34th week of 2012 patent applcation highlights part 38 |
Patent application number | Title | Published |
20120214185 | METHOD OF SCREENING MHC MOLECULES - The invention relates to a method for screening the binding properties of constituent peptides of MHC molecules by providing in solution MHC molecules or their constituent peptides for a set of MHC molecules including a plurality of subsets of MHC molecules, wherein the MHC molecules of each subset differ from MHC molecules of at least one other subset in at least one of the putative MHC binding peptide, an MHC alpha chain and an MHC beta chain, and loading said MHC molecules with an MHC binding peptide by (i) refolding of the MHC alpha chain and beta chain peptides in presence of said MHC binding peptide or (ii) by peptide exchange or loading with an unlabelled MHC binding peptide in the absence of any labelled MHC binding peptide, (b) taking of at least one sample from each subset, and (c) determining loading efficiency for the sample of step (b). | 2012-08-23 |
20120214186 | METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING sAPPbeta - The present invention provides methods (assays) for detecting and/or quantifying sAPPβ, a secreted β-secretase (BACE1) cleavage fragment of the β-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPPβ and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPPβ. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided. | 2012-08-23 |
20120214187 | Method for Enhancing the Sensitivity of Antibody Based Assays - There is a constant need for increased sensitivity of antibody-based assays as well as a need for high affinity antibodies. Higher affinity molecules such as antibodies increase the specificity and sensitivity of assays. Both increased sensitivity and higher affinity can be achieved when multiple copies of a binding molecule are coupled to a flexible backbone. According to one embodiment of the invention, multiple copies of a detection molecule, such as, for example, an antibody or antibody fragment, are covalently linked to a high molecular weight water soluble polymer creates multivalent antibody constructs. The affinity or avidity increases markedly as multivalency increases and also, multiple copies of a signal molecule can be similarly added to the polymer. Thus, the construct comprises multiple copies of detection and signal molecules on a high molecular weight, water soluble, flexible polymer. Broadly, the invention comprises a multiplicity of detection molecules (D) and a multiplicity of signal molecules (S) on a polymer (P), such that P | 2012-08-23 |
20120214188 | LIGHT-ACTIVATED ION CHANNEL MOLECULES AND USES THEREOF - The invention, in some aspects relates to compositions and methods for altering cell activity and function and the use of light-activated ion channels (LAICs). | 2012-08-23 |
20120214189 | Devices and Methods for Pharmacokinetic-Based Cell Culture System - Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device. | 2012-08-23 |
20120214190 | System and method based on blood components for estimating human physiological parameters - A system and method based on blood components for estimating human general physiological parameters comprises determining the predetermined value of general physiological parameters indicative of illness and disease to monitor health status at different time points on the basis of basic physiological parameters indicated as the percentage of a particular cytokine-producing cells in a type of blood cells in a human peripheral blood sample without in vitro culture and with two-stage in vitro cultures in the absence and presence of microbial stimulation after being taken from the subject. | 2012-08-23 |
20120214191 | Methods and Systems for Efficient Processing of Biological Samples - Systems and methods of sample ( | 2012-08-23 |
20120214192 | Method for Producing Antigen-specific B Cell Population - The present invention provides a method for producing an antigen-specific B cell population comprising IgG-positive B cells specific to a specific antigen, the method comprising: culturing IgG-positive B cells together with the specific antigen in the presence of IL-21, while conferring stimulation to the IgG-positive B cells via CD40, a BAFF receptor and Fas; and screening for antigen-specific B cells specific to the specific antigen to obtain an antigen-specific B cell population comprising the IgG-positive B cells specific to the specific antigen. | 2012-08-23 |
20120214193 | METHOD FOR MEASUREMENT OF FLUORESCENCE INTENSITY OF VOLTAGE-SENSITIVE FLUORESCENT DYE - An object of the present invention is to provide a method for increasing the change in the fluorescent intensity as emitted from potential-sensitive fluorochromes depending on a potential or ionic strength change. Another object of the present invention is to measure the changes in the activity potentials of ES cell- or iPS cell-derived cardiomyocytes that have heretofore been impossible to measure. | 2012-08-23 |
20120214194 | PROCESS FOR SYNTHESIZING EPICCONONE ANALOGS - The present invention relates to a process for the total synthesis of epicocconone analogs of formula (I): | 2012-08-23 |
20120214195 | METHOD FOR TISSUE SAMPLE FIXATION - An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed. | 2012-08-23 |
20120214196 | Polypeptides Having Glucoamylase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2012-08-23 |
20120214197 | Polypeptides Having Glucoamylase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2012-08-23 |
20120214198 | ALGACULTURE METHOD - The present invention relates to bioprocess engineering methods in which aqueous phases of anaerobic biologically treated organic suspensions are supplied to algal cultures as media components. The present invention also relates to the use of aqueous phases of anaerobic biologically treated organic suspensions as media components of algal cultures. Additionally, the present invention relates to the use of aqueous phases of anaerobic biologically treated organic suspensions to improve the growth conditions of algae in photobioreactors. Furthermore, the present invention relates to the use of algae for the treatment of aqueous phases of anaerobic biologically treated organic suspensions, in particular of anaerobic biologically treated sewage filtrate. The present invention also relates to bioprocess engineering devices ( | 2012-08-23 |
