| 36th week of 2012 patent applcation highlights part 33 |
| Patent application number | Title | Published |
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| 20120225390 | SUBSTRATE TREATMENT METHOD, SUBSTRATE TREATMENT APPARATUS, AND NON-TRANSITORY COMPUTER STORAGE MEDIUM - A substrate treatment method of performing treatment on a substrate on which a pattern mask has been formed by exposure and developing treatment to improve roughness of the pattern mask includes the processes of: mounting the substrate on a stage in a treatment container; and repeating a plurality of times steps of supplying a solvent gas to a center portion of the substrate while exhausting the solvent gas from a periphery of the substrate to swell the pattern mask, and then supplying a drying gas for drying the solvent supplied to the substrate to the center portion of the substrate while exhausting the drying gas from the periphery of the substrate. | 2012-09-06 |
| 20120225391 | APPARATUS AND METHOD FOR ROTATING A FIRE, A FLAME, A SMOKE PLUME, OR FOR CIRCULATING HEAT AND CANDLE ASSEMBLY THEREFOR - A candle assembly is provided having at least one wick, the candle assembly formed of at least two wax parts which interface together to allow selective juxtaposition of wax parts having desired color combinations, scents, and wax compositions. The parts, when fit together conform to in inner form of a receptacle, and are held together with the at least one wick in such receptacle. Optionally, at least one part has a recess into which the at least one wick may be held in place or positioned to facilitate accurate assembly. | 2012-09-06 |
| 20120225392 | CANDLE HAVING A PLANAR WICK AND METHOD OF AND EQUIPMENT FOR MAKING SAME - A candle or candle apparatus includes a body of a meltable fuel and a planar wick provided in the body. The planar wick includes a material selected from a wood, wood product, semi-wood composition, and wood-like material. The planar wick has a height dimension, a width dimension, and a thickness dimension, the height dimension is greater than the width dimension, the width dimension is greater than the thickness dimension, and the thickness dimension is from 0.019 to 0.23 inches | 2012-09-06 |
| 20120225393 | GAS BURNER - The present invention relates to a gas burner in which a burner body and a side plate are assembled together without a welding process, to thereby simplify manufacturing procedures and reduce manufacturing costs. To accomplish this, the gas burner of the present invention includes a plurality of burner units ( | 2012-09-06 |
| 20120225394 | DELIVERY CHUTE FOR SINTER MATERIAL - A delivery chute for delivering sinter material onto a sinter cooler and a method for delivering sinter material from a sinter belt onto a sinter cooler are provided. The sinter material introduced into the delivery chute may be divided by distributor plates into at least two sinter material subflows flowing in different directions, which may be guided into the edge regions of a sinter material total flow obtained by combining them. | 2012-09-06 |
| 20120225395 | METHOD AND SYSTEM FOR LIMITING WATER BOILER HEAT INPUT - A method to control the heat input into a boiler utilizing the boiler return temperature to minimize the heat input and maximize the efficiency of the boiler. | 2012-09-06 |
| 20120225396 | HEATER ASSEMBLY - A heater assembly for a tank | 2012-09-06 |
| 20120225397 | DEVICE FOR PLACING A DENTAL SPLINT | 2012-09-06 |
| 20120225398 | Orthodontic Archwire And Bracket System - The invention is an archmatrix. In one embodiment the archmatrix of the invention comprises: an occlusal wire; an apical wire; and a plurality of connecting elements located between the occlusal wire and the apical wire (see, e.g., FIG. | 2012-09-06 |
| 20120225399 | METHODS FOR ORTHODONTIC DEVICES - Embodiments presented herein provide methods for forming and coupling an attachment device onto teeth. An embodiment of a method comprises providing a template including a prescribed number and placement of apertures, disposing the template over the teeth exposing tooth surface through each aperture, and disposing an attachment mold through each respective aperture to the tooth surface. The attachment mold includes a mold bore suitable for providing a mold for forming an attachment device of a desired shape from curable material. The method further includes removably coupling the attachment mold to the tooth surface with the mold bore defining target tooth surface, disposing curable material within the mold bore and in contact with the target tooth surface, curing the curable material to a hardened state to form an attachment device that is coupled to the target tooth surface, removing the template, and removing the attachment mold from the attachment device. | 2012-09-06 |
| 20120225400 | SYSTEM AND METHOD FOR POSITIONING TEETH - Methods and apparatus fit a set of upper and lower teeth in a masticatory system by generating a computer representation of the masticatory system and computing an occlusion based on interactions in the computer representation of the masticatory system. | 2012-09-06 |
| 20120225401 | SYSTEM AND METHOD FOR DETECTING DEVIATIONS DURING THE COURSE OF AN ORTHODONTIC TREATMENT TO GRADUALLY REPOSITION TEETH - Method and system for detecting and correcting deviation during an orthodontic treatment plan is provided. The method includes the steps of receiving an un-segmented current teeth image representing a patient's teeth after an orthodontic treatment plan has begun and before the plan ends for the patient; matching a previously segmented teeth model with the current teeth image; and generating at least one corrective stage to define an intermediate tooth arrangement, wherein the at least one corrective stage repositions a digital teeth image so that a prescribed tooth arrangement of the previously segmented teeth model can be used. | 2012-09-06 |
| 20120225402 | NOVEL DENTAL APPLIANCES AND METHODS FOR THEIR FABRICATION - The invention consists of a rapidly crosslinkable, two-component silicone elastomer together with a specially designed tray that serves as a form for the silicone resin and forms an integral portion of a dental appliance. | 2012-09-06 |
