| 31st week of 2022 patent applcation highlights part 8 |
| Patent application number | Title | Published |
|---|
| 20220241129 | STRETCHING DEVICE FOR THERAPY - A stretching device for therapy contains a base including a inclined foot platform axially connected with a rear end thereof and tilting backward, a frame for the inclined foot platform having a horizontal support to abut against or be connected to an upright member extending upwardly from the front end thereof, and the upright member having two handle loops mounted thereon relative to a user's waist, the inclined foot platform is lifted to be used as an oblique platform. Accordingly, the user is capable of stretching calves, hamstrings, lower back, upper back, shoulders and neck, also to provide traction to the spine. | 2022-08-04 |
| 20220241130 | DEVICE FOR RELIEVING THE LOAD ON THE HUMAN MUSCULOSKELETAL SYSTEM DURING WORK OR LEISURE - The invention relates to the field of medicine. A device for relieving the load on the human musculoskeletal system during work or leisure comprises a base, a supporting bed mounted at an angle to the base, a foot rest and a spring mechanism. The spring mechanism allows the support bed to rock relative to the base. The device is equipped with a rocking force adjustment mechanism, as well as with height-adjustable armrests and a table. The table is adjustable with respect to its position relative to a person. This provides for an improvement in the performance of the device for users of different builds, allows users to be more comfortably accommodated irrespective of their height or weight, improves levels of efficiency, reactivity and endurance in users, and provides a greater sensation of well-being and relaxation than sitting. | 2022-08-04 |
| 20220241131 | PULLEY SYSTEM FOR REMOTELY MOUNTED EXOSKELETON ACTUATORS - This application relates to an actuation system for assistive wearable devices such as exoskeletons designed to actuate a joint of a wearer of the device. The actuation system comprises a cable that connects a guide member arranged on one side of the joint and active components arranged on the other side of the joint. Applying a tension to the cable causes the cable to apply a force to the joint in a superior direction, which translates into a torque of the joint. The actuation system provides the advantages of having a low profile, and being substantially flexible, compliant, lightweight, and comfortable, while having good controllability and force delivery capabilities. | 2022-08-04 |
| 20220241132 | BODY WEIGHT LOAD REDUCTION DEVICE - A body weight unloading apparatus according to an aspect of the present invention includes a first actuator, a second actuator, a first support member, a second support member, a sensor for measuring the imbalance between floor reaction forces respectively acting on the legs of a user, and a control device for controlling operations of the actuators. One end of the support members is respectively connected to the actuators, and the other end of the support members is fitted to the user such that unloading forces that are supplied by the actuators respectively act on the legs of the user. The control device controls the actuators so as to respectively generate unloading forces determined according to the imbalance between the floor reaction forces. | 2022-08-04 |
| 20220241133 | CONTROLLER, CRUTCH AND WEARABLE ROBOT INCLUDING THE SAME - A controller includes: a head part including a display unit providing information and images and a button unit having operation buttons; and a body part joined to the head part, where the display unit includes a projection portion engaged with the body part, the body part includes a recessed portion into which the projection portion is inserted, a first uneven portion is provided on an outer circumferential surface of the projection portion, a second uneven portion having a shape corresponding to that of the first uneven portion is provided on an inner circumferential surface of the recessed portion, and at least one of the first uneven portion or the second uneven portion includes a plurality of uneven portions. | 2022-08-04 |
| 20220241134 | SAFETY CONTROL FOR MOBILITY DEVICE - A mobility device configurable in a first walk configuration and a second stair-climb configuration, including a frame with movable front leg portions, a leg-actuation system connected to the front leg portions and a safety-control device mounted to the frame. The safety-control device includes a configuration selector, and a lever connected to the leg-actuation system and configured to actuate the cable actuation system so as to cause the first and second movable leg portions to move from a first position to a second position. The lever remains locked in a first lever position such that the lever cannot be moved unless the configuration selector is in a depressed position, thereby preventing inadvertent movement of the leg portion. | 2022-08-04 |
| 20220241135 | MASSAGE ARMCHAIR, AND MASSAGE MECHANISM AND MASSAGE METHOD THEREOF - A massage mechanism includes a connecting seat, a supporting seat assembly, upper massage arms, lower massage arms, a kneading shaft and a first driving assembly. The first driving assembly is used for driving the kneading shaft to rotate, such that a connecting member and a connecting shaft are driven to perform a reciprocating motion on each supporting seat assembly, and upper massage rolling wheels and lower massage rolling wheels are close to each other or away from each other, so as to achieve a shoulder clamping action. The two upper massage arms and the upper massage rolling wheels are driven to be close to each other or away from each other, and the two lower massage arms and the lower massage rolling wheels are close to each other or away from each other, so as to achieve a kneading action. | 2022-08-04 |
| 20220241136 | FASCIA MASSAGER AND ITS METHOD OF MANUFACTURE - A fascia massager has a main body which has a rounded a main body top portion and a flat lower portion on a main body bottom. Fingers are formed on the main body along the main body bottom. The fingers protrude downwardly from the main body bottom. The fingers have a conical finger taper. A first hexagonal frame and a second hexagonal frame are formed on the main body. The fingers extend downwardly as fingers having indents between the fingers. The fingers are parallel to each other. The indents are formed on sides of the main body and have a vertical orientation parallel to the fingers. | 2022-08-04 |
| 20220241137 | PNEUMATIC COMPRESSION DEVICE WITH INTEGRATED PUMP - A pneumatic compression boot assembly includes a sleeve having a foot portion and a leg portion that cooperate to define a boot interior that is configured to receive a user's leg and foot, and a pump associated with the foot portion of the sleeve. The sleeve includes a plurality of inflatable compartments defined therein. The pump is configured to inflate the inflatable compartments. | 2022-08-04 |
