35th week of 2009 patent applcation highlights part 42 |
Patent application number | Title | Published |
20090215097 | Novel Polymer and Method of Measuring Cholesterol Therewith - It is an object of the present invention to provide the method for determining cholesterol in lipoprotein and reagent for determining cholesterol comprising the polymer, and the present invention relates to the reagent for determining cholesterol in lipoproteins such as high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) and the determination method using the polymer comprising the following units as constituents: | 2009-08-27 |
20090215098 | QUANTIFICATION OF ENZYME ACTIVITY BY MASS SPECTROMETRY - The disclosure relates to methods of quantitatively analyzing the enzymatic activity of enzymes in samples containing a plurality of enzymes, using mass spectrometry. Isotopically labeled standards are employed. Purified enzymes and enzymes from crude cell lysates may be analyzed using the disclosed methods. As little as 0.02 pg of cell lysate may be detected. Also disclosed are kits for providing compositions so as to practice the disclosed methods. | 2009-08-27 |
20090215099 | METHOD OF IDENTIFYING CANCER BIOMARKERS AND CANCER PROGRESSION - An efficient method for identifying important cancer biomarkers and identifying progression of bladder cancer using pro-u-PA as a clinical tool is provided. Searching for biomarkers critical for bladder carcinoma diagnosis and prognosis, secreted proteomes of highly malignant U1 and pre-malignant U4 cell lines are first analyzed. Proteins in the cultured media of the U1 and U4 cell-lines were systematically examined by SDS-PAGE combined with MALDI-TOF mass spectrometry. Expression of pro-u-plasminogen activator (pro-u-PA) was confirmed by Western blot analysis and further evaluated. A statistically significant relationship between the low level and absence of pro-u-PA in urine with high stages and grades of the tumor samples was established. Constitutive expression of Ras dominant negative protein led to increased expression of pro-u-PA in cultured media, indicating the loss of pro-u-PA is associated with oncogenic transformation. The loss of pro-u-PA in urine has been identified as a marker of more advanced bladder carcinoma. | 2009-08-27 |
20090215100 | Process for producing sugar chain derivative, structure analysis method, and sugar chain derivative - A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity column chromatography. | 2009-08-27 |
20090215103 | GENERATION AND USE OF A CATALOG OF POLYPEPTIDE-RELATED INFORMATION FOR CHEMICAL ANALYSES | 2009-08-27 |
20090215104 | Bioreactor Device, and Method and System for Fabricating Tissues in the Bioreactor Device - A bioreactor device, and a method and system for fabricating tissues and growing cells and tissues in the bioreactor device, accommodates less than about 1 mL (or less than about 200 μL) of local medium volume but sample sizes of about 100 μL or greater. The bioreactor device includes a bioreactor chamber for containing a sample, where sample growth in response to mechanical, electrical, and biofactor stimulation is monitored through one or more optical ports. Embedded sensors are provided for measuring fluid pressure, pH, temperature, and oxygen tension. The bioreactor device can receive different types of mechanical loadings, including fluid shear, hydrostatic pressure, matrix compression, and clinorotation. | 2009-08-27 |
20090215105 | Tetraazaporphyrin-Based Compounds and Their Uses - Asymmetrically substituted metal-phthalocyanine compounds are disclosed. These compounds and other phthalo-cyanine-derivatives are used in bioimaging, bioanalysis, FRET and quenching techniques, photodynamic therapy, DNA analysis for cells, proteins, tissues and other biological entities, and other applications. Near-infrared fluorescence minimizes matrix effects typically seen in other methods of analyzing biochemical entities in cells, proteins, tissues and other biological entities. | 2009-08-27 |
20090215106 | METHOD FOR DETECTING INTRACELLULAR INTERACTION BETWEEN BIOMOLECULES - The present invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules, on living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair. | 2009-08-27 |
20090215107 | Activator for Transient Receptor Potential Vanilloid 2 Comprising Probenecids - The present invention relates to a method for activation of TRPV2 (transient receptor potential vanilloid 2) using probenecid, more precisely a method for selecting a candidate for TRPV2 blocker using probenecid. Probenecid of the present invention works on TRPV2 specifically so that it facilitates the isolation of sensory neurons expressing TRPV2. Therefore, probenecid of the invention can be effectively used for the studies on TRPV2 mechanisms and the development of a TRPV2 based anodyne. | 2009-08-27 |
20090215108 | Methods of analyzing a biological sample - Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens. | 2009-08-27 |
20090215109 | APPARATUS AND METHOD FOR MEASURING LUMINESCENCE AND FLUORESCENCE OF TRANSFECTED CELLS OR ORGAN PARTS - An apparatus for measuring photon emissions from marked cells. The apparatus has the following components: a rotatable, at least partly transparent growth chamber/bioreactor ( | 2009-08-27 |
20090215110 | WATER MONITORING SYSTEMS - The invention relates to a continuous water monitoring system, including components thereof, and a method relating thereto for continuously monitoring, in real-time, a water supply in order to detect contaminants therein. The system employs the use of a live culture of bioluminescent bacteria and suitable light detecting means. | 2009-08-27 |
20090215111 | ANALYSIS OF STEROID HORMONES IN THIN TISSUE SECTIONS - Mass-spectrometry based methods of analyzing estrogens and other steroids from biological tissue sections samples are disclosed herein. Methods of detecting a disease state or condition or elevated risk of a disease state or condition in a mammal from tissue sections are also disclosed. | 2009-08-27 |
