| 36th week of 2008 patent applcation highlights part 36 |
| Patent application number | Title | Published |
|---|
| 20080213116 | Multi-Stage Rotary Compressor - A multi-stage rotary compressor comprises: a casing having a sealed space therein; a driving unit installed in the casing, for generating a driving force; a first compression unit and a second compression unit for receiving the driving force from the driving unit and compressing a refrigerant; and a connection unit for connecting the first and second compression units and guiding the refrigerant discharged from the second compression unit to be sucked directly in the first compression unit and then re-compressed, by which it is possible to vary capacity, even using every plurality of compression units, and to obtain power saving effect suitable for a saving mode. | 2008-09-04 |
| 20080213117 | Pump Rotor - In pump rotors and used in an internal gear pump, which includes an inner pump rotor having outer gear teeth; an outer pump rotor having inner gear teeth that mesh with the outer gear teeth; and a casing having a pumping-in port through which a fluid is pumped in, and a pumping-out port through which the fluid is pumped out, and pumps in and pumps out the fluid by changing the cell volume formed between gear tooth surfaces of the rotors and so as to carry the fluid when the rotors and mesh with each other and rotate, the rotors are formed from a sintered material of Fe—Cu—C and have a density of not less than 6.6 g/cm | 2008-09-04 |
| 20080213118 | Manufacturing method of a magnesium group composite material - Magnesium composite powder which is a starting raw material to manufacture a particle-dispersion type of magnesium group composite material comprises magnesium alloy coarse particles ( | 2008-09-04 |
| 20080213119 | Process for the Manufacture of Tooth Parts from Dental Grade Metal Powder - When producing tooth replacements from metal, the conventional method of casting is almost exclusively employed, even though said method is a relatively complicated one. The object of the invention is therefore to make available a method that is considerably simpler. In this method, an aqueous suspension, still containing microcrystalline wax and ethoxylated alcohols, is generated with the dental-grade metal powder. The metal powder is deposited on a model by electrophoresis, resulting, for example, in the formation of a cap ( | 2008-09-04 |
| 20080213120 | Martensitic Stainless Steel - Martensitic stainless steel according to the invention contains, by mass, 0.001% to 0.01% C, at most 0.5% Si, 0.1% to 3.0% Mn, at most 0.04% P, at most 0.01% S, 10% to 15% Cr, 4% to 8% Ni, 2.8% to 5.0% Mo, 0.001% to 0.10% Al, at most 0.07% N, 0% to 0.25% Ti, 0% to 0.25% V, 0% to 0.25% Nb, 0% to 0.25% Zr, 0% to 1.0% Cu, 0% to 0.005% Ca, 0% to 0.005% Mg, 0% to 0.005% La, and 0% to 0.005% Ce, with the balance being Fe and impurities, and the steel satisfies Expressions (1) and (2) and has a yield stress in the range from 758 MPa to 860 MPa. In this way, in the martensitic stainless steel according to the invention, the tempering temperature range at which a yield stress in the range from 758 MPa to 860 MPa can be obtained is increased. | 2008-09-04 |
| 20080213121 | Steel For Submarine Hulls With Improved Weldability - The invention relates to a steel for the production of submarine hulls, which is characterised in that the chemical composition thereof comprises, by weight percent: 0.03%≦C<0.08%; 0.04%≦Si≦0.48%; 0.1%≦Mn≦1.4%; 2%≦Ni≦4%; Cr≦0.3%; 0.3%≦Mo+W/2+3(V+Nb/2+Ta/4)≦0.89%; Mo≧0.15%; V+Nb/2+Ta/4≦0.004%; Nb≦0.004%; Cu≦0.45%; Al≦0.1%; Ti≦0.04%; N≦0.03%; the remainder comprising iron and impurities resulting from production, boron being an impurity with a concentration of less than 0.0005% and P+S≦0.015%, the chemical composition satisfying condition 410≦540×C | 2008-09-04 |
| 20080213122 | MOLYBDENUM METAL POWDER AND PRODUCTION THEREOF - Molybdenum metal powder has surface-area-to-mass-ratios in a range of between about 1.0 meters | 2008-09-04 |
| 20080213123 | Doped Iridium with Improved High-Temperature Properties - The invention relates to an iridium alloy of at least 85% by weight iridium, at least 0.005% by weight molybdenum, 0.001 to 0.6% by weight hafnium and, if necessary, rhenium, the sum of molybdenum and hafnium being between 0.002 and 1.2% by weight, and to a process for the production of an iridium alloy, an IrMo and an IrHf master alloy, respectively, being produced in the electric arc and immersed into an iridium melt, if necessary together with Re. | 2008-09-04 |
| 20080213124 | Device and Method For Waste Breakdown and Disinfection or Treatment - The invention concerns a device mounted on a framework comprising an upper compartment ( | 2008-09-04 |
| 20080213125 | Apparatus and Method for Using Ozone as a Disinfectant - A method of sterilizing a closed environment is provided in which an ozone generator is placed into the closed environment; it then generates ozone to a predetermined ozone concentration and increases the humidity of the closed environment. The ozone concentration is maintained at the predetermined ozone concentration for a predetermined period of time, and after the period of time has expired, the ozone is depleted. When the ozone concentration is reduced to a predetermined safe level, the ozone generator signals. | 2008-09-04 |
| 20080213126 | Method and apparatus of ozone injection into sewage forced main - An apparatus and method are provided for introducing high-concentration, high-pressure oxygen gas with or without high-pressure ozone gas into pumped sewage mains, also known as force sewage mains, a portion of the pumped sewage is diverted from the force sewage main for addition of the high-concentration, high-pressure oxygen gas with or without high-pressure ozone gas thereto and for mixing of the gases with the sewage following by reintroduction of the gas-containing sewage into the force sewage main to accomplish the elimination of hydrogen sulfide gas odor from sewage and sewer lines. | 2008-09-04 |
| 20080213127 | Apparatus and Methods For Treating Allograft Products - Apparatus for treating allografts, having a sonication tank configured to transmit ultrasonic energy to the interior of the tank; a treatment canister rotatably positioned in said sonication tank, and configured to receive allografts therein; and a treatment fluid source in fluid communication with said treatment canister. Methods of treating allografts and methods for determining microbial contamination using the apparatus. | 2008-09-04 |
