35th week of 2015 patent applcation highlights part 9 |
Patent application number | Title | Published |
20150238593 | MVA EXPRESSING MODIFIED HIV ENVELOPE, GAG AND POL GENES - The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes. | 2015-08-27 |
20150238594 | IMMUNOGENS OF HIV-1 BROADLY NEUTRALIZING ANTIBODIES, METHODS OF GENERATION AND USES THEREOF - The present application relates to immunogens of broadly neutralizing monoclonal antibodies specific for HIV-1, such as broad and potent neutralizing monoclonal antibodies specific for HIV-1 and their gernation and methods of use. Broad neutralization suggests that the antibodies can neutralize HIV-1 isolates from different individuals. Immunogens or vaccines which may elicit such antibody associated responses are useful in pharmaceutical compositions for the prevention and treatment of HIV, and for the diagnosis and monitoring of HIV infection. | 2015-08-27 |
20150238595 | CONSTRUCTS FOR ENHANCING IMMUNE RESPONSES - Chimeric protein constructs including a herpesvirus glycoprotein D (gD) and a heterologous polypeptide that interact with herpes virus entry mediator (HVEM) and enhance and enhance an immune response against the heterologous polypeptide and methods for their use are provided. | 2015-08-27 |
20150238596 | BIOCONJUGATES COMPRISING MODIFIED ANTIGENS AND USES THEREOF - Provided herein is a bioconjugate comprising a carrier protein and a modified antigen of | 2015-08-27 |
20150238597 | CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES - The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines. | 2015-08-27 |
20150238598 | PHARMACEUTICAL COMPOSITION COMPRISING A SOLID NANOPARTICLE AND AT LEAST AN ANTIGEN FOR THE TREATMENT AGAINST AN INTRACELLULAR PATHOGENIC AGENT - A pharmaceutical composition for its use in the prophylactic treatment in a patient against an intracellular pathogen, said composition comprising a solid nanoparticle comprising a porous cationic-polysaccharide solid core, loaded with at least an anionic phospholipid without being surrounded by any phospholipidic layer and at least an antigen obtained from said pathogen. | 2015-08-27 |
20150238599 | NONSPECIFIC IMMUNOSTIMULATOR COMPOSITION, METHOD OF PREPARATION THE SAME, AND ITS USE - Disclosed are a nonspecific immunostimulant composition, a preparation method thereof, and uses thereof. The composition includes 150 to 300 wt. parts of sodium silicate, 2˜8 wt. parts of sodium thiosulfate, 0.5˜2 wt. parts of sodium carbonate, 0.5˜2 wt. parts of potassium chloride, 200˜400 wt. parts of white sugar, and 300˜400 wt. parts of water, based on 100 wt. parts of potassium carbonate. The composition exhibits excellent defense against the mortality caused by AIV H5N1, thus improving the survival of infected animals. As a supplement of a formulated feed mixture for farmed aquatic organisms, the composition provides excellent immunostimulation and disease resistance so as to decrease the mass mortality of aquatic organisms and to increase productivity. Particularly, when raised with a food in mixture with the composition, livestock and farmed aquatic organisms are immunologically improved so that they can endure and are protected against epidemic diseases caused by viruses and bacteria. | 2015-08-27 |
20150238600 | Immunostimulating Polyphosphazene Compounds - Polyphosphazene polymers having immunomodulating activity, and the biomedical use of such polyphosphazene polymers, in conjunction with an antigen or an immunogen are disclosed. | 2015-08-27 |
20150238601 | TREATMENT OF OCULAR DISORDERS - The invention provides methods of treatment of ocular disorders, including ocular disease with an angiogenic component. In certain embodiments, the treatment comprises administration of a ROCK2 inhibitor and an angiogenesis inhibitor. In certain embodiments, the ROCK2 inhibitor is ROCK2 selective. In certain embodiments, the angiogenesis inhibitor is a VEGF antagonist, for example, and VEGFR2 antibody. | 2015-08-27 |
20150238602 | COMBINATION THERAPIES AND USES FOR TREATMENT OF DEMYELINATING DISORDERS - Methods and compositions for enhancing one or more of: myelination, re-myelination, oligodendrocyte numbers, or neuroaxonal protection, while ameliorating an inflammatory condition in a human subject are disclosed. In certain embodiments, the methods and compositions described herein include a reparative agent (e.g., a LINGO-1 antagonist) and an immunomodulatory agent, in combination. Thus, methods, compositions and kits described herein can be useful for treating a CNS demyelinating disease. | 2015-08-27 |
20150238603 | COMBINATIONS AND USES THEREOF - The present disclosure describes a pharmaceutical combination of an anti-CD38 antibody and melphalan. | 2015-08-27 |
20150238604 | CD47 ANTIBODIES AND METHODS OF USE THEREOF - This invention relates generally to monoclonal antibodies that recognize CD47, more specifically to CD47 antibodies that do not cause a significant level of agglutination of cells, to methods of generating these antibodies, and to methods of using these monoclonal antibodies as therapeutics. | 2015-08-27 |
20150238605 | SEMIFLUORINATED ALKANE COMPOSITIONS - The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions. | 2015-08-27 |
20150238606 | PHARMACEUTICAL COMPOSITION CONTAINING LULICONAZOLE - Means for controlling the formation amount of a formed amide form in relation to a pharmaceutical composition containing luliconazole is provided. Disclosed is a pharmaceutical composition containing 1) luliconazole and 2) one component or two or more components selected from carboxylic acid and derivative thereof, ketone, phosphoric acid and derivative thereof, local anesthetic, antihistamine, and POE-based nonionic surfactant; wherein a content of an amide derivative of luliconazole is not more than 0.2% by mass with respect to a charged amount of luliconazole after storage at 60° C. for 3 weeks or at 40° C. for 6 months. | 2015-08-27 |
20150238607 | PHARMACEUTICAL PREPARATION COMPRISING AMINOPYRAZOLE DERIVATIVE - The pharmaceutical formulations according to the present invention include an alkyl sulfate salt and a compound represented by general formula (I) below (where R | 2015-08-27 |
