37th week of 2017 patent applcation highlights part 22 |
Patent application number | Title | Published |
20170260106 | HIGH SURFACE AREA CARBON OPALS AND INVERSE OPALS OBTAINED THEREFROM - Carbon opals, a form of colloidal crystal, are composed of ordered two-dimensional or three-dimensional arrays of Monodispersed Starburst Carbon Spheres (MSCS). Methods for producing such carbon opals include oxidizing as-synthesized MSCS, for example by heating in air, to increase surface charge. Such oxidation is believed to decrease settling rates of a colloidal suspension, enabling formation of an ordered colloidal crystal. Inverse opals, composed of any of a wide variety of materials, and based on a carbon opal template, have a reciprocal structure to a carbon opal. Inverse opals are formed by methods including: forming a carbon opal as described, impregnating a desired material into pores in the carbon opal to produce a hybrid structure, and removing the carbon portion from the hybrid structure. | 2017-09-14 |
20170260107 | METHOD FOR HYDROPHOBICIZING A ZIRCONIA SURFACE - A method of treating a ceramic surface containing zirconia, whereby the ceramic surface is ablated by directing a laser beam with a diameter of 200-400 μm produced by a CO | 2017-09-14 |
20170260108 | FOOD WASTE TREATMENT APPARATUS - The present disclosure suggests a food waste treatment apparatus. A food waste treatment apparatus in accordance with an exemplary embodiment of the present disclosure includes: a housing including a food inlet opening at its top surface; an inner chamber where food introduced through the food inlet opening is collected; a stirring unit provided within the inner chamber and configured to stir food waste; an outer chamber positioned outside the inner chamber; and a rotation driving unit configured to rotate the stirring unit and the inner chamber, and the inner chamber and the stirring unit are rotated by the rotation driving unit in opposite directions. | 2017-09-14 |
20170260109 | METHOD FOR DIRECTLY PREPARING A FERTILIZER BY USING STRAWS AND PREPARED STRAW ORGANIC FERTILIZER - A method for preparing a fertilizer using straws and prepared straw organic fertilizer; the method includes: composting straws, spraying a compositing microbial solution containing amino acids to start decomposition of straws, and adjusting humidity of a straw compost, times of spraying a solution of product nutrients, component of the solution to obtain an up-to-standard commercial straw organic fertilizer; and keeping the composting temperature about 70° C. for long time by adjusting the turning time of the straw compost and collocation time of spraying the solution. The method is based on rich organic matters and nutrients in straws, and need for organic fertilization by soil and the like, and by improving the nutrition condition and growing condition of microorganisms of the straw compost, crop straws are directly prepared into high-quality commercial organic fertilizer in short time, so crop straws are completely utilized, and high-quality commercial organic fertilizer product is provided for fertilization. | 2017-09-14 |
20170260110 | COMPOSTING DEVICE SLIDING LID WITH A SEAL ASSEMBLY - The disclosure relates to a composting device including a housing defining an interior with an access opening providing access to the interior, a composter bin located within the interior and in communication with the access opening, and a cover slidably mounted to the housing and slidable along a sliding path between opened and closed conditions to selectively open and close the access opening. An angled seal assembly is provided on the cover and housing. Both a sealing surface and a seal are angled relative to a sliding path such that the space between the seal and the sealing surface decreases as the cover is slid from the opened to the closed condition. | 2017-09-14 |
20170260111 | METHOD AND APPARATUS FOR OPERATING A COMPOSTER DEVICE - A method and apparatus for operating a composter device includes a compost container, a condensate reservoir, a first fluid pathway fluidly coupling the composting chamber and the condensate reservoir, and a fan moving air from the composting chamber to the condensate reservoir along the first fluid pathway to define a first airflow. | 2017-09-14 |
20170260112 | METHOD FOR PRODUCING BUTADIENE AND DEVICE FOR PRODUCING BUTADIENE - A method for producing butadiene, the method including: a first synthesis step of bringing a mixed gas containing hydrogen and carbon monoxide into contact with a first catalyst to obtain a primary product containing ethanol as an intermediate; and a second synthesis step of bringing the primary product into contact with a second catalyst to obtain butadiene. | 2017-09-14 |