20090215112 | Tissue Sample Preprocessing Methods and Devices - To preprocess a tissue sample, a first permeable mesh membrane is tautly stretched out over the tissue sample and overlaid on top of a flat surface. This covering sandwiches and secures the tissue sample in between the first permeable mesh membrane and the flat surface. If it is desired to reinforce the mechanical strength of the first permeable mesh membrane, a second permeable mesh membrane can be tautly stretched out and overlaid on top of the sandwich. Alternatively, the second permeable mesh membrane can be attached onto a third component, such as a disposable solvent resistant frame, to create a framed mesh. Thereafter, the first permeable mesh membrane may be attached to the framed mesh to create a compound framed mesh. The tissue sample may then be sandwiched and secured in between the compound framed mesh and the flat surface. To retain and flatten the tissue sample, gentle pressure may be uniformly applied. | 2009-08-27 |
20090215113 | Methods for purifying pertussis toxin and peptides useful therefor - The present invention relates to reagents and methods for purifying pertussis toxin (PT). | 2009-08-27 |
20090215114 | METHOD OF ENZYMATICALLY SYNTHESIZING 3' -PHOSPHOADENOSINE-5' -PHOSPHOSULFATE - The invention provides a method for producing 3′-phosphoadenosine 5′-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5′-triphosphate sulfurylase (ATPS) and adenosine 5′-phosphosulfate kinase (APSK), wherein an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and polyphosphate:AMP phosphotransferase (PAP), or an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and adenylate kinase (ADK) is employed instead of ATP. | 2009-08-27 |
20090215115 | SIALYLTRANSFERASES COMPRISING CONSERVED SEQUENCE MOTIFS - The present invention provides, e.g., sialyltransferase proteins comprising conserved sequence motifs, including α-2,3-sialyltransferase proteins from | 2009-08-27 |
20090215116 | Identification of a beta-1,3-N-acetylgalactosaminyltransferase (CGTE) from campylobacter jejuni LIO87 - The invention relates to β-1,3-N-acetylgalactosaminyltransferase polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides. | 2009-08-27 |
20090215117 | Site specific incorporation of keto amino acids into proteins - Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs. | 2009-08-27 |
20090215118 | D-AMINOACYLASE - A D-aminoacylase having a high substrate specificity is provided. This D-aminoacylase can produce D-amino acids from N-acetyl-D,L-amino acids conveniently and efficiently at a low cost. | 2009-08-27 |
20090215119 | METHODS FOR PRODUCING SPECIFIC BINDING PAIRS - Provided are improved methods for providing specific binding pairs (SBPs). The methods enable production of libraries of SBP members using both a large population of one member of the SBPs and a smaller, preselected population of the other member of the SBPs having affinity for a preselected target. | 2009-08-27 |
20090215120 | The Use of Protein S Fusion for Protein Solubilization - The invention provides vectors containing a multiple cloning site comprising a PrS tag or a PrS2 tag from | 2009-08-27 |
20090215121 | Process for Preparing High Levels of Interferon Beta - The present invention relates to a novel process for the production of interferon-beta in improved yields by fermentation. | 2009-08-27 |
20090215122 | Process for Producing Thioredoxin - An object of the present invention is to provide a process for conveniently and efficiently producing high purity thioredoxin from yeast. | 2009-08-27 |
20090215123 | Method for Producing Continuous Cell Lines - The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said cells with UV light, proliferating said cells and selecting multiplying cells as cells of a continuous cell line. | 2009-08-27 |
20090215124 | Nucleic acid isolation methods and materials and devices thereof - The present invention relates to methods for purifying nucleic acid from a sample using mild conditions that do not affect the chemical integrity of the nucleic acid. The method comprises contacting the sample with an matrix entrapped chitosan solid phase which is able to bind the nucleic acids at a first pH, and then extracting the nucleic acid from the solid phase by using an elution solvent at a second pH. | 2009-08-27 |
20090215125 | DEVICES AND PROCESSES FOR NUCLEIC ACID EXTRACTION - Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface effective for binding a heterogeneous population of nucleic acids. The first port, second port, and binding chamber define a continuous fluid pathway that is essentially free of nucleic acid-specific binding sites. | 2009-08-27 |
20090215126 | NUCLEIC ACID-FREE THERMOSTABLE ENZYMES AND METHODS OF PRODUCTION THEREOF - The present invention provides thermostable enzymes, such as DNA polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in amplifying or sequencing nucleic acid molecules, including through use of the polymerase chain reaction (PCR). | 2009-08-27 |
20090215127 | ph Adjustment Free System For Producing Fermentable Sugars and Alcohol - The present invention relates to a process for producing downstream products, such as fermentable sugars (e.g., glucose) and alcohols (e.g., ethanol) from starch-containing material (e.g., grain) without a pH adjustment before or after the starch liquefaction step. | 2009-08-27 |
20090215128 | Methods for degrading lignocellulosic materials - The present invention relates to methods for degrading a lignocellulosic material, comprising: treating the lignocellulosic material with an effective amount of one or more cellulolytic enzymes in the presence of at least one surfactant selected from the group consisting of a secondary alcohol ethoxylate, fatty alcohol ethoxylate, nonylphenol ethoxylate, tridecyl ethoxylate, and polyoxyethylene ether, wherein the presence of the surfactant increases the degradation of lignocellulosic material compared to the absence of the surfactant. The present invention also relates to methods for producing an organic substance, comprising: (a) saccharifying a lignocellulosic material with an effective amount of one or more cellulolytic enzymes in the presence of at least one surfactant selected from the group consisting of a secondary alcohol ethoxylate, fatty alcohol ethoxylate, nonylphenol ethoxylate, tridecyl ethoxylate, and polyoxyethylene ether, wherein the presence of the surfactant increases the degradation of lignocellulosic material compared to the absence of the surfactant; (b) fermenting the saccharified lignocellulosic material of step (a) with one or more fermenting microorganisms; and (c) recovering the organic substance from the fermentation. | 2009-08-27 |
