| 36th week of 2008 patent applcation highlights part 53 |
| Patent application number | Title | Published |
|---|
| 20080214822 | Process For the Preparation of a Leukotriene Antagonist - The present invention relates to a novel process for the preparation of montelukast sodium, a compound of Formula (1b) and precursors thereof. The invention further concerns the free acid of this compound in crystalline form, obtainable for the first time by the new process. | 2008-09-04 |
| 20080214823 | Preparation of Montelukast - A process for preparing amorphous montelukast sodium comprises removing solvent from a solution comprising montelukast sodium using agitated thin film drying. | 2008-09-04 |
| 20080214824 | Process for the Preparation of N-(4-Piperidinyl)-N-Ethyl-Phenylacetamides from N-Boc-4-Oxopiperidine - The present invention concerns a process for the preparation of an N-(4-piperidinyl)-N-ethyl-phenylacetamide of formula (I); wherein R | 2008-09-04 |
| 20080214825 | Method For Producing Substituted Halopyridines - Methods for producing substituted halopyridines (II) by reacting a β-hydroxy-y-acyl butyronitrile (I) or a suitable acyl-protected derivative with hydrogen halides, or substances or mixtures that can release hydrogen halides. In the formulae (I) and (II): R, R | 2008-09-04 |
| 20080214826 | PROCESSES FOR THE MANUFACTURE OF A PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVE - The invention is concerned with processes for the manufacture of the pyrrolidine-3,4-dicarboxamide derivative of formula (I), | 2008-09-04 |
| 20080214827 | Synthesis of Cyanoimino-Benzoimidazoles - Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof. | 2008-09-04 |
| 20080214828 | PROCESS FOR PRODUCTION OF SULFOXIDE DERIVATIVES OR SALTS THEREOF IN THE AMORPHOUS STATE - Process for producing sulfoxide derivatives or salts thereof in the amorphous state, characterized by heat-drying solvated crystals of a sulfoxide derivative or a salt thereof represented by the general formula (I): | 2008-09-04 |
| 20080214829 | Salts Having Alkoxytris(Fluoroalkyl)Borate Anions - The invention relates to salts having alkoxytris(fluoroalkyl)borate anions which on the one hand are used for the synthesis of ionic liquids, but on the other hand can be employed per se as ionic liquid, and to processes for the preparation thereof. | 2008-09-04 |
| 20080214830 | Process for Producing 2-(N-Butyl)-3-[[2'-(Tetrazol-5-Yl)Biphenyl-4-Yl]Methyl]-I,3-Diazaspiro[4,4] Non-1-En-4-One - Disclosed herein a process for producing 2-(n-butyl)-3-[[2′-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one of formula (I) in pure form by using selective solvent system and cost efficient raw materials and reagents. | 2008-09-04 |
| 20080214831 | Copper-catalysed ligation of azides and acetylenes - A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine. | 2008-09-04 |
| 20080214832 | Process for making asenapine - Asenapine and related trans-isomer bicyclic compounds can be obtained by reducing a compound of formula (C) to preferentially form a trans-isomer compound of formula (D), followed by subsequent ring closure to form a compound of formula (B) such as asenapine. | 2008-09-04 |
| 20080214833 | Process For Manufacture of Racemic Carvedilol - The invention relates to a novel process for the manufacture of Carvedilol of high HPLC purity (>99.5%) having individual impurity less than 0.1%. The product is isolated from reaction mass as a salt with suitable organic acids which on further purification is converted into the free base i.e., Carvedilol. | 2008-09-04 |
| 20080214834 | Methods For Producing Isoindole Derivatives - The present invention relates to a method for producing an isoindole derivative (compound (II)) with the following general formula (II): | 2008-09-04 |
| 20080214835 | Processes for preparing darifenacin hydrobromide - The invention encompasses processes for the preparation of darifenacin hydrobromide. | 2008-09-04 |
| 20080214836 | Process for the synthesis of lauryllactam (L12) by gas phase catalytic rearrangement of cyclododecanone oxime - The present invention relates to a process for the preparation of lauryllactam in which a Beckmann rearrangement of cyclododecanone oxime is carried out. Said process is carried out in the gas phase at a temperature of between 180 and 450° C. in the presence of a microporous material having a three-dimensional inorganic main structure composed of tetrahedra connected via a common edge, called zeolite. | 2008-09-04 |
| 20080214837 | Synthetic Method of Optically Pure (S)-3-Hydroxypyrrolidine - A method of preparing optically pure (S)-3-hydroxypyrrolidine is disclosed. The present invention provides a method of economically and industrially preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising introducing an amine protecting group by using optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, reducing a carboxylic acid group into a primary alcohol, removing the amine protecting group to form an amine salt, halogenating the primary alcohol, and amine cyclization; and through a simple purification process, i.e., distillation under reduced pressure. As another method, the present invention provides a method of preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising esterifying optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, lactam cyclization, and reduction. | 2008-09-04 |
| 20080214838 | Oligo-Tetracenes, Production and Use Thereof - Described are oligotetracenes of formula I which may either be unsubstituted or carry one or more substituents R and | 2008-09-04 |
| 20080214839 | LOW MOLECULAR WEIGHT CONJUGATED NITROGEN COMPOUNDS AND DEVICES FABRICATED USING THE SAME - Low molecular weight conjugated nitrogen compounds having linear conjugated chains, and devices fabricated using the conjugated nitrogen compounds as organic semiconductor materials, hole conducting materials, or light-emitting materials. The conjugated nitrogen compounds can be spin-coated at room temperature, are stable, and has superior electrical conductivity. | 2008-09-04 |
| 20080214840 | Reworkable thermosetting resin composition - This invention relates to thermosetting resin compositions useful for mounting onto a circuit board semiconductor devices, such as CSPs, BGAs, LGAs and the like, each of which having a semiconductor chip, such as LSI, on a carrier substrate. The compositions of this invention are reworkable when subjected to appropriate conditions. | 2008-09-04 |
