31st week of 2022 patent applcation highlights part 29 |
Patent application number | Title | Published |
20220243234 | ENRICHMENT OF AMINO ACIDS FROM BIOMASS RESIDUUM - The present invention relates to methods of providing a biomass residuum and compositions thereof. In particular examples, the biomass residuum includes one or more high value amino acids, even after removal of mixed alcohol components. In particular, the methods include implementing pre-treatment conditions and employing fermentation conditions including modified organisms. | 2022-08-04 |
20220243235 | METHOD FOR PRODUCING CYSTEINE FROM GLUTATHIONE - It is an object of the present invention to provide a practical means of producing cysteine from glutathione that is also suitable for use in the field of foods. Cysteine is produced from glutathione by a first step of producing cysteinylglycine by the action of a γ-glutamyl peptidase derived from a microorganism on reduced glutathione; and a second step of producing cysteine by the action of an acid protease derived from a microorganism on the cysteinylglycine. | 2022-08-04 |
20220243236 | PRODUCTION OF CANNABINOIDS USING GENETICALLY ENGINEERED PHOTOSYNTHETIC MICROORGANISMS - The present invention provides methods and compositions for producing cannabinoids in photosynthetic microorganisms, e.g., cyanobacteria. | 2022-08-04 |
20220243237 | SIALYLTRANSFERASES AND USES THEREOF - Provided herein, inter alia, are methods, bacteria, nucleic acids, and polypeptides for producing sialylated oligosaccharides. | 2022-08-04 |
20220243238 | METHOD FOR PREPARING V-TYPE GRANULAR POROUS STARCH - A method for preparing V-type granular porous starch includes the following steps: mixing starch and an ethanol aqueous solution in a temperature of 100-150° C. to yield V-type granular starch; and adding a mixed enzyme including alpha-amylase and amyloglucosidase to a mixture of the V-type granular starch and the ethanol aqueous solution, to enzymatically hydrolyze the V-type granular starch to yield V-type granular porous starch. | 2022-08-04 |
20220243239 | METHOD FOR SYNTHESIZING LACTO-N-BIOSE - A method for synthesizing lacto-N-biose and belongs to the technical field of bioengineering and oligosaccharide synthesis. A multi-enzyme catalytic system with good biological safety and wide application, and an ATP regeneration cycle system is introduced into a multi-enzyme reaction system, so that the synthesis of lacto-N-biose and the utilization rate of substrates are improved. A novel lacto-N-biose synthetic route lays a foundation for large-scale industrial production of lacto-N-biose and has important economic values and social benefits. At the same time, the synthetic method is efficient, mild, simple, easy to operate, low in cost and suitable for industrial production, and has a high practical application value. | 2022-08-04 |
20220243240 | ANALYSIS OF NUCLEIC ACIDS ASSOCIATED WITH SINGLE CELLS USING NUCLEIC ACID BARCODE - Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest. | 2022-08-04 |
20220243241 | Co-Culture of Myxobacteria and Pseudomonas for Enhanced Production of Biosurfactants and Other Metabolites - Methods are provided for enhanced production of microbial biosurfactants, the methods comprising co-cultivating | 2022-08-04 |
20220243242 | METHOD FOR ENHANCING PRODUCTION OF HOMEOPROTEIN USING INHIBITOR OF LYSOSOMAL FUNCTION - A composition for enhancing the production of a homeoprotein includes an inhibitor of lysosomal function. A method for enhancing the production of a homeoprotein, includes treating cells with an inhibitor of lysosomal function, a method for producing an animal cell line continuously expressing a homeoprotein and a method for mass-producing a homeoprotein using the animal cell line. | 2022-08-04 |
20220243243 | EXPRESSION OF PRODUCTS FROM NUCLEIC ACID CONCATEMERS - Provided are techniques for generating expression products using one or more nucleic acid concatemers that include tandem repeats of a nucleic acid sequence encoding the expression product or products. In one embodiment, different expression products may be co-expressed using a concatemer mixture of a first nucleic acid concatemer and a second nucleic acid concatemer having a predefined ratio to one another. | 2022-08-04 |
20220243244 | COMPOSITIONS AND METHODS FOR IN VIVO SYNTHESIS OF UNNATURAL POLYPEPTIDES - Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell. | 2022-08-04 |
20220243245 | BIOSENSOR - A biosensor according to an embodiment of the present invention includes a substrate, a working electrode disposed on the substrate, and a reference electrode disposed on the substrate to be spaced apart from the working electrode. The working electrode includes a sensing electrode disposed on a top surface of the substrate, an enzyme reaction layer disposed on a top surface of the sensing electrode, and a permeation control layer disposed on a top surface of the enzyme reaction layer, and the permeation control layer includes a water-soluble polymer and a water-insoluble polymer. The permeation layer includes a mixture of the water-soluble polymer and the water-insoluble polymer to improve a sensing performance for a sensing target material. | 2022-08-04 |
20220243246 | RAPID ANTIMICROBIAL SUSCEPTIBILITY TESTING BY VIDEO-BASED OBJECT SCATTERING INTENSITY DETECTION - Provided herein are methods of assessing the presence of microbes in a liquid sample that include assessing an initial integrated scattering intensity of objects (I | 2022-08-04 |
20220243247 | VAGINAL MICROBIOME MARKERS FOR PREDICTION OF PREVENTION OF PRETERM BIRTH AND OTHER ADVERSE PREGNANCY OUTCOMES - A method for determining the risk of an adverse pregnancy outcome for a woman is provided comprising the steps of measuring a level of TM7-H1 and optionally one or more of BVAB1, | 2022-08-04 |
20220243248 | METHOD FOR THE RAPID DETERMINATION OF SUSCEPTIBILITY OR RESISTANCE OF BACTERIA TO ANTIBIOTICS - A method of rapidly evaluating the susceptibility of a strain of bacteria to a cell wall synthesis inhibiting antibiotic based on an assessment of cell enlargement in response to doses of the cell wall synthesis inhibiting antibiotic which are correlated to breakpoints of bacterial susceptibility. | 2022-08-04 |
20220243249 | ANTAGONISTS OF CAMKII-DELTA 9 AND USES THEREOF - Provided are methods of treating or preventing Ca | 2022-08-04 |
20220243250 | DETERMINATION OF INTERFERENTS IN A SAMPLE - A method for determining a non-anticoagulant interferent in a blood-derived sample of a subject, the method comprising a) determining a value of a coagulation time-related parameter in the sample; b) comparing the value of the coagulation time-related parameter determined in a) to a value of the coagulation time-related parameter determined in at least one reference sample; and c) based on the result of comparison step b), determining the non-anticoagulant interferent in a blood-derived sample of a subject. A method for identifying a blood-derived sample having insufficient quality is further disclosed, the method comprising determining non-anticoagulant interferent(s) according to the aforesaid method. | 2022-08-04 |
