30th week of 2012 patent applcation highlights part 46 |
Patent application number | Title | Published |
20120190491 | WHEEL HUB MOTOR - An electric vehicle driving device | 2012-07-26 |
20120190492 | VEHICLE DRIVE - A twin engine having a powershift transmission in front longitudinal arrangement. | 2012-07-26 |
20120190493 | COUPLING DEVICE - A coupling device includes a clutch mechanism portion that is provided between a propeller shaft and a drive pinion shaft, and that engages by viscous resistance of hydraulic fluid. This coupling device is able to transmit driving force from a driving source to the drive pinion shaft by the engagement of this clutch mechanism portion. Also, an oil pump is provided that supplies hydraulic fluid not used for engaging the clutch mechanism portion to the clutch mechanism portion when the drive pinion shaft rotates. | 2012-07-26 |
20120190494 | Differential - A differential, having at least one drive gear, at least two axle gears, at least one compensating gear, and at least one connector element, in which the connector element is subjected to at least one first torque from the drive gear and transmits at least one second torque to at least one of the at least two axle gears. The drive gear is constructed in such a manner that the drive gear at least partially encloses at least one interior space, and the connector element is arranged at least partially inside the interior space enclosed at least partially by the drive gear. | 2012-07-26 |
20120190495 | DYNAMIC DAMPER DEVICE - A dynamic damper device includes a planetary gear mechanism including plural differentially rotatable rotating elements, an elastic member that couples a rotating shaft rotated by being transmitted with a power with a first rotating element of the planetary gear mechanism, speed control devices that are coupled with second rotating elements different from the first rotating element and control rotation speeds of the second rotating elements, and a torque control device that is coupled with the first rotating element and controls torque acting on the first rotating element. Accordingly, the dynamic damper device achieves an effect that vibration can be appropriately reduced. | 2012-07-26 |
20120190496 | MULTI-SPEED TRANSMISSION WITH SELECTABLE ONE-WAY BRAKING CLUTCH - A multi-speed transmission for a vehicle is provided with a selectable one-way braking clutch (SOWBC). The transmission has multiple planetary gear sets. Multiple torque-transmitting mechanisms are engagable in different combinations to establish at least one reverse speed ratio and multiple forward speed ratios between an input member and an output member. A selectable one-way braking clutch is configured to brake in one rotational direction and is selectively reversible to brake in an opposite rotational direction, and freewheels in some speed ratios. | 2012-07-26 |
20120190497 | Power Generation Coupler - The inventive technology described herein generally relates to the field of power generation. More specifically, methods and apparatus for a power generation coupler utilizing perhaps multiple generators coupled through a power generation coupler to at least one rotational movement element such that said coupled connection is dynamically movable across the surface the rotational movement element so as to maintain an electrical output at a constant generator rotation(s) per minute (RPM) according to the varying rotational velocity along the radius of a rotational movement element. In some embodiments such coupled generators may be sequentially loaded and disengaged to such rotational movement element to maintain an electrical output at a constant generator RPM. Certain embodiments may include a static power generation coupler as well as an electrically dynamic power generation coupler such that the current applied to the stator of a generator may dynamically alter that generators resistance. | 2012-07-26 |
20120190498 | Control Strategy for Multi-Mode Vehicle Propulsion System - A method for controlling a propulsion system for a vehicle including a transmission coupling an output shaft of the internal combustion engine to a drive wheel of the vehicle, wherein said transmission includes a lash region, the method comprising of adjusting an operating parameter of the engine so that at least one cylinder of the engine is transitioned between a first combustion mode and a second combustion mode, and varying a timing of said transition responsive to whether the transmission is operating within the lash region of the transmission. | 2012-07-26 |
20120190499 | CONTROL APPARATUS FOR VEHICULAR DRIVE SYSTEM - Providing a control apparatus for a vehicular drive system, which permits economical and easy reduction of generation of an abnormal sound upon starting of an engine in a running state of a vehicle. The control apparatus includes on-engine-starting differential limiting means for commanding a differential limiting clutch to limit differential rotary motion between front and rear drive wheels, in advance of automatic starting of an engine under the control of automatic engine starting control means. Accordingly, the limitation of the differential rotary motion between the front and the rear drive wheels by the differential limiting clutch ensures the starting of the engine without backlash which exists in the power transmitting path between the engine and the front and rear drive wheels, thereby permitting economical and easy reduction of generation of the abnormal sound upon starting of the engine in a running state of the vehicle. | 2012-07-26 |
20120190500 | VEHICLE CONTROLLER SYSTEM - A vehicle control system for a vehicle includes an engine control device configured to automatically stop an engine of the vehicle during running of the vehicle; and a brake control device configured to execute an assisting control for increasing an output of a brake for restraining rotation of a wheel of the vehicle when a starting condition for starting the assisting control is satisfied, such that an amount of the output increased by execution of the assisting control becomes larger than an amount corresponding to an operational state of a brake operating member of the vehicle. The brake control device includes an automatic-stop assisting control portion configured, during an automatic stop state in which the engine is automatically stopped by the engine control device, to execute the assisting control in a manner different from a manner in which the assisting control is executed during an activation state of the engine. | 2012-07-26 |
20120190501 | SPEED AND/OR AGILITY TRAINING DEVICES AND SYSTEMS AND METHODS FOR USE THEREOF - Disclosed herein are training devices useful for improving the agility and/or speed of a trainee, systems comprising same, and methods of improving a trainee's agility and/or speed. In one embodiment a training device comprises a first sensor operatively associated with a control mechanism, wherein the control mechanism is optionally configured to enable the device to move (a) randomly, (b) in a predetermined movement pattern, or (c) in relation to a second sensor. | 2012-07-26 |