20170260113 | PROCESS FOR PREPARING ETHENE - The present invention provides a process for the preparation of ethene by vapour phase chemical dehydration of a feed-stream comprising ethanol and optionally water and/or ethoxy ethane, said process comprising contacting a dried supported heteropolyacid catalyst in a reactor with the feed-stream having a feed temperature of at least 200° C.; wherein before the supported heteropolyacid catalyst is contacted with the feed-stream having a feed temperature of at least 200° C., the process is initiated by: (i) drying a supported heteropolyacid catalyst in a reactor under a stream of inert gas having a feed temperature of from above 100° C. to 200° C.; and (ii) contacting the dried supported heteropolyacid catalyst with an ethanol-containing vapour stream having a feed temperature of from above 100° C. to 160° C. | 2017-09-14 |
20170260114 | ETHYLENE-TO-LIQUIDS SYSTEMS AND METHODS - Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products. | 2017-09-14 |
20170260115 | METHOD FOR PRODUCING CIS- AND TRANS-ENRICHED MDACH - A process for preparing trans-enriched MDACH, including: distilling an MDACH starting mixture in the presence of an auxiliary, which is an organic compound having a molar mass of 62 to 500 g/mol, a boiling point at least 5° C. above the boiling point of cis,cis-2,6-diamino-1-methylcyclohexane, and 2 to 4 functional groups, each of which is independently an alcohol group or a primary, secondary or tertiary amino group. The MDACH starting mixture includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, based on the total amount of MDACH present in the MDACH starting mixture. The MDACH starting mixture includes both trans and cis isomers. Trans-enriched MDACH includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, where the proportion of trans isomers in the mixture is higher than the proportion of trans isomers in the MDACH starting mixture. | 2017-09-14 |
20170260116 | METHODS OF MAKING HALOGENATED FLUORINATED ETHER-CONTAINING COMPOUNDS - Described herein are three methods for making halogenated fluorinated ether-containing compounds using a fluorinated olefin or hexafluoropropylene oxide. | 2017-09-14 |
20170260117 | Method of Making Vitamin K1 - This invention discloses a method of making vitamin K1. The mentioned method of making vitamin K1 comprises performing a first one-pot synthesis with base catalyst, performing a first hydrolysis, performing a substitution, and performing a second one-pot synthesis without metal oxidant. The starting material of this invention is stable 2-methyl-1,4-naphthoquinone. Preferably, this invention provides a method of making vitamin K1 efficiently on simplifying the operation and decreasing the side-product. More preferably, without metal residue, the vitamin K1 of this invention is without metal residue and more safety for clinical application. | 2017-09-14 |
20170260118 | METHOD FOR RECOVERING INERT MATERIAL AND METHOD FOR PRODUCING ACRYLIC ACID USING INERT MATERIAL RECOVERED BY SAID METHOD - The present invention provides a method for allowing a used inert material that has been subjected to a reaction once, which is disposed of in the background art, to be used again as well as a brand-new one. A method of recovering an inert material of the present invention is characterized by in the fixed-bed reactor, the inert material is loaded in an inert material layer provided between a first-stage catalyst layer and a second-stage catalyst layer, the first-stage catalyst layer is loaded with a first-stage catalyst for producing acrolein from propylene, and the second-stage catalyst layer is loaded with a second-stage catalyst for producing acrylic acid from acrolein, the method comprising the steps of: extracting the inert material from the fixed-bed reactor; washing the extracted inert material; and screening the washed inert material. | 2017-09-14 |
20170260119 | Asymmetrical hydrogenation reaction of ketonic acid compound - The present invention relates to the technical field of organic chemistry, specifically an asymmetrical hydrogenation of an ∂-ketonic acid compound, the technical proposal being as shown by the following formula: | 2017-09-14 |
20170260120 | METHOD FOR PRODUCING ACETIC ACID - A method for producing acetic acid includes subjecting an acetic acid solution to an acetic anhydride decreasing treatment. The acetic acid solution is present typically in, or downstream from, a distillation column ( | 2017-09-14 |