20090215129 | Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family Having Expression of the leuO Gene Attenuated - The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus | 2009-08-27 |
20090215130 | L-AMINO ACID PRODUCING BACTERIUM AND METHOD OF PRODUCING L-AMINO ACID - An L-amino acid is produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the activity of an iron transporter is increased by enhancing expression of one or more genes of the following genes: tonB gene, fepA gene, and fecA. | 2009-08-27 |
20090215131 | L-GLUTAMIC ACID PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-GLUTAMIC ACID - The present invention describes an L-glutamic acid-producing bacterium which belongs to the genus | 2009-08-27 |
20090215132 | Novel amide hydrolase gene - The present invention relates to an amide hydrolase which is with excellent thermostability and stereoselectively hydrolyzes an α-amino acid amide; a gene encoding the enzyme protein; a novel recombinant vector containing the gene; a transformant containing the recombinant vector; and a process for producing an L-α-amino acid using the transformant. | 2009-08-27 |
20090215133 | PRODUCTION OF L-LYSINE AND L-LYSINE-CONTAINING FEED ADDITIVES - The invention relates to a process for producing L-lysine or L-lysine-containing feed additives by fermentation, which comprises
| 2009-08-27 |
20090215134 | Genetically modified microorganism and process for production of macrolide compound using the microorganism - A genetically modified microorganism capable of directly producing a 16-hydroxylated macrolide compound; and a process for producing a 16-hydroxylated macrolide compound using the microorganism. Specifically, a genetically modified microorganisms having DNA encoding a polypeptide involved in the biosynthesis of a macrolide compound pladienolide and DNA encoding a polypeptide having a pladienolide 16-hydroxylase activity; and a process for producing a 16-hydroxylated macrolide compound comprising the steps of culturing the genetically modified microorganism in a culture medium and collecting a 16-hydroxylated macrolide compound from the culture medium. | 2009-08-27 |
20090215135 | Novel Gene STS 22 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 2009-08-27 |
20090215136 | PSEUDOMONAS SP, HN-72 AND PURIFICATION METHOD OF 2,6-NAPHTHALENE DICARBOXYLIC ACID USING THE SAME - Provided are a novel microorganism and a method for purifying 2,6-naphthalene dicarboxylic acid with high purity using the microorganism. The microorganism is | 2009-08-27 |
20090215137 | METHODS FOR THE ECONOMICAL PRODUCTION OF BIOFUEL PRECURSOR THAT IS ALSO A BIOFUEL FROM BIOMASS - Methods for producing a biofuel precursor are provided. Also provided are biocatalysts that convert a feedstock to a biofuel precursor. | 2009-08-27 |
20090215138 | MODIFIED YEAST CONSUMING L-ARABINOSE - The present invention relates to a method for producing a L-arabinose utilizing yeast strain for the production of ethanol, whereby a yeast strain is modified by introducing and expressing araA gene (L-arabinose isomerase), araB gene (L-ribulokinase D | 2009-08-27 |
20090215139 | ETHANOL RECOVERY PROCESS AND APPARATUS FOR BIOLOGICAL CONVERSION OF SYNGAS COMPONENTS TO LIQUID PRODUCTS - Ethanol and other liquid products produced by the contacting CO and/or a mixture of CO | 2009-08-27 |
20090215140 | Novel Microalga and Process for Producing Hydrocarbon - An object of the present invention is to provide a novel microalga that produces hydrocarbons available as an alternative fuel to a diesel fuel (light oil). | 2009-08-27 |
20090215141 | BIOFUEL GENERATING SYSTEM - A biofuel generating method and biofuel generating device comprising operationally linking an anaerobic digester with a hydroponic biomass energy crop production system in a symbiotic relationship. The hydroponic system continually provides high energy containing biomass crops as feed stock to the anaerobic digestor and the anaerobic digestor provides nitrogenous digestate into the nutrient hydroponic system as a nutrient, to facilitate growth of additional biomass feed stock. The anaerobic digestor further provides the requisite carbon dioxide for the hydroponic crop feed stock to stimulate germination of crop seeds and the growth of crop seedlings. Heat generated from the anaerobic digestion process is also optionally channeled to the hydroponic system to further accelerate and promote hydroponic feed stock crop growth. The anaerobic digester produces combustible fuel including methane gas during the digestion process. | 2009-08-27 |
20090215142 | HORIZONTAL ARRAY BIOREACTOR FOR CONVERSION OF SYNGAS COMPONENTS TO LIQUID PRODUCTS - A membrane supported bioreactor arrangement and method for anerobic conversion of gas into liquid products including membrane modules having hollow fibers, each of the hollow fibers formed from an asymmetric membrane wall having a porous outer layer defining biopores for retaining a porous biolayer about the outer surface of the membrane wall and a less permeable hydration layer around the hollow fiber lumen; a membrane vessel for retaining the membrane modules in a process gas for formation of the biolayer on the outer surface of the hollow fiber wall by interaction of microorganisms with a process gas and for the production of a liquid product, wherein the membrane vessel retains the membrane modules in a common horizontal plane; provides a seal between contents of the membrane tank and ambient atmosphere; and includes a liquid supply conduit for communicating the process liquid with the hollow fiber lumens of the hollow fibers. | 2009-08-27 |
20090215143 | Controlled alteration of pores using fluid flow and fabrication of articles thereby - The invention relates to microscopic structures and methods of making and using the structures. A method of forming a microscopic structure of a material includes obtaining a solution ( | 2009-08-27 |
