31st week of 2010 patent applcation highlights part 57 |
Patent application number | Title | Published |
20100197880 | ETHYLENE/a- OLEFIN INTERPOLYMERS CONTAINING LOW CRYSTALI.INITY HARD BLOCKS - The invention is related to an ethylene/α-olefin interpolymer having at least a hard segment and at least a soft segment. The soft segment contains a higher amount of comonomers than the hard segment. The hard segment has low crystallinity. The copolymer has a number of unique characteristics disclosed herein.ethylene/α-olefin interpolymers containing low crystallinity hard blocks | 2010-08-05 |
20100197881 | SEQUENTIALLY CROSS-LINKED POLYETHYLENE - A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. If applied to a finished polyethylene part, the irradiation and annealing must be accomplished with the polyethylene material not in contact with oxygen at a concentration greater than 1% oxygen volume by volume. When applied to a preform, such as a rod, the annealing of the bulk polymer part of the rod from which the finished part is made must take place on the rod before the implant is machined therefrom and exposed to oxygen. | 2010-08-05 |
20100197882 | Composite material engineered from metal and resin and production method thereof - A composite material engineered from metal and resin and a production method of the composite material. The composite material includes a metal portion composed of metal; a resin portion composed of resin; a polar functional group imparted to a surface of the metal portion; and an adhesion modifying agent mixed in the resin and including an adhesive functional group which interacts with the polar functional group. The metal portion and the resin portion are bonded by the interaction between the polar functional group and the adhesive functional group. | 2010-08-05 |
20100197883 | POLYESTER RESIN AND FABRICATION METHOD THEREOF - A polyester resin and a fabrication method thereof are provided. The fabrication method includes providing a diphenol monomer and a diacid monomer. The diphenol monomer is acetylated and then melt pre-polymerized with diacid monomer to form a pre-polymer. Then, the pre-polymer is polymerized by solid state polymerization to form a heat-resistant and transparent polyester resin. | 2010-08-05 |
20100197884 | METHOD FOR MAKING COPOLYMERS OF LACTIDE AND A 1:4-3:6 DIANHYDROHEXITOL - Polyester-carbonate copolymers are prepared by copolymerizing lactide with a 1:4-3:6 dianhydrohexitol in the presence of a carbonate precursor and a polymerization catalyst. The copolymers have an elevated glass transition temperature, relative to polylactide resins. | 2010-08-05 |
20100197885 | POLYMER EXTRACTION METHODS - A method of separating a polymer from a biomass containing the polymer, includes contacting the biomass with a solvent system, the solvent system including a solvent for the polymer and a precipitant for the polymer, to provide a residual biomass and a solution that includes the polymer, the solvent for the polymer and the precipitant for the polymer; and applying a centrifugal force to the solution and residual biomass to separate at least some of the solution from the residual biomass; where, the polymer is a polyhydroxyalkanoate; the precipitant comprises at least one alkane; the solvent for the polymer is selected from the group consisting of ketones, esters and alcohols and combinations thereof; and the biomass comprises a slurry of the biomass and water. | 2010-08-05 |
20100197886 | MODIFIED POLYMER COMPLEX, COMPLEX MONOMER, POLYMER COMPLEX, AND REDOX,CATALYST - A modified polymer complex, which is obtained by intermolecular and/or intramolecular crosslinking of a polymer complex via side chains thereof, wherein the polymer complex is a copolymer of a complex monomer meeting the following conditions (i) to (iii) and a comonomer expressed by the following general formula (1): R | 2010-08-05 |
20100197887 | PHOSPHORUS-CONTAINING POLYCARBONATE POLYOL, METHOD FOR PRODUCTION THEREOF, AND PHOSPHORUS-CONTAINING POLYCARBONATE POLYURETHANE - The phosphorus-containing polycarbonate polyol disclosed herein has a structural unit (I) represented by a formula: —OCOO— and a structural unit (II) represented by a residue A, wherein A denotes a n-valent residue in which n of alcoholic hydroxyl groups are removed from a phosphorus compound having at least n of alcoholic hydroxyl groups, in which n is an integer of 2 or larger, and wherein a terminal group of the polyol is a alcoholic hydroxyl group. The novel phosphorus-containing polycarbonate polyol, as a reactive flame-retardant agent, can provide flame-retardant properties easily to polyurethane or the like. | 2010-08-05 |
20100197888 | Method for Manufacturing Linear Polyethylenimine (PEI) for Transfection Purpose and Linear PEI Obtained with Such Method - The invention concerns a method of synthesising and preparing linear polyethylenimine (PEI) for use as a transfection vector, and the product obtained with such a method. It comprises drying a monomer 2-ethyl-2-oxazoline and polymerising said monomer for obtaining poly (2-ethyl-2-oxazoline) (PEOX) by: using acetonitrile as solvent, adding a dried initiator of the reaction of polymerisation, and mixing them altogether, purifying said obtained PEOX by evaporation, while performing at least three times successive washing/precipitation steps with methanol and diethyl ether and corresponding filtrations, in order to obtain (i), by performing 1H-NMR tests, correct identification of said PEOX polymer, confirmation of absence of monomer to a level <1.0% and confirmation of absence of solvent to a level <5.0% and (ii), by performing Gel Permeation Chromatography, a mean of molecular weight (Mw)>23,000 Da and polydispersity (Mw/Mn) of said PEOX<1.5, hydrolysing said PEOX. | 2010-08-05 |