20120190502 | ADAPTIVE EXERCISE PROFILE APPARATUS AND METHOD OF USE THEREOF - The invention comprises a method and/or an apparatus using computer configured exercise equipment and an electric motor. A computer-controlled robotic resistance system is used for training, diagnosis and/or therapy. The resistance system comprises: a subject interface, software control, a controller, an electric servo assist/resist motor, an actuator, and/or a subject sensor. The system overcomes the limitations of the existing robotic rehabilitation, weight training, and cardiovascular training systems by providing a training and/or rehabilitation system that adapts a resistance or force applied to a user interactive element in response to the user's interaction with the training system, a physiological strength curve, and/or sensor feedback. For example, the system optionally provides for an automatic reconfiguration and/or adaptive load adjustment based upon real time measurement of a user's interaction with the system or sensor based observation by the exercise system as it is operated by the subject. | 2012-07-26 |
20120190503 | Method and apparatus for electronically controlled resistance in exercise equipment - A system for controlling the tension in an exercise apparatus includes a plurality of connectors that are collectively attached to a holder, the holder being movable relative to a fixed support, each connector further comprising a catch for independent attachment to a tension member from an exercise apparatus. Different combinations of tension members can be attached to the connectors with an electronic control system to create a desired tension arrangement, while the holder including all of the connectors can be moved to further fine tune the tension arrangement of the tension members. | 2012-07-26 |
20120190504 | VIRTUAL REALITY SYSTEM FOR EXERCISE EQUIPMENT AND METHOD THEREOF - A virtual reality system and method for exercise equipment are provided. The virtual reality system includes a configuration module, a processing module, a movement detection module, an electronic compass, and a display apparatus. The display apparatus displays the geographic information of the start point of the route, the current position of a user, and the visual angle corresponding to the orientation of the head of the user. | 2012-07-26 |
20120190505 | METHOD AND SYSTEM FOR MONITORING AND FEED-BACKING ON EXECUTION OF PHYSICAL EXERCISE ROUTINES - A system for monitoring performance of a physical exercise routine comprises a Pilates exercise device enabling a user to perform the physical exercise routine, a plurality of motion and position sensors for generating sensory information that includes at least position and movements of a user performing the physical exercise routine; a database containing routine information representing at least an optimal execution of the physical exercise routine; a training module configured to separate from sensory information at least appearance of the Pilates exercise device, compare the separated sensory information to the routine information to detect at least dissimilarities between the sensory information and the routine information, wherein the dissimilarities indicate an incorrect execution of the physical exercise routine, the training module is further configured to feedback the user with instructions related to correcting the execution of the physical exercise routine by the user; and a display for displaying the feedback. | 2012-07-26 |
20120190506 | Jaw Exerciser - A jaw exerciser is provided. The jaw exerciser includes an elongated first portion having a first cross-sectional area, wherein the elongated first portion is configured to be inserted into the mouth, and includes an outer surface adapted to be engaged and clenched by the teeth. The jaw exerciser also includes an elongated second portion having a second cross-sectional area and an outer surface, wherein the elongated second portion is configured to remain outside the mouth when the first portion is inserted into the mouth. Furthermore, the jaw exerciser includes an intermediate portion having a third cross-sectional area. The intermediate portion joins the elongated first and second portions, and is configured to be grasped and encircled by the lips to thereby retain saliva inside the mouth. | 2012-07-26 |
20120190507 | ADJUSTABLE EXERCISE MACHINE - Stationary exercise machines having adjustable incline systems are disclosed herein. In one embodiment, for example, an elliptical exercise machine includes a system for adjusting the inclination of foot support guide tracks. The incline adjustment system can include a lift member that operates between the guide tracks and the floor on which the exercise machine is placed. | 2012-07-26 |
20120190508 | ELLIPTICAL EXERCISE MACHINE WITH DECLINING ADJUSTABLE RAMP - An elliptical exercise machine includes a base support structure adapted to be positioned on a support surface. The machine includes first and second reciprocating foot supports, each foot support being movably linked to the base support structure. Additionally, a ramp assembly is situated on the base support structure, the ramp assembly having first and second guide rails for guiding the respective second ends of the first and second foot supports such that the foot supports move in an elliptical path when the elliptical exercise machine is operating. Moreover, a first support member is linked to the base support structure, wherein the first support member is pivotably linked to the ramp assembly at a point above the base support structure. Furthermore, a lift mechanism is linked on a first end to the base support structure and pivotably linked on a second end to the ramp assembly above the base support structure. | 2012-07-26 |
20120190509 | UPPER BODY EXERCISE AND FLYWHEEL ENHANCED DUAL DECK TREADMILLS - An exercise device includes a first treadle assembly supporting a first moving surface and a second treadle assembly supporting a second moving surface. The exercise device further includes an upper body exercise assembly operably associated with the exercise device. The first treadle assembly is pivotally coupled with the frame structure, and the second treadle assembly is pivotally coupled with the frame structure. In another form, an exercise device includes a frame structure, a first treadle assembly having a first endless belt in rotatable engagement with a first roller, a second treadle assembly having a second endless belt in rotatable engagement with a second roller, and a flywheel operably coupled with the first endless belt and the second endless belt. | 2012-07-26 |
20120190510 | Suspension Exercising Device Having Adjustable Length - A suspension exercising device includes an elongate strip, at least two fixing members adjustably mounted on the elongate strip, and a holding tube mounted on the elongate strip. The elongate strip is extended through the fixing members to and fro to form at least two loops. Thus, the elongate strip is extended through the fixing members to and fro so that the elongate strip is adjustable on the fixing members and has an adjustable length so as to facilitate the user operating the suspension exercising device so that the suspension exercising device is available for users of different height. | 2012-07-26 |
