| 36th week of 2008 patent applcation highlights part 42 |
| Patent application number | Title | Published |
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| 20080213718 | LASER SHAPED GREEN METAL BODY AND ORTHODONTIC BRACKET - A green metal body is comprised of metal particles and a binder in the shape of an orthodontic bracket and/or base plate. The green metal body is fabricated by being laser-cut with a laser to shape the green metal body into the shape of an orthodontic bracket and/or or to carve recesses and/or undercuts into the bonding surface of the bracket. The green metal body is sintered to shrink its volume into a denser and less porous sintered metal body configured to be an orthodontic bracket. The resultant sintered orthodontic bracket includes recesses and/or undercuts in the bonding surface to provide a mechanical aspect when bonded to a tooth. | 2008-09-04 |
| 20080213719 | Temperature Modified Oral Cleaning Device - A temperature modified oral care device including a base; an electrical circuit disposed at least partially in said base; and, a heating element connected to the electrical circuit. | 2008-09-04 |
| 20080213720 | ENDODONTIC INSTRUMENTS MANUFACTURED USING CHEMICAL MILLING - A method of manufacturing endodontic files involves a chemical milling process to yield endodontic files having a desired taper and/or degree of sharpness. The process involves the steps of (a) forming helical cutting edges in the cutting portion of the metallic rod; and (b) chemically milling the cutting portion of the rod so as to sharpen and/or taper the cutting portion. The rod may be formed of any desirable metallic material, for example stainless steel or a nickel-titanium alloy. The cutting edges may be formed by torsioning, cutting, grinding, machining, laser micromachining, or grit blasting. | 2008-09-04 |
| 20080213721 | Device For Protecting the Head of a Dental Handpiece and Sealed Packaging For an Insert Equipped With Said Device - The invention relates to a protective device for dental equipment of the type composed mainly of a straight handpiece ( | 2008-09-04 |
| 20080213722 | Handpiece With Coating For Moved or Movable Parts - A handpiece, in particular for medical, dental-medical or dental-technical purposes, has a drive mechanism for a tool to be held by the handpiece, wherein moving or movable parts of the handpiece are provided at least partly with a coating, which is chromium nitride and/or titanium nitride+gold. | 2008-09-04 |
| 20080213723 | Medical/dental handpiece - An inventive medical/dental handpiece is characterized by including: a head part | 2008-09-04 |
| 20080213724 | Kit For Repairing, Supplementing And Relining Dental Prostheses In A Dentist's Practice - Dental prosthesis repair kit, including a light-curing dental prosthesis repair material, a diamond grinder for the end of a dentist's tool holder, and a bonding agent solution. | 2008-09-04 |
| 20080213725 | Method and Arrangement for a Dental Installation - A substrate has or is provided on a surface with a first porosity. A dispersion with low-viscosity liquid is applied to the surface in order to form a ceramic layer with a second porosity having preferably larger and/or more pores than in the first porosity. The liquid has the ability to be sucked by capillary force into the first pore formation and, in a first stage, to retain on the surface material and/or liquid particles which do not penetrate into this first pore formation, and which contribute to the continued construction of the layer. In a second stage, the substrate is subjected to sintering in which the particles finally forming the layer are held together with intermediate spaces which consist of or are included in the second porosity, the spaces being formed either by the fact that material and liquid particles separate from the particles finally forming the layer are driven off during the sintering and/or by the fact that the particles forming the layer are chosen with a particle size which means that the last-mentioned particles are held together after the sintering despite the intermediate spaces. The invention also relates to an arrangement. By means of the invention, a dental product can be provided with excellent porosity which is advantageous in connection with dental installations. | 2008-09-04 |
| 20080213726 | Dental Implant and Method for the Production Thereof - The invention relates to a ceramic implant, especially a dental implant, comprising a structured or porous surface for at least partially inserting into a bone. An especially advantageous surface is obtained when it is at least partially modified by a salt melt. These excellent osteointegration properties can be obtained by a method whereby the surface is modified in a salt melt at least in the regions exposed to the bones and/or soft tissue, optionally following a previous modification of the surface whereby material has been removed. | 2008-09-04 |
| 20080213727 | Graded glass/ceramic/glass structures for damage resistant ceramic dental and orthopedic prostheses - The present invention provides a functionally graded glass/ceramic/glass sandwich system especially useful in damage resistant, ceramic dental and orthopedic prosthesis. The functionally graded glass/substrate/glass composite structure comprises an outer (aesthetic) residual glass layer, a graded glass-ceramic layer, and a dense interior ceramic. The functionally graded glass/substrate/glass composite structure may further comprise a veneer on an exterior surface. The present invention also provides a method for preparing a functionally graded glass/ceramic/glass sandwich system. A powdered glass-ceramic composition or a glass tape is applied to the accessible surfaces of a dense alumina substrate to thereby substantially cover the substrate surfaces. The glass of the composition has a CTE similar to that of the substrate material. The glass-ceramic composition is infiltrated into the dense substrate by heating the assembly to temperatures 50-700° C. below the sintering temperature of the substrate. | 2008-09-04 |
| 20080213728 | Dental Implant Fixture - The present invention provides a fixture for a dental implant that serves as a replacement for a missing tooth and is implanted in the maxillary or mandibular bone. In this fixture invention the R/S border (the border between the rough and smooth surfaces) is formed to be inclined to a plane perpendicular to the long axis (central axis) of the dental implant fixture. The dental implant fixture prevents a marked decrease in the support for the dental implant due to bone reduction procedure in a patient having inclined bone crest, eliminates disadvantages in the aspects of expenses caused by the application of guided bone regeneration technique and also removes inconvenience of long operation time and possible infection, and also has a remarkable advantage of making convenient one-staged surgery possible in many cases. | 2008-09-04 |
