37th week of 2014 patent applcation highlights part 54 |
Patent application number | Title | Published |
20140255865 | ORTHODONTIC APPLIANCE - An orthodontic appliance consisting of a two-component bracket assembly and a customized wire where the tooth component of the bracket assembly is semi-permanently glued to the tooth surface and the wire component of the bracket assembly is securely attached to the customized wire. The customized wire has a configuration that is derived from characteristics of both the mal-aligned and aligned states of the teeth. The series of wire components of the bracket assembly are separated by an inter-bracket distance and are specifically oriented along the customized wire to form the customized wire-bracket device. When the wire component and the tooth component of the bracket assembly are engaged, the alignment of the teeth occurs due to the elastic recoil of the customized wire. The customized wire-bracket device is completely detachable and re-attachable to the tooth component of the bracket assembly as are the two components of the bracket assembly. | 2014-09-11 |
20140255866 | Telescopic Orthodontic Appliance - An orthodontic appliance includes a telescopic assembly with an end tube and a telescopic member. A distal connector secured to the end tube at a generally distal end of the telescopic assembly. An end cap engages the distal end of the end tube. A spring is secured to the end cap and extends coaxially within the cover and the end tube. The spring is configured to impart a biasing force against the distal end of the telescopic member. | 2014-09-11 |
20140255867 | Device and System For Dental Applications and Method Relating Thereto - The present invention relates to various devices, systems, kits and methods having dental applications. For instance, a dental tray is provided for use in taking an impression of a person's teeth. A dental shade chart is also provided and includes a shade sticker for use in determining the shade of a person's tooth. Further, the dental tray and/or the shade chart can be included in a kit. | 2014-09-11 |
20140255868 | HOLDING DEVICE FOR AN INTRAORAL SCANNER - A holding device with a base element for a handpiece of an intraoral scanner, which has a head area ( | 2014-09-11 |
20140255869 | DEVICE FOR TREATING PERI-IMPLANTITIS - A device includes: a cylindrical first main body having a bottom surface, an inner side surface, and an outer side surface, the first main body having at least one electromagnetic wave irradiation port and at least one antiseptic discharge port, the at least one electromagnetic wave irradiation port being provided in the inner side surface of the first main body, the at least one antiseptic discharge port being provided in the bottom surface and/or the inner side surface of the first main body; an electromagnetic wave generation source; and an antiseptic supply source. | 2014-09-11 |
20140255870 | DENTAL AND MEDICAL SUCTION TOOLS - A suction apparatus has a tube. The tube has an end to be inserted in a user's body. The tube has another end for coupling with a vacuum hose to remove air. A check valve coupled is to the tube. The check valve is configured to prevent a back pressure flow into the user's mouth. For an embodiment, the dental suction apparatus includes a base coupled to the tube. Base includes a control valve to control the air removal. For an embodiment, the dental suction apparatus includes a check valve coupler coupled to the tube. For an embodiment, the check valve is on the check valve coupler. | 2014-09-11 |
20140255871 | DYNAMOELECTRIC CONVERTER AND MEDICAL OR DENTAL DEVICE HAVING A DYNAMOELECTRIC CONVERTER - Fluid-operated dynamoelectric converters for medical or dental devices are described. The dynamoelectric converters have: a fluid line which is designed in one piece with an outer sleeve of the dynamoelectric converter and protrudes at its end which faces away from the dynamoelectric converter beyond a connecting end of the medical or dental device; a fluid-operated impeller which is designed in one piece with a rotor sleeve receiving the magnetic element; a one-piece, sleeve-shaped magnetic return element which surrounds the rotor and the electric winding of the stator and has a magnetically conductive material. | 2014-09-11 |
20140255872 | DENTAL IMPLANT WITH ANGLED HEAD AND BENDING ZONE - A dental implant includes an enossal implant body, a head, and a neck or bending zone and a prosthetic platform or an abutment equator, and at least one rotation securing engagement surface or parts thereof that come to rest underneath the prosthetic platform or the abutment equator. The implant head may be mounted at an angle to a longitudinal axis of the enossal implant body. | 2014-09-11 |
20140255873 | Simplified Protocol for Fixed Implant Restorations Using Intra-Oral Scanning and Dental CAD/CAM - A method of creating implant-supported dentures without physical impressions is provided. Digital impressions may be obtained from scanning the oral cavity, its structures, landmarks, and implant positions. These scans together provide a highly accurate, digital model from which a digital patient model may be designed. Digital denture designs may be reproduced as denture shapes by automated manufacturing processes, and an implant-supported denture may be manufactured therefrom. Methods form making a try-in denture and a final implant-supported denture are provided. | 2014-09-11 |
20140255874 | METHOD OF MANUFACTURING A FUNCTIONALIZED IMPLANT, AND FUNCTIONALIZED IMPLANT - A method of manufacturing a functionalized implant, in particular a dental implant, is provided, including first providing a substrate for the implant and applying a highly porous, hydrophilic coating which contains at least one of the following materials for functionalization: zirconium or titanium or zirconium alloy or titanium alloy, zirconium oxide or titanium oxide, calcium phosphate, calcium titanate or calcium zirconate. Further provision is made for a functionalized implant, in particular a dental implant. | 2014-09-11 |
20140255875 | METHOD AND DEVICE FOR THE PRODUCTION OF A DENTAL PROSTHESIS PART - The method for the production of a dental prosthesis part comprises the provision ( | 2014-09-11 |
20140255876 | Systems and Methods for Analyzing Dynamic Dental Occlusions and Making Dental Appliances - Systems and methods for analyzing dynamic occlusion during replicated excursions of virtual three-dimensional representations of a dental patient's occlusal complex are provided. The method may include scanning a patient's jaws and teeth configuration using a medical imaging system such as CBCT, laser scanners, or traditional dental impressions; creating a virtual three-dimensional representation of the patient's occlusal complex; replicating excursions of the virtual three-dimensional representation of the patient's occlusal complex based at least on virtual inter-condylar angles and distances; determining acceptable occlusal contacts and/or malocclusions within the virtual three-dimensional representation of the patient's occlusal complex based at least in part on virtual dynamic occlusion during the replicated excursions, and determining at least one virtual dental appliance and/or orthodontic repositioning of one or more teeth based at least in part on the one or more acceptable occlusal contacts and/or malocclusions within the virtual three-dimensional representation of the patient's occlusal complex. | 2014-09-11 |
