34th week of 2018 patent applcation highlights part 23 |
Patent application number | Title | Published |
20180237343 | METHOD FOR PRODUCING ORIENTED SINTERED BODY - A method for producing an oriented sintered body according to the present invention includes the steps of: (a) preparing a multilayer body, the multilayer body including a layer including a fine raw-material powder and a layer including a plate-like raw-material powder which are alternately stacked each other, particles of the plate-like raw-material powder being arranged such that surfaces of the particles of the plate-like raw-material powder extend along a surface of the layer including a fine raw-material powder; and (b) sintering the multilayer body. | 2018-08-23 |
20180237344 | UNSHAPED PRODUCT FOR REPAIRING GLASS MELTING FURNACES - An unshaped product including, as weight percentages, A) particles (a) of at least one refractory material other than a glass and a glass-ceramic, and the main constituent(s) of which are alumina and/or zirconia and/or silica and/or chromium oxide: B) 2% to 15% of particles (b) of a hot binder chosen from glass-ceramic particles, particles made of a glass, and the mixtures of these particles, a glass being a noncrystalline material exhibiting a glass transition temperature of less than 1100° C., the hot binder not being in the solid state at 1500° C., C) less than 2% of particles (c) of hydraulic cement, D) less than 7% of other constituents, the combined particles (a) and (b) being distributed, as weight percentages in the following way: fraction <0.5 μm: ≥1%, fraction <2 μm: ≥4%, fraction <10 μm: ≥13%, fraction <40 μm: 25%-52%. | 2018-08-23 |
20180237345 | Shaded Zirconia Ceramic Material and Machinable Sintered Ceramic Bodies Made Therefrom - Shaded, zirconia ceramic materials are disclosed that are suitable for use in dental applications. Ceramic bodies are made from a zirconia-containing ceramic material and a coloring composition comprising a terbium (Tb)-containing component and a chromium (Cr)-containing component as a coloring agent. The pre-shaded ceramic body is machinable into a dental restoration either as a bisque body or sintered body. A pre-shaded machinable sintered ceramic body may obviate the need for further processing steps, such as shading or sintering, and may be suitable for use in chair-side machining applications, such as in a dentist's office, significantly reducing the time to create a custom finished product. | 2018-08-23 |
20180237346 | METHOD OF PRODUCING A COMPONENT OF A COMPOSITE OF DIAMOND AND A BINDER - A method of producing a component of a composite of diamond and a binder, wherein a Hot Isostatic gas Pressure process (HIP) is used, includes the step of enclosing a de-bound green body having compacted diamond particles in an infiltrant. The method includes the further steps of enclosing the de-bound green body and the infiltrant in a Zr-capsule that has Zirconium as a main constituent and sealing the Zr-capsule, and applying a predetermined pressure-temperature cycle on the unit formed by the de-bound green body, infiltrant and capsule in which the infiltrant infiltrates the de-bound green body and the de-bound green body is further densified in the sense that the volume thereof is decreased. | 2018-08-23 |
20180237347 | SILICON NITRIDE SINTERED BODY WITH HIGH THERMAL CONDUCTIVITY AND METHOD FOR MANUFACTURING SAME - Embodiments relate to a method for manufacturing a silicon nitride sintered body with high thermal conductivity, which includes the steps of: a) obtaining a slurry by mixing a silicon nitride powder and a non-oxide based sintering aid; b) obtaining a mixed powder by drying the slurry; c) forming a compact by pressurizing the mixed powder; and d) sintering the compact. | 2018-08-23 |
20180237348 | CERAMIC BONDED BODY - A ceramic bonded body of the disclosure includes a first silicon carbide ceramics, a second silicon carbide ceramics, and a bonding layer positioned between the first silicon carbide ceramics and the second silicon carbide ceramics. The bonding layer contains 25 mass % or more metallic silicon, and 25 mass % or more silicon carbide assuming all components constituting the bonding layer as 100 mass %, and a total of the metallic silicon and the silicon carbide is 75 mass % or more, and the bonding layer further contains at least one of nickel silicide and chromium silicide. | 2018-08-23 |