20120214199 | LIS-PRO PROINSULIN COMPOSITIONS AND METHODS OF PRODUCING LIS-PRO INSULIN ANALOGS THEREFROM - Lis-Pro modified proinsulin sequences that have a modified C-peptide amino acid and/or nucleic acid modification are presented. Methods for producing Lis-Pro insulin analogs are also disclosed. Highly efficient processes for preparing the Lis-Pro insulin analogs and improved preparations containing the Lis-Pro insulin analogs prepared according to the methods described herein are also provided. | 2012-08-23 |
20120214200 | PROKARYOTIC EXPRESSION CONSTRUCT - A pro-polypeptide which is useful for the expression of a polypeptide of interest in a prokaryotic cell. Therefore the pro-polypeptide is fused to the N-terminus of the polypeptide of interest. The pro-polypeptide as reported herein provides for improved expression yields and improves the handling of the fusion polypeptide (downstream processing, purification). For example, efficient endotoxin removal is effected while the protein of interest comprising the pro-polypeptide is bound e.g. to an affinity chromatography material. Thereafter the pro-polypeptide can efficiently be cleaved from the polypeptide of interest by the incorporated protease cleavage site with the cognate protease. | 2012-08-23 |
20120214201 | PROBE INCORPORATION MEDIATED BY ENZYMES - The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs recognized by lipoic acid ligase and lipoic acid ligase mutants. | 2012-08-23 |
20120214202 | RECOMBINANT HOST CELLS HAVING AN INCREASE IN BUOYANT DENSITY - Methods are provided to obtain recombinant microbial cells having at least one genetic modification that increase the buoyant density of a recombinant microbial cell or the buoyant density of inclusion bodies produced within a recombinant microbial cell. Exemplified are genetic modifications that increase the buoyant density of a recombinant microbial cell expressing heterologous peptides and polypeptides. Increasing expression of the genes ysaB, glyQ, glyS or a combination thereof within the recombinant microbial cell produces cells or inclusion bodies having higher buoyant density. A similar effect was achieved by decreasing or disrupting expression of the endogenous gltA gene. Increases in buoyant density render peptide production more efficient with respect to time and costs. | 2012-08-23 |
20120214203 | Methods for Improving Recombinant Protein Expression - Materials and methods are provided which allowed for increased expression of a transfected gene of interest in a recombinant host cell. | 2012-08-23 |
20120214204 | CELL CULTURE MEDIA FOR UVC EXPOSURE AND METHODS RELATED THERETO - The invention relates to cell culture media optimized for exposure to ultraviolet C (UVC) light exposure and related methods. | 2012-08-23 |
20120214205 | PLANT BIOMASS PRETREATMENT METHOD - A plant biomass pretreatment method which allows prompt pretreatment of plant biomass with simple equipment is provided. The method includes continuously performing in sequence, inside an extruder, pretreatment steps of coarsely crushing the plant biomass to a predefined size or smaller, adding a decomposing agent(s) to the coarsely crushed plant biomass, applying a hot compressed water treatment(s) to the plant biomass with the decomposing agent added thereto, and performing saccharification preparation for mixing the plant biomass with the hot compressed water treatment applied thereto with an enzyme(s) for saccharifying the plant biomass. | 2012-08-23 |
20120214206 | VECTORS FOR MOLECULE DELIVERY TO CD11b EXPRESSING CELLS - The invention relates to a novel use of a | 2012-08-23 |
20120214207 | METHODS AND SYSTEMS FOR FAST PCR HEATING - A microplate for polymerase chain reaction (PCR) comprises a substrate having a metallic material for heating PCR samples, and a barrier layer disposed adjacent to the substrate. In some cases, the barrier layer is formed of a first polymeric material. The microplate includes one or more wells for containing PCR samples. The one or more wells are formed of a second polymeric material sealed to the barrier layer. In some cases, the substrate can provide a PCR ramp rate of at least about 5° C./second. | 2012-08-23 |
20120214208 | FUSION POLYPEPTIDES AND USES THEREOF - The invention relates to fusion polypeptides comprising a polynucleotide-binding domain, such as a DNA-binding domain, and a ligase domain, such as a DNA ligase domain, methods for the production of such fusion polypeptides, and uses of the fusion polypeptides, for example in a range of molecular biological techniques as well as applications in the diagnostics, protein production, pharmaceutical, nutraceutical and medical fields. | 2012-08-23 |
20120214209 | Methods For Producing End-Products From Carbon Substrates - The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction of the substrate. | 2012-08-23 |
20120214210 | B-GLUCANASE AND XYLANASE PREPARATION METHOD USING WHEAT BRAN, AND LIQUID CULTURE MEDIUM - To produce cellulase having excellent ability to decompose cellulosic resources containing xylan at low cost. | 2012-08-23 |
20120214211 | Process for the Fermentative Preparation of Organic Chemical Compounds Using Coryneform Bacteria in which the SugR Gene is Present in Attenuated Form - The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds. | 2012-08-23 |
20120214212 | Expression and application of recombinant FAEES in algae as a novel method to produce biodiesel in vivo - This discovery is related to the production of bioenergy fuels in vivo, specifically related to the production of biodiesel fuels using algae. We express FAEES (fatty acid ethyl ester synthase) in algae, and use the recombinant FAEES (fatty acid ethyl ester synthase) in the algae to synthesize biodiesel, fatty acid ethyl ester or fatty acid methyl ester, in vivo from fatty acids in the presence of ethanol/or methanol. | 2012-08-23 |
20120214213 | RECOMBINANT HOSTS AND METHODS FOR MANUFACTURING POLYHYDROXYALKANOATE - Known attempts using engineered bacteria to produce P(3HB-co-4HB) with carbon sources that are structurally unrelated to 4-hydroxybutyrate resulted in relatively low 4HB monomer content of 1.5 to 5 mol %. The current invention provides recombinant hosts for producing P(3HB-co-4HB) wherein the plasmid including succinate semialdehyde dehydrogenase gene (sucD gene) and 4-hydroxybutyrate dehydrogenase gene (4hbD gene) further includes pyruvate decarboxylase promoter (P | 2012-08-23 |
20120214214 | TRANSFORMANT AND PROCESS FOR PRODUCTION THEREOF, AND PROCESS FOR PRODUCTION OF LACTIC ACID - The present invention relates to a transformant, containing a lactate dehydrogenase gene which is introduced into | 2012-08-23 |
20120214215 | PACKED BED SCRUBBER USING A FUSEL OIL SOLVENT - A two stage scrubber process has a first stage removing the hazardous air pollutants and recovering the majority of the ethanol. A second stage uses water as the scrubbing solvent to recover any residual ethanol that is stripped from the first stage. | 2012-08-23 |