20120190511 | LEG EXERCISE APPARATUS AND METHOD OF CONDUCTING PHYSICAL THERAPY USING SAME - A leg exercise apparatus having a supporting frame, a leg disposition assembly and a connecting panel. The supporting frame is pivotably connected to the leg disposition assembly, and an upper portion of the connecting panel is pivotably connected to the leg disposition assembly on its backside. A positioning bar passes through a lower portion of the connecting panel and is disposed in positioning grooves located on both arms of the supporting frame to secure the connecting panel. An end opening is located at an end of the supporting frame and connects to two tunnel grooves at both arms so the positioning bar can be pushed out through the tunnel grooves and end opening, which leads the leg disposition assembly to collapse into the supporting frame to form a compact and portable leg exercise apparatus. | 2012-07-26 |
20120190512 | Hand Held Exercising Device that is Assembled Solidly - An exercising device includes a main body having an elongate cord and a grip, and a weight unit adjustably mounted on the cord. The weight unit includes a connecting block mounted on the cord, and a weighting block mounted on the connecting block. The connecting block has a flexible tapered mounting post and has a mounting hole. The weighting block has a tapered pressing hole pressing the mounting post. Thus, the mounting hole of the connecting block encircles the cord completely so that when the mounting post is pressed toward the cord by the pressing hole of the weighting block, the connecting block compresses the cord tightly so as to lock the weight unit on the cord of the main body. | 2012-07-26 |
20120190513 | Active Activator A - The present invention provides a new innovated exercise machine comprising a universal exercise machine designed with extreme ergonomic designs with dimensions less than 34 inches square and no high than 6 inches when compacted and a total weight under 60 pounds. The device is cleverly designed for easy and quick break down for storage under the bed, closet or in any corner of any room. | 2012-07-26 |
20120190514 | EXERCISE SYSTEM USING EXERCISE RESISTANCE CABLES - An exercise chair for an exercise system. The exercise system is of a type that utilizes an exercise resistance cable apparatus of a type that includes an exercise resistance cable having a first end being connectable to an exercise chair, and; a handgrip connected to a second end of the exercise resistance cable. The exercise chair includes: a) a chair frame; b) a first force directing means securely attached to the chair frame at a first selected location at approximately shoulder height level at the left side of the chair frame; c) a second force directing means securely attached to the chair frame at a second selected location at approximately shoulder height level at the right side of the chair frame; d) a third force directing means securely attached to the chair frame at a third selected location at approximately ankle height level at the right side of the chair frame; e) a fourth force directing means securely attached to the chair frame at a fourth selected location at approximately ankle height level at the left side of the chair frame; and, f) means for connecting the first end of a resistance cable to a selected position on the chair frame. The first, second, third and fourth force directing means provide a redirection of force applied by a user at the shoulder and ankle height levels for a selectable exercise using resistance cables. | 2012-07-26 |
20120190515 | LIMB AND LIMB EXTREMITY EXERCISE DEVICE - This invention relates to an exercise device suitable for progressively strengthening the intrinsic muscle groups of a limb extremity and the associated limbs of a user, said device comprising a base unit; a gripping surface configured to be gripped by at least one of the digits of said limb extremity of said user; and a resistance means. This invention more specifically relates to such an exercise device wherein the gripping surface is configured to adapt to fit the shape of said at least one of the digits of said limb extremity of said user. | 2012-07-26 |
20120190516 | Slidable Exercise Apparatus - A slidable exercise apparatus includes a pair of platforms, each platform including a base having opposed upper and lower generally planar surfaces and a generally rigid construction. A pad has a lower surface attached to the base upper surface and has a generally cushioned construction. Each platform includes a plurality of skid plates situated on the base lower surface, each skid plate having a smooth outer surface configured to slide on a floor surface. | 2012-07-26 |
20120190517 | Arched abdominal (multipurpose) exercise device - The present invention is an awesome abdominal exercise bench device with a multipurpose function to replace traditional flat benches. This device will help work and tone all parts of the body, while the abdominal muscles are in a stretched and elongated state, during all the exercises, it can aid with. This bench is an arched shape bench. The body is made up of 2 metal (steel) tubing's bent in an arch shape, and is connected with a welded metal meshwork, which is also in an arched shape of a somewhat of a semicircular shape. The whole bench is curved in a semi-lunar form, including the leg and the support system. This can withstand great body masses. The bench has leather surface padding, sized and built over the bench, to provide comfort, and no slipping during exercise. | 2012-07-26 |
20120190518 | INJECTION MOLD APPARATUS AND METHOD UTILIZING SHAFT ROTATION FOR THE MANUFACTURE OF ROLL DEVICES - A method for manufacturing a roll. The method includes positioning a shaft for the roll within a mold, introducing flowable material into the mold from a first end thereof, rotating the shaft at least about 20 revolutions, and following introducing the flowable material into the mold and rotating the shaft, curing the material at an elevated temperature. The method substantially reduces or otherwise eliminates weld lines and flow lines in the manufactured roll. | 2012-07-26 |
20120190519 | CUP MADE OF A PAPER MATERIAL - A cup made of a paper material having a fillable interior, which cup is formed by a conical sleeve and a bottom. The bottom is attached to the sleeve at the lower end of the interior with a bottom skirt in an essentially liquid-tight way. The sleeve and/or the bottom in the area of the bottom skirt and/or the bottom skirt itself comprises, at least in one area along the periphery, an outwardly projecting widening. A lower edge of the widening forms a standing surface for the cup. The widening can serve to hold another cup of the same type, and can act together with a similar cup during stacking. The cup can include a heat insulating outer sleeve. | 2012-07-26 |
20120190520 | Beverage Pod Packaging Manufacturing Machine - A filter paper cup manufacturing machine produces filter paper cups packaging suitable for containing a brewing material. The filter paper cup packaging has similar depth and diameter. The machine exercises ordered steps of first cutting a receptacle portion and cover portion for each individual packaging and then forming a recess in the receptacle portion for receiving the brewing material. Performing the cutting step first facilitates forming the recess because surrounding filter paper which would resist forming the recess has been eliminated. | 2012-07-26 |
20120190521 | Beverage Pod Manufacturing Machine - A filter paper cup manufacturing machine produces filter paper cups containing a brewing material. The filter paper cups have similar depth and diameter. The machine exercises ordered steps of first cutting a receptacle portion and then forming a recess in the receptacle portion for receiving the brewing material. Performing the cutting step first facilitates forming the recess because surrounding filter paper which would resist forming the recess has been eliminated. | 2012-07-26 |