20170260121 | COMPOUND, PROCESS FOR PREPARING A COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND AND METHOD FOR TREATING CANCER - The present invention provides a compound of perillic acid in the form of a salt, having Formula II, exhibiting anti-cancer activity, where counterion M | 2017-09-14 |
20170260122 | a-ASARY-LALDEHYDE ESTER, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF - The present invention relates to α-asary-laldehyde ester, a preparation method therefor, and an application thereof. The chemical structure of the related α-asary-laldehyde ester is represented by formula I. A related application is an application of the compound in preparation of drugs for calming, mind tranquillizing, senile dementia resisting, convulsion resisting, epilepsy resisting and depression resisting. | 2017-09-14 |
20170260123 | DIALKYL CARBONATES OF BRANCHED ALCOHOLS AND THEIR USE - The disclosure relates to dialkyl carbonates of branched alcohols and their use in cosmetic and/or pharmaceutical compositions. The disclosure more particularly relates to dialkyl carbonates in which the alkyl groups are both 2-propyl-1-heptyl groups. | 2017-09-14 |
20170260124 | NO- AND H2S- RELEASING COMPOUNDS - This disclosure relates to compounds containing both an NO-releasing moiety and an H | 2017-09-14 |
20170260125 | ORGANIC-INORGANIC HYBRID COMPOUND, AMINE HYDROGEN IODIDE SALT, COMPOSITION FOR PHOTOELECTRIC CONVERSION ELEMENT, AND PHOTOELECTRIC CONVERSION ELEMENT - The present invention provides a novel compound to be used in a solar cell. The compound of the present invention is an organic-inorganic hybrid compound represented by Formula (I). | 2017-09-14 |
20170260126 | SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION - The present invention relates to compounds that modify low density lipoprotein receptor (LDLR) expression. The compounds have the structural formula I shown below: | 2017-09-14 |
20170260127 | AQUEOUS SOLUTION CONTAINING BIS(N EPSILON LAUROYLLYSINE)DICARBOXYLIC ACID DIAMIDE AND/OR SALT THEREOF, AND METHOD FOR PRODUCING SAME - The present invention provides a method of producing an aqueous solution containing bis(N | 2017-09-14 |
20170260128 | Water Soluble Haloanilide Calcium-Release Calcium Channel Inhibitory Compounds and Methods to Control Bone Erosion and Inflammation Associated with Arthritides - A compound that is selected from the group consisting of 3-(3,4-dichloroanilino)-3-oxopropanoic acid (hereinafter “DCOPA”); N-methyl-DCOPA; N,2-dimethyl-DCOPA; 2-methyl-DCOPA; isobutyl-DCOPA; N-methyl-isobutyl DCOPA; 3-(3,4-bibromoanilino)-3-oxopropanoic acid; and analogs of DCOPA; and analogs of 3-(3,4-bibromoanilino)-3-oxopropanoic acid; and pharmaceutically acceptable salts of these compounds, are disclosed. A method of controlling bone erosion in a patient comprising administering to the patient a therapeutically effective amount of at least one of these compounds, or a pharmaceutically acceptable salt of at least one of these compounds, is provided. A method of reducing inflammation in a patient having an inflammatory condition comprising administering to the patient a therapeutically effective amount of at least one of these compounds, or a pharmaceutically acceptable salt of at least one of these compounds is provided. | 2017-09-14 |
20170260129 | TRISAMIDE COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME - Provided are trisamide compounds and compositions containing the same. In an embodiment, the trisamides are represented by the following formula: | 2017-09-14 |
20170260130 | Benzimidazole Inhibitors of the Sodium Channel - The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions. | 2017-09-14 |
20170260131 | PRODRUGS OF PHENOLIC TRPV1 AGONISTS - Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity. | 2017-09-14 |
20170260132 | OXIME SULFONATE DERIVATIVES - Oxime sulfonate compounds of the formula (I), wherein R | 2017-09-14 |
20170260133 | MALASSEZIN AND ANALOGS THEREOF AS SKIN BRIGHTENING AGENTS - The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a | 2017-09-14 |
20170260134 | Ceramide Analogs - Ceramide analogs and methods of their use are provided. | 2017-09-14 |
20170260135 | PROCESS FOR LARGE SCALE PRODUCTION OF N-[4-(1-CYCLOBUTYL PIPERIDIN-4-YLOXY) PHENYL]-2-(MORPHOLIN-4-YL) ACETAMIDE DIHYDROCHLORIDE - The present, invention relates to a process for large scale production of N-[4-(1-Cyclobutyl piperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide dihydrochloride of formula (I). | 2017-09-14 |