20180237349 | METHOD OF PRODUCTION OF EDGE PROTECTION STRIPS OF CERAMIC MATERIAL - A method of production of edge protection strips ( | 2018-08-23 |
20180237350 | ARTIFICIAL SOILS AND METHODS FOR MANUFACTURING ARTIFICIAL SOILS - An artificial soil for growing vegetation includes a mixture of biosolids from a wastewater treatment plant, at least one of synthetic gypsum and a gypsum-depleted by-product, and a calcium compound from at least one of a lime kiln dust, a fluidized bed ash, and a ball mill lime. The calcium compound is present in an amount sufficient to heat the mixture to at least about 132° F. following mixing. The mixture may include at least one of silica and alumina. The artificial soil may include hydrated lime. The mixture may include at least about 1/9 by volume of biosolids and/or from about ⅛ to about ½ by volume of the calcium compound. A method of manufacturing the artificial soil includes mixing biosolids with at least one of synthetic gypsum and a gypsum-depleted by-product and at least one of a lime kiln dust, a fluidized bed ash, and a ball mill lime. | 2018-08-23 |
20180237351 | GRANULAR FERTILIZERS COMPRISING MACRONUTRIENTS AND MICRONUTRIENTS, AND PROCESSES FOR MANUFACTURE THEREOF - Novel granular fertilizers and methods of making those fertilizers are provided. The method utilized involves recycling streams, including one that provides water having dissolved solids therein, with that water being used during the mixing and granulation process. This method results in a low-moisture, hard, substantially spherical granule, which can include any number of macronutrients and/or micronutrients. Advantageously, the granular fertilizer can be applied to the soil around plants to supply those plants with the necessary nutrients. | 2018-08-23 |
20180237352 | SOLUBLE FERTILIZER FORMULATION AND METHOD FOR USE THEREOF - A fertilizer including a growth enhancing component, in at least one example a co-polymer of fulvic acid and poly-metallic humates is present in the amount of from about 80% to about 90% by weight, based on a total weight of the fertilizer; a plurality of elements present in the amount of from about 3% to about 7% by weight, based on the total weight of the fertilizer; and one or more secondary nutrients, micronutrients, and biologically active heteromolecular trace-metal complexes present in the amount of from about 3% to about 10% by weight, based on the total weight of the fertilizer.. | 2018-08-23 |
20180237353 | MICROBIAL CONSORTIA - Disclosed herein are microbial consortia and compositions including microbes, for example, for use in agricultural or biodegradation applications. In some embodiments, soil, plants, and/or plant parts (such as seeds, seedlings, shoots, roots, leaves, fruit, stems, or branches) are contacted with a disclosed microbial consortia or composition including microbes. The microbial consortia or microbe-containing compositions may be applied to soil, plant, and/or plant parts alone or in combination with additional components (such as chitin, chitosan, glucosamine, amino acids, and/or liquid fertilizer). In additional embodiments, the disclosed microbial consortia or compositions including microbes are used in methods of degrading biological materials, such as chitin-containing biological materials. | 2018-08-23 |
20180237354 | COMPETITIVE AND EFFECTIVE BACTERIAL STRAINS - According to the present invention new isolates of bacterial strains have been shown to possess unique properties. These bacterial strains are plant growth-promoting rhizobacterium (PGPR), posses an enhanced competitive advantage at colonizing leguminous plants, and enhance the overall performance of leguminous plant growth. Further still, the present invention discloses a novel method for screening and selecting bacterial strains having the aforementioned beneficial characteristics. | 2018-08-23 |