20150238608 | METHODS OF DELIVERING STABLE TOPICAL DRUG COMPOSITIONS - A method of delivering a drug composition comprises providing a carrier having a phosphatidylcholine component and a drug entrapped therein, and applying the composition to the skin for transdermal delivery of the drug, wherein the composition is stable at room temperature. | 2015-08-27 |
20150238609 | LIQUID CONCENTRATED VITAMIN E COMPOSITIONS - The present patent application relates to liquid concentrated vitamin E (and/or vitamin E derivatives) compositions. The liquid composition comprises vitamin E (and/or vitamin E derivatives) and at least 40 wt-% of at least one polyoxyethylene sorbitan monofatty acid ester and said liquid composition has an IU value of at least 0.30 IU/mg (based on the total weight of the liquid composition). Furthermore the present invention is related to the use of such compositions in liquid formulations (especially beverages, such as soft drinks), which are transparent (even after pasteurization). | 2015-08-27 |
20150238610 | EXCIPIENTS FOR USE IN ADENO-ASSOCIATED VIRUS PHARMACEUTICAL FORMULATIONS, AND PHARMACEUTICAL FORMULATIONS MADE THEREWITH - Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise recombinant AAV virions in combination with one or more dihydric or polyhydric alcohols, and, optionally, a detergent, such as a sorbitan ester. Also described are methods of using the compositions. | 2015-08-27 |
20150238611 | BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF - Bolaamphiphilic compounds are provided according to formula I: | 2015-08-27 |
20150238612 | Medication With A Reduced Bitter Taste Perception - A liquid medication with reduced bitterness containing a drug active and polyquaternium-2, polyquaternium-17, and/or polyquaternium-18. | 2015-08-27 |
20150238613 | Compositions With Reduced Bitter Taste Perception - A composition with reduced bitterness containing polyquaternium-2, polyquaternium-17, and/or polyquaternium-18. | 2015-08-27 |
20150238614 | STABILISED AMORPHOUS FORM OF AGOMELATINE, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT - Stabilised amorphous form of the compound of formula (I): | 2015-08-27 |
20150238615 | Denaturants for sympathomimetic amines - There are provided pharmaceutical compositions comprising a sympathomimetic amine, one or more amino polymers and one or more enteric polymeric compounds insoluble in water at pH below 5.5 the combination of which acts both to interfere with the isolation of the sympathomimetic amine from the composition and to interfere with the conversion of the sympathomimetic amine to another pharmacologically active compound, all of said components being well mixed with each other. | 2015-08-27 |
20150238616 | SOLID PREPARATION COMPRISING ENTERIC SOLID DISPERSION - Provided are a solid preparation comprising an enteric solid dispersion that allows a drug in the preparation to be rapidly dissolved without impairing the dissolution of the solid preparation, and a method for producing the same. More specifically, provided are a solid preparation comprising a poorly soluble drug, an enteric polymer, an excipient and a disintegrator, a mixed powder comprising at least the excipient and the disintegrator is partly or entirely covered with a solid dispersion comprising the poorly soluble dug and the enteric polymer; and a method for producing a solid preparation, comprising steps of: spraying an enteric polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a mixed powder comprising an excipient and a disintegrator; and granulating and drying a resultant. | 2015-08-27 |
20150238617 | SILK RESERVOIRS FOR SUSTAINED DELIVERY OF ANTI-CANCER AGENTS - The present invention on directed to silk-based drug delivery compositions for sustained delivery of drugs, e.g., for cancer therapy, and methods of their use for treatment. | 2015-08-27 |
20150238618 | FATTY ACID FUMARATE DERIVATIVES AND THEIR USES - The invention relates to Fatty Acid Fumarate Derivatives; compositions comprising an effective amount of a Fatty Acid Fumarate Derivative; and methods for treating or preventing cancer, a metabolic disorder or neurodegenerative disorder comprising the administration of an effective amount of a Fatty Acid Fumarate Derivative. | 2015-08-27 |
20150238619 | POLYMERIC CARRIER - Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g., oligonucleotides) and/or other therapeutic agents into a living cell. | 2015-08-27 |
20150238620 | Compositions and Methods for Administering Insulin or Insulin-Like Protein to the Brain - The present invention provides a method of intranasal delivery of a pharmaceutical composition, comprising a polysaccharide derivative of insulin protein and a one or more pharmaceutically acceptable excipients, to a subject, wherein the insulin protein is delivered to the brain of the subject through the nasal mucosa. | 2015-08-27 |
20150238621 | Compounds and Methods for Targeted Immune System Delivery - Compounds and methods for targeted immune system delivery are disclosed. Pharmaceutical compositions including the disclosed compounds and a pharmaceutically acceptable excipient are also disclosed. Methods of targeted delivery to an antigen-presenting cell, and methods of treating or preventing a disease or condition susceptible to treatment by immunomodulation are disclosed. | 2015-08-27 |
20150238622 | BORON CLUSTER-MODIFIED PEG LIPID DERIVATIVE, AND MOLECULAR ASSEMBLY USING SAME - The present invention provides a novel boron carrier compound that can be used for boron neutron capture therapy for cancer, and that can realize improvement in the efficiency of a Drug Delivery System (DDS) and an increase in the boron concentration in a tumor. The present invention provides a boron cluster-modified PEG lipid derivative represented by Formula (I): | 2015-08-27 |
20150238623 | Dendrimers, Conjugates and Methods Thereof - The present disclosure relates to dendrimers composed of a hetero-bifunctional moiety and an aromatic heterocycle and to methods of synthesizing said dendrimers. The present disclosure also relates to dendrimer-bioactive molecule conjugates, the process of synthesizing the conjugates and pharmaceutical compositions comprising said conjugates. The dendrimer in the conjugates acts as a carrier and significantly increases the therapeutic efficacy of the bioactive molecule. | 2015-08-27 |