| 20080214841 | High-purity biphenyltetracarboxylic dianhydride and process for producing the same - There is provided biphenyltetracarboxylic dianhydride containing biphenyltetracarboxylic monoanhydride in an amount of not more than 0.4%. By using the biphenyltetracarboxylic dianhydride as a raw material, it is possible to produce polyimide or polyamic acid having an increased molecular weight. | 2008-09-04 |
| 20080214842 | Process For Purifying Hydroxycarboxylic Acid, Process For Producing Cyclic Ester, and Process For Producing Polyhydroxycarboxylic Acid - Disclosed is a process for purifying a hydroxycarboxylic acid, comprising: a crystallization step of subjecting a hydroxycarboxylic acid aqueous solution to crystallization for purification, a separation step of separating a hydroxycarboxylic acid crystal from a mother liquid, and a washing step of washing the hydroxycarboxylic acid crystal for further purification with a washing liquid, wherein the washing liquid is a hydroxycarboxylic acid aqueous solution. The purified or refined hydroxycarboxylic acid obtained through the above process is suitably used as a starting material for production of a polyhydroxycarboxylic acid. The above process is suitably included in a process for producing a cyclic ester and a process for producing a polyhydroxycarboxylic acid. | 2008-09-04 |
| 20080214843 | Process for Manufacture of Simvastatin - An improved method for manufacture of simvastatin of formula (I) in high purity. The process for preparation of compound (I) comprises | 2008-09-04 |
| 20080214844 | Icaritin and desmethylicaritin as anti-cancer agents - The antiproliferative effects of Icaritin or Desmethylicaritin on cancer cell lines, both in vitro, and in vivo, are disclosed. Experimental data show that Icaritin and Desmethylicaritin dramatically inhibit the growth of most malignant cells. In addition, both Icaritin and Desmethylicaritin have significant Anti-agiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells. Further, no obvious side effects including nausea, hair loss or body weight loss were found in the animals treated with Icaritin or Desmethylicaritin, making both highly effective anti cancer drugs. | 2008-09-04 |
| 20080214845 | ANTIBACTERIAL 6'-MODIFIED 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS - The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection. | 2008-09-04 |
| 20080214846 | Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof - Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof. | 2008-09-04 |
| 20080214847 | Process for the Separation of Paclitaxel and Cephalomannin - Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C | 2008-09-04 |
| 20080214848 | Method For Making an Epoxy Starting From a Chlorhydrine - Process for preparing an epoxide, comprising at least one step of purifying the epoxide formed, the epoxide being at least partly prepared by a process of dehydrochlorinating a chlorohydrin, the latter being at least partly prepared by a process of chlorinating a polyhydroxylated aliphatic hydrocarbon, an ester of a polyhydroxylated aliphatic hydrocarbon or a mixture thereof. | 2008-09-04 |
| 20080214849 | PHOSPHOLIPIDS WITH UNSATURATED ALKYL AND ACYL CHAINS - The invention relates to phospholipid-like compounds having defined apolar constituents and to the use of such compounds as liposomes, active ingredients, and solubilizers. | 2008-09-04 |
| 20080214850 | ASYMMETRIC CATIONIC SURFACTANTS - A process for preparing esterquats with asymmetric side chains, including the steps of: (a) reacting one or more alkanolamines with a mixture, including: (i) 30:70% b.w. of one or more C | 2008-09-04 |
| 20080214851 | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid - The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at 2,3; 3,4; 4,5; 5,6 and other sequence positions of a fatty acid backbone. Theses novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest. | 2008-09-04 |
| 20080214852 | Process for preparing a hydrogenation catalysts - Copper compositions that are useful as hydrogenation catalysts are disclosed. In particular, the copper compounds are catalysts for the selective hydrogenation of oils that contain unsaturated fatty acyl components such as unsaturated vegetable oils. Methods of preparing the copper compositions are also disclosed. Methods of hydrogenating unsaturated compositions that contain at least two sites of unsaturation using the hydrogenation catalysts, along with products obtained from the hydrogenation reactions described herein are also disclosed. | 2008-09-04 |
| 20080214853 | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid - The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6; and other sequence positions of a fatty acid backbone. These novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest. | 2008-09-04 |
| 20080214854 | Production of isotactic and regiorandom polypropylene based polymer and block copolymers - One step ortho-alkylation of anilines with styrenes to give chiral anilines is obtained using a strong acid catalyst, e.g. CF | 2008-09-04 |
| 20080214855 | Phosphorylcholine Group Containing Compound and Surface Modifying Agent Composed of Such Compound - A phosphorylcholine group-containing chemical compound represented by the following formula (1). | 2008-09-04 |
| 20080214856 | Process for preparation of dialkyl carbonate - Provided is a process for preparation of dialkyl carbonates, comprising the step of performing oxidative carbonylation of an alcohol in liquid phase in the presence of CO and O | 2008-09-04 |
| 20080214857 | Method Of Reducing A Functional Group In An Oxidized Form - A novel method of reducing a functional group in an oxidised form. The invention relates more particularly to the reduction of aldehyde, ketone, ester, lactone, nitrile or phosphine oxide groups. The reduction method according to the invention is characterised in that it comprises exposing the substrate including the functional group to be reduced to the presence of a siloxane-type compound of the following formula (I), combined with a Lewis acid-type catalyst. In said formula (I):—R1 and R2, which are the same or different, are an alkyl, cycloalkyle or aryl group, —X is a digit from 0 to 50. | 2008-09-04 |