20170260136 | HETEROARYL OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to heteroaryl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved. | 2017-09-14 |
20170260137 | MODIFIED AMINO ACIDS - Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids. The polypeptides, antibodies and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis. | 2017-09-14 |
20170260138 | PROCESS FOR PRODUCING DIAMINE DERIVATIVE - The present invention provides a low-toxic and high-recovery industrial process for synthesizing an optically active diamine derivative represented by formula (D), the process comprising the steps of: (a) mixing a compound represented by formula (A) and a compound represented by formula (C) in organic solvents and secondary amine; (b) reaction under heating; (c) cooling and adding water to the mixed solution, allowing it to crystallize to obtain the compound represented by formula (D). | 2017-09-14 |
20170260139 | NOVEL 5-AMINOTETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS AND THEIR USE - The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders. | 2017-09-14 |
20170260140 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS - The present application relates to novel substituted N,2-diarylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and/or inflammatory disorders. | 2017-09-14 |
20170260142 | SOLID FORMS OF FUNGICIDAL PYRAZOLES - Disclosed are solid forms of 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine (Compound 1). Methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another are disclosed. | 2017-09-14 |
20170260143 | NOVEL COMPOUNDS - There is provided a compound of formula (I): | 2017-09-14 |
20170260144 | METHODS FOR THE SAFE ADMINISTRATION OF IMIDAZOLE OR IMIDAZOLIUM COMPOUNDS - Methods for the safe administration of imidazole or imidazolium compounds such as zoledronic acid, and conditions that may be treated by these methods, are described herein. | 2017-09-14 |
20170260145 | HETEROCYCLIC KINASE INHIBITORS - The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1. | 2017-09-14 |
20170260146 | A CONVERGENT APPROACH TO THE TOTAL SYNTHESIS OF TELMISARTAN VIA A SUZUKI CROSS-COUPLING REACTION - Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided. | 2017-09-14 |
20170260147 | ANTIVIRAL COMPOUNDS AND METHODS - The invention relates to compounds having antiviral and methods utilizing the compounds to treat viral infections. | 2017-09-14 |
20170260148 | METHOD FOR PREPARING CALCOBUTROL - Disclosed is a novel method of preparing highly pure calcobutrol using an intermediate (butrol) of gadobutrol without using highly pure gadobutrol. This method is capable of obtaining calcobutrol at high purity and high yield through a simple and environmentally friendly process, and thus can be easily applied to mass production. | 2017-09-14 |
20170260149 | A Process for Preparing Olodaterol and Intermediates Thereof - The present invention relates to a process for preparing olodaterol and intermediates thereof. The process comprises of forming compound of Formula 1 by reacting compound of Formula 2 or its acid salt with compound of Formula 3 in the presence of an organic solvent to obtain compound of Formula 4. Protecting groups are removed from compound of Formula 4 in the presence of a suitable solvent to form compound of Formula 1. | 2017-09-14 |
20170260150 | POLYMERIZABLE COMPOUND, COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, LIQUID CRYSTAL DISPLAY ELEMENT, AND ORGANIC EL DEVICE - It is an object of the present invention to provide a polymerizable compound having a good liquid crystal property, a good alignment property, sufficient solubility in solvents, high preservation stability in a solution state, and high optical stability; a composition including the polymerizable compound; a polymer produced by polymerizing the polymerizable compound, such as a resin produced using the polymerizable compound; an optically anisotropic body including the polymer; and a liquid crystal display element and an organic EL device that include the optically anisotropic body. As a result of conducting intensive studies in order to achieve the above object, the compound represented by General Formula (I) is developed. | 2017-09-14 |
20170260151 | Novel Selenazolidine and Thiazolidine Compounds for Treating Cancer and Other Diseases - The present invention includes compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention. | 2017-09-14 |