20090215144 | IMMOBILISATION OF BACTERIA TO A GEOLOGICAL MATERIAL - The invention relates to a method for immobilising bacteria in a material permeable to the bacteria, in particular a geological body, comprising forming a first zone comprising the bacteria in the material and allowing the first zone to move through at least part of the material; forming a second zone comprising an effective amount of a flocculating agent to the material and allowing the second zone to move through at least part of the material, wherein the zones are allowed to move such that the zones become at least partially overlapping and at least part of the bacteria flocculate, thereby becoming immobilised. | 2009-08-27 |
20090215145 | METHOD FOR CONTROLLING NAD(P)/NAD(P)H RATIO BY OXIDOREDUCTASE - Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P) | 2009-08-27 |
20090215146 | Method for Producing Virus-Type Particles Containing an Active Substance - The invention relates to a method for producing virus-type particles containing an active substance. Proteins, which comprise a first amino acid sequence which is derived from a first virus protein, and fusion proteins are assembled in order to form the virus-type particles. The proteins and the fusion proteins are coexpressed in yeast cells. | 2009-08-27 |
20090215147 | Use of Mutant Herpes Simplex Virus-2 for Cancer Therapy - The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic activity, and comprises a modified/mutated ICP10 polynucleotide encoding a polypeptide having ribonucleotide reductase activity and lacking protein kinase activity. | 2009-08-27 |
20090215148 | Conjugates of biological substances - Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and the 3-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivate compounds having one or more benzo nitrogens. | 2009-08-27 |
20090215149 | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics - The invention provides isolated polypeptide and nucleic acid sequences derived from | 2009-08-27 |
20090215150 | Sample container and filtration apparatus and method of filtration using the same - A sample container and filtration apparatus is described comprising a sealable sample container and a surface that is configured to interface with a vacuum base. When the surface interfaces with the vacuum base, a portion of the sample container is broached, providing a pathway for the vacuum source to pull the sample therethrough. In exemplary embodiments, the broachable portion of the sample container comprises an actuating valve. The method for using the sample container and filtration apparatus significantly reduces the possibility of contamination of the sample and during the sample testing procedure relative to the conventional devices and procedures, provides more consistent and reliable test results, and significantly reduces the number of preparation and testing steps for the testing procedure. | 2009-08-27 |
20090215151 | Two-Step Immunization Procedure Against Chlamydia Infection - A host is immunized against infection by a strain of | 2009-08-27 |
20090215152 | Acetoin high-yield bacillus pumilus strain - A high-yield bacterial strain for producing acetoin named | 2009-08-27 |
20090215153 | Stacked Array Bioreactor for Conversion of Syngas Components to Liquid Products - A membrane supported bioreactor arrangement and method for anaerobic conversion of gas into liquid products including membrane modules having hollow fibers packed across a cross sectional area of the membrane module, each of the hollow fibers formed from an asymmetric membrane wall having a porous outer layer defining biopores for retaining a porous biolayer about the outer surface of the membrane wall and a less permeable hydration layer around the hollow fiber lumen; a membrane vessel for surrounding the outside of the hollow fibers with a process gas from a gas supply conduit; and a liquid supply conduit operably connected to the hollow fibers for supplying a process liquid to the hollow fiber lumens. The gas supply conduit enables the formation of a biolayer on the outer surface of the hollow fiber wall by interaction of microorganisms with the process gas and the production of a liquid product. | 2009-08-27 |
20090215154 | Method of preparing micro-and nanometric particles with labile Products - The invention relates to a method of obtaining micro- and nanometric polymeric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow, uniform size distribution. The invention comprises the use of an easy particle-forming method consisting in using hydrodynamic forces to focus a composite microjet formed by two concentric fluids and can be used in the encapsulation of fragile compounds of biological interest, from peptides and proteins to cells and micro-organisms. | 2009-08-27 |
20090215155 | Algae Producing Trough System - A trough lining assembly is placed in a series of troughs at a biomass processing facility. The trough lining assembly includes a waterproof liner that lies against the sides of a trough, an aerator, and a retention mechanism that retains the aerator at the bottom of the trough. The aerator provides continuous aeration of biomass present in the trough by releasing aerating gas into the biomass along the length of the trough. The continuous aeration also churns the biomass, exposing more of it to the aerating gas and to sunlight. The trough lining assembly improves the efficiency of algae production by stimulating photosynthesis and consumption of carbon dioxide. The trough lining assembly has low production, transportation, installation, and maintenance costs. | 2009-08-27 |
20090215156 | Method for Fabricating Nanogap and Nanogap Sensor - The present invention relates to a method of fabricating a nanogap and a nanogap sensor, and to a nanogap and a nanogap sensor fabricated using the method. The present invention relates to a method of fabricating a nanogap and a nanogap sensor, which can be realized by an anisotropic etching using a semiconductor manufacturing process. According to the method of present invention, the nanogap and nanogap sensor can be simply and cheaply produced in large quantities. | 2009-08-27 |
