGRAPHY MEDIA, METHOD FOR THEIR SYNTHESIS AND USE - This invention provides mixed-mode stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations. | 2014-09-18 |
20140273265 | MICROFLUIDIC ANALYTE DETECTION CARTRIDGE DEVICE, SYSTEM AND METHOD - A microfluidic cartridge for assaying an analyte comprises one or more test channels, each having a lumen; one or more reference solution channels in fluid communication with the test channels; one or more sample channels in fluid communication with the test channels; one or more sensors at least partially exposed in the lumen of the test channels; and a processor coupled to the one or more sensors for measuring properties of the analyte to determine at least one of an identity, concentration, dose, and dosage of the analyte. | 2014-09-18 |
20140273266 | REACTOR CELL ASSEMBLY FOR USE IN SPECTROSCOPY AND MICROSCOPY APPLICATIONS - The present disclosure provides a reactor cell assembly that utilizes a novel design and that is wholly or partially manufactured from Aluminum, such that reactions involving Hydrogen, for example, including solid-gas reactions and thermal decomposition reactions, are not affected by any degree of Hydrogen outgassing. This reactor cell assembly can be utilized in a wide range of optical and laser spectroscopy applications, as well as optical microscopy applications, including high-temperature and high-pressure applications. The result is that the elucidation of the role of Hydrogen in the reactions studied can be achieved. Various window assemblies can be utilized, such that high temperatures and high pressures can be accommodated and the signals obtained can be optimized. | 2014-09-18 |
20140273267 | Methods of depleting antibodies directed towards major histocompatibility complex - The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and removing at least the recombinant MHC molecules to which antibodies to said recombinant MHC molecules contained within the sample have bound. This method allows the depletion of one or more specific MHC particularly HLA allele antibodies from a sample. | 2014-09-18 |
20140273268 | PREPARATION OF SAMPLES FOR ANALYSIS - An apparatus for preparation of samples for analysis comprising includes structure ( | 2014-09-18 |
20140273269 | RAPID TEST FOR URINE ALBUMIN AND URINE CREATININE - Disclosed herein is an immunochromatographic system for measuring albumin and creatinine in a urine sample and a reader that detects signals from the test cassette, calculates, and displays the results for albumin concentration, creatinine concentration, and albumin-creatinine ratio. | 2014-09-18 |
20140273270 | DIRECT TEMPERATURE MEASUREMENT OF A TEST STRIP - An optical lateral flow fluid analyte testing device includes a test strip having at least one zone for measuring the concentration of a target analyte in a fluid sample. Devices and methods for facilitating a reliable reading are disclosed. | 2014-09-18 |
20140273271 | FLUORESCENCE IMMUNO-CHROMATOGRAPHY, KIT AND TEST STRIP FOR THE SAME - An immunochromatography carried out by illuminating a fluorescent substance in a membrane with excitation light and detecting fluorescence emitted from the fluorescent substance, the immunochromatography comprising the steps of:
| 2014-09-18 |
20140273272 | ASSAY WITH INTERNAL CALIBRATION - Provided herein are kits and methods for assays with internal calibration. | 2014-09-18 |
20140273273 | BIOMARKERS TO IMPROVE PREDICTION OF HEART FAILURE RISK - The present disclosure relates to the field of laboratory diagnostics. Specifically, methods are disclosed for determining a patient's risk of suffering from heart failure (HF) based on the detection of NT-proBNP, troponin T, and/or a natriuretic peptide. Also disclosed are methods for improving both the accuracy and speed of HF risk models by incorporating biomarker data from patient samples. | 2014-09-18 |
20140273274 | METHODS FOR THE SELECTIVE DETECTION OF ALKYNE-PRESENTING MOLECULES AND RELATED COMPOSITIONS AND SYSTEMS - Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems. | 2014-09-18 |
20140273275 | BIOMARKERS FOR LIVER FIBROSIS - Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules. | 2014-09-18 |
20140273276 | SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER - Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel. | 2014-09-18 |
20140273277 | DEVICE AND ASSOCIATED METHODS FOR PERFORMING LUMINESCENCE AND FLUORESCENCE MEASUREMENTS OF A SAMPLE - An apparatus for measuring the luminescence and the fluorescence of a sample, comprising: a light tight optics box capable of receiving a pipette tip containing a sample; an optical sensor located within the optics box and capable of being disposed in both a luminescence reading position and a fluorescence reading position; an excitation light fiber optic bundle and a sample transmission fiber optic bundle; an excitation light assembly that projects excitation light onto a first terminus end of the excitation light fiber optic bundle; and an in-line filter located along the sample transmission fiber optic bundle. | 2014-09-18 |
20140273278 | G-QUADRUPLEX BINDING ASSAYS AND COMPOUNDS THEREFOR - The present invention provides methods for assaying binding of compounds to G-quadruplex structures. Also provided are methods for screening candidate compounds for use as modulators of G-quadruplex activity, and methods for screening candidate compounds for telomerase inhibitory activity. The invention further provides novel compounds useful in the assays of the invention. | 2014-09-18 |