| 20120225403 | STAND FOR DENTAL TECHNICAL MATERIAL - The present invention provides a stand for a dental technical material which is capable of increasing flexibility and reducing difficulty in arranging a dental model. | 2012-09-06 |
| 20120225404 | PROCESS FOR CLEANING TEETH - The present invention is in the field of tooth cleaning devices, especially electrical toothbrushes. The invention further relates to the use of an air/water jet for the cleaning of teeth. A process for cleaning teeth that incorporates a water jet for cleaning teeth remains to be desired, especially a single device that can be employed to clean teeth and reliably deposit material onto teeth. It is therefore an object of the present invention to provide a process for cleaning teeth with an electrical toothbrush device providing improved cleaning by means of an externally mixed air-water jet wherein the water dosing is not influenced by the air pressure. Surprisingly it has been found that a tooth brush device, comprising an air/water jet, wherein the air and water are mixed outside the nozzle(s), provides improved cleaning of dental surfaces, including inter-proximal areas, with low usage of water. | 2012-09-06 |
| 20120225405 | PLUNGER FOR A SYRINGE AND METHOD OF MAKING SUCH A PLUNGER - A plunger for advancing a substance in a syringe toward a dispensing nozzle. The plunger has a plunger rod and a seal and being formed of a plastic composition. The plastic composition comprises a polymer and a filler which is non-uniformly distributed within the polymer to provide the plunger rod and the seal with different mechanical properties depending on the filler content in the portions of the plastic composition plunger forming the rod and the seal. The invention preferably provides a dental syringe which can be conveniently used, and further helps minimizing costs in the manufacturing of the dental syringe. | 2012-09-06 |
| 20120225406 | ENDODONTIC TOOL AND METHOD - A reciprocating endodontic hand tool in which the torque applied to an instrument such as a debriding file does not exceed the elastic limit of the file. This reduces or eliminates opportunities for plastic distortion, fatigue and breakage of the file during the canal debriding/cleaning/shaping process. The rotational limits of the instrument may be set at levels that will not subject the instrument to a torque exceeding its elastic limit. | 2012-09-06 |
| 20120225407 | RESTORABLE ZIRCONIUM DIOXIDE-BASED ONE PIECE DENTAL IMPLANT - A restorable zirconium dioxide-based one piece implant includes an implant root made of zirconium dioxide and having a bottom coarse thread portion mounted in a gum of a patient and a top fine thread portion at a top side of the bottom coarse thread portion, an abutment formed integral with a top end of the top fine thread portion of the implant root for mounting a crown, and a vertical center hole extending vertically downwardly from a topmost edge of the abutment into the implant root toward a bottom end of the bottom coarse thread portion of the implant root and having a length greater than 2/3 of the combined length of the implant root and the abutment, so when the abutment breaks, the vertical center hole provides a space for the application of post and core technology to embed a post in the broken abutment to restore the abutment. | 2012-09-06 |
| 20120225408 | FLEXIBLE SPRING FASTENER - A connector includes a body having a helix configured to change circumferentially in response to a change in force applied to the connector, external and internal surfaces of the helix are configured to have a substantially planar contact surface, at least part of the body is hollow in an axial direction, and a portion of the internal circumference of the hollow body is tapered. | 2012-09-06 |
| 20120225409 | Method For Producing Individual Drilling Templates For Dental Implant Surgery In A Patient's Jawbone - A method for producing an individualized drilling template for dental implant surgery in a patient's jawbone is disclosed. The clinical user (dentist or dental technician) is provided with a transfer template with the aid of which the drilling template can be made on-site. The process is intended for use in dentistry. | 2012-09-06 |
| 20120225410 | Idea/process of combining a cross stitch / needlepoint / crewl design / pattern with hand painting the cloth / canvas as part of the pattern offered, or as an option, and also as a solution to repair an existing tapestry from stains or any type of damage - The purpose and process of combining cross stitch, needlepoint or crewel patterns with hand painting the cloth or canvas as part of the pattern designed and/or as a repair solution to a damaged tapestry. | 2012-09-06 |
| 20120225411 | Connector Assemblage Formational for a Dermal Communication - The present invention relates generally to electrochemical-electromagnetic integration for instructional compliance management with distributed systems, methods, devices incorporating an instructional game integrated with operations training and instruction execution within a compliance lifecycle in particularly, a connector assemblage using a metamaterial and an instructional game providing security training using an RFID ID card and a RFID reader integrating terahertz radiation where the connector assemblage is conformational to a dermal communication for reducing cyber stress improving depth perception skills. | 2012-09-06 |
| 20120225412 | INTERVENTIVE DIAGNOSTIC DEVICE - Apparatus and methods are described for facilitating improving health of a user. In accordance with some applications, a first physiological variable, which is indicative of a voluntary action of the user, is received. A second physiological variable, which is not entirely under the direct voluntary control of the user, is received. Responsive to the first and second variables, the second physiological variable is changed in a desired manner, by using circuitry to direct the user to modify a parameter of the voluntary action, by generating an output signal. Other applications are also described. | 2012-09-06 |