| 20080213128 | Use of Ultraviolet Germicidal Irradiation in Health Care Environments - A method of sterilizing a hospital room to at least 99.99% sterility is described which employs UV/ozone sterilization. A method of sterilizing sink-traps using UV radiation is described. A method utilizing UV/ozone sterilization and sink-trap sterilization by UV radiation for sterilization of an environment is also described. | 2008-09-04 |
| 20080213129 | NON-LINEAR UV LIGHT SOURCES FOR DISINFECTION - The present disclosure provides for systems and methods for disinfecting of components of an HVAC system. At least one non-linear UV light source is positioned within the HVAC system. A non-linear UV light source can include but is not limited to a spherical bulb lamp or a circular lamp. Non-linear UV light sources are positioned about desired HVAC components to deliver UV light to the surface of those components thereby preventing unwanted biological growth. A plurality of non-linear light sources can be positioned throughout the HVAC system including about a heating or cooling coil apparatus, an air moving apparatus such as a fan positioned within an air duct and/or within the air duct to disinfect air flow passing through the air duct. | 2008-09-04 |
| 20080213130 | DIAGNOSTIC-NANOSENSOR AND ITS USE IN MEDICINE - This invention relates generally to biosensor technology, and pertains more particularly to novel multifunctional biosensors based on ordered arrays of metallic, semiconductors and magnetic nano-islands for medical, biological, biochemical, chemical and environmental applications. | 2008-09-04 |
| 20080213131 | PARTICLE AGGLUTINATION-EVALUATING CONTAINER - A particle agglutination-evaluating container for immunological analysis, based on an agglutinate formed in an agglutination reaction between an antibody- or antigen-containing sample and agglutination particles, includes a transparent container body having a bottom face including a sloping bottom face and a raised bottom face extended in a horizontal direction at the top of the sloping bottom face to form an obtuse angle with the sloping bottom face, and a fluidal separation layer containing insoluble particles which are filled in the container body and where the agglutination particles are separated according to the agglutination degree, wherein agglutination is evaluated by observation from the bottom of the container body, where the agglutination reaction is judged positive when the agglutination particles are observed through the raised bottom face, negative when observed at the bottom end of the sloping bottom face, and weakly positive when observed in the middle of the sloping bottom face. | 2008-09-04 |
| 20080213132 | AUTOMATIC ANALYZER - In an automatic analyzer, effect is reduced or prevented of a change in temperature and volume of components making up a mechanism for dispensing a reagent and a sample or a system liquid on an amount of sample and reagent per one dispensing cycle. One or a plurality of components making up the mechanism for dispensing the reagent and the sample is mounted with a sensor for measuring a temperature of the component. The dispensing mechanism further includes a sensor for measuring a temperature of the system liquid at one or a plurality of locations. Control is thereby provided, based on temperature information provided by the temperature sensor, to vary an amount of operation of a component that varies an amount of reagent and sample to be dispensed or to make the temperature of the system liquid equal to, or close to, the temperature of the component. | 2008-09-04 |
| 20080213133 | FLOW ANALYSIS APPARATUS AND METHOD - A flow analysis apparatus is disclosed. The flow analysis apparatus has at least one wicking channel fluidically coupled to an absorbent pump. A wicking valve is fluidically coupled to the wicking channel to provide a fluidic connection to the sample source where opening the wicking valve allows the absorbent pump to cause liquid to flow down the wicking channel toward the absorbent pump. Other similar wicking valves can be added to provide functions such as calibration and reagent addition. A detection unit allows for analysis of the liquid as it flows down the wicking channel. | 2008-09-04 |
| 20080213134 | Device for Supplying Fluids, Method for Producing this Device, and Pipette Comprising Such a Device - The invention proposes a device for active and/or passive supply of fluids comprising a microfluidic component with an inlet and optionally an outlet, a strip conductor which is electrically conductingly connected to the microfluidic component, and a carrier on which the microfluidic component is fixed. In order to provide a simple and inexpensive fluidic connection of the microfluidic component, in accordance with the invention, the carrier is formed by a board comprising the strip conductor, which has one passage channel which is flush with the inlet and optionally one which is flush with the outlet of the microfluidic component, and wherein a feed line for the inlet or an outlet line for the outlet is formed by a channel opening into the passage channel, wherein the channel is formed on the side of the board facing away from the microfluidic component by one groove-like recess each. The microfluidic component can e.g. be formed by a micropump, a microvalve or a microsensor, in particular, for measuring the pressure. The invention also concerns a method for producing such a device and a pipetting and pressure measuring device which comprises a device of the above-mentioned type. | 2008-09-04 |
| 20080213135 | Wireless enabled device - The invention described herein provides an embedded wireless device such as a RFID tag molded into separate housing formed of any thermoplastic material compatible to that of the plastic material as the device to which the housing is to be attached. Subsequently, the housed tag assembly can be thermally bonded onto the device through many means which are well known and accepted in the industry. | 2008-09-04 |