20100197889 | POLYPEPTIDE AS STANDARD FOR PROTEOME ANALYSIS - The present invention provides a polypeptide as standard for peptide analysis by mass spectrometry comprising at least 16 peptides selected from the group consisting of the peptides of SEQ ID NO: 1 to SEQ ID NO: 22 or variants thereof, together with an artificial protein comprising the polypeptide, a vector comprising a nucleic acid encoding the polypeptide, a kit for proteome analysis, a selection of peptides for calibration an devaluation of mass spectrometers and chromatographs for proteome analyses and uses thereof. | 2010-08-05 |
20100197890 | Anti-cancer protein-platinum conjugates - The invention provides polypeptide-platinum conjugates comprising an anti-cancer platinum complex conjugated to polypeptides that bind relatively specifically to cancer cells, so as to direct the conjugates to cancer cells resulting in increased anti-cancer efficacy and decreased side-effects as compared to cisplatin and other conventional anti-cancer platinum complexes. | 2010-08-05 |
20100197891 | METHOD FOR PEPTIDE SYNTHESIS - A new method of anchoring a growing peptide chain during chemical synthesis to a solid-phase support is devised. Novel amino acid derivatives and peptide derivatives, both unbonded and bonded to a solid-phase support, are also provided. | 2010-08-05 |
20100197892 | ORGANOSILICON-FUNCTIONAL PHASE TRANSFER CATALYSTS - Organosilicon-functional phase transfer catalysts (PTCs) and methods for transferring immiscible molecules into a silicon-functional phase employing an organosilicon-functional PTC are provided. | 2010-08-05 |
20100197893 | METHOD TO PRODUCE FIBRIN MONOMER IN ACID MEDIA FOR USE AS TISSUE SEALANT - ClotFoam is an hemostatic agent designed for use in cases of non-compressible hemorrhage. It can be applied outside the operating room through a mixing needle and/or a spray injection method following abdominal, chest, extremities or other intracavitary severe trauma to promote hemostasis, or it can be used in the operating room for laparoscopic procedures or other surgical procedures in which compression is not possible or recommended. Its crosslinking technology generates an adhesive three-dimensional polymeric network or scaffold that carries a fibrin sealant required for hemostasis. When mixed, Clotfoam produces a foam that spreads throughout a body cavity reaching the lacerated tissue to seal tissue and promote the coagulation cascade. The viscoelastic attachment properties of the foam as well as the rapid formation of a fibrin clot that ensure that the sealant remains at the site of application without being washed away by blood or displaced by movement of the target tissue. The fibrin components are produced by a novel method which does not present thrombin to immune system and can be maintained in solution for six weeks without significant proteolytic degradation. | 2010-08-05 |
20100197894 | METHOD AND APPARATUS FOR MATERIAL SEPARATION USING ACOUSTIC ENERGY - A method and apparatus for exposing a sample, including a liquid and another material, to sonic energy to produce a desired result such as, suspending a material support in the liquid. The material support may be a bead or other particle with at least one surface feature to which the material may bind. Material in the liquid may attach to the material support, such as by specific or non-specific binding, entrapment or other, so as to facilitate separation of the material from the liquid. Separation of the material supports from the liquid and other unbound material may be done by allowing the material supports to settle out, e.g., under the force of gravity and/or as assisted by centrifugation, by applying a magnetic field in case the supports or material bound to the supports are movable by way of a magnetic field, or other techniques. | 2010-08-05 |
20100197895 | ANTIBODIES TO HUMAN TUMOR NECROSIS FACTOR RECEPTOR - Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as “Ztnfr12.” | 2010-08-05 |
20100197896 | FUNCTIONAL HUMANIZATION OF COMPLEMENTARITY DETERMINING REGIONS (CDRS) - Current humanization approaches for immunoglobulins focus mostly on modifying the framework regions into human sequences. Herein is provided a method for humanizing antibody complementarity-determining regions (CDRs) through functional humanization to reduce the potential immunogenicity of non-human CDR-containing antibodies. CDRs with high sequence homology to the parent CDR are identified from a database of human CDR sequences. One or more human CDRs that are highly homologous to the parent CDR sequence can be used to replace the corresponding CDRs of murine immunoglobulins (or their humanized, or re-engineered versions). Human CDRs that improve or have minimal effects on the antigen binding affinity and specificity are adopted. | 2010-08-05 |
20100197897 | BINDING MOLECULES - The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions. | 2010-08-05 |