| 20120225413 | REAL-TIME FEEDBACK OF TASK PERFORMANCE - A method of providing real-time feedback of task performance includes receiving sensor data from sensors coupled to an object. The sensor data is received in response to tasks performed on the object and references positional data with respect to a location on the object at which tasks are performed. The method also includes applying the sensor data to a model of performance measurements, which reflect a standard of performance. The method further includes identifying any deviations of the sensor data from data in the model, and outputting feedback in real-time. The feedback includes indicators signaling tasks performed are correctly implemented and indicators signaling tasks performed are incorrectly implemented. Corrective indicators include measures for modifying task performance to achieve an outcome that approaches or meets the standard of performance. The indicators correspond to one or more locations on the object as determined by the positional data. | 2012-09-06 |
| 20120225414 | METHOD AND APPARATUS FOR TEACHING BIOLOGY USING VIRTUAL LIVING ORGANISM - Provided is a method and apparatus for teaching biology by using a virtual plant or a virtual animal. The method is displayed on a display of a computer and includes collecting growth data of an actual living organism according to different environmental conditions at a predetermined time interval and storing the collected growth data; obtaining a growth equation for each of the environmental conditions based on the growth data; designing a growth animation of the virtual living organism for each of the environmental conditions based on the growth equation; and controlling a control panel screen to fetch the growth data and the growth animation and to display a change in growth of the virtual living organism when a user inputs environmental conditions of the virtual living organism on the control panel screen, to thereby provide high practicality and high educational effects. | 2012-09-06 |
| 20120225415 | LEARNING CONTENT DELIVERY SYSTEM - A learning content delivery system is provided that includes a network, a plurality of remotely stored content delivery applications each having learning content, one or more user devices, and a platform. The platform has an application framework that allows the one or more user devices to access the remotely stored applications and learning content via the network. The applications can include at least two platform specific applications, which are developed on a common application programming interface. The platform can dynamically sense one or more attributes of each user device and to customize presentation of the learning content from the platform specific applications for the user device. The application framework can provide two-way awareness between the platform and the platform specific applications. | 2012-09-06 |
| 20120225416 | METHOD FOR ENHANCING RED BLOOD CELL QUALITY AND SURVIVAL DURING STORAGE - The present invention is a method for enhancing the quality and survival of red blood cells during storage by depleting the red blood cells of both carbon dioxide and oxygen and maintaining 2,3-diphosphoglycerate acid levels. | 2012-09-06 |
| 20120225418 | APPARATUS AND METHOD FOR SELECTING PARTICLES - The invention provides a device and a method for flow cytometric fractionation of particles contained in a fluid stream, wherein sections of the fluid stream, especially droplets if the fluid stream is a droplet stream, are irradiated with a laser. The laser disposed for the irradiation of the sections of the fluid stream can have a wavelength which is absorbed by the fluid and can have a sufficient radiation duration and radiation intensity to deflect sections of the fluid stream. | 2012-09-06 |
| 20120225419 | METHODS AND SYSTEMS FOR PROVIDING RED BLOOD CELL PRODUCTS WITH REDUCED PLASMA - Methods and systems for processing and conditioning red blood cells are disclosed. The methods and systems may be used to make a readily transfusible red blood cell product with reduced plasma. In general, the plasma content of the supernatant of the red blood cell product is no greater than about 15%. The red blood cell products are prepared using the disclosed methods and systems remain transfusible for up to 42 days. | 2012-09-06 |
| 20120225420 | BIO VAPOR STIMULATION SYSTEM - The organic material in a landfill's incoming solid waste is converted into a useful biogas (methane). A bio vapor stimulation system comprises components for mixing bacteria and nutrients and for growing bacteria, as well as process sensors, and a delivery system to provide an appropriate balance of: (1) anaerobic bacteria, (2) nutrients, and (3) humidification. Measurements of landfill site conditions, landfill gas, landfill gas condensate for temperature, pH, alkalinity, COD/BOD and gas composition, oxidation-reduction potential (ORP), volatile acid concentration, and/or other parameters are used as process control inputs. Based upon these measured indicators of the health and status of the anaerobic bacteria community within the site, various process changes may be administered such as bacteria composition, additives, nutrient composition and quantity, and temperature and ph of the liquid being fed into a carrier gas for site humidification, thereby facilitating a more efficient conversion of organic waste into biogas. | 2012-09-06 |
| 20120225421 | KIT AND METHOD FOR SEQUENCING A TARGET DNA IN A MIXED POPULATION - Methods and kits for sequencing a target DNA sequence in a sample having a related reference sequence are provided herein. In particular, kits and methods for sequencing cancer and cancer therapy associated mutations are described. Also provided are kits and methods for detecting mitochondrial mutations and for differentiating between closely related viral strains. | 2012-09-06 |
| 20120225422 | METHOD AND DEVICE EMPLOYING A NON-RECEPTOR LIGAND INTERACTION WITH NANOPARTICLES OR OTHER SOLID PHASE FOLLOWED BY SPECIFIC DETECTION - A method and apparatus for conducting specific binding assays are claimed. This invention relates to an initial non-receptor ligand interaction with nanoparticles or other solid phases followed by specific detection methods used for detecting biological, chemical or environmental entities. This invention employs an on-device ligand attachment to nanoparticles or other solid phase followed by the specific capture in discrete zones on the device. The ligand-bound complexes assemble on the ligand specific capture zone leading to a visible diagnostic result, if colored solid phases are employed. | 2012-09-06 |