20140255877 | IMPRESSION DEVICE AND METHOD FOR THREE-DIMENSIONAL ACQUISITION OF INTRAORAL STRUCTURES, AND CORRESPONDING SCANNING DEVICE - The invention relates to an impression device and a method for three-dimensional acquisition of intraoral structures as well as a corresponding scanning device. The impression device of the invention comprises an impression sleeve, which has an open and a closed end, and at least one marker which is three-dimensional and disposed on the outside of the impression sleeve. | 2014-09-11 |
20140255878 | METHOD FOR OPTICAL ACQUISITION OF THE THREE-DIMENSIONAL GEOMETRY OF OBJECTS - In the case of a method for optical acquisition of the three-dimensional geometry of objects, in particular teeth ( | 2014-09-11 |
20140255879 | FLIGHT-ICING SIMULATOR - This invention supplies a flight-icing simulator to train the pilots with skills under flight-icing conditions. This simulator is composed of several modules to provide pilots the information of ice distribution and strength on aircrafts, the distance of the aircraft to the icing dangerous zone, the perturbation of the points with feedback function, etc. | 2014-09-11 |
20140255880 | TACTILE GRAPHIC DISPLAY - A tactile graphic display for providing a display representation of a graph or image generated by a graphic device for visually impaired users or other users who wish to access tactile information. The tactile graphic display includes a control and interface module in communication with a dot matrix, which is associated with pin nut assemblies including caps that serve as dots in the dot matrix. The control and interface module provides motor drive signals that raise selected dots above the top surface of a top panel to form the dot matrix display. Proximity sensors in or associated with the top panel sense touching of one or more dots and/or proximate presence of a finger or hand near the top surface of the top panel. The proximity sensors provide dot matrix engagement signals to the control and interface module for processing. | 2014-09-11 |
20140255881 | METHOD AND APPARATUS FOR TRAINING A USER OF A SOFTWARE APPLICATION - A method that incorporates teachings of the subject disclosure may include, for example, detecting a game stimulus signal generated by a first gaming accessory device, determining a first game action result based on the game stimulus signal, analyzing the first game action result to provide a first coaching message to achieve a desired result, and presenting the coaching message. Additional embodiments are disclosed. | 2014-09-11 |
20140255882 | INTERACTIVE ENGINE TO PROVIDE PERSONAL RECOMMENDATIONS FOR NUTRITION, TO HELP THE GENERAL PUBLIC TO LIVE A BALANCED HEALTHIER LIFESTYLE - An algorithm and method to provide personal recommendations for nutrition based on preferences, habits, medical and activity profiles for users, and constraints. The algorithm can also be fed and takes into account real-time feedback from the user. The method allows creating a personal nutritional schedule based on a set of constraints, which are solved using an optimization algorithm to find the diet best fitting each user. The method also includes analyzing a single user by applying various statistical techniques, enabling the algorithm to infer the user's preferences and updating of the constraints, analyzing and clustering of the general user population based on statistical principles, giving the algorithm insightful information and allowing improved performance by means of “machine-learning,” and creating a list of recommended food items/recipes to help users live a balanced, healthier lifestyle. | 2014-09-11 |
20140255883 | SYSTEM AND METHOD FOR AUTOMATED MONITORING OF FOOD AND BEVERAGE INTAKE, DETERMINING ASSOCIATED NUTRITIONAL INFORMATION AND COMPARING WITH A PREDETERMINED DIETARY PLAN - A system for automated monitoring of food and beverage intake comprises a weighing assembly including a scale, a product identifier adapted to identify product IDs and a data transfer module in communication with the scale and product identifier. The data transfer module being adapted to receive product IDs associated with food and beverages use information including any change in weight of the food and beverage. The system also comprises a food and beverage inventory database, a food nutrient database, a dietary intake plan for a user of said system; a dietary intake recorder, and a user interface in communication with said dietary intake recorder. The dietary intake recorder is automatically updated with food and beverage use information identified by the weighing assembly. The user interface is also adapted to facilitate input of external food and beverage intake of a user to the dietary intake recorder. | 2014-09-11 |
20140255884 | INCREMENTALLY-SIZED STANDARD-SIZED EATING-WARE SYSTEM FOR WEIGHT MANAGEMENT - A diet management system, including a plurality of different-sized templates, each template having the same shape and defining a size of a food portion in accordance with a standardized eating system. Each template is collapsible for storage and/or transportation, and each template includes an indicia demarking the correspondence of the template with the standardized eating system. | 2014-09-11 |
20140255885 | Language Study System and Method Employing Multifaceted Block Device Representation System - A composition in the target language is parsed into plural different linguistic components, including sound level, grammar level and at least one functional grammar level component. The linguistic components are then expressed on different facets of an n-sided block device representation system according to predefined sets of rules. The facets of the block device may then be selectively examined by the learner to visualize how the target language functions to express the composition with respect to the way sounds, grammar and functional grammar are used. The block device representation system may be computer-implemented, rendering the facets on display panels associated with physical blocks, or as computer-generated images upon a display device. | 2014-09-11 |
20140255886 | Systems and Methods for Content Scoring of Spoken Responses - Computer-implemented systems and methods are provided for automatically scoring the content of moderately predictable responses. For example, a computer performing the content scoring analysis can receive a response (either in text or spoken form) to a prompt. The computer can determine the content correctness of the response by analyzing one or more content features. One of the content features is analyzed by applying one or more regular expressions, determined based on training responses associated with the prompt. Another content feature is analyzed by applying one or more context free grammars, determined based on training responses associated with the prompt. Another content feature is analyzed by applying a keyword list, determined based on the test prompt eliciting the response and/or stimulus material. Another content feature is analyzed by applying one or more probabilistic n-gram models, determined based on training responses associated with the prompt. Another content feature is analyzed by comparing a POS response vector, determined based on the response, to one or more POS training vectors, determined based on training responses associated with the prompt. Another content feature is analyzed by comparing a response n-gram count to one or more training n-gram counts using an n-gram matching evaluation metric (e.g., BLEU). Another content feature is analyzed by comparing the response to one to training responses associated with the prompt using a dissimilarity metric (e.g., edit distance and word error rate). | 2014-09-11 |
