33rd week of 2013 patent applcation highlights part 47 |
Patent application number | Title | Published |
20130210069 | BIOLOGICAL STERILIZATION INDICATOR SYSTEM AND METHOD - A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a first “unactivated” position and a second “activated” position. The BI can further include a frangible container containing a liquid and dimensioned to be positioned in the housing. The reading apparatus can be configured to detect activation of the biological sterilization indicator, for example, by detecting that the second portion is in the second position, and/or by detecting that the liquid from the frangible container is present in a specific chamber of the biological sterilization indicator. The method can include positioning the BI in the well of the reading apparatus and detecting activation, for example, by detecting one or more of the above conditions. | 2013-08-15 |
20130210070 | MICROFLUIDIC DEVICE AND METHOD FOR CONTROLLING INTERACTION BETWEEN LIQUIDS - A microfiuidic device comprises a valve having electrically controllable wetting properties. The valve comprises a valve surface arranged in a closed valve space defined by at least the valve surface, a first liquid opening for leading a first liquid to the valve and a second liquid opening for leading a second liquid to the valve. The valve surface, in a first state, is sufficiently hydrophobic to prevent contact between the first liquid and the second liquid. The valve surface, in a second state, is sufficiently hydrophilic to allow contact between the first liquid and the second liquid. A ventilation outlet is provided for allowing gas to escape from the valve space. | 2013-08-15 |
20130210071 | CONSOLIDATED BIOPROCESSING METHOD USING THERMOPHILIC MICROORGANISMS - The present invention is directed to a method of converting biomass to biofuel, and particularly to a consolidated bioproces sing method using a co-culture of thermophilic and extremely thermophilic microorganisms which collectively can ferment the hexose and pentose sugars produced by degradation of cellulose and hemicelluloses at high substrate conversion rates. A culture medium therefor is also provided as well as use of the methods to produce and recover cellulosic ethanol. | 2013-08-15 |
20130210072 | PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS - The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | 2013-08-15 |
20130210073 | METHODS OF INCORPORATING AMINO ACID ANALOGS INTO PROTEINS - The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs. | 2013-08-15 |
20130210074 | EPIGENETIC ENGINEERING - The invention concerns the field of cell culture technology. It concerns production host cell lines with increased expression of ribosomal RNA (rRNA) achieved through reducing expression of NoCR proteins, especially of TIP-5. Those cell lines have improved secretion and growth characteristics in comparison to control cell lines. | 2013-08-15 |
20130210075 | ENHANCED PROTEIN EXPRESSION - The application describes methods to enhance protein production using mammalian cells. Increased production of heterologous protein can be obtained by increasing osmolality and lowering temperature. The method maintains the cell growth rate and provides high product yield. | 2013-08-15 |
20130210076 | CONDITIONED CELL CULTURE MEDIUM COMPOSITIONS AND METHODS OF USE - Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, or formulated with a salve or ointment for topical applications. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium. | 2013-08-15 |
20130210077 | CSNR-DEFICIENT ACTINOBACTERIA FOR THE PRODUCTION OF AN ENZYME HAVING CHITOSANASE ACTIVITY - The present invention relates to genetically modified actinobacteria for the production of an enzyme having chitosanase activity. The genetically modified actinobacteria have a reduced (or abolished) activity of the CsnR polypeptide. Such reduced activity can be obtained by reducing the capacity of expressing the csnR gene, its corresponding transcript or expressing a dominant-negative CsnR polypeptide. Such genetically modified actinobacteria are less dependent (and, in some embodiment, totally independent) on the presence of chitosan in the culture medium for producing an enzyme having chitosanase activity. In addition, the genetically modified bacteria produce less proteases in the culture medium and ultimately provide a chitosanase end-product with higher purity. | 2013-08-15 |
20130210078 | METHODS AND KITS FOR REDUCING NON-SPECIFIC NUCLEIC ACID AMPLIFICATION - Methods and kits for efficient amplification of nucleic acids are provided. The disclosure generally relates to methods and kits for nucleic acid amplification of target nucleic acids of interest. The methods described herein promote the synthesis of the target nucleic acid (i.e., template nucleic acid) by reducing the production of undesirable primer-dimer structures and chimeric nucleic acid products during the amplification process by using novel modified primers. | 2013-08-15 |
20130210079 | REAGENTS AND METHODS FOR AUTOLIGATION CHAIN REACTION - The invention relates to the exponential amplification of specific target nucleic acids. The invention provides methods, reagents and kits for carrying out such exponential amplification via the autoligation chain reaction (ACR). | 2013-08-15 |
20130210080 | PC BOARD-BASED POLYMERASE CHAIN REACTION SYSTEMS, METHODS AND MATERIALS - An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed. | 2013-08-15 |
20130210081 | THERMAL CYCLER AND THERMAL CYCLE METHOD - A thermal cycler ( | 2013-08-15 |
20130210082 | COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS - The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided. | 2013-08-15 |
20130210083 | THERMOSTABLE ENZYME TECHNOLOGY FOR ALGAL BIOCONVERSION - Thermostable enzyme technology for algal bioconversion The present invention relates to thermostable enzyme systems suitable for use in the production of biofuels and bio-products from algae, and to a method of producing energy feedstocks, stocks, specifically (i) fermentable sugars and (ii) lipid fractions from algae, for the production of biofuels such as bioethanol, biobutanol and bio-oils or biodiesel, as well as other value-added biomolecules (e.g. proteins, peptides, oils, pigments, nucleic acids). | 2013-08-15 |