20120214216 | Biomass Pretreatment Process - A process is described for pretreating lignocellulosic biomass. The process comprises swelling the lignocellulosic biomass with an aqueous liquid. The pretreated lignocellulosic biomass may be used as a feedstock for the enzymatic conversion to ethanol, or in a thermal conversion. process to produce bio-oil. The pretreatment results in a greater yield and, in the case of a thermal conversion process, a better quality of the bio-oil. The pretreatment process may be used to adjust the composition and amount of inorganic material present in the lignocellulosic biomass material. | 2012-08-23 |
20120214217 | IN SITU TISSUE ENGINEERING USING MAGNETICALLY GUIDED THREE DIMENSIONAL CELL PATTERNING - Methods are provided for the three dimensional manipulation of cells, and for the formation of an organized engineered cell tissue. Also provided are the organized engineered cell tissues produced by the methods. In one method, a plurality of magnetically labeled cells are mixed with a cross-linkable hydrogel to form a cell-hydrogel mixture, the at least a portion of the plurality of magnetically labeled cells are manipulated with a magnetic field to arrange the magnetically labeled cells into a specific cellular arrangement, and the hydrogel is crosslinked to form the organized engineered cell tissue. The approach presented herein offers a means to circumvent the deficiencies in the field of regenerative medicine, and allows for the production of organized tissues in situ with specific cellular organizations that mimic the native tissue. | 2012-08-23 |
20120214218 | TRANSFECTION WITH MAGNETIC NANOPARTICLES AND ULTRASOUND - The invention includes a magnetic nanoparticle molecular delivery vehicle to be used for transfection and delivery of therapeutic molecules across cell membranes and to specific sites in the body, using magnetic forces and ultrasound. | 2012-08-23 |
20120214219 | SEPARATION OF A TARGET SUBSTANCE FROM A FLUID OR MIXTURE USING ENCAPSULATED SORBENTS - Method and apparatus for separating a target substance from a fluid or mixture. Capsules having a coating and stripping solvents encapsulated in the capsules are provided. The coating is permeable to the target substance. The capsules having a coating and stripping solvents encapsulated in the capsules are exposed to the fluid or mixture. The target substance migrates through the coating and is taken up by the stripping solvents. The target substance is separated from the fluid or mixture by driving off the target substance from the capsules. | 2012-08-23 |
20120214220 | XYLANASE COMPOSITION AND METHOD FOR MANUFACTURING THE SAME - A xylanase composition and a method for manufacturing the xylanase composition are provided, wherein the xylanase composition comprises a xylanase and a stabilizer, and the xylanase is from an anaerobic fungus, the stabilizer comprises a polyol, and the content of the polyol is at least 40 wt %, based on the total weight of the xylanase composition. | 2012-08-23 |
20120214221 | Methods For Monitoring Multiple Gene Expression - The present invention relates to methods for monitoring differential expression of a plurality of genes in a first | 2012-08-23 |
20120214222 | METHOD FOR MANUFACTURING A DEVICE FOR REGENERATING BIOLOGICAL TISSUES, PARTICULARLY FOR REGENERATING TISSUES OF THE CENTRAL NERVOUS SYSTEM - A method for manufacturing a device for regenerating biological tissues, particularly for regenerating tissues of the central nervous system, and a device that can be manufactured with said method, the device comprising an outer sheath based on collagen which is substantially tubular and can be interposed between the endings of a biological tissue to be regenerated, and at least one supporting element based on collagen, which is accommodated inside the outer sheath. | 2012-08-23 |
20120214223 | Worm Culture Systems - Devices and methods are disclosed for the containment and culture of worms, and the preparation of composts, vermicomposts, and castings from organic and inorganic wastes. | 2012-08-23 |
20120214224 | Flow based clinical analysis - Values of clinical properties are normally measured by taking a sample from a patient, mixing an aliquot with a reagent, placing the mixture into a selected instrument, and measuring a property. If another property is required, another measurement sequence must be created. This can be efficient on a large scale, for example in a centralized laboratory, but is inefficient on a small scale. It is shown that by using measurement systems based on manipulation of flowing streams, clinical assays can be performed by a hand held device. This flow based system allows complex assays to be performed in remote locations with automated portable instruments that can be flexible enough to conduct a wide variety of assays. | 2012-08-23 |
20120214225 | CELL INCUBATOR AND INCUBATION CONDITION MONITORING SYSTEM - A cell incubator includes: a culture cell accommodating section which accommodates cells to be cultured and a culture solution; and an RFID tag which is attached to the culture cell accommodating section and which is configured to transmit predetermined information to a communicating apparatus in response to reception of a signal that is wirelessly transmitted from the communicating apparatus. | 2012-08-23 |
20120214226 | INSERT FOR CELL CULTURES - An insert for cell cultures has a hollow housing ( | 2012-08-23 |
20120214227 | APPARATUS FOR PREPARING CYTOLOGICAL SPECIMENS - A handheld apparatus for preparing a specimen slide includes a handle, a filter holder assembly coupled to and extending from the handle; and a slide holder assembly coupled to and extending from the handle spaced apart from the filter holder assembly, wherein the slide holder assembly comprises a plurality of positioning members movably coupled to one another, and a slide holder movably coupled to one of the positioning members to allow a slide mounted on the slide holder to make rolling contact with an outward facing surface of a filter mounted on the filter holder assembly. | 2012-08-23 |
20120214228 | TAL EFFECTOR-MEDIATED DNA MODIFICATION - Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided. | 2012-08-23 |
20120214229 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 2012-08-23 |
