33rd week of 2015 patent applcation highlights part 9 |
Patent application number | Title | Published |
20150224190 | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the IL-8/CXCR interaction - The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound and (b) a compound which inhibits the interaction between IL-8 and at least one of its receptors for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human. | 2015-08-13 |
20150224191 | Combination Treatment with VEGF-C Antagonists - The invention relates to a method and kit for treating cancer in a human subject, the method comprising administering to the subject in combination therapeutically effective amounts of a VEGF-C antagonist and an anti-neoplastic composition, and the kit comprising a VEGF-C antagonist for administering to the subject in combination with an anti-neoplastic composition. The invention further relates to methods for: increasing the duration of survival of, increasing the progression-free survival of, increasing the duration of response of, or treating, a subject or a group of human subjects susceptible to or diagnosed as having a cancer; or treating a human subject or a group of human subjects having metastatic colorectal cancer, prostate cancer, pancreatic cancer or glioblastoma, the methods comprising administering to the subject or subjects in the group in combination effective amounts of a VEGF-C antagonist and an anti-neoplastic composition. | 2015-08-13 |
20150224192 | Methods and Compositions for Treatment of Human Immunodeficiency Virus Infection with Conjugated Antibodies or Antibody Fragments - The present invention concerns methods and compositions for treatment of HIV infection in a subject. The compositions may comprise a targeting molecule against an HIV antigen, such as an anti-HIV antibody or antibody fragment. The anti-HIV antibody or fragment may be conjugated to a variety of cytotoxic agents, such as doxorubicin. In a preferred embodiment, the antibody or fragment is P4/D10. Other embodiments may concern methods of imaging, detection or diagnosis of HIV infection in a subject using an anti-HIV antibody or fragment conjugated to a diagnostic agent. In alternative embodiments, a bispecific antibody with at least one binding site for an HIV antigen and at least one binding site for a carrier molecule may be administered, optionally followed by a clearing agent, followed by administration of a carrier molecule conjugated to a therapeutic agent. | 2015-08-13 |
20150224193 | PHOTOREACTIVE REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF - The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function. | 2015-08-13 |
20150224194 | Compositions of Glycopyrronium Salt for Inhalation - A process for preparing dry powder formulations of a glycopyrronium salt for inhalation that have good stability. The process involves (a) micronising a glycopyrronium salt together with an anti-adherent agent, and (b) admixing carrier particles to form the dry powder formulation. | 2015-08-13 |
20150224195 | TOPICAL ECTOPARASITICIDE COMPOSITION - A topical ectoparasiticide composition comprising an Insect Growth Regulator and at least one C | 2015-08-13 |
20150224196 | AQUEOUS PHARMACEUTICAL COMPOSITIONS CONTAINING BORATE-POLYOL COMPLEXES - The present invention is directed to the provision of multi-dose, ophthalmic compositions. The compositions possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements, as well as similar preservative standards (e.g., EP and JP). The compositions include at two different polyols in conjunction with borate and a low concentration of benzalkonium chloride. | 2015-08-13 |
20150224197 | INHALATION COMPOSITIONS - The invention relates to pharmaceutical powder compositions administered by means of inhalers. More particularly, it relates to pharmaceutical powder compositions having the content uniformity and the desired stability used in inhaler devices. | 2015-08-13 |
20150224198 | LYOPHILIZED VIRAL FORMULATIONS - Provided herein are lyophilized viral formulations useful for the stabilization and storage of viruses and methods of preparing these formulations. The lyophilized viral formulations described herein include a virus (e.g., a purified virus) and a non-viral composition including excipients. The formulations can be used, for example, to retain the infectivity or immunogenicity of viruses during periods of storage. | 2015-08-13 |
20150224199 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - The present invention discloses pharmaceutical compositions comprising: a compound according to Formula I: | 2015-08-13 |
20150224200 | Drug Delivery Methods, Structures, and Compositions for Nasolacrimal Systems - An implant for insertion into a punctum of a patient comprises a body. The body has a distal end, a proximal end, and an axis therebetween. The distal end of the body is insertable distally through the punctum into the canalicular lumen. The body comprises a therapeutic agent included within an agent matrix drug core. Exposure of the agent matrix to the tear fluid effects an effective therapeutic agent release into the tear fluid over a sustained period. The body has a sheath disposed over the agent matrix to inhibit release of the agent away from the proximal end. The body also has an outer surface configured to engage luminal wall tissues so as to inhibit expulsion when disposed therein. In specific embodiments, the agent matrix comprises a non-bioabsorbable polymer, for example silicone in a non-homogenous mixture with the agent. | 2015-08-13 |
20150224201 | PREPARATION OF ANTIBODY OR AN ANTIBODY FRAGMENT TARGETED IMMUNOLIPOSOMES FOR SYSTEMIC ADMINISTRATION OF THERAPEUTIC OR DIAGNOSTIC AGENTS AND USES THEREOF - A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex. | 2015-08-13 |
20150224202 | FORMULATIONS AND USES FOR MICROPARTICLE DELIVERY OF ZINC PROTOPORPHYRINS - Formulations and methods of use thereof that relate to biocompatible delivery of zinc protoporphyrin (ZnPP) are provided. In some embodiments, the ZnPP is formulated for oral delivery. Formulations may include microparticles of ZnPP, wherein the ZnPP active agent is admixed or coated with a pharmaceutically acceptable stabilizer providing for increased stability to acid conditions and improved solubility at neutral pH. | 2015-08-13 |
20150224203 | Factor VIII Conjugates - The present invention relates to FVIII conjugated to heparosan (HEP) polymers, methods for the manufacture thereof and uses of such conjugates. The resultant conjugates may be used in the treatment or prevention of bleeding disorders such as haemophilia. | 2015-08-13 |