20180237355 | MULTI-NUTRIENT GRANULAR FERTILIZER COMPOSITIONS AND METHODS OF USING THE SAME - Granular fertilizer compositions are described herein that are capable of supplying a wide array of beneficial nutrient and compounds to soil for uptake by the root systems of plants. In preferred embodiments, the compositions provide a source of phosphorus, a source of nitrogen, a source of boron, a source of copper, a source of manganese, a source of zinc, and a source of sulfur in a single application, with highly efficient uptake by plants. The compositions generally comprise a mixture of two or three types of granules, each providing a supply of one or more nutrients. It has been discovered that the components of the three types of granules interact in a synergistic manner, such that problems associated to with certain nutrients in soil are overcome, thereby providing a highly efficient multi-nutrient fertilizer. | 2018-08-23 |
20180237356 | GRANULAR FERTILIZERS COMPRISING MACRONUTRIENTS AND MICRONUTRIENTS, AND PROCESSES FOR MANUFACTURE THEREOF - Novel granular fertilizers and methods of making those fertilizers are provided. The method utilized involves recycling streams, including one that provides water having dissolved solids therein, with that water being used during the mixing and granulation process. This method results in a low-moisture, hard, substantially spherical granule, which can include any number of macronutrients and/or micronutrients. Advantageously, the granular fertilizer can be applied to the soil around plants to supply those plants with the necessary nutrients. | 2018-08-23 |
20180237357 | CROWD DISPERSING COMPOSITION - A crowd dispersing composition includes a mixture including limburger cheese, rotten eggs, sulfur compounds having a smell of rotten food, rotten fish and rotten meat. The mixture is to be sprayed into a crowd of people to disperse the crowd. | 2018-08-23 |
20180237358 | RADIOISOTOPE 18F SUBSTITUTED THIAMINE, AND SYNTHESIS METHOD AND USE THEREOF - The present invention discloses a radioisotope | 2018-08-23 |
20180237359 | HYBRID CHEM-BIO METHOD TO PRODUCE DIENE MOLECULES | 2018-08-23 |
20180237360 | SELECTIVE OLIGOMERIZATION REACTION PROCESS OF ETHYLENE - The present invention relates to a commercial reaction process for the selective oligomerization reaction of ethylene, and a method for efficiently removing reaction heat to be generated in a reaction and regulating the temperature of the reactor and, more specifically, to an oligomerization reaction process of ethylene by circulating a liquid mixture in the reactor, separating unreacted ethylene from this circulation flow by an apparatus for separating unreacted ethylene from the circulation flow, and then cooling the remaining mixture and reintroducing it to the reactor, thereby removing the reaction heat in the reactor and allowing temperature control. | 2018-08-23 |
20180237361 | Aromatic Compositions and Methods for Obtaining Them - Aromatic compositions useful in various applications, such as aromatic fluid solvents and high temperature heat transfer fluids, are provided herein. Also provided are advantageous methods for obtaining the aromatic compositions, utilizing hydroalkylation of precursor aromatic hydrocarbons such as benzene, toluene, xylene, and the like. Particularly preferred aromatic compositions include one or more of cycloalkylaromatic, dicycloalkylaromatic, biphenyl, terphenyl, and diphenyl oxide compounds. The aromatic compositions may be blended with an aromatic solvent or other aromatic fluid comprising one or more of alkylnaphthalenes, alkylbenzenes, and naphthalene, e.g., to form a useful aromatic fluid solvent, or the aromatic compositions may be utilized as high temperature heat transfer fluids (with or without additional blend components). | 2018-08-23 |
20180237362 | NOVEL POLYGODIAL ANALOGS FOR THE TREATMENT OF CANCER AND OTHER PROLIFERATIVE DISEASES - The present disclosure relates generally to derivatives of polygodial and methods of use thereof. In some aspects, the present disclosure relates to using polygodial derivatives to treat cancer or other hyperproliferative diseases. | 2018-08-23 |
20180237363 | METHOD FOR COUPLING AN AROMATIC COMPOUND TO AN ALKYNE - In one aspect, there is provided a method of coupling an aromatic compound having a fluorosulfonate substituent to an alkyne. In another aspect, there is provided a method of coupling an aromatic compound having a hydroxyl substituent to an alkyne in a one-pot reaction. | 2018-08-23 |