20120214230 | CELL CULTURE/HANDLING PRODUCT AND METHOD FOR PRODUCTION AND USE THEREOF - The present invention relates to a fast a simple coating procedure for coating of cell culture and/or handling surfaces to prevent cell adhesion and growth. The invention relates to a cell culture/handling product coated with phenyl dextran, as well as methods of producing and using it. | 2012-08-23 |
20120214231 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 2012-08-23 |
20120214232 | METHODS OF CULTURING CELLS IN A MEDIUM COMPRISING TRANSFORMING GROWTH FACTOR BETA 1 AND BASIC FIBROBLAST GROWTH FACTOR - The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells. | 2012-08-23 |
20120214233 | CYSTATIN C AS AN ANTAGONIST OF TGF-BETA AND METHODS RELATED THERETO - Disclosed are Cystatin C (CysC) homologues, including CystC homologues that act as antagonists or inhibitors of transforming growth factor-β (TGF-β). Also disclosed are methods to identify CystC homologues that are antagonists or inhibitors of TGF-β and compositions and therapeutic methods using CystC and homologues thereof to regulate the activity of TGF-β, and TGF-β-mediated tumor malignancy and invasion and other TGF-β-mediated fibrotic or proliferative conditions and diseases. | 2012-08-23 |
20120214234 | iPS CELLS AND METHOD FOR PREPARING THE SAME - The present invention provides a method for producing iPS cells, comprising reacting cells with at least one connexin inhibitor and at least one TGFβ signaling inhibitor; iPS cells comprising at least one connexin inhibitor; an iPS cell inducer comprising at least one inhibitor selected from the group consisting of connexin inhibitors and TGFβ signaling inhibitors; a medium for inducing iPS cells, comprising at least one inhibitor selected from the group consisting of connexin inhibitors and TGFβ signaling inhibitors; and a kit for inducing iPS cells, comprising at least one inhibitor selected from the group consisting of connexin inhibitors and TGFβ signaling inhibitors. | 2012-08-23 |
20120214235 | METHODS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISORDERS AND ALZHEIMER'S DISEASE AND IMPROVING NORMAL MEMORY - The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease. | 2012-08-23 |
20120214236 | GENERATING INDUCED PLURIPOTENT STEM CELLS AND PROGENITOR CELLS FROM FIBROBLASTS - The present disclosure provides a method of generating progenitor cells, such as hematopoietic or neural progenitor cells, from fibroblasts, such as dermal fibroblasts, comprising providing fibroblasts that express or are treated with a POU domain containing gene or protein and culturing the cells under conditions that allow production of progenitor cells, without traversing the pluripotent state. Also provided is a method of isolating a subpopulation of fibroblasts with reprogramming potential comprising providing fibroblasts that express an Oct-4-reporter and isolating cells that are positive for the reporter. Further provided is a method of generating reprogrammed fibroblast-derived induced pluripotent stem cells. Also provided are uses and assays of the cells produced by the methods of the disclosure. | 2012-08-23 |
20120214237 | COMPOSITIONS AND METHODS USEFUL FOR CULTURING DIFFERENTIABLE CELLS - The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand. | 2012-08-23 |
20120214238 | MICROBUBBLE DEVICES, METHODS AND SYSTEMS - A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading to a hydrogel is disclosed. Also disclosed are methods for producing hydrogels with microbubbles and for culturing cells using hydrogels with microbubbles. | 2012-08-23 |
20120214239 | PLANT BIOCHEMICAL SYSTEMS AND USES THEREOF - Plants and plant cells including an isolated nucleic acid encoding for prephenate dehydratase, wherein the nucleic acid is operably linked to a promoter such that prephenate dehydratase is expressed at sufficient levels to protect the plant cell from damage from an abiotic or biotic stressor. The abiotic or biotic stressor may include UV radiation, cold, drought, heat, salt, hormones, fungi, bacteria, arthropods, worms and products of biotic organisms. | 2012-08-23 |
20120214240 | VECTORS FOR GENERATING PLURIPOTENT STEM CELLS AND METHODS OF PRODUCING PLURIPOTENT STEM CELLS USING THE SAME - A reprogramming gene-loaded Sendai viral vector comprising Sendai virus genes and reprogramming genes, wherein the Sendai virus genes include an NP gene, P/C gene, M gene, F gene, HN gene and L gene, wherein each of the M gene, the F gene and the FIN gene is from a Sendai virus strain Cl.151-derived gene and wherein at least one of the M gene, the F gene and the HN gene is functionally deleted and the L gene encodes the amino-acid sequence of the L protein in which the amino-acid residue at position 1618 is valine and a method of producing the same. | 2012-08-23 |
20120214241 | ZINC FINGER NUCLEASE MODIFICATION OF LEUCINE RICH REPEAT KINASE 2 (LRRK2) MUTANT FIBROBLASTS AND IPSCS - Disclosed herein are methods and compositions for alteration of an LRRK2 gene in a fibroblast or iPSC. | 2012-08-23 |
20120214242 | CRE-LOX BASED GENE KNOCKDOWN CONSTRUCTS AND METHODS OF USE THEREOF - The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo. | 2012-08-23 |
20120214243 | METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS - Provided are a method of improving iPS cell establishment efficiency, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B to a somatic cell, particularly to a somatic cell on which Lin28 is ineffective or less effective than Lin28B in improving iPS cell establishment efficiency, and a method of producing an iPS cell, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B and a nuclear reprogramming substance to a somatic cell. Also provided are an iPS cell comprising a nucleic acid that encodes Lin28B, that can be obtained by the method of producing an iPS cell, and a method of somatic cell production by forcing the iPS cell to differentiate into a somatic cell. | 2012-08-23 |
20120214244 | METHOD FOR QUANTIFICATION OF CAROTENOID - Provided is a method for quantitative analysis of carotenoids such as β-cryptoxanthin contained in a sample such as citrus fruit or the like which enables simple and accurate quantitative analysis. | 2012-08-23 |
20120214245 | SYSTEMS AND METHODS FOR BREAST CANCER DETECTION AND RISK ASSESSMENT - The invention relates to a simple screening test for neoplasia, a precancerous condition, or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular embodiment, the method involves treating samples of breast fluids with an aldehyde detecting reagent without any prewashing. The appearance in breast fluids of a marker that is detected by an aldehyde detecting reagent, such as a Schiff's reagent, correlates very well with the disease status of the breast cancer subjects from which the fluids were obtained. Screening test kits are also provided. | 2012-08-23 |