| 20080213729 | METHOD AND APPARATUS FOR PERFORMING MAXILLARY SINUS ELEVATION - A method and apparatus is disclosed for providing implants in the upper jaws of a person. A sleeve is inserted through the alveolar ridge to the maxillary sinus. The sleeve is used to raise the subantral membrane and form a cavity. A filler, such as a bone growth stimulant is injected through the sleeve into the cavity. In the process, the sleeve also can cut and/or condense the bone around itself so that the bone can hold an implant. Optionally, the bone growth stimulant is also introduced into the bone surrounding the sleeve. During the injection, the pressure within the sleeve or the cavity is monitored to detect and prevent the rupture of the subantral membrane. | 2008-09-04 |
| 20080213730 | TOOTH WHITENING DENTAL TRAY AND METHOD OF USE - A dental tray with a hydrophobic tooth whitening formulation where the tooth whitening formulation is substantially non-water soluble, and a method of using this dental tray to whiten the teeth. The tooth whitening formulation is primarily comprised of a hydrophobic polymer and a peroxide or a peroxide yielding compound. Preferably the hydrophobic polymer is the condensation product of a silicone resin and an organosiloxane. The dental tray is formed to encompass the front and the rear surfaces of the teeth. The dental tray is comprised of a thermoplastic or thermoset polymer. The teeth whitening formulation is placed into the dental tray and the tray placed against the teeth to be whitened. This is for a sufficient period of time to at least partially whiten teeth. This can be a period of time from about 0.5 hour to 2 hours or more. The substantially non-aqueous tooth whitening formulation is effective over a longer period of time since it is not significantly diluted or removed from the dental tray during the treatment time. | 2008-09-04 |
| 20080213731 | DEVICES AND METHODS OF APPLYING DENTAL COMPOSITES - A device and method for applying dental composite matter to dental surfaces, such as cavities in teeth, gaps in teeth, or other deformations in tooth surfaces, or other applications to teeth, or appliances and devices used with teeth, such as crowns or inlays/onlays. A hand held powered tool provides oscillation of the composite material after the composite material is grossly applied to the dental surface. The oscillation is at a frequency and amplitude that facilitates uniform spreading of the composite material over the dental surface in a desired pattern, while retarding the tendency of the material to stick to the tool. | 2008-09-04 |
| 20080213732 | System and Method for Calculating a Projectile Impact Coordinates - A training system and method to calculate actual coordinates of a projectile impact at one or more screens has been disclosed. A projectile is launched at a screen. One or more targets are projected onto the screen. A calibrated sensor is directed at the screen surface. The sensor continually captures thermal images of a screen surface. The sensor comprises software to detect and isolate thermal images of the projectile impacting the screen. These impact images are transmitted to a computer connected to the sensor. A computer comprises software to calculate the actual impact coordinates relative to a projected target. The calculated coordinates are digitally sent to feedback devices for display purposes. The system further comprises virtual training scenarios that are triggered upon notification of actual impact coordinates. These training scenarios simulate real life situations. | 2008-09-04 |
| 20080213733 | Dieter's reality check garbage can - The dieter's reality check garbage can is made of plastic and is a miniature replica of a galvanized residential trash can. The contents inlude artifical foods made of plastic or rubber (pizza, donuts, soda, french fries, cake, candy bars). A tote bag made of canvas. | 2008-09-04 |
| 20080213734 | Method for Decoding Pictographic Signs Present on Ancient Artifacts - The invention is a method for transcribing and decoding/reading pictographic characters found on ancient artifacts, dated either prior, during or after the time of the beginnings of Dynastic Ancient Egypt (circa 3100 BC), in such a way, so that they may be presented in schematic drawings (sets of pictographic signs) for which analogues are found in Hieroglyphic Inscriptions, following the stylized version of the pictographic script from the pyramid texts of Ancient Egypt, independent of the calligraphic styles applied. Thus transcribed in the form and shape of Egyptian Hieroglyphs, these characters are then translated into modern languages, using the scientifically accepted systems for reading the Egyptian hieroglyphic script. | 2008-09-04 |
| 20080213735 | MANIPULATIVE OBJECT WITH ADHESIVE BACKING - An educational device having a two-dimensional setting having a smooth surface and at least one three-dimensional manipulative figure and/or object comprising a front side that is | 2008-09-04 |
| 20080213736 | METHOD AND APPARATUS FOR EMOTIONAL PROFILING - A method for emotional profiling comprises: obtaining, from plural respondents, non-verbal emotional response data, along with verbal responses; grouping the verbal responses according to the non-verbal emotional response data; and reporting the verbal and/or text-based responses by group. An apparatus for emotional profiling comprises: means for obtaining quantitative and/or qualitative emotional response data, along with verbal and/or text-based responses from participants; means for grouping response data and responses according to the quantitative and/or qualitative data; and means for reporting the verbal and/or text-based responses by group. | 2008-09-04 |
| 20080213737 | Enclosed Vapor Pressure Oscillation Device - A mechanical toy having two enclosed chambers, one positioned above the other, connected by a tube; a vaporizing medium contained within the enclosed chambers and tube; means for rotationally supporting the tube and chambers; means for exciting the vaporizing medium within the lower chamber to create an increase in vapor pressure within the lower chamber relative to the upper chamber that exerts force upon the vaporizing medium within the lower chamber to communicate the vaporizing medium through the tube into the upper chamber allowing gravity to act upon the upper chamber when a sufficient amount of the vaporizing medium has collected within the upper chamber pulling the upper chamber downward around the means of rotational support. | 2008-09-04 |
| 20080213738 | Electronic Circuit Experiment Board - The present invention is an electronic circuit experiment board, which is composed of an insulated base plate, copper binding posts and a bracket and so on. The base plate is divided into an upper plate and a lower plate, which have binding post inserting holes and circlips. The binding posts can be inserted into the binding post inserting holes and then be fastened by the circlips. There are a binding hole and a screw hole on the ends of the binding posts respectively. The binding post also includes a screw lever cooperated with the screw hole, a positioning groove and a positioning ring. The experiment board has the advantages of good contact performance, convenient to use, high experimental efficiency, long service life and strong ability of splicing and dilatancy, arranging elements in double sides, and multilayer wiring in electronic circuit. | 2008-09-04 |