| 20120225423 | PATHOGEN DETECTION BIOSENSOR - The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc receptor, and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more receptors on the emittor cell. Also provided are optoelectronic sensor devices for detecting a target particle in a sample, including in a plurality of samples. | 2012-09-06 |
| 20120225424 | Device and Method for Electroporation-Based Delivery of Molecules Into Cells and Dynamic Monitoring of Cell Responses - The present invention includes devices and methods for transfecting a cell or cell population and dynamic monitoring of cellular events. A variety of microelectronic devices are provide that incorporate functions such as electroporation, modulation of a transmembrane potential and dynamic monitoring of cellular functions and mechanisms. | 2012-09-06 |
| 20120225425 | Cathepsin E as a Marker of Colon Cancer - Elevated levels of cathepsin E (catE) are demonstrated to be diagnostic of intestinal forms of cancer, such as colorectal cancer. Elevated levels of cathepsin E (catE, monomeric forms) are demonstrated to be detectable in the urine of animals having colorectal cancer, and a diagnostic/screening method for identifying and/or detecting colorectal cancer in an animal from a urine sample is provided. Specific tissue immunohistochemcial staining for catE (monomeric forms) in dysplastic tissue is also disclosed, and is shown to correlate with the level of dysplastic lesion severity. Hence, a method for identifying and determining the level of dysplastic lesion severity is provided. Cathepsin E mRNA transcription and expression levels are also demonstrated to be upregulated in dysplastic tissue, relative to non-dysplastic tissue. Hence, a method for transcriptionally profiling an animal to monitor the progression of colorectal disease is provided. | 2012-09-06 |
| 20120225426 | BAALC EXPRESSION AS A DIAGNOSTIC MARKER FOR ACUTE LEUKEMIA - Overexpression of the gene, BAALC, in biological samples from a patient is prognostic for tumor aggressiveness and unfavorable patient outcome. The present invention provides polynucleotide primers and probes for assaying for overexpression of BAALC transcripts. Kits containing the primers and probes are also provided. Also provided are antibodies for assaying for overexpression of BAALC proteins as well as peptide immunogens for producing the anti-BAALC antibodies. The present invention also provides methods for characterizing acute myelogenous leukemia, chronic myelogenous leukemia and prostate cancer in a patient, base on detection of BAALC overexpression. | 2012-09-06 |
| 20120225427 | sPLA2 IIA Polymorphism Analysis for the Diagnosis/Prognosis of a Cardiovascular Disease/Event - The invention relates to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising determining, in a sample obtained from said subject, the presence or absence of a variant allele of nucleotide polymorphism (SNP) of the sPLA2 type IIA nucleic acid, wherein the SNP is selected from the group consisting of rs11573156 and rs2236771, wherein the presence of the minor allele (G) of SNP rs11573156 indicates an increased risk of having or being at risk of having or developing a cardiovascular disease and/or cardiovascular event, and the presence of the minor allele (C) of SNP rs2236771 indicates a decreased risk of having or being at risk of having or developing a cardiovascular disease and/or cardiovascular event. | 2012-09-06 |
| 20120225428 | TYPE OF UNIVERSAL PROBE FOR THE DETECTION OF GENOMIC VARIANTS - The present disclosure relates to a composition comprising a first set of probes and a second set of probes, composed of one or more DNA nucleotide(s) and five or more LNA (locked nucleic acid) nucleotides, wherein the base at a discriminating position differs for a first probe of the first set and a first probe of the second set. The present disclosure relates to the composition comprising a plurality of probes in each of the first and second set of probes, wherein the probes in each set differ in one, two, or three LNA random position(s). Further, the present disclosure relates to a method of detecting genomic variants by means of the aforementioned probes. | 2012-09-06 |
| 20120225429 | METHODS, COMPOSITIONS AND KITS FOR DETECTION AND ANALYSIS OF ANTIBIOTIC-RESISTANT BACTERIA - The present invention relates generally to detection of antibiotic-resistant bacteria in a sample. In particular, the invention provides methods, compositions and kits for detecting and analyzing methicillin-resistant | 2012-09-06 |
| 20120225430 | METHODS FOR DETECTING HUMAN PAPILLOMA VIRUS-ASSOCIATED CANCERS - The present invention provides probes and methods of use thereof in the diagnosis and/or prognosis of certain types of cancers, particularly human papillomavirus (HPV)-associated cancers. The probes are designed for hybridization with genomic material in a manner indicative of one or more aberrations in the genetic material present in the test sample. The identified aberrations are biomarkers of HPV-associated cancer. The methods of the invention comprise contacting a sample to one or more probes, allowing any genetic material in the sample to hybridize to the genomic regions provided in the probes, analyzing the hybridizations, and analyzing the hybridizations to identify detected aberrations as biomarkers indicative of HPV-associated cancer progression. | 2012-09-06 |
| 20120225431 | METHODS OF SYNTHESIZING AND LABELING NUCLEIC ACID MOLECULES - The present invention is generally related to composition, kits and methods for synthesizing nucleic acid molecules and particularly for synthesizing labeled nucleic acid molecules. Specifically, the invention relates to methods, kits and compositions for synthesizing indirectly labeled nucleic acid molecules. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection, diagnostics, and array analysis. | 2012-09-06 |