20120190522 | Microwave Cooking Tray with Pop-Up Legs - A microwave cooking tray includes pop-up legs. The microwave cooking tray is formed from a blank including a main panel, at least two leg portions, each leg portion having a first panel connected to the main panel by a first fold line, a second panel connected to the first panel by a second fold line, and a third panel connected to the second panel by a third fold line, and an aperture located on each of the first fold line between the main panel and each of the first panels. When assembled each of the third panels lies flat against an underside of the main panel, such that each of the third panels reinforces the main panel, and the first panel and second panel extend downward from the underside of the main panel to form triangular legs resting on an edge. | 2012-07-26 |
20120190523 | MACHINE FOR MAKING ABSORBENT ITEMS - A machine for making absorbent items comprises a conveyor ( | 2012-07-26 |
20120190524 | FOLDING APPARATUS AND METHOD - Apparatuses and methods of forming discrete stacks of a plurality of zig-zag folded panels are provided. The apparatus and methods include defining a sheet to form all of the panels of the discrete stack of panels. The sheet may be defined by cutting the sheet from the web prior to folding the web into the interconnected panels for each sheet. The sheet may be defined by forming a separation line prior to folding the web into the interconnected panels for each sheet and then separating the sheet from the web of material at the separation line after the web of material is folded into the interconnected panels. | 2012-07-26 |
20120190525 | SHEET PROCESSING APPARATUS, IMAGE FORMING SYSTEM AND SHEET PROCESSING METHOD - According to one embodiment, a sheet processing apparatus includes a roller unit having a reinforce roller which moves along a fold of a sheet perpendicular to the sheet conveying direction and thereby further reinforces the fold by the reinforce roller, and a control unit which counts the number of halts of the roller unit generated during the reinforcing operation of the sheet, and in case that the counted number of the halts of the roller unit is less than a prescribed number of times, makes the roller unit to be moved to a retract position and then makes the roller unit to be driven again to perform the reinforcing operation. | 2012-07-26 |
20120190526 | SHEET PROCESSING APPARATUS, IMAGE FORMING APPARATUS AND SHEET PROCESSING METHOD - A sheet processing apparatus includes a folding roller unit configured to form a fold in a sheet while the sheet passes through a nip of rollers, and a fold-enhancing roller unit having a first roller, a second roller, and a third roller, the first roller being provided facing a first surface of the sheet, orthogonal to a direction of transport of the sheet, the second and third rollers being provided facing a second surface of the sheet orthogonal to the direction of transport of the sheet and different from the first surface, the second and third rollers forming nips with the first roller, in which the fold-enhancing roller unit is moved along the fold with the sheet nipped in the nip between the first roller and the second roller and in the nip between the first roller and the third roller, to form a fold. | 2012-07-26 |
20120190527 | SWING ROTOR FOR CENTRIFUGAL SEPARATOR AND CENTRIFUGAL SEPARATOR - A swing rotor for a centrifugal separator, the swing rotor including: a hub; and a rotor body disposed around the hub, wherein a plurality of pairs of arms are disposed at the rotor body, wherein a holding pin configured to hold a bucket is disposed to the arm, wherein an engagement portion which is configured to be supported by the holding pin is formed to the bucket, and wherein a sliding surface of the holding pin with an engagement portion of the bucket is formed such that a width of a contact area, which is an area that the holding pin contacts with the engagement portion of the bucket, in an axial direction when the bucket does not swing differs from a width of the contact area in the axial direction when the bucket reaches a horizontal position by swinging during a centrifugal separation operation. | 2012-07-26 |
20120190528 | DEVICE AND METHOD FOR PARTICLE SEPARATION - A separation device with a gas inlet port that accepts an inlet gas. The inlet gas is composed of a mixture of at least two separable particle components with each component having a different mass. A rotating separation rotor accepts the inlet gas and uses a separator to substantially separate the gas according to mass into two fractions, a heavier and a lighter fraction. One of the fractions is passed to a second separator that further separates that fraction into another two fractions consisting of heavier and lighter fractions. The desired fractions are collected and exhausted from the separation device for use. | 2012-07-26 |
20120190529 | HIGH ALKALI GLASS COMPOSITION - A glass composition useful in preparing fiberglass comprises 12 to 25 weight % CaO; 12 to 16 weight % Al | 2012-07-26 |
20120190530 | Dense Silicon Nitride Body Having High Strength, High Weibull Modulus and high fracture toughness - Silicon nitride materials with high strength, fracture toughness values, and Weibull moduli simultaneously, due to unique large grain reinforcing microstructures and well engineered grain boundary compositions. The invention demonstrates that, surprisingly and contrary to prior art, a silicon nitride material can be made which simultaneously has high strength above about 850-900 MPa, a Weibull above about 15 and high fracture toughness (above about 8 and 9 MPa·m | 2012-07-26 |
20120190531 | ALPHA-BETA SIALON BALLISTIC ARMOR CERAMIC AND METHOD FOR MAKING THE SAME - A SiAlON armor ceramic made from a starting powder mixture including silicon nitride powder. The armor ceramic includes a ceramic body that has between about 64 weight percent and about 90 weight percent alpha SiAlON phase that contains an alpha SiAlON-bound rare earth element. The ceramic body also has between about 5 weight percent and about 35 weight percent of a beta SiAlON phase of the formula Si | 2012-07-26 |
20120190532 | PHOTOCATALYTIC NANOCOMPOSITE STRUCTURED WITH BORON - This invention is related to a functional inorganic-organic hybrid nanocomposite structured with boron. With the present invention, a nanosized material is obtained with enhanced UV and Visible region activity wherein metal-oxide nanoparticle combinations with boron compounds are used. | 2012-07-26 |
20120190533 | METHOD FOR TREATING FLUE GAS CATALYST - A method for treating a catalyst base that comprises a contact area of porous material. A fluid, such as a flue gas stream, can be conducted along the contact area. A catalytically relevant substance is introduced into pores of the catalyst base using a transport fluid and remains on pore wall areas after removal of the transport fluid. The introduction is carried out such that an amount of the catalytically relevant substance relative to the surface remains on the pore wall areas as a function of location within the pore and decreases within the pore after exceeding a specific pore depth. A blocking fluid can first be introduced into pore regions beyond the specific pore depth, thus blocking these regions when transport fluid containing the catalytically relevant substance is introduced. | 2012-07-26 |