| 20220241138 | VEST APPARATUS FOR PROVIDING VIBRATIONAL STIMULUS - Devices, systems, and methods for percussion therapy of a patient's torso area provide percussive force to release and/or dislodge mucous from respiratory airways of a human patient. Such devices, systems, and methods may include a torso covering for securing to a patient's torso, percussive devices coupled to the torso covering, and an attachment assembly for supporting the torso covering. The percussive devices may include a percussion frame, an electromechanically actuated percussor for controlled movement between end positions, and resilient members attached to opposite ends of the percussion frame for assisting controlled movement of the percussor. The devices, systems, and methods disclosed herein provide efficient and comfortable high-frequency percussive force to a patient's torso, reducing stress on the patient and improving patient experience. | 2022-08-04 |
| 20220241139 | DEVICE FOR TREATING VAGINAL ATROPHY | 2022-08-04 |
| 20220241140 | DEVICES, SYSTEMS AND METHODS FOR MECHANICAL TISSUE STIMULATION - A method of stimulating nasal tissues using a system comprises a catheter assembly connected to a fluid flow generator. The catheter assembly comprises a generally oblong inflatable catheter defining at least one catheter volume and a tube part comprising at least one lumen configured to establish fluid flow connection between said fluid flow generator and catheter. Preferably, the catheter assembly comprises at least one vent for releasing fluid or permitting fluid to escape from the generated fluid flow. The method generally comprises the steps of: providing a fluid flow from the fluid flow generator; inflating the catheter to assume a shape suitable for insertion in the nasal cavity; inserting the catheter to a predetermined position in a nasal cavity; adjusting the catheter with the fluid flow regulator to assume a shape suitable for stimulating the nasal tissue; and stimulating the nasal tissue by selecting at least one of a smooth continuous fluid flow, an oscillating fluid flow and a pulsating fluid flow. | 2022-08-04 |
| 20220241141 | MULTIFUNCTION KNEE BRACE OR SLEEVE - A multifunction sleeve for a jointed limb is provided. The sleeve may include multiple sections each with one or more inflatable chambers. One or more temperature sensors, one or more range of motion sensors, one or more thermal elements are provided for application of heat or cold therapy. A control device is provided which is adapted to: receive temperature data from the temperature sensors; receive range of motion data from the range of motion sensors; receive temperature data from the thermal elements; control timing, order and duration of inflation and deflation of the inflatable chambers; and control application, timing, temperature, and duration of the heat or cold therapy. A user device may be adapted to receive, store and analyze the temperature and range of motion data received from the control device and/or the sleeve. Potential adverse events may be predicted based on the data received. | 2022-08-04 |
| 20220241142 | MASSAGE APPARATUS AND METHODS OF USING SAME - A massage apparatus for the treatment of plantar fasciitis or heel pain or heel spur syndrome, comprising: a core including one or more grooves around the circumference thereof; and, one or more bands sized and shaped for insertion into the one or more grooves. | 2022-08-04 |
| 20220241143 | Hand and Forearm Therapeutic Massage System - A hand and forearm therapeutic massage system consisting of a frame that supports easily exchangeable lower fixed roller and an upper vertically movable roller. When a person inserts his or her hand and forearm between the two rollers, the upper roller provides precisely adjustable downward force thus providing a massaging action on the user's hand or forearm. A removable side panel provides easy and quick access for removal and insertion of rollers for a specific diagnosis. A cam mechanism and attached knob located in the upper portion of the frame can adjust the spring pressure exerted on the upper roller. The cam adjustment knob protrudes beyond the side wall of the hollow frame and includes an indicating arrow that points to indices affixed to the side of the hollow frame to allow a person to accurately know the pressure setting he or she is on. | 2022-08-04 |
| 20220241144 | WEARABLE MASSAGE DEVICE - A wearable massage device is provided, which includes a ring and a first belt configured for mounting and fixing a massaging device. The first belt has two opposite ends connected to two sides of the loop, and at least one end of the first belt is detachably connected to the loop. The wearable massage device provided by the present application has a simple structure and high reliability in use, and is convenient for wearing and detaching. | 2022-08-04 |
| 20220241145 | MEDICAL DEVICE FOR CONCURRENT ELECTRICAL STIMULATION - Concurrent electrical stimulation of a human being. Motion of a user is monitored based on motion and orientation signals received from motion sensors and a physical position of the user is determined based on the motion and orientation signals. A first electrode and/or one or more second electrodes are activated based on the determined physical position of the user. The first electrode is configured to provide a first electrical stimulation to a first nervous system of the user. The one or more second electrodes are configured to provide a second electrical stimulation to a second nervous system of the user. Vibrational electrodes are activated based on the determined physical position of the user. The vibration electrodes are configured to provide vibrational stimulation to an area of the user. | 2022-08-04 |
| 20220241146 | FACIAL MASK FOR SKIN CARE - A facial mask for skin care is provided. According to the present invention, provided is a facial mask for skin care, comprising: a mask member applied to the facial area of the human body; one or more vibrators provided in the mask member so as to transmit vibration to the skin; an actuating unit for transmitting the vibration of the vibrators toward the skin, and blocking the vibration transmitted to the mask member; and a control unit for individually controlling the plurality of vibrators. | 2022-08-04 |
| 20220241147 | METHOD OF CLEARING AN OBSTRUCTION IN A CHOKING PERSON - A simplified method of clearing a blockage caused by an obstruction in a person who is choking has the steps of standing the choking person behind a seat back of a chair, doubling the choking person over the seat back thereby having the choking person's head and chest pointing straight downwardly, and striking a back of the choking person repeatedly to drive the obstruction downwardly out of the throat towards the mouth of the choking person under the assistance of gravity to clear the obstruction. The method may further include the step of pressing the choking person's abdomen against the top of the seat back. | 2022-08-04 |