20130210084 | USE OF MAGNESIUM HYDROXIDE FOR PH ADJUSTMENT AND IMPROVED SACCHARIFICATION OF BIOMASS - The present invention provides methods of processing biomass containing a cellulosic material that include contacting the cellulosic material with magnesium hydroxide to adjust the pH of the material before and/or after a high temperature and high pressure pretreatment step. The use of magnesium hydroxide provides a safer alternative to using ammonium hydroxide for pH adjustment, a more stable, buffered environment for improved operability in pH control, with similar or improved conversion of biomass to fermentable sugars, and similar or improved reduction of inhibitors during the subsequent hydrolysis or saccharification process. | 2013-08-15 |
20130210085 | Methods and Systems for Pretreatment of Biomass Solids - A method for the pretreatment of biomass solids includes hydrating the biomass solids to form a biomass slurry, shear treating the biomass solids, and hydrolyzing the biomass solids in the presence of reactive enzymes in a pressure hydrolysis zone. Shear treatment of the biomass solids reduces the particle size of the biomass solids, modifies the particle or slurry morphology, and/or ruptures the cell walls of the biomass solids. The pressure hydrolysis zone includes a high-shear, high-pressure, low-temperature heat exchange and reaction zone and a low-pressure, low-temperature polishing zone. Sugars formed from the biomass solids treated in accordance with the methods described above may be used to produce various biofuels. | 2013-08-15 |
20130210086 | Methods of Degrading or Hydrolyzing a Polysaccharide - The invention provides a method of degrading or hydrolyzing a polysaccharide, preferably cellulose or chitin, comprising contacting said polysaccharide with one or more oxidohydrolytic enzymes, preferably a CBM33 family protein (preferably CBP21) or a GH61 family protein, wherein said degradation or hydrolysis is carried out in the presence of at least one reducing agent and at least one divalent metal ion. A method of producing an organic substance comprising said method is also provided. | 2013-08-15 |
20130210087 | Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same - The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2013-08-15 |
20130210088 | Enzymatic Hydrolysis of Lignocellulosic Material in the Presence of Sulfite, Dithionite and/or Dithiothreitol - A method is provided for improving enzymatic hydrolysis in saccharification of a lignocellulosic material. The method is comprising pretreating the lignocellulosic material to obtain a slurry of pretreated lignocellulosic material; adding at least one reducing agent to the slurry of pretreated lignocellulosic material or the liquid fraction thereof to decrease the enzymatic hydrolysis inhibitory properties of slurry of the pretreated lignocellulosic material or the liquid fraction thereof; and subjecting the slurry of pretreated lignocellulosic material or the liquid fraction thereof to enzymatic hydrolysis in the presence of the at least one reducing agent. | 2013-08-15 |
20130210089 | PROCESS FOR THE PRODUCTION OF SUGARS FROM LIGNOCELLULOSIC BIOMASS PRE-TREATED WITH A MIXTURE OF HYDRATED INORGANIC SALTS AND METALLIC SALTS - The present invention concerns a process for the conversion of lignocellulosic biomass into sugars, comprising at least three steps. The first step is a step for cooking the lignocellulosic biomass in the presence of at least one hydrated inorganic salt mixed with at least one other metallic salt. The second step is a step for separating at least one solid fraction which has undergone the cooking step, and the third step is a step for enzymatic hydrolysis of said solid fraction to convert the polysaccharides into monosaccharides. The sugars obtained thereby can then be fermented into alcohols. | 2013-08-15 |
20130210090 | METHODS OF MAKING NYLON INTERMEDIATES FROM GLYCEROL - Embodiments of the invention relate to the enzymatic conversion of bioderived feedstocks to commercially valuable chemicals. The enzymatic conversions of the embodiments of the invention offer the potential for lower cost routes to these value-added chemicals. Some of the chemicals that are useful include nylon intermediates such as caprolactam, adipic acid, 1,6-hexamethylene diamine; butanediols such as 1,4-butanediol, 1,3-butanediol, and 2,3-butanediol; butanols such as 1-butanol, and 2-butanol; succinic acid, butadiene, isoprene, and 3-hydroxypropanoic acid. | 2013-08-15 |
20130210091 | PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-CARBOXYLIC ACID OR ESTERS THEREOF, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF - Process for the enzymatic synthesis of the compound of formula (I): | 2013-08-15 |
20130210092 | Novel Transaminase, Gene Encoding the Same, and Method Using Them - A method for efficiently producing an optically active amino compound useful as an intermediate for pharmaceutical preparations, agricultural chemicals, or the like, from a ketone compound is provided. Specifically, a polypeptide having high resistance to a water-soluble organic solvent and novel transaminase activity for generating (S)-1-benzyl-3-pyrrolidinone with high optical purity of 93% or more, a gene encoding the same, and a transformant expressing the gene at a high level are also provided herein. | 2013-08-15 |
20130210093 | METHODS FOR PRODUCTION OF ALGAE DERIVED OILS - The present invention comprises a method of producing algae derived oils comprising growing, stressing, and harvesting algae and then extracting total lipids from which specific oil fractions are purified. | 2013-08-15 |