| 20080213136 | CLOSED CIRCUIT AEROSOL AND VAPOR CHAMBER WITH COUNTER FLOW CONFIGURATION - An aerosol and vapor generation device comprises a container, a generation input for a contaminated product to be diluted in the device, a generation output, and a clean gas input. The device also includes a dilution tube in the container, with the generation input and with the clean gas input being in fluid communication with the dilution tube. The container defines a chamber, and a number of sampling ports are provided in the container such as to fluidly connect the chamber with outside units. The contaminated product and the clean gas are conveyed to the container such as to be mixed in the dilution tube and to displace therein in a first direction. The mixture then exits the dilution tube into the chamber and hits a wall of the container so as to be redirected in the chamber in a substantially counterflow direction with respect to the first direction. A sample of the mixture in the chamber can be drawn therefrom via the sampling ports. | 2008-09-04 |
| 20080213137 | SYSTEM AND METHOD FOR SEPARATING BIOMASS FROM MEDIA IN A FLUIDIZED BED REACTOR - A system is provided for separating biomass from media in a fluidized bed reactor containing an aqueous suspension of biomass and media. A lift, configured to extend within the reactor, has an inlet for receiving aqueous suspension and an outlet spaced from the inlet for delivering the aqueous suspension from the lift. A shield is disposed about the lift. The system further includes a biomass separator body, including an inner member disposed about the shield and an outer member. Three annular passageways are defined between the lift, the shield, the inner member, and the outer member, and are positioned to receive aqueous suspension from each other. A barrier extends between the inner member and the outer member at an end portion of the third annular passageway. The barrier of the biomass separator body is configured to direct biomass from the third annular passageway toward an excess biomass discharge. | 2008-09-04 |
| 20080213138 | Production Method and Production Device for Carbon Nano Structure - A material gas and a catalyst are introduced through a material supplying tube path and a catalyst supplying tube path together with a carrier gas into a reactor equipped on its outer periphery with a heat applicator for thermally decomposing the material gas. The reactor has a convention regulator fitted to the discharge end of the catalyst supplying tube path. The convection regulator covers an edge side of the reactor to regulate gas flow in the reactor so that the flow does not reach the edge side. Due to this, a convection state can be efficiently produced in a reaction region. Consequently, it becomes possible to prevent contamination defect caused by accumulation/adherence of concretion of catalyst, which was generated by aggregation of cooled catalyst in the low-temperature region of the reactor and a decomposition product of the material gas. Thus the efficiency of carbon nanostructure production can be improved. | 2008-09-04 |
| 20080213139 | Medical Instrument Disinfecting Chamber Via Radiation - The invention concerns a medical instrument disinfecting chamber, of the type comprising means ( | 2008-09-04 |
| 20080213140 | OZONE GENERATOR - An ozone generator for generating ozone by applying a specified process to oxygen by discharge includes a first raw material gas supply unit for supplying the oxygen as a first raw material gas, and a second raw material gas supply unit for supplying an oxide compound gas as a second raw material gas, in which, by excited light, excited and generated by a discharge in the oxygen and the oxide compound gas, the oxide compound gas is dissociated, or the oxide compound gas is excited accelerating dissociation of the oxygen, and ozone is generated. In this way, ozone generation efficiency is raised. | 2008-09-04 |
| 20080213141 | PROCESSING APPARATUS FABRICATION - A processing apparatus that is formed from a plurality of metal layers that are stacked and aligned together and then connected together to form one or more portions of the processing apparatus. | 2008-09-04 |
| 20080213142 | MEMBRANE REACTOR FOR SHIFT REACTION - There is disclosed a membrane reactor | 2008-09-04 |
| 20080213143 | CHEMICAL REACTION CARTRIDGE AND METHOD FOR USING - Disclosed is a chemical reaction cartridge including an elastic body with which at least a portion of the chemical reaction cartridge is formed and a plurality of chambers and a flow path to connect the plurality of chambers, which contain solution inside, and the solution is moved or blocked in the chambers and the flow path by applying external force to the elastic body from outside, the elastic body is structured in at least two elastic body layers which are layered vertically and the plurality of chambers and the flow path are provided between an upper elastic body layer and a lower elastic body layer, and the elastic body is attached to a surface of a substrate made of hard material. | 2008-09-04 |
| 20080213144 | VOC reduction in ethanol plants - Byproduct solids produced in the processing of carbohydrate material to produce ethanol are dried in a recirculating stream of gaseous carbon dioxide into which carbon dioxide produced in that processing is fed. Organic contaminants and water vapor report to the recirculating carbon dioxide stream and are removed therefrom. | 2008-09-04 |
| 20080213145 | Method of Decomposing Nitrogen Dioxide - A method of decomposing NO | 2008-09-04 |
| 20080213146 | TECHNICAL AND ECONOMIC OPTIMIZATION OF COMBUSTION, NITROGEN OXIDES, SULFUR DIOXIDE, MERCURY, CARBON DIOXIDE, COAL ASH AND SLAG AND COAL SLURRY USE IN COAL FIRED FURNACES/BOILERS - Improvements in methods by which new or used coal fired boilers whether designed for coal or oil or natural gas firing can substantially improve their technical operation and reduce their capital and operating costs by implementing process steps that (a) minimize the adverse impacts of coal ash and slag on boiler surfaces and particulate emissions, which will improve coal combustion efficiency and facilitate the use of oil or gas designed boilers for coal firing, (b) drastically reduce the loss of water used to transport coal in slurry form to power plants, (c) minimize the combined total nitrogen oxides (NO | 2008-09-04 |
| 20080213147 | Process for treating a gas stream - Processes for selectively removing sulfur-containing compounds from a gas are described herein. The processes generally include contacting a first gas including carbon dioxide and hydrogen sulfide with a scrub solution including ammonium bisulfite and ammonium sulfite in a first contact zone to produce a first contact zone effluent liquid including ammonium thiosulfate and a first contact zone overhead gas in which the concentration of hydrogen sulfide is substantially reduced. | 2008-09-04 |