20090215157 | METHODS FOR PATHOGEN DETECTION - The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens. | 2009-08-27 |
20090215158 | Micro Flow Channel Chip - A micro flow channel chip of the present invention has multiple grooves formed on a substrate to be connected with each other in parallel or in series and capillaries, chemically-modified in a manner different from each other, laid in the multiple grooves, wherein detected data can be obtained by supplying a fluid to the capillaries laid in the multiple grooves. The micro flow channel chip enables multiple items of chemical and biochemical functions to be measured simultaneously. The micro flow channel chip enables multiple items of chemical and biochemical functions to be measured simultaneously using micro flow channels formed on the substrate. | 2009-08-27 |
20090215159 | DEVICE FOR HANDLING AND ANALYSIS OF A BIOLOGICAL SAMPLE - An apparatus for detection of an analyte of interest in a solid, semi-solid, or liquid biological sample, using a lateral flow assay test strip, is described. The apparatus minimizes sample handling and manipulation upon introduction of the sample into a sample-receiving chamber and transfer of the sample to a test chamber containing the assay strip. | 2009-08-27 |
20090215160 | ENDOSCOPE WASHING AND DISINFECTING EVALUATION APPARATUS - A connection base portion of a stripping solution unit storing a stripping solution is connected to an insertion opening of a channel in an insertion portion of an endoscope. A distal end portion of the insertion portion formed with a distal end opening of the channel is attached, with a sealing film, to an opening in a top cover of a bacteria collection container with a filter inside to be sealed from outside. By suction operation of a syringe at a bottom of the bacteria collection container, the stripping solution is sucked into the insertion opening, flows out from the distal end opening through the channel, and is filtered through the filter. A medium is supplied to the filter for cultivation. A result of the cultivation is observed, and an evaluation result as to cleanliness is obtained from presence or absence of bacteria. | 2009-08-27 |
20090215161 | MICROORGANISM TESTING DEVICE AND CHIP FOR TESTING MICROORGANISMS - There is disclosed a microorganism testing device in which various types of microorganisms can be easily concentrated. The microorganism testing device includes a detection chip, a carrier device, a controller, and a magnet. The detection chip includes a specimen container for holding a specimen containing microorganisms, a trapping particle liquid container for holding trapping particle liquid containing magnetic particles, a microorganism trapping section for trapping the microorganisms, and a liquid flow path. In a state where a magnetic force of the magnet acts on the microorganism trapping section, the controller controls the carrier device to flow the trapping particle liquid into the microorganism trapping section to form a filtration filter by trapping plural magnetic particles in the microorganism trapping section, and in this state, to flow the microorganisms into the microorganism trapping section so that the microorganisms within the specimen are deposited on one side of the filtration filter. | 2009-08-27 |
20090215162 | Nucleic acid amplification device - This invention provides a nucleic acid amplification device whereby the abundance of a target molecule can be maintained before and after a step of separately amplifying a sample such that highly accurate analysis results that can be applied to gene expression analysis can be obtained. Also, a nucleic acid amplification device having a structure in which a plurality of minute reaction cells each comprising a set of a bead-retaining space capable of retaining a single analysis bead and a reagent reaction space retaining no bead but having a volume that is large enough to cause a reagent reaction therein are positioned so as to form a planar face is provided. | 2009-08-27 |
20090215163 | SYNGAS CONVERSION SYSTEM USING ASYMMETRIC MEMBRANE AND ANAEROBIC MICROORGANISM - A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO | 2009-08-27 |
20090215164 | Recombinant gene of adenovirus vector and p53 gene for treating proliferative diseases - The invention relates to the application of a recombinant of adenovirus vector and human tumor suppressor p53 gene expression cassette for producing the medicine for treating proliferative disease. In particular the invention relates to the application of a recombinant of adenovirus vector and human tumor suppressor p53 gene expression cassette for producing the medicine for treating scar. | 2009-08-27 |
20090215165 | High-level expression of recombinant antibody in a mammalian host cell - A mammalian host cell with a high-level expression of recombinant antibody containing a double-gene vector with gene optimized nucleotide sequences encoding the light and the heavy antibody chains. The double-gene vector itself. A process for enhancing the production of recombinant antibody in a mammalian host cell. | 2009-08-27 |
20090215166 | Cationic Polymer for Transporting Nucleic Acids in Cells - The invention relates to a cationic polymer containing cationic oligomers cross-linkable by fissile linker sequences, wherein said cationic polymers form, together with nucleic acids, polyplexes and can be used for cell transfection and the invention is characterised in that the cationic polymer contains intracellular reductive or enzymatic fissile linker sequences. | 2009-08-27 |
20090215167 | Cationic graft-copolymer for non-viral gene delivery vector - A cationic graft-copolymer for a non-viral gene delivery vector comprising a unit derived from a cationic derivative of a water-soluble linear polymers having a hydroxyl groups, namely, a cationic polysaccharide of the following formula (1) and the cationic derivative of polyvinylalcohol of the following formula (2) or the cationic derivative of the partial hydrolyzed polyvinylalcohol of the following formula (3) and a unit derived from a polymerizable olefin compound of the following formula (4) | 2009-08-27 |
