36th week of 2015 patent applcation highlights part 14 |
Patent application number | Title | Published |
20150246858 | PROCESS FOR RECOVERING BENZENE AND FUEL GAS IN AN AROMATICS COMPLEX - A process for separating xylene from a feedstock in which the feedstock is separated into a xylene stream, a benzene rich stream and a light ends stream. Two separation zones may be utilized in which liquid from both is sent to a stabilization zone and the vapor from the stabilization zone is combined with a stream prior to the stream entering the second separation zone. | 2015-09-03 |
20150246859 | Configurations and Methods for Nitrogen Rejection, LNG and NGL Production from High Nitrogen Feed Gases - Variable N2 content in feed gas ranging from 3 mole % to 50 mole % can be rejected from the process using a feed exchanger that is fluidly coupled with a cold separator and a single fractionation column to produce a nitrogen vent stream and streams that are suitable to be further processed for NGL recovery and LNG production. | 2015-09-03 |
20150246860 | Xylene Separation Process - A process is described for separating paraxylene from a multicomponent fluid mixture of C8 aromatics, and more particularly to a process for separating paraxylene from such a fluid mixture by means of adsorption apparatus, such as moving-bed or simulated moving-bed adsorption apparatus. A process is also described for making paraxylene by making a mixture of C8 aromatics and separating paraxylene from the mixture by means of a simulated moving-bed adsorption apparatus. | 2015-09-03 |
20150246861 | METHOD FOR PREPARING ALLYL ALCOHOL - Disclosed is a method for preparing allyl alcohol, wherein glycerol and formic acid are reacted under specific synthesis conditions, thus remarkably increasing the the concentration of allyl alcohol in the liquid reaction products and minimizing the production of allyl formate byproduct and the production of unreacted formic acid. | 2015-09-03 |
20150246862 | PREPARATION OF PENTANOL WITH ETHANOL DERIVED FROM FERMENTATION - In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc. | 2015-09-03 |
20150246863 | Synthesis of Guerbet Alcohols - A method and system for preparing a mixture of Guerbet alcohols where one or more primary alcohols of the formula RCH | 2015-09-03 |
20150246864 | PROCESS FOR PREPARING 4-CYCLOHEXYL-2-METHYL-2-BUTANOL - A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising:
| 2015-09-03 |
20150246865 | PROCESS FOR MAKING LEVULINIC ACID - A process is described wherein a feed of a six-carbon carbohydrate-containing material or of a furanic dehydration product from a six-carbon carbohydrate-containing material or of a combination of these is supplied to a reactor in a controlled manner over time, and the feed is acid-hydrolyzed to produce levulinic acid. In certain embodiments, derivatives of the levulinic acid are prepared. | 2015-09-03 |
20150246866 | ACETIC ACID PRODUCTION PROCESS - Processes for producing acetic acid and determining corrosion therein are described herein. The processes generally include contacting methanol and carbon monoxide in the presence of a liquid reaction medium under carbonylation conditions sufficient to form acetic acid, wherein the liquid reaction medium includes: a carbonylation catalyst selected from rhodium catalysts, iridium catalysts and palladium catalysts; from 1 wt. % to 14 wt. % water; and one or more, in-situ generated derivatives of the one or more additives and combinations thereof; wherein the one or more additives are independently selected from non-benzoyl containing pentavalent phosphine oxides, compound mixtures of at least four phosphine oxides and pentavalent aryl or alkaryl phosphine oxides including one or more benzoyl groups; and recovering acetic acid from the process. | 2015-09-03 |
20150246867 | PROCESS FOR HYDROGENATION OF ESTERS OF AROMATIC CARBOXYLIC ACIDS TO YIELD SATURATED HOMOLOGUES THEREOF - A process for the hydrogenation of substituted aromatic compounds, with particular reference to esters of aromatic carboxylic acids, for example of aromatic esters used commonly as plasticizers in polymers having wide commercial application (see, in particular, esters of phthalic acid and trimellitic acid). | 2015-09-03 |
20150246868 | FLAVOR AND FRAGRANCE FORMULATION (III) - The present invention relates to the use of specific organic compounds as flavor and fragrance material. Furthermore the invention relates to new specific organic compounds, as well as to flavor and fragrance formulations comprising at least one of the specific organic compounds. | 2015-09-03 |
20150246869 | Process for Preparing Cinacalcet and Pharmaceutically Acceptable Salts Thereof - The present patent application relates to a process for preparing, cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula all) in which R | 2015-09-03 |