| 20080213739 | School-level outcome standard setting method - A standard setting method for schools including establishing a student level standard, generating a school-level standard based on a percentage of students that meet the student-level standard for performance criteria, and generating a report. | 2008-09-04 |
| 20080213740 | System and Method for Creating, Executing and Searching through a form of Active Web-Based Content - Xml pages are obtained from knowledge bases that contain step by step instructions. The xml pages are presented as “active content,” by which we mean a series of prompted questions and answers. A user's interactions with the active content is recorded so that the results may be copied to the user's clipboard for automatic transfer to a problem management/ticketing system. Active content that contains embedded questions asked of the user may be used to infer answers to some of the questions from a search query, and, thus, alleviate the need for the user to answer them. | 2008-09-04 |
| 20080213741 | DISTRIBUTED LEARNING PLATFORM SYSTEM - A system for distributing educational information includes compiling educational information from educational sources. The user connects to a management system through a network connection. A user account may be authenticated with a user identification. The management system then transmits a plurality of educational material that may be used and operated on the user's computer when the user is offline. Later, the management system performs a sync operation when the user is able to reconnect to the system. | 2008-09-04 |
| 20080213742 | HIGH SURFACE CULTIVATION SYSTEM - An exemplary embodiment of a reversibly closable vessel suitable for the cultivation of cells and/or tissues can be provided. The exemplary vessel can comprise at least one reversibly closable aperture in the vessel wall, a convection arrangement inside the vessel which can comprise at least one blade. The arrangement can be configured to generate and/or modulate a convection in a fluid within the vessel when the vessel and/or the blade is agitated The convection arrangement and/or the blade can be at least particularly made from a porous material. | 2008-09-04 |
| 20080213743 | Method for adjusting sedimentation rates - One or more chemicals are added to a physiological fluid to alter the density and/or shape of cells in the fluid to provide a desired sedimentation rate of the cells. In a preferred embodiment, the chemical to be added is an anticoagulant, preferably ACD. | 2008-09-04 |
| 20080213744 | Method of Determining Hypoxia - A method of determining hypoxia in fetal scalp blood sampled during labor comprises the determination of total lactate dehydrogenase (LDH) in plasma obtained from the sample. The method can comprise the additional determination of K, Mg, Ca, AST, ALT, lactate in the plasma and/or blood. Increased values of one or more of LDH, Mg, Ca, AST, ALT, lactate are indicative of hypoxia in the fetus. Also disclosed is the use of a plasma separation apparatus in the method. | 2008-09-04 |
| 20080213745 | Biomarkers Of Metabolic Responses To Hepatotoxicants And Carcinogens - Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring of drug efficacy. | 2008-09-04 |
| 20080213746 | Methods of Diagnosis and Risk Stratification of Adverse Events in Post Myocardial Infarction Patients Using Pro-adrenomedullin - The invention provides methods for the diagnosis and risk stratification of adverse events in post-myocardial infarction patients by means of proADM, whereby a determination of the marker pro-adrenomedullin or partial sequence or a fragment thereof or contained in a marker combination (panel, cluster) is carried out on a post-myocardial infarction patient. The invention also provides a diagnostic device and a kit for the performance of the method of the method of the invention. | 2008-09-04 |
| 20080213747 | FLUORESCENT POLYMER SUPERQUENCHING-BASED BIOASSAYS - A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering element, and (c) a property-altering element is disclosed. Both the fluorescent polymer and the receptor are co-located on a support. When the chemical moiety is bound to the receptor, the property-altering element is sufficiently close to the fluorescent polymer to alter the fluorescence emitted by the polymer. When an analyte sample is introduced, the target biological agent, if present, binds to the receptor, thereby displacing the chemical moiety from the receptor, resulting in an increase of detected fluorescence. Assays for detecting the presence of a target biological agent are also disclosed. | 2008-09-04 |
| 20080213748 | Method for Detection and Analysis of Macromolecular Complexes - The present invention relates to a method for the detection and/or analysis of the structure of macromolecular complexes and/or macromolecules comprising the steps of (a) purifying or separating said macromolecular complexes and/or macromolecules from a sample containing said macromolecular complexes and/or macromolecules by applying in a porous matrix a separation force in a first dimension (X-axis); (b) transferring in a second dimension (Z-axis) by adsorption forces the macromolecular complexes and/or macromolecules purified or separated in step (a) from the porous matrix onto a carrier wherein said carrier contacts the surface of the porous matrix and is positioned parallel to the surface of said matrix and parallel to the direction of the separation force applied in step (a); (c) immobilizing the macromolecular complexes and/or macromolecules on said carrier after transfer of step (b); and (d) assessing the structure of the macromolecular complexes and/or macromolecules on said carrier after immobilization of step (c). | 2008-09-04 |
| 20080213749 | Compositions and methods for detecting human metapneumovirus - Disclosed are oligonucleotides useful in methods for determining whether a sample contains a human metapneumovirus or has an increased likelihood of containing a human metapneumovirus, a virus which is a causative agent of respiratory tract disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fusion protein of a human metapneumovirus, are useful as forward and reverse primers for a polymerase chain reaction using reverse transcripts of RNA from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains a human metapneumovirus or has an increased likelihood of containing a human metapneumovirus. | 2008-09-04 |
| 20080213750 | HCV Variants and Related Methods - HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive subpassage greater than HCV that have wild-type polyprotein coding regions. Expression vectors comprising the above polynucleotides and HCV variants are also described, as are the provision of cells and host cells comprising the expression vectors. Methods for identifying a cell line that is permissive for infection with HCV are also provided, as are vaccines comprising the above polynucleotides in a pharmaceutically acceptable carrier. Additionally, methods for inducing immunoprotection to HCV in a primate are described, as are methods for testing a compound for inhibiting HCV replication. | 2008-09-04 |