| 20080214858 | Composition of vinyl ether group-containing (meth) acrylic acid ester and production method thereof - It is an object of the present invention to provide a vinyl ether group-containing (meth) acrylic ester, which has both radical polymerizability and cation polymerizability, improved in storage stability and stability in handling without impairing its polymerizability or, in other words, provide a stabilized vinyl ether group-containing (meth) acrylic ester. Another object is to provide a method of producing a stabilized vinyl ether group-containing (meth) acrylic ester composition. A further object is to provide a method of stably handing, a method of economically and stably producing and a method of purifying a vinyl ether group-containing (meth) acrylic ester. A vinyl ether group-containing (meth) acrylic ester composition which comprises a radical polymerization inhibitor and a vinyl ether group-containing (meth) acrylic ester represented by the following general formula (1): | 2008-09-04 |
| 20080214859 | Process for the Preparation of Cyclopentanone Derivatives - The present invention relates to the field of organic synthesis and more particularly to a new process for the preparation of an acetal derivative of an alkyl 3-oxo-2-(2-oxoethyl)-1-cyclopentaneacetate. The invention also relates to a method to use said acetal derivative to prepare intermediates useful for the preparation of perfuming ingredients. | 2008-09-04 |
| 20080214860 | METHODS FOR THE PREPARATION OF FISPEMIFENE FROM OSPEMIFENE - The present invention concerns a method for preparation of fispemifene by use of ospemifene as a starting material. | 2008-09-04 |
| 20080214861 | Method for Producing 2-Hydroxyester Compounds - A simple and easy-to-use method for producing a 2-hydroxyester compound using a cyanohydrin compound, as a raw material, is provided. A method for producing a 2-hydroxyester compound represented by the general formula (1) (provided that ethyl 2-hydroxy-4-phenylbutyrate is excluded), wherein an acid is introduced into a mixture of a cyanohydrin compound represented by the general formula (2), an alcohol, an organic solvent and water: | 2008-09-04 |
| 20080214862 | Processes for preparing armodafinil intermediate - The present invention encompasses processes for preparing intermediates of armodafinil, and the conversion of the intermediates to armodafinil. | 2008-09-04 |
| 20080214863 | PROCESS FOR PREPARING A CATALYST CONSISTING OF A SUPPORT BODY AND A CATALYTICALLY ACTIVE COMPOSITION APPLIED ON THE SURFACE OF THE SUPPORT BODY - A process for preparing a coated catalyst in which a finely divided mixture of a multielement oxide comprising the elements Mo and V and a molybdenum oxide or a molybdenum oxide former is applied to the surface of a support body as an active composition. | 2008-09-04 |
| 20080214864 | CONTINUOUS PROCESS FOR DECARBOXYLATING CARBOXYLIC ACIDS - A continuous process for decarboxylating carboxylic acids proceeds by I.) initially charging a carbonyl compound as a catalyst in a solvent at reaction temperature, to obtain a catalyst solution; II.) metering a carboxylic acid into the catalyst solution as an aqueous solution, aqueous suspension or as a water-comprising solid, to obtain a reaction mixture; and III.) continuously removing a mixture of CO | 2008-09-04 |
| 20080214865 | Use of Polyesters in the Form of Gas Hydrate Inhibitors - The invention relates to the use of polyesters whose molecular weight ranges from 500 and 500,000 g/mol and which are obtainable by reacting a compound of formula (1), | 2008-09-04 |
| 20080214866 | Distillation Process - A mixture containing hydrogen iodide and water and having a water content of not more than 5% by weight (particularly not more than 3% by weight) in a distillation system is distilled to prevent condensation of hydrogen iodide in the distillation system. The mixture may comprise hydrogen iodide, water, methanol, methyl iodide, acetic acid, and methyl acetate. Even when the mixture contains hydrogen iodide at a concentration of 1 to 3000 ppm on the basis of weight, an acetic acid product having a concentration of hydrogen iodide of not more than 50 ppm can be obtained by withdrawing a fraction containing hydrogen iodide from the top of the column, and withdrawing acetic acid as a side-cut stream or a stream from the bottom of the column. Such a process (distillation process) effectively inhibits condensation of hydrogen iodide in the distillation system and corrosion in the distillation system. | 2008-09-04 |
| 20080214867 | Continuous Crystallisation Process of Iodinated Phenyl Derivatives - The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallisation of a crude product in a solvent with addition of anti-solvent. The continuous crystallisation process is performed in one or more crystallisers at a temperature up to the boiling point of the content of the crystalliser. | 2008-09-04 |
| 20080214868 | PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF MODAFINIL BY ASYMMETRIC OXIDATION - The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:
| 2008-09-04 |
| 20080214869 | Processes for purification of tigecycline - The invention is directed to improved processes of purifying tigecycline. | 2008-09-04 |
| 20080214870 | Method of Preparing Amine Stereoisomers - This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates. | 2008-09-04 |
| 20080214871 | Method For Producing A Xylylene Diamine - A process for preparing a xylylenediamine by heterogeneously catalyzed hydrogenation of a phthalonitrile, wherein the hydrogenation is carried out in the presence of a cobalt skeletal catalyst, of an alkali metal hydroxide and of an alcohol and/or ether as the solvent, at an absolute pressure in the range from 1 to 100 bar and a temperature in the range from 40 to 150° C. | 2008-09-04 |