| 20120225432 | Method and Kit for the Prognosis of Mantle Cell Lymphoma - The method and the kit are useful as tools for classifying a patient diagnosed with mantle cell lymphoma into the category of: indolent or conventional. The method comprises: a) providing a sample from a patient suffering from mantle cell lymphoma; b) determining the level of expression of at least one gene selected from the group consisting of: RNGTT, HDGFRP3, FARP1, HMGB3, LGALS3BP, PON2, CDK2AP1, DBN1, CNR1, CNN3, SOX11, SETMAR and CSNK1E in said sample; and c) comparing the level of expression of each of the measured genes with respect to the level of expression of the same genes in a control sample; wherein the absence of expression or the underexpression of said genes with respect to the same genes in said control sample is indicative of the indolent clinical course of the MCL. | 2012-09-06 |
| 20120225433 | Gene Expression Markers for Breast Cancer Prognosis - The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer. | 2012-09-06 |
| 20120225434 | SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 2012-09-06 |
| 20120225435 | NANOPIPETTE APPARATUS FOR MANIPULATING CELLS - Disclosed herein are methods and systems for controlled ejection of desired material onto surfaces including in single cells using nanopipettes, as well as ejection onto and into cells. Some embodiments are directed to a method and system comprising nanopipettes combined with an xyz controller for depositing a user defined pattern on an arbitrary substrate for the purpose of controlled cell adhesion and growth. Alternate embodiments are directed to a method and system comprising nanopipettes combined with an xyz controller and electronic control of a voltage differential in a bore of the nanopipette electroosmotically injecting material into a cell in a high-throughput manner and with minimal damage to the cell. Yet other embodiments are directed to method and system comprising functionalized nanopipettes combined with scanning ion conductance microscopy for studying molecular interactions and detection of biomolecules inside a single living cell. | 2012-09-06 |
| 20120225436 | Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P | 2012-09-06 |
| 20120225437 | METHODS FOR IDENTIFYING INHIBITORS OF MANNAN-BINDING LECTIN ASSOCIATED SERINE PROTEASE (MASP) PROTEINS AND USES THEREOF - This disclosure is directed to methods and compositions to inhibit MASP protein activity using small molecule inhibitors. In one aspect, the disclosure is directed to methods for identifying inhibitors of MASP protein activity, including methods of screening capable of inhibiting MASP protein activity. | 2012-09-06 |
| 20120225438 | SYSTEMS AND METHODS FOR DETECTING ANIMAL PREGNANCY - Testing systems and methods are disclosed for detecting a pregnancy marker of an animal. A test kit may include a first standard with a first concentration of the marker, a second standard with a second concentration of the marker lower than the first concentration, and at least three test surfaces coated with a biomolecular recognition element selected to bind with the marker. The test may also include a reagent solution with a conjugated biomolecular recognition element that binds with the marker, and a visual indicator that produces a visually detectable change when reacting with the conjugated biomolecular recognition element bound to each test surface. A detectable change generated by the marker from the sample with an intensity greater than the first concentration yields a pregnant result, lower than the second concentration yields a not pregnant result, and between the first and second concentrations yields a retest result. | 2012-09-06 |
| 20120225439 | PROTEIN MARKERS FOR DETECTING LIVER CANCER AND METHOD FOR IDENTIFYING THE MARKERS THEREOF - The present invention relates to the diagnosis of liver cancer. It discloses the use of protein ERBB3 and protein IGFBP2 in the diagnosis of liver cancer. It relates to a method for diagnosis of liver cancer from a liquid sample, derived from an individual by measuring ERBB3 protein and IGFBP2 protein in the sample. Measurement of ERBB3 protein and IGFBP2 protein can, e.g., be used in the early detection or diagnosis of liver cancer. | 2012-09-06 |
| 20120225440 | HEPATOCELLULAR CARCINOMA PROTEIN MARKER, AND METHOD FOR DETECTION OF HEPATOCELLULAR CARCINOMA USING THE SAME - A method of detecting hepatocellular carcinoma includes using an isolated protein including an amino acid sequence represented by SEQ ID NO: 1. | 2012-09-06 |
| 20120225441 | PROTEIN MARKERS FOR DETECTING LIVER CANCER AND METHOD FOR IDENTIFYING THE MARKERS THEREOF - The present invention relates to the diagnosis of liver cancer. It discloses the use of protein ERBB3 and protein IGFBP2 in the diagnosis of liver cancer. It relates to a method for diagnosis of liver cancer from a liquid sample, derived from an individual by measuring ERBB3 protein and IGFBP2 protein in the sample. Measurement of ERBB3 protein and IGFBP2 protein can, e.g., be used in the early detection or diagnosis of liver cancer. | 2012-09-06 |
| 20120225442 | New Markers for the Diagnosis of Celiac Disease - The invention relates to new peptides and to their use in the diagnosis of celiac disease. | 2012-09-06 |
| 20120225443 | STABILIZED STANDARDS FOR BUSULFAN IMMUNOASSAY - Use of busulfan amide as stabilized standards in immunoassays for quantifying the amount of busulfan in samples of human biological fluids, methods for carrying out said immunoassay and kits for use in said immunoassay. | 2012-09-06 |
| 20120225444 | METHODS AND APPARATUS FOR FRACTIONATION-BASED CHEMICAL ANALYSES - A method for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each include portions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS-provided intensity data. A set of precursor-ions that has substantially similar intensity ratios in both sample portions is determined to be associated with the same polypeptide. | 2012-09-06 |
| 20120225445 | SEBOCYTES, SEBOCYTE CELL LINES AND APPLICATIONS THEREOF - Adipose cells (sebocytes) are described, The invention especially relates to sebaceous gland cells and to a sebaceous gland cell line with the property of being continuously grown over many sub-cultures. The sebocytes are excellently suited for useful applications. | 2012-09-06 |
| 20120225446 | PREPARATION OF THIN LAYERS OF A FLUID CONTAINING CELLS FOR ANALYSIS - Apparatus for producing thin layers of a fluid sample for analysis, has a two dimensional array of analysis chambers ( | 2012-09-06 |
