33rd week of 2015 patent applcation highlights part 24 |
Patent application number | Title | Published |
20150225691 | METHOD OF MAKING AGGLOMERATED MICROBIOLOGICAL MEDIA AND COMPOSITIONS THEREOF - A method of making a flowable, agglomerated nutrient medium is provided. The method comprises forming a nutrient medium composition by placing a powdered nutrient into a fluidized bed-type agglomeration chamber, flowing a fluidizing gas through the chamber, and contacting in the agglomeration chamber the powdered nutrient with an aerosol spray of an agglomeration liquid; and collecting the composition from the chamber. The nutrient component facilitates the growth of a microorganism. The composition formed by the method comprises a population of agglomerated nutrient medium particles and, optionally, nonagglomerated powdered nutrient. The population comprises at least about 30 weight percent agglomerated nutrient particles having an effective particle diameter of about 250-400 microns. Compositions, thin film culture devices, and kits comprising the flowable, dried agglomerated nutrient medium are also provided. | 2015-08-13 |
20150225692 | PROGRAMMABLE DRUG DELIVERY PROFILES OF TUMOR-TARGETED BACTERIA - The present invention relates to composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence that encodes therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences. | 2015-08-13 |
20150225693 | SEPARATOR DEVICE, DEPOSITION DEVICE AND SYSTEM FOR HANDLING OF SOMATIC PLANT EMBRYOS - Methods and devices for separating fluid-suspended plant propagules and non-plant propagules based on differences in their fluid drag properties are disclosed. Deposition method and device for depositing plant propagules into a receiver comprising growth substrate by means of a fluid jet is disclosed. An automated system for processing plant propagules from a bioreactor to the growth substrate is also disclosed. | 2015-08-13 |
20150225694 | Use of G-CSF In In Vitro Embryo Culture - An in vitro culture medium for embryos consisting of IVF culture medium additionally containing G-CSF at a concentration of at least 0.5 ng/ml, preferably between 1.0 and 5.0 ng/ml, is described; a method for in vitro embryo culture, comprising the steps of incubating a plurality of embryos in an in vitro culture medium consisting of IVF culture medium additionally containing G-CSF at a concentration of at least 0.5 ng/ml and growing such embryos until the 8-cell stage is reached is also described. | 2015-08-13 |
20150225695 | METHOD OF OBTAINING CHICKEN EMBRYONIC STEM CELLS - The present invention concerns a method of culturing embryonic stem (ES) cells of avian, comprising the steps of: a) suspending ES cells originating from the blastoderm disk of fertilized un-incubated avian egg(s) in a basal culture medium supplemented with: insulin-like growth factor-1 (IGF-1) and ciliary neurotrophic factor (CNTF); and animal serum; and optionally, at least one growth factors selected in the group comprising interleukin 6 (II-6), interleukin 6 receptor (II-6R), stem cell factor (SCF), fibroblast growth factor (FGF), leukaemia inhibitory factor (LIF), interleukin 11 (II-11), oncostatin and cardiotrophin; b) seeding the suspension of ES cells obtained in step a) on a layer of feeder cells and further culturing the ES cells for at least between 2 to 10 passages; c) optionally removing at least one growth factors selected SCF, FGF, II-6, II-6R, LIF, oncostatin and cardiotrophin and II-11 from the culture medium; d) further culturing the ES cells in the medium of step c) on a layer of feeder cells. | 2015-08-13 |
20150225696 | Methods for Efficient Immortalization Of Normal Human Cells - Methods for inducing non-clonal immortalization of normal epithelial cells by directly targeting the two main senescence barriers encountered by cultured epithelial cells. In human mammary epithelial cells (HMEC), the stress-associated stasis barrier was bypassed and the replicative senescence barrier, a consequence of critically shortened telomeres, was bypassed in post-stasis HMEC. Early passage non-clonal immortalized lines exhibited normal karyotypes. Methods of efficient HMEC immortalization, in the absence of “passenger” genomic errors, should facilitate examination of telomerase regulation, immortalization during human carcinoma progression, and methods for screening for toxic and environmental effect on progression. | 2015-08-13 |
20150225697 | NATURAL KILLER CELLS AND USES THEREOF - Provided herein are methods of producing natural killer (NK) cells and NK progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of NK cells and NK progenitor cell populations using a three-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein to an individual having the cancer or viral infection. | 2015-08-13 |
20150225698 | In Vitro Pancreatic Differentiation of Pluripotent Mammalian Cells - This invention relates to the in vitro differentiation of pluripotent cells into pancreatic progenitors by i) culturing pluripotent cells in a definitive endoderm (DE) medium comprising a TGFp ligand, fibroblast growth factor (FGF), bone morphogenetic protein (BMP), a PI3K inhibitor and optionally a GSK3 β inhibitor to produce a population of definitive endoderm cells, ii) culturing the definitive endoderm cells in a first pancreatic medium comprising an activin antagonist; FGF; retinoic acid; and a BMP inhibitor to produce a population of dorsal foregut cells; iii) culturing the dorsal foregut cells in a second pancreatic medium comprising FGF, retinoic acid, a BMP inhibitor, and a hedgehog signalling inhibitor, and; iv) culturing the endoderm cells in a third pancreatic medium comprising FGF. The progenitor cells thus produced may be further differentiated into pancreatic endocrine cells. These methods may be useful, for example, in producing pancreatic cells for therapy or disease modelling. | 2015-08-13 |
20150225699 | ACTIVATION OF INNATE IMMUNITY FOR ENHANCED NUCLEAR REPROGRAMMING OF SOMATIC CELLS WITH mRNA - The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses in the somatic cell. Methods of activating innate immunity include activation of PKR, of toll-like receptors, e.g. TLR3, etc. In some embodiments the mRNA provides the activator of innate immunity. | 2015-08-13 |