20130210094 | HETEROGENEOUS ENZYMATIC CATALYST, PROCESS FOR PREPARING SAME AND USE FOR CONTINUOUS FLOW ENZYMATIC CATALYSIS - The present invention relates to a heterogeneous enzymatic catalyst consisting of a macroprous silica monolith incorporating an enzyme immobilized by means of a compiling agent, to a process for preparing this enzymatic catalyst, to the use of the catalyst for carrying out chemical reactions by continuous flow heterogeneous enzymatic catalyst and to a process of continuous flow heterogeneous enzymatic catalysis using said catalyst. | 2013-08-15 |
20130210095 | NOVEL STRAINS OF MICROALGAE OF THE GENUS BOTRYOCOCCUS AND METHOD FOR THE CULTURE OF SAID MICROALGAE IN MIXOTROPHIC MODE - Novel strains of microalgae which belong to the | 2013-08-15 |
20130210096 | Methods and Systems for the Production of Hydrocarbon Products - Methods and systems for the production of hydrocarbon products, including providing a substrate comprising CO to a bioreactor containing a culture of one or more micro-organisms; and fermenting the culture in the bioreactor to produce one or more hydrocarbon products. The substrate comprising CO is derived from an industrial process selected from the group comprising steam reforming processes, refinery processes, steam cracking processes, and reverse water gas shift processes. | 2013-08-15 |
20130210097 | GLYCOLIC ACID FERMENTATIVE PRODUCTION WITH A MODIFIED MICROORGANISM - The present invention is related to a method for the fermentative production of glycolic acid, its derivatives or precursors, comprising the culture of an | 2013-08-15 |
20130210098 | ENGINEERED KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe. | 2013-08-15 |
20130210099 | METHOD FOR THE PRODUCTION OF ERYTHRITOL - The invention relates to a method for the production of erythritol, in which erythrose is reduced to erythritol using a NADPH-specific enzyme, wherein the enzyme is an erythrose reductase which was isolated from the group of saprophytes selected from the strains of | 2013-08-15 |
20130210100 | ORGANOSOLV PROCESS - The present disclosure provides an organosolv process. The present process comprises treating a lignocellulosic biomass in the presence of a solvent and under certain conditions to separate at least a part of the lignin from the biomass. | 2013-08-15 |
20130210101 | ENHANCING FERMENTATION OF STARCH- AND SUGAR-BASED FEEDSTOCKS - Provided are methods, systems, and compositions for increasing the rate and/or yield of fermentation processes using blended feedstocks. Also provided are methods, systems, and compositions for decreasing the yield of one or more undesirable products during fermentation. | 2013-08-15 |
20130210102 | METHODS FOR DETOXIFYING A LIGNOCELLULOSIC HYDROLYSATE - The present disclosure relates to methods for detoxifying a hydrolysate obtained from a lignocellulosic biomass and methods of producing ethanol from the detoxified hydrolysate. The present methods provide detoxified hydrolysates in which the quantity of compounds that are deleterious to fermenting microorganisms are substantially reduced relative to the starting hydrolysate and in which the amount of total fermentable sugars loss is minimal. | 2013-08-15 |
20130210103 | METHODS FOR DETOXIFYING A LIGNOCELLULOSIC HYDROLYSATE - The present disclosure relates to methods for detoxifying a hydrolysate obtained from a lignocellulosic biomass and methods of producing ethanol from the detoxified hydrolysate. The present methods provide detoxified hydrolysates in which the quantity of compounds that are deleterious to fermenting microorganisms are substantially reduced relative to the starting hydrolysate and in which the amount of fermentable sugars loss is minimal. | 2013-08-15 |
20130210104 | METHODS OF PRODUCING FOUR CARBON MOLECULES - Disclosed are methods for producing butadiene from one or more of several diverse feedstocks including bioderived feedstocks, renewable feedstocks, petrochemical feedstocks and natural gas. | 2013-08-15 |
20130210105 | Methods and Compositions for the Recombinant Biosynthesis of Terminal Olefins - The present disclosure identifies methods and compositions for modifying microbial cells, such that the organisms efficiently synthesize terminal olefins, and in particular the use of such organisms for the commercial production of propylene and related molecules. | 2013-08-15 |
20130210106 | METHOD FOR PRODUCING HYDROCARBONS FROM BIOMASS OR ORGANIC WASTE - The present invention relates to a method for producing hydrocarbons from biomass or organic waste. The present invention provides: a method for effectively producing diverse hydrocarbons by using a raw material comprising mixed organic acids that can be obtained by anaerobic fermentation which is a fermentation process in biogasification technology; and a method for producing diverse products such as fuel, lube base oil and aromatics by using a raw material comprising mixed organic acids. | 2013-08-15 |
20130210107 | HIGH-EXPRESSION PROMOTER DERIVED FROM KLUYVEROMYCES MARXIANUS - Provided is a novel high-expression promoter, namely a GAL1 promoter, derived from | 2013-08-15 |
20130210108 | METHOD FOR CONTROLLING THE CHAPERONE ACTIVITY OF PEROXIREDOXINS USING IRRADIATION - The present invention relates to a method for increasing chaperone activity by irradiating peroxiredoxin (Prx) proteins. More particularly, the present invention may be useful for preparing recombinant proteins imparting resistance against various environmental stresses by increasing the chaperone activity of peroxiredoxin, since it has been observed that irradiated peroxiredoxin has enhanced chaperone activity characteristics, wherein an α-helix structure decreases while a β-sheet structure increases, from analysis results of a protein structure change and chaperone activity after irradiating two types of peroxiredoxins (2-Cys, 3-Cys) which are two active cysteine motifs of peroxiredoxin. | 2013-08-15 |