20090215168 | Transcriptional control in alicyclobacillus acidocaldarius and associated genes, proteins, and methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 2009-08-27 |
20090215169 | Method for regulating protein function in cells using synthetic small molecules - Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein. | 2009-08-27 |
20090215170 | Plexin family-like polypeptide, DNA encoding the same and uses thereof - The present invention is directed to a novel plexin family like DNA, a gene containing the DNA, novel polypeptide encoded by the DNA, a recombinant protein containing the polypeptide or heterologous polypeptide sequences, antibodies which bind to the polypeptides, methods for producing the polypeptides of the present invention. Conditions that can be diagnosed, screened, prevented, or treated by the compositions herein include prophylactic, angiogenesis and conservation of functions in various organs, angiogenesis at the time of tumor and regeneration of various organs, proliferation, differentiation and preservation of function of the cells in various organs, aging, and dysfunction of the present invention. | 2009-08-27 |
20090215171 | PELCAM-1-related molecules compositions kit of parts and associated methods of use - An isolated polynucleotide coding for platelet endothelial cell adhesion molecule-1 (PECAM-1), and obtainable by amplifying cDNA from total human white blood cells by PCR; peptides encoding PECAM-1 5 | 2009-08-27 |
20090215172 | Methods and Compositions Related to Cyclic Peptide Synthesis - Disclosed are compositions and methods for cyclization of polymers such as peptides. | 2009-08-27 |
20090215173 | PKD Ligands and Polynucleotides Encoding PKD Ligands - The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate protein kinase D (PKD) activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to cellular localization signals, epitope tags and/or reporters. The invention also includes polynucleotides encoding the ligands and polyligands. | 2009-08-27 |
20090215174 | Methods of inhibiting umami taste receptors - Methods of inhibiting umami taste receptors are provided. These methods comprise contacting T1R1/T1R3 umami taste receptors with a sweet-taste inhibitor that also inhibits both the T1R1/T1R3 umami taste receptor and the T1R2/T1R3 sweet taste receptor. | 2009-08-27 |
20090215175 | MODULATION OF THE POLIOVIRUS RECEPTOR FUNCTION - The present invention relates to the identification, the isolation and the use of molecules interfering with the function (s) mediated by the poliovirus receptor (PVR) on cells. The molecules can be used for the treatment of cells having a metastatic potential, metastasis and cancer. Further methods are provided that are useful for identifying and isolating molecules, which have the capacity to modulate PVR mediated adhesion or invasion potential of cells. | 2009-08-27 |
20090215176 | Differential Pressure Pump System - The present disclosure is directed to a fluid pumping mechanism that uses differential pressure to drive flow through one or more culture chambers. Fluid contained within a first chamber can be caused to flow through one or more culture chambers and thence to a second chamber upon establishment of a pressure differential between the two chambers. The differential pressure system can induce either steady state or pulsatile flow through a culture chamber. In one embodiment, a culture chamber can be held at a high or low pressure hydrostatic state through utilization of the disclosed systems. | 2009-08-27 |
20090215177 | METHODS, SURFACE MODIFIED PLATES AND COMPOSITIONS FOR CELL ATTACHMENT, CULTIVATION AND DETACHMENT - The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and a contact angle of at least about 13.9 degrees, lacking a feeder cell layer and lacking an adlayer. In one embodiment of the present invention, the cells are treated with a compound capable of inhibiting Rho kinase activity. In another embodiment, the cells are treated with a compound capable of inhibiting Rho activity. | 2009-08-27 |
20090215178 | Methods to enhance the stability and homogeneity of transgene expression in clonal cell lines - Strategies for increasing the productivity of recombinant protein expression in isogenic cell-lines. Development of a novel selection system for the improved stability and homogeneity of transgene expression in isogenic cells without the dependence on continuous selective drugs. | 2009-08-27 |
20090215179 | Transgenically preventing establishment and spread of transgenic algae in natural ecosystems - Genetic mechanisms for mitigating the effects of introgression of a genetically engineered genetic trait of cultivated algae or cyanobacteria to its wild type or to an undesirable, interbreeding related species. as well as preventing the establishment of the transgenic algae or cyanobacteria in natural ecosystems. | 2009-08-27 |
20090215180 | ELECTRONIC CHEMICAL TRACE DETECTOR - A hotplate chemical trace detector comprising a heatable conducting plate with a heater element having a predetermined temperature-power characteristic. A balancing circuit comprises an adjustable resistor for tuning the heater element to a predefined resistor value. A processor is provided for adjusting the adjustable resistor so as to provide a stabilized temperature in said heatable conducting plate and a detection circuit is provided for detecting a change of resistance in the heatable conducting plate in accordance with the presence of a chemical trace reacting in the presence of the conducting plate. According to the invention a test circuit is provided for measuring a dissipated power in the heater element and for calculating a real temperature from the dissipated power in the heater element based on the predetermined temperature-power characteristic. | 2009-08-27 |
20090215181 | Multi-Analyte Reference Solutions - The present invention provides a reference solution for use in instruments that determine hematocrit levels in biological samples by measuring the resistance and/or conductivity of the biological samples. A reference solution according to the invention achieves conductivities representative of known hematocrit levels in blood, while maintaining tolerable levels of interference with the measurement of other analytes in the reference solution. | 2009-08-27 |