| 20080214872 | METHOD FOR THE PRODUCTION OF PHENOL AND ACETONE - A method for the production of phenol and acetone from a cumene hydroperoxide mixture comprises: decomposing the cumene hydroperoxide mixture in the presence of a catalyst mixture to form a mixture comprising phenol and acetone, wherein the method further comprises: a) forming the catalyst mixture in a catalyst formation reactor by combining sulfuric acid and phenol in a weight ratio of from 2:1 to 1:1000; b) holding the catalyst mixture in the catalyst formation reactor at a temperature of about 20 to 80° C. for about 1 to 600 minutes; and c) adding the catalyst mixture to the cumene hydroperoxide mixture to form the phenol and acetone mixture. Running the process in this manner reduces the yield of hydroxyacetone and, consequently, improves the quality of the commercial phenol. Moreover, this method reduces consumption of sulfuric acid in comparison with the process in which sulfuric acid is used as catalyst. | 2008-09-04 |
| 20080214873 | METHOD FOR THE PRODUCTION OF PHENOL AND ACETONE - A method for the production of phenol and acetone from a cumene hydroperoxide mixture comprises a first stage and a second stage and at least two serially connected reactors, wherein the first stage comprises decomposition of a cumene hydroperoxide mixture in the presence of a catalyst mixture to form a dicumyl peroxide mixture, and the second stage comprises formation of a phenol and acetone mixture from decomposition of the dicumyl peroxide mixture formed in the first stage, wherein, the first stage further comprises: a) forming a catalyst mixture by combining sulfuric acid and phenol in a weight ratio of from 2:1 to 1:1000 in a catalyst formation reactor, b) holding the catalyst mixture in the catalyst formation reactor at a temperature of about 20 to 80° C. for about 1 to 600 minutes; and, c) adding the catalyst mixture to the cumene hydroperoxide mixture to form the phenol and acetone mixture. The proposed method permits a significant reduction in the yield of hydroxyacetone that causes deterioration in the quality of commercial phenol. | 2008-09-04 |
| 20080214874 | Derivatized polyhydroxystyrenes with a novolak type structure and processes for preparing the same - A process for preparing derivatized poly(4-hydroxystyrene) having a novolak type structure which comprises the steps of (i) supplying a solution of methanol containing 4-hydroxyphenylmethylcarbinol, (ii) subjecting said solution to an acid catalyzed displacement reaction for a sufficient period of time and under suitable conditions of temperature and pressure to convert substantially all of said carbinol to 4-hydroxyphenylmethylcarbinol methyl ether in solution, (iii) polymerizing said ether containing solution in the presence of a suitable acid catalyst for a sufficient period of time and under suitable conditions of temperature and pressure to form a novolak type polymer. New compositions of matter which comprise the derivatized poly(4-hydroxystyrene) prepared in the above manner and which have application in the electronic chemicals market such as in a photoresist composition, and in other areas such as in varnishes, printing inks, epoxy resins, copying paper, tackifiers for rubber, crude oil separators, and the like. | 2008-09-04 |
| 20080214875 | Purification of Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether (Sevoflurane) - Crude sevoflurane product comprising unacceptably high levels of HFIP can be purified by combining the crude sevoflurane product with sufficient water to produce a multiphase mixture, fractionally distilling the multiphase mixture, and removing substantially pure sevoflurane from the distilling multiphase mixture. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims. | 2008-09-04 |
| 20080214876 | Process for Preparation of Pharmaceutically Pure Anhydrous Calcipotriol - A process for the preparation of a pharmaceutical-grade anhydrous calcipotriol comprising: (a) dissolving crude calcipotriol having a water content of X % by weight in a first solvent or in a mixture of two or more first solvents, said first solvent or said mixture of two or more first solvents forming an azeotropic system with water, to obtain a solution of crude calcipotriol; (b) obtaining an intermediate calcipotriol by (i) placing said solution of crude calcipotriol under a reduced pressure and evaporating, if X is greater than or equal to 1, or (ii) crystallizing, if X is lower than 1; and (c) re-dissolving said intermediate calcipotriol in a second solvent or a mixture of two or more second solvents, said second solvent being anhydrous, and crystallizing at least once to obtain pharmaceutical-grade anhydrous calcipotriol. | 2008-09-04 |
| 20080214877 | Method for the Production of Enriched Isopulegol - The present invention relates to a process for preparing enriched isopulegol by crystallization from a melt comprising isopulegol. The invention relates specifically to a process for preparing enantiomerically enriched n-isopulegol proceeding from optically active isopulegol having a relatively low enantiomeric excess by crystallization from the melt. The invention further relates to a process for preparing menthol proceeding from enantiomerically and/or diastereomerically enriched n-isopulegol prepared by crystallization from the melt. | 2008-09-04 |
| 20080214878 | Method For The Production Of 1,3,5-Trifluoro-2,4,6-Trichlorobenzene From Fluorobenzene Derivatives - Method for the production of 1,3,5-trifluoro-2,4,6-trichlorobenzene from fluorobenzene comprising steps A) and B): A) chlorination of fluorobenzene derivatives of formula (II), in which X=fluorine of H, Z=nitro, bromo or chloro and n=0 or 1-4 and B) fluorination of the distillation residue and separation by distillation of the 1,3,5-trifluoro-2,4,6-trichlorobenzene thus produced. | 2008-09-04 |
| 20080214879 | Oxychlorination Catalyst and Process Using Such a Catalyst - Oxychlorination catalyst containing at least copper as an active element deposited on a support characterized in that the support consists essentially of an alumina obtained by calcination of an alumina hydrate obtained as by-product of the ALFOL® linear primary alcohol process and use of such catalyst in an oxychlorination process of a hydrocarbon containing 1 to 4 carbon atoms. | 2008-09-04 |
| 20080214880 | Process for Dehydrating Glycerol to Acrolein - The present invention relates to a process for manufacturing acrolein by gas-phase dehydration of glycerol in the presence of strongly acidic solid catalysts with a Hammett acidity H | 2008-09-04 |