20130210109 | Differentiated Pluripotent Stem Cell Progeny Depleted of Extraneous Phenotypes - The invention provides methods for depleting extraneous phenotypes from a mixed population of cells comprising the in vitro differentiated progeny of primate pluripotent stem cells. The invention also provides mixed cell populations enriched for a target cell phenotype where the mixed cell population comprises the differentiated in vitro progeny of primate embryonic stem cells. | 2013-08-15 |
20130210110 | Method for Changing Surface Properties of a Substrate from Immobilized Biomolecules - A method that modifies surface properties of a substrate by manipulating the immobilized biomolecules in mild biological condition. The manipulation comprised steps of: providing a biomolecule combined with at least one ssDNA combined with a first protein through an affinity binding tag; adding a second ssDNA conjugated with a second protein with a concentration greater than that of the first protein; and replacing the first protein on the ssDNA with the second protein through chemical competitive principle. The invention may comprise the steps with proper design of biotinylated DNA probes, the functionalized ssDNA nanotemplates can be recovered to its unbound state through a thermodynamic principle. | 2013-08-15 |
20130210111 | SUBSTRATE FOR IMMOBILIZING FUNCTIONAL SUBSTANCES AND METHOD FOR PREPARING THE SAME - A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain including: a moiety R that is chemically coupled to the substrate, the moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker including at least one nucleophilic group. Methods of preparing the substrate and use of the substrate are also disclosed | 2013-08-15 |
20130210112 | BIOREMEDIATION METHOD FOR ACCELERATED BIOLOGICAL DECOMPOSITION OF PETROLEUM HYDROCARBONS IN SEA ICE-COVERED POLAR REGIONS, AND BACTERIA AND ENZYME MIXTURES AS AGENTS FOR CARRYING OUT SAID METHOD - A bacterial mixture usable in an inoculum usable in a bioremediateion method for accelerated biological degradation of petroleum hydrocarbons in a sea ice-covered polar region includes a plurality of isolated cold-adapted autochthonous bacterial strains. Each of the bacterial strains has petroleum hydrocarbons degrading activity at an ambient temperature of −3° C. and each has a different temperature tolerance range, a different salinity tolerance range, a different petroleum hydrocarbons degradation spectrum, and a different capacity to emulsify oil. | 2013-08-15 |
20130210113 | SMALL MOLECULE DYE CONJUGATES - Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens. | 2013-08-15 |
20130210114 | SYNTHETIC CHLOROPLAST TRANSIT PEPTIDES - This disclosure concerns compositions and methods for targeting peptides, polypeptides, and proteins to plastids of plastid-containing cells. In some embodiments, the disclosure concerns chloroplast transit peptides that may direct a polypeptide to a plastid, and nucleic acid molecules encoding the same. In some embodiments, the disclosure concerns methods for producing a transgenic plant material (e.g., a transgenic plant) comprising a chloroplast transit peptide, as well as plant materials produced by such methods, and plant commodity products produced therefrom. | 2013-08-15 |
20130210115 | Method for Activating Catalyst Using Photothermal Nanomaterials - Disclosed is a method for activating a catalyst using the photothermal effects of photothermal nanomaterials, and more particularly to a method of activating a catalyst at a temperature, at which the catalyst has low or no activity, by irradiating a catalyst-photothermal nanomaterial composite with light. The method can activate the catalyst by increasing only the temperature around the nanomaterials without substantially changing the temperature of the reaction medium. A catalyst that generally has high activity at room temperature can be activated even at low temperature. Catalysts having high activity only under mild conditions are immobilized on photothermal nanomaterials so that they have activity even under low temperature and extreme conditions. The invention is useful when a catalyst substrate unstable at room temperature is used or a catalytic product unstable at room temperature is produced. | 2013-08-15 |
20130210116 | COMPOSITION AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2013-08-15 |
20130210117 | CRYSTALS OF MEMBRANE PROTEINS - A polypeptide in crystalline form comprises a G-protein coupled receptor (GPCR) with an IC3 loop substituted by an amino acid residue sequence of lysozyme. | 2013-08-15 |
20130210118 | POLYPEPTIDES HAVING COLANIC ACID-DEGRADING ACTIVITY - The present disclosure generally relates to polypeptides having colanic acid-degrading activity and methods of using the same. Polynucleotides encoding such polypeptides are also described. The polypeptides may be used, for example, in processes for degrading colanic acid, processes for the removal of endotoxins from biological samples, and processes for purifying plasmid DNA. | 2013-08-15 |
20130210119 | METHOD FOR PRODUCING CELLULOLYTIC AND/OR HEMICELLULOLYTIC ENZYMES - The process for the production of cellulolytic and/or hemicellulolytic enzymes by a cellulolytic and/or hemicellulolytic microorganism according to the present invention comprises at least one phase for growth in the presence of a source of carbon and at least one phase for production in the presence of an inducing substrate, in which said inducing substrate is a mixture comprising 40% to 65% by weight of glucose or cellulosic hydrolysates, 21% to 25% by weight of lactose and 10% to 39% by weight of xylose or a solution of a lignocellulosic hemicellulosic hydrolysate, the sum of these three constituents being equal to 100%. | 2013-08-15 |