20150238625 | HYDROGEL FORMULATIONS - A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety. | 2015-08-27 |
20150238626 | RECEPTOR LIGAND LINKED CYTOTOXIC MOLECULES - The present invention refers to neuropeptide Y receptor 1 (NPY-1) binding ligands linked to cytotoxic molecules and their use for the treatment of cancer and other diseases. | 2015-08-27 |
20150238627 | PEPTIDE-LINKED MORPHOLINO ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF MYOTONIC DYSTROPHY - Provided herein are peptide-linked morpholino (PPMO) antisense oligonucleotides that target the poly CUG repeat tract in the 3′ untranslated region of the gene encoding dystrophia myotonica-protein kinase (DMPK) and methods for systemic administration of the same for the treatment of mytonic dystrophy type I (DM1). | 2015-08-27 |
20150238628 | ANTI-THEOPHYLLINE ANTIBODIES AND METHODS OF USE - The invention provides anti-theophylline antibodies and methods of using the same. | 2015-08-27 |
20150238629 | LIQUID FORMULATION OF LONG ACTING INSULINOTROPIC PEPTIDE CONJUGATE - The present invention relates to a liquid formulation of long-acting insulinotropic peptide conjugate, comprising a pharmaceutically effective amount of long-acting insulinotropic peptide conjugate consisting of a physiologically active peptide, insulinotropic peptide, and an immunoglobulin Fc region; and an albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent, and a method for preparing the formulation. For the purpose of preventing microbial contamination, a preservative may be added. The liquid formulation of the present invention is free of human serum albumin and other potentially hazardous factors to body, having no risk of viral contamination, and thus can provide excellent storage stability for insulinotropic peptide conjugates at high concentration. | 2015-08-27 |
20150238630 | Compositions and Methods for Antigen Targeting to CD180 - The present limiting provides compositions of CD 180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease. | 2015-08-27 |
20150238631 | CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF - Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain (TID). The switch may further comprise a linker. Further disclosed herein are methods of using the switches for the treatment of one or more conditions or diseases in a subject in need thereof. | 2015-08-27 |
20150238632 | Compositions and Methods for Delivery of Antigens to Plasmacytoid Dendritic Cells - The present invention provides compositions of blood dendritic cell antigen 2 (BDCA2) targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease. | 2015-08-27 |
20150238633 | ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 158P1D7 PROTEINS - Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer. | 2015-08-27 |
20150238634 | Inclusion Compounds of Fumagillol Derivative or its Salt, and Pharmaceutical Compositions Comprising the Same - The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis. | 2015-08-27 |
20150238635 | Indirect Chromoendoscopy with an Oral Indigo Carmine Base Preparation - Indirect chromoendoscopy is performed by providing a subject with an orally administered composition which includes indigo carmine dye mixed with polyethylene glycol (PEG). Preferably, the subject ingests at least 160 mg of indigo carmine prior to the endoscopic procedure. This is accomplished by ingesting 1 ml to 6 L of a premixed or reconstituted indigo carmine and PEG composition up to twenty four hours prior to the endoscopic procedure. | 2015-08-27 |
20150238636 | Engineered Particles with Polarization Contrast and Alignment Control for Enhanced Imaging - An engineered particle for detecting analytes in an environment includes an electromagnetic receiver that is configured to preferentially receive electromagnetic radiation of a specified polarization relative to the orientation of the electromagnetic receiver. The engineered particle additionally includes an energy emitter coupled to the electromagnetic receiver such that a portion of electromagnetic energy received by the electromagnetic receiver is transferred to and emitted by the energy emitter. The engineered particles are functionalized to selectively interact with an analyte. The engineered particle can additionally be configured to align with a directed energy field in the environment. The selective reception of electromagnetic radiation of a specified polarization and/or alignment with a directed energy field can enable orientation tracking of individual engineered particles, imaging in high-noise environments, or other applications. A method for detecting properties of the analyte of interest by interacting with the engineered particle is also provided. | 2015-08-27 |
20150238637 | Blood-brain Barrier Epitopes and Uses Thereof - The invention features a method of identifying an agent and generating an antibody that can cross the blood brain barrier, through the use of novel antigen isoforms of transmembrane domain protein 30A (TMEM30A). This is useful in establishing mechanisms of transmigration across the blood-brain barrier. These antigens are enriched in brain endothelium compared to other endothelial cells and may have better selectivity and capacity for brain delivery compared to transferrin and insulin receptors. One antigen is TMEM30A. | 2015-08-27 |
20150238638 | COATED UP-CONVERSION NANOPARTICLES - The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising α-Na Ln | 2015-08-27 |
20150238639 | Contrast Agent and Applications Thereof - A reagent comprising a nanodiamond particle linked to a paramagnetic ion for use as a contrast agent in magnetic resonance (MR) imaging in which T2-weighted magnetic images are obtained, and in particular in which both T1- and T2-weighted magnetic images are obtained, are described and claimed. Also claimed are novel reagents of this type, methods for their preparation and their use in diagnostics. | 2015-08-27 |