| 20080213751 | ILCS BASED PATTERN RECOGNITION OF SEPSIS - The present invention refers to a method for recognizing and/or characterizing cellular activity patterns, in particular for diagnostic purposes and/or for tracking the therapy of diseases. Blood cells are stimulated in a culture medium at least with toll-like receptor ligands (TLR ligands) and the stimulated blood cells and/or the culture medium are examined. | 2008-09-04 |
| 20080213752 | Bacteriophages as Selective Agents - Compositions containing bacteriophages and methods of using bacteriophages in microorganism detection assays and microbial growth and plating media are disclosed. The lytic ability of these phages to control the growth of non-target populations provides superior sensitivity and specificity to detection assays and reduces false negative and false positive results. The removal of contaminating bacteria reduces the microbial competition for nutrients in the growth media thereby increasing the efficiency and productivity of the culture. The phage treatment of the sample increases the proportion of target microorganisms in the sample over contaminating bacteria thereby requiring less time for enrichment to obtain a significant signal improving overall signal to noise ratio in assays and providing for higher yield of end product in microbiological production systems. | 2008-09-04 |
| 20080213753 | METHOD FOR THE VERIFICATION OF THE REMOVAL OF VIRUSES TO VALIDATE FILTERS AND FILTERING PROCESSES - Disclosed is a method for verification of the removal of viruses to validate filters, filtering processes, physical and chemical inactivation processes, or adsorptive removal processes in predefined process conditions that are simulated on a small scale. According to said method, viruses are cultured in suitable cell lines in a first step, a virus suspension is obtained after solubilizing cells in a second step, the virus suspension obtained is added in a third step to a protein solution that is to be analyzed, and the virus-containing protein solution is filtered through the filter that is to be validated, and the removal of viruses is then analyzed in a fourth step. The virus suspension is first processed via a membrane adsorber following step two, the viruses being bonded to the membrane adsorber and contaminants being removed with the aid of a detergent buffer solution, while the bonded, purified viruses are eluted from the membrane adsorber area and are added to the protein solution that is to be analyzed as a concentrated virus suspension in step three. | 2008-09-04 |
| 20080213754 | Method of Amplifying Atp and Use Thereof - The ATP amplification method of the present invention is a method for amplifying and detecting a very trace amount of exogenous ATP by allowing a fusion protein (PPK-ADK) of a polyphosphate kinase and an adenylate kinase, the fusion protein not containing ADP, to act on a mixture of ATP, AMP, and a polyphosphate compound. The present invention also provides an ultrasensitive ATP amplification method by which ATP at a single cell level can be amplified and detected, and an ultrasensitive microbial assay based on this ATP amplification method. | 2008-09-04 |
| 20080213755 | Method and Device for Detection of Nucleic Acid Sequences | 2008-09-04 |
| 20080213756 | Real-Time Pcr Point Mutation Assays For Detecting Hiv - 1 Resistance to Antiviral Drugs - Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID NOS:1-89, and 96-104. Also provided are the oligonucleotides consisting of the nucleotides as set forth in SEQ ID NOS: 1-89, and 96-104. Each of the disclosed oligonucleotides is a probe or a primer. Also provided are mixtures of primers and probes and for use in RT-PCR and primary PCR reactions disclosed herein. Provided are methods for the specific detection of several mutations in HIV. Mutations in both the reverse transcriptase and the protease of HIV can be detected using the methods described herein. | 2008-09-04 |
| 20080213757 | Methods of Distinguishing Types of Spinal Neurons Using Corl1 Gene as an Indicator - As a result of screening for genes that are selectively expressed in fetal mouse brain region by subtraction method, the present inventors obtained a cDNA fragment encoding Corl1. The expression of Corl1 was examined by RT-PCR, in situ hybridization, and immunostaining using polyclonal antibodies. The results demonstrated that Corl1 was especially expressed at a high level of selectively in the central nervous system during embryonic stages. The expression patterns of Corl1 determined using various markers in embryonic spinal cord were compared to identify types of neurons expressing Corl1. The results revealed that Corl1 was specifically expressed in spinal cord interneurons dI4, dI5, dILA, and dILB. Accordingly, the present invention provides for discrimination between dI4 and dI6, neurons which previously could only be discriminated based on developmental location, using the expression of Corl1 as an indicator. | 2008-09-04 |
| 20080213758 | Method For Estimating End Use Qualities of Wheat at Growth Stage - The invention provides a means for estimating the end use qualities of wheat flour that will be obtained in the future from the harvested wheat at an early stage before maturation of the wheat seeds. The invention relates to a method for estimating the end use qualities of a matured wheat seed, comprising measuring the expression level of at least 1 gene selected from genes, each of which is defined by any one of the nucleotide sequences of SEQ ID NOS: 1 to 121 in immature wheat. | 2008-09-04 |
| 20080213759 | Novel Angiogenesis Inhibitor - Because AK022567 has angiogenesis inhibitory activity, it is useful as an angiogenesis inhibitor. Furthermore, 4 splicing variants obtained from the same gene are also useful as an angiogenesis inhibitor. These 5 polypeptides, polynucleotides encoding the polypeptides and antibodies against the polypeptides are useful for screening of a candidate compound as an angiogenesis inhibitor or promoter. A compound obtained from the screening is useful as a medicine and can be used for a preventive or therapeutic agent for an angiogenesis related disease. | 2008-09-04 |
| 20080213760 | COMPOSITIONS AND METHODS FOR PROTEIN ISOLATION - The invention provides for polynucleotides and vectors comprising at least two tag sequences. The invention also provides for polynucleotides and vectors comprising a streptavidin binding peptide sequence and a calmodulin binding peptide sequence. The invention also provides for polynucleotides and vectors wherein a gene of interest is fused in frame to at least two tag sequences, for example, a streptavidin binding peptide sequence and a calmodulin binding peptide sequence. The invention also provides for the chimeric proteins encoded by these polynucleotides. The invention also provides for methods of using the polynucleotides of the invention for detecting and/isolating protein complexes or identifying a binding partner for a protein of interest. | 2008-09-04 |