20150246870 | CHROMIUM 4-HYDROXYISOLEUCINATE COMPOUND METHODS FOR PREPARTION AND USE - A dietary supplement that may include chromium 4-hydroxyisoleucinate. The chromium 4-hydroxyisoleucinate may be provided in a molar ratio between 1:5 and 5:1 ligand to metal. The dietary supplement may be used to manage blood glucose levels, to improve insulin resistance, and to improve glucose uptake. | 2015-09-03 |
20150246871 | PREPARATION OF AN INTERMEDIATE COMPOUND OF IOFORMINOL - The present invention relates to a process for the preparation of iodinated X-ray contrast agents and in particular to key intermediates thereof. More particularly, the invention relates to a work-up process for preparation of a compound mixture comprising 1-formylamino-3,5-bis(2,3-bis(formyloxy)propan-1-ylcarbamoyl)-2,4,6-trioodobenzene, a key intermediate in the process for preparing Ioforminol. Further, the invention relates to a process for preparing Ioforminol, a contrast agent useful in X-ray imaging. | 2015-09-03 |
20150246872 | IMIDE COMPOUND, METHOD FOR MANUFACTURING SAME, AND USE AS INSECTICIDE - The invention provides an imide compound represented by the following Formula (1) and an insecticide including the imide compound: | 2015-09-03 |
20150246873 | METHOD FOR PRODUCING DIISOCYANATES BY PHOSGENATING DIAMINE SUSPENSIONS - The invention relates to a method for producing organic diisocyanates by reacting the corresponding diamines with phosgene in inert solvents. High-melting diamines from the series of 1,5-naphthalenediamine, tetralindiamine, 1,4-phenylenediamine, durenediamine, and o-tolidinediamine are used as diamines. According to the invention, a suspension of the diamines in inert solvents is produced, wherein dynamic mixing units, selected from dispersion disks and rotor-stator systems, are used, and the obtained suspension is phosgenated. | 2015-09-03 |
20150246874 | AMINOCARBONYLCARBAMATE COMPOUNDS - The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: | 2015-09-03 |
20150246875 | FLUOROSURFACTANTS - The present invention relates to novel compounds containing fluorinated end groups, to the use thereof as surface-active substances, and to compositions comprising these compounds. | 2015-09-03 |
20150246876 | HIGH-PURITY SODIUM P-STYRENESULFONATE WITH EXCELLENT HUE, METHOD FOR PRODUCING THE SAME, POLY (SODIUM P-STYRENESULFONATE) WITH EXCELLENT HUE USING THE SAME, AND DISPERSANT AND SYNTHETIC STARCH FOR CLOTHING FINISHING USING THE POLY ( SODIUM P-STYRENESULFONATE) - Provided are high purity sodium p-styrenesulfonate with an excellent hue which is useful as a reactive emulsifier or dispersant for producing a polymer emulsion, or synthetic starch for clothing ironing and poly(sodium p-styrene-sulfonate) with an excellent hue using the same or sodium p-styrenesulfonate improved in fluidity while keeping good solubility. | 2015-09-03 |
20150246877 | ARYL TETRAFLUOROSULFANYL COMPOUNDS - The invention provides compounds of the Formula (I), methods of making the compounds, and devices comprising the compounds. | 2015-09-03 |
20150246878 | MERCAPTO BENZOPHENONE COMPOUNDS, COMPOSITIONS AND PREPARATION METHOD THEREOF - The present invention provides a photocurable composition prepared using mercapto benzophenone compounds as key raw materials. The present invention aims to solve the problems existing in the prior photo-curing technology that low-molecular photoinitiators are easy to remain and migrate, while macromolecular photoinitiators has low initiation efficiency due to a low content of effective components and also has the problem of certain migration. The photocurable composition in the present invention can be easily prepared and has high addition efficiency with ethylenically unsaturated compounds, and the photocurable composition obtained by addition has no residual mercapto and has features of high initiation activity and zero migration rates when it is used in photocurable coatings, binder and ink formula. | 2015-09-03 |
20150246879 | Carbondisulfide Derived Zwitterions - Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability. | 2015-09-03 |
20150246880 | PROCESS FOR THE PREPARATION OF OPTIONALLY SUBSTITUTED PHENYL AND PYRIDYL PYRROLIDINES - The present invention relates to a method for the preparation of optionally substituted aryl and pyridyl pyrrolidines which are useful intermediates for the preparation of certain biologically active compounds. | 2015-09-03 |
20150246881 | Processes - The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, | 2015-09-03 |
20150246882 | INDOLINES - Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R | 2015-09-03 |