20100197898 | USE OF URSOLIC ACID SAPONIN,OLEANOLIC ACID SAPONIN IN PREPARATION OF INCREASING LEUCOCYTES AND/OR PLATELET MEDICINE - The invention provides the use of ursolic acid saponin and oleanolic acid saponin of formula (I) in preparing medicaments for increasing leucocytes and/or platelets. The invention also provides a pharmaceutical composition containing the same compound. The invention utilizes the cheap and accessible ursolic acid and oleanolic acid which are widely present in natural plants as raw materials, introduces monosaccharyls or oligosaccharyls by structural modification. It is proved by pharmacological tests that the compound of formula (I) have an activity of obviously increasing leucocytes and/or platelets. | 2010-08-05 |
20100197899 | SINGLE-STRANDED AND DOUBLE-STRANDED OLIGONUCLEOTIDES COMPRISING A 2-ARYLPROPYL MOIETY - The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improvise the pharmacokinetic properties of the oligonucleotide. The aralkyl ligands of the present invention include naproxen, ibuprofen, and derivatives thereof. The present invention also provides method for modulating gene expression using the modified oligonucleotide compounds and compositions comprising those modified oligonucleotides. | 2010-08-05 |
20100197900 | MODULATORS OF COAGULATION FACTORS - The invention provides improved nucleic acid ligands that inhibit coagulation and improved modulators of the nucleic acid ligands to provide ideal modulators of coagulation. These improved nucleic acid ligands and modulators are particularly useful for inhibiting coagulation in a host undergoing a therapeutic regime such as surgery or coronary artery bypass. | 2010-08-05 |
20100197901 | DEPROTECTION AND PURIFICATION OF OLIGONUCLEOTIDES AND THEIR DERIVATIVES - Method for synthesis, deprotection, and/or purification of nucleic acid molecules, such as oligonucleotides comprising one or more ribonucleotides. Such nucleic acid molecules include siRNA, dsRNA, ribozymes, antisense, and aptamers. | 2010-08-05 |
20100197902 | NUCLEIC ACID SYNTHESIZING DIMER AMIDITE AND NUCLEIC ACID SYNTHESIZING METHOD - A nucleic acid synthesizing dimer amidite including two nucleoside compounds, wherein the two nucleoside compounds are linked with each other via a phosphite triester bond. | 2010-08-05 |
20100197903 | METHOD FOR ISOLATING A NUCLEIC ACID USING PARTICULATE MATTER AND A COMPOSITION THEREFOR - Disclosed are a method for isolating a nucleic acid using particulate matter and a composition therefor. The method comprises essentially the steps of adding a lysis buffer and a neutralization buffer to a biological sample sequentially, and centrifuging cell lysates for at least 10 minutes to separate a solution comprising the nucleic acid and insoluble aggregate comprising denatured protein aggregate and cell debris. The particulate matter is added to and participates in co-aggregation and co-precipitation of denatured protein aggregate and cell debris, and co-aggregates and co-precipitates denatured protein aggregate and cell debris within a much shortened time, thereby to shorten the time and to increase the yield for the isolation of a nucleic acid, compared with conventional methods. | 2010-08-05 |
20100197904 | CATIONIZED HYALURONIC ACID AND/OR SALT THEREOF, METHOD OF PRODUCING THE SAME, HAIR MODIFYING AGENT, CUTICLE REPAIRING AGENT, SKIN MODIFYING AGENT, AND COSMETIC PREPARATION EACH USING THE SAME - A cationized hyaluronic acid and/or a salt thereof includes a quaternary ammonium group-containing group, and has a degree of cationization of 0.15 to 0.6. | 2010-08-05 |
20100197905 | MODIFIED POLYSACCHARIDES - Modified polysaccharide polymers for use as anti-sealant and dispersant. The polymers are useful in compositions used in aqueous systems. The modified polysaccharides are also useful in detergent formulations, water treatment, dispersants and oilfield applications and as fiberglass binders. Such applications include a modified polysaccharide having up to about 70 mole % carboxyl groups per mole of polysaccharide ASU and up to about 20 mole % aldehyde groups per mole of polysaccharide ASU. The applications can also include a blend of modified polysaccharides and other synthetic polymers. | 2010-08-05 |
20100197906 | Method for purification of chlorinated sucrose derivatives from reaction mixture by chromatography - A chromatographic process of DMF removal from an aqueous composition is described comprising its loading on a column of hydrophobic fixed bed adsorbent and eluting out DMF with an aqueous alkaline buffer. This method is useful to remove DMF as a process of general application wherever simultaneous removal and isolation of DMF is desired from an organic molecule which is not an organic solvent, is soluble in DMF. This method can be used for simultaneous removal of DMF from reaction mixtures and isolation of Trichlorogalactose (TGS) or TGS-6-acetate in a process of production of TGS. | 2010-08-05 |
20100197907 | Phosphorus-containing compounds & uses thereof - This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: | 2010-08-05 |
20100197908 | Pyridazine Derivatives with MCH Antagonistic Activity and Medicaments Comprising These Compounds - The present invention relates to compounds of general formula I | 2010-08-05 |
20100197909 | MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBTITUENT AT 14-POSITION - To provide a novel mutilin derivative having a substitution at the 14-position, which is a novel mutilin analogue exhibiting a potent and broad antimicrobial action against Gram-positive bacteria and Gram-negative bacteria including various drug-resistant bacteria, and which is expected to be useful as an agent for treating infectious diseases. A mutilin derivative represented by the following general formula (1): | 2010-08-05 |