20130210120 | Inducible Gene Expression Composition for Using Eukaryotic Pol-2 Promoter-Driven Transcription in Prokaryotes and the Applications Thereof - Eukaryotic protein-coding messenger RNAs and non-coding microRNAs are naturally transcribed by type II RNA polymerases (pol-2) but not prokaryotic RNA polymerases. As a result, current eukaryotic RNA and protein production is performed either using eukaryotic pol-2 promoters in hybridomas or mammalian cells or using prokaryotic promoters in bacterial cells. However, because prokaryotic RNA transcription tends to be error-prone, frequent mutation is a big problem. Also, growing hybridomas or mammalian cells is relatively laborious and costly. To overcome these problems, the present invention provides a novel inducible composition and method for producing eukaryotic RNAs and/or their related peptides/proteins directly using eukaryotic pol-2 promoter-driven gene expression in fast growing bacteria, without the need of changing to prokaryotic promoters or growing hybridomas/mammalian cells. The RNAs and peptides/proteins so obtained can be used to develop drugs, cure diseases, treat tumors/cancers, produce pluripotent stem (iPS) cells, enhance wound healing, and make foods. | 2013-08-15 |
20130210122 | METHOD FOR OPEN DIATOM CULTIVATION - Provided is an open diatom cultivation method where continuous production of one or more selected diatom species achieve dominancy in the production system and that dominancy is maintained. The algae culture solution containing diatoms is first introduced to an open microalgae culture system. Then, carbon dioxide and nutrient salts are added to form a culture solution for diatom cultivation. The method enables industrial scale cultivation of diatoms at economically competitive production cost, with a high cultivation density and for a high production volume. The method also enables continuous stable production of selected diatoms and solves the difficult problem of controlling invading algae by always using the most competitive of local diatoms without imposing a selected algae which may be superior in some localities and under some climate conditions. | 2013-08-15 |
20130210123 | BIOMATERIAL HANDLING DEVICE - A biomaterial handling device is described that will provide for functionality for performing both IVF procedures and washing techniques in a single device. Disclosed embodiments provide increased protection to biomaterial samples during processing and handling. Embodiments of the invention reduce labor intensive processes for both IVF and washing treatments and address reduced risks of contamination of biological samples by providing an increasingly sterile environment. | 2013-08-15 |
20130210124 | DETERMINATION OF CANCER PREDISPOSITION - Disclosed herein are systems and methods for using demethylation of genomic DNA for diagnosing, predicting, and/or monitoring the status or outcome of a neoplasm or a cancer in a subject. | 2013-08-15 |
20130210125 | MICROFLUIDIC CARTRIDGE FOR PROCESSING AND DETECTING NUCLEIC ACIDS - A microfluidic cartridge, configured to facilitate processing and detection of nucleic acids, comprising: a top layer comprising a set of cartridge-aligning indentations, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of Detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a Detection chamber, comprises a turnabout portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region. | 2013-08-15 |
20130210126 | MICROFLUIDIC CARTRIDGE FOR PROCESSING AND DETECTING NUCLEIC ACIDS - A microfluidic cartridge, configured to facilitate processing and detection of nucleic acids, comprising: a top layer comprising a set of cartridge-aligning indentations, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of Detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a Detection chamber, comprises a turnabout portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region. | 2013-08-15 |
20130210127 | SYSTEM AND METHOD FOR PROCESSING AND DETECTING NUCLEIC ACIDS - A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids. | 2013-08-15 |
20130210128 | METHODS AND APPARATUS FOR MEASURING ANALYTES - Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 2013-08-15 |
20130210129 | Unitary Biochip Providing Sample-in to Results-out Processing and Methods of Manufacture - A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided. | 2013-08-15 |
20130210130 | AUTOMATED CELL CULTURE SYSTEM - The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module. | 2013-08-15 |
20130210131 | FILTER DEVICE FOR FACILITATING CHARACTERIZING BEHAVIOR OF CELLS - A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well. | 2013-08-15 |
20130210132 | BIOREACTOR AND METHOD - The bioreactor is for use in performing biological and/or biochemical reactions and includes a vessel, an agitator, a reaction assembly, and a harvesting outlet. The vessel of the bioreactor includes several ports including a mixing port, a reaction port, and a harvesting port. The agitator extends through the mixing port into the vessel while the harvesting outlet extends through the harvesting port and permits the withdrawal of reaction medium to another vessel. The reaction assembly extends through the reaction port into the vessel and has multiple components including a gas conduit adapted to introduce gas into a reaction medium in the vessel, a sampling device adapted to remove a portion of the reaction medium from the vessel without contamination of the remaining reaction medium, and an introduction conduit permitting the introduction of at least the reaction medium into the vessel. | 2013-08-15 |
20130210133 | LOW HEAT CAPACITY COMPOSITE FOR THERMAL CYCLER - Provided is a low heat capacity composite for a thermal cycler . The low heat capacity composite of the present invention is a low heat capacity composite for a thermal cycler capable of overcoming difficulty in manufacture and reproducibility due to uniqueness of the existing PCR thermal cycler only. The low heat capacity composite of the present invention can reduce the cost of raw material and retain excellent heat property due to the improvement in low heat capacity and physical and mechanical properties, thereby remarkably shortening PCR reaction time and saving energy when used as a thermal block for a thermal cycler. | 2013-08-15 |