20140255887 | SYSTEM AND METHOD FOR EXPRESSIVE LANGUAGE, DEVELOPMENTAL DISORDER, AND EMOTION ASSESSMENT - In one embodiment, a method for detecting autism in a natural language environment using a microphone, sound recorder, and a computer programmed with software for the specialized purpose of processing recordings captured by the microphone and sound recorder combination, the computer programmed to execute the method, includes segmenting an audio signal captured by the microphone and sound recorder combination using the computer programmed for the specialized purpose into a plurality recording segments. The method further includes determining which of the plurality of recording segments correspond to a key child. The method further includes determining which of the plurality of recording segments that correspond to the key child are classified as key child recordings. Additionally, the method includes extracting phone-based features of the key child recordings; comparing the phone-based features of the key child recordings to known phone-based features for children; and determining a likelihood of autism based on the comparing. | 2014-09-11 |
20140255888 | Optical neuroinformatics - A method is provided for improving cognitive performance assessment in a smooth pursuit cognitive performance test by using measurement metrics including a lead/lag metric, a radial inbounding metric, a path dependent velocity metric, a path drift metric, a velocity variability metric, or a variance statistics metric. | 2014-09-11 |
20140255889 | SYSTEM AND METHOD FOR A COMPREHENSIVE INTEGRATED EDUCATION SYSTEM - A gateway system for providing a comprehensive integrated education system. It is implemented through a cloud-computing platform, linking together learning and assessment systems, which provide learning, education, and evaluation services for a user, and reward systems, which provide rewards for a user for successfully completing learning and education processes, which are connected to the cloud-computing platform. In some embodiments, a user is a student, and a desired reward is access to certain features on the student's electronic computing device. The gateway system ensures that the student correctly answers certain test questions which have been appropriately chosen before unlocking those features. | 2014-09-11 |
20140255890 | PATIENT SUPPORT APPARATUS WITH PHYSICAL THERAPY SYSTEM - A patient support apparatus configured to enable an occupant of the patient support apparatus to perform a physical therapy routine while being supported by the patient support apparatus. | 2014-09-11 |
20140255891 | SKATE TRAINER - An apparatus for improving ice skating technique comprises a body formed of at least one block having first and second sides and first and second elastic loops operably connected to and formed adjacent to each of the first and second sides of the body. Each loop is sized to receive the knee of a user therein so as to locate the body therebetween. The elastic loops may be formed of a continuous member passed through a bore in a plurality of bodies | 2014-09-11 |
20140255892 | DEVICE AND METHOD FOR TAPERING MEDICATIONS IN POST-OPERATIVE PATIENTS - A device and method of tapering medication in a post-operative patient is provided. The system includes a stationary base having indicia thereon representative of a defined period of time; a first circular wheel concentrically positioned on the stationary base, the first circular wheel representative of a first medication being taken by a patient; and a pin coupling the substantially circular wheel to said stationary base to permit the wheel to rotate 360 degrees about said base. The method of tapering medication includes gradually increasing the time intervals that medication is administered to a post-operative patient. | 2014-09-11 |
20140255893 | METHOD AND SYSTEM FOR MANAGING SKILLS ASSESSMENT - The present invention is directed to a method and skills assessment tool for managing a testing session in a clinical skills testing center comprising a plurality of assessment stations. The method according to the preferred embodiment of the present invention includes configuring the plurality of assessment stations by associating each of the stations with a case type prior to the beginning of the testing session, receiving electronic identification of a student at one of a plurality of assessment stations prior to the student commencing an encounter at the one assessment station during the testing session, and, in response to receiving the student's identification, automatically assigning the student to the one assessment station for the encounter, where the encounter corresponds with the case type associated with the one assessment station. | 2014-09-11 |
20140255894 | Inflatable Exhibit of a Human Heart and Method - An inflatable exhibit of a heart includes an inflatable infrastructure inflatable to a three-dimensional partial representation of the heart at a scale greater than at least, 10:1, but more preferably greater than 20:1, and most preferably, greater than 25:1. The infrastructure includes a cross-sectional plane thereacross. The exhibit further includes a walk-through passageway defined, at least, in part by the inflated infrastructure, and extending through the inflated infrastructure. The cross-sectional plane defines a plane of the passageway. | 2014-09-11 |
20140255895 | SYSTEM AND METHOD FOR TRAINING AGENTS OF A CONTACT CENTER - A training system for providing training to agents of an enterprise is provided. The training system may include a retrieval module for retrieving content from at least one predetermined resource. The training system further may include a topic determining module for determining at least one topic based on the retrieved content. The training system further may include an answer selecting module for selecting an answer for the at least one topic from the retrieved content based upon predefined rules. The training system further may include a reporting module for reporting the at least one topic and answer to one or more agents of the enterprise. | 2014-09-11 |
20140255896 | AUTOMATED TESTING AND IMPROVEMENT OF TEACHING APPROACHES - Techniques are provided for testing alternative teaching approaches for specific portions of a curriculum. Test-triggering rules are established, each of which corresponds to a specific target-area. Each test-triggering rule specifies conditions which, if satisfied, indicate that a new teaching approach should be tested for the test-triggering rule's target-area. Once the test-triggering rules are established, the assessment results produced by students in instances of courses that implement the curriculum are monitored. If the assessment results satisfy the conditions, a revised teaching approach is selected for the target-area. The revision is then pushed out in waves where some course takers see the revision and others are held constant (A/B analysis). If a hypothesis is validated, then the appropriate revision can be permanently adopted. | 2014-09-11 |