20100197910 | PROCESS FOR PREPARATION OF PRULIFLOXACIN USING NOVEL INTERMEDIATES - The present invention provides a novel process for the preparation of the prulifloxacin intermediate, 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3] thiazeto[3,2-a]quinoline-3-carboxylic acid, thereby producing prulifloxacin and its pharmaceutical acceptable acid addition salts thereof in high purity and in high yield using novel intermediates in lesser reaction time. Thus, for example, ethyl 6,7-difluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate is reacted with boric acid in the presence of acetic anhydride and acetic acid to give a borane compound, which is then condensed with piperazine in the presence of acetonitrile and dimethylsulfoxide, followed by treatment with potassium hydroxide solution to give 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3] thiazeto [3,2-a]quinoline-3-carboxylic acid. | 2010-08-05 |
20100197911 | Nitrogen-Containing Aromatic Derivatives - Compounds represented by the following general formula: | 2010-08-05 |
20100197912 | Polymorphic and hydrate forms, salts and process for preparing 6-quinoline - The invention relates to novel polymorphic and hydrate forms and salts of 6-{difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline, to methods for their preparation, to pharmaceutical compositions comprising at least one of said polymorphic or hydrate forms or salts, and to the therapeutic and/or prophylactic use of such compositions. The invention also provides new manners for preparing said compound. | 2010-08-05 |
20100197913 | NON-NUCLEOTIDE COMPOSITION FOR INHIBITING PLATELET AGGREGATION - This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y | 2010-08-05 |
20100197914 | Purine Derivatives as Adenosine Al Receptor Ligands - Compounds of formula (I), their preparation and use as pharmaceuticals (I), wherein X, Y, and Z are as defined herein. | 2010-08-05 |
20100197915 | LAPATINIB INTERMEDIATES - The invention provides lapatinib intermediates and improved processes for preparing lapatinib intermediates. The invention also provides processes for preparing lapatinib base and lapatinib ditosylate. | 2010-08-05 |
20100197916 | DIASTEREOMERIC PURIFICATION OF ROSUVASTATIN - The invention relates to diastereomerically pure rosuvastatin and processes for preparing diastereomerically pure rosuvastatin and its intermediates. | 2010-08-05 |
20100197917 | COUMARIN DERIVATIVES USEFUL AS TNF ALPHA INHIBITORS - Novel compounds composition capable of inhibiting TNFα and having antiimmunionflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds. | 2010-08-05 |
20100197918 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES - The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades. | 2010-08-05 |
20100197919 | METHOD FOR PRODUCING MACROLIDE COMPOUND AND PRODUCTION INTERMEDIATE THEREOF - The present invention provides a method for producing a 12-membered ring macrolide compound expected as a prophylactic or therapeutic agent for solid tumors and the like, and a production intermediate thereof. In detail, by acetalizing hydroxyl groups at 6- and 7-positions of a 12-membered ring macrolide compound being a raw material with dialkyl tin (IV) oxide and, after that, reacting the product with a carbamoyl halide derivative, the 7-position urethane derivative of the 12-membered ring macrolide compound being the target is effectively produced, without protecting hydroxyl groups at other positions. | 2010-08-05 |
20100197920 | N-HETEROCYCLIC CARBENE METALLACYCLE CATALYSTS AND METHODS - The present invention generally relates to materials and methods for catalytic reactions, including transition metal-catalyzed cross-coupling reactions. The materials may be stable metal complexes that do not require special handling or processing conditions. In some cases, materials of the invention advantageously may be synthesize in one synthetic step without the need for isolation of intermediate compounds. Also, materials of the invention may be synthesized from inexpensive and readily available starting materials, under relatively mild reaction conditions that do not require the exclusion of air, water, and the like. In some embodiments, the material is a N-heterocyclic carbene metallacycle complex. Such materials and methods may be useful in the production of fine chemicals, advanced materials and specialty polymers. | 2010-08-05 |
20100197921 | Preparation of N-Alkylated Opiates by Reductive Amination - The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source. | 2010-08-05 |
20100197922 | AZABICYCLOALKANE COMPOUNDS - This invention provides compounds of formula I: | 2010-08-05 |
20100197923 | SALTS OF CLOPIDOGREL AND PROCESS FOR PREPARATION - Disclosed are new salts of Clopidogrel viz. Clopidogrel mesylate, Clopidogrel besylate and Clopidogrel tosylate, methods for their preparation and pharmaceutical compositions containing them and their use in medicine. | 2010-08-05 |
20100197924 | PREPARATION OF AMINOTETRALIN COMPOUNDS - The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention. | 2010-08-05 |
20100197925 | FUNGICIDE N-CYCLOALKYL-N-BICYCLIC-CARBOXAMIDE DERIVATIVES - The present invention relates N-cycloalkyl-N-bicyclic-carboxamide, thiocarboxamide or N-substituted carboximidamide derivatives of formula (I) wherein A represents a carbo-linked, 5-membered heterocyclyl group; T represents O, S, N—R | 2010-08-05 |