| 20120225447 | COMPOSITIONS AND METHODS FOR QUANTITATIVELY MONITORING LIPIDS - Provided herein are fluorescent lipid binding proteins (FLBPs). The FLBPs comprise a lipid binding domain linked to a fluorophore, whrereby the fluorophore's fluorescence emission undergoes a spectral change upon lipid binding. Said fluorophore is selected from the group consisting of 2-dimethylamino-6-acyl-naphthalene (DAN) and RED fluorophore and said lipid binding protein is selected from the group consisting of ENTH domain of epsin 1, C2 domain of bovine lactadherin, C1B domain of protein kinase C-gamma, C2 domain of cytosolic phospholipase A2-beta, and PH domain of Bruton's tyrosine kinase PH. | 2012-09-06 |
| 20120225448 | Substrate with Photo-Controllable Cell Adhesion Property, Method for Analyzing and Fractionating Cells, and Device for Analysis and Fractionation of Cells - When cells are analyzed, fractionated, and incubated while keeping the cells alive, real-time operations can be performed more easily and the cells can be incubated while removing unnecessary cells from the incubated cells to purify the cells being incubated. Furthermore, desired cells are separated through analysis from the incubated cells, and the purity, recovery, and viability of the cells are heightened. Use is made of a substrate having photo-controllable cell adhesion properties, the substrate comprising a transparent base and, formed thereon, a film of a material which has photo-controllable cell adhesion properties and has been obtained by bonding a cell-adhesive material to a cell-non-adhesive material through photo-dissociable groups. Cell images are detected and analyzed to obtain information about the location of desired cells. On the basis of the information, a space is formed between cells and the material having photo-controllable cell adhesion properties is cut, by means of second light irradiation. Meanwhile, by means of first light irradiation, the surface of the substrate is changed from a cell-adhesive surface to a cell-non-adhesive surface, thereby separating the cell(s) from the substrate. Thus, cells can be analyzed and fractionated while keeping the cells alive. | 2012-09-06 |
| 20120225449 | Method and appraratus utilizing enzyme substrates producing slow diffusing fluorescent product appearances and chromogens, and use in combination with fast diffusing product appearances - A new method of rapid detection of cells, microorganisms, or other items is described using various combinations of indicator enzyme substrates which can yield fluorophoric and chromophoric appearances due to reaction with enzymes. An aspect of the invention is the use of a family of compounds producing both slow diffusing fluorophoric appearances and a family of compounds identified as dual enzyme substrates producing both fluorophoric and chromogenic appearances. | 2012-09-06 |
| 20120225450 | CARBOXYL-CONTAINING POLYMERS WITH IMPROVED STORAGE STABILITY AND PROCESSABILITY - The present invention relates to carboxyl-containing polymers having higher storage stability and improved processability in the form of powders, pellets or granules and to their use in laundry detergents and cleaners, and also in further fields of use. | 2012-09-06 |
| 20120225451 | METABOLIC ENGINEERING OF XYLOSE-FERMENTING EUKARYOTIC CELLS - The present invention relates to genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers on the host cell the ability to isomerize xylose to xylulose. These genetic modifications are aimed at improving the efficiency of xylose metabolism and include. e.g., reduction of nonspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source. | 2012-09-06 |
| 20120225452 | NUCLEIC ACID MOLECULE FOR ENCODING XYLOSE ISOMERASE AND XYLOSE ISOMERASE ENCODED BY THE NUCLEIC ACID MOLECULE - A novel xylose isomerase nucleotide sequence obtained from a bovine rumen fluid metagenomic library and also provides the amino acid sequence encoded by the nucleotide sequence, and a vector and a transformant containing the nucleotide sequence. When the xylose isomerase is expressed, a host cell is endowed with the capability of converting xylose into xylulose, and the xylulose is further metabolized by the host cell. Therefore, the host cell can take the xylose as a carbon source for growth. The xylose isomerase from a new source is expressed with high activity in | 2012-09-06 |
| 20120225453 | SYSTEMS AND METHODS FOR THE SECRETION OF RECOMBINANT PROTEINS IN GRAM NEGATIVE BACTERIA - Disclosed herein are systems and methods for producing recombinant proteins utilizing mutant | 2012-09-06 |
| 20120225454 | SYNTHETIC OPERON - The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a promoter operably-linked to at least two genes, wherein at least one gene is a gene of interest and at least one gene is a gene essential to said bacterium. | 2012-09-06 |
| 20120225455 | Method for Producing Sugar - Disclosed is a process for producing a sugar, whereby any non-sugar component can be removed from a sugar solution with high efficiency and the color value of the sugar solution can be reduced. Specifically disclosed is a process for producing sugar, which is characterized by comprising: adding ethanol to a sugar solution produced by squeezing a plant; removing precipitates produced by the addition of ethanol from the solution; and crystallizing sugar from the sugar solution from which the precipitates have been removed. | 2012-09-06 |
| 20120225456 | METHOD FOR CONDUCTING MULTIPLE REACTIONS IN A SINGLE REACTION TUBE - There is disclosed a method for conducting at least two reactions in a reaction tube, said method comprising the steps of providing at least two reaction phases within said reaction tube for allowing said reactions to occur therein, providing a separation phase that is immiscible with said two reaction phases and which is disposed therebetween, providing at least one particle capable of being coupled to a chemical species, wherein said particle is movable between said reaction phases to introduce said chemical species thereto. | 2012-09-06 |
| 20120225457 | NANOPARTICLE-NUCLEIC ACID COMPLEX AND METHOD OF LINEARIZING TARGET NUCLEIC ACID - A nanoparticle-nucleic acid complex and a method of linearizing a target nucleic acid by using the nanoparticle-nucleic acid complex are disclosed. By using the nanoparticle-nucleic acid complex and the method, nucleotide sequence analysis and mapping of a target nucleic acid may be efficiently performed. | 2012-09-06 |