20140255897 | Learning Management System - Disclosed is a “learning and doing” process-oriented learning management system designed to incorporate learning into collaborative work processes by managing work processes for users to submit, review, and approve work products; provide just-in-time access to learning resources for workers to learn how to complete the work products that are intended to result from the collaborative work process; and update the work process where worker/learners collaborate to create/update, review, and approve the learning resources. The learning management system can also manage a large number of collaborative work processes and integrates learning, training, and education on a single platform. In addition, it provides the capability to embed help for using the software into the work processes that the software manages. | 2014-09-11 |
20140255898 | Assessing Reading Comprehension And Critical Thinking Using Annotation Objects - A competency assessment system enables reading comprehension and critical thinking skills of a knowledge worker to be assessed. The competency assessment system enables a knowledge worker to create an assertion map based on one or more source literals. The assertion map comprises several assertion objects that link to different portions of the source literals or other assertion objects. The competency assessment system compares the assertion map created by the knowledge worker with another assertion map to assess the worker's reading comprehension and critical thinking skills. | 2014-09-11 |
20140255899 | COMMUNICATION TABLET FOR TEACHING - A teaching device formed by the combination of a wireless communication terminal located in a classroom of an educational establishment and a set of communication tablets that each belong to a student or a teacher of the class. The tablet has two rigid flaps that are articulated about a hinge which is hollow in order to store a stylus therein and is able to rotate through 360°. Each of the two flaps has an impact- and liquid-resistant outer face and an impact-and liquid-resistant inner face and a screen for reading and writing manually by means of a stylus. | 2014-09-11 |
20140255900 | DUAL TASK MENTAL DEFICIENCY ASSESSMENT SYSTEMS AND METHODS - Systems and methods for simultaneously conducting a non-reflex motor test and a cognitive test are described herein. This dual-test methodology compares a baseline performance for an individual to a diagnostic performance for the individual to determine whether an individual has suffered a concussion or other mental deficiency. The baseline performance data is collected before a suspected injury, and the diagnostic performance data is collected after the suspected injury. The methodology may also be used to determine how an individual is recovering from a concussion or mental deficiency by comparing later performances to earlier performances. | 2014-09-11 |
20140255901 | Apparatus, System, and Method for Displaying Content - An apparatus, system, and method for displaying content. A portion of content may be displayed to a user. Personal and community data relating to the portion of content may be displayed alongside the portion of content. The personal and community data may include performance-related data. Furthermore, portions of content may be selectively displayed based on customizable performance thresholds. | 2014-09-11 |
20140255902 | DISPLAY BOARD ASSEMBLY - A display board assembly includes a display board having a planar surface and an edge extending along at least a portion of the planar surface. The display board assembly also includes a mounting member coupled to the display board. The mounting member defines a first gap adjacent the planar surface of the display board and a second gap adjacent the edge of the display board. The display board assembly further includes a display board accessory including a projection. The display board accessory is removably coupled to the mounting member in one of a first position, in which the projection is received in the first gap, and a second position, in which the projection is received in the second gap. | 2014-09-11 |
20140255903 | DURABLE GLASS ARTICLES FOR USE AS WRITABLE ERASABLE MARKER BOARDS - The invention relates to glass articles suitable for use as writable erasable marker boards. More particularly, disclosed is a strengthened glass article suitable for use as a writable erasable marker boards, wherein the glass sheet exhibits an ion exchanged glass having a front surface and a back surface and exhibiting a thickness of less than 2.0 mm and having a depth of layer (DOL) greater than 20 microns and a surface compressive strength of at least 300 MPa. The strengthened glass article exhibits certain optical properties which render it particularly suitable for use as a writable erasable marker boards electronic including: (1) shadow parallax to thickness ratio of less than 1 measured at a 60 degree incident light angle and for an index of refraction n; and, (2) a haze of less than 50%. Further disclosed is a markerboard with improved magnetic force attributes; sufficient to hold weak magnets in place. | 2014-09-11 |
20140255904 | Modulating ischemic injury and preserving/storing tissue - The invention is directed to methods of modulating ischemic injury in tissues and organs, including donor tissue and organs and intact tissue and organs. The invention is further directed to methods of increasing time to ischemic injury in such tissues and organs. The invention is further directed to storing and preserving donor tissues and organs. Such methods utilize compositions comprising Amnion-derived Cellular Cytokine Solution (herein referred to as ACCS). The ACCS compositions may be formulated for sustained-release, targeted-release, timed-release, extended-release, etc. and may be used alone or in combination with various suitable active agents. | 2014-09-11 |
20140255905 | MEDICAL FLUID COMPRISING GLOBULIN AND ITS USE FOR PRESERVATION OF HARVESTED ORGANS - A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and/or preservation. The fluid comprise oncotic agents, comprising albumin, a dextran compound and at least one globulin. The globulin has a concentration, which is larger than physiological concentration thereof. In addition, the fluid comprises hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. Moreover, the medical fluid comprises an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. Moreover, cocaine, adrenalin, and/or noradrenalin, may be present in concentrations of each about 1 nM to 100 nM, for example in a ratio of 1:1:1. | 2014-09-11 |
20140255906 | ELECTROMAGNETIC BLOOD PRESERVATION AND STORAGE - A method and apparatus for storing RBC wherein electromagnetic stimulation such as applying an electrical current or magnetic field to the stored blood extends the viability or shelf life of the stored RBC. | 2014-09-11 |
20140255907 | UNIQUE BUFFERING SYSTEM FOR CELL CULTURE MEDIA AND GAMETE AND EMBRYO CULTURE MEDIA AND METHODS - The invention relates to compositions and methods for continuous stabilization of pH of cell culture medium notwithstanding change from one distinct environment to another environment. The methods include providing a buffering system that includes a sodium bicarbonate buffer and at least two zwitterionic buffers having concentrations significantly reduced as compared to conventionally used media buffers utilizing a single zwitterionic buffer. | 2014-09-11 |