20100197926 | METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING - It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with N-methyl-1-(piperidin-4-yl)-1H-indole-6-carboxamide. | 2010-08-05 |
20100197927 | Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof - PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors. | 2010-08-05 |
20100197928 | METHOD FOR PREPARING DISUBSTITUTED PIPERIDINE AND INTERMEDIATES - The disclosure relates to a method for preparing a compound of formula (I), wherein P | 2010-08-05 |
20100197929 | METHODS OF SYNTHESIZING PHARMACEUTICAL SALTS OF A FACTOR XA INHIBITOR - Novel methods of preparing a compound of Formula I which is an inhibitor of Factor Xa and its maleate salt, are described herein. | 2010-08-05 |
20100197930 | PROCESS FOR PRODUCING TOLUIDINE COMPOUND - Because fluazinam is excellent as an active ingredient of pesticides and highly useful, it is desired to produce it efficiently in a proper form with simple operations at low cost in an environmentally friendly manner. The desired product is obtained in good yields with simple operations by using industrially advantageous reaction systems by a process comprising (1) a step of reacting ACTF and DCDNBTF in the presence of an alkali component, a solvent selected from the group consisting of ketones, nitriles, ethers and esters and a sufficient amount of water to substantially dissolve the alkali component, (2) a step of neutralizing or acidifying the reaction mixture with an acid and (3) a step of removing the solvent by distillation from the mixture containing fluazinam as the reaction product and the reaction solvent to precipitate crystals the product. | 2010-08-05 |
20100197931 | CRYSTALLINE FORM OF THE ZOLEDRONIC ACID, A PROCESS TO OBTAIN IT AND THE PHARMACEUTICAL COMPOSITION COMPRISING IT - A new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises. | 2010-08-05 |
20100197932 | PROCESS FOR PREPARING PURE VALSARTAN - An improved process for the preparation of substantially pure valsartan employing suitable reagents such as chelating agent and reaction conditions. | 2010-08-05 |
20100197933 | Process for the Preparation of Candesartan Cilexetil - The present invention provides an improved synthesis for the manufacture of candesartan and pharmaceutically acceptable salts and esters thereof as active ingredients of a medicament for the treatment of hypertension and related diseases and conditions which comprises the removal of the tetrazolyl protecting group in an organic solvent, and in the presence of a Lewis acid. | 2010-08-05 |
20100197934 | PROCESS FOR PRODUCING OPTICALLY ACTIVE ALPHA-METHYLCYSTEINE DERIVATIVE - The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis. | 2010-08-05 |
20100197935 | CRYSTALLINE FORM OF THE ZOLEDRONIC ACID, A PROCESS TO OBTAIN IT AND THE PHARMACEUTICAL COMPOSITION COMPRISING IT - A method to obtain a new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises. | 2010-08-05 |
20100197936 | NOVEL EPOXY COMPOUND AND PRODUCTION PROCESS OF SAME - A novel epoxy compound represented by the following general formula (I), and a production process thereof, is provided: | 2010-08-05 |
20100197937 | NOVEL COMPOUND, PROBE CONTAINING THE NOVEL COMPOUND, AND FLUORESCENCE-IMAGING CONTRAST AGENT CONTAINING THE NOVEL COMPOUND OR THE PROBE - A compound represented by Formula (1) below, | 2010-08-05 |
20100197938 | Process for producing indole compoud - There is provided a novel process for producing an indole derivative which comprises cyclizing 2-nitrobenzylcarbony compound in the presence of a catalyst comprising a Group VIII metal of the Periodic Table, characterized by conducting the cyclization in a gas atmosphere containing carbon monoxide. The process enables an indole compound to be selectively produced in a high yield from 2-nitrobenzylcarbonyl compound, and hardly yields an indoline compound as a reduction by-product that has been a problem in the catalytic hydrogenation method employing a noble metal catalyst. The indole derivative produced by the present process is useful for various fine chemical intermediates including compounds and physiologically active substances such as pharmaceuticals and agrochemicals. | 2010-08-05 |
20100197939 | PROCESS FOR THE ENANTIOSELECTIVE PREPARATION OF PREGABALIN - The invention provides a new enantioselective process for the preparation of (S)-pregabalin, or a pharmaceutical acceptable addition acid salt comprising: acid hydrolysis of the dioxolan ring of a chiral compound of general formula (I) to obtain compound of general formula (II); oxidation of compound (II) to obtain a compound of general formula (III) and transforming compound (III) into compound of general formula (IV); subjecting compound (IV) to basic hydrolysis to obtain a compound of general formula (V) which is reduced to obtain enantiomerically pure S-pregabalin. The invention also provides new chiral intermediates involved in the process. | 2010-08-05 |
20100197940 | Method for Preparing FMOC-Based Hydrolysable Linkers - A novel process for the production of Fmoc (9H-fluoren-9-ylmethoxycarbonyl)-based compounds is provided, wherein a protecting group for the 9-hydroxymethyl group of the fluorene ring system is utilized. These compounds are useful for the modification of protein and peptide drugs. | 2010-08-05 |