20220243251 | NUCLEOTIDES WITH ISOTOPES FOR DNA DATA STORAGE - Nucleotides are provided with at least one isotope. The isotope-modified nucleotides can be used for data storage, increasing the data density compared to only natural nucleotides. Described is a method of storing data on a DNA strand, the method comprising providing a DNA strand having at least one isotope-modified nucleotide comprising at least one isotope of carbon, nitrogen, oxygen or hydrogen, assigning a bit pattern to the at least one isotope-modified nucleotide that is different than a bit pattern assigned to a non-isotope-modified nucleotide. Data could be stored on any molecule that can be isotope-modified. | 2022-08-04 |
20220243252 | ISOTOPE MODIFIED NUCLEOTIDES FOR DNA DATA STORAGE - Methods of encoding data in a DNA strand or an RNA strand. In one method, a first nucleotide has a first bit pattern assigned thereto, and a second modified nucleotide has a second bit pattern assigned thereto different than the first bit pattern. The second modified nucleotide is different from the first nucleotide in that the second nucleotide is either isotope-modified, comprising at least one isotope of one of carbon, nitrogen, oxygen or hydrogen, or otherwise-modified, such as with a different atom in a cyclic position or with a ligated metal ion or atom. Data, in the form of bits, can be stored on any molecule that can be isotope- or otherwise modified. | 2022-08-04 |
20220243253 | METHODS OF DETERMINING DNA BARCODES FOR EFFICIENT SPECIES CATEGORIZATION USING NANOPORE TRANSLOCATION - Methods of accurately determining DNA barcodes using a cylindrical nanopore system. The methods include steps of leveraging the average velocity of a double-stranded DNA segment passing through a single cylindrical nanopore that is measured through repeated scanning to accurately determine protein tag locations on the double-stranded DNA segment. As such, the methods provide for the accurate calculation of a barcode for the double-stranded DNA segment based on protein tag locations without underestimation or overestimate issues. The underlying concept and the methods are equally applicable to other multi-nanopore systems which use the dwell time and time of flight velocities to measure the barcodes. | 2022-08-04 |
20220243254 | METHODS AND SYSTEMS FOR NUCLEIC ACID ANALYSIS AND QUANTIFICATION - The present disclose provides methods and systems for amplifying and quantifying nucleic acids and for detecting the presence or absence of a target in a sample. The methods and systems provided herein may utilize a device comprising a plurality of partitions separated from an external environment by a gas-permeable barrier. Certain methods disclosed herein involve subjecting nucleic acid molecules in the plurality of partitions to conditions sufficient to conduct nucleic acid amplification reactions. The nucleic acid molecules may be subjected to controlled heating in the plurality of partitions to generate data indicative of a melting point(s) of the nucleic acid molecules. | 2022-08-04 |
20220243255 | MOLECULAR GLUE SCREENING ASSAYS AND METHODS FOR PRACTICING SAME - The present disclosure provides a compound screening method comprising screening a test compound that binds a target protein of interest and another ligand protein that is not previously known to form a complex, comprising, (i) in the presence and absence of a test compound, incubating an immobilized ligand protein with a target protein of interest, comprising a nucleic acid tag, wherein the protein of interest and the nucleic acid tag differ from each other; (ii) removing unbound target protein of interest; and (iii) detecting the presence or absence of complex between the immobilized ligand protein, test compound, and the target protein of interest, wherein an increase in the amount of target protein of interest bound to the immobilized ligand protein in the presence of test compound as compared to the absence of test compound indicates the test compound binds to and enables protein-protein complex formation between the immobilized ligand protein and the target protein of interest. | 2022-08-04 |
20220243256 | Thermocycling PCR chip made of transparent graphene conductive film - In the present invention, graphene Transparent Conductive Film (TCF) is integrated into a disposable PCR chip in which PCR reaction containers are sandwiched by two graphene TCFs. PCR is performed by thermocycling of the on-chip two graphene TCF simultaneously. A temperature sensor in the PCR chip is to measure the chip temperature in a real-time manner during PCR reaction, and to provide a feedback to control the thermocycling of the graphene TCF. | 2022-08-04 |
20220243257 | SYSTEM AND METHOD FOR GENERATING A PERSONALIZED PREDICTED PROTEOME - A process for predicting a proteome based on one or more tissue samples of an individual may include: (a) identifying somatic and germline variants based on a reference genome and nucleotide sequences derived from the tissue samples; (b) constructing a customized genome by modifying the reference genome based on the somatic and germline variants identified; (c) aligning RNA sequences derived from the tissue samples to the customized genome; (d) assembling a detected transcriptome with transcripts derived from the aligned RNA sequences; and € associating the detected transcriptome with proteins in a protein database and including the associated proteins in the proteome. The tissue samples includes a tissue sample obtained from a diseased site (“target sample”) and a matched normal or virtual normal tissue sample. | 2022-08-04 |
20220243258 | Methods Relating to Tuberculosis - The invention relates to a method of diagnosis of tuberculosis (TB) disease in a subject. The method comprises admixing a Mycobacteria-specific bacteriophage with a sample of peripheral blood mononuclear cells (PBMCs) from the subject, followed by determination of the presence or absence of a Mycobacterial DNA sequence in DNA isolated from the admixture. The invention provides a sensitive and specific test for the presence of incipient TB, i.e. an asymptomatic infection with a high risk of developing active TB, or for the presence of latent tuberculosis infection (LTBI), i.e. an asymptomatic infection that is not likely to develop into active TB, in a subject. | 2022-08-04 |
20220243259 | DETERMINING THE DNA PRESENT IN A CELL BY IMAGING AND MATCHED FILTERING - Disclosed herein are systems and methods for evaluating segments of DNA within a single strand or chromosome using matched filtering. DNA within a cell of interest, such as a gamete or embryonic cell, may be imaged at high resolution to provide an input signal. Matched filters may be created for reference signals from reference samples of cells having homologous chromosomes that share the same haplotypes as the DNA within the cell of interest. By applying a matched filter for a given haplotype to the input signal it can be determined whether the DNA within the cell of interest shares the same haplotype as the reference sample. The nucleotide sequence of one or more segments of DNA from the cell of interest may be reconstructed by identifying the haplotypes present in the DNA. | 2022-08-04 |