20140255908 | APPARATUS, SYSTEMS, AND METHODS FOR PROCESSING PLATELETS AND CONTAMINATED BLOOD - One aspect of the present disclosure relates to a bag for storing platelets or contaminated blood previously withdrawn from a subject. The bag can comprise a flexible, closed container and at least one removable heat transfer member adhered to an outer surface portion of the container. The container can include an inlet therein that forms part of the container. The inlet can be adapted for fluid-tight connection to a tube member through which the platelets or contaminated blood are caused to flow. | 2014-09-11 |
20140255909 | APPARATUS, SYSTEMS, AND METHODS FOR MINIMIZING HEMOLYSIS - One aspect of the present disclosure relates to a bag for storing blood previously withdrawn from a subject. The bag can comprise a flexible, closed container and at least one removable heat transfer member adhered to an outer surface portion of the container. The container can include an inlet therein that forms part of the container. The inlet can be adapted for fluid-tight connection to a tube member through which the blood is caused to flow. | 2014-09-11 |
20140255910 | METHOD FOR CONTROLLED OPERATION OF A BIOTECHNOLOGICAL APPARATUS AND BIOREACTOR SYSTEM - A method for controlling electrical power consumption for a first group of functional which can be used for operational management during operation of the bioreactor components during operation comprises, inter alia, adjusting a present power control signal for one or more of the functional components from the first group in order to optimise power consumption, when a comparison shows for the first group of functional components that the currently required total electrical power consumption is greater than a predefined total electrical power consumption, such that, for the first group of functional components, an adjusted total electrical power consumption is not greater than the predefined total electrical power consumption. A biotechnological apparatus comprises a bioreactor, a reactor vessel formed in the bioreactor and having a cultivation chamber, and a temperature control device provided with a heat pump and configured to control the temperature of the cultivation chamber. | 2014-09-11 |
20140255911 | SAMPLE DETECTION APPARATUS AND DETECTION METHOD - According to one embodiment, a sample detection apparatus including an insulating partition to divide a first and a second region, a pore formed in the partition, a first electrode arranged in the first region, a second electrode arranged in the second region, a power source configured to apply electrical current between the first and second electrode in a state in which a reagent containing a capture substance to be bound to a target and a tag particle bound to the capture substance is introduced into the first region together with a sample, and an electrolyte solution is introduced into the second region, a measurement unit configured to observe a change in a conductive state, and a detection unit to detect presence/absence of the target in the sample based on an observation result. | 2014-09-11 |
20140255912 | Sample Collection and Analysis - Management of the health status of an animal colony using a plurality of blood collection cards and the analysis of dried blood from members of the colony that has been collected on the cards. Members of the colony may be removed from the colony as a result of the analysis. | 2014-09-11 |
20140255913 | ANALYSIS DEVICE, ANALYSIS METHOD, OPTICAL ELEMENT AND ELECTRONIC APPARATUS FOR ANALYSIS DEVICE AND ANALYSIS METHOD, AND METHOD OF DESIGNING OPTICAL ELEMENT - An analysis device includes an optical element which includes a metal layer, a light transmitting layer provided on the metal layer to transmit light, and a plurality of metal particles arranged at a first interval P1 in a first direction and arranged at a second interval P2 in a second direction intersecting the first direction on the light transmitting layer, P12014-09-11 | |
20140255914 | COMPOSITIONS AND METHOD FOR DETECTING HUMAN PARVOVIRUS NUCLEIC ACID AND FOR DETECTING HEPATITIS A VIRUS NUCLEIC ACIDS IN SINGLE-PLEX OR MULTIPLEX ASSAYS - Nucleic acid oligomers specific for human parvovirus genomic DNA are disclosed. An assay for amplifying and detecting human parvovirus genotypes 1, 2 and 3 nucleic acid in biological specimens is disclosed. Compositions for amplifying and detecting the presence of human parvovirus genotypes 1, 2 and 3 genomic DNA in human biological specimens are disclosed. | 2014-09-11 |
20140255915 | ASSAY FOR DETECTION OF JC VIRUS DNA - In one aspect, the disclosure provides methods for isolating nucleic acid from a Cerebrospinal Fluid (CSF) sample. In one aspect, the disclosure provides methods for determining the amount of JC virus DNA in a sample. | 2014-09-11 |
20140255916 | SEROLOGY ASSAYS - The invention provides methods and kits for measuring the ability of a test sample to inhibit the binding of a receptor expressed by a pathogen to a host cell ligand of the pathogen. | 2014-09-11 |
20140255917 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS - The present disclosure relates to new polymethine compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications. | 2014-09-11 |
20140255918 | Compositions, Devices, Systems, and Methods for Using a Nanopore - The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 2014-09-11 |
20140255919 | MULTIBASE DELIVERY FOR LONG READS IN SEQUENCING BY SYNTHESIS PROTOCOLS - The present technology relates to molecular sciences, such as genomics. More particularly, the present technology relates to methods for obtaining long lengths of sequencing data. | 2014-09-11 |
20140255920 | RHODAMINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS - The present invention relates to new rhodamine compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications. | 2014-09-11 |
20140255921 | ENZYME METHOD - The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore. | 2014-09-11 |
20140255922 | Cotton polymorphisms and methods of genotyping - Polymorphic cotton DNA loci useful for genotyping between at least two varieties of cotton. Sequences of the loci are useful for providing the basis for designing primers and probe oligonucleotides for detecting polymorphisms in cotton DNA. Polymorphisms are useful for genotyping applications in cotton. The polymorphic markers are useful to establish marker/trait associations, e.g. in linkage disequilibrium mapping and association studies, positional cloning and transgenic applications, marker-aided breeding and marker-assisted selection, hybrid prediction and identity by descent studies. The polymorphic markers are also useful in mapping libraries of DNA clones, e.g. for cotton QTLs and genes linked to polymorphisms. | 2014-09-11 |
20140255923 | DISCRIMINATION OF BLOOD TYPE VARIANTS - The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r′s, RHD*DIIIa and RHD*DIVa-2. The method comprises amplifying by PCR a sample obtained from a human subject at intron 3 of the RHD gene locus. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention. | 2014-09-11 |