20180237364 | CATALYTIC CHLORINATION OF 3,3,3-TRIFLUOROPROPENE TO 2,3-DICHLORO-1,1,1-TRIFLUOROPROPANE - The present invention relates to a process for preparing 1,1,1-trifluoro-2,3-dichloropropane which comprises contacting chlorine with 3,3,3-trifluoropropene in the presence of a catalyst to form 1,1,1-trifluoro-2,3-dichloropropane, wherein the catalyst comprises at least one metal halide, where the metal is a metal from Group 13, 14 or 15 of the periodic table or a transition metal or combination thereof. | 2018-08-23 |
20180237365 | METHOD FOR PRODUCING HALOOLEFIN COMPOUND AND METHOD FOR REMOVING STABILIZER - The present invention provides a method for producing a fluorine-containing haloolefin compound, the method easily inhibiting catalyst deactivation, and the method being capable of inhibiting a decrease in conversion and selectivity in the reaction, even when the reaction is continued for a long period of time. The present invention is a method for producing a fluorine-containing haloolefin compound via a step of fluorinating a C | 2018-08-23 |
20180237366 | NOVEL PROCESS FOR METHANOL PRODUCTION FROM LOW QUALITY SYNTHESIS GAS - In a novel process for methanol production from low quality synthesis gas, in which relatively smaller adiabatic reactors can be operated more efficiently, some of the inherent disadvantages of adiabatic reactors for methanol production are avoided. This is done by controlling the outlet temperature in the pre-converter by rapid adjustment of the recycle gas, i.e. by manipulating the gas hourly space velocity in the pre-converter. | 2018-08-23 |
20180237367 | PROCESS AND SYSTEMS FOR OBTAINING 1,4-BUTANEDIOL FROM FERMENTATION BROTHS - A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol product. | 2018-08-23 |
20180237368 | CANNABIDIOL EXTRACTION AND CONVERSION PROCESS - A cannabidiol extraction and conversion process includes an extraction process including a sizing unit wherein raw | 2018-08-23 |
20180237369 | PROCESS FOR PREPARING 1,4-BIS(ETHOXYMETHYL)CYCLOHEXANE - The present invention relates to a process for preparing,4-bis(ethoxymethyl)cyclohexane, which comprises reacting1,4-bis(hydroxymethyl)cyclohexane with ethyl chloride in the presence of an inorganic base, a solvent and a phase transfer catalyst to yield a reaction mixture containing 1,4-bis(ethoxymethyl)cyclohexane, where the inorganic base is selected from alkali metal hydroxides and earth alkaline metal hydroxides and where the solvent is selected from water or a mixture of water with at least one organic solvent. | 2018-08-23 |
20180237370 | GREEN METHOD FOR COATING A SUBSTRATE WITH SILVER NANOPARTICLES - The method for coating a substrate with silver nanoparticles includes reducing a silver nitrate solution with an ethanol extract of the traditional Indian medicinal plant ( | 2018-08-23 |
20180237371 | METHOD OF CATALYTIC OXIDATION OF LIGNITE USING OXYGEN AS OXIDANT AT ATMOSPHERIC PRESSURE - Disclosed is a method of catalytic oxidation of lignite using oxygen as an oxidant at atmospheric pressure, belonging to a method of mild oxidation of lignite. The method is used to mildly oxidize the lignite using the oxygen as the oxidant under the action of a nitroxide radical catalyst and a metal salt or metal oxide cocatalyst; the process comprises the following steps: pulverizing the lignite to 200 meshes or less, drying a pulverized coal sample at a temperature of 80° C. in vacuum for 10 h, weighing 0.5 g of the treated coal sample, sequentially adding 10 ml of acetic acid, 0.5 mmol of a catalyst and 0.15 to 0.25 mmol of a cocatalyst into a round-bottom flask, connecting a tee joint to an upper orifice of a condenser pipe, replacing oxygen in vacuum for three times so that the round-bottom flask is filled with the oxygen, keeping oxygen pressure at 0.1 MPa, reacting at a temperature of 80° C. to 120° C. for 4 to 12 h; filtering after the reaction is finished; decompressing a filtrate to remove the acetic acid, adding a small amount of ethyl acetate to dissolve, then using an excess CH | 2018-08-23 |
20180237372 | METHOD FOR PRODUCING ACRYLIC ACID - A method for preparing acrylic acid, more specifically, to a method for preparing acrylic acid under a neutral condition at high yield in a short time without using a base, unlike the prior art in which a base is essentially used. The acrylic acid is produced using a supported catalyst having a specific composition when preparing acrylic acid by oxidation of allyl alcohol. Particularly, the preparation method can recover acrylic acid rather than acrylic acid salt as a final product, and thus has an advantage that the overall process cost can be reduced by eliminating essential processes in the prior art, such as ion exchange after the acidification process required for the conversion of acrylic acid salt to acrylic acid. | 2018-08-23 |