20150225700 | ARTIFICIAL THREE-DIMENSIONAL MICROENVIRONMENT NICHE CULTURE AND METHODS OF USING THE SAME - The present invention provides three-dimensional microenvironment niches prepared from biomaterial compositions that supports growth and self renewal of stem cells. The invention also provides methods for inducing pluripotency in a somatic cell using chemical compounds, as well as methods for screening for compounds that can induce pluripotency in a somatic cell. | 2015-08-13 |
20150225701 | Novel Nylanderia Pubens Virus - At least one novel virus capable of infecting crazy ants ( | 2015-08-13 |
20150225702 | ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF - The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease. | 2015-08-13 |
20150225703 | NOVEL CYTOCHROME P450 POLYPEPTIDE WITH INCREASED ENZYME ACTIVITY - The present invention pertains to an isolated P450 enzyme comprising or consisting of an amino acid sequence at least 80% identical to SEQ ID NO: 1, wherein said sequence comprises a threonine at position corresponding to position 225 and/or an aspartic acid mutation at position corresponding to position 289. The invention also concerns an isolated nucleic acid comprising a sequence encoding said enzyme, a vector comprising said nucleic acid, and a host cell containing said nucleic acid or said vector. Methods for preparing said enzyme and methods for producing steroid hormone precursors using the enzyme or the host cells featured in the invention are also provided. | 2015-08-13 |
20150225704 | NEUROPROTECTIVE PEPTIDES THAT INHIBIT INTERACTION OF PALMITOYL ACYL TRANSFERASE ZINC-FINGER DHHC TYPE CONTAINING 17 (ZD17) AND C-JUN N-TERMINAL KINASE (JNK) - Isolated polypeptides are disclosed herein, the isolated polypeptides comprising at least 90% identity to any one of: SEQ ID NO:1; SEQ ID NO:2; or SEQ ID NO:3, wherein the isolated polypeptide inhibits an interaction between palmitoyl acyl transferase zinc-finger DHHC type containing 17 (z D17) and c-jun N-terminal kinase (JNK). The polypeptides may be conjugated to a delivery and targeting moiety, such as the cell-membrane transduction domain of the HIV-1 Tat protein. There are also provided methods for treating a disease associated with cytotoxicity or excitotoxicity. | 2015-08-13 |
20150225705 | EXPRESSION OF ENZYMES IN YEAST FOR LIGNOCELLULOSE DERIVED OLIGOMER CBP - The present invention provides a multi-component enzyme system that hydrolyzes hemicellulose oligomers from hardwood which can be expressed, for example, in yeast such as | 2015-08-13 |
20150225706 | ALTERATION AND MODULATION OF PROTEIN ACTIVITY BY VARYING POST-TRANSLATIONAL MODIFICATION - Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins. | 2015-08-13 |
20150225707 | ULTRAPURE HYPOALLERGENIC SOLUTIONS OF SACROSIDASE - One aspect provides an ultrapure, hypoallergenic sacrosidase. Another aspect provides a solution of sacrosidase in about 1:1 glycerol/water having an enzymatic activity of at least about 7500 IU/mL and a residual papain concentration that does not include an allergic reaction in a human patient when given a dose of about 2.0 mL/day. | 2015-08-13 |
20150225708 | ALPHA-AMYLASES - The present invention relates to alpha-amylases, nucleic acids encoding the alpha-amylases, methods of producing the alpha-amylases, and methods of using the alpha-amylases. | 2015-08-13 |
20150225709 | METHODS FOR THE MANUFACTURE OF PROTEOLYTICALLY PROCESSED POLYPEPTIDES - The present invention relates to a novel proteolytically active polypeptide and various uses of the polypeptide (and others) in screening and manufacturing methods. | 2015-08-13 |
20150225710 | Coagulation Factor IX Conjugates - The present invention relates to Factor IX polypeptides conjugated to heparosan (HEP) polymers, methods for the manufacture thereof and uses of such conjugates. The resultant conjugates may be used—for example—in the treatment or prevention of bleeding disorders such as haemophilia B. | 2015-08-13 |
20150225711 | Factor VII Conjugates - The present invention relates to the conjugation of Factor VII polypeptides with heparosan polymers. The resultant conjugates may be used to deliver Factor VII, for example in the treatment or prevention of bleeding disorder | 2015-08-13 |
20150225712 | METHOD FOR ISOLATING NUCLEIC ACIDS FROM A FORMALDEHYDE RELEASER STABILIZED SAMPLE - The present invention pertains to a method for isolation and purification of nucleic acids from a stabilized sample or portion or fraction thereof, wherein the sample stabilization involved the use of at least one formaldehyde releaser and wherein the isolation of the nucleic acids from the stabilized sample or portion or fraction thereof involves the use of at least one cationic detergent during lysis. | 2015-08-13 |
20150225713 | METHODS FOR NUCLEIC ACID CAPTURE - Solutions, reagents, and methods for nucleic acid purification. In certain aspects, cationic surfactant and, optionally, an anionic surfactant solutions are provided which can be used for phase separation and capture of nucleic acids, such as plasmid or genomic DNA, to a solid phase carrier, such as a mineral matrix. | 2015-08-13 |
20150225714 | KIT FOR NUCLEIC ACID EXTRACTION AND A NUCLEIC ACID EXTRACTOR - A nucleic acid extractor reducing the possibility of cross contamination and a gene analysis apparatus having a nucleic acid amplification function and a detection function are provided. The nucleic acid extractor has a kit for nucleic acid extraction using silica-coated magnetic beads under the presence of a chaotropic agent, and includes a magnet cover | 2015-08-13 |
20150225715 | 3' TARGETING OLIGONUCLEOTIDES FOR MODULATING RNA - Aspects of the invention relate to methods for increasing gene expression in a targeted manner. In some embodiments, methods and compositions are provided that are useful for posttranscriptionally altering protein and/or RNA levels in a targeted manner. Aspects of the invention disclosed herein provide methods and compositions that are useful for protecting RNAs from degradation (e.g., exonuclease mediated degradation). | 2015-08-13 |