20150246883 | TERT-BUTYL N-[2-ETHYL]-L-ALANINATE OR A SALT, HYDRATE OR SOLVATE THEREOF - The present invention provides a compound which is: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alaninate or a salt, hydrate or solvate thereof. The present invention also provides a pharmaceutical composition comprising the compound together with one or more pharmaceutically acceptable carriers and/or excipients. The compound and composition are useful for inhibiting the activity of a p38 MAP kinase enzyme. As such they may be used in the treatment of a autoimmune or inflammatory disease, or a cell proliferative disease. In addition, the invention provides an acid produced by hydrolysis of the ester group of the compound of the invention. The acid is N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alanine. | 2015-09-03 |
20150246884 | PROCESS FOR PREPARING ROFLUMILAST - The invention relates to a process for the preparation of Roflumilast by reaction of an activated form of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid with an activating agent selected from (a) carbonyldiimidazole (CDI), (b) 1,1′-carbonyl-di-(1,2,4-triazol) (CDT), (c) 1,1′-carbonyl-bis-(2-methylimidazol), (d), 1′-carbonyl-dipyperidin, (e) N,N′-dicyclohexylcarbodiimide (DCC), (f) N,N′-diisopropylcarbodiimide (DIC), (g) 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and a combination of one of the previous (a)-(g) with (h) N-hydroxysuccinimide or (i) N-hydroxyphthalimide, and the subsequent reaction with 3,5-dichloropyridine-4-amine in the presence of an inorganic base. The invention also relates to the synthesis intermediates. | 2015-09-03 |
20150246885 | CERTAIN CHEMICAL ENTITES, COMPOSITIONS, AND METHODS - Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described. | 2015-09-03 |
20150246886 | Enhanced Erythropoiesis and Iron Metabolism - The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease. | 2015-09-03 |
20150246887 | ISOTHIOCYANATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF - Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth. | 2015-09-03 |
20150246888 | ENOYL REDUCTASE INHIBITORS WITH ANTIBACTERIAL ACTIVITY - Disclosed are compounds and compositions useful as antibacterials. In particular, disclosed are enoyl reductase (FabI) inhibitors, compositions comprising such compounds, processes for producing such compounds, and methods of using such compounds. | 2015-09-03 |
20150246889 | Benzimidazole Derivatives As PI3 Kinase Inhibitors - This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3Kβ selective benzimidazoles compounds for treating cancer. | 2015-09-03 |
20150246890 | SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH - Provided herein are diaminopyrimidyl Compounds having the following structures: | 2015-09-03 |
20150246891 | ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANCER DRUGS - A series of mono- and di-substituted quinazoline and pyrimidine derivatives based on the skeleton of erlotinib (an EGFR inhibitor) were synthesized and their bioactivities against hepatocellular carcinoma and human lung adenocarcinoma were evaluated. | 2015-09-03 |
20150246892 | N-SUBSTITUTED BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS - Disclosed are compounds of Formula (I): wherein: R | 2015-09-03 |
20150246893 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS - The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target. | 2015-09-03 |
20150246894 | NOVEL OXAZOLIDINONE COMPOUNDS - The invention provides compounds having the general formula I | 2015-09-03 |
20150246895 | CONTINUOUS PROCESS FOR PRODUCING EPICHLOROHYDRIN FROM GLYCEROL - A process for the continuous production, through the glycerine route, of epichlorohydrin from dichlorohydrins, in the presence of an alkali solution, wherein the reactive column for the reaction of dichlorohydrin to epichlorohydrin is characterized by single or multiple feed injections and by multiple alkali solution injections, in order to optimize the epichlorohydrin production and to minimize the aqueous effluents in quantity and in organic contaminants. | 2015-09-03 |
20150246896 | PROCESS FOR PRODUCING DIHYDRO-2H-PYRAN DERIVATIVES - Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R | 2015-09-03 |
20150246897 | Process for Manufacturing 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine - The invention discloses improved processes for manufacturing a compound, 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine, its monohydrochloride salt and intermediates thereof. | 2015-09-03 |