20150224204 | IMMUNOGENIC COMPOSITION - The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype Ia conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype Ib conjugated to a carrier protein; c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein; d) a conjugate that is a capsular saccharide from GBS serotype II conjugated to a carrier protein; and e) a conjugate that is a capsular saccharide from GBS serotype V conjugated to a carrier protein. | 2015-08-13 |
20150224205 | POLYMERIC CONJUGATES OF C-1 INHIBITORS - Polymer conjugates containing a C1-inhibitor having at least one substantially non-antigenic polymer covalently attached to the C1-inhibitor via amino group of the C1 inhibitor are provided. In the polymer conjugates, the substantially non-antigenic polymer is attached to the N-terminal of C1-inhibitor. Alternatively, the substantially non-antigenic polymer is attached to the N-terminal of C1-inhibitor and at least one more of the substantially non-antigenic polymer is attached to lysine and/or histidine of the C1-inhibitor. Furthermore, the polymer conjugates is attached to C1-inhibitor either via permanent or releasable spacers. In addition, methods of making the conjugates as well as methods of treatment using the conjugate of the present invention are also provided. | 2015-08-13 |
20150224206 | N-BOC-DENDRIMERS AND THEIR CONJUGATES - Asymmetrical dendritic compound of the Formula (I) as described herein can contain multiple functional moieties as represented by R | 2015-08-13 |
20150224207 | THIOL-SELECTIVE WATER-SOLUBLE POLYMER DERIVATIVES - The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins. | 2015-08-13 |
20150224208 | NOVEL PRODRUGS FOR SELECTIVE ANTICANCER THERAPY - The present invention provides a compound having the structure: | 2015-08-13 |
20150224209 | LENTIVIRAL VECTOR FOR STEM CELL GENE THERAPY OF SICKLE CELL DISEASE - In various embodiments a recombinant lentiviral vector is provided comprising an expression cassette comprising a nucleic acid construct comprising an anti-sickling human beta globin gene encoding an anti-sickling-beta globin polypeptide comprising the mutations Gly16Asp, Glu22Ala and Thr87Gln, where the lentiviral vector is a TAT-independent and self-inactivating (SIN). In certain embodiments the vector additionally contains one or more insulator elements. The vectors are useful in gene therapy for the treatment of sickle cell disease. | 2015-08-13 |
20150224210 | CARBON NANOMATERIAL, COMPOSITION, CONDUCTIVE MATERIAL, AND METHOD OF PRODUCING THE SAME - Provided are a composition, a conductive material, and a method of manufacturing the same, in which the composition and the conductive material have biocompatibility, can be used in the living body for a long period of time, have superior followability to the shape of wrinkles of an organ or the like, and can form a far superior interface with an organ or the like. The composition includes a carbon nanomaterial that is covered with molecules constituting a hydrophilic ionic liquid, in which the carbon nanomaterial is dispersed in a water-soluble polymer medium, and the carbon nanomaterial is doubly covered with the molecules constituting the ionic liquid and a water-soluble polymer. | 2015-08-13 |
20150224211 | LEUKOCYTES AS DELIVERY CELLS FOR IMAGING AND DISEASE THERAPY - Theranostic methods are described herein, which are useful in diagnosing and/or treating infection, inflammation, and/or cancer. The methods utilize naturally-occurring leukocytes for in situ photodynamic therapy and imaging, and for the delivery of targeted therapies to the infection, inflammation, and/or cancer. | 2015-08-13 |
20150224212 | FERRITIN-BASED TUMOR TARGETING AGENT, AND IMAGING AND TREATMENT METHODS - An MRI contrast material includes tumor-targeting metal-loaded ferritin nanoparticles constructed with genetically modified ferritin coupled to a target-specific agent. Ferritin derived from | 2015-08-13 |
20150224213 | TREATMENT OF NEUROLOGICAL DISORDERS - This invention provides treatment compositions as well as systems and methods of determining and administering an effective amount of treatment for a neurological disorder. The treatment composition can contain a labeled interfering RNA (iRNA) agent capable of decreasing expression of a target RNA associated with the neurological disorder. The methods of the invention include determining an effective amount of a therapeutic composition by introducing a solution containing a tracer into the brain of a mammal. The tracing solution is monitored until a target volume of distribution at steady state distribution is substantially achieved, and the rate of delivery of the therapeutic composition is determined. The therapeutic composition can then be administered at the rate determined by use of the tracing solution. | 2015-08-13 |
20150224214 | SYSTEM AND METHOD FOR DISINFECTING SURFACES IN A ROOM - A method of neutralizing pathogens includes covering a surface to be disinfected with a coating including one or more types of minutely configured particles having a generally high conductivity. The surface is exposed to electromagnetic waves for a duration of time up to three minutes thereby killing the pathogens. | 2015-08-13 |
20150224215 | LYOPHILIZING OR STERILIZING MACHINE WITH MOVEMENT APPARATUS FOR LOADING PLANES - Lyophilizing or sterilizing machine, comprising a lyophilizing or sterilizing chamber, a plurality of loading planes, having a loading surface disposed inside the chamber and overlapping each other, and a movement apparatus to load on and unload from the loading surface of the loading planes, containers the content of which is to be treated in the chamber. The movement apparatus comprises at least one loading/unloading slider mobile on horizontal guides. The loading planes are associated with vertical movement guides. Each of the loading planes comprises at least two opposite lateral flanks, a plurality of through holes being present on at least one of the lateral flanks in order to house the vertical guides. The through holes define a lateral guide solid with the loading plane, at least one through seating being present between said lateral guide and the loading surface to freely house a respective horizontal guide. | 2015-08-13 |
20150224216 | MEASUREMENT OF THE NCG CONCENTRATION IN A STEAM STERILIZER - A method and system for determining steam sterilant quality of a steam sterilizer where the steam sterilant comprises non-condensable gas(es). | 2015-08-13 |