20120214246 | System and Method for Extending Dynamic Range for a Detector - A system and method for measuring signals having a wide range of intensity components using detectors adapted for use in biological analysis devices. In certain biological analysis applications, signals emitted by a sample may have intensity components that vary over several orders of magnitude. Measurement of such a signal may yield an acceptable quality for one intensity component at the expense of another component. For example, a detector configured to measure a relatively weak intensity component may cause it to overflow when subjected to a relatively strong intensity component. The detector can be adapted to be operated at different configurations to allow measurements of different components of the signal, and the results can be combined to yield an accurate representation of the signal. | 2012-08-23 |
20120214247 | Early Warning Sulfur Detection Based on Change in Fluorescence Intensity of Polymer-Bound Phosphine Compound - An early warning sulfur detection system for detecting the presence of corrosive gases, especially elemental sulfur (S | 2012-08-23 |
20120214248 | Method of preparing, storing, transporting and testing chlorine dioxide solutions - A method for determining the concentration of chlorine dioxide in a chlorine dioxide solution having the following steps: | 2012-08-23 |
20120214249 | OPTICAL GAS SENSOR FOR USE WITH ELECTRICAL EQUIPMENT AND METHODS OF ASSEMBLING SAME - A method and apparatus for detecting a gas in electrical equipment by coupling a gas detection device to the electrical equipment is provided. The method includes providing an electro-magnetic source, positioning an electro-magnetic detector to receive light emitted from the electro-magnetic source, and positioning a membrane between the electro-magnetic source and the electro-magnetic detector, such that the electro-magnetic detector only receives light from the electro-magnetic source that has been transmitted through the membrane. The method also includes detecting at least one gas, such that detection of at least one gas includes preventing or allowing communication of the electro-magnetic source and the electro-magnetic detector, and emitting a signal, by the electro-magnetic detector, in response to the detection of the at least one gas. | 2012-08-23 |
20120214250 | METHOD AND APPARATUS FOR MEASURING PH OF SOLUTION - A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances ; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored. | 2012-08-23 |
20120214251 | TEST SET FOR A PHOTOMETRIC MEASURING DEVICE AND PHOTOMETRIC MEASURING METHOD FOR A SAMPLE LIQUID - The invention relates to a test set for a photometric measuring device, comprising a mixing container ( | 2012-08-23 |
20120214252 | COMPOSITION, DEVICE AND METHOD FOR COLORIMETRIC DETECTION OF AN ANALYTE USING IMPRINTED POLYMERS AND PHOTOCHROMIC SWITCH MOLECULES - The invention provides various compositions, devices, and methods useful for detecting an analyte by colorimetric readout. The compositions and devices include polymers constructed to have pores specifically imprinted to provide for capture of an analyte in the pores; nanoparticles layered on the polymers; and photochromic optical switch molecules coated on the nanoparticles. Capture of the analyte in the pores of the polymer results in a change in the spatial relation of the nanoparticles layered on the polymer, which in turn causes the photochromic optical switch molecules coated thereon to undergo a change in energy state corresponding to a visible change in the optical spectra of the photochromic optical switch molecules. | 2012-08-23 |
20120214253 | MACROCYCLIC HOPO CHELATORS - The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. | 2012-08-23 |
20120214254 | Microsystem for Fluidic Applications, and Production Method and Usage Method for a Microsystem for Fluidic Applications - A microsystem for fluidic applications includes a substrate with a reservoir, a first microchannel, connected to the reservoir, and a second microchannel, separated from the first microchannel by a web. The microsystem furthermore has an elastic film on the substrate, which film has a joint to the substrate around the reservoir and seals the reservoir. Here, the joint has a permanent joining area and, on the web, a web joining area that can be broken open and adjoins the permanent joining area at both ends of the web. Such a microsystem forms a processing chip with reagent receptacle. | 2012-08-23 |
20120214255 | METHODS AND COMPOSITIONS FOR ASSAYING A SAMPLE FOR AN AGGREGANT - This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein. | 2012-08-23 |
20120214256 | METHOD OF ANALYSIS OF GENETIC MARKERS - A method of analyzing genetic markers includes binding a set of probes to a segment of single stranded nucleic acids. The segment of single stranded nucleic acids includes a repeat region formed of at least two of a repeat unit. The repeat unit can include at least two nucleic acids. The set of probes includes a first probe complementary to the repeat unit. The method can further include directing the segment through a nanopore device and measuring a signal through the nanopore device. The signal can be indicative of the number of repeat units. | 2012-08-23 |
20120214257 | Reagent Kit for Determining an Analyte in a Sample by Agglutination - A reagent kit for determining an analyte in a sample by agglutination includes a first reagent containing a first specific binding substance that is a substance that can specifically bind to the analyte; and a second reagent containing microparticles having a second specific binding substance bound thereto, the second specific binding substance being a monoclonal antibody against the first specific binding substance. | 2012-08-23 |
20120214258 | Die Bonder and Semiconductor Manufacturing Method - The present invention provides a reliable die bonder that can accurately bond a die and a semiconductor manufacturing method. The present invention is provided with a bonding head that adsorbs a die from a wafer and bonds it to a substrate, a positioning mechanism that is provided with a first adjustment mechanism that positions a position of the die at predetermined accuracy, and positions the bonding head, a positioning controller that controls the positioning mechanism and a second adjustment mechanism that is provided to the bonding head, and adjusts a position of the die at higher accuracy than the first adjustment mechanism. | 2012-08-23 |