20150238640 | METHOD FOR PREPARING A MARKED PURINE DERIVATIVE, SAID DERIVATIVE AND USES THEREOF - The present invention relates to a method for preparing a 2-fluoropurine marked with the radioisotope | 2015-08-27 |
20150238641 | COMPOSITIONS TARGETING BRADYKININ RECEPTOR B1 FOR MEDICAL IMAGING OF CANCER AND OTHER DISORDERS - Bradykinin B1 receptor (B1R) targeting peptides and compounds are radiolabelled with radioisotopes that are suit-able for imaging and/or radiotherapy. Said radiolabelled peptides and compounds have utility in imaging tissues expressing or over expressing B1R and/or treating diseases or conditions in which B1R is expressed or overexpressed, including cancer. | 2015-08-27 |
20150238642 | Method and System to Clean Microorganisms without Chemicals - A system for removing microorganisms from a surface is described. The system includes a conducting member, a voltage source, and an electrostatic field controller. The conducing member includes a nonwoven material incorporating conductive fibers. The controller is electrically connected to the conducting member and is configured to apply a DC voltage of about 15 volts or less to the conducting member via the voltage source. The surface to be contacted can include any surface present in households, food industry facilities, medical facilities, etc. Such surfaces can include tables, countertops, walls, cabinets, doors, door handles, door knobs, etc. The system can also be used to treat devices used in the aforementioned environments, such as food preparation equipment, medical devices, household appliances, etc. The system can reduce the amount of microorganisms on the surface by at least about 1 log (90%) without the use of chemicals, high voltages, or long exposure times. | 2015-08-27 |
20150238643 | APPARATUS AND METHOD FOR THE STERILIZATION OF CONTAINERS - A sterilization device has a rod-like body which is capable of being introduced through an aperture into an interior space of containers and which acts upon an inner wall of the containers with radiation. A lifting cam produces a movement in a longitudinal direction, of the containers between the containers and the sterilization device in such a way that the containers are capable of being guided over the rod-like body. A movement device is provided which is capable of producing a relative movement in the longitudinal direction of the containers between the rod-like body and the lifting cam and of altering a relative distance between the lifting cam and the rod-like body. | 2015-08-27 |
20150238644 | HOME APPLIANCE INCLUDING PHOTOCATALYST FOR VISIBLE RAYS - A home appliance is provided that may include a photocatalyst for visible rays. The home appliance may include a case that defines an exterior, and a photocatalyst disposed on an inner or outer surface of the case. The photocatalyst may react or be activated by light having a visible-ray wavelength. Silver phosphate (Ag | 2015-08-27 |
20150238645 | Ultraviolet Illuminator - A solution for disinfecting an area using ultraviolet radiation is provided. The solution can include an enclosure including at least one ultraviolet transparent window and a set of ultraviolet radiation sources located adjacent to the at least one ultraviolet transparent window. The set of ultraviolet radiation sources can be configured to generate ultraviolet radiation directed through the at least one ultraviolet transparent window. An input unit can be located on the enclosure and configured to generate an electrical signal in response to pressure applied to the enclosure. A control unit can be configured to manage the ultraviolet radiation by monitoring the electrical signal generated by the input unit and controlling, based on the monitoring, the ultraviolet radiation generated by the set of ultraviolet radiation sources. | 2015-08-27 |
20150238646 | METHOD FOR CLEANING, DISINFECTING AND/OR STERILISING PACKAGING MEANS AND/OR COMPONENTS IN CONTAINER TREATMENT SYSTEMS - A method for treating a structure includes cleaning, disinfecting, or sterilizing the structure. The structure can be a food package, or a critical region of a system component of a container treatment system. Treating the structure includes treating it with an aqueous solution of chlorine dioxide having a chlorine dioxide concentration that is between 0.4 ppm-0.8 ppm. | 2015-08-27 |
20150238647 | VOLATILE SUBSTANCE DELIVERY SYSTEM - A volatile substance delivery system includes a volatile substance container to contain a volatile substance, an outlet to deliver a volume of the volatile substance from the volatile substance container to an ambient environment, and a manual screw pump to increase pressure within the volatile substance container and promote the delivery of the volatile substance from the volatile substance container. | 2015-08-27 |
20150238648 | SILVER-COPPER-ZINC OXIDE WOUND CARE SYSTEM - A wound care system for promoting wound healing and for preventing infections thereof and a method for producing the same includes an anti-microbial solution and a multi-layer wound dressing. The anti-microbial solution contains a mixture of colloidal silver, colloidal copper and colloidal zinc mixed in sterile purified water. The multi-layer wound dressing is formed of a contact layer, an intermediate layer, and an outer layer. The solution is poured onto the wound dressing which is subsequently placed directly over a wound so as to provide and maintain a moist environment. | 2015-08-27 |
20150238649 | ABSORBENT ARTICLE - An individually packaged absorbent article has a pair of flaps for securing the absorbent article to clothing of a wearer. The absorbent article is folded multiple times along multiple folding axes such that the pair of flaps is folded over a liquid-permeable top sheet and the top sheet faces inward. The top sheet has a blood lubricating agent containing region, which contains a predetermined blood lubricating agent, in an area which overlaps with the pair of flaps in the thickness direction of the absorbent article. Moreover, the absorbent article is provided with a spacer for forming a space between the pair of flaps and the blood lubricating agent containing region of the top sheet. | 2015-08-27 |