20220243260 | METHOD AND INSTRUMENTATION FOR SPATIAL MULTIOMICS USING SUMI-TECHNOLOGY - Microscopy imaging that allow for multiple mRNAs, proteins and metabolites to be spatially resolved at a subcellular level provides valuable molecular information which is a crucial factor for understanding tissue heterogeneity as for example within the tumor micro environment. The current invention describes a method (SUMI-Seq) which combines the use of Spatial Unique Molecular Identifier in situ sequencing and in vitro sequencing of rolonies derived from rolling circle amplification from padlock oligonucleotides targeting portion of RNA or cDNA transcript at a subcellular level with less limitation in the amount of transcripts and the length of the sequence that can be analyzed. Apart from padlocks oligonucleotides, the SUMI-Seq method can also be applied using circular oligonucleotides to spatially resolve proteins and metabolites to provide multiomics results. | 2022-08-04 |
20220243261 | KINETIC EXCLUSION AMPLIFICATION OF NUCLEIC ACID LIBRARIES - A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated. | 2022-08-04 |
20220243262 | COMPOSITIONS AND METHODS FOR QUANTIFYING A NUCLEIC ACID SEQUENCE IN A SAMPLE - The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction. | 2022-08-04 |
20220243263 | MARKERS FOR IDENTIFYING AND QUANTIFYING OF NUCLEIC ACID SEQUENCE MUTATION, EXPRESSION, SPLICE VARIANT, TRANSLOCATION, COPY NUMBER, OR METHYLATION CHANGES - The present invention relates to methods for identifying and/or quantifying low abundance, nucleotide base mutations, insertions, deletions, translocations, splice variants, miRNA variants, alternative transcripts, alternative start sites, alternative coding sequences, alternative non-coding sequences, alternative splicings, exon insertions, exon deletions, intron insertions, or other rearrangement at the genome level and/or methylated nucleotide bases. | 2022-08-04 |
20220243264 | SYSTEMS AND METHODS FOR AMPLIFYING RNA - Described in certain example embodiments herein are highly sensitive systems and methods of amplifying RNA in a sample. In certain example embodiments, the method includes reverse transcribing one or more strands of template RNA in the sample into a first cDNA strand in the presence of a first primer comprising a unique molecular identifier (UMI), a second primer comprising a T7 promoter sequence, and a reverse transcriptase enzyme; synthesizing a second cDNA strand in the presence of a DNA polymerase to generate double-stranded cDNA; and transcribing the double-stranded cDNA in the presence of a T7 RNA polymerase to generate amplified RNA. The systems and methods described herein allow for amplification from very small amounts of template RNA, in some embodiments, as little as 0.5 picograms. | 2022-08-04 |
20220243265 | PULSED LASER AND BIOANALYTIC SYSTEM - Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument. | 2022-08-04 |
20220243266 | METHODS AND DEVICES FOR AMPLIFICATION OF NUCLEIC ACID - The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions. In a preferred embodiment, a plurality of groups of amplified product are generated on the surface, each group positioned in different (typically predetermined) locations on said surface so as to create an array. | 2022-08-04 |
20220243267 | COMPOSITIONS AND METHODS RELATED TO QUANTITATIVE REDUCED REPRESENTATION SEQUENCING - The present disclosure provides compositions and methods pertaining to a next-generation sequencing (NGS) library preparation protocol and method for the optimization of sequencing quality and yield. In particular, the present disclosure provides a novel sequencing platform referred to as OmeSeq, which enables high-fidelity, dosage-sensitive genotyping and strain-level metagenomic profiling of various DNA and RNA templates across animal, plant, microbial, and viral genomes. | 2022-08-04 |
20220243268 | METHODS OF SEQUENCING COMPLEMENTARY POLYNUCLEOTIDES - Disclosed herein, inter alia, are complexes, kits, and efficient methods of sequencing two strands of a double stranded polynucleotide. | 2022-08-04 |
20220243269 | SPATIAL INDEXING OF GENETIC MATERIAL AND LIBRARY PREPARATION USING HYDROGEL BEADS AND FLOW CELLS - Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided. The spatial segregation can be used to index sequence reads from individual sequencing libraries to increase efficiency of subsequent data analysis. In some examples, hydrogel beads containing encapsulated sequencing libraries are captured on a sequencing flow cell and degraded in the presence of a liquid diffusion barrier to allow for the spatial segregation and seeding of the sequencing libraries on the surface of the flow cell. Additionally, examples of systems, methods and compositions are provided relating to flow cell devices configured for nucleic acid library preparation and single cell sequencing. Some examples include flow cell devices having a hydrogel with genetic material disposed therein, and which is retained within the hydrogel during nucleic acid processing. | 2022-08-04 |
20220243270 | APPLICATION OF CIRCULAR RNA IN PREPARING DRUG FOR TREATING SYSTEMIC LUPUS ERYTHEMATOSUS - The present invention provides use of a circular RNA with an incomplete double-stranded structure of 16 bp-33 bp in length and/or a promoting agent of the circular RNA with an incomplete double-stranded structure of 16 bp-33 bp in length in preparation of a medicament for treating systemic lupus erythematosus. | 2022-08-04 |
20220243271 | ASSESSING RISK OF READING AND LANGUAGE IMPAIRMENT - Described herein are the association BV677278 (READ1) with reading disability and language impairment, as well as the synergistic interaction of DCDC2 risk haplotypes or alleles with KIAA0319 risk allele. | 2022-08-04 |
20220243272 | BIOMARKER IDENTIFICATION - Disclosed are method and apparatus for identifying biomarkers and in particular for identifying biomarkers for use in making clinical assessments, such as early diagnostic, diagnostic, disease stage, disease severity, disease subtype, response to therapy or prognostic assessments. In one particular example, the techniques are applied to allow assessments of patients suffering from, suspected or suffering from, or with clinical signs of SIRS (Systemic Inflammatory Response Syndrome) being either infection-negative SIRS or infection-positive SIRS. | 2022-08-04 |
20220243273 | BLOOD RNA BIOMARKERS OF CORONARY ARTERY DISEASE - The present invention discloses a unique panel of gene transcripts down-regulated in patients with coronary artery disease (CAD). Methods and compositions for detecting CAD in patient blood samples are provided. | 2022-08-04 |
20220243274 | METHOD FOR PREDICTING RESPONSE TO ANTICANCER IMMUNOTHERAPY USING DNA METHYLATION ABERRATION - Disclosed is a method for providing information for predicting a response to cancer treatment, the method including: obtaining information on a global DNA methylation level detected from a sample of a cancer patient; and evaluating a response to cancer treatment based on the information on the global DNA methylation level. | 2022-08-04 |