20170260152 | 2-(2,3-EPOXYPROPYL)PHENOL COMPOSITION AND METHOD OF MAKING - Disclosed herein is a method of making a 2-(2,3-epoxypropyl)phenol by reacting a 2-allylphenol with an oxidant in the presence of a catalyst. A 3-chromanol can be formed as a by-product. The method can be used to make 2-(2,3-epoxypropyl)-6-methylphenol. Transition metal catalysts and peroxide oxidants can be used. Also disclosed is a composition comprising 1 to 90 weight percent of a 2-(2,3-epoxypropylphenol, 5 to 90 weight percent of a 2-allylphenol, and 0 to 40 weight percent of a 3-chromanol, and in particular, a composition comprising 1 to 90 weight percent 2-(2,3-epoxypropyl)-6-methylphenol, 5 to 90 weight percent 2-allyl-6-methylphenol, and 0 to 40 weight percent 8-methyl-3-chromanol. | 2017-09-14 |
20170260153 | Use of Reactants in the Production of 2,5-Furandicarboxylic Acid - Methods for providing effective, efficient and convenient ways of producing 2,5-furandicarboxylic acid are presented. In addition, compositions of 2,5-furandicarboxylic acid including 2,5-furandicarboxylic acid and at least one byproduct are presented. In some aspects, 4-deoxy-5-dehydroglucaric acid is dehydrated to obtain the 2,5-furandicarboxylic acid. A solvent, catalyst, and/or reactant may be combined with the 4-deoxy-5-dehydroglucaric acid to produce a reaction product including the 2,5-furandicarboxylic acid. In some arrangements, the reaction product may additionally include water and/or byproducts. | 2017-09-14 |
20170260154 | OXIDATION PROCESS TO PRODUCE A PURIFIED CARBOXYLIC ACID PRODUCT VIA SOLVENT DISPLACEMENT AND POST OXIDATION - Disclosed is a process to produce a dry purified carboxylic acid product comprising furan-2,5-dicarboxylic acid (FDCA). The process comprises oxidizing at least one oxidizable compound selected from the following group: 5-(hydroxymethyl)furfural (5-HMF), 5-HMF esters (5-R(CO)OCH | 2017-09-14 |
20170260155 | Method for Preparing Isobenzofuran-1(3H)-One Compound - A method for preparing an isobenzofuran-1(3H)-one based compound of the following formula I is provided. R1, R2 and p are defined in the specification. | 2017-09-14 |
20170260156 | HYDROGENATION OF CATMINT OIL - Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone. | 2017-09-14 |
20170260157 | PROCESS FOR PREPARATION AND PURIFICATION OF POMALIDOMIDE - Processes are disclosed for making pomalidomide which involve reducing 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione using a catalyst and at least one solvent. The process may include reacting 3-nitrophthalic anhydride with α-amino glutarimide hydrochloride to obtain the 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione. The process may further include, prior to the reducing step, subjecting the 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione to a purification process comprising heating a mixture of 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione and 1,4-dioxane to obtain a solution, treating the obtained solution with carbon, removing the carbon from the solution to obtain a purified 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione solution and using the purified 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione solution for the reducing step. Processes disclosed achieve pomalidomide having a purity of greater than 99% as measured by HPLC with no individual impurity present in an amount greater than 0.1% and total impurities comprising not more than 0.5%. | 2017-09-14 |
20170260158 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR - The present invention relates to quinoline compounds of formula I | 2017-09-14 |
20170260159 | TETRAZOLONE-SUBSTITUTED DIHYDROPYRIDINONE MGAT2 INHIBITORS - The present invention provides compounds of Formula (I): | 2017-09-14 |
20170260160 | INDOLE CARBOXAMIDE COMPOUNDS - Disclosed are compounds of Formula (I): | 2017-09-14 |
20170260161 | BI-BENZYL ISOQUINOLINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF IN HEPATOPATHY TREATMENT AND PREVENTION - The invention disclosed a compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and a prodrug, pharmaceutically acceptable salt and metabolite thereof, X | 2017-09-14 |
20170260162 | POLYMORPHIC FORMS OF NILOTINIB HYDROCHLORIDE - Crystalline Forms R5, R5 | 2017-09-14 |
20170260163 | THERAPEUTIC INHIBITORY COMPOUNDS - Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like. | 2017-09-14 |
20170260164 | CD38 INHIBITORS AND METHODS OF TREATMENT - Compounds of Formula I and methods of treating diseases of metabolism by modulating cellular NAD+ levels through the inhibition of the CD38 enzyme, are disclosed. | 2017-09-14 |
20170260165 | 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase - Imidazolyl-pyrimidine and related compounds, as can utilize heme-iron coordination in the selective inhibition of neuronal nitric oxide synthase. | 2017-09-14 |