20150238650 | ABSORBENT MATERIALS, PRODUCTS INCLUDING ABSORBENT MATERIALS, COMPOSITIONS, AND METHODS OF MAKING ABSORBENT MATERIALS - In various exemplary embodiments described herein, an absorbent structure (e.g., a paper material) having an applied absorbent material (e.g., an absorbent film) may be formed by treating a fiber (e.g., a cellulosic fiber) with an applied absorbent material forming system (also referred to as a “film forming system”), absorbent materials, compositions, methods of making absorbent materials, and the like. | 2015-08-27 |
20150238651 | Pressure Sensitive Adhesive Compositions Containing Plant and Animal Butters - The present invention relates to an adhesive composition applicable to skin comprising a shea butter and /or at least one homopolymer, and/or copolymer. This invention also relates to a medical adhesive device and cosmetic adhesive applications including such adhesive composition. | 2015-08-27 |
20150238652 | VISCOUS HAEMOSTATIC COMPOSITIONS AND METHOD OF TREATMENT - A method of promoting haemostasis in a patient is provided by the administration, to the site of blood loss, of a viscous thixotropic haemostatic composition comprising an ionic precipitating agent, a fatty alcohol, an alcohol phosphate diester and one of an alkoxyether phosphate or a monoester phosphate of an alkoxylated fatty alcohol. | 2015-08-27 |
20150238653 | MEDICAL IMPLANT COMPRISING A BIODEGRADABLE MAGNESIUM-BASED ALLOY AND METHOD FOR ITS MANUFACTURE - A medical implant comprises a biodegradable magnesium-based alloy of which at least a part of its surface layer comprises a magnesium carbonate. A method for the manufacture of a biocompatible, corrosion-inhibiting protective surface layer on a medical implant comprising a magnesium-based alloy, comprises: providing an implant comprising a magnesium-based alloy to be coated; placing the implant into a reactor chamber; exposing at least part of the surface of said implant to an atmosphere comprising humid carbon dioxide to produce a coating on the surface of the implant comprising a magnesium carbonate of the formula | 2015-08-27 |
20150238654 | IRRIGATION RESISTANT COMPOSITIONS FOR REGENERATION OF HARD TISSUES AND METHODS AND KITS OF USING THE SAME - An irrigation resistant bone repair composition including a biocompatible or bioactive bone repair material and at least one non-ionic surfactant, other than a non-random poly(oxyalkylene) block copolymer, is described. Also, methods for treating a bone having a bone gap or a bone defect with the composition including a biocompatible or bioactive bone repair material and at least one non-ionic surfactant, other than a non-random poly(oxyalkylene) block copolymer, are also provided. Also, kits including the irrigation resistant bone repair composition including a biocompatible or bioactive bone repair material and at least one non-ionic surfactant, other than a non-random poly(oxyalkylene) block copolymer, are described. | 2015-08-27 |
20150238655 | MINERAL COATED SCAFFOLDS - Provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase. | 2015-08-27 |
20150238656 | ORGAN/TISSUE DECELLULARIZATION, FRAMEWORK MAINTENANCE AND RECELLULARIZATION - Methods for decellularizing organs and tissues in vitro and in vivo are provided, as are methods of maintaining organ and tissue frameworks and methods of recellularizing organs and tissues, thereby providing an approach to needed organs or tissues. | 2015-08-27 |
20150238657 | COMPOSITE TISSUE-ENGINEERED INTERVERTEBRAL DISC WITH SELF-ASSEMBLED ANNULAR ALIGNMENT - The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs. | 2015-08-27 |
20150238658 | Phospholipid Reduction in Biological Tissue - A method of reducing phospholipid concentration in biological tissue. The biological tissue is immersed in an isopropyl alcohol solution for an effective period of time. After the effective period of time, the biological tissue has a phospholipid concentration that is at least 10 percent by weight less than an initial phospholipid concentration of the biological tissue. | 2015-08-27 |
20150238659 | BIOPROSTHETIC TISSUE WITH REDUCED CALCIFICATION - A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization. | 2015-08-27 |
20150238660 | Porous Biomaterial - A synthetic osteoinductive porous biomaterial is provided comprising: a network of interconnected micropores, wherein the microporosity is 23% by volume or more; wherein the surface free energy of the biomaterial is 19 mJ/m or more; and the mean interconnection diameter and the mean interconnection diameter and the surface free energy are chosen to provide a permeability resulting from the micropores of 0.206 nm2 or greater and a capillary pressure difference in water of 3.7 kPa or more. The biomaterial contains hydroxyapatite and silicon. | 2015-08-27 |
20150238661 | FLEXIBLE AND/OR ELASTIC BRACHYTHERAPY SEED OR STRAND - A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible earner that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible. | 2015-08-27 |
20150238662 | SUSTAINED NITRIC OXIDE RELEASE COATING USING DIAZENIUMDIOLATE-DOPED POLYMER MATRIX WITH ESTER CAPPED POLY(LACTIC-CO-GLYCOLIC ACID) ADDITIVE - A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct. | 2015-08-27 |
20150238663 | DEVICE VIEWABLE UNDER AN IMAGING BEAM - The invention provides a stent made from a material operable to perform a stent's desired therapeutic functions, and also made from a material that has a radiopacity that substantially preserves the appearance of the stent when the stent is viewed under a CT imaging beam. Such a stent can allow for follow-up of the stent and the surrounding blood-vessel on CT. | 2015-08-27 |
20150238664 | ANTITHROMBOTIC MEDICAL MATERIALS AND MEDICAL APPARATUS USING THE SAME MATERIALS - A medical material that is excellent in antithrombogenicity even under a severe use condition in which thrombi are easily formed, is provided. The medical material contains a water-insoluble copolymer including a repeating unit (A) (which is derived from acryloylmorpholine, for example) and a repeating unit (B) (which is derived from methoxyethyl acrylate, for example), in which the water-insoluble copolymer has 5 mole % to 20 mole % of the repeating unit (A) with respect to all constituent units of the copolymer. | 2015-08-27 |