20220243275 | GENES AND GENE SIGNATURE FOR DIAGNOSIS AND TREATMENT OF MELANOMA - Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma. | 2022-08-04 |
20220243276 | METHODS OF DETECTING CANCER - Methods and compositions involving molecular markers for the detection and characterization of cancer in a patient are provided. | 2022-08-04 |
20220243277 | METHODS AND NUCLEIC ACIDS FOR DETERMINING THE PROGNOSIS OF A CANCER SUBJECT - The invention provides methods, nucleic acids and kits for determining the prognosis of a subject having cancer. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients. | 2022-08-04 |
20220243278 | DETECTING THE PRESENCE OR ABSENCE OF MULTIPLE TYPES OF CANCER - Provided herein is technology for screening multiple types of cancer from a biological sample, and particularly, but not exclusively, to methods, compositions, and related uses for simultaneously detecting the presence of multiple types of cancer (e.g., liver cancer, esophageal cancer, lung cancer, ovarian cancer, pancreatic cancer, gastric cancer, bladder cancer, breast cancer, cervical cancer, colorectal cancer, prostate cancer, renal cancer, and uterine cancer) from a biological sample (e.g., stool sample, tissue sample, organ secretion sample, CSF sample, saliva sample, blood sample, plasma sample or urine sample). | 2022-08-04 |
20220243279 | SYSTEMS AND METHODS FOR EVALUATING TUMOR FRACTION - Disclosed herein are, at least in part, methods of determining a tumor fraction of a sample from a subject. The methods can include, for example, acquiring a value for a target variable associated with a subgenomic interval in the sample; determining, from the target variable, a certainty metric; accessing a determined relationship between a stored certainty metric and a stored tumor fraction; and determining, with reference to the certainty metric and the determined relationship, the tumor fraction of the sample. | 2022-08-04 |
20220243280 | NTRK FUSION MOLECULES AND USES THEREOF - NTRK fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing, and/or treating a subject having a cancer are disclosed. | 2022-08-04 |
20220243281 | COMPOSITIONS AND METHODS FOR PRESERVING DNA METHYLATION - The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions. | 2022-08-04 |
20220243282 | Compositions and Methods for Monitoring, Diagnosis, Detection and Treatment of Cancer - The present invention relates to the use of compositions for monitoring, diagnosis, detecting, and treating a cancer condition in a subject. The use of composition comprises methods of monitoring, diagnosis, and detecting cancer and inflammation with EN2 and/or SATB2 expression and/or activity. The pharmaceutical composition will further comprise agents that inhibit EN2 and/or SATB2 expression or activity. | 2022-08-04 |
20220243283 | METHODS FOR TYPING OF LUNG CANCER - Methods and compositions are provided for the molecular subtyping of lung cancer samples. Specifically, a method of assessing whether a patient's adenocarcinoma lung cancer subtype is terminal respiratory unit (TRU), proximal inflammatory (PI), or proximal proliferative (PP) is provided herein. The method entails detecting the levels of the classifier biomarkers of Table 1-Table 6 or a subset thereof at the nucleic acid level, in a lung cancer sample obtained from the patient. Based in part on the levels of the classifier biomarkers, the lung cancer sample is classified as a TRU, PI, or PP sample. | 2022-08-04 |
20220243284 | SYSTEMS AND METHODS FOR QUALITY CONTROL IN SINGLE CELL PROCESSING - Provided are systems and methods for analyzing a single cell application or experiment. A set of control beads may be introduced to a biological sample and subjected to the single cell application. The control beads may be configured to mimic analytes in the biological sample, such as a cell or other analyte, and comprise one or more known sequences. The one or more known sequences may be identified to analyze the single cell application. | 2022-08-04 |
20220243285 | COMPOSITIONS AND METHODS FOR DETECTING PLASMODIUM SPECIES NUCLEIC ACID - Disclosed are nucleic acid oligomers, including amplification oligomers, detection probes, and capture probes, for detection of | 2022-08-04 |
20220243286 | MOLECULAR MARKER, GENE OF MAIZE EAR ROT RESISTANCE AND USE THEREOF - The disclosure belongs to the technical field of functional molecular marker, and discloses a molecular marker of maize ear rot resistance, gene and use thereof. In the disclosure a major gene zmSRR1 of maize ear rot resistance is cloned, and the gene's resistance to | 2022-08-04 |
20220243287 | DROUGHT TOLERANCE IN CORN - The present invention relates to a QTL allele in maize associated with drought resistance and carbon isotope composition as well as specific marker alleles associated with the QTL allele. The present invention further relates methods for identifying maize plants based on screening for the presence of the QTL allele or marker alleles. The invention also relates to methods for modifying drought resistance and carbon isotope composition in maize plants. | 2022-08-04 |
20220243288 | BIOSENSORS FOR POLYKETIDE EXTENDER UNITS AND USES THEREOF - The present disclosure relates to biosensors and uses thereof for detecting polyketide extender units. Disclosed herein are biosensor systems and methods for detecting polyketide synthase extender units. In some aspects, disclosed herein is a biosensor system comprising: a first nucleic acid comprising a genetically modified fapR gene, wherein the nucleic acid comprises at least one genetic mutation when compared to the wild-type fapR gene, and wherein the first nucleic acid is operably linked to a first promoter; and a second nucleic acid comprising a reporter gene whose transcription is under the control of a second promoter which is regulated by the fapR transcription factor. | 2022-08-04 |
20220243289 | INFECTIOUS DISEASE SCREENING DEVICE - A disease screening device ( | 2022-08-04 |
20220243290 | MOLECULAR DETECTION OF NOVEL CORONAVIRUSES - Systems for sensitive and accurate detection of sarbecoviruses in samples from human sputum have been established. The systems can rapidly and effectively diagnose patients having suspected coronavirus infections. The systems employ Reverse-Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) to identify and quantify nucleic acids specific to sarbecoviruses within samples from human patients. The systems identify viral RNAs specific for the N and ORF1 genes using a two-step real-time PCR and the SYBR Green detection method. Compositions and methods for reproducibly detecting and quantifying concentrations of sarbecoviruses with a dynamic range of at least seven orders of magnitude (2×10 | 2022-08-04 |
20220243291 | Adeno-Associated Virus Virions with Variant Capsid and Methods of Use Thereof - The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease. | 2022-08-04 |