| 20220241148 | CONTROL BOX AND MASSAGE WATER POOL - Disclosed is a control box. The control box is internally provided with a first chamber, and the first chamber is used for accommodating a control component. The control box is also internally provided with an air supply system for supplying air to a water pool body. The air supply system comprises an air suction part having a housing, the housing is provided with an air inlet and an air outlet, and the air inlet is communicated with the first chamber; the air suction part further comprises an air pump provided in the housing, and when the air pump is started, air in the first chamber can be suctioned into the housing by means of the air inlet. The air supply system further comprises a valve part provided with a pipeline, the pipeline is provided with an air intake port and an air supply port, the air intake port is communicated with the air outlet of the housing, and the air supply port is used for being communicated with the water pool body; when the valve part is opened, the air suctioned into the housing can flow into the water pool body along the pipeline. According to the present invention, the working environment in the first chamber can be kept dry, so that the service life of the control component is prolonged. The present invention further provides a massage water pool. | 2022-08-04 |
| 20220241149 | CAP AND CAPPED VIAL - Provided is a cap including: a cap body; a protective cover; and an attaching device for attaching the protective cover and a top plate of the cap body to each other. The top plate includes: a through hole; and a top plate annular portion. The protective cover includes a cover body having a lower surface arranged away from the top plate. The attaching device includes a cover attaching portion formed into an annular shape around the through hole and projecting from the lower surface of the cover body toward the top side of the top plate annular portion or from the top side of the top plate annular portion toward the lower surface of the cover body to attach the protective cover and the top plate to each other. | 2022-08-04 |
| 20220241150 | INSULIN STORAGE AND DISPENSING SYSTEM - An insulin storage and dispensing system for housing a standard insulin bottle and securely keeping the bottle in place when using a syringe to access the port on the top of the bottle to fill the syringe while providing accessibility in the form of a convenient mounting assembly for mounting on a refrigerator, an interior cabinet door or wall. | 2022-08-04 |
| 20220241151 | An Adaptor for a Medical Container, a Medical Container Comprising Said Adaptor, and a Method for Manufacturing this Medical Container - The adaptor includes a proximal part configured to be secured onto the distal tip of the medical container, a distal part configured to receive a connector, and a remotely readable electronic component configured to allow remote identification of the medical container when the adaptor is secured to the medical container, the remotely readable electronic component being at least partially embedded into the adaptor. | 2022-08-04 |
| 20220241152 | FIBRIN BIOPOLYMER FORMATION AND APPLICATION DEVICE - The two devices described allow for greater control over application of a fibrin biopolymer and yet remain simple enough to be used by both medical personnel and by non-medical workers. One of the devices includes chambers where components necessary for formation of a fibrin biopolymer are stored and are pushed by plungers connected to an actuator upon the actuator receiving pressure from the user, with the components mixing in a chamber within the device and flowing out of a tube connected to the mixing chamber before formation of the fibrin biopolymer is completed. The other device dispenses formulations that include components necessary for formations of a fibrin biopolymer onto a skin of a patient using one or more propellants, with the formation of the fibrin biopolymer being initiated after the formulations are dispensed on the patient's skin and are intentionally mixed together. | 2022-08-04 |
| 20220241153 | MEDICATION MIXING AND LOADING APPARATUS - A multi-lumen spike for mixing and reconstituting a medication in a dry state designed to provide the ability for a lay person to aseptically reconstitute a powdered medication for use with an infusion apparatus. The multi-lumen spike can be included as part of a medication mixing and loading apparatus capable of using one or more syringes for reconstituting the medication. | 2022-08-04 |
| 20220241154 | SYSTEM AND METHOD FOR DUAL-FUNCTION SYRINGE DESIGN COMPOUNDING DEVICE FOR PERSONALIZED TREATMENTS - The present invention provides a system for preparing active agents for personalized treatment of a subject, wherein the system comprises a housing enclosing an interior space; an inventory structure comprising a plurality of chambers, wherein each chamber is capable of holding a dual-function syringe comprising a predetermined agent to be administered; means for selecting one or more dual-function syringes according to the predetermined active agent; means for moving the selected dual-function syringe to a desired location for transferring of the predetermined agent from the dual-function syringe to a product container or carrier; and means for sequentially transferring a controlled quantity of the predetermined agent from each selected dual-function syringe to the product container or carrier under positive or negative pressure. | 2022-08-04 |
| 20220241155 | PROCESS FOR PREPARING FILLED HARD-SHELL CAPSULES WITH CELLULOSE OR STARCH-BASED COATINGS WITH A CAPSULE-FILLING MACHINE - A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body in a pre-locked state or a final-locked state. The material of the body and cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer, containing one or more anionic cellulose(s), ethyl cellulose, and/or one or more starches comprising at least 35% by weight of amylose, where the coating layer is present in an amount of about 1 to 5.8 mg/cm | 2022-08-04 |
| 20220241156 | CHILD-RESISTANT DISPENSERS FOR THIN STRIP MEDICATIONS - Product containers, especially child-resistant product dispensers, and methods of use thereof. In some particular embodiments, provided herein are child-resistant medication dispensers, and methods of use thereof for administering medications to individuals that may suffer from manual dexterity problems. The disclosure is particularly useful in dispensing orally dissolving medications intended for sublingual application, such as orally dissolving strips. In one embodiment of the disclosure a medication dispenser is disclosed comprising a container having an opening and an inner chamber, a cap configured to close the opening of the container and provide a child-resistant locking engagement with the container, and a tray deployable in the chamber of the container and configured to hold at least one pouch carrying a dose of medication. The tray can include a support configured to hold one or more pouches when the tray and pouches are deployed within the container. | 2022-08-04 |