20120190534 | ZEOLITE BETA AND PROCESS FOR PRODUCING THE SAME - A zeolite beta according to the present invention has a SiO | 2012-07-26 |
20120190535 | SLURRY PREPARATION METHOD, SLURRY PREPARATION DEVICE, HYDROCARBON SYNTHESIS REACTION APPARATUS, AND HYDROCARBON SYNTHESIS REACTION SYSTEM - Provided is a preparation method of a catalyst slurry used for synthesizing hydrocarbons by contact with a synthesis gas which includes carbon monoxide gas and hydrogen gas as main components. The method includes the step of preparing the catalyst slurry having solid catalyst particles suspended in a liquid medium, wherein adopting a petroleum solvent which is a liquid at normal temperature and normal pressure as the liquid medium. | 2012-07-26 |
20120190536 | SUPPORTED CATALYST - A supported catalyst is prepared by a process that includes establishing shell-removal conditions for a supported catalyst intermediate that includes capped nanoparticles of a catalyst material dispersed on a carbon support. The capped nanoparticles each include a platinum alloy core capped in an organic shell. The shell-removal conditions include an elevated temperature and an inert gas atmosphere that is substantially free of oxygen. The organic shell is removed from the platinum alloy core under the shell-removal conditions to limit thermal decomposition of the carbon support and thereby limit agglomeration of the catalyst material such that the supported catalyst includes an electrochemical surface area of at least 30 m | 2012-07-26 |
20120190537 | CATALYST SUPPORT FROM FLAME-SPRAY PYROLYSIS AND CATALYST FOR AUTOTHERMAL PROPANE DEHYDROGENATION - The invention relates to a method of production of catalyst support particles, containing zirconium dioxide and optionally silicon oxide, comprising the steps
| 2012-07-26 |
20120190538 | CATALYST FROM FLAME-SPRAY PYROLYSIS AND CATALYST FOR AUTOTHERMAL PROPANE DEHYDROGENATION - The invention relates to a method of production of catalyst particles, comprising platinum and tin and also at least one further element, selected from lanthanum and cesium, on zirconium dioxide as support, comprising the steps: preparation of one or more solutions containing precursor compounds of Pt, Sn and at least one further element of La or Cs and also ZrO | 2012-07-26 |
20120190539 | CATALYST FOR PRODUCTION OF SYNTHESIS GAS - The present invention relates to a novel composite metal oxide catalyst, a method of making the catalyst, and a process for producing synthesis gas using the catalyst. The catalyst may be a nickel and cobalt based dual-active component composite metal oxide catalyst. The catalyst may be used to produce synthesis gas by the carbon dioxide reforming reaction of methane. The catalyst on an anhydrous basis after calcinations has the empirical formula: | 2012-07-26 |
20120190540 | METHOD FOR FORMING THERMALLY STABLE NANOPARTICLES ON SUPPORTS - An inverse micelle-based method for forming nanoparticles on supports includes dissolving a polymeric material in a solvent to provide a micelle solution. A nanoparticle source is dissolved in the micelle solution. A plurality of micelles having a nanoparticle in their core and an outer polymeric coating layer are formed in the micelle solution. The micelles are applied to a support. The polymeric coating layer is then removed from the micelles to expose the nanoparticles. A supported catalyst includes a nanocrystalline powder, thin film, or single crystal support. Metal nanoparticles having a median size from 0.5 nm to 25 nm, a size distribution having a standard deviation ≦0.1 of their median size are on or embedded in the support. The plurality of metal nanoparticles are dispersed and in a periodic arrangement. The metal nanoparticles maintain their periodic arrangement and size distribution following heat treatments of at least 1,000° C. | 2012-07-26 |
20120190541 | SULFUR RESITANT CLADDED TITANIA-ALUMINA SUPPORTS - The present invention is directed to a method of forming titania clad high surface area alumina suitable as a support for forming noble metal catalysts. The resultant catalysts exhibit resistance to poisoning by sulfurous materials and, therefore, are useful in applications directed to internal combustion engine emission conversion and the like. The present invention provides a commercially feasible and cost effective method of forming a highly desired support for noble metal catalyst application. The process comprises forming a slurry of porous alumina particulate suitable as a catalyst support for the intended application, mixing said slurry with a solution of titanyl sulfate having a pH of about 1, increasing the pH of the mixed slurry/solution at a slow rate of from 0.05 to 0.5 pH unit per minute to a pH of ≦4 by the addition of a basic solution, allowing the resultant slurry to age for a period of from 10 to 120 minutes, separating the treated porous alumina particulates and washing same free of sulfate with a weak base, drying and calcining said particulates to produce titania clad alumina particulate product. The resultant material exhibits a normalized sulfur uptake of less than about 45 μg/m | 2012-07-26 |
20120190542 | FUNGICIDAL MIXTURES AND THEIR USE - The present invention relates to pesticidal mixtures, compositions and uses thereof comprising a component (A) and a component (B), wherein components (A) and (B) are: (A) a carboxylic acid amide fungicide; and (B) a benzamide fungicide; with the proviso that the mixture does not comprise: 1). fluopicolide and mandipropamid and clothianidin; or 2). fluopicolide and mandipropamid and imidacloprid; or 3). fluopicolide and mandipropamid and thiamethoxam. The invention also relates to mixtures, compositions and uses thereof wherein component (A) is metalaxyl-M and component (B) is a benzamide fungicide. | 2012-07-26 |
20120190543 | PESTICIDAL COMPOSITIONS - The present invention concerns novel heteroaryl-N-aryl carbamates and their use in pest control, as insecticides and acaricides This invention also includes preparation of the pesticide compositions containing the compounds, and methods of controlling insects using the compounds. | 2012-07-26 |
20120190544 | ACTIVE INGREDIENT COMBINATIONS WITH INSECTICIDAL PROPERTIES - Agrochemical compositions comprising at least one active compound from the class of the anthranilamides and at least one further active compound selected from the group consisting of insecticides, fungicides, and/or acaricides have excellent synergistic activity. | 2012-07-26 |
20120190545 | NOVEL HERBICIDES - Compounds of formula (I) wherein the substituents are as defined in claim | 2012-07-26 |
20120190546 | HERBICIDAL COMPOSITION AND METHOD OF USE THEREOF - The present invention relates to method of controlling the growth of weeds, in particular white clover, using a herbicidal composition comprising mesotrione and oxadiazon. It also relates to the use of this composition. | 2012-07-26 |
20120190547 | Herbicidal Composition in Granular Form - The present invention provides light weight, water dispersible, granular compositions containing a first herbicide and a second herbicide in which the first herbicide and the second herbicide have different physical characteristics. In particular, the present invention relates to granular herbicidal compositions comprising a low melting point herbicide, carfentrazone-ethyl, and a high melting point herbicide, sulfosulfuron, having excellent dispersibility in water and chemical and physical stability. | 2012-07-26 |