20220243292 | METHOD OF MANUFACTURING LEATHER - The present invention provides a method of manufacturing leather, which not only significantly suppresses the occurrence of adhesive wrinkling and boarding/alighting wrinkling when used for an automobile seat, for example, but also exhibits appropriate flexibility. | 2022-08-04 |
20220243293 | ELECTROLYTIC SMELTING SYSTEM - An electrolytic smelting system includes: an electrolytic smelting furnace including a furnace body to which a molten ore is introduced, a cathode substrate which is installed on a bottom portion in the furnace body, and an anode substrate which is positioned above the cathode substrate in the furnace body; an inert gas circulation unit including a circulation line to recover an inert gas supplied into the electrolytic smelting furnace together with oxygen and supply the inert gas to the molten ore; and an oxygen-removing unit which is installed in the circulation line and which removes oxygen from the circulation line. | 2022-08-04 |
20220243294 | ADDITIVE FOR TREATING MOLTEN IRON TO PRODUCE CAST IRON WITH ZERO CONTRACTION AND WITH LONSDALEITE-TYPE SPHEROIDAL GRAPHITE - Additive for the thermochemical treatment of molten iron in order to separate, distribute, agglomerate, precipitate, spheroidize and/or crystallize combined, solvated and/or colloidal carbon present in molten iron in the liquid state into graphite in its hexagonal diamond or Lonsdaleite form, in order to produce ductile, nodular, spheroidal, vermicular, coral, spheroidized or grey iron with superior mechanical properties, iron with high metal yield and zero contraction during casting; the additive comprises two or more elements in the metallic state selected from the S-block of periods 2 to 7 of the periodic table of elements; and two or more elements in the metallic state selected from F-block of periods 6 to 7 of the periodic table of elements. The additive makes it possible to produce cast iron parts with Type I and II spheroidal graphite in hexagonal diamond or Lonsdaleite form as per the ASTM-A247 standard. | 2022-08-04 |
20220243295 | HIGH STRENGTH STEEL FOR STRUCTURE WITH EXCELLENT CORROSION RESISTANCE AND MANUFACTURING METHOD FOR SAME - One aspect of the present invention may provide steel having high strength characteristics and excellent corrosion resistance, which is suitable for a structure, and a method for manufacturing same. | 2022-08-04 |
20220243296 | Martensitic Wear Resistant Alloy Strengthened Through Aluminum Nitrides - An iron-based alloy includes, in weight percent, carbon from about 0.75 to about 2 percent; manganese from about 0.1 to about 1 percent; silicon from about 0.1 to about 1 percent; chromium from about 3 to about 6 percent; nickel up to about 4 percent; vanadium from about 1 to about 3 percent; molybdenum from about 4 to about 7 percent; tungsten from about 4 to about 7 percent; cobalt from about 4 to about 7 percent; boron up to about 0.1 percent; nitrogen from about 0.001 to about 0.15 percent, aluminum from about 0.001 to about 0.6 percent, copper from about 0.1 to about 1 percent, sulfur up to about 0.3 percent, phosphorus up to about 0.3 percent, up to about 5 percent total of tantalum, titanium, hafnium and zirconium; iron from about 65 to about 80 percent; and incidental impurities. The alloy is suitable for use in elevated temperature applications such as in valve seat inserts for combustion engines. | 2022-08-04 |
20220243297 | COLD ROLLED STEEL SHEET - Provided is a steel sheet having: ferrite and pearlite composing 80% or more, in area fraction, of the microstructure; yield strength of 60 ksi or more; elongation of at least 23%; an n-value of at least 0.14; incidental impurities; and, in weight percent:
| 2022-08-04 |
20220243298 | NON-ORIENTED ELECTRICAL STEEL SHEET AND METHOD FOR MANUFACTURING SAME - Provided is a non-oriented electrical steel sheet having excellent adhesion with an insulating coating even if the thickness of the insulating coating is reduced. The non-oriented electrical steel sheet of the present disclosure has an insulating coating on at least one surface of the steel sheet, where the insulating coating has a P-concentrated layer on both a surface side and an interface side with a steel substrate, and a P concentration of the P-concentrated layer is higher than a P concentration in the steel substrate. | 2022-08-04 |
20220243299 | DEVICE AND METHOD FOR PEENING BY COUPLING LASER SHOCK WAVE AND ULTRASONIC SHOCK WAVE IN REAL TIME - The present invention provides a device for peening by coupling a laser shock wave and an ultrasonic shock wave in real time. The device includes a synchronization device, a laser device, two ultrasonic shock devices, a working platform and a control system. An upper casing is supported above a base through second hydraulic cylinders. Two supporting beams are provided under the upper casing through the second hydraulic cylinders. Limiting slide rails are provided under the upper casing through first hydraulic cylinders. The two ultrasonic shock devices are connected through the synchronization device, which is configured to synchronize movement and rotation of the two ultrasonic shock devices. The laser device is configured to generate a laser beam to pass through the upper casing and irradiate a surface of a workpiece. The control system controls the laser device to lag behind the two ultrasonic shock devices to perform laser shock. | 2022-08-04 |
20220243300 | BAUXITE PROCESSING METHOD - A bauxite processing method including: preliminarily grinding bauxites; mixing the bauxites as ground with magnetic field treated water into a pulp; exposing the pulp in a reaction chamber to a rotating magnetic field created by rotating ferromagnetic elements, carried out in a vortex layer generated by ferromagnetic elements rotating at a speed of at least 2800 rpm, to achieve a magnetoelastic effect and provide forces and energies which enable metal reduction; and separating a resulting metal oxide mixture. | 2022-08-04 |
20220243301 | SYSTEM AND PROCESS FOR THE RECOVERY OF TITANIUM, TITANIUM ALLOY, ZIRCONIUM AND ZIRCONIUM ALLOY SCRAP - A system for the recovery of titanium, titanium alloys, zirconium and zirconium alloys is disclosed. The system is fed with a mixture of chips including titanium chips, titanium alloy chips, zirconium chips and zirconium alloy chips, ferromagnetic chips and electrically conductive non-ferromagnetic chips. The system has at least one magnetic separator, a drying device and an Eddy current separator. | 2022-08-04 |
20220243302 | METHOD FOR PROCESSING COPPER AND NICKEL SULFIDE MATERIALS - A method of processing copper and nickel sulfide materials, including oxidizing torrefaction of a material to obtain cinder, leaching the cinder with a cycling solution, separating a leaching residue, and electro-extraction of copper from a leaching solution. The cinder and particulates generated by the torrefaction are separately leached. The particulates are leached in a cycling copper raffinate together with a separated portion of solution from a cinder processing line, the separated portion consisting of a portion of solution provided to the leaching after electro-extraction of copper. Particulates leaching residue is separated. Copper is extracted by solvent extraction from a particulates leaching solution, followed by separate electro-extraction of copper from a circulating re-extract. Then, a portion of the raffinate is separated to be forwarded to a nickel production process. | 2022-08-04 |