| 20080214881 | Propylene polymer catalyst donor component - A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins containing magnesium, titanium, and halogen further contains an internal electron donor comprising a compound containing electron donating substituents with a structure: | 2008-09-04 |
| 20080214882 | ACIDIC MESOSTRUCTURED ALUMINOSILICATES ASSEMBLED FROM SURFACTANT-MEDIATED ZEOLITE HYDROLYSIS PRODUCTS - The surfactant-mediated hydrolysis of ZSM-5 zeolite affords five-membered ring subunits that can be readily incorporated into the framework walls of a hexagonal mesostructured aluminosilicate, denoted MSU-Z. The five-membered ring subunits, which are identifiable by infrared spectroscopy, impart unprecedented acidity to the mesostructure, as judged by cumene cracking activity at 300° C. Most notably, MSU-Z aluminosilicate made through the base hydrolysis of ZSM-5 in the presence of cetyl trimethyl ammonium ions exhibits a cumene conversion of 73%, which is 6.7-fold higher than the conversion provided by a conventional MCM-41. This approach to stabilizing zeolitic subunits through surfactant-mediated hydrolysis of zeolites appears to be general. The hydrolysis of USY zeolite under analogous hydrolytic conditions also affords zeolitic fragments that boost the acidity of the mesostructure in comparison to equivalent compositions prepared from conventional aluminosilicate precursors. | 2008-09-04 |
| 20080214883 | REACTOR FOR CARRYING OUT A CONTINUOUS OXYDEHYDROGENATION AND PROCESS - A reactor ( | 2008-09-04 |
| 20080214884 | Electroless plating in microchannels - Novel methods of electroless plating are described. Catalyst coatings can be applied within microchannel apparatus. Various reactions, including combustion and steam reforming, can be conducted over electroless catalyst coatings. | 2008-09-04 |
| 20080214885 | METHOD FOR CLEANING TAR-BEARING WASTE WATER AND APPARATUS FOR PERFORMING SAID METHOD - In a method and an apparatus for cleaning tar-bearing waste water ( | 2008-09-04 |
| 20080214886 | EVAPORATOR/CALCINER - Disclosed herein is provided an evaporator/calciner in which hazardous materials, such as radioactive liquids, are converted into chemically stable, solid forms by evaporating, drying and calcination within a single vessel, that can then be sealed and used for long term storage. | 2008-09-04 |
| 20080214887 | Brachytherapy apparatus and method using off-center radiation source - A brachytherapy applicator and method of use involve source guides that assume a desired curving, non-linear configuration. A flexible source catheter follows the shape of the source guides when inserted therein. Radiation dose received in various tissue areas can be better controlled using the invention, and the ratio of cavity surface dose to prescription depth dose can be lowered. With sequential manipulation of the source via movement of the catheter, the applicator can deliver radiotherapy to a treatment plan with local variation to prevent overdose, through either stepped or continuous movement of the source. Source guides can be fixed in position and arranged in bowed configuration around a generally central balloon axis, either attached to the balloon wall or not, and the series of off-center guides can be used to shape the dose delivered. | 2008-09-04 |
| 20080214888 | Organ Assist System and Method - An organ assist system having a closed fluid system having a ring-shaped prosthetic contactively surrounding at least a portion of a body part, including bladders adapted for selectable dilation and contraction in response to varying fluid pressure therewithin, a fluid pump, and apparatus for pressurizing the bladders; and a control unit for controlling operation of at least the fluid pump; pressure sensors within the fluid system; a power source, and shut off valves. The pressurization apparatus includes pressure cells arranged in an array, each pressure cell having a shut-off valve at its inlet, and a shut-off valve at its outlet, the shut-off valves being controlled by the control unit such that the pressurization apparatus is operable to provide a range of pressurizations to the bladders of the prosthetic for applying a controlled variable pressurizing effect to the body part thereby. | 2008-09-04 |
| 20080214889 | METHODS AND APPARATUS FOR PREVENTING TISSUE MIGRATION - Methods and apparatus for preventing tissue migration or tissue “tenting” during transseptal access procedures are described. The underlying tissue wall may be temporarily engaged via any number of mechanisms, e.g., engaging teeth or projections, threaded needle, vacuum, etc., and one or more instruments may be passed through the tissue wall while maintaining engagement with the tissue to provide a counter-traction force. The procedure may be accomplished while under direct visualization within an imaging hood placed against the tissue surface and purged of blood. | 2008-09-04 |
| 20080214890 | Therapeutic method and therapeutic system used with steps for approaching to lesion using overtube - A therapeutic system is provided, which is preferable to a treatment of pancreatic duct and biliary duct for Roux-en-Y gastrectomy patient. The therapeutic system is provided with a catheter equipped with an imaging device outputting a signal in reply to imaging, an overtube to be inserted into inside a patient, and a display displaying images based on the signal outputted from the imaging device. The overtube has an inserting channel into which the catheter is inserted, a therapeutic instrument channel into which a therapeutic instrument is inserted, an elevating base formed in an opening located at a distal end of, at least, the therapeutic-instrument channel, and an operation device to operate the elevating base. The elevating base is formed to allow a distal end portion of the therapeutic instrument to be mounted on the elevating base to elevate the distal end portion. | 2008-09-04 |