20150225716 | MIRNA FOR TREATING HEAD AND NECK CANCER - The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change. | 2015-08-13 |
20150225717 | Selective Reactivation of Genes on the Inactive X Chromosome - Methods and compositions for selectively reactivating genes on the inactive X chromosome (Xi) in a locus-specific manner, e.g., genes associated with X-linked diseases, e.g., Rett Syndrome, Factor VIII or IX deficiency, Fragile X Syndrome, Duchenne muscular dystrophy, and PNH, in heterozygous females. | 2015-08-13 |
20150225718 | Antisense Polynucleotides to Induce Exon Skipping and Methods of Treating Dystrophies - Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as Limb-Girdle Muscular Dystrophy. One aspect the disclosure provides an isolated antisense polynucleotide wherein the polynucleotide specifically hybridizes to an exon target region of a gamma sarcoglycan RNA, wherein the exon is selected from the group consisting of exon 4 (SEQ ID NO:1), exon 5 (SEQ ID NO: 2), exon 6 (SEQ ID NO: 3), exon 7 (SEQ ID NO: 4) and a combination thereof. In some embodiments, the antisense polynucleotide cannot form an RNase H substrate, and in further embodiments the antisense polynucleotide comprises a modified polynucleotide backbone. | 2015-08-13 |
20150225719 | PHARMACEUTICAL COMPOSITION FOR TREATING LIVER DISEASES - The present invention relates to a pharmaceutical composition for treating liver diseases, comprising a miRNA mimic containing a single strand RNA molecule of hsa-miR-21-3p (SEQ ID No: 35). The miRNA mimic of the present invention can be used to treat liver diseases through regulating the expression of methionine adenosyltransferase 2A and 2B (MAT2A and MAT2B), acetyl-CoA carboxylase 1 and 2 (ACACA and ACACB), diglyceride acyltransferase 2 (DGAT2), and so on. In addition, the present invention also relates to a method for reducing the expression of the above-mentioned enzymes. | 2015-08-13 |
20150225720 | RNAi Inhibition of Serum Amyloid A For Treatment of Glaucoma - RNA interference is provided for inhibition of serum amyloid A mRNA expression in glaucomas involving SAA expression. | 2015-08-13 |
20150225721 | Methods and Compositions Using miR-3151 in the Diagnosis and Treatment of Cancer - Compositions comprising therapeutic oligonucleotide miR-3151 compounds that target the expression of genes associated with tumorigenesis or cell transformation are provided. | 2015-08-13 |
20150225722 | METHODS FOR SELECTIVE TARGETING OF HETEROCHROMATIN FORMING NON-CODING RNA - Provided herein are oligonucleotides that are useful for modulating the heterochromatin state of genes; related compositions and methods are also provided. In some embodiments, methods are provided for treating a disease associated with heterochromatin formation, including diseases associated with repeat expansion within genes. | 2015-08-13 |
20150225723 | Gene Nanocomposite, and Cellular Internalization Method of Gene Using Same - A gene nanocomposite and a cellular internalization method of a gene using the same are provided. More specifically provided is a gene nanocomposite including: a photosensitizer-conjugated polymer; and one or more materials selected from a gene and a gene/cationic polymer composite, and a cellular internalization method of a gene using the same to improve gene delivery efficiency into a mammal-derived cell and gene expression. | 2015-08-13 |
20150225724 | TREATMENT OF ADIPONECTIN (ADIPOQ) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO AN ADIPONECTIN (ADIPOQ) - The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Adiponectin (ADIPOQ), in particular, by targeting natural antisense polynucleotides of an Adiponectin (ADIPOQ). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Adiponectins (ADIPOQ)s. | 2015-08-13 |
20150225725 | TREATMENT OF FIBROBLAST GROWTH FACTOR 21 (FGF21) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO FGF21 - The present invention relates to antisense of oligonucleotides that modulate the expression of and/or function of Fibroblast growth factor 21 (FGF21), in particular, by targeting natural antisense polynucleotides of Fibroblast growth factor 21 (FGF21). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of FGF21. | 2015-08-13 |
20150225726 | MICROORGANISMS AND PROCESSES FOR THE CONVERSION OF GLYCEROL TO ISOPRENE - The present invention provides non-naturally occurring microorganisms that have been modified to produce isoprene from glycerol. The microorganisms include one of several glycerol dissimilation pathways and one of several isoprene production pathways. | 2015-08-13 |
20150225727 | LINEAR DONOR CONSTRUCTS FOR TARGETED INTEGRATION - Disclosed herein are linear donor molecules comprising homology arms of 50-750 base pairs (e.g., 50-100 base pairs) flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell. | 2015-08-13 |
20150225728 | CELL MODIFICATION METHOD USING ESSENTIAL GENES AS MARKERS AND OPTIONALLY RECYCLING THESE - The invention relates to a method for modification of a host cell at a target locus, which method comprises: providing a host cell comprising, at a first locus, at least two site-specific recombination sites and a nucleic acid having an essential function or encoding a product having an essential function; introducing into the host cell, at the target locus, a further nucleic acid having the essential function or encoding for a product having the essential function; and carrying out recombination at the first locus via the at least two site-specific recombination sites, so that the nucleic acid having an essential function or encoding a product having an essential function is rendered non-functional, thereby to modify the host cell at the target locus. The invention also relates to a cell obtainable by a method of the invention. | 2015-08-13 |
20150225729 | METHODS AND COMPOSITIONS FOR SYNTHESIS OF NUCLEIC ACID MOLECULES USING MULTIPLERECOGNITION SITES - The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. The invention also provides host cells comprising nucleic acid molecules of the invention or prepared according to the methods of the invention, and also provides kits comprising the compositions, host cells and nucleic acid molecules of the invention, which may be used to synthesize nucleic acid molecules according to the methods of the invention. | 2015-08-13 |