20140255924 | TWIST-TIE OLIGONUCLEOTIDE PROBES - A composition comprising population of labeled oligonucleotides is provided herein. In some embodiments, the probes are of the formula: T | 2014-09-11 |
20140255925 | MODIFIED RNASE H ENZYMES AND THEIR USES - The invention provides a provides improvements to assays that employ RNase H cleavage for biological applications related to nucleic acid amplification and detection, where the RNase H has been reversibly inactivated. | 2014-09-11 |
20140255926 | NUCLEIC ACID BEACONS FOR FLUORESCENT IN-SITU HYBRIDISATION AND CHIP TECHNOLOGY - The present invention relates to beacons for fluorescent in-situ hybridisation and chip technology. | 2014-09-11 |
20140255927 | RNA SPLICING ALTERATIONS AND U1 SMALL NUCLEAR RIBONUCLEOPROTEINS IN NEURODEGENERATIVE DISEASES - This disclosure relates to methods of diagnosing neurodegenerative disease by analyzing proteins or protein expression profiles in a subject, or RNA or RNA expression profiles in a subject. In certain embodiments, the disclosure contemplates the diagnosis of preclinical or symptomatic stages of Alzheimer's disease, mild cognitive impairment, or chronic traumatic encephalopathy by identification of components of U1 small nuclear ribonucleoproteins or fragments thereof which are capable of forming cytoplasmic tangle-like structures. | 2014-09-11 |
20140255928 | METHODS FOR TRUE ISOTHERMAL STRAND DISPLACEMENT AMPLIFICATION - Methods, primers and probes are provided for the isothermal amplification and detection, without denaturation, of double stranded nucleic acid targets for polymerase strand displacement amplification (“iSDA”). The methods and compositions disclosed are highly specific for nucleic acid targets with high sensitivity, specificity and speed that allow detection of clinical relevant target levels. The methods and compositions can easily be used to amplify or detect nucleic acid targets in biological samples. | 2014-09-11 |
20140255929 | MOSAIC TAGS FOR LABELING TEMPLATES IN LARGE-SCALE AMPLIFICATIONS - The invention relates to methods of labeling nucleic acids, such as fragments of genomic DNA, with unique sequence it referred to herein as “mosaic tag,” prior to amplification and/or sequencing. Such sequence tags are useful for identifying amplification and sequencing errors. Mosaic tags minimize sequencing and amplification artifacts due to inappropriate annealing priming, hairpin formation, or the like, that may occur with completely random sequence tags of the prior art. In one aspect, mosaic tags are sequence tags that comprise alternating constant regions and variable regions, wherein each constant region has it position in the mosaic tag and comprises a predetermined sequence of nucleotides and each variable region has a position in the mosaic tag and comprises a predetermined number of randomly selected nucleotides. | 2014-09-11 |
20140255930 | Materials and Methods Related to Dopamine Dysregulation Disorders - The present invention provides methods of identifying an increased risk of a dopamine dysregulation disorder in a human subject, including identifying increased risk of dementia, Parkinson's disease, Huntington's, epilepsy, mania, attention deficit disorder, anxiety, dyslexia, schizophrenia, depression, obsessive-compulsive disorders, alcoholism, obesity, addiction disorders, pathological gambling, attention deficit hyperactivity disorder, bipolar disorder, Tourette syndrome, substance dependence, sub stance abuse, substance overdose, and substance-related death. | 2014-09-11 |
20140255931 | SEQUENCE ASSEMBLY - The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig. | 2014-09-11 |
20140255932 | Genotypes, Alleles and Molecular Markers Associated With Asian Soybean Rust, as Well as Methods, Processes and Uses Thereof - The present invention relates to screening methods for rust resistance or tolerance, in particular, Asian soybean rust (ASR— | 2014-09-11 |
20140255933 | SAMPLE ANALYSIS CHIP, SAMPLE ANALYSIS METHOD AND GENE ANALYSIS METHOD - A sample analysis chip of the present invention includes a base, a plurality of wells that are disposed on the base, a main channel, a first buffer portion that is in communication with a first end of the main channel and is capable of accommodating a portion of the solution, a second buffer portion that is in communication with a second end of the main channel and is capable of accommodating a portion of the solution, a solution supply channel a first end of which is in communication with the first buffer portion and a second end of which is opened to the atmosphere, an air vent channel a first end of which is in communication with the second buffer portion and a second end of which is opened to the atmosphere, and the channel that is disposed on the base and connected to the plurality of wells. | 2014-09-11 |
20140255934 | METHOD AND DEVICE FOR IDENTIFICATION OF NUCLEATED RED BLOOD CELLS FROM A MATERNAL BLOOD SAMPLE - A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman. | 2014-09-11 |
20140255935 | ULTRAFAST SEQUENCING OF BIOLOGICAL POLYMERS USING A LABELED NANOPORE - Methods and systems for sequencing a biological molecule or polymer, e.g., a nucleic acid, are provided. One or more donor labels, which are attached to a pore or nanopore, may be illuminated or otherwise excited. A polymer having a monomer labeled with one or more acceptor labels, may be translocated through the pore. Either before, after or while the labeled monomer of the polymer passes through, exits or enters the pore, energy may be transferred from the excited donor label to the acceptor label of the monomer. As a result of the energy transfer, the acceptor label emits energy, and the emitted energy is detected in order to identify the labeled monomer of the translocated polymer and to thereby sequence the polymer. | 2014-09-11 |
20140255936 | DETECTING FRONTOTEMPORAL DEMENTIA AND AMYOTROPHIC LATERAL SCLEROSIS - This document provides methods and materials for detecting a nucleic acid expansion. For example, methods and materials for detecting the presence of an expanded number (e.g., greater than 30, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, or more copies) of a hexanucleotide repeat (e.g., GGGGCC) in the non-coding region of a C9ORF72 gene are provided. | 2014-09-11 |
20140255937 | MUTATIONAL ANALYSIS OF JAK2 - An assay for mutations in JAK2 is described. The assay uses selective amplification of mutant alleles with a blocker probe which preferentially hybridises to wild type alleles. The same probe is then used to detect presence or absence of wild type sequences. It is not necessary to know the specific mutant sequence beforehand. | 2014-09-11 |
20140255938 | METHOD FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISM IN NUCLEIC ACID - A method for detecting a single nucleotide polymorphism in nucleic acids, characterized in that the method includes mixing (A) a nucleic acid probe comprising a nucleotide sequence complementarily hybridizable to an evaluation subject nucleic acid/an antisense strand thereof containing at least one single nucleotide polymorphism, and tagged with a nucleotide sequence of a hairpin structure having a bulge at a 5′-terminal thereof, wherein a guanine residue is introduced at an adjoining position of the bulge, and wherein a naphthyridine derivative compound is immobilized to the bulge; and (B) the evaluation subject nucleic acids; and detecting a signal ascribed to the naphthyridine derivative compound when the above nucleic acid probe and the above evaluation subject nucleic acids are hybridized, thereby evaluating the above single nucleotide polymorphism. | 2014-09-11 |