20180237373 | METHOD OF DETERMINING THE INERTNESS OF MATERIALS FOR USE IN MONOMER PRODUCTION - A method of determining the inertness of a material regarding the formation of heavy by-products during the reaction of propylene to acrolein and acrylic acid. | 2018-08-23 |
20180237374 | Substituted Aromatic Compounds and Related Method for the Treatment of Fibrosis - The present invention relates to compounds of: | 2018-08-23 |
20180237375 | METAL COMPOUNDS OF CALIXARENES, DETERGENT COMPOSITIONS CONTAINING THEM AND USE THEREOF IN LUBRICANT COMPOSITIONS - The present invention relates to a metal compound of calixarene not containing sulfur and dispersible in oil, which can be partially salified, or neutral, or basic or overbased, said calixarene having general formula (I) in which: a) R | 2018-08-23 |
20180237376 | METHOD FOR PREPARING ARYL SUBSTITUTED P-PHENYLENEDIAMINE SUBSTANCE - A method for preparing an aryl substituted p-phenylenediamine substance is provided. A structural formula of the aryl substituted p-phenylenediamine substance is shown as Formula (I′), where each of R′ and R″ is phenyl or o-methylphenyl, and R′ is same as or different from R″; and the method comprises that: a raw material A and a raw material B are reacted in the presence of a hydrogen acceptor and a catalyst to form the aryl substituted p-phenylenediamine substance, the raw material A having a structure shown as Formula (I), the raw material B being cyclohexanone and/or o-methylcyclohexanone and the hydrogen acceptor being a hydrogen acceptor capable of accepting hydrogen for conversion into the raw material B. Raw materials are low in cost and readily available; use of a large amount of water for post-treatment is avoided. The reaction condition is relatively mild, and corrosion to equipment is avoided. | 2018-08-23 |
20180237378 | Asymmetric Bisamidation of Malonic Ester Derivatives - The present invention relates to processes, process steps and intermediates useful in the asymmetric bisamidation of malonic ester derivatives wherein the new processes, process steps and intermediates are, for example, useful in the preparation of asymmetric malonic acid bisanilides such as cabozantinib. | 2018-08-23 |
20180237379 | SUBSTITUTED MALONAMIDES AND THEIR USE AS ANTIBACTERIAL DRUGS - Disclosed are a series of malonamide derivatives having a chemical structure(I), their synthesis, and evaluation of their bioactivities against bacterial cell, bacterial-infected | 2018-08-23 |
20180237380 | IMMUNOASSAY - Antibodies, immunoassay methods and kits for the detection and determination of 3,4,-dichloro-N-[2-(dimethylamino)cylohexyl]-N-methylbenzamide and 3,4,-dichloro-N-[2-(methylamino)cylohexyl]-N-methylbenzamide, as well as the precursory immunogens, are described. | 2018-08-23 |
20180237381 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY - This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels. | 2018-08-23 |
20180237382 | NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS - The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R | 2018-08-23 |
20180237383 | NATURAL PRODUCT ANALOGS INCLUDING AN ANTI-INFLAMMATORY CYANOENONE PHARMACORE AND METHODS OF USE - This invention provides novel compounds comprising the following anti-inflammatory pharmacore: | 2018-08-23 |
20180237384 | 3-PHENYLISOSERINE DERIVATIVE PRODUCTION METHOD - A method produces a 3-phenylisoserine derivative by protecting an amino group of a compound represented by General Formula (1) (wherein R | 2018-08-23 |
20180237385 | AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1 - Some novel compounds are provided in this disclosure. These novel compounds have potential SHP-1 agonist activity for being used in treating cancer. | 2018-08-23 |
20180237386 | Process For Preparation Of Vortioxetine Hydrobromide - The present invention provides a process for preparation of Vortioxetine hydrobromide (I). The present invention also relates to the novel intermediate and its use in preparation of vortioxetine hydrobromide (I). | 2018-08-23 |