20140273279 | METHOD FOR DETERMINING THE BINDING CONSTANT OF HIGH AFFINITY COMPOUNDS - The invention relates to a method for determining the binding constant of a compound of interest to proteins comprising the following steps: a) adding the high affinity compound to a two-chamber system, wherein the two chambers are separated by a semipermeable membrane, which is permeable for the compound of interest, and determining the amount of the high affinity compound of interest in one of the chambers after the distribution equilibrium has been reached, b) adding a sink compound to one of the chambers whereby the sink compound can not permeate the membrane, and determining the distribution coefficient of the compound of interest to the sink compound after the distribution equilibrium has been reached, c) adding an unspecific protein to the other chamber, whereby the unspecific protein can not permeate the membrane, and determining the distribution coefficient of the compound of interest to the unspecific protein in presence of a sink compound after the distribution equilibrium has been reached, and d) determining the binding constant of the test compound with the distribution coefficient of steps b) and c). | 2014-09-18 |
20140273280 | METHOD FOR DIAGNOSING CHRONIC SINUSITIS - The present invention provides a method for detecting chronic sinusitis, which comprises measuring the concentration of a periostin protein in blood or nasal secretion collected from a test subject. Thereby, a method for detecting chronic sinusitis, which is capable of detecting chronic sinusitis more simply, more promptly and less invasively, is provided. | 2014-09-18 |
20140273281 | METHOD FOR FORMING BIOCHIPS AND BIOCHIPS WITH NON-ORGANIC LANDINGS FOR IMPROVED THERMAL BUDGET - The present disclosure provides biochips and methods of fabricating biochips. The method includes combining three portions: a transparent substrate, a first substrate with microfluidic channels therein, and a second substrate. Through-holes for inlet and outlet are formed in the transparent substrate or the second substrate. Various non-organic landings with support medium for bio-materials to attach are formed on the first substrate and the second substrate before they are combined. In other embodiments, the microfluidic channel is formed of an adhesion layer between a transparent substrate and a second substrate with landings on the substrates. | 2014-09-18 |
20140273282 | PARALLEL SHUNT PATHS IN THERMALLY ASSISTED MAGNETIC MEMORY CELLS - A thermally assisted magnetic memory cell device includes a substrate, a first electrode disposed on the substrate, a magnetic tunnel junction disposed on the first electrode, a second electrode disposed on the magnetic tunnel junction, a conductive hard mask disposed on the second electrode and a parallel shunt path coupled to the magnetic tunnel junction, thereby electrically coupling the first and second electrodes. | 2014-09-18 |
20140273283 | FORMING MAGNETIC MICROELECTROMECHANICAL INDUCTIVE COMPONENTS - A micro-electromechanical device and method of manufacture are disclosed. A sacrificial layer is formed on a silicon substrate. A metal layer is formed on a top surface of the sacrificial layer. Soft magnetic material is electrolessly deposited on the metal layer to manufacture the micro-electromechanical device. The sacrificial layer is removed to produce a metal beam separated from the silicon substrate by a space. | 2014-09-18 |
20140273284 | THERMALLY ASSISTED MRAM WITH MULTILAYER STRAP AND TOP CONTACT FOR LOW THERMAL CONDUCTIVITY - A mechanism is provided for a thermally assisted magnetoresistive random access memory device (TAS-MRAM). The device includes a magnetic tunnel junction configured to store data, a first multilayer contact structure positioned on one end of the magnetic tunnel junction, and a second multilayer contact structure positioned on an opposite end of the magnetic tunnel junction. The first multilayer contact structure and the second multilayer contact structure each include multiple layers of metals. The multiple layers of metals are structured to inhibit thermal conductivity between the magnetic tunnel junction and surrounding structures, and the multiple layers of metals are structured to electrically conduct electrical current. | 2014-09-18 |
20140273285 | MEMORY ARRAY WITH SELF-ALIGNED EPITAXIALLY GROWN MEMORY ELEMENTS AND ANNULAR FET - A system and method for fabricating a memory array device. An example memory array device includes a plurality of memory cells, each including a FET over a substrate and a memory element over the FET. Each memory element includes a plurality of epitaxially grown memory element layers. The memory array device includes a plurality of gate conductors configured a first axis, in parallel. Each gate conductor laterally surrounds a plurality of FETs of the memory cells along the first axis. The memory array device includes a plurality of bit lines configured along a second axis, in parallel, and electrically coupled to a plurality of memory elements along the second axis. Embodiments of the memory array preserve alignment of crystal lattices beginning from the bottom layers in the FET up to the top active layers in memory element, thus preserving crystal lattice alignment between transistor and memory element. | 2014-09-18 |
20140273286 | STRUCTURE AND FABRICATION OF MEMORY ARRAY WITH EPITAXIALLY GROWN MEMORY ELEMENTS AND LINE-SPACE PATTERNS - A system and method for fabricating a memory array device. An example memory array device includes a plurality of memory cells, each including a FET over a substrate and a memory element over the FET. Each memory element includes a plurality of epitaxially grown memory element layers. The memory elements formed utilizing two etches through all epitaxially grown layers. Each of these etches can be split to two separate processes specific to CMOS transistor etch and to memory element etch. The memory array device includes a plurality of gate conductors configured along a first axis, in parallel. Each FET of the memory cells adjacent to two gate conductors. The memory array device includes a plurality of bit lines configured along a second axis, in parallel, and electrically coupled to a plurality of memory elements along the second axis. | 2014-09-18 |