20220243303 | MATERIALS AND METHODS FOR PRODUCING METAL NANOCOMPOSITES, AND METAL NANOCOMPOSITES OBTAINED THEREFROM - Some variations provide a metal matrix nanocomposite composition comprising metal-containing microparticles and nanoparticles, wherein the nanoparticles are chemically and/or physically disposed on surfaces of the microparticles, and wherein the nanoparticles are consolidated in a three-dimensional architecture throughout the composition. The composition may serve as an ingot for producing a metal matrix nanocomposite. Other variations provide a functionally graded metal matrix nanocomposite comprising a metal-matrix phase and a reinforcement phase containing nanoparticles, wherein the nanocomposite contains a gradient in concentration of the nanoparticles. This nanocomposite may be or be converted into a master alloy. Other variations provide methods of making a metal matrix nanocomposite, methods of making a functionally graded metal matrix nanocomposite, and methods of making a master alloy metal matrix nanocomposite. The metal matrix nanocomposite may have a cast microstructure. The methods disclosed enable various loadings of nanoparticles in metal matrix nanocomposites with a wide variety of compositions. | 2022-08-04 |
20220243304 | LOW-COST, HIGH-STRENGTH, CAST CREEP-RESISTANT ALUMINA-FORMING ALLOYS FOR HEAT-EXCHANGERS, SUPERCRITICAL CO2 SYSTEMS AND INDUSTRIAL APPLICATIONS - An austenitic Ni-base alloy includes, in weight percent: 2.5 to 4.75 Al; 13 to 21 Cr; 20 to 40 Fe; 2 to 5 total of at least one element selected from the group consisting of Nb and Ta; 0.25 to 4.5 Ti; 0.09 to 1.5 Si; 0 to 0.5 V; 0 to 2 Mn; 0 to 3 Cu; 0 to 2 of Mo and W; 0 to 1 of Zr and Hf; 0 to 0.15 Y; 0.01 to 0.45 C; 0.005 to 0.1 B; 0 to 0.05 P; less than 0.06 N; and balance Ni (38 to 46 Ni). The weight percent Ni is greater than the weight percent Fe. An external continuous scale comprises alumina. A stable phase FCC austenitic matrix microstructure is essentially delta-ferrite-free, and contains one or more carbides and coherent precipitates of γ′ and exhibits creep rupture life of at least 100 h at 900° C. and 50 MPa. | 2022-08-04 |
20220243305 | SUPERALLOY POWDER, PART AND METHOD FOR MANUFACTURING THE PART FROM THE POWDER - A nickel-based superalloy powder comprising, by mass percent, 14.00 to 15.25% chromium, 14.25 to 15.75% cobalt, 3.9 to 4.5% molybdenum, 4.0 to 4.6% aluminum, 3.0 to 3.7% titanium, 0 to 200 ppm carbon, the remainder consisting of nickel and unavoidable impurities. Component made from the powder and manufacturing process of the component. | 2022-08-04 |
20220243306 | POWDER CONSISTING OF A NICKEL-COBALT ALLOY, AND METHOD FOR PRODUCING THE POWDER - Nickel-cobalt alloy for powder, wherein the contents (in wt %) are defined as follows:
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20220243307 | ALUMINUM-BASED ALLOY HAVING IMPROVED MECHANICAL STRENGTH IN AGEING AT HIGH TEMPERATURES AND ADAPTED TO RAPID SOLIDIFICATION - The invention relates to an aluminum alloy includes, in mass percentages 3 to 6% titanium, 1.5 to 3% manganese, 1 to 2% iron, 1 to 2% chromium, 0.5 to 1.5% vanadium, 0.5 to 1.5% nickel, 0.2 to 1% zirconium, 0 to 0.5% cerium, 0 to 0.5% lanthanum, the remainder being aluminum and unavoidable impurities. | 2022-08-04 |
20220243308 | SPHEROIDAL GRAPHITE CAST IRON, CAST ARTICLE AND AUTOMOBILE STRUCTURE PART MADE THEREOF, AND METHOD FOR PRODUCING SPHEROIDAL GRAPHITE CAST IRON ARTICLE - A spheroidal graphite cast iron meeting N | 2022-08-04 |
20220243309 | FERRITIC STAINLESS STEEL SHEET FOR COLLECTORS OF SULFIDE-BASED SOLID-STATE BATTERIES - A ferritic stainless steel sheet for collectors of sulfide-based solid-state batteries has excellent sulfurization resistance. This ferritic stainless steel sheet has a component composition which contains, in mass %, from 0.001% to 0.050% of C, from 0.01% to 2.00% of Si, from 0.01% to 1.00% of Mn, 0.050% or less of P, 0.010% or less of S, from 18.00% to 32.00% of Cr, from 0.01% to 4.00% of Ni, from 0.001% to 0.150% of Al and 0.050% or less of N, with the balance being made up of Fe and unavoidable impurities. | 2022-08-04 |
20220243310 | ULTRA-THIN ULTRA-HIGH STRENGTH STEEL WIRE, WIRE ROD AND METHOD OF PRODUCING WIRE ROD - The present invention reveals an ultra-thin ultra-high strength steel wire, a wire rod for an ultra-thin ultra-high strength steel wire and its producing method. The chemical components of the wire rod comprise in percentage by mass: C 0.90˜0.96%, Si 0.12˜0.30%, Mn 0.30˜0.65%, Cr 0.10˜0.30%, Al≤0.004%, Ti≤0.001%, Cu≤0.01%, Ni≤0.01%, S≤0.01%, P≤0.01%, O≤0.0006%, N≤0.0006%, and the balance is Fe and unavoidable impurity elements. The wire rod for the ultra-thin ultra-high strength steel wire may be used as a base material for producing the ultra-thin ultra-high strength steel wire having a diameter in a range of 50˜60 μm and a tensile strength larger than or equal to 4500 MPa. | 2022-08-04 |
20220243311 | METHOD FOR MANUFACTURING OR MODIFYING AN ENDODONTIC INSTRUMENT OF NITI ALLOY - The invention relates to a method for manufacturing or modifying an endodontic instrument made from an NiTi alloy, comprising a heat-treatment. The invention further relates to an endodontic instrument, preferably obtained by the method, having superior properties with regard to cyclic fatigue resilience. | 2022-08-04 |
20220243312 | METHOD FOR MANUFACTURING A PART MADE OF A MONOCRYSTALLINE SUPERALLOY - The invention concerns a method for manufacturing an aircraft part, the part comprising a monocrystalline nickel-based superalloy substrate, the method consecutively implementing the steps of moulding the part at a moulding temperature greater than the melting temperature of the superalloy, and cooling the part, such that the monocrystalline superalloy has a γ phase and a γ phase, solution heat treatment of the part at a first temperature between the solves temperature of the γ′ phase and the melting temperature of the superalloy, homogenising the crystalline structure or the part, cooling the part to ambient temperature, first tempering and second tempering. | 2022-08-04 |
20220243313 | Coated Metal Substrates That Are Susceptible to Wear, and Method for the Manufacture Thereof - The use of tungsten, molybdenum, tungsten or molybdenum alloys for coating metal substrates using a single-wire arc spraying method results in coatings that are characterized in particular by an increased Vickers hardness (VH). | 2022-08-04 |
20220243314 | Tool Coating Processing Method - A tool coating processing method, comprising a molten pool forming step: converging a bonding phase ( | 2022-08-04 |