20090215182 | METHOD, COMPOSITION AND DEVICE FOR SAMPLING NATRIURETIC PEPTIDES IN A BIOLOGICAL FLUID - Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides. | 2009-08-27 |
20090215183 | Specimen analyzer, abnormality control method of the same and computer program product - Specimen analyzer includes a first holding section for holding a container; a first mechanism section for executing a first operation for the container on the first holding section; a second holding section for holding the container; a first transfer mechanism section for transferring the container from the first holding section to the second one; a second mechanism section for executing a second operation for the container on the second one; an error detector for detecting error in the first mechanism section; and an error controller for controlling the operation of the first holding section, the first and second operation so that the first operation and the transfer operation of the first holding section would be stopped while the second operation would be continued in case of the error in the first mechanism section. An abnormality control method of the analyzer and computer program product are also disclosed. | 2009-08-27 |
20090215184 | Sample analyzer and sample analyzing method - A sample analyzer includes an order receiver for receiving an analyzing order of a sample having analyzing item information; an analyzing section for analyzing a sample according to the analyzing order received by the order receiver; a calculator for counting a first number of analyses by the analyzing section in a first counting period, and a second number of analyses by the analyzing section in a second counting period different from the first counting period; a selection receiver for receiving a selection of either one of the first counting period and the second counting period; an output section; and an output controller for outputting a number of analyses in the counting period received by the selection receiver to the output section based on the counted result by the calculator is disclosed. A sample analyzing method is also disclosed. | 2009-08-27 |
20090215185 | Non-signal Imidazole Reagents for Mass Spectrometry Analysis of Phosphomonoesters - Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-compounds simultaneously. | 2009-08-27 |
20090215186 | Method for Procyanidin Analysis - The present invention relates to a novel method for quantifying procyanidin and flavan-3-ols contained in natural products, foods and drinks, pharmaceuticals and/or cosmetics. The present invention provides a method for quantifying procyanidin (a generic name for a mixture of catechin n-mer; n≧1) contained in test samples such as natural products, foods and drinks, pharmaceuticals and/or cosmetics, which comprises a) pretreating a test sample using a column to remove contaminants which affect the analysis of procyanidin and flavan-3-ol; and b) effecting high performance liquid chromatography (HPLC) to separate and quantify procyanidin and flavan-3-ols in the solution treated to remove contaminants during the above pretreatment step a). | 2009-08-27 |
20090215187 | Methods and Compositions for the Detection and Analysis of Nucleic Acids by Signal Amplification - The present invention relates to a novel integrated PCR-free signal amplification polynucleotide detection system which combines a specific receptor, an optical transducer, and an amplification mechanism. This novel detection system is based on different electrostatic interactions and confirmations between a cationic polythiophene (i.e., polymer 1) and single-stranded or double-stranded polynucleotides (such as ss-DNA or ds-DNA), and the efficient energy transfer between the triplex (complexation between the cationic polythiophene and ds-DNA) and neighboring fluorophores attached to ss-DNA or ds-DNA probes. It is to be understood that in the case of ss-DNA, triplex formation occurs via the hybridization of complementary ss-DNA strands, combined with complexation and with the cationic polythiophene. The present detection system allows for the detection of single nucleotide polymorphisms (SNPs) from samples in only a few minutes, without the need for nucleic acid amplification. | 2009-08-27 |
20090215188 | Method for labeling or treating a biological sample containing biological molecules of interest, in particular nucleic acids - The present invention relates to a method for labeling biological molecules of interest contained in a biological sample, consisting in:
| 2009-08-27 |
20090215189 | Sensor of species including toxins and chemical warfare agents - The present invention generally relates to emissive materials, devices, and related methods. In some cases, the present invention provides sensors and methods for the determination of analytes, wherein the analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. The analyte and the emissive material may interact via a chemical reaction, such as an oxidative addition reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be useful in the detection of a wide variety of analytes, such as toxins, chemical warfare agents, and explosives. The present invention also provides emissive compounds, and related methods, including metal complexes that are capable of interacting with an analyte to produce a change in the emission of the compound. Some advantages of the present invention include the determination of analytes with high specificity and sensitivity and the ability to fabricate simplified and highly portable devices. | 2009-08-27 |
20090215190 | APPARATUS AND METHOD FOR EXOTHERMIC AND ENDOTHERMIC REACTIONS - The present invention generally relates to an apparatus and method for running a plurality of essentially simultaneous exothermic reactions, endothermic reactions, or a combination thereof in sealed reactors and obtaining physico-chemical data, preferably temperature data, and, optionally, time data, for the reactions, wherein reaction mixtures in the sealed reactors are adiabatically thermally insulated from one another so that temperature in one sealed reactor does not materially affect temperature in any other, including an adjacent, sealed reactor. | 2009-08-27 |