20120190548 | 3-ALKENYL-6-HALO-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES - 3-Alkenyl-6-halo-4-aminopicolinic acids and their derivatives are potent herbicides demonstrating a broad spectrum of weed control. | 2012-07-26 |
20120190549 | 6-AMINO-2-SUBSTITUTED-5-VINYLSILYLPYRIMIDINE-4-CARBOXYLIC ACIDS AND ESTERS AND 4-AMINO-6-SUBSTITUTED-3-VINYLSILYLPYRIDINE-2-CARBOXYLIC ACIDS AND ESTERS AS HERBICIDES - 6-Amino-2-substituted-5-vinylsilylpyrimidine-4-carboxylates and 4-amino-6-substituted-3-vinylsilylpyridine-picolinates and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control | 2012-07-26 |
20120190550 | PROCESS FOR PREPARING AMMONIC GLYPHOSATE GRANULES - A process for preparing water-soluble granules of amnionic glyphosate comprising: a) addition of glyphosate acid to a Broensted base which supplies ammonium ions in a molar ratio base/acid comprised between 0.8 and 1.1; b) homogenization of the mixture prepared in a); c) addition of one or more surfactants in amounts in the range 5%-50% by weight based on the glyphosate acid; d) mixing of the mass prepared in c) for a time lower than about 10 minutes until obtaining an extrudable mass; e) extrusion of the mass obtained in d); f) drying until obtaining a granule having a residual moisture lower than 1%. | 2012-07-26 |
20120190551 | ARYLALKYL ESTERS OF 4-AMINO-6-(SUBSTITUTED PHENYL)-PICOLINATES AND 6-AMINO-2-(SUBSTITUTED PHENYL)-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS - Arylalkyl esters of 4-aminopicolinic acids and 6-amino-4-pyrimidinecarboxylates are herbicides for control of weeds especially those species common to rice and wheat cropping systems and in pasture management programs. | 2012-07-26 |
20120190552 | PRECOOLING DEVICE, SUPERCONDUCTING MAGNET AND MAGNETIC RESONANCE IMAGING APPARATUS - A precooling device for a thermal radiation shield of a superconducting magnet has a mechanical heat conductive member in contact with the thermal radiation shield of a superconducting magnet, for cooling the thermal radiation shield down to a second temperature before the second stage of precooling of the superconducting magnet, this second temperature being below the temperature of the thermal radiation shield after a first stage of precooling of the superconducting magnet. A superconducting magnet and magnetic resonance imaging equipment embody such a precooling device. The precooling device reduces the external radiation heat onto a cryogen vessel, thereby reducing the consumption of cryogen. | 2012-07-26 |
20120190553 | SUPERCONDUCTING JOINTS - In a cold superconducting joint, a joint cup is provided. Lengths of superconducting filaments are placed in the joint cup. A superconducting material fills the joint cup in contact with the superconducting filaments and in thermal and mechanical contact with a pipe carrying a cryogen. The pipe extends into the joint cup and the superconducting material extends around the pipe within the joint cup. | 2012-07-26 |
20120190554 | ELECTRIC DRIVE SHAFT AND VEHICLE COMPRISING SUCH AN ELECTRIC DRIVE SHAFT - An electric drive shaft is disclosed including at least one speed-variable generator for generating a voltage with a variable amplitude and a variable frequency, and at least one speed-variable drive motor supplied with the voltage. The drive shaft enables repercussions on the voltage during sudden load changes, and therefore the complexity of the regulation for stabilising the voltage, to be reduced due to the generator including a supraconductor winding, especially a high-temperature supraconductor winding. | 2012-07-26 |
20120190555 | CONSTRUCTION OF SUPERCONDUCTING MULTI-CORE BILLET AND METHOD FOR MANUFACTURING SUPERCONDUCTING MULTI-CORE WIRES - A physical construction of a superconducting multi-core billet is provided together with a method for manufacturing a superconducting multi-core wire to offer reduction of manufacturing time (cost) and low frequency of occurrence of wire break during diameter-reduction drawing. The superconducting multi-core billet by the present invention has such a construction that a plurality of vertical holes are made in a billet | 2012-07-26 |
20120190556 | PROCESS FOR APPLYING POLYMER TO INDIVIDUAL CONDUCTORS AND HTS COMPOSITE PRODUCED FROM THE INDIVIDUAL CONDUCTORS - A process applies a polymer to at least one individual conductor of a high-temperature superconductor (HTS) composite in the manner of a Roebel conductor. The at least one individual conductor includes a substrate and a superconducting layer. Particles are applied to the individual conductor. Then, a thermal treatment is performed which results in partial or complete melting of the particles and, after cooling, in a polymer layer on the individual conductor. | 2012-07-26 |
20120190557 | RISK CALCULATION FOR EVALUATION OF FETAL ANEUPLOIDY - The present invention provides processes for determining accurate risk probabilities for chromosome dosage abnormalities. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples. | 2012-07-26 |
20120190558 | SCHIZOPHRENIA-RELATED ISOFORM OF KCNH2 AND DEVELOPMENT OF ANTIPSYCHOTIC DRUGS - The invention is related to a novel primate specific brain isoform of the potassium channel KCNH2 and genetic association with risk for schizophrenia and response to therapy. | 2012-07-26 |
20120190559 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING PAIRED END - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 2012-07-26 |
20120190560 | METHOD FOR AUTOMATED, LARGE-SCALE MEASUREMENT OF THE MOLECULAR FLUX RATES OF THE PROTEOME OR THE ORGANEOME USING MASS SPECTROMETRY - Disclosed here is a method for measuring the kinetics (i.e., the molecular flux rates—synthesis and breakdown or removal rates) of a plurality of proteins or organic metabolites inn living systems. The methods may be accomplished in a high-throughput, large-scale automated manner, by using existing mass spectrometric profiling techniques and art well known in the fields of static proteomics and static organeomics, without the need for additional biochemical preparative steps or analytic/instrumental devices. | 2012-07-26 |
20120190561 | MEANS AND METHODS FOR DIAGNOSING ENDOMETRIOSIS - The present invention relates to means and methods for diagnosing or predicting endometriosis in a female subject. Particularly, the present invention relates to methods for determining the susceptibility to, predisposition for, presence of and/or risk of developing or suffering from endometriosis in a female subject. The present invention also relates to a kit useful for determining the risk of developing or suffering from endometriosis in a subject, a binding molecule specifically binding to the DBP GC*2 or DBP GC*1 allele product, and a binding molecule binding to the gene encoding the DBP GC*2 or GC*1 allele. | 2012-07-26 |
20120190562 | METHODS AND COMPOSITIONS FOR DETERMINING SEVERITY OF HEART FAILURE IN A SUBJECT - The application provides a method of determining a severity of heart failure in a human test subject, by determining a level of RNA encoded by one or more heart failure marker genes in blood of the test subject compared to controls. | 2012-07-26 |