20150238665 | System and Method for Applying Reduced Pressure at a Tissue Site - The illustrative embodiments described herein are directed to a manually-actuated pump and method for applying reduced pressure at a tissue site. The manually-actuated pump includes at least one variable volume chamber that is manually compressible into a plurality of positions. The manually-actuated pump includes a fixed volume chamber in communication with the at least one variable volume chamber. The manually-actuated pump also includes a filter housing having a hydrophobic filter that prevents liquid from entering the at least one variable volume chamber. The fixed volume chamber is coupled to the at least one variable volume chamber via the filter housing. The filter housing is located in between the at least one variable volume chamber and the fixed volume chamber. The fixed volume chamber has reduced pressure that is applied to the tissue site in response to a movement of the at least one variable volume chamber from a compressed position in the plurality of positions to an uncompressed position in the plurality of positions. | 2015-08-27 |
20150238666 | SYSTEM FOR TISSUE DISSECTION AND ASPIRATION - A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes. A tool is provided to aspirate excess fluid and tissue from the treatment area. | 2015-08-27 |
20150238667 | Systems And Methods For Delivering Fluid To A Wound Therapy Dressing - Systems and methods for delivery of fluid to a wound therapy dressing. In exemplary embodiments, a pressure sensor measures the pressure at the wound therapy dressing and restricts fluid flow to the wound therapy dressing when a predetermined pressure is achieve. | 2015-08-27 |
20150238668 | Multi-Unit Blood Processor with Volume Prediction - Method and Apparatus for predicting the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags. | 2015-08-27 |
20150238669 | BREAST PUMP - The present application relates to a breast pump. The breast pump has a chamber ( | 2015-08-27 |
20150238670 | BREAST PUMP SYSTEM - The present application relates to an operating unit for a breast pump system. The operating unit comprises a housing and a vacuum pump received in said housing. The housing has a connector ( | 2015-08-27 |
20150238671 | BLOOD FLOW MANAGEMENT METHODS AND SYSTEMS - Methods and devices are provided for managing fluid flow through a body part, such as all or portions of an organ or extremity. In general, fluid inflow and fluid outflow vessels to at least a portion of a body part can be managed such that blood flow characteristics can be changed while maintaining, reducing, or increasing pressure of the associated flow. In some embodiments, pressure can be controlled while all fluid in at least a portion of the inflow and outflow vessels flows in an opposite direction. | 2015-08-27 |
20150238672 | SELF CALIBRATING BLOOD CHAMBER - An optical blood monitoring system and corresponding method avoid the need to obtain a precise intensity value of the light impinging upon the measured blood layer during the analysis. The system is operated to determine at least two optical measurements through blood layers of different thickness but otherwise substantially identical systems. Due to the equivalence of the systems, the two measurements can be compared so that the bulk extinction coefficient of the blood can be calculated based only on the known blood layer thicknesses and the two measurements. Reliable measurements of various blood parameters can thereby be determined without certain calibration steps. | 2015-08-27 |
20150238673 | Authentication and Tracking System - A dialysis authentication system comprising at least one dialysis component having at least one authentication component affixed thereon. The dialysis component can be any one of a dialyzer, sorbent cartridge, or recharger. The authentication component can be selected from the group comprising a radio-frequency identification marker, a bar code, a one-wire security component, and a wireless authentication component. | 2015-08-27 |
20150238674 | CONTROLLER FOR LIFE SUPPORT DEVICE AND CONTROL METHOD THEREOF - A controller for a life support device, the controller having a control section in charge of sequence control, the controller includes: a first interface section transmitting an output state of the control section to each part in the life support device, and transmitting an output state of each part in the life support device to the control section; and a second interface section setting an output state in response to detection of a predetermined data sequence output from the control section, and maintaining the set output state until the second interface section receives the predetermined data sequence anew. A part of the life support device is driven via the second interface section. | 2015-08-27 |
20150238675 | EXTRACORPOREAL BLOOD TREATMENT APPARATUS AND METHOD OF SETTING AN EXTRACORPOREAL BLOOD TREATMENT - It is described an extracorporeal blood treatment apparatus ( | 2015-08-27 |
20150238676 | PORTABLE HEMODIALYSIS MACHINE AND DISPOSABLE CARTRIDGE - A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialyzer, and a dialysate flow path and a blood flow path which flow in opposing directions through the dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate, and pressure and fluid flow sensors for measuring the pressure and fluid flow in the dialysate flow path and blood flow path. In addition, the disposable cartridge possesses pump actuators (but not pump motors) for pumping dialysate and blood through their respective flow paths. The reused dialysis machine possesses a reservoir for dialysate, a level sensor, a blood leak sensor, an ammonia sensor, a venous blood line pressure sensor, a venous blood line bubble detector, pump motors, and a processor connected to the motors and sensors for controlling and monitoring hemodialysis treatment. | 2015-08-27 |