20130210134 | Hybrid Superparamagnetic Iron Oxide Nanoparticles and Polyethylenimine as a Magnetocomplex for Gene Transfection - Disclosed are the nanoparticle and the method for the same, and the preparing method includes steps of mixing polyethylenimine (PEI) with the poly(acrylic acid)-bound iron oxide (PAAIO) to form a PEI-PAAIO polyelectrolyte complex (PEC) and mixing the PEI-PAAIO PEC with genetic material such as plasmid DNA to form the PEI-PAAIO/pDNA magnetic nanoparticle. The PEI-PAAIO/pDNA magnetoplex is highly water dispersible and suitable for long term storage, shows superparamagnetism, low cytotoxicity, high stability and nice transfection efficiency, and thus the PEI-PAAIO PEC can replace PEI as a non-viral gene vector. | 2013-08-15 |
20130210135 | RECOMBINANT VSV FOR THE TREATMENT OF TUMOR CELLS - The present invention relates to compositions and methods for the treatment of tumor and/or malignant and/or cancerous cells. The present invention provides VSV vectors comprising nucleic acid encoding a cytokine, such as interleukin or interferon, or a suicide gene, such as thymidine kinase, or other biological protein, such as heat shock protein gp96, or endostatin or angiostatin, wherein said VSV vectors exhibit greater oncolytic activity against the tumor and/or malignant and/or cancerous cell than a wild-type VSV vector. The present invention also provides methods of making such vectors, host cells, expression systems, and compositions comprising such VSV vectors, and viral particles comprising such VSV vectors. The present invention also provides methods for producing oncolytic activity in a tumor and/or malignant and/or cancerous cell comprising contacting said cell with a VSV vector of the present invention. The present invention also provides methods for suppressing tumor growth comprising contacting said tumor with a VSV vector of the present invention. The present invention also provides methods for eliciting an immune response to a tumor cell in an individual. | 2013-08-15 |
20130210136 | Methods For Treating Cardio Pulmonary Diseases With NO Group Compounds - Treatment of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction and/or inflammation comprises administering into the lungs as a gas a compound with an NO group which does not form NO | 2013-08-15 |
20130210137 | Methods of Modifying Eukaryotic Cells - A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification. | 2013-08-15 |
20130210138 | SOMATIC CELL REPROGRAMMING - The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The invention also relates to pluripotent cell populations obtained using a reprogramming method. | 2013-08-15 |
20130210139 | PROTEOLIPIDBEADS AND METHOD OF USE THEREOF - The subject matter disclosed in this specification pertains to the transfer of compounds of interest into a target biological cell. Specifically, discrete particles that are surrounded in three dimensions with phospholipid bilayers are provided wherein the compound of interest (e.g.) a protein are free to laterally move within the bilayer. The particles may be embedded within a hydrogel matrix. In some embodiments, stem cells are co-cultured in the hydrogel matrix to facilitate the absorption of the compound of interest. | 2013-08-15 |
20130210140 | CELL CARRIERS AND METHODS FOR CULTURING CELLS - A carrier for growing stem cells is provided, the carrier comprises a substrate comprising one or more outer surfaces; and a hydrophilic, water soluble coating material disposed and dried on one or more of the outer surfaces. The carrier comprises one or more structured indentations on one or more of the outer surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of culturing stem cells and stromal cells using the same carrier are also provided. | 2013-08-15 |
20130210141 | DIFFERENTIATION OF PLURIPOTENT CELLS - Provided herein are methods for the in vitro maintenance, expansion, culture, and/or differentiation of pluripotent cells, such as human embryonic stem cells (hESC) or induced pluripotent cells (iPSC), into hematopoietic precursor cells or endothelial cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the pluripotent cells into hematopoietic precursor cells or endothelial cells. The resulting hematopoietic precursor cells may be further differentiated into various myeloid or lymphoid lineages. | 2013-08-15 |
20130210142 | Methods and Compositions for Enhancing Vascular Access - Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape-retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype. | 2013-08-15 |
20130210143 | NOVEL METHODS FOR PREVENTING OR TREATING DIABETES - The present application relates to an LRH-1 agonist for use in the prevention of progressive loss of pancreatic β-cells. It also relates to an LRH-1 agonist for use in the preservation or restoration of pancreatic β-cells. Further, it relates to an LRH-1 agonist for use in the prevention or treatment of type I diabetes, the increment of survival of pancreatic β-cells, the increment of the performance of pancreatic β-cells, the increment of the survival of a β-cell graft, the in vitro preservation of pancreatic β-cells, maintaining insulin secretion and/or in a method of transplanting pancreatic islet cells. | 2013-08-15 |
20130210144 | PROTEOLYTICALLY RESISTANT HYDROGEN BOND SURROGATE HELICES - The present invention relates to peptidomimetics having a stable, internally constrained protein secondary structure, where the peptidomimetics contain a hydrogen bond surrogate in the internal constraint, and at least one beta amino acid. Methods for promoting cell death using peptidomimetics that inhibit p53/hDM2 are also disclosed. | 2013-08-15 |
20130210145 | GENERATION OF INNER EAR CELLS - Methods for generating cells of the inner ear, e.g., hair cells and supporting cells, from stem cells, e.g., mesenchymal stem cells, are provided, as well as compositions including the inner ear cells. Methods for the therapeutic use of the inner ear cells for the treatment of hearing loss are also described. | 2013-08-15 |