20120190563 | METHODS FOR PREDICTING SENSITIVITY TO TREATMENT WITH A TARGETED TYROSINE KINASE INHIBITOR - Methods and kits for predicting the sensitivity of a cancer to treatment with a targeted tyrosine kinase inhibitor are disclosed. | 2012-07-26 |
20120190564 | IDENTIFICATION OF PROTEIN BINDING SITES - The disclosure relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular, in relation to protein-protein, protein-nucleic acid, nucleic acid-nucleic acid or biomolecule-ligand interactions. Provided is a synthetic molecular library allowing testing for, identification, characterization, or detection of a discontinuous binding site able to interact with a binding molecule, the library having been provided with a plurality of test entities, each test entity comprising at least one first segment spotted next to a second segment, each segment having the capacity of being a potential single part of a discontinuous binding site. | 2012-07-26 |
20120190565 | Method Of Diagnosis Or Prognosis Of A Neoplasm Comprising Determining The Level Of Expression Of A Protein In Stromal Cells Adjacent To The Neoplasm - The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, EF-I-delta, or M2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm. | 2012-07-26 |
20120190566 | COMPOSITIONS AND METHODS FOR INHIBITING BIOFILMS - Using arrays of peptides derived from | 2012-07-26 |
20120190567 | DIAGNOSTIC AND PROGNOSTIC METHODS FOR LUNG DISORDERS USING GENE EXPRESSION PROFILES FROM NOSE EPITHELIAL CELLS - The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer. | 2012-07-26 |
20120190568 | GENETIC MARKERS ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION, METHODS OF DETECTION AND USES THEREOF - Disclosed is a method for identifying an individual who has an altered risk for developing age related macular degeneration comprising detecting a single nucleotide polymorphism (SNP) | 2012-07-26 |
20120190569 | ENDOGENETIC RETROVIRAL SEQUENCES, ASSOCIATED WITH AUTOIMMUNE DISEASES OR WITH PREGNANCY DISORDERS - A genomic retroviral nucleic material, in an isolated or purified state, at least partially functional or non-functional, wherein the genome comprises a reference nucleotide sequence selected from the group including sequences of SEQ ID NOs: 1-15, their complementary sequences, and their equivalent sequences, in particular, nucleotide sequences having, for every series of 100 contiguous monomers, at least 70% and preferably at least 90% homology with the sequences of SEQ ID NOs: 1-15. | 2012-07-26 |
20120190570 | MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES - The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter “TARGETS”) and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerative and/or inflammatory diseases such as rheumatoid arthritis. | 2012-07-26 |
20120190571 | METHODS AND APPARATUS FOR DETECTION OF GLUTEN SENSITIVITY, AND ITS DIFFERENTIATION FROM CELIAC DISEASE - Antibodies are used as biomarkers to assist in distinguishing gluten immune reactivity and sensitivity, silent celiac disease, Crohn's disease and other gut-related pathologies from classical celiac disease. In one class of embodiments, sera, saliva or other samples from a human or other animal are tested for antibodies to (a) a wheat antigen; (b) a gliadin antigen; and (c) one or more of a wheat germ agglutinin, a gluteomorphin, a glutenin, a deamidated glutenin, a prodynorphin, and a dynorphin. Test results are considered particularly interesting where the wheat antigen and the gliadin antigen are both selected from the group consisting of an α-gliadin-33-mer, an α-gliadin-17-mer, a γ-gliadin-15-mer, an ω-gliadin-17-mer, and a glutenin-21-mer. Test plates and kits can advantageously test for antigens to at least three, five, seven or all of α-gliadin, γ-gliadin, ω-gliadin, glutenin, wheat germ agglutinin, gluteomorphin, prodynorphins, transglutaminase-2, transglutaminase-3, transglutaminase-6, and gliadin-bound transglutaminase. | 2012-07-26 |
20120190572 | DETECTING GENETIC ABNORMALITIES - The present invention is directed to compositions and methods for detecting genetic abnormalities. The present invention encompasses methods and compositions for comparing alleles in a sample containing both maternal and fetal nucleic acids in order to identify genetic abnormalities. | 2012-07-26 |
20120190573 | BIOMARKER OF LUNG CANCER - The present invention provides methods of providing a prognosis for a lung cancer in a subject and methods of predicting the risk of metastasis of a lung cancer in a subject. The present invention additionally provides kits that find use in the practice of the methods of the invention. | 2012-07-26 |
20120190574 | Compound Arrays for Sample Profiling - The invention provides arrays of compound for use in profiling samples. The arrays include compounds bind to components of the samples at relatively low affinities. The avidity of compounds binding to components of the samples can be increased by forming arrays such that multivalent components of the samples (e.g., antibodies or cells) can bind to more than one molecule of a compound at the same time. When a sample is applied to an array under such conditions, the compounds of the array bind to component(s) of the sample with significantly different avidities generating a profile characteristic of the sample. | 2012-07-26 |
20120190575 | INFLUENZA DETECTION METHOD AND KIT THEREFOR - The invention provides oligonucleotide(s) for simple, specific and/or sensitive test(s) for the presence of Influenza A and/or B virus. Kit(s) comprising the oligonucleotide(s) for use as probe(s) and/or primer(s) useful in the test(s) are also provided. | 2012-07-26 |
20120190576 | Glycan Markers as Measure of Disease State of Hepatic Diseases - The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states. | 2012-07-26 |
20120190577 | PROCESSES AND METHODS FOR DIAGNOSIS OF ALZHEIMER'S DISEASE - The present application relates to methods and compositions that can be used to diagnose Alzheimer's disease in mammals, most notably humans. Ti describes most notably peripheral blood biomarkers Alzheimer's disease and uses said biomarkers in diagnostic methods. It also relates to tools and/or kits that can be used to implement said methods (reagents, probes, primers, antibodies, arrays or chips, cells, etc.), as well as the preparation and use thereof. The invention can further be used to detect the presence or the advance of Alzheimer's disease in mammals, including during the disease's early phase, as well as to predict the effectiveness of an Alzheimer's disease treatment. | 2012-07-26 |
20120190578 | Plasma Complement Components as Expression Markers for Age-Related Macular Degeneration and Related Phenotypes - The present invention is directed to systems and method for predicting risk of AMD or a susceptibility to AMD in a patient by detecting elevated serum or plasma levels of C3, CFB or CFH and other complement factor polypeptides, wherein devated levels certain complement factors, genetic risk factors, medical risk factors, behavioral and environmental risk factors are associated with are indicative of susceptibility for or an increased risk of developing AMD, or an increased risk of progression of AMD in the patient. | 2012-07-26 |
20120190579 | Functionalisation of Solid Substrates - The present invention relates to a product comprising a solid substrate and a moiety of formula (I) linked thereto: wherein X, X′ and R are as defined herein. The product is useful for immobilising target molecules such as molecules of biochemical interest to solid substrates for numerous applications, such as affinity chromatography, ELISA, biotechnological assay techniques and solid phase peptide synthesis. | 2012-07-26 |