20150225730 | METHODS FOR GENERATING LIBRARIES WITH CO-VARYING REGIONS OF POLYNULEOTIDES FOR GENOME MODIFICATION - The invention provides methods for introducing co-varying paired nucleic acids into a vector such under separate transcriptional control. An oligonucleotide is synthesized including the paired nucleic acids. The oligonucleotide is then assembled with a spacer nucleic acid encoding a promoter. After assembly the spacer nucleic acid is to one side of the oligonucleotide encoding the paired segments. However, on circularization of the assembled nucleic acid and cleavage between the DNA segments the spacer oligonucleotide and its components now occur between the paired segments. The resulting nucleic acid can now be cloned into a vector with a single step, such that each of the paired nucleic acid segments is linked to its own promoter. The present method can readily be extended to library screening without proportionately increasing the effort. | 2015-08-13 |
20150225731 | INDUCIBLE COEXPRESSION SYSTEM - The present invention is an inducible coexpression system, capable of controlled induction of expression of each gene product. | 2015-08-13 |
20150225732 | E. COLI PLASMID DNA PRODUCTION - General methods and strains of bacteria are described that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin mediated plasmid extraction combined with flocculation mediated removal of cell debris and host nucleic acids achieves increased yield and purity with simplified downstream purification and reduced waste streams, thus reducing production costs. | 2015-08-13 |
20150225733 | YEAST CELL HAVING ENHANCED GENETIC MANIPULATION EFFICIENCY AND USE THEREOF - A recombinant yeast cell having enhanced genetic manipulation efficiency, a method of preparing the recombinant yeast cell, and a method of preparing a biochemical by using the same. | 2015-08-13 |
20150225734 | GENE TARGETING IN PLANTS USING DNA VIRUSES - Systems and methods for gene targeting in plants, including systems and methods that include the use of geminiviruses and customizable endonucleases. | 2015-08-13 |
20150225735 | STRONG CONSTITUTIVE PROMOTERS FOR HETEROLOGOUS EXPRESSION OF PROTEINS IN PLANTS - Nucleic acid promoters isolated from | 2015-08-13 |
20150225736 | SEQUENCES INVOLVED IN PLANT YIELD AND METHODS OF USING - Nucleic acid sequences involved in plant yield are provided, as are methods of using such nucleic acid sequences. | 2015-08-13 |
20150225737 | Drought-Tolerance in Plants - Drought-inducible plant promoters are described herein that are useful for expressing drought tolerance factors in plants. | 2015-08-13 |
20150225738 | TRANSGENIC PLANT OF THE SPECIES SOLANUM TUBEROSUM WITH RESISTANCE TO PHYTOPHTHORA - The present invention concerns a transgenic plant of the species | 2015-08-13 |
20150225739 | EXPRESSION VECTORS COMPRISING IRES ELEMENT AND THE MULTIPLE EXPRESSION GENE SYSTEM THEREOF - The present invention provides an expression vector comprising an internal ribosome entry site (IRES) element, comprising a sequence of SEQ ID NO: 1, wherein the sequence is an IRES element from a gene icp35 of White spot syndrome virus. The expression vector can be easily operated in insect cells or Crustacean cells and has excellent expression efficiency due to having such an IRES element. A multiple expression gene system is also provided herein, which comprises the expression vector. The system comprising the IRES element can be functioned via transfection, such that the experimental process can be considerably shortened, and thus studying costs will be reduced effectively. | 2015-08-13 |
20150225740 | IMPORTATION OF MITOCHODRIAL PROTEIN BY AN ENHANCED ALLOTOPIC APPROACH - An expression vector containing appropriate mitochondrion-targeting sequences (MTS) and appropriate 3′UTR sequences provides efficient and stable delivery of a mRNA encoding a protein (CDS) to the mitochondrion of a mammalian cell. The MTS and 3′UTR sequences guide the CDS mRNA from the nuclear compartment of the cell to mitochondrion-bound polysomes, where the CDS is translated. This provides an efficient translocation of a mature functional protein into the mitochondria. A method of targeting mRNA expressed in the nuclear compartment of a mammalian cell to the mitochondrion is also provided. The vector and methods can be used to treat defects in mitochondrial function. | 2015-08-13 |
20150225741 | VECTORS FOR DELIVERY OF LIGHT SENSITIVE PROTEINS AND METHODS OF USE - Provided herein are compositions and methods for gene and etiology-nonspecific and circuit-specific treatment of diseases, utilizing vectors for delivery of light-sensitive proteins to diseased and normal cells and tissues of interest. | 2015-08-13 |
20150225742 | Methods and System for Photo-activated Hydrogen Generation - Systems and methods for providing alternative fuel, in particular hydrogen photocatalytically generated by a system comprising photoactive nanoparticles and a nitrogenase cofactor are provided. In one aspect, the system includes a water soluble cadmium selenide nanoparticle (CdSe) surface capped with mercaptosuccinate (CdSe-MSA); and a NafY.FeMo-co complex comprising a NafY protein and an iron-molybdenum cofactor (FeMo-co); wherein the CdSe-MSA and the NafY.FeMo-co complex are present in about 1:1 molar ratio in a CdSe-MSA.NafY.FeMo-co system. In various embodiments, when illuminated, the CdSe-MSA.NafY.FeMo-co system is capable of photocatalytically producing hydrogen gas for an extended period of, e.g., at least 5 hours, at least 10 hours, or at least 90 hours. Methods for making and using the same are also provided. | 2015-08-13 |
20150225743 | BIOCATALYST FOR CONVERSION OF METHANE AND METHANOL TO ISOPRENE - Meythylotrophic cells and in particular methanotrophic bacterial cells are genetically engineered to produce isoprene from methane and/or methanol by expressing a heterologous isoprene synthase, and increasing activity of isopentenyl diphosphate isomerase. In addition, upstream DXP pathway enzymes may have increased activity, enzymes in pathways downstream of IPP and DMAPP may have decreased activity, and methane/methanol assimilation pathway enzymes may have increased activity. | 2015-08-13 |