20150224217 | Disposable and Scented Pad - A scented and disposable pad having a plurality of layers including a first layer composed of an absorbent material, a second layer that is a gel layer, and a third layer that is a waterproof layer. The gel layer can be embedded with a fragrance in order to provide a pleasing scent to the user. The pad can be placed underneath one's sheet in between the sheet and the mattress of the user. Alternatively, the pad can be placed between a pillow case and a pillow to provide a soothing scent for relaxation and sleep while laying down. At least one layer is embedded with scented micro beads, wherein the scent can include vanilla, lavender, and other scents to promote sleep and relaxation. | 2015-08-13 |
20150224218 | Photocatalytic Device for Ductless Heating and Air Conditioning Systems - A photocatalytic device comprising Manganese dioxide and Titanium dioxide coated housing, an ultraviolet light source disposed therein, and a plurality of multi-metallic photocatalytic structures, such as hydrated multi-metallic catalyst substrates, is adapted to be deployed in conjunction with the exchange air intake of a mini-split system. The photocatalytic device has (a) Manganese dioxide and Titanium dioxide coated reflector(s) that is/are positioned to reflect ultraviolet light onto the photocatalytic structures. The photocatalytic device may have at least one carbon fiber and/or needle type ionizer disposed in the housing. The photocatalytic device may also have at least one sensor and may be wirelessly coupled to a computing device or controller. | 2015-08-13 |
20150224219 | TREATMENT OF LEG ULCERS USING PLACENTA DERIVED COLLAGEN BIOFABRIC - The present invention provides a method of treating a leg ulcer comprising contacting the leg ulcer with a collagen biofabric. The leg ulcer may be a venous, arterial, diabetic or decubitus (pressure) ulcer. The invention further provides kits comprising one or more pieces of collagen biofabric for the treatment of a leg ulcer. | 2015-08-13 |
20150224220 | Antimicrobial Silver Iodate - The present invention is silver (I) periodate compounds and their use in preventing or reducing microbial contamination. The invention includes gels, coatings, and articles of manufacture having a surface contacted or coated with a gel comprising an antimicrobial silver (I) compound. Methods of treatment are also disclosed. | 2015-08-13 |
20150224221 | METHOD FOR PREPARING MICROSPHERES FOR EMBOLI, AND METHOD FOR PREPARING MICROSPHERES TO WHICH DRUG-CONTAINING CARRIER IS BOUND - This disclosure relates to microspheres emboli and method of making them. The recoverability of lyophilized microspheres is optimized by adding trehalose prior to lyophilization of the microspheres and vortexing the lyophilized microspheres. The optimization can be useful in maintaining physical properties, shapes, and the drug release level of the microspheres for emboli. Chitosan microspheres can be useful in stably causing emboli in blood vessels, and precisely adjusting the release of a drug, and thus can be used in anticancer treatment. | 2015-08-13 |
20150224222 | MATERIAL TO FORM A HYDROGEL - A soft film, a sponge, or a sheet in the dried state is provided, which is capable of forming a hydrogel absorbing water or blood. The film is obtainable by preparing a film-state material in the dried state from either a solution of poly(acrylic acid) or a solution of polyvinylpyrrolidone, and bringing the film-state material into contact with the other remaining solution, and then drying or freeze-drying it. | 2015-08-13 |
20150224223 | SILVER CONTAINING WOUND DRESSING - A wound dressing having anti-microbial activity comprises a first fibre capable of bonding with silver (1) cations. The wound dressing comprises a blend of the first fibre to which silver (1) cations are bonded and a second fibre which is substantially free from silver. The wound dressing comprises from 0.01 to 5.0 percent by weight of silver (1) cations, based on the weight of fibre. | 2015-08-13 |
20150224224 | BIOACTIVATED MATERIAL - The present invention generally relates to the field of bone substitute materials, and particularly to a bone substitute material that is bioactivated. More specifically, the present invention relates to a particular agent comprising citrate, citric acid, monobasic sodium phosphate, dextrose, and adenine for use in improving or promoting osseointegration of a bone substitute material, to a bone substitute material provided with a coating of said particular agent, and to a kit for use in a method of installing a bone substitute material comprising a bone substitute material as well as citrate, citric acid, monobasic sodium phosphate, dextrose, and adenine. | 2015-08-13 |
20150224225 | ANTIMICROBIAL COATING COMPOSITIONS - The invention relates to an antimicrobial coating composition for coating articles comprising: an antimicrobial peptide and a nanoparticle bound to said antimicrobial peptide, wherein the composition is suitable to be bonded to the surface of the article. The composition can comprise a coating composition of medical devices and laboratory surfaces. | 2015-08-13 |
20150224226 | METHODS OF TISSUE GENERATION - Provided herein are methods of generating tissues and organs in vitro or ex vivo comprising depositing cells and extracellular matrix onto a surface, as well as methods of using such tissues and organs. In one embodiment, the cells and ECM used in accordance with the methods for generating tissues (e.g., three-dimensional tissues) and organs described herein are deposited as part of the same composition. In another embodiment, the cells and ECM used in accordance with the methods for generating tissues (e.g., three-dimensional tissues) and organs described herein are deposited as part of different compositions. | 2015-08-13 |
20150224227 | Bone Grafts and Methods of Making and Using Bone Grafts - Provided herein are bone grafts and methods of making and using the same, as well as products and kits that include such bone grafts. In particular, bone grafts are provided that include osteogenic stem cells in a mix of osteoinductive demineralized bone matrix and osteoconductive cortico-cancellous chips. | 2015-08-13 |
20150224228 | MULTI-COMPONENT JOINING OF PLASTIC PREPARATIONS IN ORDER TO PRODUCE MEDICAL DEVICES WITH FUNCTIONAL SURFACES - A process for producing medical devices with functional surfaces, e.g., ceramic implants having bone-affine surfaces, and to medical devices produced in such a manner. | 2015-08-13 |
20150224229 | LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS - A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating. | 2015-08-13 |