| 20080213761 | Agonists of Bitter Taste Receptors and Uses Thereof - The present invention relates to agonists of the hTAS2R1, hTAS2R3, hTAS2R7 and hTAS2R40 bitter taste receptors, respectively, and their role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block hTAS2R1, hTAS2R3, hTAS2R7 or hTAS2R40 bitter taste transduction or bitter taste response. | 2008-09-04 |
| 20080213762 | Method of Gene Sequence Examination - The present invention provides a method for detecting quantitatively a specific nucleic acid sequence and for detecting gene polymorphism or mutation by homogenous system simply, promptly, accurately, and inexpensively, and an oligonucleotide probe used therefor. The nucleic acid having a specific sequence is quantitatively detected and gene polymorphism or mutation is detected in such a way that a probe DNA containing one or two labeling materials is hybridized to the target nucleic acid, and decomposed from the 5′- or the 3′-terminal by exonuclease action to release one of the labeling materials, the signal emitted by which is then detected. | 2008-09-04 |
| 20080213763 | Human Protooncogene and Protein Encoded by Same, and Expression Vector Containing Same - Disclosed are a novel protooncogene and a protein encoded by same. The protooncogene of the present invention is a novel gene, and may be effectively used for diagnosing the cancers, including leukemia, uterine cancer, lymphoma, colon cancer, lung cancer, skin cancer, etc., as well as producing transformed animals, etc. | 2008-09-04 |
| 20080213764 | Human Protooncogene and Protein Encoded Therein - Disclosed are a novel protooncogene and a protein encoded therein. The protooncogene of the present invention, which is a novel gene that takes part in human carcinogenesis and simultaneously has an ability to induce cancer metastasis, may be effectively used for diagnosing the cancers, including lung cancer, leukemia, uterine cancer, lymphoma, colon cancer, skin cancer, etc., as well as producing transformed animals, etc. | 2008-09-04 |
| 20080213765 | Human Autism Susceptibility Genes Encoding a Neurotransmitter Transporter and Uses Thereof - The present invention discloses the identification of a human autism susceptibility gene, which can be used for the diagnosis, prevention and treatment of autism and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the SLC6A1 or SLC6A11 gene on chromosome 3 and certain alleles thereof are related to susceptibility to autism and represent novel targets for therapeutic intervention. The present invention relates to particular mutations in the SLC6A1 or SLC6A11 gene and expression products, as well as to diagnostic tools and kits based on these mutations. The invention can be used in the diagnosis of predisposition to, detection, prevention and/or treatment of Asperger syndrome, pervasive developmental disorder, childhood disintegrative disorder, mental retardation, anxiety, depression, attention deficit hyperactivity disorders, speech delay, epilepsy, metabolic disorder, immune disorder, bipolar disease and other psychiatric and neurological diseases including schizophrenia. | 2008-09-04 |
| 20080213766 | METHOD AND DEVICE FOR DETECTING THE PRESENCE OF A SINGLE TARGET NUCLEIC ACID IN SAMPLES - A method comprising for each individual sample of a plurality of samples, loading at least one sample portion of the individual sample into at least one respective sample chamber of a plurality of sample chambers, subjecting the sample portions to at least a first amplification step; and then determining whether sample portions contain at least one molecule of the target nucleic acid. For each sample portion, if the sample portion contains at least a single molecule of the target nucleic acid, the sample portion would attain a detectable concentration of the target nucleic acid after a single round of amplification. | 2008-09-04 |
| 20080213767 | Detection Of Nucleic Acids By Target-Catalyzed Product Formation - A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide, for example, a polynucleotide analyte, in the presence of a 5′-nuclease under isothermal conditions. The polynucleotide analyte serves as a recognition element to enable a 5′-nuclease to cleave the oligonucleotide to provide (i) a first fragment that is substantially non-hybridizable to the polynucleotide analyte and (ii) a second fragment that lies 3′ of the first fragment (in the intact oligonucleotide) and is substantially hybridizable to the polynucleotide analyte. At least a 100-fold molar excess of the first fragment and/or the second fragment are obtained relative to the molar amount of the polynucleotide analyte. The presence of the first fragment and/or the second fragment is detected, the presence thereof indicating the presence of the polynucleotide analyte. The method has particular application to the detection of a polynucleotide analyte such as DNA. Kits for conducting methods in accordance with the present invention are also disclosed. | 2008-09-04 |
| 20080213768 | Identification and use of biomarkers for non-invasive and early detection of liver injury - The present invention provides methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of disease and/or toxicity, disease staging, target identification/validation, and monitoring of drug efficacy/toxicity. The present invention further provides suites of small molecule entities as biomarkers for non-invasive and early prediction of hepatic injury. | 2008-09-04 |
| 20080213769 | Automated Method for Detecting Cancers and High Grade Hyperplasias - Automated methods for detecting cancer and related hyperplasias in biological samples. | 2008-09-04 |
| 20080213770 | Method of Determining The Nucleotide Sequence of Oligonucleotides and DNA Molecules - The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions. | 2008-09-04 |
| 20080213771 | Methods and Compositions for Large-Scale Analysis of Nucleic Acids Using DNA Deletions - The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. The invention provides methods, compositions and systems for such analysis. Encompassed by the invention are constructs that include pairs of target sequences which are separated by a known distance in the polynucleotide from which they are derived. | 2008-09-04 |
| 20080213772 | USE OF MICROPHTHALMIA FOR DIAGNOSIS, PROGNOSIS AND/OR TREATMENT OF MELANOMA - Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be diagnosed by contacting a malignant cell with a probe for Mi. If the probe identities Mi in the nucleus of the cell, the cell is a melanoma. | 2008-09-04 |
| 20080213773 | Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing - A method for identifying an RNA form of a bacteria, comprising reverse transcribing RNA material; conducting PCR using primers for a first highly conserved genetic sequence generic of the bacteria; conducting nested PCR using primers for a second highly conserved genetic sequence within the first genetic sequence of the bacteria; and identifying the bacteria based on unconserved amplified sequences linked to the conserved sequences. | 2008-09-04 |