20150225744 | UTILIZATION OF PHOSPHOKETOLASE IN THE PRODUCTION OF MEVALONATE, ISOPRENOID PRECURSORS, AND ISOPRENE - The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes. | 2015-08-13 |
20150225745 | GLUCOSE AND XYLOSE CO-UTILIZATION IN E. COLI - The present invention provides host cells having improved sugar utilization or co-utilization, methods of producing host cells having improved sugar utilization or co-utilization, and methods of using host cells having improved sugar utilization or co-utilization. The present invention provides | 2015-08-13 |
20150225746 | PROCESS FOR PRODUCING ALCOHOL BY FERMENTATION OF SUGARS - A process for increasing a production of alcohol by fermenting sugars may include applying a direct current electrical field to a fermentation broth, which occurs before the fermentation broth inoculates with a concentration of yeasts; and controlling a pH value of said fermentation broth to maintain the pH value with a specific range. | 2015-08-13 |
20150225747 | MUTANT YEAST STRAIN WITH DECREASED GLYCEROL PRODUCTION - The disclosure relates to the use of a mutant SSK1 gene encoding a truncated ssk1 protein for the construction of a mutant yeast strain with decreased glycerol production, when compared to the wild-type strain. It relates further to the use of such strains for high-yield bioethanol production, especially in high osmotic media, or on cellulosic hydrolysates, where normal yeast strains do produce a significant amount of glycerol. | 2015-08-13 |
20150225748 | PROCESSES FOR ANAEROBIC BIOCONVERSION OF HYDROGEN-CONTAINING GASES TO OXYGENATED ORGANIC COMPOUNDS - Anaerobic processes for the bioconversion of syngas to oxygenated organic compounds in an aqueous menstruum are disclosed where exogenous carbon dioxide is used to provide a syngas-containing substrate gas having a desired electron to carbon ratio. The exogenous carbon dioxide contains free oxygen, and the aqueous menstruum withdrawn for product recovery is contacted with the exogenous carbon dioxide to reduce its oxygen concentration before being supplied as part of the substrate gas. | 2015-08-13 |
20150225749 | HIGH MOISTURE, RENEWABLE FEEDSTOCK USE IN INTEGRATED ANAEROBIC TREATMENT AND SYNGAS FERMENTATION TO ALCOHOLS - The present invention relates to use of high moisture, renewable feedstocks in integrated anaerobic digestion treatment (AD) and Syngas fermentation to alcohols and other soluble products. More specifically, the invention relates to use of high moisture, renewable feedstocks such as the organic fraction of municipal solid waste (OFMSW), biological waste sludge, source separated organics, green wastes such as FW from supermarkets, cafeterias, etc., and other such plentiful sources for power and fermentation, significantly increasing yield of a desired alcohol. | 2015-08-13 |
20150225750 | Two-Stage Production of Higher Alcohols - Methods and systems for the production of alcohols are described. A two stage process is utilized, where fermentation in a first stage produces an intermediate product, such as an amino acid or organic acid, from a carbon containing feedstock. A second stage produces alcohol by fermentation of this intermediate product. | 2015-08-13 |
20150225751 | MICROBIAL PRODUCTION OF MUCONIC ACID AND SALICYLIC ACID - The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements. | 2015-08-13 |
20150225752 | ACID RESISTANT YEAST CELL AND USE THEREOF - having acid resistance at a pH of about 2.0 to about 5.0, a method of preparing the | 2015-08-13 |
20150225753 | HYDROXY- AND DICARBOXYLIC-FAT SYNTHSIS BY MICROBES - Systems, methods and microbes that allow the biological production of hydroxy fatty acids and dicarboxylic fatty acids are provided. Specifically, hydroxy fatty acids and dicarboxylic fatty acids are produced by microbes that have been engineered to overexpress acyl ACP thioesterase plus an alkane degration pathway, such as AlkBGT or AlkJH These can be in separate microbes or the same microbe, and separate microbes can be co-cultured or sequentially cultured. Continuously fed systems transferring secreted fats from one microbial culture to another can also be used. | 2015-08-13 |
20150225754 | Increased Production of Terpenes and Terpenoids - This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof. | 2015-08-13 |
20150225755 | Ergothioneine Production Through Metabolic Engineering - The present disclosure relates to the production of ergothioneine through either in vitro enzymatic transformations or fermentations using microbials created by metabolic engineering. Also disclosed are transformed cells useful in such methods and ergothioneine produced by such methods. Transformed cells of the disclosure are capable of converting histidine and cysteine or hercynine and cysteine into ergothioneine in greater efficiency than the untransformed wild-type cells. | 2015-08-13 |
20150225756 | ALCOHOL SULFITE BIOREFINERY PROCESS - A biorefinery process to fractionate lignocellulosic materials into cellulose, hemicelluloses and lignin using a pretreatment with mixture of alcohol, sulfur dioxide and water. Further treatment with enzymes, micro-organisms, and optionally bisulfite ion, are used to convert intermediate products to alcohol and lignin derivatives. | 2015-08-13 |
20150225757 | PROCESS FOR INCREASING YIELD OF DEXTROSE PRODUCTION PROCESS, BY MEMBRANE TECHNOLOGY - The invention relates to a process for increasing the dextrose recovery from a dextrose containing solution. In particular, the invention relates to a process for increasing the dextrose yield of a starch hydrolysis process. The process comprises membrane filtration of a dextrose containing solution and an enzyme treatment of the retentate of the filtration. | 2015-08-13 |