| 20220241157 | DUAL-SIDED CLEANING PACIFIER AND METHOD OF USE - A dual-sided pacifying gum and teeth cleaning device. The pacifying cleaning device is comprised of a U-shaped cleansing portion proceeding in a circular manner between the base of a nipple and a raised lip displacer. The cleansing portion has a pair of walls with sets of bristles, such that the respective sets of bristles generally face each other. As an infant sucks on the pacifying device, the position of the bristles and sucking action result in frictional contact against both the front and back of the infant's teeth, providing improved overall cleaning of teeth and gums. | 2022-08-04 |
| 20220241158 | Silver Fluoride Formulations, Methods and Devices for Caries Management - An oral care formulation includes an aqueous mixture of a water-soluble silver salt, a fluoride reagent, and a water-soluble polymer, the aqueous mixture having a viscosity ranging from about 1000 cPs to about 35,000 cPs. A method of using a fluoride and silver containing formulation, such as silver diamine fluoride, in dental applications includes providing a substrate having the formulation in a solid or semi-solid state on a portion of the substrate, positioning the substrate adjacent to dental areas, and allowing the portion of the substrate with the formulation to contact the dental areas. A disposable applicator for applying the formulation is also disclosed. | 2022-08-04 |
| 20220241159 | COSMETIC COMPOSITIONS IN A SOFT-SOLID FORMAT COMPRISING A HYDROPHOBIC POWDER SELECTED FROM SILICA AEROGEL AND POLYLACTIC ACID, STARCH AND AN UV-FILTER SYSTEM - The present invention relates to a new galenic formulation of cosmetic compositions in a soft-solid format, containing high concentration of hydrophobic compounds and high SPF values. The new galenic formulation has a higher viscosity than usual products on the market, but having desired spreadability and sensorial properties due to its unique rheology behavior. The cosmetic composition of the present invention presents enhanced anti-oiliness and anti-acne effects, as well as a dry touch after application, due to its high concentration of hydrophobic compounds. | 2022-08-04 |
| 20220241160 | Assembled Jade Activation Material for Beauty and Assembly and Synthesis Method and Application thereof - An assembled jade activation material is assembled and synthesized by the sol-gel method, and contains 55-59% tetraethyl orthosilicate, 4-8% calcium nitrate tetrahydrate, 26-30% magnesium nitrate hexahydrate, 1-8% zinc nitrate, 0-3% yeast selenium, 0-1% manganese nitrate and 0-1% copper nitrate by molar ratio, and the sum of the mole percentages of each component is 100%. The assembly method draws on the main components of natural jade materials that exert their effects, and synthesizes the assembling jade activation materials through self-assembly of sol-gel technology, uniquely increases silicon, calcium, magnesium ions, etc., and adjusts the amount of trace elements according to needs, adding zinc, selenium, manganese, copper and other elements. | 2022-08-04 |
| 20220241161 | Oral Care Compositions - An oral care composition comprising zinc phosphate, stannous fluoride and an organic acid buffer system, as well as methods of using the same. | 2022-08-04 |
| 20220241162 | Personal Care Compositions for Treating Odor Causing Bacteria and Methods for the Same - Compositions, such as personal care compositions, and methods for selectively inhibiting the growth of a detrimental bacteria and promoting the growth of a beneficial bacteria are disclosed. The composition may include a base and one or more fatty alcohols. The one or more fatty alcohols may be present in an amount effective to selectively inhibit the growth of at least one detrimental Gram-positive bacteria and promote the growth of at least one beneficial Gram-positive bacteria on skin. The detrimental Gram-positive bacteria may include | 2022-08-04 |
| 20220241163 | PREPARATION OF HYALURONIC ACID CBD CONJUGATES - A molecular structure comprising a single-stranded hyaluronic acid moiety, and a plurality of releasable cannabidiol moieties attached thereto is provided herein, as well as uses and methods of treating a skin conditions using the same. | 2022-08-04 |
| 20220241164 | Oral Care Compositions - Described herein are—inter alia—complexes comprising a curcuminoid; and an anionic surfactant. Methods of making and using same are also described. | 2022-08-04 |
| 20220241165 | ORAL CARE COMPOSITIONS COMPRISING OXALIC ACID - Oral care compositions comprising oxalic acid and pH buffering agent with a pK | 2022-08-04 |
| 20220241166 | ORAL CARE COMPOSITIONS COMPRISING OXALIC ACID - Oral care compositions comprising oxalic acid and less than 1%, by weight of the oral care composition, of cellulose derivative. Oral care compositions comprising oxalic acid and less than 1%, by weight of the oral care composition, of carboxymethylcellulose. Oral care compositions comprising oxalic acid and free of carboxymethylcellulose. | 2022-08-04 |
| 20220241167 | PRODUCT FOR TREATING KERATINOUS FIBERS, CONTAINING SILANES OF SPECIFIC FORMULAE - A cosmetic composition for the treatment of keratinous material, in particular keratinous fibers, includes
| 2022-08-04 |
| 20220241168 | COMPOSITION FOR STIMULATING BETA-ENDORPHIN PRODUCTION COMPRISING SANSHOOL - A composition includes, as an active ingredient, a substance capable of providing a useful effect to the skin by stimulating production of beta (β)-endorphin. The composition containing, as an active ingredient, sanshool, an isomer thereof, a hydrate thereof, or a solvate thereof stimulates production of β-endorphin when applied into the body, thereby providing useful effects to the skin, such as relieving skin irritation from the outside and providing a skin soothing effect. | 2022-08-04 |
| 20220241169 | USE OF DIHYDROISOQUINOLINIUM SALTS FOR TREATING KERATIN MATERIALS, COMPOSITIONS AND IMPLEMENTATION PROCESSES - Use of dihydroisoquinolinium salts for treating keratin materials, compositions and implementation processes The present invention relates to the use of one or more dihydroisoquinolinium salts for treating keratin materials, in particular keratin fibres, especially human keratin fibres such as the hair. The invention also relates to a process for treating keratin materials using said salts and optionally in the presence of one or more chemical oxidizing agents. A subject of the invention is also a composition for lightening keratin materials, comprising one or more dihydroisoquinolinium salts as defined below and one or more chemical oxidizing agents. | 2022-08-04 |