20100197941 | Process for the production of atorvastatin calcium in amorphous form - A process for the production of amorphous atorvastatin calcium and stabilized, amorphous atorvastatin calcium is provided. | 2010-08-05 |
20100197942 | NOVEL FLUORENE COMPOUND - A fluorene compound is provided, which is represented by the following Formula (I): | 2010-08-05 |
20100197943 | Biodiesel production unit and biodiesel compositions - A biodiesel composition and method are disclosed and claimed whereby a biodiesel fuel is produced without glycerin waste and which has a could point below 32° F. | 2010-08-05 |
20100197944 | DOCETAXEL PROCESS AND POLYMORPHS - Processes for preparing substantially pure docetaxel, new crystalline forms of docetaxel and processes for preparation thereof, processes for preparing docetaxel trihydrate, and pharmaceutical compositions comprising docetaxel. | 2010-08-05 |
20100197945 | METHOD FOR PRODUCING PROPYLENE OXIDE - There is disclosed a method for producing propylene oxide, which includes: reacting propylene, oxygen, and hydrogen in the presence of a noble metal catalyst and a titanosilicate catalyst in a liquid phase containing a polycyclic compound, which is unsubstituted or substituted with at least one substituent selected from Group B below, wherein the polycyclic compound is composed of two or more identical or different ring compounds selected from Group A below and the ring compounds are fused, directly bonded, or bonded by a linkage group selected from the group consisting of an oxygen atom, carbon chain, and a group composed of oxygen atom(s) and a carbon chain, provided that said polycyclic compound is not a polycyclic compound having hydroxy groups or oxo groups at para or. ortho positions. Group A consisting of benzene, cyclopentadiene, cycloheptatriene, furane, pyrane, cyclopentene, cyclopentane, cyclohexane, cyclohexene, cyclohexadiene, cycloheptane, cycloheptene, and cycloheptadiene. Group B consisting of halogen atom, alkyl group, alkenyl group, alkoxy group, hydroxyalkyl group, acyl group, oxo group, hydroxy group, and cyano group. | 2010-08-05 |
20100197946 | METHOD FOR PRODUCING PROPYLENE OXIDE - A method is for producing propylene oxide, the method including the steps of: reacting hydrogen peroxide with propylene either in an acetonitrile solvent or in a mixture of solvents which include acetonitrile and water, in presence of a titanosilicate catalyst, whereby a reaction mixture containing propylene oxide is obtained; separating the reaction mixture obtained in the reacting into a gas and a reaction liquid; and distilling the reaction liquid obtained in the separating, whereby the reaction liquid is separated into a column top liquid containing propylene oxide, and a column bottom liquid including acetonitrile or a combination of acetonitrile and water, in combination with other steps. This enables industrially efficient production of propylene oxide with use of acetonitrile. | 2010-08-05 |
20100197947 | APPARATUS AND METHOD FOR PRODUCING EPOXY COMPOUND - The present invention provides an apparatus for producing an epoxy compound derived from an olefin by causing a reaction of hydrogen, oxygen, and the olefin in a liquid solvent in the presence of a catalyst in a reactor, wherein a vapor phase in the reactor contains an inert gas; hydrogen, an oxygen-containing gas with an oxygen concentration of at least 90% by volume, and the olefin are supplied to the vapor phase and/or liquid phase of the reactor to cause a reaction; and there exist a means for taking out the liquid phase containing the reaction product from the reactor. | 2010-08-05 |
20100197948 | Inhibitors of yeast filamentous growth and method of their manufacture - The invention broadly relates to the use of α,β-unsaturated fatty acids to inhibit the filamentous growth of fungi and yeasts and to a method for producing same. In particular the invention relates to the use of optionally substituted C8 to C15 α,β-unsaturated fatty acids or salts, esters or amides thereof for inhibiting or retarding the yeast-to-mycelium transition of organisms having a dimorphic life cycle. | 2010-08-05 |
20100197949 | PROCESS FOR PREPARING ORGANOSILICON COMPOUNDS CONTAINING ORGANYLOXY GROUPS - Organosilicon compounds bearing silicon-bonded organyloxy groups are prepared by mixing and reacting silanol-functional organosilicon compounds with organosilicon compounds containing at least two organyloxy groups in a mixer with an energy input of at least 0.2 kW/Kg of mixture. At this level of energy input, reaction to form the organyloxy-functional product is rapid, and can be achieved without supplying external heat, and also without catalysts, if desired. | 2010-08-05 |
20100197950 | PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES - The preparation of an intermediate, a process for the preparation thereof and the process of preparing [4-[3,3-Bis-(4-bromo-phenyl)-allyloxy]-2-methyl-phenoxy]-acetic acid using this intermediate are described. | 2010-08-05 |
20100197951 | COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT - The present invention provides methods for preparing TLR-4 receptor agonist E6020: | 2010-08-05 |