| 20080213148 | Emission Control System - Methods and apparatus utilizing chlorine dioxide and hydrogen peroxide are useful to reduce NOx emissions, as well as SOx and mercury (or other heavy metal) emissions, from combustion flue gas streams. | 2008-09-04 |
| 20080213149 | Process for producing steam and/or power from oil residues - Power is produced using fuel from raw and/or preprocessed oil residues which are burned alone, without any addition of sorbents, diluents or the like, to generate high pressure steam and/or power and residual emissions. Residual emissions are cleaned to simultaneously remove PM, NO | 2008-09-04 |
| 20080213150 | Method for Controlling Nox Emissions in the Fccu - Processes for the reduction of NO | 2008-09-04 |
| 20080213151 | Pr-Containing Scintillator Single Crystal, Method of Manufacturing the Same, Radiation Detector, and Inspection Apparatus - The present invention provides an oxide-base scintillator single crystal having an extremely large energy of light emission, adoptable to X-ray CT and radioactive ray transmission inspection apparatus, and more specifically to provide a Pr-containing, garnet-type oxide single crystal, a Pr-containing perovskite-type oxide single crystal, and a Pr-containing silicate oxide single crystal allowing detection therefrom light emission supposedly ascribable to 5d-4f transition of Pr. | 2008-09-04 |
| 20080213152 | Method of Producing UV-Emitting Magnesium Pentaborate Phosphors - A method of producing a UV-emitting magnesium pentaborate phosphor is described. The method comprises combining a hydrated magnesium hexaborate with oxides of Y, Gd, Ce and Pr to form a mixture and firing the mixture in a slightly reducing atmosphere to form the phosphor. The hydrated magnesium hexaborate, which is preferably prepared as a precipitate, preferably has a formula MgB | 2008-09-04 |
| 20080213153 | Method of Making Red-Emitting Borate Phosphor - There is described a method of producing a red-emitting manganese and cerium co-activated gadolinium magnesium zinc pentaborate phosphor that comprises combining a hydrated hexaborate of zinc, magnesium, and manganese with oxides of Gd and Ce to form a mixture, and firing the mixture in a slightly reducing atmosphere to form the phosphor. Preferably, the hydrated hexaborate has an approximate composition represented by (Zn,Mg,Mn)B | 2008-09-04 |
| 20080213154 | Divided Solid Composition Composed of Grains Provided with Continuous Metal Deposition, Method for the Production and Use Thereof in the Form of a Catalyst - This invention relates to a solid divided composition comprising grains whose mean size is greater than 25 μm and less than 2.5 mm, wherein each grain is provided with a solid porous core and a homogeneous continuous metal layer consisting of at least one type of transition non-oxidised metal and extending along a gangue coating the core in such a way that pores are inaccessible. A method for the production of said composition and for the use thereof in the form of a solid catalyst is also disclosed. | 2008-09-04 |
| 20080213155 | Method for siliconizing carbon-containing Materials - A method for treating workpieces that consist of porous carbon material with liquid silicon with the formation of silicon carbide, comprising the steps: Preheating porous carbon workpieces under inert gas to the selected operating temperature T | 2008-09-04 |
| 20080213156 | Method For The Manufacture Of A Reactor To Separate Gases - Method for manufacturing a reactor for separating a gas containing silicon, comprising the following stages: preparation of a substantially tubular reactor blank with an inner wall and an outer wall, and application of a separating layer containing a powdery separating medium, at least onto the inner wall of the reactor blank. The reactor with the separating layer applied thereon offers simple and effective protection of the inner wall from deposited silicon powder. The separating layer and the silicon powder deposited thereon can easily be removed mechanically, without the inner wall being damaged. | 2008-09-04 |
| 20080213157 | PROCEDURES FOR AMMONIA PRODUCTION - Systems and methods for producing ammonia. In one approach, Li | 2008-09-04 |
| 20080213158 | Apparatus for production of crystal of group III element nitride and process for producing crystal of group III element nitride - A manufacturing apparatus of Group III nitride crystals and a method for manufacturing Group III nitride crystals are provided, by which high quality crystals can be manufactured. For instance, crystals are grown using the apparatus of the present invention as follows. A crystal raw material ( | 2008-09-04 |
| 20080213159 | Nanotube separation methods - A nanotube separation method includes depositing a tag on a nanotube in a nanotube mixture. The nanotube has a defect and the tag deposits at the defect where a deposition rate is greater than on another nanotube in the mixture lacking the defect. The method includes removing the tagged nanotube from the mixture by using the tag. As one option, the tag may contain a ferromagnetic material and the removing may include applying a magnetic field. As another option, the tag may contain an ionic material and the removing may include applying an electric field. As a further option, the tag may contain an atom having an atomic mass greater than the atomic mass of carbon and the removing may include applying a centrifugal force to the nanotube mixture. Any two or more of the indicated removal techniques may be combined. | 2008-09-04 |
| 20080213160 | Method of Synthesising a Support Catalyst for the Production of Carbon Nanotubes - The present invention relates to a method for synthesising a catalyst with a view to the production of multi-wall nanotubes comprising the following stages:
| 2008-09-04 |
| 20080213161 | Carbon nanotube pastes and methods of use - Discernable pastes comprising single-walled carbon nanotubes (SWNT) in water or in an organic solvent are prepared. The method of preparing the Discernable pastes comprises in general the following steps: a) removal of the catalyst used during the synthesis of SWNT; b) while the SWNT are still wet, addition of the appropriate amount of solvent, in a solvent/SWNT ratio which preferably varies between 30:1 and 100:1, depending on the desired viscosity of the paste; and c) high-energy horn sonication with a dismembrator probe. | 2008-09-04 |