20150246898 | METALLOENZYME INHIBITOR COMPOUNDS - The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. Living organisms have developed tightly regulated processes that specifically import metals, transport them to intracellular storage sites and ultimately transport them to sites of use. One of the most important functions of metals such as zinc and iron in biological systems is to enable the activity of metalloenzymes. | 2015-09-03 |
20150246899 | PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF - The present invention relates to a process for the preparation of dabigatran etexilate. The present invention also relates to trifluoroacetate salt of dabigatran etexilate and a process for its preparation. The present invention further relates to crystalline Form I and crystalline Form II of trifluoroacetate salt of dabigatran etexilate and processes for their preparation. The present invention further relates to a process for the preparation of pharmaceutically acceptable salts, including methanesulfonate salt, of dabigatran etexilate. | 2015-09-03 |
20150246900 | Process for the Synthesis of Dabigatran and Its Intermediates - The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-I), a pharmaceutically acceptable salt for the treatment of thromboses, cardiovascular diseases etc. and intermediates involved in the synthesis. | 2015-09-03 |
20150246901 | MULTICOMPONENT CRYSTALLINE SYSTEM COMPRISING NILOTINIB AND SELECTED CO-CRYSTAL FORMERS - The present invention relates to crystalline materials comprising nilotinib and a carboxylic acid, carboxylic acid ester, carboxylic acid amide or sulfonic acid as a co-crystal former, and to pharmaceutical compositions comprising said materials. The invention also relates to processes for preparing said crystalline materials and to methods of using said crystalline materials to treat a disease condition in which tyrosine kinase inhibition is beneficial. | 2015-09-03 |
20150246902 | SUBSTITUED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES - The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. | 2015-09-03 |
20150246903 | Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid - Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract. | 2015-09-03 |
20150246905 | Slow Release of Organoboronic Acids in Cross-Coupling Reactions - A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: | 2015-09-03 |
20150246906 | NOVEL ACETAMIDE DERIVATIVES - The invention is concerned with a compound of formula (I) | 2015-09-03 |
20150246907 | PYRIDOMYCIN BASED COMPOUNDS EXHIBITING AN ANTITUBERCULAR ACTIVITY - Formula (1), X | 2015-09-03 |
20150246908 | KLF5 MODULATORS - The invention provides potent inhibitors of small molecule inhibitors of Krüppel-like factor 5 (KLF5) expression. Compounds of the invention are small molecule inhibitors of KLF5 expression which can be effective delay or prevent colon cancer onset, halt growth of existing tumors, and/or decrease reoccurrence. The compounds can be effective vs. many tumor types whose progression is in part mediated by KLF5, including colorectal cancers. Lowering KLF5 levels with an inhibitor of this invention may also impact other disease states, including diabetes, obesity, lipid homeostasis, cardiovascular disease, and arthritis. | 2015-09-03 |
20150246909 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity. | 2015-09-03 |
20150246910 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS - The present invention relates to compounds of Formula (I): | 2015-09-03 |
20150246911 | FUSED HETEROCYCLIC COMPOUND - This fused heterocyclic compound represented in formula (1) has excellent effectiveness in pest control. | 2015-09-03 |
20150246912 | Pyrrolo[3,2-C]Pyridine Tropomyosin-Related Kinase Inhibitors - The present invention relates to compounds of Formula (I) | 2015-09-03 |
20150246913 | BONE MARROW ON X CHROMOSOME KINASE (BMX) INHIBITORS AND USES THEREOF - The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the compounds of Formula (I) or (II), or compositions thereof, for treating or preventing a wide range of diseases (e.g., proliferative diseases (e.g., cancers, benign neoplasms, angiogenesis, inflammatory diseases, autoimmune diseases) and metabolic diseases (e.g., diabetes (e.g., type 2 diabetes, gestational diabetes)) in a subject. Treatment of a subject with a disease using a compound of Formula (I) or (II), or compositions thereof, may downregulate the expression and/or inhibit the activity of a kinase (e.g., a tyrosine kinase, such as a Tec kinase, in particular, bone marrow on X chromosome kinase (BMX)), and therefore, suppress tyrosine kinase singling in the subject. | 2015-09-03 |
20150246914 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES - Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. | 2015-09-03 |
20150246915 | [1,2,4]Triazolo[1,5-a]Pyridine and [1,2,4]Triazolo[1,5-c]Pyrimidine Compounds and Their Use - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc. | 2015-09-03 |