20150225758 | GENETICALLY MODIFIED CELLS AND METHODS FOR MAKING ACTIVATED SUGAR-NUCLEOTIDES - This disclosure generally relates to genetically engineered cells and methods of making and using such genetically engineered cells. Generally, the genetically engineered cells exhibit an increase in synthesis of an activated sugar-nucleotide compared to a wild type control. In some embodiments, the activated sugar-nucleotide produced by the genetically engineered cell is an activated sugar-nucleotide that is not natively synthesized by wild type, un-engineered cell. In some embodiments, the activated sugar-nucleotide is an activated uridine diphosphate sugar nucleotide. In other embodiments, the activated sugar-nucleotide is an activated cysteine monophosphate sugar nucleotide. In still other embodiments, the activated sugar-nucleotide is an activated guanosine diphosphate sugar nucleotide. In some embodiments, the activated sugar-nucleotide includes an isotopic label. | 2015-08-13 |
20150225759 | SOPHOROLIPIDS AS PROTEIN INDUCERS AND INHIBITORS IN FERMENTATION MEDIUM - A method for producing sophorolipids having protein inducer and/or repressor activities having the steps of synthesizing the sophorolipid by fermentation of | 2015-08-13 |
20150225760 | HARVEST OPERATIONS FOR RECOMBINANT PROTEINS - The present invention contemplates methods of producing a recombinant protein comprising fermenting a prokaryotic host cell wherein said prokaryotic host cell has been transformed with a nucleic acid encoding said recombinant protein, harvesting said recombinant protein under conditions where dO | 2015-08-13 |
20150225761 | Methods for Producing Polypeptides in Protease-Deficient Mutants of Trichoderma - The present invention relates to mutants of a parent | 2015-08-13 |
20150225762 | SAME-DAY BLOOD CULTURE WITH DIGITAL MICROSCOPY - Generally provided are methods for rapid culture of microorganisms in a sample, including methods for growth and recovery of live microbial cells directly from a sample. Various features include enabling growth of microorganisms in a sample along with a reduction of sample debris that may interfere with microorganism detection, and reduction in toxicities that may inhibit microorganism growth. Further methods for selectively degrading non-viable microbial cells, are provided, for enhanced detection of viable microbial cells following a growth period. | 2015-08-13 |
20150225763 | BIOMARKER - A method for determining the malarial status of a subject, comprising the steps of: providing a biological sample obtained from a subject; and determining the level, or presence, of PF10_0121 (hypoxanthine phosphoribosyltransferase, pHPRT) and/or PF11_0208 (phosphoglycerate mutase, pPGM) in the biological sample. | 2015-08-13 |
20150225764 | METHOD FOR SIMULTANEOUSLY MEASURING ACTIVITY OF VARIOUS ENZYMES BY USING MULTI-WAVELENGTH ABSORPTION SINGLE CHANNEL - A method for simultaneously measuring the activities of multiple kinds of enzymes in single channel through concimitantly monitoring multiple wavelength absorbances is claimed; based on linear additivity of absorbances and the isoabsorbance wavelengths of chromogenic substrates and their chromogenic products, both the principles for the combination of chromogenic substrates required for simultaneously measuring the activities of multiple kinds of enzymes in single channel through concimitantly monitoring multiple wavelength absorbances and an approach for data processing to eliminate the interference of the overlapped absorbances are developed, kinetic analysis of reaction curves via numerical integration eliminates the interference of all substrates and products and estimates the maximal reaction rates of the enzymes to be measured, giving the linear ranges and the limits of quantification for simultaneously measuring the activities of multiple kinds of enzymes in single channel comparable to those by separate assays; the present invention is applicable for simultaneously measuring the activities of multiple kinds of enzymes in biological samples, simultaneously measuring multiple components by enzyme-labeled immunoassays, screening simultaneously of inhibitors against multiple targets, for the practice in clinical biochemical analyses, clinical immunoassays, health laboratory analyses, the discovery of inhibitors, and the basical researches which need the present invention. | 2015-08-13 |
20150225765 | METHODS FOR DETERMINING ENZYMATIC ACTIVITY - Methods for determining thermophilic enzymatic activity include heating a substrate solution in a plurality of closed volumes to a predetermined reaction temperature. Without opening the closed volumes, at least one enzyme is added, substantially simultaneously, to the closed volumes. At the predetermined reaction temperature, the closed volumes are agitated and then the activity of the at least one enzyme is determined. The methods are conducive for characterizing enzymes of high-temperature reactions, with insoluble substrates, with substrates and enzymes that do not readily intermix, and with low volumes of substrate and enzyme. Systems for characterizing the enzymes are also disclosed. | 2015-08-13 |
20150225766 | CELL-PERMEABLE PROBES FOR IDENTIFICATION AND IMAGING OF SIALIDASES - Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions. | 2015-08-13 |
20150225767 | SYSTEM AND METHOD FOR DETECTING OF ALPHA-METHYLACYL-COA RACEMASE (AMACR) AND PROSTATE CANCER - A detection system for determining alpha-methylacyl-CoA (AMACR) levels in a bodily sample includes at least one reaction solution for generating H | 2015-08-13 |
20150225768 | QUANTIFICATION METHOD, QUANTIFICATION DEVICE, AND QUANTIFICATION KIT - A quantification method includes a calibration curve preparing step to measure a standard solution, which has been prepared by adding sodium ions so that a sodium ion content of the standard solution is equaled to a sodium ion content of a sample to be measured with a method employing a reaction that activates a limulus reagent and/or a biochemical luminescent reaction caused by ATP, luciferin, and luciferase, and to prepare a calibration curve that represents a relation between a measurement value and an amount of a component to be measured; a sample measuring step to measure the sample to be measured with a method being the same as that used in the calibration curve preparing step; and a quantifying step to find, by using the calibration curve, an amount of the component to be measured in the sample to be measured from a measurement value in the sample measuring step. | 2015-08-13 |