20180237387 | CERAMIDE DIMER, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME - The invention relates to ceramide dimers in which the amino alcohols are linked together by amide bonds via a dicarboxylic acid. The dicarboxylic acids have at least one sulfur atom in the chain. The invention also relates to a method for producing the ceramide dimers. The ceramide dimers are used as active ingredients to stabilize the skin barrier in cosmetic and pharmaceutical preparations. | 2018-08-23 |
20180237388 | PROCESS FOR THE PREPARATION OF LACTAMS FROM GLYCOXYLIC ACID - A process for the synthesis of lactams suitable for use in antimicrobial, anti-biofilm bacteriostatic compositions. | 2018-08-23 |
20180237389 | METHOD OF PRODUCING EPSILON-CAPROLACTAM - A method of producing ε-caprolactam from 3-oxoadipic acid includes: step 1 of mixing at least one selected from the group consisting of 3-oxoadipic acid and salts thereof with a catalyst and a solvent in the presence of hydrogen to produce 3-hydroxyadipic acid; and step 2 of reacting the 3-hydroxyadipic acid which is a product of step 1, a salt or carboxylic acid derivative thereof, or a mixture of these with hydrogen and ammonia. | 2018-08-23 |
20180237390 | IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST - The present invention relates to novel processes for the preparation of apremilast of formula I, or a pharmaceutically acceptable salt thereof. | 2018-08-23 |
20180237391 | OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE - The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina. | 2018-08-23 |
20180237392 | CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE - The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation. | 2018-08-23 |
20180237393 | ORGANIC COMPOUND, ELECTROCHROMIC ELEMENT, OPTICAL FILTER, LENS UNIT, IMAGE PICKUP APPARATUS, AND WINDOW MEMBER - Provided is an organic compound, which is represented by the general formula (1): | 2018-08-23 |
20180237394 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS - The present invention provides compounds for the treatment of a bacterial infection. Additionally, the present invention provides compositions and methods for using these compounds and compositions in the treatment of a bacterial infection in a subject. | 2018-08-23 |
20180237395 | (--)-HUPERZINE A PROCESSES AND RELATED COMPOSITIONS AND METHODS OF TREATMENT - The invention provides (1) processes for making substantially-pure (−) huperzine A and substantially-pure (−) huperzine A derivatives; (2) compositions useful in making substantially-pure (−) huperzine A and substantially-pure (−) huperzine A derivatives; and (3) methods of treating or preventing neurological disorders using substantially-pure (−) huperzine A and substantially-pure (−) huperzine A derivatives. | 2018-08-23 |
20180237396 | Processes For Preparing AG-10, Its Intermediates, and Salts Thereof - Provided herein are improved processes for the preparation of a compound of Formula IX (AG-10). Also provided herein are pharmaceutically acceptable salts of Formula I and Formula Ib | 2018-08-23 |
20180237397 | PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described. Formula (I). | 2018-08-23 |
20180237398 | UREA DERIVATIVE AND USE THEREFOR - A compound has inhibitory activity on Discoidin Domain Receptor 1. A urea derivative is represented by the formula (I) or a pharmaceutically acceptable salt thereof: | 2018-08-23 |
20180237399 | COMPOUNDS HAVING AGONISTIC EFFECT AGAINST GPR84, PREPARATION METHOD FOR COMPOUNDS AND USE OF COMPOUNDS - The present invention relates to a class of compounds represented by the formula I, or pharmaceutically acceptable salts thereof, methods for their preparation, and application as small molecule tools that function as GPR84 agonists, and their use in preparing a medicament for the treatment of septicemia. | 2018-08-23 |
20180237400 | Synthesis Of Benzodiazepine Derivatives - The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: (I) | 2018-08-23 |
20180237401 | TRIAZOLE DERIVATIVES - The present invention relates to compounds of formula I | 2018-08-23 |
20180237402 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES - Novel azaquinazoline carboxamide derivatives of formula (I) | 2018-08-23 |