20150246916 | Substituted 6, 5-Fused Bicyclic Heteroaryl Compounds - The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 2015-09-03 |
20150246917 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. | 2015-09-03 |
20150246918 | IMIDAZOPYRIDINE DERIVATIVES - The invention is concerned with a compound of formula (I) | 2015-09-03 |
20150246919 | PYRIDINONES - The present invention encompasses compounds of general formula (I) | 2015-09-03 |
20150246920 | NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT - The present invention relates to novel crystalline forms of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g., NXL-104) thereof. The present invention relates to compositions comprising a crystalline form of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g., NXL-104) alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil). Processes for the preparation of the crystalline forms and methods of treating bacterial infections by administering the crystalline forms alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil) are also described. | 2015-09-03 |
20150246921 | STRONGLY FLUORESCENT HETEROCYCLES AND A METHOD FOR THEIR SYNTHESIS - This invention provides 1,4-dihydropyrrolo[3,2-b]pyrrole derivatives which can be used as strongly fluorescent compounds and a one-stage method for their synthesis from simple substrates. | 2015-09-03 |
20150246922 | PIPERAZINO[1,2-A]INDOL-1-ONES AND [1,4]DIAZEPINO[1,2-A]INDOL-1-ONE - The present invention relates to compounds of general formula I | 2015-09-03 |
20150246923 | 9H-PYRIMIDO[4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS - The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: | 2015-09-03 |
20150246924 | LIVER X RECEPTOR MODULATORS - Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described. | 2015-09-03 |
20150246925 | CDK Inhibitors - Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors. | 2015-09-03 |
20150246926 | CDK Inhibitors - Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors. | 2015-09-03 |
20150246927 | NOVEL SPIROOXINDOLE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME - Disclosed is a compound of formula I: wherein R | 2015-09-03 |
20150246928 | METHOD OF MAKING SULFIDE COMPOUNDS - According to one embodiment of the present disclosure, a method of making sulfide compounds using Scheme 1 | 2015-09-03 |
20150246929 | FUSED PYRIMIDINE COMPOUND, AND PREPARATION METHOD, INTERMEDIATE, COMPOSITION, AND USES THEREOF - Disclosed are a fused pyrimidine compound as represented by formula I, pharmaceutically acceptable salt, hydrate and solvate thereof, an optical isomer or a prodrug thereof, as well as a preparation method, an intermediate, a composition and uses thereof. The fused pyrimidine compound according to the present invention can inhibit activity of PI3 kinase, and can be used to treat diseases such as cancer caused by abnormal activity of the PI3 kinase, or can be used to prepare medicine for treating these diseases. | 2015-09-03 |
20150246930 | TRICYCLIC HETEROCYCLE COMPOUNDS - Disclosed are compounds of Formula (I), wherein: X is O or —NR | 2015-09-03 |
20150246931 | PROCESS FOR THE PREPARATION OF TAZOBACTAM - The present invention relates to an improved process for the preparation of Tazobactam of formula (I) having reduced content of cresol. | 2015-09-03 |
20150246932 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 2015-09-03 |
20150246933 | Compositions and Methods for Inhibiting Activity of Hypoxia-Inducible Transcription Factor Complex and Its Use for Treatment of Tumors - Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes. | 2015-09-03 |
20150246934 | TRICYCLIC GYRASE INHIBITORS - Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. | 2015-09-03 |
20150246935 | Process for Preparing of Bortezomib - The present invention provides improved processes for the preparation of Bortezomib, tert-butyl[1-({(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate of formula (IV) and N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl} phenylalanine of formula (V). Compound (IV) is prepared by coupling (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethyl-hexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butan-1-amine of formula (II) or its salt with N-(tert-butoxycarbonyl)-L-phenylalanine of formula (III) in a first solvent in the presence of a first coupling agent and a first base, wherein the coupling process does not comprise solvent exchange. Compound (V) is prepared by deprotecting compound (IV) using an alcoholic solution of an inorganic acid. | 2015-09-03 |