20140255939 | NUCLEIC ACID-BASED LINKERS FOR DETECTING AND MEASURING INTERACTIONS - The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other. | 2014-09-11 |
20140255940 | MULTI-WELL PLATE AND METHOD OF USE - A biological sample well plate includes a plate member having a top surface and a plurality of wells therein, each well being defined by an opening in the plate member top surface and an inner well surface that slopes downwardly to a well bottom having an upwardly extending projection, such that each well bottom of the plurality of wells defines a circumferential trough. | 2014-09-11 |
20140255941 | RECEPTOR GENE FOR PEPTIDE CANCER ANTIGEN-SPECIFIC T CELL - The invention provides the nucleotide sequence and amino acid sequence of the CDR3 domain of the T cell receptor (TCR) gene of a WT1-specific cytotoxic T cell (CTL) against WT1 protein. Also provided are a method for testing for and treating cancer using the nucleotide sequence and amino acid sequence, and a chip, primer set, kit, and device for testing for cancer comprising the nucleotide sequence and amino acid sequence. | 2014-09-11 |
20140255942 | METHOD FOR PRODUCING PLURIPOTENT CELL USING BACTERIUM HAVING FERMENTATION ABILITY - It is an object of the present invention to provide a method for producing pluripotent cells that are free of the risk of cellular canceration and that can be applied to regenerative medicine with a high degree of safety. The present invention provides a method for producing pluripotent cells from somatic cells comprising a step of bringing bacteria having fermentation ability or a component or secretory product thereof into contact with somatic cells. | 2014-09-11 |
20140255943 | METHODS AND COMPOSITIONS FOR THE EXTRACTION AND AMPLIFICATION OF NUCLEIC ACID FROM A SAMPLE - Provided herein are methods, compositions and kits to extract and relatively enrich by physical separation or amplification short base pair nucleic acid in the presence of a high background of genomic material (e.g., host or maternal nucleic acids). | 2014-09-11 |
20140255944 | MONITORING TREATMENT-RESISTANT CLONES IN LYMPHOID AND MYELOID NEOPLASMS BY RELATIVE LEVELS OF EVOLVED CLONOTYPES - The invention is directed to a method of monitoring or detecting treatment-resistant clones in a patient being treated for a lymphoid or myeloid neoplasm from which patient-specific correlating clonotypes have been identified. In some embodiments, such method includes the steps of obtaining a sample from the patient comprising T-cells and/or B-cells; amplifying molecules of nucleic acid from the T-cells and/or B-cells of the sample, the molecules of nucleic acid comprising recombined DNA sequences from T-cell receptor genes or immunoglobulin genes; sequencing the amplified molecules of nucleic acid to form a clonotype profile; determining from the clonotype profile a level of each correlating clonotype and clonotypes clonally evolved therefrom; and correlating a presence of a treatment-resistant clone of the neoplasm with a change in relative levels of the correlating clonotypes and clonotypes clonally evolved therefrom. In part, the invention permits one to distinguish between cases where treatment is effective but insufficiently intense and cases where a cancer clone arises that is resistant to a current treatment approach. | 2014-09-11 |
20140255945 | CALIBRATION DEVICE FOR A THERMAL CYCLER - The present invention relates to a calibration device and method for use in calibrating a thermal cycler having a reaction zone ( | 2014-09-11 |
20140255946 | CHIP-BASED DROPLET SORTING - A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting. | 2014-09-11 |
20140255947 | METHOD FOR MONITORING, DIAGNOSIS AND/OR PROGNOSIS OF HYPOXIA RELATED DISORDERS USING NFAT5 - The present invention relates to a method for monitoring, diagnosis and/or prognosis of hypoxia related disorders using NFAT5, the method comprising the steps of a) providing a body sample; b) concentrating the transcription factors present in the sample; c) detecting and/or quantifying NFAT5 in the treated sample. The invention further comprises a diagnostic kit for determining the presence and/or level of NFAT5, for simple determination of the onset of an hypoxia related disorder or condition in a subject, the kit comprising means for concentrating the transcription factors present in the sample and means for detecting NFAT5. | 2014-09-11 |
20140255948 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS - The present invention relates a simple method for evaluating free eukaryotic cell nuclei for biomarkers of DNA damage and/or transcription factor activation, activity, or expression levels and/or epigenetic modifications to chromatin or chromatin-associated factors. The invention also teaches useful strategies for combining nuclear biomarkers into a matrix of endpoints that are capable of elucidating genotoxicants' primary mode of DNA-damaging activity. Kits for conducting methods according to the invention are also described. | 2014-09-11 |
20140255949 | KIT FOR DETERMINATION OF THYMIDINE KINASE ACTIVITY AND USE THEREOF - An assay kit for determination of thymidine kinase (TK) activity in a biological sample, such as blood, serum, plasma, Cerebral Spinal Fluid (CSF), pleural fluid, ascites, tissues, cells and extracts thereof, is described. The assay kit can used in a method that comprises contacting, in a buffer, a Basic Reaction Mixture comprising: solid surface-attached primer and/or template, a modified deoxy nucleoside, such as BromodeoxyUridine, IododeoxyUridine, FluorodeoxyUridine or VinyldexoyThymidine as a kinase enzyme substrate, a phosphate donor, a nucleotide polymerizing enzyme, and a kinase enzyme source devoid of TK activity, such as a yeast extract, with the biological sample. After incubation the amount of modified deoxy nucleoside that has been incorporated into the solid surface-attached primer and/or template, is determined and the TK activity present in the biological sample is directly proportional to the amount of incorporated modified deoxy nucleoside. The assay kit are useful in the diagnosing, prognosis monitoring of disease progression and treatment effects of cell-proliferation disorders or diseases, such as cancer, and in the screening of compounds, e.g. new drug candidates, affecting enzymatic pathways, which may obstruct the formation of thymidine phosphates or interfere with nucleic acid synthesis. | 2014-09-11 |
20140255950 | HERG1 AND GLUT-1 IN COLORECTAL CANCER - The present invention describes the determination of the prognostic impact of hERG1 potassium channels along with other hypoxia-related biomolecular parameters, in patients who underwent radical surgery with curative intent for non metastatic CRC. | 2014-09-11 |
20140255951 | ANTIBODIES THAT BIND TO LYSYL OXIDASE-LIKE 2 (LOXL2) AND METHODS OF USE THEREFOR - The present disclosure provides lysyl oxidase-like-2 (LOXL2) polypeptide binding agents, including, for example, antibodies that specifically bind a LOXL2 polypeptide; and further provides compositions comprising same. The binding agents can be used in various treatment and diagnostic methods, which are also provided. | 2014-09-11 |