| 20080213162 | Amplification of Carbon Nanotubes Via Seeded-Growth Methods - The present invention is directed towards methods (processes) of providing large quantities of carbon nanotubes (CNTs) of defined diameter and chirality (i.e., precise populations). In such processes, CNT seeds of a pre-selected diameter and chirality are grown to many (e.g., hundreds) times their original length. This is optionally followed by cycling some of the newly grown material back as seed material for regrowth. Thus, the present invention provides for the large-scale production of precise populations of CNTs, the precise composition of such populations capable of being optimized for a particular application (e.g., hydrogen storage). The present invention is also directed to complexes of CNTs and transition metal catalyst precurors, such complexes typically being formed en route to forming CNT seeds. | 2008-09-04 |
| 20080213163 | Method for Producing BaLiF3 Single Crystal - Disclosed is a method for producing a BaLiF | 2008-09-04 |
| 20080213164 | Method for producing hydrogen peroxide - The present invention provides a method for producing hydrogen peroxide, comprising the steps of: alternately reducing and oxidizing a working solution containing anthraquinone compounds as a reaction medium, wherein a mixture of alkyl-substituted anthraquinones and alkyl-substituted tetrahydroanthraquinones in a molar ratio of from 2:1 to 8:1 is used as the anthraquinone compounds in the working solution, in the reduction step all of the tetrahydroanthraquinones and some or all of the anthraquinones in the working solution are reduced; and keeping the content of alkyl-substituted anthrahydroquinones in the working solution after the reduction step and before the oxidation step higher than the content of alkyl-substituted tetrahydroanthrahydroquinones, wherein ethylanthraquinone and ethyltetrahydroanthraquinone are used as anthraquinone compounds in the working solution in a total proportion of both of from 10 to 45 mol % of all of the anthraquinone compounds in the working solution. | 2008-09-04 |
| 20080213165 | Methods and Compositions for Increasing Patent Tolerability During Myocardial Imaging Methods - The present application discloses methods and compositions for increasing patient tolerability during myocardial imaging comprising the administration of doses of caffeine and one or more adenosine A | 2008-09-04 |
| 20080213166 | Novel Gene Targets and Ligands that Bind Thereto for Treatment and Diagnosis of Colon Carcinomas - Isolated nucleic acids and proteins that are overexpressed in human cancers, and antibodies that specifically bind the proteins, which are useful diagnostic and therapeutic targets. | 2008-09-04 |
| 20080213167 | USE OF CD23 ANTAGONISTS FOR THE TREATMENT OF NEOPLASTIC DISORDERS - Methods and kits for the treatment of neoplastic disorders comprising the use of a CD23 antagonist are provided. The CD23 antagonist may be used alone or in combination with chemotherapeutic agents. In particularly preferred embodiments the CD23 antagonists may be used to treat B cell chronic lymphocytic leukemia (B-CLL). | 2008-09-04 |
| 20080213168 | USE OF CD23 ANTAGONISTS FOR THE TREATMENT OF NEOPLASTIC DISORDERS - Methods and kits for the treatment of neoplastic disorders comprising the use of a CD23 antagonist are provided. The CD23 antagonist may be used alone or in combination with chemotherapeutic agents. In particularly preferred embodiments the CD23 antagonists may be used to treat B cell chronic lymphocytic leukemia (B-CLL). | 2008-09-04 |
| 20080213169 | Cytotoxicity mediation of cells evidencing surface expression of CD59 - This invention relates to the staging, diagnosis and treatment of cancerous diseases (both primary tumors and tumor metastases), particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more CDMAB/chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays, which utilize the CDMAB of the instant invention. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells. | 2008-09-04 |
| 20080213170 | Cancerous Disease Modifying Antibodies - The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells. | 2008-09-04 |
| 20080213171 | Cancerous disease modifying antibodies - The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells. | 2008-09-04 |
| 20080213172 | RADIOIMAGING MOIETIES COUPLED TO PEPTIDEASE-BINDING MOIETIES FOR IMAGING TISSUES AND ORGANS THAT EXPRESS PEPTIDASES - Conjugates, methods and kits are described for imaging tissues and organs that express one or more peptidases. In a preferred embodiment of the invention, a series of di-(2-pyridylmethyl)amine (D) ligands, which can bind M(CO) | 2008-09-04 |
| 20080213173 | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid - The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6 and other sequence positions of a fatty acid backbone. These novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest. | 2008-09-04 |
| 20080213174 | Radiolabelled Insulin - The invention relates to in vivo imaging agents, specifically radiolabelled insulin derivatives of formula (III); wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—, and is preferably —CO—NH—, —NH— or —O—; Y is H, alkyl or aryl substituents; R* is a radiolabel moiety suitable for detection by SPECT or PET; and methods for preparing the same as well as their use in in vivo imaging methods. | 2008-09-04 |
| 20080213175 | Click chemistry-derived cyclic peptidomimetics as integrin markers - The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT). | 2008-09-04 |
| 20080213176 | Compositions for Targeting Amine Oxidases in Vivo - This invention relates to a diagnostic compositions for targeting an amine oxidase enzyme in vivo, said composition comprising a labelled peptide having the capability to bind to said enzyme. Further, the invention concerns a pharmaceutical composition for use to modulate the activity of an amine oxidase enzyme, said composition comprising a peptide having the capability to bind to said enzyme, wherein said peptide further is conjugated to a therapeutically active agent. Still further, the invention concerns a novel peptide and its uses, especially as VAP-1 inhibitor. | 2008-09-04 |
| 20080213177 | Nanoparticles Comprising Rna Ligands - Materials and methods are provided for making nanoparticles having a core including metal and/or semiconductor atoms, which core is covalently linked to a plurality of ligands comprising a RNA ligand. The RNA ligands may include siRNA or miRNA. Also provided are uses of these nanoparticles in therapy and diagnosis. | 2008-09-04 |