20120190580 | TREATMENT OF PATIENTS AFTER STENT IMPLANTATION OR BALLOON DILATATION AND DRUG ELUTING STENTS - The present invention relates to a nucleic acid molecule for use in the treatment or preventive treatment of a patient after stent implantation or balloon dilatation, wherein the nucleic acid molecule is selected from (a) a single-stranded nucleic acid molecule comprising or consisting of the sequence of SEQ ID NO: 1, 2, 3 or 4 or a sequence having at least 90% sequence identity to the sequence of SEQ ID NO: 1, 2, 3 or 4; (b) a hairpin RNA, wherein one of the regions forming the double-stranded portion of said hairpin RNA comprises or consists of the sequence of SEQ ID NO: 1, 2, 3 or 4 or a sequence having at least 90% sequence identity to the sequence of SEQ ID NO: 1, 2, 3 or 4; (c) an at least partially double-stranded RNA comprising two separate single strands, wherein a region within one of the strands, said region being located within the double-stranded portion of said double-stranded RNA, comprises or consists of the sequence of SEQ ID NO: 1, 2, 3 or 4 or a sequence having at least 90% sequence identity to the sequence of SEQ ID NO: 1, 2, 3 or 4; (d) a nucleic acid molecule encoding the nucleic acid molecule of (a) or the RNA (b); and (e) a nucleic acid molecule or a two nucleic acid molecules encoding the two separate single strands of the RNA of (c). The present invention also relates to a drug eluting stent comprising the nucleic acid molecule according to the invention. | 2012-07-26 |
20120190581 | Detection of Auto-Antibodies to Specific Glycans as Diagnostic Tests for Autoimmune Diseases - The invention provides uses, methods, and kits for diagnosing an autoimmune disease, particularly scleroderma and systemic lupus erythematosus, in a subject by detecting the presence of one or more antibodies that specifically bind to one or more glycans in a subject sample. | 2012-07-26 |
20120190582 | METHOD FOR DESIGNING PROBE IN DNA MICROARRAY, AND DNA MICROARRAY PROVIDED WITH PROBE DESIGNED THEREBY - Provided is a probe to be used in a DNA microarray having an excellent detection rate of a polymorphism such as SNP contained in genomic DNA. A method for designing a probe according to the invention includes the steps of: specifying one or more regions covering at least a part of fragments flanked by restriction enzyme recognition sites recognized by a restriction enzyme, contained in genomic DNA derived from an organism to be tested; and designing a probe for the specified one or more regions for detecting the fragment in the organism to be tested. | 2012-07-26 |
20120190583 | Combination of Single-Cell Electroporation and Electrical Recording Using the Same Electrode - Methods for stimulating exocytosis from a cell are provided where the same electrochemical microelectrode is used to electroporate an adjacent cell and then measure quantal exocytosis from the adjacent cell. Also provided are methods for stimulating and measuring exocytosis from a select cell population arrayed on a chip comprising addressable electrodes. Calcium independent stimulation of exocytosis with inorganic anions such as chloride ions is also provided. These methods can provide for specific stimulation of a desired subset of cells without exposing other nearby cells to the stimulus. | 2012-07-26 |
20120190584 | Chip assay having improved efficiency - The chip includes electrodes on a substrate. The electrodes include a working electrode, a reference electrode, and a counter electrode. The reference electrode is constructed so as to not have an intrinsic potential. A self-assembly monolayer is positioned on the reference electrode. The self-assembly monolayer includes spacers and active probes. The active probes are configured to have a higher affinity for a capture probe than the spacers have for the capture probe. | 2012-07-26 |
20120190585 | CONCURRENT OPTIMIZATION IN SELECTION OF PRIMER AND CAPTURE PROBE SETS FOR NUCLEIC ACID ANALYSIS - Disclosed is a method of iteratively optimizing two (or more) interrelated sets of probes for the multi-step analysis of sets of designated sequences, each such sequence requiring, for conversion, at least one conversion probe (“primer”), and each converted sequence requiring, for detection, at least one capture probe. The iterative method disclosed herein for the concurrent optimization of primer and probe selection invokes fast logical string matching functions to perform a complete cross-correlation of probe sequences and target sequences. The score function assigns to each probe-target alignment a “degree of matching” score on the basis of position-weighted Hamming distance functions introduced herein. Pairs of probes in the final selection may differ in several positions, while other pairs of probes may differ in only a single position. Not all such positions are of equal importance, and a score function is introduced, reflecting the position of the mismatch within the probe sequence. | 2012-07-26 |
20120190586 | Synthetic Receptors for Identification of Protein Posttranslation Modifications - A method of making a synthetic organic receptor that specifically binds to a modified amino acid is carried out by: reacting a plurality of monomers in a dynamic combinatorial library in the presence of a protein or peptide to form a reaction product, the protein or peptide comprising a modified nucleic acid, with the reacting step carried out under conditions in which at least one oligomer that specifically binds to the modified amino acid is selectively amplified in the reaction product; and then isolating or identifying from the reaction product at least one oligomer that specifically binds to the modified amino acid. | 2012-07-26 |
20120190587 | Global Amplification Using A Randomly Primed Composite Primer - The invention relates to the field of polynucleotide amplification. More particularly, the invention provides methods, compositions and kits for amplification of (i.e., making multiple copies of) a multiplicity of different polynucleotide template sequences using a randomly primed RNA/DNA composite primer. | 2012-07-26 |
20120190588 | Methods for Identifying Agents that Inhibit Cell Migration, Promote Cell Adhesion and Prevent Metastasis - Disclosed are methods for identification of agents that modulate cell attachment, cell migration and cell viability. Cancer and primary cells adhered to a matrix are treated with agent(s) that modulate ActRII signaling and cell adhesion. Agents are tested that modulate cell adhesion, detachment, invasion and viability. Agents that modulate the expression, phosphorylation, function and translocation of ActRII signaling pathway members also can predict agents that modulate cell adhesion, detachment, invasion and viability. The methods have utility in identifying agents that prevent cancer cell metastasis, wound dehiscence, aortic dissection and aid retina attachment and skin replacement and fertility. | 2012-07-26 |
20120190589 | Assay Cartridges and Methods of Using the Same - Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge. | 2012-07-26 |
20120190590 | Assay Plates, Reader Systems and Methods for Luminescence Test Measurements - Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence. | 2012-07-26 |