20120214259 | OXYGEN DIFFUSION EVALUATION METHOD OF OXIDE FILM STACKED BODY - Experience shows that, in a material containing oxygen as a main component, an excess or deficiency of trace amounts of oxygen with respect to a stoichiometric composition, or the like affects properties of the material. An oxygen diffusion evaluation method of an oxide film stacked body includes the steps of: measuring a quantitative value of one of oxygen isotopes of a substrate including a first oxide film and a second oxide film which has an existence proportion of an oxygen isotope different from an existence proportion of an oxygen isotope in the first oxide film in a depth direction, by secondary ion mass spectrometry; and evaluating the one of the oxygen isotopes diffused from the first oxide film to the second oxide film. | 2012-08-23 |
20120214260 | Semiconductor Surface Modification - Methods, systems, and devices associated with surface modifying a semiconductor material are taught. One such method includes providing a semiconductor material having a target region and providing a dopant fluid layer that is adjacent to the target region of the semiconductor material, where the dopant fluid layer includes at least one dopant. The target region of the semiconductor material is lased so as to incorporate the dopant or to surface modify the semiconductor material. During the surface modification, the dopant in the dopant fluid layer is actively replenished. | 2012-08-23 |
20120214261 | TEST APPARATUS, TEST METHOD AND MANUFACTURING METHOD - Provided is a test apparatus for testing a device under test, comprising a dicing section that dices a wafer on which a plurality of devices under test are formed to separate each of the devices under test; a test packaging section that packages each of the devices under test resulting from the dicing by the dicing section in an individual test package; a testing section that tests the devices under test packaged in the test packages; a removing section that removes the devices under test that have been tested from the test packages; and a commercial packaging section that packages the devices under test removed from the test packages in commercial packages. | 2012-08-23 |
20120214262 | Embedded Semiconductor Device Including Phase Changeable Random Access Memory Element and Method of Fabricating the Same - Disclosed are an embedded semiconductor device including a phase changeable random access memory element and a method of fabricating the same. A semiconductor chip including a main memory element and a supplementary memory element is integrated on a substrate, intrinsic chip data are obtained by electrically testing the semiconductor chip, and the semiconductor chip is packaged. The intrinsic chip data are written into the supplementary memory element before the packaging of the semiconductor chip, and a memory layer of the supplementary memory element is formed of a material exhibiting an improved data retention property under thermal environmental conditions as compared with a memory layer of the main memory element. | 2012-08-23 |
20120214263 | Fabrication System and Manufacturing Method of Light Emitting Device - The present invention provides a vapor deposition method and a vapor deposition system of film formation systems by which EL materials can be used more efficiently and EL materials having superior uniformity with high throughput rate are formed. According to the present invention, inside a film formation chamber, an evaporation source holder in a rectangular shape in which a plurality of containers sealing evaporation material is moved at a certain pitch to a substrate and the evaporation material is vapor deposited on the substrate. Further, a longitudinal direction of an evaporation source holder in a rectangular shape may be oblique to one side of a substrate, while the evaporation source holder is being moved. Furthermore, it is preferable that a movement direction of an evaporation source holder during vapor deposition be different from a scanning direction of a laser beam while a TFT is formed. | 2012-08-23 |
20120214264 | MANUFACTURING METHOD FOR LED PACKAGE - The disclosure provides a manufacturing method for an LED package. A first luminescent conversion layer comprising one first luminescent conversion element is located on an LED chip, wherein the first luminescent conversion element is precipitated via centrifugation around the LED chip without sheltering the LED chip. Thereafter, a second luminescent conversion layer is located on the first luminescent conversion layer. The second luminescent layer has a second luminescent conversion element which has an excited efficiency lower that that of the first luminescent conversion element. | 2012-08-23 |
20120214265 | METHOD FOR FORMING COATING FILM ON FACET OF SEMICONDUCTOR OPTICAL DEVICE - The method includes the steps of preparing an epitaxial wafer by forming a multilayer semiconductor structure on a main surface of a substrate; forming stripe electrodes and bonding pads on the multilayer semiconductor structure with the bonding pads being respectively electrically connected to the stripe electrodes; forming a projection portion on the multilayer semiconductor structure; forming laser diode (LD) bars by cutting the epitaxial wafer; arranging the LD bars on a support surface such that a side surface thereof is oriented normal to the support surface, and disposing spacers between the LD bars; and forming a coating film on the side surface. The projection portion has a height, measured from the main surface of the substrate, greater than a height of the stripe electrodes. Furthermore, the laser diode bar has at least one projection portion. | 2012-08-23 |
20120214266 | MANUFACTURING METHOD OF NITRIDE SEMICONDUCTOR LIGHT EMITTING ELEMENTS - A manufacturing method of nitride semiconductor light emitting elements, which can reliably form a mechanically stable wiring electrode leading from a light emitting element surface. A structure protective sacrifice layer is formed around a first electrode layer on a device structure layer beforehand, and after separation of the device structure layer into respective portions for the light emitting elements, the resultant is stuck to a support substrate. Subsequently, forward tapered grooves reaching the structure protective sacrifice layer are formed, and the inverse tapered portion formed outward of the forward tapered groove is lifted off in a lift-off step. Thus, an insulating layer is formed on the forward tapered side walls of the light emitting element, and a wiring electrode layer electrically connected to the second electrode layer on the principal surface of the light emitting element is formed on the insulating layer. | 2012-08-23 |