| 20080213774 | Mutations in Kit Confer Imatinib Resistance in Gastrointestinal Stromal Tumors - The present invention relates to methods and compositions concerning resistance to a drug for cancer comprising aberrant KIT signal, such as aberrant KIT sequence or expression. In a specific embodiment, the cancer is also initially responsive to imatinib therapy, such as in gastrointestinal stromal tumors (GISTs). In particular embodiments, a mutation in a KIT polynucleotide confers resistance to imatinib treatment, and in specific embodiments the exemplary mutation is at 1982T→C. Thus, the invention provides a means to adjust for or circumvent the resistance to imatinib drug treatment. | 2008-09-04 |
| 20080213775 | METHODS AND MATERIALS FOR IDENTIFYING POLYMORPHIC VARIANTS, DIAGNOSING SUSCEPTIBILITIES, AND TREATING DISEASE - The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTBFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications. | 2008-09-04 |
| 20080213776 | METHOD FOR TREATING AUTOIMMUNE DISEASES AND SCREENING METHOD FOR PREVENTIVE OR THERAPEUTIC AGENT FOR THE SAME - The present invention is directed to a method for treating autoimmune diseases comprising administering RBAp48 production suppressor or inhibitor; a screening method for a preventive or therapeutic agent for autoimmune diseases comprising determining RBAp48 production suppressing effect or inhibitory effect of a sample; a diagnosis agent or a diagnosing kit for autoimmune diseases containing a reagent for measuring RBAp48 level in gland tissue; and a diagnosis method for autoimmune diseases comprising measuring RBAp48 level in gland tissue. | 2008-09-04 |
| 20080213777 | Tumor suppressor pathway in C. elegans - The invention provides novel lin-8, lin-56, and lin-61 genes and polypeptides involved in cell fate determination and in cell proliferation. In addition, the invention includes mutants of these three genes, as well as methods for utilizing these genes, and their encoded polypeptides, in diagnosing and treating abnormal cell proliferation. | 2008-09-04 |
| 20080213778 | Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses - The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 2008-09-04 |
| 20080213779 | Nalp7-Based Diagnosis of Female Reproductive Conditions - Methods, reagents and kits are described for the diagnosis of a female reproductive condition, based on the detection of an alteration in a NALP7-encoding nucleic acid or a NALP7 polypeptide, relative to a corresponding wild-type NALP7-encoding nucleic acid or NALP7 polypeptide. | 2008-09-04 |
| 20080213780 | MULTI-COLOR TIME RESOLVED FLUOROPHORES BASED ON MACROCYCLIC LANTHANIDE COMPLEXES - The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands. | 2008-09-04 |
| 20080213781 | Methods of detecting methylation patterns within a CpG island - A method of increasing sensitivity of a DNA methylation assay by determining complementation within a CpG island of the methylated DNA. | 2008-09-04 |
| 20080213782 | SOCS-1 Gene Methylation in Cancer - Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription of SOCS/CIS gene such as a SOCS-1 gene, are provided, as are reagents for practicing such methods. | 2008-09-04 |
| 20080213783 | SITE-SPECIFIC ENZYMATIC DEPOSITION OF METAL IN SITU - The present invention provides compositions, kits, assembles of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention relates to use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also relates to linking of metals to enzyme substrates, control of enzymatic metal deposition and applications of enzymatic metal deposition to sensitively and selectively detect target molecules such as biomarkers in various biological samples, such as chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope. | 2008-09-04 |
| 20080213784 | SCREENING METHODS AND SEQUENCES RELATING THERETO - A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of:
| 2008-09-04 |
| 20080213785 | Method of predicting a benefit of antioxidant therapy for prevention or treatment of vasclar disease in hyperglycemic individuals - This invention relates to methods and compositions of determining the benefit of therapy using antioxidant for the treatment of cardiovascular events in individuals with diabetes mellitus based on their haptoglobin phenotype and the treatment of the cardiovascular events using antioxidants based on the haptoglobin phenotype. | 2008-09-04 |
| 20080213786 | Treatment of rheumatoid arthritis with galectin-3 antagonists - The invention encompasses a novel method of treating an inflammatory disease, such as rheumatoid arthritis, and novel methods of identifying and screening for drugs useful in the treatment of inflammatory diseases, such as rheumatoid arthritis, and their clinical symptoms. The inventors have made the discovery that the activity of galectin-3, a β-galactoside-binding lectin known to have an effect on some cancers, has a significant impact on the pathophysiology of rheumatoid arthritis. The symptoms of an inflammatory disease, such as rheumatoid arthritis, may be alleviated by administering a compound that inhibits the activity of galectin-3. | 2008-09-04 |
| 20080213787 | Methods and Compositions for Kir Genotyping - The present invention provides methods for single nucleotide polymorphism (SNP)-based killer cell immunoglobulin-like receptor (KIR) gene cluster genotyping using the matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer. In general, the methods involve amplifying a plurality of target sequences of a plurality of KIR genes, and detecting the presence or absence of a plurality of single SNPs of the plurality of KIR genes by MALDI-TOF mass spectrometry. The invention also features compositions, including arrays of capture primers and optionally extension primers on a substrate surface, and kits, for use in the methods of the invention. | 2008-09-04 |
| 20080213788 | GENE CODING FOR SCYTALONE DEHYDRATASE EXHIBITING RESISTANCE TO AGRICULTURAL FUNGICIDAL AGENT - The present invention provides a gene that can be used extensively in studies relating to resistant rice blast fungi. | 2008-09-04 |
| 20080213789 | Assay for detecting methylation status by methylation specific primer extension (MSPE) - The present invention relates to detecting the relative methylation levels at one or more CpG sites on a nucleic acid molecule, by using the methylation specific primer extension reaction (MSPE). MSPE uses an agent to modify unmethylated cytosine at a CpG site to uracil and subsequently amplify the chemically treated nucleic acids. The MSPE primers distinguishing between unmethylated and methylated CpG sites are provided to conduct MSPE. Relative methylation levels at one or more CpG sites are performed by detecting the signal intensity of labels incorporated into the MSPE reaction products. | 2008-09-04 |
| 20080213790 | METHOD FOR SYNTHESIZING POLYNUCLEOTIDES - The present invention realized isothermal and rapid polynucleotide synthesis by using as templates polynucleotides having a structure capable of forming loops, and combining a plurality of primers capable of providing a starting point for complementary strand synthesis to such loops. If the LAMP method is applied, all reactions can be carried out isothermally and rapidly since the template polynucleotides themselves can also be synthesized by an isothermal reaction. | 2008-09-04 |