20150224230 | Textile Product - Improvements applied to a textile product, and more particularly wherein the improved product is a woven textile product-fabric containing bioceramic microparticles embedded into the fibers thereof with high capacity of irradiation in the infrared region, provided to be used both in humans and animals, more particularly the invention is related to a textile product containing bioceramic microparticles with high capacity of infrared irradiation which, in contact with the heat of the human body, is capable of transmitting infrared radiation in the range between 3 μm and 14.8 μm, preferentially in the 14.8 micron range, said infrared radiation at this wavelength being capable of regulating the blood microcirculation, as the result of its high protection, the blood microcirculation being the nervous center of human and/or animal metabolism | 2015-08-13 |
20150224231 | COHERENT SINGLE LAYER HIGH STRENGTH SYNTHETIC POLYMER COMPOSITES FOR PROSTHETIC VALVES - Thin, biocompatible, high-strength, composite materials are disclosed that are suitable for use in a prosthetic valve for regulating blood flow direction. In one aspect, the leaflet material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as a prosthetic heart valve leaflet. The leaflet material includes a coherent single layer and an elastomer, wherein the elastomer is present in the pores of the porous coherent single layer. | 2015-08-13 |
20150224232 | MEDICAL MATERIAL FOR LONG-TERM IN VIVO IMPLANTATION USE WHICH IS MADE FROM ULTRAFINE FIBER - A medical material for in vivo implantation use, characterized in that a polyethylene terephthalate ultrafine fiber is provided in at least a part of the medical material, wherein the polyethylene terephthalate ultrafine fiber is produced by spinning a polyethylene terephthalate chip, which is produced using germanium or titanium oxide as a catalyst, by a direct spinning method and then stretching the spun product and has a single fiber fineness of 0.8 dtex or less. | 2015-08-13 |
20150224233 | CROSS-LINKED FATTY ACID-BASED BIOMATERIALS - Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided. | 2015-08-13 |
20150224234 | MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING OILS, FATTY ACIDS AND/OR LIPIDS - The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. In further embodiments, the chemical compound is water-soluble. | 2015-08-13 |
20150224235 | IN SITU FORMING HEMOSTATIC FOAM IMPLANTS - Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.). | 2015-08-13 |
20150224236 | COMPOSITIONS AND METHODS FOR DELIVERING AN AGENT TO A WOUND - The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting). | 2015-08-13 |
20150224237 | MOBILE INSTRUMENT ASSEMBLY FOR USE AS PART OF A MEDICAL/SURGICAL WASTE COLLECTION SYSTEM, THE ASSEMBLY INCLUDING A VACUUM SOURCE TO WHICH A MOBILE WASTE COLLECTION CART CAN BE RELEASABLY ATTACHED - A waste collection system for collecting waste during medical/surgical procedures including a mobile container cart with a waste container. A container cart is selectively coupled to a suction cart that includes a vacuum pump. The connection of the carts results in the connection of the vacuum pump to the waste container. The vacuum pump draws a vacuum that results in waste being drawn through a suction line into the waste container. The container cart holds instruments that can be removably attached to the container cart. This facilitates the configuration of the container cart for the specific procedure for which it is necessary to draw a suction. | 2015-08-13 |
20150224238 | WOUND DRESSING - A method and apparatus are disclosed for dressing a wound. The apparatus comprises a sealing layer comprising at least one orifice, an absorbent layer over the sealing layer, absorbing wound exude and a liquid impermeable, gas permeable filter layer over the absorbent layer. | 2015-08-13 |
20150224239 | SYSTEMS AND METHODS FOR DELIVERING FLUID TO A WOUND THERAPY DRESSING - Provided are systems and methods for delivery of fluid to a wound therapy dressing. In exemplary embodiments, a pressure source provides negative pressure to a wound dressing and a biasing mechanism provides positive pressure to a fluid reservoir. | 2015-08-13 |
20150224240 | TRANSSEPTAL CANNULA, TIP, DELIVERY SYSTEM, AND METHOD - A cannula assembly, further comprising a cannula body for directing blood from the heart of a patient, having distal and proximal ends and a lumen therebetween. A tip coupled to the distal end of the body, the tip having an opening. A pump for drawing blood into the cannula assembly and dispensing the blood from the cannula assembly and into the patient circulatory system. The lumen of the cannula body further comprises a first inner diameter at the proximal end and a second inner diameter at the distal end, the first inner diameter being larger than the second inner diameter. A tapered portion defined as a decrease in inner diameter from the first inner diameter to the second inner diameter between the proximal and distal ends, the tapered portion configured to prevent cavitation of the blood within the cannula. | 2015-08-13 |
20150224241 | APPARATUS AND A METHOD FOR EXTRACORPOREAL BLOOD TREATMENT - An apparatus for extracorporeal blood treatment comprises a sensor ( | 2015-08-13 |
20150224242 | BLOOD CIRCUIT ASSEMBLY FOR A HEMODIALYSIS SYSTEM - A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient. | 2015-08-13 |
20150224243 | OPTIMIZING PERITONEAL DIALYSIS USING A PATIENT HAND-HELD SCANNING DEVICE - A handheld personal communication apparatus for dialysis includes: a reader to (i) read a marking displayed on a dialysis fluid container to acquire data concerning at least one of a dialysis fluid type or a dialysis fluid volume from the marking, and/or (ii) receive a patient weight signal from a weight scale; a processor using at least one of the dialysis fluid type, dialysis fluid volume, or patient weight to determine a dialysis dwell time for at least one cycle of a dialysis therapy, the dialysis dwell time being a time to achieve, over the at least one cycle, at least one of (a) a specified ultrafiltrate level, (b) a urea removal level, or (c) a creatinine removal level; and an output interface providing an indication to the patient of a completion of the dialysis dwell time. | 2015-08-13 |
20150224244 | POLYMERS FOR REVERSING HEPARIN-BASED ANTICOAGULATION - Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules. | 2015-08-13 |
20150224245 | SINGLE COLLECTION BAG BLOOD COLLECTION SYSTEM, METHOD AND APPARATUS - A blood or blood component collection and processing system, apparatus and method are disclosed. One embodiment includes a vascular access device and a blood collection container having a blood inlet and first and second blood component outlets. The outlets are located at opposite ends of the container, and a blood flow conduit extends between the vascular access device and collection container. The collection container is free of attachment to other blood collection containers when in an initial collection configuration at the time of collection. | 2015-08-13 |