| 20080214891 | SYSTEMS AND METHODS FOR BIOFILM REMOVAL, INCLUDING A BIOFILM REMOVAL ENDOSCOPE FOR USE THEREWITH - Systems and methods of removing bacterial biofilm from a target site using a biofilm removal endoscope. The endoscope has an insertion portion including an imaging channel terminating at a viewing window and an irrigation channel terminating at a nozzle. The imaging and irrigation channels are permanently affixed relative to one another. The insertion portion is inserted into the patient, with a working end thereof being disposed proximate the target site. The target site is imaged and a flow of fluid is dispensed via the nozzle to mechanically remove bacterial biofilm from the target site. | 2008-09-04 |
| 20080214892 | Video Endoscope - A video endoscope comprises an elongate shaft having a longitudinal axis, and a handpiece at the proximal end of the shaft, a distal end of the shaft being provided with a lens and, in the proximal direction from the lens, with an electronic image pickup. The image pickup is connected, via an electrical connection extending along the shaft, to an electrical connector piece arranged on the handpiece. The image pickup and the connector piece can rotate relative to each other about the longitudinal axis of the shaft. The electrical connection comprises at least one flexible, elongate circuit board, which is able to twist about its longitudinal direction and has at least one conductor track. | 2008-09-04 |
| 20080214893 | ENDOSCOPE WITH ADJACENTLY POSITIONED GUIDING APPARATUS - An endoscope with guiding apparatus is provided. The endoscope has an elongate body with a steerable distal portion, an automatically controlled portion, a flexible and passively manipulated proximal portion, and an externally controlled and manipulatable guiding apparatus. The guiding apparatus may be positioned within the endoscope or may be positioned adjacent to the endoscope. An interlocking device is provided to slidably interlock the guiding apparatus and the endoscope. When the guide is in a flexible state, it can conform to a curve or path defined by the steerable distal portion and the automatically controlled portion. The guide can then be selectively rigidized to assume that curve or path. Once rigidized, the endoscope can be advanced along the guide in a monorail or “piggy-back” fashion so that the flexible proximal portion follows the curve held by the guide until the endoscope reaches a next point of curvature within a body lumen. | 2008-09-04 |
| 20080214894 | Robotic endoscopy actuator - A robotic endoscopy actuator is provided. The robotic endoscopy actuator includes a function means; and an energy absorption element that is operable to absorb energy from an electromagnetic field. The energy absorption element includes a heat element. The function means is operable to fulfill a function using heat energy. | 2008-09-04 |
| 20080214895 | FACE TIP ASSEMBLY FOR AN ENDOSCOPE - A face tip assembly for an endoscope for viewing a visually obscured portion of a body cavity and for surgically treating a portion of a body cavity with an operating tool may include at least one operating tool port located in an outer wall surface of the face tip assembly, and the outer wall surface may generally lie in a plane which is disposed at an acute angle with respect to the longitudinal axis of the face tip housing. This outer wall surface may have a generally U-shaped configuration. At least one optical image channel port may be located in another outer wall surface of the face tip housing, and this outer wall surface faces toward the distal end of the face tip housing. The outer wall surface in which the tool port is located extends from the outer wall surface in which the at least one optical image channel port is located, toward the distal end of the face tip housing. | 2008-09-04 |
| 20080214896 | ENDOSCOPE WITH DETACHABLE ELONGATION PORTION - Endoscopes comprising a handle and a detachable elongation portion housing a light source for illuminating the distal end of the elongation portion are provided. | 2008-09-04 |
| 20080214897 | Flexible Tube for Endoscope and Endoscope Device - A flexible tube for an endoscope and an endoscope device are provided. According to the present invention, a flexible tube for an endoscope is included in an insertion portion of the endoscope to be inserted into a body cavity and the flexible tube for the endoscope includes a bending portion provided at a distal end side and configured to perform a bending operation corresponding to an operation of an operator, and a flexible tube portion having a distal end and a proximal end and the distal end is connected to a proximal end side of the bending portion. The bending portion has a region that is bent at a first curvature radius when the bending portion is maximally bent, and at the distal end side of the flexible tube portion, a region that is set to be bent at a second curvature radius smaller than the first curvature radius when the bending portion is passively bent by a predetermined force quantity is provided. Accordingly, resistance which occurs when the bending portion is passing through the intestine bending portion is suppressed and an insertion performance of the insertion portion is increased. Thus, patients are less burdened and less painful. | 2008-09-04 |
| 20080214898 | RETRACTOR SYSTEM - The present invention provides a surgical retractor system in which first and second retractor blades are maintained in spaced relationship by a third retractor blade engaged with the first and second retractor blades. The retractor system is useful in minimally invasive surgery. | 2008-09-04 |
| 20080214899 | CRANK RETRACTOR HANDLE - The present invention relates to an apparatus for adapting a non-cylindrical serrated surgical retractor blade handle to the cylindrical bore of a universal joint. The apparatus includes an adaptor housing having a retractor handle passageway, at least a portion of the retractor handle passageway being configured to receive the slideable insertion of a non-cylindrical retractor blade handle. The adaptor housing is configured for rotational insertion into the cylindrical bore of a clamping member, thereby allowing the adaptor housing, the non-cylindrical retractor blade handle, and an attached retractor blade, to rotate about the longitudinal axis of the non-cylindrical retractor blade handle. In the illustrated embodiment, a pawl mechanism is connected to the adaptor housing and configured for automatic engagement with at least one of a plurality of serrations that are located on the non-cylindrical retractor blade handle, thereby allowing for the efficient adjustment and automatic locking of the linear position of the non-cylindrical retractor blade handle relative to the operative site. | 2008-09-04 |