20170260166 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS - Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I | 2017-09-14 |
20170260167 | SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3-YLVINYL)PYRIMIDINE - The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts. | 2017-09-14 |
20170260168 | 2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES - Provided herein are compounds of the general Formula I: | 2017-09-14 |
20170260169 | INHIBITORS FOR STEROID RESPONSE ELEMENTS AND RNA POLYMERASE II AND RELATED METHODS - The present invention relates to polyamides capable of inhibiting ARE-, GRE- and ERE-mediated gene regulation in cells. The present invention also relates to polyamides capable of modulating the activity of RNA polymerase II and p53. The invention also relates to methods to treat diseases related to ARE-, GRE- and ERE-mediated gene regulation and to RNA polymerase II and p53 activity. | 2017-09-14 |
20170260170 | FLAVONOID DERIVATIVE COMPOUNDS AND METHOD FOR PREPARING SAME BY DEPOLYMERIZATION OF CONDENSED TANNINS - A compound of general formula (I) in which R | 2017-09-14 |
20170260171 | ALPHA-HYDROXY-BETA-AZIDO-TETRAZOLES - Alpha-hydroxy-beta-azido tetrazole compounds of formula (I): | 2017-09-14 |
20170260172 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS - This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam with a chiral Ni catalyst, an aryl nitrile, and an aryl halide. | 2017-09-14 |
20170260173 | DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDTIONS - Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) | 2017-09-14 |
20170260174 | Benzene, Pyridine, and Pyridazine Derivatives - Disclosed are compounds and pharmaceutically acceptable salts of Formula I | 2017-09-14 |
20170260175 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE - The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. | 2017-09-14 |
20170260176 | GAMMA-DIKETONES AS WNT/BETA -CATENIN SIGNALING PATHWAY ACTIVATORS - The present disclosure provides γ-diketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases. | 2017-09-14 |
20170260177 | METHYL OXAZOLE OREXIN RECEPTOR ANTAGONISTS - The present invention is directed to methyl oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved. | 2017-09-14 |
20170260178 | ANTIBACTERIAL COMPOUNDS - The present invention provides a compound of the following formula, salts, racemates, diastereomers, enantiomers, esters, carbamates, phosphates, sulfates, deuterated forms and prodrugs thereof. Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture. | 2017-09-14 |
20170260179 | 2-(1H-INDAZOL-3-YL)-1H-IMIDAZO[4,5-C]PYRIDINE AND THERAPEUTIC USES THEREOF - Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states. | 2017-09-14 |
20170260180 | DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA - Provided are novel compounds of Formula (I): | 2017-09-14 |
20170260181 | S-IMINO-S-OXO IMINOTHIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain C-6 spirocarbocyclic iminothiadiazine compounds, including compounds Formula (I): or a tautomer thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R | 2017-09-14 |
20170260182 | PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | 2017-09-14 |
20170260183 | BICYCLIC COMPOUNDS AS PEST CONTROL AGENTS - The present application relates to novel bicyclic compounds, to compositions comprising these compounds, to their use for controlling animal pests and to processes and intermediates for their preparation. | 2017-09-14 |
20170260184 | TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS - The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides TLR7 agonists and TLR7/TLR8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof. Derivatives of the imidazoquinoline derived compounds also include dendrimers and dimers of the imidazoquinoline derived compounds, and methods of making and using the dendrimeic and dimeric imidazoquinoline derived compounds. The present disclosure also provides dual TLR2/TLR7 hybrid agonists that include imidazoquinoline derived compounds of the present disclosure. | 2017-09-14 |
20170260185 | 2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD) - The present invention provides compounds of formula (I) and in particular 2-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4.5]decan-10-one derivatives and related compounds as inhibitors of human dopamine-active-transporter (DAT) protein for the treatment of sexual dysfunction, affective disorders, anxiety, depression, chronic fatigue, Tourette syndrome, Angelman syndrome, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), obesity, pain, obsessive-compulsive disorder, movement disorders, CNS disorders, sleep disorders, narcolepsy, conduct disorder, substance abuse (including smoking cessation), eating disorders, and impulse control disorders. | 2017-09-14 |