20180237403 | SMALL MOLECULE INHIBITORS OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER - A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: | 2018-08-23 |
20180237404 | HETEROCYCLIC COMPOUND - Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4. A compound represented by the formula (I): | 2018-08-23 |
20180237405 | TREATMENT OF MULTIPLE SCLEROSIS AND PSORIASIS USING PRODRUGS OF METHYL HYDROGEN FUMARATE - Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed. | 2018-08-23 |
20180237406 | PHENYLSULFONAMIDO-BENZOFURAN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF PROLIFERATIVE DISEASES - Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein. | 2018-08-23 |
20180237407 | PHENYLSULFONAMIDO-BENZOFURAN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF PROLIFERATIVE DISEASES - Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein. | 2018-08-23 |
20180237408 | METHOD OF PRODUCING BERAPROST - An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. | 2018-08-23 |
20180237409 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES - The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices as well as to ophthalmic devices comprising such compounds. | 2018-08-23 |
20180237410 | HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES - The present invention relates to novel compounds, particularly to hydrophilic compounds, comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices. The present application also relates to ophthalmic devices comprising such compounds. | 2018-08-23 |
20180237411 | ISOFLAVONOID COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER - Provided herein is a pharmaceutical composition comprising an isoflavonoid derivative and a cyclodextrin. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions. In specific instances, provided herein are intravenous compositions and therapies. | 2018-08-23 |
20180237412 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS - The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds. | 2018-08-23 |
20180237413 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF - The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors. | 2018-08-23 |
20180237414 | METHOD FOR THE PREPARATION OF THE METABOLITES OF (4S)- AND (4R)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NA- PHTHYRIDINE-3-CARBOXAMIDE AND THE USE THEREOF - The present invention relates to a novel method for preparing (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula 4R (I) and the metabolites of (4S)- and (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I), the formulae M1a (S), M1b (R), M2a (S), M2b (R), M3a (S) and M3b (R) and use thereof. | 2018-08-23 |
20180237415 | AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN - The present invention relates to amide derivatives having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. | 2018-08-23 |
20180237416 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS - Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole-3-carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states. | 2018-08-23 |
20180237417 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS - This application relates to substituted benzimidazoles, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted benzimidazoles and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers. | 2018-08-23 |
20180237418 | MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE - The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a cereblon, Von Hippel-Lindau ligase-binding moiety, Inhibitors of Apotosis Proteins, or mouse double-minute homolog 2 ligand, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure. | 2018-08-23 |
20180237419 | AZETIDINE COMPOUNDS AS GRP119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS - The present disclosure relates to azetidine compounds. The azetidine compounds are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The present disclosure furthermore relates to the use of azetidine compounds as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them. | 2018-08-23 |
20180237420 | BENZIMIDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS - The invention relates to benzimidazole-carboxamide 5-HT | 2018-08-23 |
20180237421 | SUBSTITUTED PYRAZOLE COMPOUNDS AS SERINE PROTEASE INHIBITORS - There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin and/or kallikrein, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which diseases or disorders are amenable to treatment or prevention by the inhibition of thrombin and/or kallikrein. | 2018-08-23 |