20150246936 | ISOCYANATOSILANES WITH THIOURETHANE STRUCTURE - The invention relates to a method for producing compounds containing isocyanate and silane groups by reacting at least A) one monomeric diisocyanate containing aliphatically, cycloaliphatically, araliphatically and/or aromatically bonded isocyanate groups with B) a mercaptosilane, characterised in that component A) is reacted with component B) in an equivalent ratio of isocyanate groups to mercapto groups of at least 06:01 to at most 40:1. Furthermore, the invention relates to the products which can be obtained using the method according to the invention, and to a composition containing compounds that contain isocyanate and silane groups. Moreover, the invention relates to the use of the products which can be obtained using the method according to the invention and the composition according to the invention as starting components in the production of silane group-containing polyurethanes, cross-linkable binders, varnish, and raw materials for sealants or adhesives. | 2015-09-03 |
20150246937 | ORGANOAMINOSILANES AND METHODS FOR MAKING SAME - Organoaminosilanes, such as without limitation di-iso-propylaminosilane (DIPAS), are precursors for the deposition of silicon containing films such as silicon-oxide and silicon-nitride films. Described herein are methods to make organoaminosilane compounds, or other compounds such as organoaminodisilanes and organoaminocarbosilanes, via the catalytic hydrosilylation of an imine by a silicon source comprising a hydridosilane. | 2015-09-03 |
20150246938 | NOVEL OLEFIN DERIVATIVE - The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound. | 2015-09-03 |
20150246939 | Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury - Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided. | 2015-09-03 |
20150246940 | CATALYST CAPABLE OF FORMING 2,5-DIMETHYLHEXENES - A process of making a catalyst and the catalyst composition made by that process comprising a multinuclear metal compound of the formula M | 2015-09-03 |
20150246941 | COBALT PRECURSORS FOR LOW TEMPERATURE ALD OR CVD OF COBALT-BASED THIN FILMS - Cobalt silylamide and cobalt carbonyl precursors are described, which are usefully employed in vapor deposition processes, such as chemical vapor deposition and atomic layer deposition, to deposit cobalt and to form high purity cobalt-containing films at temperatures below 400° C. These precursors and processes can be utilized in the manufacture of integrated circuitry and production of devices such as microprocessors, and logic and memory chips. | 2015-09-03 |
20150246942 | ALIGNMENT OF NANOMATERIALS AND MICROMATERIALS - The present invention provides a method for preparing a nanoassembly that includes the step of reacting the assembly template with at least one nanomaterial to form the nanoassembly using a bifunctional linker. | 2015-09-03 |
20150246943 | CRYSTALLINE POLYMORPHIC FORM OF ULIPRISTAL ACETATE - A novel crystalline polymorphic form of ulipristal acetate useful as an agent for preventing and/or treating uterine leiomyoma and as a contraceptive, and a process for producing the crystalline polymorphic form are provided. The novel crystalline polymorphic form of ulipristal acetate is obtained by crystallization or transition in association with a specified solvent. The solvent comprises at least one member selected from the group consisting of water, an aliphatic hydrocarbon, an aromatic hydrocarbon, a halogenated hydrocarbon, a linear alcohol, an alkyl ether, an acetate ester, an alkyl ketone, an N-alkylacylamide, and an alkanenitrile. | 2015-09-03 |
20150246944 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS - Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described. | 2015-09-03 |
20150246945 | PEPTIDES THAT BIND TO EPITHELIAL CELL ADHESION MOLECULE - [Problem to be Solved] | 2015-09-03 |
20150246946 | PEPTIDES AND METHODS FOR TREATING CANCER - By using a phage display derived peptide as an initial template, compounds have been developed that are highly specific against Mdm2/Mdm4. These compounds exhibit greater potency in p53 activation and protein-protein interaction assays than a compound derived from the p53 wild-type sequence. Unlike nutlin, a small molecule inhibitor of Mdm2/Mdm4, the phage derived compounds can arrest cells resistant to p53 induced apoptosis over a wide concentration range without cellular toxicity, suggesting they are highly suitable for cyclotherapy. | 2015-09-03 |
20150246947 | PEPTIDES AND METHODS OF USE - The invention provides peptides, including peptides that bind and, optionally, inhibit Protein S, and compositions thereof. The peptides may be used to, e.g., inhibit Protein S activity, enhance thrombin formation in a subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify Protein S, and identify a Protein S binding compound. | 2015-09-03 |