| 20080214900 | METHOD AND APPARATUS FOR PROVIDING ROLLING DATA IN COMMUNICATION SYSTEMS - Methods and systems for providing data communication in medical systems are disclosed. | 2008-09-04 |
| 20080214901 | Wearable Wireless Device for Monitoring, Analyzing and Communicating Physiological Status - A wearable compact, lightweight, noninvasive, wearable “unified” device or system ( | 2008-09-04 |
| 20080214902 | Apparatus and Method for Objectively Determining Human Response to Media - An exemplary embodiment providing one or more improvements includes a media analysis apparatus and method in which human mental response to media is objectively determined. | 2008-09-04 |
| 20080214903 | Methods and Systems for Physiological and Psycho-Physiological Monitoring and Uses Thereof - The invention provides a system and method for monitoring one or more physiological parameters of a user. The system of the invention includes one or more wearable sensor modules sensing the one or more physiological parameters. One or more transmitters wirelessly transmit signals indicative of values of the one or more physiological parameters to a mobile monitor. The mobile monitor includes a processor processing the signals received from the transmitter in real time using expert knowledge. A device provides one or more indications of results of the processing. The invention also provides wearable mobile sensors for use in the system of the invention. The method of the invention includes obtaining values of the physiological parameters of the user from one or more wearable sensor modules. Signals indicative of values of the one or more physiological parameters are wirelessly transmitted to a mobile monitor. The signals are processed in real time using expert knowledge, and one or more indications of results of the processing are provided to the mobile unit. | 2008-09-04 |
| 20080214904 | Apparatus To Measure The Instantaneous Patients' Acuity Value - In a patient monitoring system ( | 2008-09-04 |
| 20080214905 | System and Method for Preventing Hypoglycaemia in a Human Type 1 Diabetic Patient During Physical Activity - A method for estimating the amount of carbohydrates needed by a DP-1 during a specific session of physical activity, comprises the following steps: defining of working constants and standard parameters; introducing of patient and therapy specific parameters, calculating of patient specific reference curves for a percentage carbohydrates consumption (% CHO); scheduling a training session; estimating the amount of carbohydrates (CHO) to be eaten before said physical activity; updating in real time the residual carbohydrates still available during said physical activity; and estimating the amount of carbohydrates to be restored after said physical activity. | 2008-09-04 |
| 20080214906 | Patient Monitoring Help Video System and Method - Embodiments of the present invention relate to a patient monitoring help screen system and method. Specifically, embodiments of the present invention include a patient monitoring device with an integral help screen system including display of video. The help screen system may provide context-sensitive help, such that the help screen accessed by a help key may relate to a specific display context. | 2008-09-04 |
| 20080214907 | Quantitative Analysis Of Skin Characteristics - Skin characteristics are analyzed. A device acquires a digital image of an area of skin of a user. A processor quantitatively analyzes the digital image to determine a characteristic of all or part of the area of skin which is indicative of a skin condition of interest. Depending on the results of the quantitative analysis, the processor provides information to the user about the area of skin relative to the condition of interest. The information provided to the user is not necessarily sufficient for a definitive medical diagnosis and may include an indication to the user as to whether a knowledgeable person should evaluate the area of skin. | 2008-09-04 |
| 20080214908 | Method and Apparatus For Monitoring the Sedation Level of a Sedated Patient - A method and an apparatus for monitoring the sedation level of a sedated patient during anaesthesia, in particular during a pre-surgical phase. The method comprises the steps of providing a skin conductance signal measured at an area of the patient's skin, calculating a derivative signal of said conductance signal with respect to time, and establishing said sedation level based on said derivative signal. | 2008-09-04 |
| 20080214909 | Catheter With Microchannels For Monitoring The Concentration Of An Analyte In A Bodily Fluid - Catheter for monitoring the concentration of an analyte in a body fluid having an implantable distal area ( | 2008-09-04 |
| 20080214910 | SYSTEM AND METHOD FOR OPERATING AN ELECTROCHEMICAL ANALYTE SENSOR - A method of operating an electrochemical analyte sensor having one or more electrodes may comprise applying a time-varying input signal to at least one of the one or more electrodes, monitoring a time-varying output signal produced by the sensor in response to application of the time-varying input signal, determining a complex impedance of the sensor based on the time-varying input and output signals, and determining from the complex impedance information relating to operation of the sensor. | 2008-09-04 |
| 20080214911 | Method and Device for Determining Blood Components Using Ratiometric Absolute Pulse Spectroscopy - The method and the device according to the invention are used for the non-invasive measurement of concentrations of blood components. At least one light source generates light using spectrophotometry and the light is guided to at least one photodetector through a tissue present at the location of application and supplied with pulsating blood. At least the measuring signal of the photodetector is guided to an evaluation unit. The light signals of a first, second, third to (n+1) | 2008-09-04 |