| 20120225458 | MICROORGANISMS HAVING ENHANCED SUCROSE MUTASE ACTIVITY - The invention relates to the biotechnological production of isomaltulose and isomaltulose-containing compositions and improved means, therefore particularly microbial cells. | 2012-09-06 |
| 20120225459 | Fructanase - The present invention relates to a novel protein and a method for the manufacture thereof. The novel protein according to the invention is a recombinant protein with fructanase activity. The recombinant protein according to the invention is an engineered protein derived from recombinant DNA encoding for the protein. The recombinant protein may be or may comprise a fragment of a naturally occurring protein, i.e. of a naturally occurring fructanase protein. | 2012-09-06 |
| 20120225460 | SYSTEM AND METHOD FOR PROCESSING BIOMASS - A method for processing biomass that includes forming a first pile comprising biomass; inoculating said first pile comprising biomass; circulating a liquid in said first pile; fermenting the biomass in said first pile to produce a carboxylate salt; and extracting at least a portion of the liquid in the first pile and passing said portion of liquid to a second pile comprising biomass, wherein said second pile is operating at a higher carboxylate salt concentration than said first pile. | 2012-09-06 |
| 20120225461 | ORGANIC ACID PRODUCTION IN MICROORGANISMS BY COMBINED REDUCTIVE AND OXIDATIVE TRICABOXYLIC ACID CYLCE PATHWAYS - This invention relates to succinic acid production from renewable feedstock using microbial biocatalysts genetically modified to produce succinic acid in commercially significant quantities. More specifically, this invention relates to the genetic manipulations in the pathway of carbon from renewable feedstock to succinic acid. | 2012-09-06 |
| 20120225462 | NUTRIENT COMPOSITION FOR SACCHAROMYCES CEREVISIAE AND METHOD FOR USING THE SAME - Nutrient composition for | 2012-09-06 |
| 20120225463 | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO. | 2012-09-06 |
| 20120225464 | Specific Arabinose Transporter of the Plant Arabidopsis Thaliana for the Construction of Pentose-Fermenting Yeasts - The present invention relates to methods for conferring upon a cell the ability to take up L-arabinose, wherein said method comprises transforming the cell with a nucleic acid molecule comprising a nucleic acid sequence that codes for a plant pentose transporter, wherein the transformation enables the cell to take up L-arabinose. The present invention further relates to yeast cells that are transformed with a nucleic acid expression construct that codes for a plant pentose transporter, wherein the expression of the nucleic acid expression construct imparts to the cells the capability to take up L-arabinose. Said cells are preferably utilized for the conversion/metabolization of biomaterial containing pentose(s), in particular arabinose, and particularly for the production of bio-based chemicals and biofuels. | 2012-09-06 |
| 20120225465 | FERMENTATION OF CARBOHYDRATE - A high yield method for fermenting carbohydrate to ethanol, comprising a) treating carbohydrate with a composition containing 10-90 wt. % of an aldehyde selected from the group consisting of an formaldehyde, para-formaldehyde, glutaraldehyde and mixtures thereof, 1-50 wt. % of a surfactant having an I JLB from 4 to 18, 0-20 wt. % of an antimicrobial terpene, or essential oils, 1-50 wt. % of organic acids selected from C | 2012-09-06 |
| 20120225466 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE - The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene. | 2012-09-06 |
| 20120225467 | MODIFIED DNASE COMPOSITIONS AND METHODS OF USE THEREOF - Modified DNase polypeptides and methods of their use are provided. | 2012-09-06 |
| 20120225468 | Hafnia Phytase Variants - The present invention relates to phytases having at least 76% identity to a phytase derived from | 2012-09-06 |
| 20120225469 | ACID FUNGAL PROTEASES - The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases. | 2012-09-06 |
| 20120225470 | METHODS OF PROPAGATING MONKEY ADENOVIRAL VECTORS - The invention provides methods for propagating a monkey adenovirus in a cell including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus. including a replication-deficient monkey adenovirus, obtained by such propagation methods. | 2012-09-06 |
| 20120225471 | Method for producing a composite material - A plant essential oil emulsion is used to disinfect the raw material used in making a self-supporting composite material formed by the growth of the hyphae of a fungus into and about the discrete particles of the raw material. | 2012-09-06 |
| 20120225472 | PRESERVATION AND COMPOSITION OF BIOPROCESS ALGAE FOR PRODUCTION OF LIPIDS, SEEDSTOCK, AND FEED - The present invention relates to compositions and uses of a novel | 2012-09-06 |
| 20120225473 | Devices And Method For Enrichment And Alteration Of Cells And Other Particles - The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample. | 2012-09-06 |
| 20120225474 | SYSTEM AND METHOD FOR PATHOGEN DETECTION AND IDENTIFICATION - This disclosure concerns a pathogen inspection system that includes a handling system that presents single cells from a sample to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes within the cell. The system includes a detection facility that detects the mid-infrared wavelength light transmitted by the cell and identifies the cell as either a pathogen or not a pathogen. | 2012-09-06 |
| 20120225475 | CYTOMETRY SYSTEM WITH QUANTUM CASCADE LASER SOURCE, ACOUSTIC DETECTOR, AND MICRO-FLUIDIC CELL HANDLING SYSTEM CONFIGURED FOR INSPECTION OF INDIVIDUAL CELLS - This disclosure concerns a cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce resonant mid-IR vibrational absorption by one or more analytes, leading to local heating that results in thermal expansion and an associated shockwave. An acoustic detection facility that detects the shockwave emitted by the single cell. | 2012-09-06 |