20130210146 | Methods and Compositions for Generation of Induced Pluripotent Stem Cells By RNAA - The present disclosure provides methods for inducing somatic cells to form induced pluripotent stem (iPS) cells. The method includes introducing a small activating RNA (saRNA) molecule into the somatic cell, where the saRNA molecule increases transcription of a transcription factor that induces the formation of induced pluripotent stem cells. The present disclosure also provides compositions and kits comprising a saRNA molecule that increases transcription of a transcription factor that induces the formation of induced pluripotent stem cells. The present disclosure provides iPS cells comprising at least one exogenous saRNA molecule, where the saRNA molecule increases transcription of a transcription factor that induces the formation of induced pluripotent stem cells. | 2013-08-15 |
20130210147 | Bioactive amino acid sequence and use therefrom - Use of the amino acid sequence Har-Gly-Asp (hRGD) as a bioactive sequence in functional peptides to promote cell adhesion, cell growth, and/or cell differentiation, and in the preparation of hydrogels, preferably hydrogels for cell culture. A hydrogel comprising the hRGD sequence, especially a hydrogel wherein the hRGD sequence is part of the hydrogel scaffold. | 2013-08-15 |
20130210148 | CURVED AND FLEXIBLE MICROFLUIDICS - A method of producing curved, folded or reconfigurable structures includes providing a polymer film, exposing the polymer film to at least one of patterned radiation or patterned chemical contact, and conditioning the polymer film subsequent to the exposing. The polymer film includes a polymer that is active to cross-linking of polymer chains in response to the exposing. The exposing is performed such that at least one exposed region of the polymer film develops a gradient in an amount of cross-linking of polymer chains along a cross-sectional direction of the polymer film, and the conditioning of the polymer film removes uncross-linked polymer chains to provide a curved, folded or reconfigurable structure. | 2013-08-15 |
20130210149 | HUMAN G-PROTEIN CHEMOKINE RECEPTOR HSATU68 - Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. | 2013-08-15 |
20130210150 | COMPOSITION FOR INDUCING PLURIPOTENT STEM CELL, AND USE THEREOF - The present invention provides Sendai virus vectors in which genes that encode reprograming factors for inducing pluripotent stem cells are incorporated in a specific order, compositions comprising these vectors for gene delivery to be used in the induction of pluripotent stem cells, and uses thereof. Incorporation of the KLF gene, OCT gene, and SOX gene in a specific order into a single Sendai virus vector successfully and significantly increased the efficiency of pluripotent stem cell induction. Loading multiple reprogramming factors into a single vector can further increase the induction efficiency of pluripotent stem cells while reducing the number of necessary vectors. | 2013-08-15 |
20130210151 | ENDONUCLEASE FOR GENOME EDITING - A chimeric endonuclease is provided comprising the GIY-YIG nuclease domain which is linked to a DNA-targeting domain by a linking domain. The endonuclease is useful in gene editing. | 2013-08-15 |
20130210152 | Chloramphenicol Resistance Selection in Bacillus Licheniformis - The present invention relates to a modified | 2013-08-15 |
20130210153 | DETECTION OF THE INTEGRITY OF A TIGHT, CLOSED, SOFT PLASTIC POUCH FOR RECEIVING AND PROTECTING A PRODUCT OR A BIOPHARMACEUTICAL DEVICE | 2013-08-15 |
20130210154 | HAND-DEVICE, AND METHODS FOR EXAMINING A CORRODIBLE METAL OBJECT FOR CORROSION - A hand-device is described for penetrating a heat-insulating layer of a corrodible metal object and for examining a pipeline for corrosion, preferably for penetrating a heat-insulating layer of a corrodible metal pipeline, with a penetrating body that comprises a pointed section for displacing the insulating layer and a holding section for receiving a driving force, and a detecting device for generating a signal as a response to a stimulus caused by corrosion, wherein the detecting device is arranged proximally to the pointed section of the penetrating body. Corresponding methods as well as uses are also described. | 2013-08-15 |
20130210155 | Methods For Selection Of A Naphthenate Solids Inhibitor And Test Kit, And Method For Precipitating Naphthenate Solids - The present invention relates to a method for identifying an inhibitor to the formation of naphthenate solids in a liquid hydrocarbon including contacting a sample of the liquid hydrocarbon with an inhibitor and a buffered aqueous solution, observing the extent of formation of naphthenate solids, if any, the extent of formation of naphthenate solids being indicative of the effectiveness of the inhibitor, and repeating the steps, if necessary, until a suitable inhibitor is identified. The present invention also relates to a method for identifying an inhibitor to the formation of naphthenate scale in a liquid hydrocarbon system as well as test kits for use in the methods. | 2013-08-15 |
20130210156 | Uniform, Functionalized, Cross-Linked Nanostructures for Monitoring pH - Described herein are optical agents, including compositions, preparations and formulations, for monitoring the pH of a fluid. Optical agents described herein include photonic nanostructures and nanoassemblies including supramolecular structures, such as shell cross-linked micelles, that incorporate at least one linking group comprising one or more photoactive moieties that provide functionality as exogenous agents for a range of pH monitoring applications. Optical agents described herein comprise supramolecular structures having linking groups imparting useful optical and structural functionality. In an embodiment, for example, the presence of linking groups function to covalently cross link polymer components to provide a cross-linked shell stabilized supramolecular structure, and also impart useful optical functionality, for example by functioning as a fluorophore. | 2013-08-15 |