20140255952 | DEGRADABLE CARBON NANOTUBE-CONTAINING BIOSENSORS AND METHODS FOR TARGET CLINICAL MARKER DETECTION - The invention relates to carbon nanotube-containing composites as biosensors to detect the presence of target clinical markers, methods of their preparation and uses in the medical field. The invention is particularly suitable for the detection in patient biological specimens of bone markers and tissue markers. The biosensors of the invention include carbon nanotubes deposited on a substrate, gold nanoparticles deposited on the carbon nanotubes and, binder material and biomolecule deposited on the gold-coated carbon nanotubes. The biomolecule is selected to interact with the target clinical markers. The biosensor can be used as an in-situ or an ex-situ device to detect and measure the presence of the target clinical markers. | 2014-09-11 |
20140255953 | GRANZYME A AND GRANZYME B DIAGNOSTICS - A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin. | 2014-09-11 |
20140255954 | METHOD OF BREAST CANCER DETECTION - Methods of diagnosing breast cancers are provided. The methods include analyzing the expression patterns of biomarkers in a plurality of cells to distinguish between invasive and non-invasive cancers, usual and atypical hyperplasias, and basal-like breast cancers. Breast cancers are diagnosed based upon different combinations of the biomarkers found in nipple aspirate fluid. | 2014-09-11 |
20140255955 | METHOD OF DIAGNOSING SJOGREN'S DISEASE - Provided are methods and compositions for determining whether an individual has Sjögren's disease (SD). The method entails determining in a biological sample from the individual the presence of antibodies directed to salivary gland protein 1 (SP-1), parotid secretory protein (PSP), carbonic anhydrase 6 (CA6), or determining a combination of the antibodies. Determining that the individual has SD is based on the presence of the antibodies. The method provides for detection of early SD. Kits for antibody detection containing the antigens to which the antibodies of SD patients are directed are also provided. | 2014-09-11 |
20140255956 | DIAGNOSIS OF MYOCARDIAL AUTOIMMUNITY IN HEART DISEASE - Provided herein are, inter alia, methods of diagnosing myocardial autoimmunity in subjects by detecting the presence of autoantibodies to cardiac antigens in the subjects. | 2014-09-11 |
20140255957 | Antigens Derived from Citrullinated 14-3-3 and Uses Thereof in the Diagnosis of Rheumatoid Arthritis - The present invention provides citrullinated 14-3-3η peptides and antibodies thereto and methods of using same to evaluate arthritic conditions such as rheumatoid arthritis. | 2014-09-11 |
20140255958 | MEMBRANE SENSOR CAPABLE OF SEQUENTIALLY CHANGING REACTION CONDITION BY SINGLE SAMPLE INJECTION - Disclosed herein are a membrane sensor capable of changing a reaction condition by a single sample injection and a method for measuring a reaction using the same, and more specifically, a membrane sensor designed so that a bio reaction having two or more reaction conditions is sequentially generated by a single sample injection, by forming an asymmetric membrane between a reactant storing part and a reaction membrane. | 2014-09-11 |
20140255959 | CHOLESTEROL OXIDASE MUTANTS, COMPOSITIONS, DEVICES, KITS AND USES THEREOF - Compositions, devices, kits and methods are disclosed for assaying cholesterol with a cholesterol oxidase mutant that has been modified at an amino acid residue involved in the active site. The cholesterol oxidase mutant has reduced oxidase activity while substantially maintaining its dehydrogenase activity. | 2014-09-11 |
20140255960 | SYSTEMS AND METHODS FOR TEST STRIPS WITH EXTENDED DYNAMIC RANGES - An extended range test strip includes a simple system where the end user can determine the concentration of the analyte at high concentration with a single drop of whole blood. A single drop of blood spreads across a spreading layer and into multiple reagent stacks. Multiple reagent stacks of the test strip may be configured to test for different ranges by adding a peroxide modulator. Readings from multiple reagent stacks producing a colorimetric response may be tested simultaneously. Working from the lowest range to the highest range of reagent stacks, the first reagent stack to be less than its maximum range is considered to be the reagent stack that is producing a colorimetric response related to the actual amount of analyte in the sample. | 2014-09-11 |
20140255961 | SYNTHETIC MICROFLUIDIC SYSTEMS FOR WOUND HEALING AND HEMOSTASIS - A method of assaying wound healing can include: growing cells on the matrix in the first flow channel; introducing an agent that removes the matrix from the junction; introducing a matrix material into the second flow channel so as to form the second matrix in the second flow channel and junction; and detecting cellular migration into the junction onto the second matrix. The agent that removes the matrix can include a biomolecule or chemical agent. The method can include removing cells in the matrix in the junction before introducing the matrix material into the second flow channel. A bioactive agent can be introduced into the junction to determine if it modulates cellular migration and/or clot formation into the intersection openings of tissue and vascular channels. | 2014-09-11 |
20140255962 | SYMMETRICAL TEST ELEMENT FOR DETECTING AN ANALYTE - Test elements are disclosed for detecting at least one analyte in a body fluid. The test element include at least one strip-shaped carrier element and at least one test field having at least one test chemistry for detecting the analyte. The test element has a symmetrical shape such that the test element may be inserted in one of at least two different correct measurement orientations into a test element receptacle of a testing device, which includes a detection device. In the different orientations, at least one analyte-induced change in the test chemistry of the test field is detectable. Test systems including the test elements and methods of detecting at least one analyte in the body fluid using the test elements also are disclosed. | 2014-09-11 |
20140255963 | Degradable Detergents - Methods and materials relate to degradable detergents. The degradable detergents have degradable linkages that are cleaved when subjected to elevated temperature and/or reduced pressure. The detergents are compatible with spectrometric analysis, such as mass spectrometry. The surfactant comprises at least one fluorinated alkyl moiety and at least one cleavable moiety, wherein the surfactant degrades into a plurality of volatile degradation products when injected into a mass spectrometer. | 2014-09-11 |
20140255964 | ANALYTICAL METHOD OF POST-TRANSLATIONAL MODIFICATIONS IN HEMOGLOBIN - An analytical method of post-translational modifications in hemoglobin is disclosed. The analytical method comprises the steps of providing a blood comprising the hemoglobin with post-translational modification of nitration, nitrosylation, or oxidation; performing an extraction process to the blood by an organic solvent; quantifying the hemoglobin by a fluorescent spectrometry; hydrolyzing the hemoglobin into a plurality of peptides by an enzyme; and using a nanoflow liquid chromatography-nano spray ionization tandem mass spectrometry to characterize and quantify the post-translational modifications of the hemoglobin. | 2014-09-11 |