20150225769 | METHODS AND MATERIALS FOR ASSESSING RNA EXPRESSION - This document provides methods and materials for assessing RNA expression. For example, methods and materials for detecting the presence, absence, or amount of target nucleic acid (e.g., target RNA or target cDNA produced from target RNA), kits for detecting the presence, absence, or amount of target nucleic acid (e.g., target RNA or target cDNA produced from target RNA), and methods for making such kits are provided. | 2015-08-13 |
20150225770 | PHENOTYPE-NEUTRAL BARCODES FOR DIGITAL ANALYSIS - Processes of specifically and effectively labeling an organism are provided. Processes involve the incorporation of a plurality of phenotype neutral tags that are differentially detected where the presence or absence of the tag is represented by a digital readout. The incorporation of stealth tags or insertion tags provides a rapid and population maintaining labeling of an organism that can be readily identified by digital PCR techniques. | 2015-08-13 |
20150225771 | ANALYSIS CHIP AND ANALYSIS DEVICE - An analysis chip capable of introducing a sample into a capillary without failure and an analysis device using the analysis chip are provided. An analysis chip ( | 2015-08-13 |
20150225772 | Micro-Liquid Phase Reaction Method Based on Substrate with Hydrophilic-Hydrophobic Patterned Surface - A micro-liquid phase reaction method based on a substrate with a hydrophilic-hydrophobic patterned surface, including the following: applying a liquid phase system containing a hydrotropic substance and/or an amphipathic substance to a hydrophobic smooth plane in a sample-spotting manner to form an array of tiny droplets, subsequently removing the solvent in each droplet to bond the hydrotropic substance and/or amphipathic substance in each droplet to the hydrophobic smooth plane so as to form an array of hydrophilic bonding points, then moving an aqueous phase system or hydrophilic liquid phase system containing more than one reactants over the hydrophobic smooth plane, thereby forming island-like tiny reaction droplets at each hydrophilic bonding point, and finally under the set reaction conditions, reacting the reactants in each tiny reaction droplet. The method allows a parallel processing system for multiple reactions to be implemented under common experiment conditions, and greatly extends the application range thereof | 2015-08-13 |
20150225773 | METHODS OF DEPLETING A TARGET MOLECULE FROM AN INITIAL COLLECTION OF NUCLEIC ACIDS, AND COMPOSITIONS AND KITS FOR PRACTICING THE SAME - Provided are methods of depleting a target nucleic acid from an initial collection of nucleic acids. Aspects of the methods include contacting the initial collection with a nucleic acid guided nuclease specific for the target nucleic acid in a manner sufficient to deplete the target nucleic acid from the initial collection. Depending on a given application, depletion of a target nucleic acid may vary, e.g., where depleting may include cleaving a target nucleic acid in, or selectively separating a target nucleic acid from, the initial collection of nucleic acids. Also provided are compositions and kits for practicing embodiments of the methods. | 2015-08-13 |
20150225774 | METHODS, WORKFLOWS, KITS, APPARATUSES, AND COMPUTER PROGRAM MEDIA FOR NUCLEIC ACID SAMPLE PREPARATION FOR NUCLEIC ACID SEQUENCING - A method for preparing a nucleic acid sample for nucleic acid sequencing includes amplifying a nucleic acid target sequence using a primer bound to a first capture substrate; capturing an amplified nucleic acid product by the first capture substrate; generating at least one sequencing ladder from the amplified nucleic acid product using at least one sequencing primer; capturing the at least one sequencing ladder by hybridizing the at least one sequencing ladder to a complementary capture compound on a second capture substrate; and removing the at least one sequencing ladder from the second capture substrate. The first and/or second capture substrate may include a magnetic particle. Other methods, workflows, kits, and computer program media for nucleic acid sample preparation are also disclosed. | 2015-08-13 |
20150225775 | PCR PRIMERS - The present disclosure provides methods, compositions, and kits for performing PCR (including multiplex PCR). The methods, compositions and kits provided herein use one or more primer pairs that contain one or more cleavable bases located at a minimal distance away from the 3′ termini of the primers, and increase the accuracy of downstream analysis of sequence data. | 2015-08-13 |
20150225776 | GENE EXPRESSION PROFILING FROM FFPE SAMPLES - Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can electronically stored and implemented as well as used to augment diagnosis and treatment of diseases. | 2015-08-13 |
20150225777 | CAPSULE ARRAY DEVICES AND METHODS OF USE - This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis. | 2015-08-13 |
20150225778 | CAPSULE ARRAY DEVICES AND METHODS OF USE - This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis. | 2015-08-13 |
20150225779 | SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION OF DNA - A system and method for amplifying and detecting nucleic acids are disclosed. In one embodiment, the system includes: a microfluidic device comprising a channel for receiving a sample of solution containing real-time PCR reagents; a temperature control system configured to cycle the temperature of the sample; an excitation source for illuminating the sample; a fiber optic probe comprising (i) an optical fiber having a distal end and a proximal end and (ii) a probe head connected to the distal end of the optical fiber and positioned between the distal end of the optical fiber and the channel; and a detector configured to detect emissions exiting the proximal end of the optical fiber. | 2015-08-13 |
20150225780 | METHODS FOR RAPID DETECTION AND IDENTIFICATION OF BIOAGENTS IN EPIDEMIOLOGICAL AND FORENSIC INVESTIGATIONS - The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents. | 2015-08-13 |