20150238677 | PRESSURE DETECTION DEVICE OF LIQUID FLOW ROUTE - A pressure detection device of a liquid flow route includes; displacement detecting means that detects displacement of a peristaltically-actuated tube in the radial direction; pressure calculating means that is able to calculate blood removal pressure based on the displacement of the peristaltically-actuated tube; closed flow route forming means that is able to form a closed flow route which includes a portion at which the displacement detecting means is disposed; pressure changing means that is able to arbitrarily change the pressure in the closed flow route; pressure detection means that is able to detect pressure change in the closed flow route; and calibration curve acquiring means that is able to produce and acquire a calibration curve with which the displacement detecting means and the pressure calculating means are calibrated by a relationship between the pressure change detected by the pressure detection means and a detection value of the displacement detecting means. | 2015-08-27 |
20150238678 | PORTABLE HEMODIALYSIS MACHINE AND DISPOSABLE CARTRIDGE - A portable hemodialysis system is provided suitable for in home use. The hemodialysis system includes a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialyzer, and a dialysate flow path and a blood flow path which flow in opposing directions through the dialyzer. In addition, the disposable cartridge possesses pump actuators (but not pump motors) for pumping dialysate and blood through their respective flow paths. The pump actuators having non-deformable components including a housing having a central cavity forming an internal sidewall, a rotor eccentrically positioned within the cavity having radially aligned slots at the rotor's periphery, and vanes slideably positioned in the slots to slide in and out of the slots so as to seal with the cavity's internal sidewall creating vane chambers that pump blood or dialysate. | 2015-08-27 |
20150238679 | HEMODIALYSIS SYSTEM WITH CASSETTE-BASED BLOOD AND DIALYSATE PUMPING - A hemodialysis system includes: (i) a dialyzer; (ii) a dialysate source; a dialysate pump; (iii) a dialysate cassette operatively connected to the dialysate pump such that the dialysate pump can pump dialysate through the dialysate cassette when the dialysate cassette is in fluid communication with the dialysate source, the dialysate cassette in fluid communication with the dialyzer; (iv) a blood pump; and (v) a blood cassette separate from the dialysate cassette, the blood cassette operatively connected to the blood pump such that the blood pump can pump blood through the blood cassette, the blood cassette including a housing, the housing including a from-patient tube connector, a to-patient tube connector, a saline/priming tube connnector, a to-dialyzer tube connector, a from-dialyzer tube connector, and an internal air separation chamber. | 2015-08-27 |
20150238680 | DIALYSIS SYSTEM WITH ENHANCED FEATURES - A dialysis system includes a dialysis fluid cassette-based membrane blood pump; a dialyzer in fluid communication with the blood pump; first and second dialysis fluid cassette-based balance chambers each having (i) a fresh dialysis fluid compartment in fluid communication with the dialyzer and (ii) a spent dialysis fluid compartment; a dialysis fluid cassette-based fresh dialysis fluid membrane pump in fluid communication with the fresh dialysis fluid compartments of the first and second balance chambers; a dialysis fluid cassette-based spent dialysis fluid membrane pump in fluid communication with the dialyzer and the spent dialysis fluid compartments of the first and second balance chambers; and arterial and venous lines in fluid communication with the dialyzer for patient connection, the arterial and venous lines each including a contact used for electrically detecting a patient access disconnection. | 2015-08-27 |
20150238681 | APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A CONTROL METHOD THEREFOR - An apparatus is described for extracorporeal blood treatment ( | 2015-08-27 |
20150238682 | BODY-WALL-CONTACT-TYPE WATER TANK AND IN-CAVITY FLUID PERFUSION SYSTEM - A body-wall-contact-type water tank ( | 2015-08-27 |
20150238683 | CONTINUOUS AND CONTROLLED IRRIGATION SYSTEM - An irrigation system for providing a continuous and controlled flow of a fluid, wherein said irrigation system may include a reservoir system comprising a plurality of containers of fluid that are disposed in a predetermined radial configuration; said reservoir system has a main longitudinal axis; and a fluid transfer system in fluid connection with said reservoir system, said fluid transfer system comprising at least one fluid transfer head, adapted to transfer fluid from one of said plurality of containers to an external tubing system; wherein each of said fluid transfer heads has a mechanism adapted to radially move each of said fluid transfer heads around the main longitudinal axis and reach a position below each of the plurality of containers. | 2015-08-27 |
20150238684 | OVERTUBE AND USES THEREOF - Disclosed herein is an overtube for use with an irrigation tip of a catheter during wound irrigation. The overtube includes a tubular body, in which a portion of the tubular body is cut away; and the frontend of the tubular body is tapered in a direction that is away from the cut away portion of the tubular body and is at an angle about 130-180 degrees in relative to the tubular body. | 2015-08-27 |
20150238685 | Method and System for Enhanced Imaging Visualization of Deep Brain Anatomy Using Infusion - Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting. Ultimately this leads to reduced complications, enhanced therapy, and the elimination of the need for awake surgery. The method and system provides the capability heretofore not possible to visualize the small, often indistinct regions, which will greatly improve clinical outcomes with therapeutic interventions. | 2015-08-27 |