| 20080213178 | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid - The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6 and other sequence positions of a fatty acid backbone. These novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest. | 2008-09-04 |
| 20080213179 | Differentially Expressed Nucleic Acids in the Blood-Brain Barrier Under Inflammatory Conditions - The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain barrier functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain barrier properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers. | 2008-09-04 |
| 20080213180 | CA IX-Specific Inhibitors - Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds, preferably organic compounds, preferably aromatic and heterocylic sulfonamides, which inhibit the enzymatic activity of MN/CA IX and that are useful for treating patients with preneoplastic/neoplastic disease. Further, the CA IX-specific inhibitors when labeled or linked to an appropriate visualizing means can also be used diagnostically/prognostically for preneoplastic/neoplastic disease, and for imaging use, for example, to detect hypoxic precancerous cells, tumors and/or metastases, by selectively binding to activated CA IX, preferably CA IX activated under hypoxic conditions, and not to inactive CA IX. Such detection of hypoxic conditions can be helpful in determining effective treatment options, and in predicting treatment outcome and the prognosis of disease development. Still further, the CA IX-specific inhibitors can be used therapeutically to selectively target hypoxic cells expressing activated CA IX. The CA IX-specific inhibitors can be labelled or conjugated to radioisotopes for radiotherapy of hypoxic cells. Alternatively, the CA IX-specific inhibitors can be used for gene therapy coupled to vectors for targeted delivery to hypoxic preneoplastic/neoplastic cells expressing activated CA IX on their surfaces. | 2008-09-04 |
| 20080213181 | Preparation of Paramagnetic Nanoparticles Conjugated to Leukotriene B4 (LTB4) Receptor Antagonists, and Their Use as MRI Contrast Agents for the Detection of Infection and Inflammation - Nanoparticle-based compositions and emulsions that are specifically targeted to leukotriene B4 (LTB4) receptors, and employing LTB4 receptor antagonist targeting agents, are set forth. In addition, there is provided the use of non-antibody based compositions for such targeting. The compositions of the invention are useful as imaging agents in diagnostic and therapeutic applications. | 2008-09-04 |
| 20080213182 | Methods and Compositions for Treatment of Diseases Associated with Aberrant Microsatellite Expansion - The present invention provides methods and compositions for the treatment of diseases associated with aberrant microsatellite expansions. Methods of the present invention comprise the use of recombinant adeno-associated virus vectors containing a transgene encoding at least one muscleblind protein. The present invention also provides an animal model for a disease associated with aberrant microsatellite expansion. | 2008-09-04 |
| 20080213183 | Free or Liposomal Gemcitabine Alone or in Combination with Free or Liposomal Idarubicin - The use of the maximum tolerated dose (MTD) of individual drugs to determine appropriate administration ratios of drugs for combination therapy, wherein the ratios of drugs are fixed based on the same percentage of the MTD for each drug. Furthermore, antineoplastic compositions comprising liposomal encapsulated gemcitabine alone or in combination with free or liposomal encapsulated antineoplastic agents, such as idarubicin, irinotecan, etopside, cisplatin, cyclophosphamide, doxorubicin, or vincristine are diclosed. | 2008-09-04 |
| 20080213184 | METHODS FOR MODULATING A DRUG-RELATED EFFECT OR BEHAVIOR - The present invention provides a method of reducing or preventing a drug-related effect or behavior in a subject by inhibiting N-type calcium channels. In addition, the invention provides a variety of prescreening and screening methods aimed at identifying agents that modulate a drug-related effect or behavior. These methods involve assaying test agent binding to N-type calcium channels or channel subunits. Alternatively, test agents can be screened for their ability to alter the level of N-type calcium channels, channel subunit polypeptide or RNA, or the depolarization-induced inward calcium current mediated by these channels. Finally, the invention also provides a diagnostic method that entails measuring one or more of these levels and determining risk for a drug-related effect or behavior based on comparison to the corresponding level for a control population. | 2008-09-04 |
| 20080213185 | Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof - The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer. | 2008-09-04 |
| 20080213186 | Method of Producing a Composition, Composition and Its Use - The invention relates to a method of producing a composition comprising hyperpolarised | 2008-09-04 |
| 20080213187 | NOVEL CASCADE POLYMER COMPLEXES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM - The invention relates to novel cascade polymer complexes, to compositions comprising these compounds, to the use of the complexes in NMR diagnosis, and to processes for preparing these compounds and compositions. The complex-forming cascade polymer complexes according to the invention can be described by general formula I: | 2008-09-04 |
| 20080213188 | NOVEL OPHTHALMIC COMPOSITIONS CONTAINING HUMAN RECOMBINANT LYSOZYME AND USE THEREOF FOR TREATING EYE CONDITIONS AND AS CONTACT LENS SOLUTIONS - An ophthalmic solution comprising: a) a human recombinant lysozyme; b) one or more natural lacrophyl substances; c) water; and d) optionally one or more therapeutic substances. The ophthalmic solution is useful to treat dry eye conditions and eye inflammation and also to condition and/or cleanse contact lenses. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims. | 2008-09-04 |
| 20080213189 | Multifunctional metal-graphite nanocrystals - Disclosed are nanocrystals comprising metals and metal alloys, which are formed by a process that results in a layer of graphite in direct contact with the metallic core. The nanocrystals may be used in vivo as MRI contrast agents, X-ray contrast agents, near IR (NIR) heating agents, drug delivery, protein separation, catalysis etc. The nanocrystals may be further functionalized with a hydrophilic coating, e.g., phospholipid-polyethylene glycol, which improves in vivo stability. The process comprises chemical vapor deposition of metals adsorbed onto silica as a fine powder, in conjunction with a carbon containing gas, which coats the metal particles. The silica is then etched away. Preferred metals include iron, gold, cobalt, platinum, ruthenium and mixtures thereof, e.g., FeCo and AuFe. The process permits control of the alloy compositions, size, and other characteristics. | 2008-09-04 |