| 20220241170 | EYELASH COMPOSITIONS CONTAINING SUGAR - The invention relates to an eyelash composition, especially a mascara composition, including more than 5% by weight of the eyelash composition of at least one sugar, as well as to methods of using such compositions. | 2022-08-04 |
| 20220241171 | FRAGRANCE-ENHANCING COMPOSITIONS - Long-lasting fragrance compositions are provided for. The fragrance compositions can include at least one fragrance compound and a glycoside. The glycoside can be selected from a Steviol glycoside, a glucosylated Steviol glycoside, a derivative of a Steviol glycoside, a derivative of a glucosylated Steviol glycoside, or combinations thereof. Also provided for are products including a long-lasting fragrance composition as above. The products can include perfumes, body care products, cosmetics, cleaning and laundry products, and the like. | 2022-08-04 |
| 20220241172 | ORAL CARE GUMMIES - Disclosed herein is an oral care composition, such as a mouthwash, in a form of an elastic solid, such as a gummy. The mouthwash gummy may comprise a therapeutically effective amount of an active agent for treatment of an oral condition and an excipient. Also disclosed herein are methods of preparing and methods of using said oral care composition to, for instance, cleanse a mouth, treat an oral condition, and/or refresh breath. | 2022-08-04 |
| 20220241173 | Skincare Formulation for Multi-Modal Reduction of Acetylcholine Concentration and Activity - A skincare formulation for reducing facial expression lines via multi-modal reduction of ACh concentration and activity. The formulation includes a carrier base, an inhibitory neurotransmitter and a plurality of neuromodulating peptides configured to inhibit ACh concentration and activity at the epidermis as well as at the neuro-muscular junction The inhibitory neurotransmitter is configured to reduce neuronal excitability. The plurality of neuromodulating peptides includes a first neuromodulating peptide configured to compete with SNAP-25 in the SNARE complex of the motor neuron at the presynaptic terminal, a second neuromodulating peptide configured to destabilize the SNARE complex at the presynaptic terminal, a third neuromodulating peptide configured to inhibit fusion of ACh vesicles in neuron plasma membrane, a fourth neuromodulating peptide configured to inhibit contraction of muscles via inhibition of transmitter-gated ion channel communication at the postsynaptic membrane, and a fifth neuromodulating peptide configured to block reception of ACh at the muscle cell, the postsynaptic membrane. | 2022-08-04 |
| 20220241174 | PEPTIDE HAVING ACTIVITY OF IMPROVING SKIN CONDITION AND USE THEREOF - Provided are a peptide having an activity of improving skin condition and use thereof. In particularly, provided are a peptide consisting of an amino acid sequence of SEQ ID NO: 1, a cosmetic composition including the peptide for improving skin condition, and a pharmaceutical composition including the peptide for preventing or treating an inflammatory skin disease. | 2022-08-04 |
| 20220241175 | Skin Care Composition and Method of Using the Same - A skin care composition that contains a combination of a vitamin B | 2022-08-04 |
| 20220241176 | METHOD FOR LOADING OF MICROORGANISMS ON MULTIPHASE BIOMATERIALS - A method for loading one or more microorganisms or parts thereof on and/or in pre-synthesized multiphase biomaterials including nanocellulose wherein the microorganisms are resuspended in a buffer or a culture medium and loaded into and/or onto the multiphase biomaterial. Uses of such loaded multiphase biomaterials may be in nutritional, food, pharmaceutical, medical, cosmetic, especially oral, mucosal, dermal and transdermal, ocular, dermatological, or female health applications. | 2022-08-04 |
| 20220241177 | Clear Nail Top Coat Compositions And Methods Of Making - Clear nail polish top coat formulations prepared without the use of toxic compounds, such as toluene, are provided. The compositions utilize cellulose acetate butyrate (CAB) as a main resin and discussed are the effects of numerous solvents, plasticizers, co-resins, and/or additives on CAB's solubility. For example, the type and ratio of solvents used are related to the selected CAB grade's molar ratio of butyryl, acetyl, and hydroxyl R-groups. Performances measures include, but are not limited to, transmitted haze, reflected haze, hardness, viscosity, shrinkage, tensile strength, and elastic modulus. Additionally, the effect of filtration on the transmitted haze is also discussed. | 2022-08-04 |
| 20220241178 | OXIDATIVE HAIR CREAM COMPOSITION CONTAINING THIOPHENE AZO COLORANT - This invention relates to an oxidative hair cream composition that contains at least one oxidative hair cream ingredient and at least one thiophene azo colorant. | 2022-08-04 |
| 20220241179 | CLEANSING COMPOSITIONS - Shampoo composition including about 6 wt. % or more of one or more betaine surfactants; about 5 wt. % or less of one or more anionic surfactants; about 0.1 wt. % to about 10 wt. % of one or more fatty amine surfactants; about 0.1 to about 15 wt. % of one or more nonionic surfactants, wherein at least one of the one or more nonionic surfactants is selected from alkoxylated fatty alcohols, polyethylene glycol ethers of fatty alcohols, or a mixture thereof; and water, wherein all weight percentages are based on the total weight of the shampoo composition. The shampoo compositions typically have a weight ratio of the total amount of the one or more betaine surfactants to the total amount of the one or more anionic surfactants, the one or more fatty amine surfactants, and the one or more nonionic surfactants that is 0.8:1 to 5:1 and are typically substantially free of anionic sulfate surfactants and silicones. | 2022-08-04 |
| 20220241180 | COMPOSITION COMPRISING SORBITOL OR XYLITOL, AND A GELLING AGENT - A composition includes (i) a sugar alcohol selected from sorbitol, xylitol, and mixtures thereof; (ii) water in an amount of from about 20% to about 60% by weight of the composition; and (iii) a gelling agent. | 2022-08-04 |
| 20220241181 | NOVEL COSMETIC AND DERMATOLOGICAL USES OF AN EXTRACT OF CISTUS MONSPELIENSIS - Novel cosmetic and dermatological uses of an extract of | 2022-08-04 |
| 20220241182 | USES OF WHITE ROSELLE EXTRACT FOR SKIN HYDRATING - A method for enhancing skin moisture of a subject in need thereof includes administering to the subject a composition including a white roselle ( | 2022-08-04 |
| 20220241183 | TOPICAL SKIN CARE FORMULATIONS COMPRISING BOTANICAL EXTRACTS - A method of administering a composition that includes an extract of | 2022-08-04 |
| 20220241184 | GASTRORETENTIVE DOSAGE FORMS OF LEVODOPA AND CARBIDOPA - The present disclosure provides self-regulating, oral, osmotic, floating gastroretentive CD/LD compositions that are suitable for once- or twice-daily administration. The compositions provide extended release with enhanced pharmacokinetic attributes of LD, e.g., reduced lag time, avoidance of low trough levels, and reduced peak-to-trough ratios (C | 2022-08-04 |