20150238686 | Disposable Multiuse Syringe Holder - The present invention is a disposable multiuse syringe holder and organizer which secures the syringes through the use of elastic pressure in its syringe holes or slots. It is a minimalist design which eliminates excess material both reducing material and fabrication costs. It is composed of a slightly elastic material such as foam board, cardboard, rubber, cork, corrugated plastic or other material with similar elastic properties. The device is intended to have a minimal footprint and the disposable nature of the device lends itself to be written on to indicate information about the syringes being held. An additional advantage in a standard rectangular configuration is that syringes held on the device can be stacked conveniently in a consecutively reversing formation. | 2015-08-27 |
20150238687 | Intraocular implant delivery apparatus and methods of use thereof - Apparatus and methods for introducing a solid or semi-solid intraocular drug-containing implant into the anterior chamber of an eye are described. The drug-containing implant can be a rod-shaped biodegradable implant that may provide for the extended release of the drug and may be effective for treating a medical condition of the eye. The apparatus is ergonomically designed in the shape or style of a pen with tactile surfaces for easy gripping, a needle-rotation knob to permit orientation of the needle bevel in relation to the eye, and a spring-actuated mechanism for consistent deployment of the implant. | 2015-08-27 |
20150238688 | OCCLUSION DETECTION FOR A FLUID INFUSION DEVICE - A device for delivering fluid to a user includes a housing, a drive motor assembly in the housing, a force sensor, and an electronics module. The drive motor assembly regulates delivery of fluid by actuating a piston of a fluid reservoir, and the force sensor generates output levels in response to force imparted thereto during, for example, fluid delivery operations. The electronics module processes the output levels of the force sensor to assess the operating health of the force sensor, to check for occlusions in the fluid delivery path, and to monitor the seating status of the fluid reservoir. | 2015-08-27 |
20150238689 | INFUSION PUMP - [Problem] Provided is an infusion pump in which a forward rotation and a reverse rotation of a rotor of a drive motor can be detected so as to be able to safely deliver drug to a patient. | 2015-08-27 |
20150238690 | INFUSION PUMP AND METHOD TO ENHANCE LONG TERM MEDICATION DELIVERY ACCURACY - An infusion pump is provided for pumping fluid though an administration set at a constant flow rate. The pump includes a pumping mechanism for pumping fluid and operates at a pulse frequency, and a controller controls the pulse frequency. Additionally, the pump has one or more sensors configured for measuring at least one characteristic value relating to a status of the infusion pump. The controller is configured for causing the pumping mechanism to operate at a first pulse frequency, and the one or more sensors measure the characteristic value. When the measured characteristic value meets a threshold value, the controller causes the pumping mechanism to operate at a second pulse frequency different from the first pulse frequency. | 2015-08-27 |
20150238691 | CONTROL SYSTEMS FOR RELEASE OF MEDICATION RESPONSIVE TO JOINT ACTIVITY - In some embodiments, a system for responsive release of a medicament in an artificial joint region includes: an implantable sensor unit including at least one sensor, the implantable sensor unit configured to be implanted in an artificial joint region; a responsive release control unit including an electronic controller and memory, the responsive release control unit configured to receive signals from the implantable sensor unit and to send signals to an implantable medicament release unit; and the implantable medicament release unit, including a reservoir and a controllable release unit attached to the reservoir, the controllable release unit configured to provide access to the reservoir in response to signals from the responsive release control unit, the implantable medicament release unit configured to be implanted in the artificial joint region. | 2015-08-27 |
20150238692 | DECISION SUPPORT SYSTEM USING INTELLIGENT AGENTS - A computing architecture, system and method are disclosed for use in a medical device for providing decision support to a caregiver. The computing architecture includes a memory, a processor in communication with the memory, and an instance of a primary rules-based service configured to provide instruction events, the instance providing a primary processing thread of instruction events for coaching treatment of a patient. A software manager module includes an artificial intelligence architecture. The artificial intelligence architecture is configured to provide an instance of a conditional rules-based service for providing instruction events. The instance provided by the artificial intelligence architecture provides a processing thread of instruction events for coaching treatment of a patient that is independent of the primary processing thread and is configured to trigger an action on the occurrence of a pre-defined set of input conditions. | 2015-08-27 |
20150238693 | POSTURE STATE DISPLAY ON MEDICAL DEVICE USER INTERFACE - The disclosure provides a system that displays a posture state indication to a user. A posture state indication represents the current posture state of the patient, which may be a combination of patient posture and activity. As a patient changes posture and activity throughout a daily routine, a posture state detector may generate a posture state value that may be used to categorize the patient's posture or posture and activity level as one of multiple posture states used to adjust therapy. The posture state may be associated with one of multiple posture state indications that may be presented to the patient. The posture state indication shows the patient the posture state currently detected by the posture state detector. The posture state indication may help the patient to effectively monitor therapy changes due to automatic, semi-automatic or patient-directed therapy adjustments made as a function of posture state. | 2015-08-27 |