20170260186 | PROCESS OF PREPARING AMORPHOUS FORM OF IDELALISIB - A process for preparing an amorphous form of idelalisib comprises:
| 2017-09-14 |
20170260187 | NEW AGENTS FOR TREATING NEUROGENIC INFLAMMATION AND NEUROPATHIC HYPERALGESIA RELATED DISORDERS - The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the and solvates, hydrates and pharmaceutically acceptable salts thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical N compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia. Said 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine compounds have been identified as new drug candidates for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia. | 2017-09-14 |
20170260188 | Tricyclic Compounds as Inhibitors of Immunosuppression Mediated By Tryptophan Metabolization - Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease. | 2017-09-14 |
20170260189 | METHOD OF PREPARING AZA-PYRIDONE COMPOUNDS - Disclosed herein are methods for obtaining aza-pyridone compounds, which can be useful for ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection. | 2017-09-14 |
20170260190 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE - This invention provides substituted pyrimidine compounds having the formula: | 2017-09-14 |
20170260191 | KINASE INHIBITORS AND RELATED METHODS OF USE - The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as PIM kinases. The compounds can be used in methods of treating various disorders, including cancers. | 2017-09-14 |
20170260192 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS - The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R | 2017-09-14 |
20170260193 | Crystalline Forms of Therapeutic Compounds and Uses Thereof - Described herein is certain crystalline forms of Compound 5, as well as pharmaceutical compositions employing the crystalline forms. Also provided are particles (e.g., nanoparticles) comprising such crystalline forms or pharmaceutical compositions. In certain examples, the particles are mucus penetrating particles (MPPs). The present invention further relates to methods of treating or preventing diseases using crystalline forms or pharmaceutical compositions. | 2017-09-14 |
20170260194 | CAMPTOTHECIN DERIVATIVES AND USES THEREOF - Provided herein are camptothecin derivatives and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, cancer using the compounds and pharmaceutical compositions disclosed herein. | 2017-09-14 |
20170260195 | SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS - The application relates to novel sulfoximine substituted quinazoline derivatives of formula (I) wherein Ar, R | 2017-09-14 |
20170260196 | Pseudopolymorphic Forms of a HIV Protease Inhibitor - New pseudopolymorphic forms of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate and processes for producing them are disclosed. | 2017-09-14 |
20170260197 | THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS - The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R | 2017-09-14 |
20170260198 | SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES - Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals. | 2017-09-14 |
20170260199 | OXAZEPINE COMPOUND AND AGRICULTURAL/HORTICULTURAL INSECTICIDE CONTAINING SAID COMPOUND AS ACTIVE INGREDIENT, AND METHOD FOR USING THE SAME - An oxazepine compound, or salt thereof, has General Formula (I): | 2017-09-14 |
20170260200 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS - The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent. | 2017-09-14 |
20170260201 | 5-HT3 RECEPTOR ANTAGONISTS - The present invention provides 5-HT3 receptor antagonists of Formula (I): | 2017-09-14 |
20170260202 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS - This invention provides compounds of Formula 11: | 2017-09-14 |
20170260203 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY - The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. | 2017-09-14 |
20170260204 | POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE - Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): | 2017-09-14 |
20170260205 | MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES - Macrocyclic benzodiazepine dimers having a structure represented by formula I | 2017-09-14 |
20170260206 | ANDROGEN RECEPTOR MODULATING COMPOUNDS - The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof. | 2017-09-14 |