| 20080213190 | Selective Alfavbetas Receptor Peptide Antagonist for Therapeutic and Diagnostic Applications - The present invention is related to new peptide antagonists of α | 2008-09-04 |
| 20080213191 | Composition and/or articles comprising cyclodextrin complexing material - Personal care products are provided. An exemplary personal care product includes a composition that is applied to the body or clothing, or an article applied against the body; a plurality of particles associated with the composition or a component of the article, the plurality of particles, at least some of the plurality of particles comprising a cyclodextrin complexing material and a first fragrance material, wherein the percent of the first fragrance material that is complexed with the cyclodextrin is greater than about 90%, so that the perceptibility of the first fragrance is minimized prior to its release; and a second fragrance material that is not complexed with the cyclodextrin and that is different from the first fragrance material, wherein the composition or article does not contain an antiperspirant active. | 2008-09-04 |
| 20080213192 | AEROSOL LOTION FORMULATIONS - Non-foaming aqueous emulsion compositions; methylparaben-based preservative systems for aqueous aerosol compositions having a pH at or above a pH where methylparaben begins to hydrolyze; cosmetic, household, and human and veterinary pharmaceutical products containing these compositions. | 2008-09-04 |
| 20080213193 | Foam skin cream, uses of the foam skin protection cream and a process for its preparation - A foam skin cream can be obtained by
| 2008-09-04 |
| 20080213194 | Rhamnolipid-based formulations - The present invention relates to rhamnolipid-based formulations to clean, disinfect, deodorize, and act as an antimicrobial and antifungal agent for living and working environments. In addition, the present invention relates to the use of rhamnolipids to create a bio-film when applied to a surface, which prevents the growth of bacteria and fungus. This technique is especially useful to create clean surface areas for medical procedures, chemical testing, during food preparation, as well as for daycare centers and hospitals. | 2008-09-04 |
| 20080213195 | Antibacterial Dentifrice Exhibiting Antiplaque and Breath Freshening Properties - A dual component antiplaque oral composition having antimalodor properties in which a first component contains an antibacterial agent and the second component contains a proteolytic enzyme, the first and second components are simultaneously combined for application to the teeth, the first and second components being physically segregated prior to use, the components when mixed upon application to teeth providing substantially antiplaque effect with superior antimalodor properties. | 2008-09-04 |
| 20080213196 | ENZYME CONTAINING COMPOSITION, PROCESS OF PRODUCING SAID COMPOSITION AND ITS USE - The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000:1 to 1:1,000,000 and wherein the composition has a total enzyme activity of at least 2 U/ml. Furthermore, the present invention relates to a process of producing such enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries. | 2008-09-04 |
| 20080213197 | AGENT FOR PROTECTION OF TOOTH SURFACES, IN CONJUNCTION WITH CONVENTIONAL BLEACHING METHODS, BY BIOMIMETIC DEPOSITION OF FLUORAPATITE - An agent for protection of tooth surfaces, in conjunction with conventional bleaching methods, by biomimetic deposition of fluorapatite, containing
| 2008-09-04 |
| 20080213198 | Cosmetic or Dermopharmaceutical Composition Comprising at Least one Udp Glucuronosyl Transferase (Ugt) Enzymes Inducer - The invention relates to topical use of at least one UGT inducer for the preparation of a cosmetic or dermopharmaceutical composition comprising a dermatologically acceptable carrier to protect and/or enhance the state of the skin and prevent and/or treat imperfections of the skin. | 2008-09-04 |
| 20080213199 | Amphoteric Polysaccharide Compounds Containing Aldehyde Function(S), Composition Comprising Them and Cosmetic Use Thereof - The present invention relates to novel amphoteric polysaccharide compounds containing aldehyde function(s) corresponding to the formula (I): P—(O—(Y) | 2008-09-04 |
| 20080213200 | MICRONIZED ZINC OXIDE SKIN PROTECTOR FORMULATION - The invention provides a topical sunscreen comprising micronized zinc oxide, titanium oxide and iron oxide, and a hydrotrope and water. The sunscreen according to the invention protects against the harmful effects of UV, IR and visible irradiation. | 2008-09-04 |
| 20080213201 | SELF-TANNING COMPOSITION, USE OF DHA IN COMBINATION WITH MINERAL OIL, AND A SKIN SELF-TANNING METHOD - The present invention relates to a cosmetic and/or dermatological self-tanning composition containing reduced DHA content and that uses the unexpected synergistic tanning effect of the joint use of DHA and mineral oil in obtaining an even tan, without stains and without producing skin dryness. The composition exhibits an improved stability by virtue of the lower DHA concentration and, through combination of specific components present in its composition, provides skin hydration together with self-tanning. | 2008-09-04 |
| 20080213202 | Composition For Improving Skin Lipid Barrier Function - The invention relates to a composition for topical application to the skin comprising effective amounts of a protease inhibitor and a cell differentiation enhancer. The composition is useful in promoting skin lipid barrier repair and maintaining the integrity of the lipid barrier. In this regard, the compositions can be used in the treatment and prevention of dry skin, and associated chrono/proto-aging conditions, in the treatment and prevention of irritation on the skin, in the treatment and prevention of UV-related damage to the skin, and in the enhancement of the retention of self-tanning. | 2008-09-04 |