20120214267 | ROUGHENING METHOD AND METHOD FOR MANUFACTURING LIGHT-EMITTING DIODE HAVING ROUGHENED SURFACE - The present invention relates to a novel method for roughening an epitaxy structure layer, including: providing an epitaxy structure layer; and etching a surface of the epitaxy structure layer by an excimer laser having an energy density of 1000 mJ/cm | 2012-08-23 |
20120214268 | GROUP-III NITRIDE SEMICONDUCTOR LASER DEVICE, AND METHOD FOR FABRICATING GROUP-III NITRIDE SEMICONDUCTOR LASER DEVICE - A method of fabricating a III-nitride semiconductor laser device includes: preparing a substrate product, where the substrate product has a laser structure, the laser structure includes a semiconductor region and a substrate of a hexagonal III-nitride semiconductor, the substrate has a semipolar primary surface, and the semiconductor region is formed on the semipolar primary surface; scribing a first surface of the substrate product to form a scribed mark, the scribed mark extending in a direction of an a-axis of the hexagonal III-nitride semiconductor; and after forming the scribed mark, carrying out breakup of the substrate product by press against a second region of the substrate product while supporting a first region of the substrate product but not supporting the second region thereof, to form another substrate product and a laser bar. | 2012-08-23 |
20120214269 | TETRAPHENYLSILANE COMPOUNDS SUITABLE AS ORGANIC HOLE-TRANSPORT MATERIALS - A tetraphenylsilane compound suitable as an organic hole-transport material is represented by a formula: | 2012-08-23 |
20120214270 | PROCESS FOR THE PRODUCTION OF SOLAR CELLS COMPRISING A SELECTIVE EMITTER - The present invention relates to a process for the production of solar cells comprising a selective emitter using an improved etching-paste composition which has significantly improved selectivity for silicon layers | 2012-08-23 |
20120214271 | MANUFACTURE METHOD FOR PHOTOVOLTAIC MODULE - The invention permits a plurality of strips of resin adhesive film having a desired width and unwound from a single feeding reel to be simultaneously pasted on a solar cell. For this purpose, the invention comprises the steps of: unwinding a resin adhesive film sheet from a reel on which the resin adhesive film sheet is wound; splitting the unwound resin adhesive film into two or more film strips in correspondence to lengths of wiring material to bond; pasting the strips of resin adhesive film on an electrode of the solar cell; and placing the individual lengths of wiring material on the electrode of the solar cell having the plural strips of resin adhesive film pasted thereon and thermally setting the resin adhesive film by heating so as to fix together the electrode of the solar cell and the wiring material. | 2012-08-23 |
20120214272 | METHOD OF MANUFACTURING ORGANIC THIN FILM SOLAR CELL - Certain embodiments provide a method of manufacturing an organic thin film solar cell comprising forming, on a first electrode, a first transport layer having an uneven pattern and a photoelectric conversion layer provided on a surface of the uneven pattern, forming a second transport layer on a second electrode, and bringing the uneven pattern having the photoelectric conversion layer is formed thereon into contact with the second transport layer to mold the second transport layer. | 2012-08-23 |
20120214273 | ANGLED MULTI-STEP MASKING FOR PATTERNED IMPLANTATION - An improved method of tilting a mask to perform a pattern implant of a substrate is disclosed. The mask has a plurality of apertures, and is placed between the ion source and the substrate. The mask and substrate are tilted at a first angle relative to the incoming ion beam. After the substrate is exposed to the ion beam, the mask and substrate are tilted at a second angle relative to the ion beam and a subsequent implant step is performed. Through the selection of the aperture size and shape, the cross-section of the mask, the distance between the mask and the substrate and the number of implant steps, a variety of implant patterns may be created. In some embodiments, the implant pattern includes heavily doped horizontal stripes with lighter doped regions between the stripes. In some embodiments, the implant pattern includes a grid of heavily doped regions. | 2012-08-23 |
20120214274 | Method for Forming A Solar Cell With Tree-Like Nanostructure - The present invention discloses a solar cell having a multi-layered structure that is used to generate, transport, and collect electric charges. The multi-layered nanostructure comprises a cathode, a conducting metal layer, a photo-active layer, a hole-transport layer, and an anode. The photo-active layer comprises a tree-like nanostructure array and a conjugate polymer filler. The tree-like nanostructure array is used as an electron acceptor while the conjugate polymer filler is as an electron donor. The tree-like nanostructure array comprises a trunk part and a branch part. The trunk part is formed in-situ on the surface of the conducting metal layer and is used to provide a long straight transport pathway to transport electrons. The large contact area between the branch part and the conjugate polymer filler provides electron-hole separation. | 2012-08-23 |
20120214275 | OPTICALLY CONTROLLED SILICON CARBIDE AND RELATED WIDE-BANDGAP TRANSISTORS AND THYRISTORS - An optically active material is used to create power devices and circuits having significant performance advantages over conventional methods for affecting optical control of power electronics devices and circuits. A silicon-carbide optically active material is formed by compensating shallow donors with the boron related D-center. The resulting material can be n-type or p-type but it is distinguished from other materials by the ability to induce persistent photoconductivity in it when illuminated by electromagnetic radiation with a photon energy in excess of the threshold energy required to photoexcite electrons from the D-center to allowed states close to the conduction band edge, which varies from polytype to polytype. | 2012-08-23 |
20120214276 | SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SEMICONDUCTOR DEVICE - An object is to provide a semiconductor device provided with a thin film transistor having excellent electric characteristics using an oxide semiconductor layer. An In—Sn—O-based oxide semiconductor layer including SiO | 2012-08-23 |