20220243315 | GRAIN ORIENTED ELECTRICAL STEEL SHEET, FORMING METHOD FOR INSULATION COATING OF GRAIN ORIENTED ELECTRICAL STEEL SHEET, AND PRODUCING METHOD FOR GRAIN ORIENTED ELECTRICAL STEEL SHEET - A grain oriented electrical steel sheet includes a base steel sheet, an oxide layer, and a tension-insulation coating. When a glow discharge spectroscopy is conducted in a region from a surface of the tension-insulation coating to an inside of the base steel sheet, a sputtering time Fe | 2022-08-04 |
20220243316 | HOLDING ARRANGEMENT FOR HOLDING A SUBSTRATE, CARRIER FOR SUPPORTING A SUBSTRATE, VACUUM PROCESSING SYSTEM, METHOD FOR HOLDING A SUBSTRATE, AND METHOD FOR RELEASING A SUBSTRATE - The present disclosure provides a holding arrangement. The holding arrangement for holding a substrate includes: a body portion having a first side; a dry adhesive material provided on the first side of the body portion; a seal surrounding the dry adhesive material and configured to provide a vacuum region on the first side, wherein the dry adhesive material is provided in the vacuum region; and a conduit to evacuate the vacuum region. | 2022-08-04 |
20220243317 | METHOD FOR MAKING A SOLAR CELL HAVING A TRANSPARENT ELECTRODE - A transparent electrode with a transparent substrate and a composite layer disposed thereon, wherein the composite layer includes a graphene layer and a plurality of nanoparticles, wherein the nanoparticles are embedded in the graphene layer and extend through a thickness of the graphene layer, and wherein the plurality of nanoparticles are in direct contact with the transparent substrate and a gap is present between the graphene layer and the transparent substrate. | 2022-08-04 |
20220243318 | COATED FORMING TOOLS WITH ENHANCED PERFORMANCE AND INCREASED SERVICE LIFE - Coated forming tool for processing of plastics materials or aluminum or aluminum alloy materials, comprising a substrate having a substrate surface, wherein the substrate surface is coated with a coating formed of one or more layers, wherein the coating comprises a Si—C—N-based layer having element composition in atomic percentage corresponding to Si | 2022-08-04 |
20220243319 | INDIUM COMPOUND AND METHOD FOR FORMING INDIUM-CONTAINING FILM USING SAID INDIUM COMPOUNDS - A process for forming an indium-containing film on at least part of the surface of a substrate, the process comprising (a) placing a substrate into a chamber; (b) introducing a vapor that includes an indium-containing compound into the chamber; (c) purging the chamber with a first purge gas; (d) introducing an oxygen-containing gas into the chamber; and (e) purging the chamber with a second purge gas; and (f) repeating steps (b)-(e) at a temperature of ≥225° C. and ≤400° C. until a desired thickness of the indium-containing film is obtained. | 2022-08-04 |
20220243320 | PRECURSOR SOURCE ARRANGEMENT AND ATOMIC LAYER DEPOSITION APPARATUS - A precursor source arrangement for an atomic layer deposition apparatus for receiving a liquid precursor container for liquid precursor. The precursor source arrangement includes a precursor container support arrangement arranged to hold the liquid precursor container in inclined position relative to vertical direction. | 2022-08-04 |
20220243321 | POWDER TRANSFER APPARATUS, GAS SUPPLY APPARATUS, AND POWDER REMOVAL METHOD - A powder transfer apparatus includes: a powder transfer pipe connecting a powder raw material supply source to a vaporizer and configured to supply a powder to the vaporizer from the powder raw material supply source; a first purge gas supply pipe connecting a buffer tank to the powder transfer pipe at a first branch point and configured to supply a purge gas from the buffer tank to the powder transfer pipe; a first valve that is closer to the powder raw material supply source than the first branch point is; a second valve that is closer to the vaporizer than the first branch point is, an opening degree of the second valve being adjustable; a first purge gas valve provided on the first purge gas supply pipe; and a controller configured to control opening and closing of the first valve, the second valve, and the first purge gas valve. | 2022-08-04 |
20220243322 | SUBSTRATE PROCESSING APPARATUS - Provided is a reactor capable of improving the symmetry of the profile of a thin film deposited on a substrate with an asymmetric exhaust structure, wherein a distance between a gas flow control ring (FCR) and an exhaust unit on one side where an exhaust port is located is greater than a distance between the FCR and the exhaust unit on the opposite side of the exhaust port. | 2022-08-04 |
20220243323 | USE OF ROTATION TO CORRECT FOR AZIMUTHAL NON-UNIFORMITIES IN SEMICONDUCTOR SUBSTRATE PROCESSING - A substrate processing system includes a substrate support and a controller. The substrate support includes a lift pad, a plurality of zones, and a plurality of resistive heaters arranged throughout the plurality of zones. The plurality of resistive heaters includes separately-controllable resistive heaters arranged in respective ones of the plurality of zones. The controller is configured to determine a rotational position of a substrate arranged on the lift pad, selectively rotate the lift pad to adjust the substrate to the rotational position, and control the plurality of resistive heaters to selectively adjust temperatures within the plurality of zones based on the rotational position. | 2022-08-04 |
20220243324 | FIXTURES AND METHODS FOR POSITIONING PROCESS KIT COMPONENTS WITHIN REACTION CHAMBERS - A fixture, for example, comprised in a semiconductor processing system, includes a standoff arranged for fixation relative to a reaction chamber of a semiconductor processing system. A slide member is slidably supported by the standoff and is translatable along a carrying axis extending into the reaction chamber. A male threaded member depends from the slide member and is rotatable about a seating axis that is angled relative to the carrying axis. A paddle member depends from the male threaded member, defines along the carrying axis, is fixed relative to slide member along the carrying axis to carry a component of a process kit into the reaction chamber using translation of the slide member, and is free relative to the slide member along the seating axis to seat the process kit component within the reaction chamber using rotation of the male threaded member. | 2022-08-04 |
20220243325 | Rotating Disk Reactor with Split Substrate Carrier - A self-centering split substrate carrier that supports a semiconductor substrate in a CVD system includes a first section configured to be centrally located in the split substrate carrier having a top surface with a recessed area for receiving a substrate for CVD processing and comprising a plurality of apertures positioned in an outer surface. A second section formed in a ring-shape having an inner surface configured to receive the first section and an outer surface configured to interface with an edge drive rotation mechanism that rotates the substrate carrier. The inner surface comprising a plurality of boss structures, wherein a respective one of the plurality of boss structures on the inner surface of the second section is configured to fit into a respective one of the plurality of apertures positioned in the outer surface of the first section, so as to improve alignment of the first and the second section of the self-centering split substrate carrier. | 2022-08-04 |