20150224246 | NASAL IRRIGATION ASSEMBLY AND SYSTEM - An assembly for the handheld irrigation of a user's nasal cavity comprising a housing with a refill chamber containing irrigating fluid, an applicator, an actuator for forcing irrigating fluid from the refill chamber through the applicator into the user's nasal cavity during operation, and a solution port for refilling the refill chamber. Some embodiments of the present invention may further comprise a system for nasal irrigation that includes the assembly for nasal irrigation or handheld irrigator, as well as a solution assembly structured for dispensing irrigating fluid to the handheld irrigator, and a docking station for removably housing the handheld irrigator and solution assembly. | 2015-08-13 |
20150224247 | PACKAGING SYSTEM FOR ANALYTE SENSORS - A system and method are provided for packaging and sterilizing analyte sensors. The packaging system provides a structure for securing the analyte sensors in a fixed position and fixed orientation within the package. | 2015-08-13 |
20150224248 | ASSEMBLY FOR INJECTING A VISCOUS LIQUID PRODUCT - The present invention relates to an assembly for medical use comprising:
| 2015-08-13 |
20150224249 | TISSUE ENUCLEATION DEVICES AND RELATED METHODS - A method for treating BPH may include marking a target tissue portion of a prostate of a patient with a contrasting agent. The method may further include emitting energy from an energy emitting device toward the target tissue portion. Further, the method may include enucleating the target tissue portion. | 2015-08-13 |
20150224250 | CHEMICAL LIQUID INJECTION SYSTEM - An RFID chip including various types of data is mounted on a liquid syringe. A chemical liquid injector obtains various types of data from the RFID chip to perform a predetermined operation in accordance with at least some of the various types of data. For, example, a variable pattern for liquid can be recorded on the RFID chip of the liquid syringe to allow the chemical liquid injector to inject the liquid in accordance with the predetermined variable pattern. Thus, a large amount of data can be easily input into the chemical liquid injector to perform the various operations. | 2015-08-13 |
20150224251 | COMBINATION THERAPY INCLUDING PERIPHERAL NERVE FIELD STIMULATION - Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies. | 2015-08-13 |
20150224252 | Adjustment of Infusion User Interface Upon Docking Event - A patient care system includes a control unit capable of coupling with multiple modular medical devices. A modular medical device can be coupled with the control unit, wherein the behavior of the modular medical device automatically adjusts based on the status of being coupled or un-coupled with the control unit. | 2015-08-13 |
20150224253 | MOTION ACTIVATED SEPTUM PUNCTURING DRUG DELIVERY DEVICE - A method and apparatus are disclosed for delivery of a drug to a recipient. In some embodiments, the delivery apparatus may unseal a drug containing reservoir. In some embodiments, the delivery rate may be controlled and/or adjustable. Optionally the apparatus may be disposable. Optionally, the apparatus may have a low profile and/or be wearable and/or attachable to the recipient. Optionally, discharge of the drug and/or unsealing of the reservoir may be driven by a plunger moving parallel to the base of the apparatus. Optionally, the apparatus may release a hypodermic needle into the recipient. Optionally, release of the hypodermic needle may be in a direction non-parallel and/or orthogonal to the direction of movement of the plunger. Optionally, prior to release, the hypodermic needle may be preserved in an aseptic state by a needle opening septum sealing a needle opening. Optionally, upon release, the hypodermic needle may pierce the needle opening septum. | 2015-08-13 |
20150224254 | METHOD AND DEVICE FOR INSERTION OF TUBING INTO IRRIGATION AND INFUSION FLUID PUMPS - In one embodiment, a door is used to provide uniform pressure to insert tubing into slots of a pump having walls that are narrower than the outer diameter of the tubing. In another embodiment, connectors are attached to receptacles on the pump, where the connectors insert and/or hold the tubing in slots of the pump. The connectors push the tubing into the slots while closing thereby covering the slots, which helps assure that the tubing is properly inserted into the slots. Optionally, the tubing may be partially affixed to the connectors so that detaching the connectors from the pump receptacles may remove the tubing from the slots. In one embodiment, as long as the connectors are connected to the pump receptacles properly, the tubing is properly inserted and/or retained in the slots. | 2015-08-13 |
20150224255 | PATCH-SIZED FLUID DELIVERY SYSTEMS AND METHODS - A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device. | 2015-08-13 |
20150224256 | METHOD AND APPARATUS FOR AUTOMATICALLY ADJUSTING INJECTION RATE THROUGH FALLING - The present invention relates to an apparatus and a system for controlling an amount of medicine or fluid injection through falling due to potential energy of the fluid. For example, the present invention can automatically adjust an injection rate of a medicine injected into a patient by controlling an opening/closing degree of a medicine hose by using a driving element driven by electric power according to a comparison of the number of drops with a predetermined value. An apparatus for realizing the method includes an accommodating case for accommodating a connecting portion for connecting a fluid, a detection unit for detecting the number of drops, a control unit for comparing the information detected by the detection unit, and a driving element for opening and closing a passage of the medicine hose based on the contents analyzed by a control unit. | 2015-08-13 |
20150224257 | DEFORMABLE VALVE MECHANISM FOR CONTROLLING FLUID DELIVERY - A valve for controlling delivery of fluid includes a valve seat comprising a fluid inlet, a fluid outlet and a conical well having an opening, a beveled surface and a bottom, and a valve membrane comprising a conical portion having a base and a tip. The conical portion is configured to fit within the conical well of the valve seat. The valve membrane is configured to fluidly connect the fluid inlet to the fluid outlet when the valve membrane is in an undeformed position and fluidly disconnect the fluid inlet from the fluid outlet when the valve membrane is in a radially deformed position. | 2015-08-13 |