| 20220241185 | TOPICAL COSMETIC COMPOSITIONS - A method of reducing the appearance of dark circles in a periorbital area of a person's face is disclosed. The method can include topically applying to the dark circles a composition comprising an extract of | 2022-08-04 |
| 20220241186 | IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF BUPRENORPHINE - The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine. | 2022-08-04 |
| 20220241187 | ADMINISTRATION OF BENZODIAZEPINE COMPOSITIONS - The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions. | 2022-08-04 |
| 20220241188 | METHOD AND SYSTEM FOR MAKING PERSONALIZED NUTRITIONAL AND PHARMACEUTICAL FORMULATIONS USING ADDITIVE MANUFACTURING - The presently disclosed subject matter is directed to a system and method of preparing personalized nutritional and/or pharmaceutical formulations using additive manufacturing technology. Active pharmaceutical or dietary supplement ingredients are suspended in thixotropic stable carrier medias. The thixotropic suspensions are deposited onto a surface of a solid substrate, which can be a snack bar or small wafer used as a mechanical carrier. The disclosed system enables each additive active ingredient to be variably dosed based on a formula that is determined for each specific individual and manufactured on demand. Once the active ingredients are deposited on substrate, the entire assembly can be enrobed with one or more edible solid coatings to seal the active ingredients and provide taste-masking agent characteristics to the assembly. | 2022-08-04 |
| 20220241189 | MODIFIED RELEASE DRUG POWDER COMPOSITION COMPRISING GASTRO-RETENTIVE RAFT FORMING SYSTEMS HAVING TRIGGER PULSE DRUG RELEASE - An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof. | 2022-08-04 |
| 20220241190 | PHARMACEUTICAL COMPOSITION COMPRISING GHB GASTRO-RETENTIVE RAFT FORMING SYSTEMS HAVING TRIGGER PULSE DRUG RELEASE - An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provide. The composition contains, at a minimum, (a) at least one GHB drug in a first pulse release which releases in less than about 3 hours; (b) at least one GHB drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent; and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one GHB drug in the stomach for at least about 3 hours. | 2022-08-04 |
| 20220241191 | METHOD OF TREATING EPILEPSY - Alprazolam formulated as an inhaled condensation aerosol and method for treating epilepsy and/or seizures. | 2022-08-04 |
| 20220241192 | Microemulsion Delivery Systems for Water-Based Beverages - Microemulsion beverages are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. The described microemulsion beverages may be thought of as modified oil-in-water (MOIHW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIHW microemulsion are modified with alcohol and can solubilize oil-soluble species, including cannabis extracts. The polar continuous “water” phase of the MOIHW microemulsion is modified with a sugar or sugar alcohol. | 2022-08-04 |
| 20220241193 | PHARMACEUTICAL COMPOSITIONS IN THE FORM OF GEL CONTAINING XYLOGLUCAN AND ALCOHOLS FOR THE CONTROLLED RELEASE OF ACTIVE INGREDIENTS - The invention relates to gel compositions comprising pharmaceutical active ingredients. The composition comprises xyloglucan at a concentration between 0.1% and 10.0% by total weight of the composition, together with a primary alcohol at a concentration between 20.0 and 50.0% by total weight of the composition. The invention also describes a process for the preparation of the composition and its use in the treatment of pathologies wherein a controlled release of the active principle is useful. | 2022-08-04 |
| 20220241194 | CROSSLINKABLE HYDROGEL COMPOSITIONS - A cross-linkable hydrogel composition comprising an aqueous base carrier composition and a cross-linkable hydrogel precursor, wherein the aqueous base carrier composition comprises one or more polymers and one or more nanoparticles, wherein the one or more polymers are selectively adsorbed to the one or more nanoparticles, and wherein the one or more polymers and the one or more nanoparticles form a shear-thinning and self-healing hydrogel and wherein the one or more polymers and the one or more nanoparticles and cross-linkable hydrogel precursor are each comprised in the cross-linkable hydrogel composition in a concentration at which neither the one or more polymers nor the nanoparticles, taken alone, form a hydrogel, characterized in that the cross-linkable hydrogel precursor is not selectively adsorbed to the one or more nanoparticles and in that the cross-linkable hydrogel precursor and the one or more nanoparticles don't form a transient shear-thinning and self-healing hydrogel. | 2022-08-04 |
| 20220241195 | PHARMACEUTICAL SOLUTION OF AMLODIPINE - Disclosed herein is a liquid pharmaceutical formulation substantially free of water, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin. Also disclosed herein is a liquid pharmaceutical formulation substantially free of water and ethanol, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin. | 2022-08-04 |
| 20220241196 | TRANSDERMAL SOLVENT SYSTEM AND METHODS OF USE - Described herein are transdermal solvent systems comprising at least one active agent in solution in a base solution, the base solution comprising at least one fatty acid ester compound, at least one monoterpene compound and a co-solvent in the form of DMSO or DMI and at least one plant oil. The base solution was found to be highly versatile and provide superior or at least comparable skin penetration efficacy and active agent compatibility. Methods of treatment, uses of the solvent system and methods of manufacture are also described. | 2022-08-04 |
| 20220241197 | SUSPENSIONS AND DILUENTS FOR METRONIDAZOLE AND BACLOFEN - Suspensions of metronidazole or baclofen and/or salts or ester derivative thereof, such as metronidazole benzoate, are disclosed. The suspension my include metronidazole or baclofen, and/or a salt or ester derivative thereof a hydrocolloid stabilizer, simethicone emulsion, a buffer, such as sodium citrate, (dihydrate), a preservative, a thickening agent, a sweetener, and water. | 2022-08-04 |