20150225781 | SILVER NANOCLUSTER PROBE AND TARGET POLYNUCLEOTIDE DETECTION METHOD USING SAME, AND SILVER NANOCLUSTER PROBE DESIGN METHOD - The present invention provides a silver nanocluster probe which comprises a silver nanoparticle binding region and a specific nucleotide sequence region that specifically binds to a target polynucleotide, wherein the silver nanocluster probe is configured such that it will emit detectable light when silver nanoparticles bind to the silver nanoparticle binding region to form a silver nanocluster, but light emission from the silver nanocluster probe will decrease or decay when the target polynucleotide binds to the specific nucleotide sequence region. According to the present invention, either the presence of a target polynucleotide in a sample or a mutation in the target polynucleotide can be detected in a rapid and convenient manner by determining whether light emission decreases or decays when the target polynucleotide binds to the specific nucleotide sequence region of the silver nanocluster probe that emits detectable light. | 2015-08-13 |
20150225782 | RNASE H-BASED ASSAYS UTILIZING MODIFIED RNA MONOMERS - The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3′ end of the oligonucleotide. These compounds offer an added level of specificity previously unseen. Methods for performing nucleic acid amplification, ligation and sequencing are also provided. Additionally, kits containing the oligonucleotides are also disclosed herein. | 2015-08-13 |
20150225783 | NONDESTRUCTIVE COLLECTION OF EVIDENCE - A system and method of identifying a print includes an image-capturing and lighting optical system configured to maximize specular reflection of light reflected from a print and to minimize diffused reflection of light reflected from a background surface of the print via adjustment of at least one of a frequency and a reflection angle of the light emitted upon a sample of the print. The system and method also include an IC having one or more FETs with a nanostructure configured to detect a plurality of analytes from the print. The system and method also include a nucleic acid analyzer configured to process the print and to determine a DNA content of the print. There is no contact made with the print, while being subjected to processing by the image-capturing and lighting optical system and the IC. | 2015-08-13 |
20150225784 | COMPOSITIONS AND METHODS FOR DETERMINING THE LIKELIHOOD OF APPENDICITIS - A method for determining a likelihood of appendicitis in a subject is disclosed. The method comprises the steps of (a) determining the relative abundance of microorganisms corresponding to one or more operational taxonomic units (OTUs) in a test biological sample obtained from the subject; (b) comparing the relative abundance of the microorganisms in each of the one or more OTUs to a corresponding reference value assigned to each of the one or more OTUs, and (c) determining a likelihood of appendicitis in the subject based on the result in step (b), wherein a significant increase in relative abundance of the microorganisms in the one or more OTUs indicates a high risk of appendicitis in the subject. Also disclosed is a kit for determining a likelihood of appendicitis in a subject. | 2015-08-13 |
20150225785 | COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING - The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group. | 2015-08-13 |
20150225786 | CHROMOSOME CONFORMATION CAPTURE IN PARTITIONS - Methods compositions and kits are provided for performing a chromatin or chromosome conformation capture assay in partitions. | 2015-08-13 |
20150225787 | METHODS FOR SEQUENCING POLYNUCLEOTIDES - Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first portion of each polynucleotide molecule is attached to a first location of the surface and a second portion of each polynucleotide molecule is attached to a second location of the surface, the relative proximity of the first and second locations being correlated with the probability that the first and second portions are paired, separating the first and second portions of the polynucleotide molecules on the surface, determining the sequences of the first and second portions of the polynucleotide molecules and comparing the relative proximities and the sequences to determine which first and second portions are paired and to determine the sequence of the target polynucleotide molecules. | 2015-08-13 |
20150225788 | RISK ASSESSMENT FOR PHENYTOIN-INDUCED ADVERSE DRUG REACTIONS - A method of predicting the risk of a patient for developing phenytoin-induced adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reactions with eosinophilia and systemic symptoms (DRESS) is disclosed. Genetic polymorphisms of CYP2C genes (including rs1057910 (CYP2C9*3) and rs3758581 on CYP2C19), and HLA alleles (including HLA-B*1502, HLA-B*1301, and HLA-B*5101) can predict adverse reactions caused by phenytoin or fosphenytoin. Accordingly, the present invention provides a kit to assess the risk of a patient for developing adverse reactions in response to phenytoin-related drugs, which comprises the determination of the presence of a specific allele selected from the group consisting of rs1057910 (CYP2C9*3), rs3758581 on CYP2C19, HLA-B*1502, HLA-B*1301, and HLA-B*5101, wherein the presence of at least one allele is indicative of a risk for the adverse drug reactions. | 2015-08-13 |
20150225789 | HAPLOTYING OF HLA LOCI WITH ULTRA-DEEP SHOTGUN SEQUENCING - Methods are provided to determine the entire genomic region of a particular HLA locus including both intron and exons. The resultant consensus sequences provides linkage information between different exons, and produces the unique sequence from each of the two genes from the individual sample being typed. The sequence information in intron regions along with the exon sequences provides an accurate HLA haplotype. | 2015-08-13 |
20150225790 | METHODS FOR IDENTIFYING SUBJECTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO CCR1 ANTAGONIST - The invention describes a method for identifying subjects with an increased likelihood of responding to treatments that modulate chemokine or chemokine receptor activity by measuring the change in expression of immune mediated genes. | 2015-08-13 |