20150224258 | Dispense Interface for an Ejection Device - The invention inter alia relates to a dispense interface for an ejection device comprises at least two inlets; at least one outlet; a body portion; and a cover film; wherein the body portion and the cover film are bonded together; wherein the body portion and the cover film are configured to form a fluid channel arrangement between surfaces of the body portion and the cover film facing each other when the body portion and the cover film are bonded together; and wherein the fluid channel arrangement is configured to provide fluid communication between the at least two inlets and the at least one outlet. | 2015-08-13 |
20150224259 | Medicament Delivery Device - Provided is a medicament delivery device ( | 2015-08-13 |
20150224260 | Delivery system for injections throughout zone of body - A dispensing device which disperses medicate through a needle across a zone within a body. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a reservoir in fluid communication with the needle, positioned within the housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with the reservoir-connecting conduit, and a linear drive attached to the needle or to the needle-receiving member. The fluid drive impel fluids from the second reservoir to the reservoir-connecting conduit and thus drives the therapeutic agent from the reservoir during the linear displacement of the needle towards the housing. Fluid communication from the therapeutic agent reservoir to the needle is maintained by the tubing during operation of the linear drive. | 2015-08-13 |
20150224261 | CLOSURE CONTAINER FOR SINGLE DOSE DISPOSABLE PHARMACEUTICAL DELIVERY SYSTEM - Provided herein is a single dose disposable pharmaceutical delivery apparatus and methods of use and manufacture thereof. One aspect provides a single dose disposable pharmaceutical delivery apparatus that includes a needle hub seal attached to a needle hub and a bladder that can contain a pharmaceutical composition. Another aspect provides for dispensing a pharmaceutical composition from the delivery apparatus by rupturing the needle hub seal and fluidically connecting the needle and the bladder. Another aspect provides manufacturing the delivery apparatus according to steps including attaching a needle hub and a needle hub seal and combining the bladder and the needle hub, thereby forming an apparatus described herein. | 2015-08-13 |
20150224262 | Medical Device with Impact Resistant Housing - The present invention relates to a housing of a medical device and to a respective medical device, wherein the housing comprises a body to receive at least one device component and wherein the body is flexibly deformable in response to mechanical impact above a predefined threshold. | 2015-08-13 |
20150224263 | Device For Injecting A Pharmaceutical Liquid, Configured To Be Pre-filled - An injection device which is configured to be pre-filled, including a vessel for storing the liquid, having two opposing ends, each provided with an opening, referred to as proximal end and distal end, and arranged to receive a sliding piston in order to exert pressure on the liquid. The vessel includes a wall including at least two vertically adjacent layers, each including vertically adjacent plastic material, the first and second layers having different gas permeability. | 2015-08-13 |
20150224264 | SYRINGE CONTAINING A COMPOSITION, ESPECIALLY A PHARMACEUTICAL COMPOSITION, COMPRISING IMMUNOGLOBINS, METHOD FOR THE PRODUCTION THEREOF AND USE OF SAME - A syringe containing a composition, in particular pharmaceutical, including immunoglobulins, its manufacturing method and its use. | 2015-08-13 |
20150224265 | DRUG DELIVERY DEVICE AND METHOD FOR DETECTING A CONTACT - The present invention is directed to a drug delivery device with a drive mechanism including a piston rod with a bearing for driving a bung in a cartridge in a distal direction. A movable element is disposed displacably in an axial direction within the drive mechanism. The moveable element is movable between a first position in which a distal end of said movable element protrudes from said bearing and a second position in which a distal end of said movable element lies flush with the distal end of said bearing. The invention is further directed to a method for detecting the contact between the bearing and the movable bung. | 2015-08-13 |
20150224266 | DRUG DELIVERY DEVICE - The invention relates to a reusable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a cartridge holder for retaining a cartridge containing the medicament, a piston rod displaceable relative to the cartridge holder, a driver coupled to the piston rod, a display member for indicating a set dose and being coupled to the housing and to the driver, and a button coupled to the display member and to the driver. | 2015-08-13 |
20150224267 | SAFETY NEEDLE SYSTEM OPERABLE WITH A MEDICAL DEVICE - A safety needle system operable with a medical device includes: a housing with a needle mount having a needle; and a sheath telescopically engaged with the housing and surrounding the needle such that the sheath operates in a retracted position, in which the sheath exposes the needle, and an extended position, in which the sheath surrounds the needle. The sheath is coupleable to the medical device such that removal of the needle from the medical device draws the sheath over the needle, transitioning the sheath from the retracted position to the extended position. In one embodiment, the system includes a slider engaged with the sheath and/or housing and including a restraint that engages and disengages the sheath to respectively reinforce and weaken the coupling of the sheath and medical device. In another embodiment, the sheath includes a longitudinal track that slidingly engages a setting of the housing between sheath positions. | 2015-08-13 |
20150224268 | Charging Accessory Device for an Aerosol Delivery Device and Related System, Method, Apparatus, and Computer Program Product for Providing Interactive Services for Aerosol Delivery Devices - The present disclosure relates to charging accessory device for the aerosol delivery device and related systems, methods, apparatuses, and computer program products for providing interactive services for aerosol delivery devices. For example, a method may include a computing device establishing communication with a charging accessory device for an aerosol delivery device; receiving usage data for the aerosol delivery device provided by the charging accessory device; generating social data based on the usage data; and sending the social data to a social networking service including a community of aerosol delivery device users. | 2015-08-13 |