| 20080213203 | Antiperspirant compositions comprising cyclodextrin complexing material - Antiperspirant compositions are provided. An exemplary composition includes a carrier material; an antiperspirant active in an amount from about 5% to less than 19%, by weight of the composition and on an anhydrous basis; and plurality of particles comprising a cyclodextrin complexing material and a fragrance material, wherein the percent of the fragrance material that is complexed with the cyclodextrin is greater than about 75%, so that the perceptibility of the fragrance is minimized prior to its release, wherein the composition has a Residue Grade of less than about 35. | 2008-09-04 |
| 20080213204 | Antiperspirant compositions comprising cyclodextrin complexing material - Antiperspirant compositions are provided. An exemplary composition includes an anhydrous carrier; an antiperspirant active; a plurality of particles comprising a cyclodextrin complexing material and a first fragrance material, wherein the percent of the first fragrance material that is complexed with the cyclodextrin is greater than about 75%, so that the perceptibility of the first fragrance is minimized prior to its release; and a second fragrance material that is not complexed with the cyclodextrin and that is different from the first fragrance material, wherein the composition exhibits an Antiperspirant Efficacy Index of less than 1.19. | 2008-09-04 |
| 20080213205 | Depilatory Composition in Emulsion form, Process for Preparation and Use - Depilatory compositions comprising a depilatory agent, fatty alcohol and an oil-gelling agent provide improved resistance to rinsing of the compositions from the skin. The compositions provide for a method of depilation in wet conditions using a tool to apply and remove the compositions. | 2008-09-04 |
| 20080213206 | Cosmetic Composition Comprising at Least One Fatty-Chain Polylysine, Which is Intended to Improve the Surface State of Keratin Fibers - The present invention relates to a cosmetic composition comprising, in a cosmetically acceptable medium, at least one fatty-chain polylysine. The composition of the invention enables to improve the surface state of keratin fibres. The invention also relates to methods for producing fatty-chain polylysines, as well as new compounds. | 2008-09-04 |
| 20080213207 | Shaving Preparation and Method for Shaving - Disclosed is a shaving preparation imparting durable lubricity. The shaving preparation has one or more silicone polyethers and one or more water-soluble polymers that associate with the one or more silicone polyethers in aqueous solution. The lubricity of the shaving preparation can be reactivated by wetting the skin after shaving without applying an additional amount of the shaving preparation. Also disclosed is a method for using the shaving preparation. | 2008-09-04 |
| 20080213208 | Polyamino and/or Polyammonium/Polysiloxane Copolymer Compounds With Polyalkylene Oxide Units In Comb-Shaped Arrangement - The invention concerns polyamino and/or polyammonium/polysiloxane copolymer compounds with polyalkylene oxide units in comb-shaped arrangement, a method for producing said compounds and their use, in particular for treating textiles and other natural or synthetic textile materials. | 2008-09-04 |
| 20080213209 | Process for Producing Cross-Linked Material of Polylactic Acid and Cross-Linked Material of Polylactic Acid - A cross-linked material of polylactic acid produced by preparing a polylactic acid composition by mixing polylactic acid with at least a plasticizer containing either a rosin derivative or a dicarboxylic acid derivative and/or a glycerin derivative and cross-linking monomer, and kneading the resulting mixture; preparing a polylactic acid molded product by molding the composition into a desired shape; and then cross-linking the molded product by irradiation of ionizing radiation. | 2008-09-04 |
| 20080213210 | Method to purify poly(vinyl alcohol) - Disclosed herein is a process to produce a film comprising poly(vinyl alcohol), wherein the poly (vinyl alcohol) solution has been purified utilizing an ion exchange resin. An approximate 50 micrometer thick film produced from the purified aqueous poly(vinyl alcohol) solution has an APHA color value of 50 or less after the film has been heated at 150° C. for 60 minutes. | 2008-09-04 |
| 20080213211 | COMPOSITIONS AND METHODS FOR HEALTHY PREGNANCY - Compositions, kits and methods for the prevention of, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure during assisted reproduction are provided. The compositions, kits and methods provide an effective amount of granulocyte colony stimulating factor to prevent, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure of an embryo. | 2008-09-04 |
| 20080213212 | Sialoadhesin factor-2 antibodies - Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents | 2008-09-04 |
| 20080213213 | Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione - Methods of treating, preventing and/or managing a myelodysplastic syndrome are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient, and/or blood or cells for transplantation therapy. Specific second active ingredients are capable of affecting or improving blood cell production. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed. | 2008-09-04 |
| 20080213214 | Treating Cardiovascular Tissue - This document provides methods and materials for treating cardiovascular tissue. For example, stem cells, compositions containing stem cells, methods for obtaining stem cells, compositions for generating stem cells expressing particular markers, and methods for repairing cardiovascular tissue are provided. | 2008-09-04 |
| 20080213215 | Concentrated Protein Lyophilates, Methods, and Uses - The invention provides, among other things, lyophilized compositions of high surface area that comprise a protein and that reconstitute quickly and efficiently to solution of high protein concentration with minimal formation, if any, of foam, effervescence, bubbles, turbidity, or particulates that might be deleterious. The invention also provides, among other things, methods for making the lyophilized compositions. The invention in additional aspects also provides Raman Imaging Spectrographic methods for real time analyses of polymorphs in a sample using PLS algorithms. By way of particular example, the use of the method for the analysis of mannitol polymorphs is described, and the use of the analysis to determine optimum compositions and lyophilization methods for producing lyophilates of pharmaceutical proteins having a predefined distribution of mannitol polymorphs and having the aforementioned reconstitution properties is also described. | 2008-09-04 |