20100197952 | PROCESS FOR PRODUCING DIPHENYL CARBONATE - Processes for producing diaryl carbonates are disclosed, where such processes may provide for the production of diaryl carbonates from green house gases, such as carbon dioxide. The processes disclosed advantageously integrate diethyl carbonate and diaryl carbonate production, eliminating the need for solvent-based extractive distillation, as is commonly required when producing diaryl carbonates from dimethyl carbonate, providing for the integration of separation equipment and raw material usage, and reducing the operating and capital requirements for such processes. In some embodiments, processes disclosed herein may be operated essentially closed-loop with respect to ethanol usage, for example. | 2010-08-05 |
20100197953 | LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF - Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. | 2010-08-05 |
20100197954 | SYNTHESIS OF SPHINGOSINES AND THEIR DERIVATIVES - Embodiments of the present disclosure provide for methods of making sphingosines and derivatives thereof, and the like. | 2010-08-05 |
20100197955 | METHOD FOR PRODUCING BUTANEDIOL DIMETHACRYLATES - The present invention relates to a process for preparing butanediol dimethacrylates, which comprises the transesterification of butanediol with an ester of methacrylic acid in the presence of catalysts, wherein a combination comprising at least one lithium compound and at least one calcium compound is used as catalyst, at least one of the compounds of lithium and/or of calcium is an oxide, a hydroxide, an alkoxide having from 1 to 4 carbon atoms or a carboxylate having from 1 to 4 carbon atoms and at least part of the reaction is carried out in the presence of an effective amount of water. The process of the invention makes a particularly inexpensive preparation of butanediol dimethacrylates having a very high purity possible. | 2010-08-05 |
20100197956 | Vam Shell Catalyst, Method For Its Production And Use Thereof - A shell catalyst for the production of vinyl acetate monomer (VAM), comprising a porous catalyst support based on a natural sheet silicate, in particular based on an acid-treated calcined bentonite, said catalyst support being loaded with Pd and Au and being designed as a shaped body. In order to provide a shell catalyst for the production of VAM, which shell catalyst is characterized by a relatively high VAM selectivity and also a high activity, it is proposed that the catalyst support has a surface area of less than 130 m | 2010-08-05 |
20100197957 | Method for Producing Fluorine-Containing Carboxylic Acid Ester - [Task] It is to provide a production method that the target fluorine-containing carboxylic acid ester can be obtained from a fluorine-containing ether by a one-step reaction, that a complicated step and a troublesome operation are not necessary, and that an excessive energy is not consumed. | 2010-08-05 |
20100197958 | PROCESS FOR THE CARBONYLATION OF AN ETHYLENICALLY UNSATURATED COMPOUND AND A CATALYST SYSTEM - A process for the carbonylation of an ethylenically unsaturated compound comprising the step of reacting said compound with carbon monoxide in the presence of a co-5 reactant having a mobile hydrogen atom and a catalyst system is described. The catalyst system is obtainable by combining: (a) a metal of Group 8, 9 or 10 or a suitable compound thereof; (b) a ligand of general formula (I): and c) optionally, a source of anions. The invention is characterised in that the catalyst system includes an enhancer compound comprising an aromatic ring or ring system substituted by at least one hydroxyl group wherein the hydroxyl group pKa at 25° C. is greater than 3.0 and less than 9.1, the said enhancer compound excluding 3-quinolinol. Catalyst systems for use with the enhancer compound are described as are a method of increasing the efficacy of a catalyst system for the carbonylation of ethylenically unsaturated compounds and a method of increasing the rate of carbonylation of an ethylenically unsaturated compound comprising the step of adding such a compound to the reaction. | 2010-08-05 |
20100197959 | PROCESSES FOR MAKING ETHYL ACETATE FROM ACETIC ACID - A process for hydrogenating acetic acid to form of ethyl acetate and mixtures of ethyl acetate and ethanol. The hydrogenation is done in the presence of catalyst, preferably on a support that optionally includes a support modifier. | 2010-08-05 |
20100197960 | METHOD FOR THE ORGANOCATALYTIC ACTIVATION OF CARBOXYLIC ACIDS FOR CHEMICAL, REACTIONS USING ORTHOSUBSTITUTED ARYLBORONIC ACIDS - The present disclosure describes operationally simple methods for the low temperature, catalytic activation of carboxylic acids for organic reactions, in particular for direct amidation reactions with amines. The methods involve the use of orthosubstituted arylboromc acids of the formula (I), wherein the groups R | 2010-08-05 |
20100197961 | ADDUCT OF 1-HYDROXYETHYLIDENE-1, 1-DIPHOSPHONIC ACID AND ETHYLENEDIAMINE DISUCCINIC ACID OR A SALT THEREOF, A METHOD FOR ITS PREPARATION, AND THE USE OF SAID ADDUCT - An adduct of 1-hydroxyethylidene-1,1-diphosphonic acid and from 0.5 to 10 moles of ethylenediamine disuccinic acid or a salt thereof per mole of 1-hydroxyethylidene-1,1-5 diphosphonic acid, wherein said adduct is in the form of a solid. | 2010-08-05 |
20100197962 | Use of Neboglamine in the Treatment of Toxicodependency - Use of neboglamine, (S)-4-amino-N(4,4-dimethyl-cyclohexyl)glutamic acid (CR 2249) (CAS Registry Number 163000-63-3), the racemic mixture thereof or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in the treatment of toxicodependency induced by drugs such as CNS sedatives such as opiates, barbiturates, benzodiazepines, alcohol, stimulants such as amphetamines and cocaine, and hallucinogens such as LSD, mescalin, cannabis (marijuana) or fencyclidine. | 2010-08-05 |