20150224269 | PRESSURE INDICATOR FOR AN OSCILLATING POSITIVE EXPIRATORY PRESSURE DEVICE - A pressure indicator for a respiratory treatment device, the pressure indicator including an instrument for measuring pressures, a conduit configured to transmit a pressure within the respiratory treatment device to the instrument, and a pressure stabilizer orifice positioned within the conduit. | 2015-08-13 |
20150224270 | RESISTANCE BREATHING DEVICE - A resistance breathing device having a pair of coaxially aligned cup members, which collectively define an inner chamber and an outer annular chamber surrounding the inner chamber. The inner cup member includes an end wall submerged within water located within the outer cup member, wherein the end wall includes a plurality of openings therein. A lid extends over the cup members and defines a plurality of openings in communication with the annular chamber. A mouthpiece is coupled to the lid and allows a user to breathe in and out through the device for resistance breathing training. | 2015-08-13 |
20150224271 | MATERIAL RECOVERY AND CAPTURE DEVICE FOR ATOMIZED MATERIAL DELIVERY APPARATUSES - A recovery and collection assembly for an atomized material inhalation device is provided. The recovery and collection assembly includes an outer tubular housing and an input tube. The outer tubular housing includes a sidewall defining an outer chamber, an upper end piece attached to an upper end of the sidewall, and a lower end piece attached to a lower end of the sidewall. The lower end piece has at least one air flow opening allowing fluid communication between an interior of the outer chamber and an atmosphere surrounding the outer tubular housing. The input tube extends through the lower end piece and has a first end in fluid communication with the atomized material inhalation device. The input tube also has a second end disposed in an upper half of the outer chamber and in fluid communication with the outer chamber and defines an inner chamber. | 2015-08-13 |
20150224272 | VENTILATOR-INITIATED PROMPT REGARDING HIGH-DELIVERED TIDAL VOLUME - This disclosure describes systems and methods for monitoring and evaluating ventilatory data to provide useful notifications and/or recommendations. Indeed, many clinicians may not easily identify or recognize data patterns and correlations indicative of certain patient conditions or the effectiveness of ventilatory treatment. Further, clinicians may not readily determine appropriate adjustments that may address certain patient conditions or the effectiveness of ventilatory treatment. Specifically, clinicians may not readily detect or recognize the occurrence of high-delivered V | 2015-08-13 |
20150224273 | SYSTEM AND METHOD FOR FACILITATING AN INTUBATION - A device for use with an endotracheal tube. The device includes a shaft having a wall with a flexible region proximate a tip of the shaft. The shaft both distally and proximally of the flexible region is of a higher durometer than the durometer of the flexible region. | 2015-08-13 |
20150224274 | DEFORMABLE INSERT FOR LOW PRESSURE PATIENT INTERFACE - A patient interface includes a frame, an inflatable seal, and a deformable insert. The frame includes an outer portion, an inner portion, and an opening extending therebetween. The inflatable seal is secured to the inner portion of the frame. The inflatable seal defines an internal volume and has at least one aperture. The deformable insert includes an outer surface, an inner surface and a passageway extending therebetween. The deformable insert is positioned within the internal volume of the seal and aligned with at least a portion of the frame inner portion. The passageway is aligned with the frame opening to define a gas flow path from the frame outer portion to the at least one aperture of the seal. | 2015-08-13 |
20150224275 | CUSTOMISATION OR ADJUSTMENT OF PATIENT INTERFACES - A sensor device in the form of a patient interface has a sensor arrangement for determining a degree of fitting of a contact surface to the patient. This enables design parameters for a customised patient interface to be determined or else fitting adjustments to be made, based on how well the customisation sensor device fits the patient. | 2015-08-13 |
20150224276 | CUSHION FOR MASK SYSTEM - A mouth cushion for a mask system includes a side wall, a membrane extending from the side wall and adapted to form a continuous seal around an exterior of a patient's mouth in use, and at least one support strut or rib provided to the side wall. The at least one support strut or rib is at least partially determinative of a deflection characteristic of the mouth cushion. | 2015-08-13 |
20150224277 | GAS IDENTIFICATION SYSTEM AND VOLUMETRICALLY CORRECTED GAS DELIVERY SYSTEM - A gas delivery system, having a gas identification, by which a gas supplied to the gas delivery system is identified, a blender, blending oxygen and the gas to provide a gas mixture with an oxygen flow rate set up by an operator, and at least one flow sensor, to measure a flow rate of the gas mixture. The blender is driven by an actuator motor to various blender positions with the blender positions being calibrated based on the specific heat ratio and the gas constant of the gas. The flow sensor can be installed at the inspiratory circuit, the proximal circuit and the expiratory circuit of the gas delivery system. The flow sensor output is corrected based on the actual conditions, including the temperature, pressure and humidity, and characteristics of the gas mixture. | 2015-08-13 |
20150224278 | NEBULIZED VENTILATION SYSTEM - A nebulizer is connected to an inspiratory air line of a ventilator and forms an air path along a longitudinal axis through which air is delivered to a patient from a ventilator. A nebulizer nozzle is carried within the nebulizer housing and aligned with the longitudinal axis through which gas is mixed with medication and discharged into the air path. A suction line extends from the discharge end of the nebulizer nozzle through the outer surface of the nebulizer housing to a medication receiver that draws medication upward from a medication container contained within the medication receiver and mixes the medication with gas passing through the nebulizer nozzle and nebulizes the medication for discharge into the air path to a patient. | 2015-08-13 |