20090215191 | Optical Sensor For Detecting Chemical Reaction Activity - The invention provides an optical sensor for detecting chemical reaction activity, including, e.g., enzyme activity and catalytic or reactive molecule activity. An optical sensor of the invention includes a porous photonic film that produces a predetermined spectral reflectance response. In preferred embodiments, the film has a chemical coating (such as a hydrophobic layer) within its pores with an affinity for the reaction product(s) of the catalytic or otherwise reactive analyte A coating can also act as a protective layer in preferred embodiment. A thin substrate susceptible to reaction by at least one analyte of interest is on the surface of the thin film to block pores of the thin film. A method of detecting chemical reaction activity of the invention exposes the optical sensor to an analyte of interest, such as an enzyme or otherwise catalytic or reactive molecule. The optical sensor is subjected to light and the reflectivity spectrum of the optical sensor is monitored for a change indicative of reaction activity. Monitoring can include observation for a visible change or data acquisition via instruments such as a spectrometer for monitoring for a change in interferometric reflectance spectra. | 2009-08-27 |
20090215192 | Solid-phase affinity-based method for preparing and manipulating an analyte-containing solution - A method for preparing an analyte-containing solution, which is compatible with surface-tension-directed liquid droplet manipulation and solid-phase affinity-based assays, is disclosed. The method comprises providing an affinity capture surface comprising a substrate surface having a plurality of first and second surface modifiers associated therewith, wherein the first and second surface modifiers render the affinity capture surface wettable and resistant to non-specific protein adsorption, and wherein the second surface modifiers are capable of selectively retaining an analyte, contacting the affinity capture surface with the analyte to form analyte/surface modifier complexes between the analyte and the second surface modifiers, and cleaving the first and second surface modifiers to release terminal portions of the first and second surface modifiers and the analyte into a solution in contact with the affinity capture surface, thereby yielding the analyte-containing solution and generating a hydrophobic surface. Novel affinity capture surfaces and methods for preparing the same are also disclosed. | 2009-08-27 |
20090215193 | Application of a reagent to a matrix material - A reagent or particles having reagent supported thereon are applied to a matrix material by a contact printing process for example in which the matrix material is brought into contact with a rotating contact roll having the reagent or particles having reagent supported thereon disposed thereon so as to transfer the reagent or particles having reagent supported thereon to the matrix material. Such a contact printing processes allow high speed and high volume production of an assay device. | 2009-08-27 |
20090215194 | ASSEMBLY OF A MICROFLUIDIC DEVICE FOR ANALYSIS OF BIOLOGICAL MATERIAL - In a microfluidic assembly, a microfluidic device is provided with a body in which at least a first inlet for loading a fluid for analysis, and a buried area in fluid communication with the first inlet are defined. An analysis chamber is in fluid communication with the buried area and an interface cover is coupled in a fluid-tight manner above the microfluidic device. The interface cover is provided with a sealing portion in correspondence to the analysis chamber, operable to assume a first configuration, in which it leaves the analysis chamber open, and a second configuration, in which it closes the analysis chamber in a fluid-tight manner. | 2009-08-27 |
20090215195 | Set1 proteins and uses thereof - The invention relates to methods of use of SET1 proteins or functional equivalents thereof. More particularly the invention relates to the use of SET1 proteins or functional equivalents thereof in procedure, for identification and/or isolation of IgA and the scrum complement factor C5. | 2009-08-27 |
20090215196 | Sequential Method - A method for determination of an analyte in an original liquid sample by performing an inhibition affinity assay in a microchannel structure of a microfluidic device. The main characteristic feature is the steps of: (i) providing the microfluidic device in a form where the microchannel structure comprises a reaction microcavity which a) an inlet end, and b) contains a solid phase with binding sites (BS) for an analyte or an analyte-related entity, (ii) providing a liquid sample (1) containing the analyte or the analyte-related entity within the microchannel structure at the inlet end of the reaction microcavity, and flowing sample (1) through the reaction microcavity under conditions such that the analyte or the analyte-related entity is captured by BS leaving a portion of BS unoccupied (free BS), (iii) providing a liquid sample (2) which contains an analytically detectable analogue of the analyte or of the analyte-related entity, and flowing sample (2) through said reaction microcavity to capture the analogue by free BS, and (iv) measuring the amount of analyte analogue captured in step (iii) and relating this amount to the amount of analyte in an original sample. | 2009-08-27 |
20090215197 | TARGET SUBSTANCE CAPTURING MOLECULE - A capturing molecule having not less than two domains specifically binding to different sites of a target substance, wherein the not less than two domains comprise (1) a first domain having a hypervariable loop structure at a binding site to the target substance, and (2) a second domain having no hypervariable loop structure at a binding site to the target substance. | 2009-08-27 |
20090215198 | Immunological Latex Turbidimetry Method and Reagent Therefor - An immunological latex turbidimetry method for analyzing an antigen or antibody in a sample, comprising steps of:
| 2009-08-27 |