20150246948 | POLYPEPTIDES AND ANTIBODIES FOR TREATING HBV INFECTION AND RELATED DISEASES - The present invention relates to epitope peptides (or mutants thereof) for treating hepatitis B virus infection, recombinant proteins comprising such epitope peptides (or mutants thereof) and carrier proteins, and uses of such epitope peptides (or mutants thereof) and recombinant proteins. The present invention also relates to antibodies against such epitope peptides, cell lines producing said antibodies, and uses thereof. Furthermore, the present invention relates to vaccines or pharmaceutical compositions for treating or alleviating one or more symptoms associated with hepatitis B virus infection, which comprise the recombinant proteins or antibodies according to the invention, respectively. | 2015-09-03 |
20150246949 | Desmoglein 2 (DSG2) Binding Proteins and Uses Therefor - The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues. | 2015-09-03 |
20150246950 | Chimeric Dystrophin-VSV-G Protein to Treat Dystrophinopathies - A chimeric protein that is a fusion construct of a series of functional domains is used to deliver a therapeutic agent to a human subject suffering from disease. In some embodiments, the chimeric protein includes a therapeutic region, a transportation region, and a cleavage region disposed between the therapeutic region and the transportation region. The transportation region allows the chimeric protein to be moved across a cellular membrane of an affected cell within the subject. Cleavage of the chimeric protein at the cleavage region once within the cell separates the therapeutic region from the transportation region, enabling the therapeutic region to function normally within the cell. The therapeutic region can be effective in the treatment of, for example, muscular dystrophy, diastrophic dysplasia, malignant melanoma, porphyria, alpha-1 antitrypsin deficiency, Aicardi-Goutieres syndrome, cystic fibrosis, progeria, Marfan syndrome, tuberous sclerosis, adrenoleukodystrophy, and the like. | 2015-09-03 |
20150246951 | LOCALIZATION AND CHARACTERIZATION OF FLAVIVIRUS ENVELOPE GLYCOPROTEIN CROSS-REACTIVE EPITOPES AND METHODS FOR THEIR USE - Disclosed herein is a method for identifying | 2015-09-03 |
20150246952 | MEANS AND METHODS FOR BREAKING NONCOVALENT BINDING INTERACTIONS BETWEEN MOLECULES - Described are multimeric proteinaceous molecules comprising at least two members that bind each other via a region of noncovalent interaction, wherein a first of the members comprises a conditionally reactive group that, when activated, cleaves a covalent bond within the first member. Cleavage of the covalent bond results in a reduction in the binding strength with which the at least two members bind to each other via the region of noncovalent interaction. The reduction in the binding strength can result in the separation of the members under mild conditions. | 2015-09-03 |
20150246953 | IMMUNOGLOBULJIN-BINDING HUMAN MYCOPLASMA ANTIGENS AND METHODS OF USE THEREOF - Provided herein methods of alleviating the symptoms of multiple myeloma in a patient or subject in need thereof, methods of treating multiple myeloma in a patient or subject, and methods of preventing development of multiple myeloma in a patient at risk thereof, such as a patient with monoclonal gammopathy of undetermined significance (MGUS), which methods include administering an agent effective to treat a | 2015-09-03 |
20150246954 | INSECTICIDAL PROTEINS DERIVED FROM BACILLUS THURINGIENSIS - The present invention relates to the field of plant pest control, particularly insect control. Provided are nucleotide sequences from | 2015-09-03 |
20150246955 | METHODS AND COMPOSITIONS FOR SPECIFIC MODULATION OF MCL-1 - A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death. | 2015-09-03 |
20150246956 | USE OF IL-15 PREPARATIONS TO TREAT LYMPHOPENIA - The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with supraphysiological levels of interleukin (IL)-15. The present invention also provides methods for preventing, alleviating, reducing, and/or inhibiting lymphopenia or peripheral depletion of lymphocytes in a patient in need thereof by administering to the patient IL-15. | 2015-09-03 |
20150246957 | PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS AND MAKING AND USING THEREOF - Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate de novo bone turnover and stimulate bone fracture repair. | 2015-09-03 |
20150246958 | BIOREVERSABLE PROMOIETIES FOR NITROGEN-CONTAINING AND HYDROXYL-CONTAINING DRUGS - Disclosed are promoieties of the following formula which can be used to form prodrugs of nitrogen-containing or hydroxyl-containing drug or a pharmaceutically active agent: | 2015-09-03 |