20150224279 | Medical Aerosol Device - A medical aerosol device comprising a jet nebulizer within an aerosol chamber, a heating unit, and a liquid source. The jet nebulizer comprises a jet nozzle and an orifice in fluid communication with the liquid source, and functions by passing a jet of oxygen across the face of the orifice to draw liquid from the fluid source and through the orifice, where it is finely dispersed into an aerosol by the jet stream. The orifice includes an impinged portion curved to direct additional airflow across the orifice face, which is also canted away from the jet stream, which together results in a stronger and more consistent suction force on the liquid, and an aerosol in which at least 80% of the individual droplets are five microns or less. An improved heating control system and composition of a heating platen is also contemplated, as well as a method of use. | 2015-08-13 |
20150224280 | Stretch Valve Balloon Catheter and Methods for Producing and Using Same - A safety balloon catheter includes a flexible, multi-lumen balloon catheter having a hollow stretch valve. The catheter has a balloon, a hollow inflation lumen extending to the balloon interior and conveying inflation fluid to and from the balloon interior, a hollow second lumen, and a balloon drainage port fluidically connecting the balloon interior to the second lumen. The valve has distal and proximal portions, is shaped to permit a fluid to pass therethrough, and is positioned in the second lumen such that, in a steady state, the valve prevents the inflation fluid from passing through the drainage port, and, in a catheter-stretched state, the distal portion slides within the second lumen permitting inflation fluid to pass through the drainage port and into the second lumen and the second lumen wall at the proximal portion holds the proximal portion steady within the second lumen as the distal portion slides therein. | 2015-08-13 |
20150224281 | DEVICE AND METHODS FOR TARGETED TISSUE DRUG DELIVERY - Representative embodiments of the present invention provide for novel, minimally invasive implantable devices and methods for targeted tissue drug delivery of cardiovascular drugs. | 2015-08-13 |
20150224282 | SHEATH OR CATHETER FOR MEDICAL INTRODUCER ASSEMBLY - An introducer assembly provided with a sheath formed of a plurality of elongate sections which are coupled to one another along their longitudinal sides by a dovetail coupling. The sheath sections are slidable longitudinally relative to one another, enabling the sheath to be retracted in stages. This reduces the amount of friction which must be overcome in the use of the sheath and in particular during the deployment of a medical device carried within the sheath. The structure can also substantially increase the precision of deployment of the medical device, as well as decreasing the force required during the deployment operation. | 2015-08-13 |
20150224283 | Secondary Intravenous Line Kit and Method - A method for administering a primary intravenous fluid from a first sterile fluid container and a second intravenous fluid from a second sterile fluid container, which method requires using only one catheter tube, thus reducing both the equipment and the labor required to use dual intravenous solutions. | 2015-08-13 |
20150224284 | FLUID EXCHANGE CATHETER AND PROCESS FOR UNBLOCKING A FLUID EXCHANGE CATHETER - According to the invention, a fluid exchange catheter is provided, which catheter has a proximal end and a distal end, and comprises an obligatory lumen having a proximal end and a distal end, the distal end of the obligatory lumen having a closed shape, wherein a lumen wall of the obligatory lumen forms a distal wall portion at the distal end of the obligatory lumen, the distal wall portion comprising at least one lumen opening in the lumen wall. Furthermore, the catheter comprises at least one additional lumen having a proximal end and a distal end, the distal end being arranged inside the obligatory lumen remote from the distal end of the obligatory lumen such that fluid exiting the at least one additional lumen flows inside the distal end of the obligatory lumen. Here, the distal wall portion exhibits expansibility in at least an area surrounding the at least one lumen opening in order to provide an unblocking function for removing blockage of the catheter, any lumen can be adapted for fluid infusion and/or fluid aspiration, and an unblocking of the catheter is effected by altering the width of the at least one lumen opening by changing the infusion and/or aspiration fluid pressure of the catheter, the infusion and/or aspiration fluid pressure being different from an outer pressure acting on the outside of the distal wall portion of the obligatory lumen. | 2015-08-13 |
20150224285 | Medical Article Securement Systems - A medical article, such as a catheter, is secured with respect to a patient with a securement device. The securement device may include a retainer and anchor pad. Certain devices may further include, for example, straps, flaps, dressings, slots, and recesses for securing the medical article to the patient. The retainer may include a recess and/or a channel. At least one surface of the retainer may be coated with an adhesive. | 2015-08-13 |
20150224286 | CATHETER DEVICES WITH SECURING MECHANISMS AND RELATED METHODS - Catheter securement devices are generally described for securing the catheter hub to the access site following successful catheterization. Examples of catheter assemblies with integrated securing mechanisms and related methods are disclosed. The integrated device provides convenience and easy to use access to securing devices that are integrated to the wings of the catheter assemblies. | 2015-08-13 |
20150224287 | Central Venous Catheter Kit - A central venous catheter kit comprises a medical instrument and a catheter for use during catheterization. The medical instrument includes a syringe having a barrel and a plunger. A needle extends axially from the syringe. The needle has a lumen which is in fluid communication with the barrel of the syringe. There is a dilator disposed about the needle and a guidewire substantially disposed within the syringe. There is a guide for advancing the guidewire out of the syringe through the lumen of the needle. The catheter has a lumen and there is a guidewire disposed within the lumen of the catheter. The guidewire substantially disposed within the syringe and the guidewire disposed within the lumen of the catheter are each provided with a connector to allow the guidewires to be coupled. | 2015-08-13 |
20150224288 | METHODS, COMPOSITIONS AND APPARATUS FOR DELIVERING HETEROLOGOUS MOLECULES TO CELLS - A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex. | 2015-08-13 |
20150224289 | Treatment of Renal Hypertension or Carotid Sinus Syndrome with Adventitial Pharmaceutical Sympathetic Denervation or Neuromodulation - Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict medication regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient. | 2015-08-13 |