| 20080213791 | Materials and methods for assaying for methylation of CpG islands associated with genes in the evaluation of cancer - Provided are methods, reagents, and kits for evaluating cancer, such as prostate cancer, in a subject. Disclosed methods of evaluating cancer include methods of diagnosing cancer, methods of prognosticating cancer and methods of assessing the efficacy of cancer treatment. The methods include assaying a biological sample for methylation of a CpG island associated with specified genes. Provided reagents and kits include primers suitable for amplifying at least a portion of a target CpG islands associated with specified genes. | 2008-09-04 |
| 20080213792 | Homogeneous Multiplex Screening Kits - Kits for highly multiplexed homogeneous in vitro screening assays for numerous possible nucleic acid targets, any of which might be present in a sample, that utilize fluorescent hybridization probes that are combinatorially coded from a panel of fluorophores by subdividing each probe into portions and differently labeling each portion such that, when portions are combined, each probe has a unique code. The kits may include reagents and primers for target amplification and real-time detection. | 2008-09-04 |
| 20080213793 | ANTIBODIES THAT BIND RECEPTOR PROTEIN DESIGNATED 2F1 - 2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation. | 2008-09-04 |
| 20080213794 | SCREENING FOR GESTATIONAL DISORDERS - The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy. | 2008-09-04 |
| 20080213795 | DNA sequences encoding peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes - The invention discloses isolated DNA sequences encoded by polypeptides characterized by the presence in their structure of one or more sequences bearing all or part of the one or more T epitopes, and possibly other epitopes, particularly B epitopes, characteristic of proteins resulting from the infectious activity of | 2008-09-04 |
| 20080213796 | GFP-SNAP25 Fluorescence Release Assay for Botulinum Toxin Protease Activity - The present invention provides a nucleic acid molecule which contains a nucleotide sequence encoding a SNAP-25 substrate which includes (i) a green fluorescent protein; (ii) a first partner of an affinity couple; and (iii) a portion of SNAP-25 that includes a BoNT/A, BoNT/C1 or BoNT/E recognition sequence containing a cleavage site, where the cleavage site intervenes between the green fluorescent protein and the first partner of the affinity couple. Further provided herein is a nucleic acid molecule which contains a nucleotide sequence encoding a tagged toxin substrate which includes (i) a fluorescent protein; (ii) a first partner of an affinity couple; and (iii) a clostridial toxin recognition sequence containing a cleavage site, where the cleavage site intervenes between the fluorescent protein and the first partner of the affinity couple. | 2008-09-04 |
| 20080213797 | IMMUNOASSAYS EXHIBITING A REDUCTION IN PROZONE PHENOMENA - The present invention relates to immunoassays for detecting or quantifying at least one analyte of interest in a test sample. Specifically, the immunoassays of the present invention exhibit a reduction in prozone phenomena. | 2008-09-04 |
| 20080213798 | NOVEL C. ELEGANS P21-ACTIVATED KINASE (PAK) GENE AND ASSOCIATED LOSS-OF-FUNCTION PHENOTYPES THAT FACILITATE SCREENING FOR SMALL MOLECULE MODULATORS OF PAK ACTIVITY IN THE NEMATODE, CAENORHABDITIS ELEGANS - The invention refers to a novel | 2008-09-04 |
| 20080213799 | Method for Detection of Substance Bound to Nuclear Receptor - Provided is a detection method including exposing, to contact with a surface to which a cofactor has been bound, a nuclear receptor protein serving as a counterpart of the cofactor and a test sample; and detecting a substance which is contained in the test sample and which binds to the nuclear receptor, on the basis of a change in degree of binding between the nuclear receptor protein and the cofactor. The detection method is means for detecting a living-body-related substance, which means employs a nuclear receptor-cofactor system, exhibits detection high sensitivity, provides a convenient detection process, and realizes efficient establishment of a detection system. | 2008-09-04 |
| 20080213800 | Method for Examing Interstitital Cystitis - It has been found that the urine from an IC patient shows a high value in amount and the existence of activity of an azurophilic granular substance, thereby to establish a method for examining IC. The present invention relates to a method for examining interstitial cystitis using the kinetics of an azurophilic granular substance in urine as a marker. Also, the present invention relates to a kit for examining interstitial cystitis for use in the examination method, a use of an azurophilic granular substance as a test marker for examining interstitial cystitis or evaluating pharmacological effects of a drug, and a method for examining therapeutic effects on a patient with interstitial cystitis using an azurophilic granular substance as a marker. | 2008-09-04 |
| 20080213801 | Monomeric streptavidin muteins - The invention includes a streptavidin mutein having at least one mutation chosen to cause one or more of steric hindrance, charge repulsion, or improvement of solubility by changing interfacial hydrophobic residues to less hydrophobic or hydrophilic residues. The mutein may exist in monomeric form even in the presence of biotin, and reversibly binds to biotin. The invention also includes polynucleotides encoding such muteins, expression systems and host cells for producing such muteins. The invention also includes a method of capturing biotinylated molecules using the muteins of the invention. | 2008-09-04 |
| 20080213802 | Diagnosis of Neurodegenerative Diseases - The invention relates to a method of diagnosis of vCJD in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being: beta-actin (SwissProt Ace. No. P60709), apolipoprotein A-IV precursor (SwissProt Acc. No. P06727); haptoglobin beta-chain consisting of residues 162-406 (SwissProt Acc. No. P00738); haemoglobin beta chain (SwissProt Ace. No. P02023); or alpha-1-antitrypsin (SwissProt Ace. No. P01009); or a decreased concentration of a protein in the diagnostic sample, compared with a sample of a control, normal human subject, the protein being plasma protease (C1) inhibitor precursor (SwissProt Acc. No. P05155); complement component 1, s sub-component (SwissProt Acc. No. P09871); butyrylcholinesterase precursor (SwissProt Acc. No. P06276); complement component C4B (SwissProt Acc. No. P01028); lumican (SwissProt Ace. No. P51884); alpha-fibrinogen precursor (SwissProt Ace. No. P02671); IGHG4 protein (Swiss Prot Ace. No. Q8TC63) or immunoglobulin lambda heavy chain. Other marker proteins are also disclosed. | 2008-09-04 |