20180237422 | TRIAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS - The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction. | 2018-08-23 |
20180237423 | NEPRILYSIN INHIBITORS - In one aspect, the invention relates to compounds having the formula: | 2018-08-23 |
20180237424 | FGFR3 ANTAGONISTS - The invention pertains to novel FG-FR3antagonists of general formula (I), The compounds are useful for the treatments and prevention of achondroplasia and cancer. | 2018-08-23 |
20180237425 | PROCESSES FOR THE PREPARATION OF BENZODIAZEPINE DERIVATIVES - The present invention relates to processes and intermediates useful in the preparation of biologically active molecules, especially in the synthesis of Respiratory Syncytial Virus (RSV) inhibitors. The present invention also relates to processes and intermediates for the preparation of compounds of formula (I): | 2018-08-23 |
20180237426 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF - The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors. | 2018-08-23 |
20180237427 | INHIBITORS OF BETA-HYDROXYLASE FOR TREATMENT OF CANCER - The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders. | 2018-08-23 |
20180237428 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS - The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R | 2018-08-23 |
20180237429 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES - Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed. | 2018-08-23 |
20180237430 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES - Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed. | 2018-08-23 |
20180237431 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES - Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed. | 2018-08-23 |
20180237432 | BRIDGED PIPERIDINE DERIVATIVES - The present invention relates to compounds of formula | 2018-08-23 |
20180237433 | PROCESS DEVELOPMENT OF A PYRIDINE-CONTAINING NK-1 RECEPTOR ANTAGONIST - The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those routes. | 2018-08-23 |
20180237434 | MICROBIOCIDAL HETEROBICYCLIC DERIVATIVES - Compounds of the formula (I) wherein Q | 2018-08-23 |
20180237435 | GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS - Imidazo[4,5-c] ring compounds, (particularly imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine substituent at the 1-position, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed. | 2018-08-23 |
20180237436 | HYDANTOIN DERIVATIVE - The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof: | 2018-08-23 |
20180237437 | NOVEL PROCESS - A process for making certain spiroheterocyclic pyrrolidine dione derivatives. | 2018-08-23 |
20180237438 | CRYSTAL FORM OF BISULFATE OF JAK INHIBITOR AND PREPARATION METHOD THEREFOR - A crystal form I of a Janus Kinase (JAK) inhibitor (3aR,5s,6aS)-N-(3-methoxyl-1,2,4-thiadiazole-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-formamide bisulfate of formula (I) is provided. Also provided is a method of preparing the crystal form I of the JAK inhibitor of formula (I). The preparation method includes crystallizing any crystal form or amorphous compound solid of formula (I) in a single organic solvent to obtain the form I crystal. The crystal form I has excellent crystal stability and chemical stability. Additionally, the crystal solvent used to produce the crystal form I has low toxicity and a relatively low content of residual solvent, making the compound better suited for clinical treatment. | 2018-08-23 |
20180237439 | PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS - The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds. | 2018-08-23 |
20180237440 | JANUS KINASE 1 SELECTIVE INHIBITOR AND PHARMACEUTICAL USE THEREOF - Janus kinase 1 selective inhibitors and pharmaceutical use thereof are provided. | 2018-08-23 |
20180237441 | Chemical Compounds - The invention is directed to substituted pyrrolidinone and imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I: | 2018-08-23 |
20180237442 | PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS - The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases. | 2018-08-23 |
20180237443 | Chemical Compounds - The present disclosure concerns compounds of Formula (I) | 2018-08-23 |