| 20220241198 | COPOLYMERS FOR STABILIZING EMULSIONS AND/OR FORMING INTERFACIAL FILMS, AND METHODS THEREOF - The present invention generally relates to polymers and, in particular, to copolymers for stabilizing, e.g., emulsions or droplets. In certain aspects, the copolymers may comprise a relatively hydrophobic monomer and a relatively hydrophilic monomer polymerized together (e.g., randomly) to form the copolymer. Examples of hydrophobic monomers include methacrylates and vinylphenyls; examples of hydrophilic monomers include boronic acids or acid derivatives. Surprisingly, such random copolymers may act as surfactants, e.g., stabilizing droplets within the emulsion. In addition, in some cases, an interfacial film may be produced by exposing the copolymer to a complexing molecule, such as a polyol, that can complex with the copolymer to form the film. In some cases, the film may at least partially surround a droplet, and in certain embodiments, the film may be sufficiently sturdy such that the droplet can be removed from the emulsion. Other aspects include methods of making or using such copolymers (for example, for containing cells in droplets), kits involving such copolymers, or the like. | 2022-08-04 |
| 20220241199 | CANNABINOID EMULSION COMPOSITION AND METHOD OF MANUFACTURE - A method for forming an emulsion containing a cannabinoid includes the steps of first providing a composition comprising water, vitamin E TPGS, a cannabinoid, and a carrier oil, in a high pressure container. The composition is initially opaque. The composition is then heated to a temperature between 50-120 degrees Celsius, the heating increasing the pressure in the high pressure container to greater than 1 ATM. The high pressure container is then cooled, while mixing, until the composition turns clear, and a micelle water emulsion is formed with particles under 100 nm in particle size. | 2022-08-04 |
| 20220241200 | COMPOSITIONS AND METHODS FOR SUSTAINED TREATMENT OF PAIN - Disclosed herein is a composition for treating post-surgical pain comprising: an aqueous carrier; and a lipid phase comprising an anesthetic agent, the lipid phase dispersed within the aqueous carrier. In certain aspects, the aqueous carrier is hydrogel comprised of tyramine substituted hyaluronic acid. In certain embodiments, the hydrogel is formed through di-tyramine crosslinking. In certain embodiments, the degree of tyramine substitution of hyaluronic acid hydroxyl groups is about 0.5% to about 3%. In further aspects, the lipid phase is comprised of a plurality of lipid microparticles. According to certain embodiments, a salt form of the anesthetic unbound by the plurality of lipid microparticles is dissolved in the aqueous carrier. | 2022-08-04 |
| 20220241201 | Microemulsion Delivery Systems for Alcohol-Soluble Species Including Nonderivatized Hormones - Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. The described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize alcohol-soluble species, including nonderivatized hormones. The polar continuous “water” phase of the MOIW microemulsion is modified with a sugar or sugar alcohol. | 2022-08-04 |
| 20220241202 | METHOD AND VEHICLE FOR DELIVERING AGENTS ACROSS THE BLOOD-BRAIN BARRIER - The present disclosure relates generally to a method and vehicle for drug delivery. In particular, the present disclosure provides methods for delivering an agent across the blood-brain barrier and an agent delivery vehicle for same. | 2022-08-04 |
| 20220241203 | METHOD FOR PRODUCTION OF LIPOSOMES - The present disclosure relates to a method for production of liposomes, in order to obtain high encapsulation efficiency of encapsulated agents with a reduced number of production steps, namely avoiding the extrusion step of the classical liposomal production process. The liposomes of the invention are intended to carry a therapeutic agent like an anticancer agent, antioxidant, anti-inflammatory, antipyretic, antibiotic, antiviral, antirheumatic, analgesic, growth-factor, or mixtures thereof. | 2022-08-04 |
| 20220241204 | TOPICAL TIME RELEASE DELIVERY USING LAYERED BIOPOLYMER - The instant technology generally relates to a topical (e.g. transdermal) patch for delivery of an active agent. The patch comprises soluble, hydrophilic polycaprolactone (PCL) as a delivery substrate for an active agent of interest. Soluble, hydrophilic PCL can be formulated to adjust the degradation rate of the PCL, in order to deliver the active agent at a desired delivery rate. | 2022-08-04 |
| 20220241205 | Improved Lyophilized Formulations Involving Hyaluronic Acid and Plasmatic Proteins, and Uses Thereof - The invention concerns lyophilized pharmaceutical formulations comprising plasmatic proteins or derivatives thereof, hyaluronic acid or a derivative thereof, and optionally one or more other pharmaceutically active ingredients, such as clonidine or a derivative thereof, wherein the lyophilized pharmaceutical formulations are characterized by a reconstitution time of less than 15 minutes. The invention further relates to methods for preparing these formulations, and their use for treating musculoskeletal diseases such as bone or joint diseases. | 2022-08-04 |
| 20220241206 | PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition. | 2022-08-04 |
| 20220241207 | EXTENDED-RELEASE SOLID ORAL DOSAGE FORM COMPRISING VITAMIN B12 AND A VITAMIN B12 DEPLETING DRUG - The present invention relates to a solid oral dosage form comprising an extended-release tablet core that is coated with an immediate-release coating, wherein said extended-release tablet core comprises at least one vitamin B12 depleting drug, and wherein said immediate-release coating comprises vitamin B12 or a spray dried formulation thereof. In a preferred embodiment, the vitamin B12 depleting drug is metformin or a pharmaceutically acceptable salt thereof. | 2022-08-04 |
| 20220241208 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HBV - The present disclosure provides, in part, pharmaceutical compositions that comprise a spray dried dispersion which contains the disclosed compound, and optionally, pharmaceutical excipients. The pharmaceutical compositions of the disclosure may be used in the treatment of Hepatitis B (HBV). | 2022-08-04 |
| 20220241209 | SYNTHETIC PROGESTOGENS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME - Described herein are synthetic progestogens, such as 6β,7β:15β,16β-Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, as well as pharmaceutical compositions comprising the same. Also described are methods of use. | 2022-08-04 |
| 20220241210 | Polyvalent Dosage Forms and Method For Their Production - The present invention relates to solid or semi-solid dosage forms made of solidified filament structures having different compositions. At least some of the filament structures contain at least one pharmaceutical active agent, nutraceutical active agent and/or dietary supplemental active agent. Other filament structures of the dosage forms can contain the same active agent e.g., in different concentrations, a different active agent, or no active agent. The invention also relates to a method for 3D printing of the dosage forms. | 2022-08-04 |