20100197963 | FLUORINATED OXY-CARBOXYLIC ACIDS, DERIVATIVES, AND METHODS OF PREPARATION - Provided are fluorinated oxy-carboxylic acids, derivatives of oxy-carboxylic acids, and methods of preparing oxy-carboxylic acids and derivatives thereof. | 2010-08-05 |
20100197964 | METHOD OF ADSORBING AND METHOD OF RECOVERING FLUORINE-CONTAINING COMPOUND - An adsorption process in which high adsorption of C | 2010-08-05 |
20100197965 | METHOD FOR THE CATALYTIC CONVERSION OF 2-HYDROXY-4-METHYLTHIOBUTANENITRILE (HMTBN) INTO 2-HYDROXY-4-METHYLTHIOBUTANAMIDE (HMTBM) - This process is carried out in the presence of a solid catalyst comprising an active phase. The catalyst is formulated and the conversion is carried out in a medium essentially free of strong mineral acid. | 2010-08-05 |
20100197966 | METHODS OF MAKING POLYBORONIC COMPOUNDS AND COMPOSITIONS RELATED THERETO - Polyboronic compounds and methods of making them are provided. The polyboronic compounds are useful as crosslinking agents. The polyboronic compounds are produced by contacting a polymeric amine with a trialkylborate in the presence of a solvent so that the resulting molecule has more than one B—N bond. | 2010-08-05 |
20100197967 | PROCESS FOR THE PURIFICATION OF ALPHA, OMEGA-DIIODOPERFLUORINATED COMPOUNDS - The invention concerns a process for purifying α,ω-diiodoperfluorinated compounds of formula 1-(CF | 2010-08-05 |
20100197968 | ALDEHYDE-AMINE FORMULATIONS AND METHOD FOR MAKING AND USING SAME - A novel method for producing amine-aldehyde sulfur scavenging compositions are disclosed, where the method comprises contacting an amine containing component and a aldehyde containing component in the presence of an alcohol at an amine to aldehyde ratio of between about 0.8 and 0.45 for a reaction time and at a reaction temperatures sufficient to produce an amine-aldehyde adduct product having a specific gravity between about 3% and 7% less than the specific gravity of a mixture of starting materials. | 2010-08-05 |
20100197969 | USE OF PHOSPHONIUM SALTS IN COUPLING REACTIONS AND PROCESS FOR THEIR MANUFACTURE - The object of the present invention is the use of phosphonium salts in coupling reactions, and a method for their preparation. | 2010-08-05 |
20100197970 | METHOD FOR PRODUCING NORBORNENE DERIVATIVE - A method for producing a norbornene derivative wherein,
| 2010-08-05 |
20100197971 | Process For Producing Cyclohexylbenzene - In a process for producing cyclohexylbenzene, benzene and hydrogen are fed to at least one reaction zone. The benzene and hydrogen are then contacted in the at least one reaction zone under hydroalkylation conditions with a catalyst system comprising a molecular sieve having an X-ray diffraction pattern including d-spacing maxima at 12.4±0.25, 6.9±0.15, 3.57±0.07 and 3.42±0.07 Angstrom, and at least one hydrogenation metal to produce an effluent containing cyclohexylbenzene. The ratio of the total number of moles of hydrogen fed to said at least one reaction zone to the number of moles of benzene fed to said at least one reaction zone is between 0.4 and 0.9:1. | 2010-08-05 |
20100197972 | PREPARATION OF A SATURATED ALDEHYDE - The invention relates to a compound according to Formula (IX) and salts thereof, wherein R | 2010-08-05 |
20100197973 | SELECTIVE PREPARATION OF SOME 2-ALKOXY-ETHANOL DERIVATIVES - A method for producing certain 2-alkoxy-ethanol derivatives by depolymerising oligomeric or polymeric polyglycol derivatives in the presence of alcoholate or 1,3-diketonate derivatives of zirconium, titanium, aluminium or molybdenum. | 2010-08-05 |
20100197974 | PROCESSES FOR MAKING DIALKYL ETHERS FROM ALCOHOLS - Processes for the preparation of dialkyl ethers from C | 2010-08-05 |
20100197975 | PROCESS FOR MAKING DIALKYL ETHERS FROM ALCOHOLS - Processes for preparing dialkyl ethers from C | 2010-08-05 |
20100197976 | CATALYSTS - Catalysts suitable for asymmetric hydrogenation reactions is described comprising the reaction product of a group 8 transition metal compound a chiral phosphine and a chiral diamine of formula (I) | 2010-08-05 |
20100197977 | Allyl diacetate decomposition - A process for purifying an acetoxylation mixture is disclosed. Allyl acetate, water, acetic acid, and from 0.1 to 10 wt. % allyl diacetate are contacted in the vapor phase with a solid acidic catalyst under conditions effective to decompose the allyl diacetate and generate an intermediate stream comprising allyl acetate, water, acetic acid, and acrolein. Acrolein is then removed from the intermediate stream, preferably by distillation, to give an allyl acetate-containing product stream. Usually, this product stream is then hydrolyzed to produce allyl alcohol. The invention includes processes in which propylene first reacts with oxygen and acetic acid in the presence of a noble metal catalyst to generate the acetoxylation mixture. | 2010-08-05 |
20100197978 | IPA From Propylene Using Mixed Metal Oxides - The invention relates to the production of isopropyl alcohol (IPA) by direct hydration of propylene over mixed transition metal oxides co-precipitated with ZrO | 2010-08-05 |
20100197979 | Catalytic Isomerization Between E and Z Isomers of 1,2,3,3,3 Pentafluoropropene Using Aluminum Catalyst - A starting material comprising 1,2,3,3,3-pentafluoropropene is contacted with an aluminum chlorofluoride (AlCl | 2010-08-05 |