20130210157 | Zn3(BDC)3[Cu(SalPycy)] AND Zn3(CDC)3[Cu(SalPycy)] - ENANTIOPURE MIXED METAL-ORGANIC FRAMEWORKS FOR SELECTIVE SEPARATIONS AND ENANTIOSELECTIVE RECOGNITION - Disclosed herein are mixed metal-organic frameworks, Zn | 2013-08-15 |
20130210158 | QUATERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS - Quaternary nitrogen heterocyclic boronic acid-containing compounds are described, which are sensitive to glucose and fructose, as well as a variety of other physiologically important analytes, such as aqueous chloride and iodide, and a method of using the compounds. Also disclosed is a contact lens doped with the quaternary nitrogen heterocyclic boronic acid-containing compound, and a method of using the doped contact lens to measure the concentration of analyte in tears under physiological conditions. | 2013-08-15 |
20130210159 | METHOD FOR DETERMINING ODOR WHEN USING A SELF-TANNING AGENT - A method for evaluating an odor generated when using a self-tanning agent, wherein at least one compound selected from pyrazine compounds represented by the following general formula (1) is used as an indicator substance: | 2013-08-15 |
20130210160 | METHOD AND DEVICE FOR DETECTING HYDROGEN - The invention relates to a device and to a method for the detection of hydrogen in a gas mixture, wherein the device comprises a catalyst unit which is connected to a source and a supply device for CO and/or CO | 2013-08-15 |
20130210161 | METHOD FOR PREPARING A SAMPLE FOR ANALYSIS - A well plate ( | 2013-08-15 |
20130210162 | ATMOSPHERIC PRESSURE LASER-INDUCED ACOUSTIC DESORPTION CHEMICAL IONIZATION FOR GLOBAL HYDROCARBON ANALYSIS - Systems, devices, and methods, operational at atmospheric pressure, involving a conical member having an outlet positioned relative to an inlet of a mass spectrometer inlet capillary; a tungsten electrode positioned between the conical member and the inlet of the mass spectrometer inlet capillary; a foil membrane disposed within the conical member, the foil membrane having a first surface, and a second surface opposed to the first surface; a laser directing laser pulses at the second surface of the foil membrane to create a shockwave to vaporize one or more analytes deposited on the first surface; a reagent gas inlet stream positioned relative to the foil membrane to pass a reagent gas across the foil member to transport vaporized analytes: away from the foil membrane, through the outlet of the conical member, through a corona discharge generated by the tungsten electrode, and into the inlet capillary of a mass spectrometer. | 2013-08-15 |
20130210163 | ANALYSIS - A method for collecting a sample and/or analysing a sample is provided, together with kits for use therein, in which the method includes using the kit and wherein an identifier is provided on one or more of the devices and/or containers and/or packaging which can be recorded and which is used to link the identity of the identifier for one or more of those identifiers to one or more of the identities for one or more of the other identifiers. In this way, the different devices, containers, pieces of equipment, reagents and stages used in the collection and/or analysis can be linked together for future reference. This ensures the correct processing of the sample and the correct attributing of the end results to it. Checks or other enquiries can be made on each of the different devices etc to validate the results if necessary. | 2013-08-15 |
20130210164 | REDUCING pH EXCURSIONS IN ION EXCHANGE CHROMATOGRAPHY - Provided are methods and compositions for reducing or eliminating pH excursions in cation and anion exchange chromatography. | 2013-08-15 |
20130210165 | Luminescent Lanthanide Chelates Having Three Chromophores and Their Use - The present application discloses a luminescent lanthanide chelate of formula (I) | 2013-08-15 |
20130210166 | Low-Cost Electrode Chip Variants and Methods for Multi Analyte Analysis and Referencing Based on Cathodic Electroluminescence - The invention relates to electrode chip (EChip) cartridge devices which are used in hot electron -induced electro-chemiluminescence (HECL) and electroluminescence (EL) methods and instrumentation based on the electrical excitation of label molecules with subsequent measurement of the luminescence in order to quantitate analyte concentrations in bioaffinity assays, especially outside of central laboratories, but also in rapid screening tests. | 2013-08-15 |
20130210167 | IMMUNOASSAY FOR PYRROLIDINOPHENONES - The invention describes antibodies that bind molecules of the pyrrolidinophenone class of synthetic drugs. The antibodies are derived from novel chemical intermediates, haptens and immunogens and are used in methods and kits to detect and quantify pyrrolidinophenones. | 2013-08-15 |
20130210168 | ASSAY FOR DETECTING FREE LIGHT CHAINS BY CAPILLARY ZONE ELECTROPHORESIS - The invention provides a method detecting free light chains (FLCs) comprising: (i)providing a sample from a subject; (ii)mixing the sample with an anti-FLC specific antibody, or fragments thereof capable of specifically binding the FLC, to form a mixture; (iii)passing the mixture through a capillary tube by capillary zone electrophoresis (CZE); and (iv)detecting the presence of the antibody or fragment thereof after passage through at least a portion of the capillary tube. Capillary tubes for use in CZE and kits comprising capilliary tubes and at least one anti-FLC antibody are also provided. | 2013-08-15 |
20130210169 | MANUFACTURE METHOD FOR SEMICONDUCTOR DEVICE CAPABLE OF PREVENTING REDUCTION OF FERROELECTRIC FILM - A ferroelectric capacitor is formed on a semiconductor substrate, the ferroelectric capacitor comprising a lower electrode, a ferroelectric film and an upper electrode stacked in an order recited. A first capacitor protective film of aluminum oxide having a thickness equal to or thicker than 30 nm is formed covering the ferroelectric capacitor. A first insulating film of silicon oxide is formed on the first capacitor protective film by chemical vapor deposition using high density plasma. | 2013-08-15 |