20220243326 | APPARATUS AND METHOD FOR THIN FILM DEPOSITION - A thin film deposition system including a modular reactor head, a substrate stage and a modular reactor head positioning system. The modular reactor head positioning positions the modular reactor head with respect to the substrate to deliver precursor gases to a substrate located on the substrate stage. The modular reactor head includes a set of modular components that perform different functionalities and may be placed in different configurations. | 2022-08-04 |
20220243327 | PROCESSING APPARATUS AND PROCESSING METHOD - A processing apparatus includes: a processing container having a substantially cylindrical shape; an injector provided to extend in a longitudinal direction along an inner side of an inner wall of the processing container and including a plurality of introduction ports into which a processing gas is introduced and a plurality of gas holes from which the processing gas introduced from the plurality of introduction ports is ejected into the processing container; and a controller configured to change a flow rate ratio of the processing gas to be introduced into the injector from the plurality of introduction ports. | 2022-08-04 |
20220243328 | PRECURSOR SOURCE ARRANGEMENT AND ATOMIC LAYER DEPOSITION APPARATUS - A precursor source arrangement for an atomic layer deposition reactor and to an atomic layer deposition apparatus wherein the precursor source arrangement includes a valve chamber having one or more supply valves, and a precursor source chamber having a precursor container space inside the precursor source chamber. The precursor source chamber includes a precursor source heat transfer element arranged to heat the precursor container inside the precursor container space. The valve chamber includes a valve chamber heat transfer element arranged to heat the one or more valves inside the valve chamber, and the valve chamber heat transfer element is arranged in heat transfer contact with the precursor source heat transfer element. | 2022-08-04 |
20220243329 | PROCESSING APPARATUS AND PROCESSING METHOD - A processing apparatus includes: a processing container; a first injector extending in a longitudinal direction along an inner wall of the processing container, wherein the first injector includes a first introduction port formed at a lower end and first gas holes formed in the extending portion; and a second injector extending upward along the inner wall of the processing container, folded back at an upper portion, and then extending downward, wherein the second injector includes a second introduction port formed at a lower end of an upward extending portion and second gas holes formed in a downward extending portion. The first injector includes a first throttle portion having a cross-sectional area decreasing as a distance from the first introduction port increases. The second injector includes a second throttle portion formed in the downward extending portion and having a cross-sectional area decreasing as a distance from the second introduction port increases. | 2022-08-04 |
20220243330 | Method of deposition and method of fabricating electronic device using the same - A deposition method may include: providing a structure to be deposited that includes a silicon oxide area and a silicon nitride area having different surface characteristics from each other; and performing an atomic layer deposition (ALD) process in a reactor provided with the structure to selectively form a silicon oxide layer on the silicon oxide portion between the silicon oxide portion and the silicon nitride portion. The ALD process may include: supplying a silicon precursor into the reactor to selectively adsorb the silicon precursor to a surface of the silicon oxide portion; purging the reactor; supplying an inhibitor material into the reactor to selectively adsorb the inhibitor material to a surface of the silicon nitride portion; purging the reactor; supplying an oxygen-containing source into the reactor; and purging the reactor. | 2022-08-04 |
20220243331 | SYMMETRIC PUMP DOWN MINI-VOLUME WITH LAMINAR FLOW CAVITY GAS INJECTION FOR HIGH AND LOW PRESSURE - Aspects of the present disclosure provide systems and apparatuses for a substrate processing assembly with a laminar flow cavity gas injection for high and low pressure. A dual gas reservoir assembly is provided in a substrate processing chamber, positioned within a lower shield assembly. A first gas reservoir is in fluid communication with a processing volume of the substrate processing assembly via a plurality of gas inlet, positioned circumferentially about the processing volume. A second gas reservoir is positioned circumferentially about the first gas reservoir, coupled therewith via one or more reservoir ports. The second gas reservoir is in fluid communication with a first gas source. A recursive path gas assembly is positioned in an upper shield body adjacent to an electrode to provide one or more gases to a dark space gap. | 2022-08-04 |
20220243332 | TEMPERATURE CONTROL OF A MULTI-ZONE PEDESTAL - A system to process a semiconductor substrate includes a substrate support assembly configured to support the semiconductor substrate. The substrate support assembly includes M resistive heaters respectively arranged in M zones in a layer of the substrate support assembly, where M is an integer greater than 1. The layer is adjacent to the semiconductor substrate. The substrate support assembly includes N temperature sensors arranged at N locations in the layer, where N is an integer greater than 1 and less than or equal to M. The system further includes a controller configured to control one or more of the M resistive heaters based on a temperature sensed by one of the N temperature sensors and average temperatures of one or more of the M zones. | 2022-08-04 |
20220243333 | Microwave System for Microwave-Assisted Surface Chemistry Annealing of ALD Processes Utilizing Microwave Radiation Energy - A microwave system for use within a microwave-assisted thermal atomic layer deposition system is disclosed which include at least one microwave generator configured to output at least one microwave signal, at least one waveguide assembly in communication with the at least one microwave generator and configured to receive the microwave signal, one or more isolators positioned within the waveguide assembly and configured to reduce or eliminate backscatter of the microwave signal from the waveguide assembly to the at least one microwave generator, at least one tuning device in positioned within the waveguide assembly and configured receive the microwave signal from the isolator and tune the microwave signal, and at least one microwave delivery device in communication with the waveguide assembly and configured to direct at least a portion of the microwave signal into at least one processing chamber of the microwave-assisted thermal atomic layer deposition system. | 2022-08-04 |