| 20220241211 | COMPOSITION CONTAINING MICROCAPSULE AND CELL STRUCTURE - An object of the present invention is to provide a composition containing at least microcapsules and cell structures, where the composition can exhibit a high treatment effect in a case of being transplanted into a living body. There is provided a composition including at least (a) a microcapsule containing a polymer hydrogel; and (b) a cell structure containing a biocompatible polymer block and a cell, in which a plurality of biocompatible polymer blocks are arranged in gaps between a plurality of cells, where at least a part of the cell structures are encapsulated in the microcapsules. | 2022-08-04 |
| 20220241212 | CARIPRAZINE RELEASE FORMULATIONS - The patent discloses long-term injectable formulations and delivery systems of cariprazine and related salts and derivatives in the prevention and treatment of various psychotic diseases, such as schizophrenia, mania, and bipolar disorder. The dosage forms are either microsphere, microparticle, nanoparticle drug delivery systems in a pharmaceutically acceptable carrier, or devices that contain long-term injectable formulation of such cariprazine and related salts and derivatives. | 2022-08-04 |
| 20220241213 | DELAYED AND SUSTAINED DELIVERY OF ANTICANCER DRUGS - The present invention relates to an anti-cancer delivery system with a delayed and sustained release of one or more chemotherapeutic agent(s), a mixture for use in the treatment of cancer comprising such a delivery system and a method for producing such a delivery system. | 2022-08-04 |
| 20220241214 | NANOPARTICLES COMPRISING QUINONE W METHIDES AND COMPOSITIONS FOR USE - A nanoparticle comprising one or more quinonemethide triterpenoids or one or more inhibitors of metadherin, and methods of using the nanoparticles, are provided. | 2022-08-04 |
| 20220241215 | TRANSDERMAL THERAPEUTIC SYSTEM COMPRISING AN ACTIVE AGENT-CONTAINING LAYER COMPRISING A SILICONE-CONTAINING POLYMER AND A SKIN CONTACT LAYER COMPRISING A SILICONE GEL ADHESIVE - The present invention relates to a transdermal therapeutic system for the transdermal administration of an active agent comprising an active agent-containing layer structure, said active agent- containing layer structure comprising: A) a backing layer; B) an active agent-containing layer comprising at least one silicone-containing polymer; C) a skin contact layer; and wherein the skin contact layer is an adhesive layer comprising a silicone gel adhesive. | 2022-08-04 |
| 20220241216 | TRANSDERMAL THERAPEUTIC SYSTEM COMPRISING AN ACTIVE AGENT-CONTAINING LAYER COMPRISING AN ACRYLIC POLYMER AND A SKIN CONTACT LAYER COMPRISING A SILICONE GEL ADHESIVE - The present invention relates to a transdermal therapeutic system for the transdermal administration of an active agent comprising an active agent-containing layer structure, said active agent-containing layer structure comprising: A) a backing layer; B) an active agent-containing layer comprising at least one acrylic polymer; C) a skin contact layer; and wherein the skin contact layer is an adhesive layer comprising a silicone gel adhesive. | 2022-08-04 |
| 20220241217 | COMPOSITIONS FOR THE DELIVERY OF THERAPEUTIC AGENTS AND METHODS OF USE AND MAKING THEREOF - Some embodiments pertain to nanoparticle-based compositions and their use in methods for the delivery of CBD to subjects. In some embodiments, the compositions are stable for prolonged periods of time and provide enhanced bioavailability. | 2022-08-04 |
| 20220241218 | TRANSDERMAL THERAPEUTIC SYSTEM - The present invention concerns a transdermal therapeutic system, comprising a backing layer, which is not permeable for the active ingredient, and a matrix layer on one side of the backing layer, wherein the matrix layer contains at least one pressure sensitive adhesive and ketamine or a pharmaceutically acceptable salt or solvate thereof, wherein the at least one pressure sensitive adhesive has free hydroxyl groups, as well as its use as medicament, in particular for the treatment of depression and pain. | 2022-08-04 |
| 20220241219 | SUPRAMOLECULAR HYDROGEL APPLICATIONS TO THE CAROTID BODIES TO TREAT HYPERTENSION AND SLEEP APNEA IN OBESITY - The present invention provides compositions and methods for treating hypertension and obstructive sleep apnea utilizing hydrogel compositions comprising drug amphiphiles with TRPM 7 antagonists for use in a subject, including use on the carotid body of a subject. | 2022-08-04 |
| 20220241220 | BUPROPION AS A MODULATOR OF DRUG ACTIVITY - Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan. | 2022-08-04 |
| 20220241221 | BUPROPION AS A MODULATOR OF DRUG ACTIVITY - Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan. | 2022-08-04 |
| 20220241222 | ATOMOXETINE HYDROCHLORIDE EXTENDED RELEASE COMPOSITIONS AND METHODS OF USE - This disclosure provides pharmaceutical compositions comprising atomoxetine, a pharmaceutically acceptable salt of atomoxetine, or a combination thereof, that can be administered to a human subject in need thereof. The disclosure also provides pharmaceutical compositions for the treatment of orthostatic hypotension. | 2022-08-04 |
| 20220241223 | USE OF DISULFIRAM OR ITS DERIVATIVES FOR THE TREATMENT OF MITOCHONDRIAL DISEASES OR DYSFUNCTION - The present invention relates to the use of disulfiram or one of its derivatives for use in the treatment of a mitochondrial dysfunction or diseases, advantageously of a genetic mitochondrial disease. | 2022-08-04 |
| 20220241224 | Conditioning Irradiated Tissue for Increasing Vascularity - Methods of increasing perfusion and vascularity in irradiated tissue and of increasing retention of fat cells in a fat graft in irradiated tissue by applying an effective amount of DFO to the irradiated tissue at a treatment site. The DFO may be administered transdermally. | 2022-08-04 |
| 20220241225 | SOTALOL HYDROCHLORIDE DOSING - The present invention provides novel methods of administering sotalol hydrochloride to patients in need thereof. | 2022-08-04 |
| 20220241226 | Method of Treating Colorectal Cancers Using a PKC Inhibitor - The subject invention pertains to methods of treating colorectal cancer by administering an atypical PKC inhibitor. The inhibitors of aPKC useful in the methods of the instant invention include ACPD, ICA-1, DNDA and ζ-Stat. Also provided are methods of measuring the susceptibility of colon cancer cells of a subject to inhibitors of aPKCs. | 2022-08-04 |
| 20220241227 | COMPOSITIONS COMPRISING HDAC INHIBITORS AND RETINOIDS - The present invention provides compositions and methods comprising conjugates with a polymeric backbone, e.g., polyvinyl alcohol (PVA), covalently linked histone deacetylase (HDAC) inhibitors, such as butyrate or propionate, and covalently linked retinoids, such as all-trans retinoic acid (RA). The methods and compositions of the invention are useful for the treatment or prevention of cancer or metabolic diseases in tissues such as the colon or liver. | 2022-08-04 |
| 20220241228 | Treatment of cholangiopathies - Seladelpar and its salts are useful in the treatment of cholangiopathies in subjects who are intolerant of, or have an inadequate response to, obeticholic acid and/or fibrates. | 2022-08-04 |