| 20080213803 | ASSESSMENT OF NEURONS IN THE ARCUATE NUCLEUS TO SCREEN FOR AGENTS THAT MODIFY FEEDING BEHAVIOR - Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used to identify agents of use in treating anorexia or cachexia and can be used to increase appetite and to increase the weight and lean body mass of a subject. | 2008-09-04 |
| 20080213804 | Parallel Processing Fluidic Method and Apparatus for Automated Rapid Immunohistochemistry - A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure. | 2008-09-04 |
| 20080213805 | Method for Distinguishing Follicular Thyroid Adenoma (FTA) from Follicular Thyroid Carcinoma (FTC) - Follicular thyroid adenoma (FTA) is distinguished from follicular thyroid carcinoma (FTC) by comparing amount of an expression product of at least one gene selected from the group consisting of DDIT3, ARG2, ITM1, Clorf24, TARSH, and ACO1 in a test follicular thyroid specimen to a normal control thyroid specimen. The test follicular thyroid specimen is identified as FTA if the amount of expression product of TARSH is equal to or greater in the test follicular thyroid specimen than in the normal control thyroid specimen. The test follicular thyroid specimen is identified as FTC if the amount of expression product of DDIT3, ARG2, ITM1, Clorf24, or ACO1 is greater in the test follicular thyroid specimen than in the normal control thyroid specimen. | 2008-09-04 |
| 20080213806 | Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same - The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is enriched by having been raised in an environment that maintains antigenically active antigen. These antibodies may be used in an immunoreactive environment for detecting the presence of a mycobacterial infection in a sample from a subject. | 2008-09-04 |
| 20080213807 | Methods of Using Bone Morphogenic Proteins as Biomarkers for Determining Cartilage Degeneration and Aging - Methods are provided for determining cartilage degeneration, regeneration, or aging in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and/or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or monitoring joint tissue degeneration, regeneration, or aging in a patient including inflammatory joint disease or age-related disorders. | 2008-09-04 |
| 20080213808 | MEDIATORS FOR PHOTOMETRIC TESTS AND MEANS AND METHODS RELATING TO USE THEREOF - Embodiments of a detection reagent, as well as test elements and analytical kits including such reagent, and methods for using such reagent, are disclosed herein for optical detection and/or measurement of an analyte in a fluid sample. | 2008-09-04 |
| 20080213809 | STABLE NAD/NADH DERIVATIVES - The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits. | 2008-09-04 |
| 20080213810 | Screening Method for Hiv Rt Inhibitors - The present invention is directed to methods for identifying a specific class of inhibitors of HIV reverse transcriptase that act differently from known reverse transcriptase inhibitors. In particular, the invention is based on identifying inhibitors which have higher inhibitory activity in presence of a nucleoside triphosphate or pyrophosphate. | 2008-09-04 |
| 20080213811 | SENSOR PROTEINS AND ASSAY METHODS - The present invention relates to biosensors. In some embodiments, the biosensors are modified ligand binding molecules. In some embodiments, the modified ligand binding molecule is a phosphate binding protein (PBP). In some embodiments, the modified ligand binding molecules are labeled to be capable of RET, e.g., comprising a donor and acceptor moiety. In some embodiments of the invention, there is a detectable change in RET (e.g., FRET) when the modified ligand binding molecule binds and/or releases the ligand (e.g., phosphate). The invention also provides related methods, reactions and assays. | 2008-09-04 |
| 20080213812 | Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression - Methods and compositions are provided for modulating, e.g., increasing or decreasing, the expression of telomerase reverse transcriptase (TERT). In the subject methods, the binding interaction of the TERT Site C repressor site with a Site C repressor protein complex made up of one or more proteins is modulated to achieve the desired change in TERT expression. A feature of the subject invention is that the target Site C repressor protein complex includes an LSF protein. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like. | 2008-09-04 |
| 20080213813 | Histone deacetylase inhibitor and use thereof - To provide a novel apoptosis inducer, and a method of screening an apoptosis inducer. For example, an apoptosis inducer comprising inhibiting HDAC6 such as an antisense oligonucleotide to the gene of histone deacetylase 6 (HDAC6), and anti-cancer agent comprising this apoptosis inducer, and the present invention also provides a method of screening an apoptosis inducer that inhibits HDAC6, and more specifically a method of screening an apoptosis inducer said method comprising the steps of (1) determining whether or not a test substance inhibits histone deacetylase 6 (HDAC6) by using deacetylation of an acetylated substance that can be a substrate for histone deacetylase 6 (HDAC6) or decrease in the expression of histone deacetylase 6 (HDAC6) as an index; and (2) confirming, when inhibition is present, whether it induces apoptosis of the cell in vitro and/or in vivo. | 2008-09-04 |
| 20080213814 | ENZYMATIC ASSAY FOR LSPR - The present invention provides a method of detecting changes in the refractive index at the surface of a localized surface plasmon resonance (LSPR) detection system. The method includes generating an insoluble product from an enzymatic substrate using an immobilized enzyme, wherein the insoluble product accumulates at a LSPR supporting surface. The method also includes detecting changes in the reflected or transmitted light of the surface arising from the presence of the insoluble product using LSPR. | 2008-09-04 |
| 20080213815 | DIAGNOSING BREAST CANCER BY SEPRASE LEVEL - A method of diagnosing subjects for breast cancer comprising the steps of (a) establishing the seprase level of a subjects test material and (b) determining those subjects with seprase levels above about 0.0008 nmoles.min | 2008-09-04 |
| 20080213816 | Mitochondrial enoyl coenzyme a hydratase 1 as marker for diagnosing stomach cancer - The present invention relates to mitochondrial protein that can be used as a marker for diagnosing stomach cancer. According to the present invention, the marker for diagnosing stomach cancer comprises mitochondrial enoyl coenzyme A hydratase 1. | 2008-09-04 |
| 20080213817 | Enhancement of Th2-Dependent and Inflammatory Response - The present invention relates to altering the levels of Th2 cytokine production, and in particular, biasing the cytokine expression profile towards Th2 cytokine production through mitogen-activated protein kinase/ERK kinase kinase 1 (MEKK1), the screening of agents that increase Th2 cytokine production, and the treatment of Th1 associated autoimmune diseases in vivo. In one embodiment, the present invention relates to agents including but not limited to reducing the activity of MEKK1, leading to increased levels of Th2 cytokine production. | 2008-09-04 |