| 20080214912 | Blood Glucose Monitoring System And Method - An optrode for insertion into a blood vessel can include at least one fiber optic, a sheath enclosing at least part of the fiber optic and sensor material in optical communication with one end of the fiber optic. The sensor material is operative for diffracting electromagnetic waves received from the fiber optic and is responsive to changes in an amount of glucose in contact therewith for changing a diffraction of the electromagnetic waves as a function thereof. A membrane covering a distal end of the sheath passes to the sensor material glucose from blood in contact with the side of the membrane opposite the sensor material. Electromagnetic waves input into the fiber optic cable are diffracted by the sensor material. A concentration of glucose in the blood can be estimated from the amount of diffraction of the electromagnetic waves. A signal can be output related to the estimated glucose concentration. | 2008-09-04 |
| 20080214913 | Surface-Enhanced Spectroscopy with Implanted Biosensors - The present invention provides a spectroscopic apparatus, a method and a computer program product for determining the concentration of an analyte of a fluid that flows through a capillary vessel of a biological sample. The spectroscopic apparatus makes use of an imaging system for determining the position of at least one biosensing substrate that has been implanted into the biological sample in the proximity of the capillary vessel but outside the capillary vessel. The biosensing substrate is capable of inducing surface-enhanced spectroscopic effects and is preferably adapted to reversibly and selectively bind a certain analyte or molecule of the fluid, to which the vessel wall of the capillary vessel is at least semi-permeable. By performing a spectroscopic analysis not directly inside the capillary vessel but in close proximity to the capillary vessel, the signal-to-noise ratio of the spectroscopic signals obtained can be appreciably enhanced while disadvantageous scattering and interference effects can be minimized. | 2008-09-04 |
| 20080214914 | ANALYTE MONITORING DEVICE AND METHODS OF USE - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor. | 2008-09-04 |
| 20080214915 | TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. | 2008-09-04 |
| 20080214916 | Fluid Delivery With In Vivo Electrochemical Analyte Sensing - One or more therapeutic fluids, such as for example insulin can be delivered to a body. In addition or alternatively, the concentrations of one or more analytes can be measured in vivo. A feedback process can be used to regulate levels of the one or more analytes based on the measurements via delivery of the one or more therapeutic fluids. Related systems, apparatus, methods, and/or articles are also described. | 2008-09-04 |
| 20080214917 | Method and apparatus for analyte measurement test time - A method is provided for analyte measurement by a user using an analyte measurement device. An analyte measurement is provided with a plurality of penetrating members and analyte sensors. Each analyte sensor is positioned in a sample chamber with a volume no greater than 1 μl. Each sample chamber has a working electrode, reference electrode and a counter electrode. The working electrode has a conductor, an enzyme and a mediator. A penetrating member and an unused analyte detecting member are presented into an active position. The following steps are then performed: (a) the penetrating member is fired to prick the skin and bring a fluid sample to the analyte detecting member, (b) the analyte level is measured, and (c) it takes no more than 10 seconds from the step of presenting the penetrating members and unused analyte into the active position through the step of measuring the analyte level. | 2008-09-04 |
| 20080214918 | DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data. | 2008-09-04 |
| 20080214919 | SYSTEM AND METHOD FOR IMPLEMENTATION OF GLYCEMIC CONTROL PROTOCOLS - A system for implementing a wide-range of glycemic control protocols (e.g., Tight Glycemic Control protocols) in an automated, semi-closed or closed loop manner thereby eliminating common sources of system error is provided herein. More specifically, the system can include a blood glucose measuring device in communication with a wide-range of databases and/or interfaces thereby allowing for typically independent steps such as patient testing, result determination, protocol adjustment (suggestions as well as actual calculations of new dosages), meal information, scheduling of future testing in light of test results, and administration of medicine to be performed automatically in a semi-closed or closed loop manner. Furthermore, the system provides for ultimate flexibility by allowing a protocol administrator to continuously add, subtract, and/or modify various steps of the protocol while maintaining the integrity and safety of the system. Additionally, methods of implementing such glucose control protocols are also provided herein. | 2008-09-04 |
| 20080214920 | Apparatus and Method For Coupling Implanted Electrodes to Nervous Tissue - An apparatus and method for improving electrical contact between an implanted device ( | 2008-09-04 |
| 20080214921 | Attachable Surface Electrode For Laryngeal Electromyography - An electrode for laryngeal electromyography that is adhesively secured to an insert device, endotracheal tube or other similar device. The attachable surface electrode of this invention consists of a flexible substrate having an anterior and a posterior surface specifically for insertion along the human laryngopharynx and adjacent to the cricothyroideus muscles (the vocal cords). One or more electrically conductive structures are mounted on or formed on the anterior surface of the substrate to provide an electric contact with the cricothyroideus muscles. Insulated wires extend from the electrical conductive structures for transmitting electrical pulses to the cricothyroideus muscles. There is an adhesive material on the posterior surface of the flexible substrate for attachment to an endotracheal tube, insert device, postcricoid paddle or other such device of the attachable substrate so that the electrically conductive structures thereon are properly positioned for laryngeal electromyography. | 2008-09-04 |