20120214277 | SEMICONDUCTOR DEVICE - A method of manufacturing a semiconductor device is disclosed. One embodiment includes placing multiple semiconductor chips onto a carrier, each of the semiconductor chips having a first face and a second face opposite to the first face. An encapsulation material is applied over the multiple semiconductor chips and the carrier to form an encapsulating body having a first face facing the carrier and a second face opposite to the first face. A redistribution layer is applied over the multiple semiconductor chips and the first face of the encapsulating body. An array of external contact elements are applied to the second face of the encapsulating body. | 2012-08-23 |
20120214278 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - A method of manufacturing a semiconductor device comprises the steps of (a) applying a resin member onto a front surface of a semiconductor wafer having an uneven structure on the front surface thereof, and (b) flattening a surface of the resin member by heating the resin member, and in the method, the resin member is formed also on a side surface of the semiconductor wafer. The method further comprises the steps of (c) performing a thinning process for the semiconductor wafer on a back surface thereof after the step (b), and (d) removing the resin member from the semiconductor wafer after the step (c). By the method, it is possible to uniformize the thickness of a semiconductor wafer which is thinned and reduce the number of foreign matters remaining on a surface of the semiconductor wafer. | 2012-08-23 |
20120214279 | METHOD OF MANUFACTURING SEMICONDUCTOR CHIP STACK - A method of manufacturing a semiconductor chip stack includes providing a circuit layout of a function device, the circuit layout further comprising a first device layout and a second device layout, and an integration density of the first device layout is larger than an integration density of the second device layout; defining a plurality of first chip regions on a first wafer and forming the first device layout in each first chip region; defining a plurality of second chip regions on a second wafer and forming the second device layout in each second chip region; forming a plurality of first TSVs in each first wafer for electrically connecting the first device layout and the second device layout; and respectively cutting the first wafer and the second wafer to form a plurality of first chips and a plurality of second chips. | 2012-08-23 |
20120214280 | HEAT SINK FOR INTEGRATED CIRCUIT DEVICES - A resistor with heat sink is provided. The heat sink includes a conductive path having metal or other thermal conductor having a high thermal conductivity. To avoid shorting the electrical resistor to ground with the thermal conductor, a thin layer of high thermal conductivity electrical insulator is interposed between the thermal conductor and the body of the resistor. Accordingly, a resistor can carry large amounts of current because the high conductivity thermal conductor will conduct heat away from the resistor to a heat sink. Various configurations of thermal conductors and heat sinks are provided offering good thermal conductive properties in addition to reduced parasitic capacitances and other parasitic electrical effects, which would reduce the high frequency response of the electrical resistor. | 2012-08-23 |
20120214281 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - According to one embodiment, a method for manufacturing a semiconductor device includes forming a mask layer containing silicon nitride on a semiconductor layer. The method includes forming a side wall film on a side wall of the mask layer. The method includes etching the semiconductor layer using the mask layer and the side wall film to form a gate trench. The method includes forming a gate electrode in the gate trench. The method includes removing the side wall film and forming a base region and a source region in the semiconductor layer using the mask layer. The method includes forming an interlayer film covering the semiconductor layer, the gate electrode and the mask layer, and containing silicon oxide. The method includes forming a contact trench, by using the interlayer film as a mask, in a portion of the semiconductor layer under a portion where the mask layer is removed. | 2012-08-23 |
20120214282 | CMOS TRANSISTOR USING GERMANIUM CONDENSATION AND METHOD OF FABRICATING THE SAME - Provided is a CMOS transistor formed using Ge condensation and a method of fabricating the same. The CMOS transistor may include an insulating layer, a silicon layer on the insulating layer and including a p-MOS transistor region and an n-MOS transistor region, a first gate insulating layer and a first gate on a channel region of the p-MOS transistor region, and a second gate insulating layer and a second gate on a channel region of the n-MOS transistor region, wherein a source region and a drain region of the p-MOS transistor region may be tensile-strained due to Ge condensation, and the channel region of the n-MOS transistor region may be tensile-strained due to the Ge condensation. | 2012-08-23 |
20120214283 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - Gate electrodes are formed in a high speed transistor forming region, a low leakage transistor forming region, and a medium voltage transistor forming region, respectively. Thereafter, a photoresist film covering the medium voltage transistor forming region is formed. Then, ions of an impurity are implanted into a semiconductor substrate while using the photoresist film and the gate electrodes as a mask, and p-type pocket regions, extension regions, and impurity regions are thereby formed. Subsequently, another photoresist film covering the high speed transistor forming region is formed. Then, ions of an impurity are implanted into the semiconductor substrate while using the other photoresist film and the gate electrodes as a mask, and impurity regions and extension regions are thereby formed. | 2012-08-23 |
20120214284 | METHOD FOR FABRICATING METAL GATE TRANSISTOR AND POLYSILICON RESISTOR - An integrated method includes fabricating a metal gate transistor and a polysilicon resistor structure. A photoresistor layer is defined by an SAB photo mask and covers a part of a high resistance structure of the polysilicon resistor. When the dummy gate of the transistor is etched, the part of the high resistance structure is protected by the patterned photoresistor layer. The polysilicon resistor is formed simultaneously with the transistor. Furthermore, the polysilicon resistor still has sufficient resistance and includes two metal structures for electrical connection. | 2012-08-23 |