| 20120225476 | SYSTEMS FOR THE UTILIZATION OF RUMINANT ANIMAL METHANE EMISSIONS - A process for the utilization of the methane produced by enteric fermentation, specifically to a process that utilizes methane produced by ruminant animals through enteric fermentation as a source of carbon and/or energy for the directed production of methane-based goods or processes is provided. | 2012-09-06 |
| 20120225477 | VIRAL AND VIRAL ASSOCIATED MIRNAS AND USES THEREOF - Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections. | 2012-09-06 |
| 20120225478 | ANTI-AMYLOID BETA ANTIBODIES AND THEIR USE - The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention. | 2012-09-06 |
| 20120225479 | THERMOSTABLE VARIANTS OF FIBROBLAST GROWTH FACTORS - The present technology relates to engineered human Fibroblast Growth Factor-2 (FGF2) proteins and methods of using the same. In particular, the methods and compositions relate to FGF2 mutants with increased thermostability compared to the wild-type protein and method for using the proteins in the culturing of embryonic stem cells. | 2012-09-06 |
| 20120225480 | CULTURE MEDIA, CELL CULTURES AND METHODS OF CULTURING PLURIPOTENT STEM CELLS IN AN UNDIFFERENTIATED STATE - Provided are serum-free culture media which comprise basic fibroblast growth factor (bFGF), transforming growth factor beta-3, ascorbic acid, xeno-free serum replacement and a lipid mixture. The media may also comprise an IL6R/IL6 chimera, or leukemia inhibitory factor (LIF); wherein the culture medium is capable of maintaining pluripotent stem cells in an undifferentiated state in the absence of feeder cell support. Also provided are cell cultures comprising pluripotent stem cells such as human embryonic stem cells and induced pluripotent stem (iPS) cells, and methods of using the same for expanding pluripotent stem cells in an undifferentiated state using two-dimensional or three-dimensional culture systems. Methods of expanding iPS cells in a suspension culture devoid of substrate adherence and cell encapsulation are also provided. | 2012-09-06 |
| 20120225481 | T CELL RECEPTORS - A T cell receptor (TCR) having the property of binding to the gp100 YLEPGPVTA peptide-HLA-A2 complex and comprising a TCR alpha variable domain and/or a TCR beta variable domain, characterized in that the domains are mutated relative to a TCR having the extracellular alpha and beta chain sequences SEQ ID NOs: 2 and that the TCR has a binding affinity for, and/or a binding half-life for, the YLEPGPVTA-HLA-A2 complex at least double that of a reference TCR. Embodiments of the invention such as the use of such TCRs in adoptive therapy, and fusions of such TCRs with therapeutic agents are also described. | 2012-09-06 |
| 20120225482 | MAMMALIAN CX3C CHEMOKINE ANTIBODIES - Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided. | 2012-09-06 |
| 20120225483 | Microsphere-Containing Cell Aggregate - The present invention relates to a microsphere-containing cell aggregate including: hydrogel microspheres being obtained by chemical cross-linking of one or more water-soluble synthetic macromolecules selected from the group consisting of water-soluble synthetic polymers, polysaccharides, and proteins; and cells. The present invention also relates to a method for producing the microsphere-containing cell aggregate. | 2012-09-06 |
| 20120225484 | HUMAN PLACENTAL COLLAGEN COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME - The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal. | 2012-09-06 |
| 20120225485 | METHODS FOR PRODUCING SYNTHETIC SURFACES THAT MIMIC COLLAGEN COATED SURFACES FOR CELL CULTURE - The present invention discloses methods for producing synthetic surfaces that mimic collagen coated surfaces for cell culture comprising: providing a monomer source comprising one or more organic compounds which are capable of polymerization, wherein at least one organic compound is prolinol; creating a plasma of said monomer source; and contacting at least a portion of a surface with the plasma to provide a plasma polymer coated surface. Advantageously, such methods provide an animal-free, synthetic, chemically defined surface that mimics a collagen coated surface for cell culture. Advantageously, such methods not only reduce the cost and/or issues associated with animal-derived collagen but are also amenable to large scale manufacturing. | 2012-09-06 |
| 20120225486 | DIAGNOSIS AND ASSESSMENT OF SKELETAL RELATED DISEASE USING CALCIUM 41 - A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope | 2012-09-06 |
| 20120225487 | METHOD FOR THE DETERMINATION OF POLYSORBATE 80 - The present invention relates to a method for the determination of polysorbate in a protein-containing sample. The method of the present invention involves the pretreatment of the sample by alkaline hydrolysis followed by colorimetric determination. | 2012-09-06 |
| 20120225488 | PARTICULATE MEASUREMENT SYSTEM - Disclosed is a vehicle emissions monitoring system capable of providing an accurate, real-time estimate of an amount of particulate matter (PM) within a vehicle's exhaust. The system is capable of accurately differentiating the composition of that PM by identifying amounts attributable to soot, SOF, and sulfate. | 2012-09-06 |
| 20120225489 | MEASURING COKING PROPENSITY - The present application provides a method for measuring coking propensity of a fossil fuel, comprising mixing an iron powder with a fossil fuel, wherein the iron powder has an average particle size of less than or equal to 100 μm; reacting the iron powder with the fossil fuel at a temperature and a pressure sufficient to allow coking for a period of time; separating a supernatant and a solid product after said coking; and analyzing the solid product for carbon content, wherein the carbon content is proportional to the coking propensity. There is also provided is a method for measuring effectiveness of a coking inhibitor. | 2012-09-06 |
| 20120225490 | FILTERING DEVICE - A single use filtering device comprises a filter body formed at least in part of a filter medium configured to hold a sample during filtration and a fastening element configured for releasably mounting the filtering device to a holder. The fastening element being adapted to undergo an irreversible structural alteration during the mounting or removal of the filtering device from the holder to prevent remounting of the filtering device to the holder. | 2012-09-06 |
