30th week of 2013 patent applcation highlights part 44 |
Patent application number | Title | Published |
20130190141 | Arm Exerciser for a Foot Pedal Operated Cycle - A bicycle handle with a resistance mechanism is provided such that the combination of the force that the user provides and that the resistance mechanism provides is a zero force directed towards steering the bicycle. The user provides a force on the bicycle handle which in turn overcomes the resistance mechanism to provide linear movement. A repetition of this movement provides a means of strengthening or maintaining the muscle tone of the user's upper body while they are riding the bicycle, thus providing a means of simultaneous exercise for the user's upper and lower body and back. | 2013-07-25 |
20130190142 | ABDOMINAL EXERCISING APPARATUS - An exercising apparatus for exercising muscles in the abdominal region of a user's body may include a stationary primary body support configured to support upper portions of the user's body including the abdominal region. The primary body support may include a primary body support surface oriented to support a user's back in a rearwardly inclined position and a secondary body support surface for supporting the user's buttocks. A movable carriage may be configured to be engaged by the user's lower leg portions and may be movable along a substantially linear path extending generally toward and generally away from the secondary body support surface. A resistance application assembly may be configured to apply an adjustable degree of biasing force to the carriage in a direction generally away from the secondary body support surface to resist movement of the carriage toward the secondary body support surface. | 2013-07-25 |
20130190143 | SPOTTING DEVICE - A spotting device for use during exercise routines is provided where a lineal motor includes a forcer that travels along a magnetic shaft to provide a resistance force in response to a force generated by a weight in order to provide assistance and safely to a user performing the exercise routine. | 2013-07-25 |
20130190144 | Weighted Vest - A sports vest for fitness training provides body-centered resistance for endurance, agility, and strength training. The vest has a V-shaped front neoprene panel, and a generally identical back neoprene panel. A plurality of auxiliary pockets holds weights along the legs of the each panel. A triangular central pocket hold weights just above the rounded V point on each panel. Interior partitions within the pockets prevent the weights from shifting. Straps secure the vest to a fitness trainee. The vest shape, arrangement of weights, and weight partitions generally maintains a trainee's center of gravity and balance in executing exercise movements. | 2013-07-25 |
20130190145 | Dynamic Weight Training Apparatus - A dynamic weight training apparatus is disclosed herein for improved calorie burning and muscle toning. The weight training apparatus generally includes a pendulum mass suspended, e.g., via a flexible shaft, from a handle or other securing mechanism. A user swings the weight in a pendulum motion when exercising (walking, jogging, stationary, sitting or standing) providing for increased resistance. A flexible shaft may advantageously dampen/reduce shock and strain associated with the pendulum motion. | 2013-07-25 |
20130190146 | PORTABLE EXERCISE DEVICE AND METHOD OF USING THE SAME - According to one embodiment, an exercise device in the form of an adjustable resistance multi-use toning system that includes a plurality of elongated elastic bands (tension bands or cables) which can have different tension (resistance) values. Each band has a first end and an opposing second end. The device further includes a hollow sleeve that receives at least a portion of each of the elastic bands so as to at least partially envelope the elastic bands while permitting the first and second ends to be accessible. A first fastener is provided for attaching the first ends of the elastic bands to a support member, such as a piece of exercise equipment, a belt to be worn around a body part of a user; or any other structure to which the exercise device can be attached. | 2013-07-25 |
20130190147 | INTEGRATOR FOR GLOBAL ELASTIC MOTION MODE OF HUMAN BODY - An integrator for global elastic motion mode of human body comprises an elastomer ( | 2013-07-25 |
20130190148 | Strength Training System and Method Having Elastic Resistance and Suspension Devices - A strength training system and method includes an inelastic base strap connecting with an anchor and connecting with elastic/static components, which in turn are connected with handles. The combination of an inelastic base strap with modular elastic/static components configurable to be either elastic or inelastic provides the ability to perform suspension training as well as elastic band training with the same system. The elastic/static components may quickly be converted from an elastic to an inelastic segment by simply disconnecting the elastic module or by simply connecting the inelastic segment, since it is shorter than the elastic module. The elastic module includes a plurality of connectable elastic bands and may easily be replaced with other modules. An anchor point device is disclosed having double opposing cam buckles, usable with a door. | 2013-07-25 |
20130190149 | Abs Device - The invention delivers a comfortable effective exercise apparatus. Designed to engage sculpt and isolate upper/lower abdominal muscles the devise operates as such; user adjust length of forward/ rear T(respectively). Seat is adjusted to accommodate user. Next, the cable system is adjusted to body length and resistance is set using spring or rubber couplets. User mounts apparatus feet under foot bar executing a sit-up using cables creating resistance shifting body weight to engage various abdominal muscles. | 2013-07-25 |
20130190150 | Exercise apparatus for accommodating push-ups - The present invention provides for an exercise apparatus for assisting in performing a push-up exercise. The apparatus includes a base with a convex outer surface connected to the handle support structure and a handle. The convex outer surface of the base of the apparatus provides a user with a means to engage muscle groups not normally exercised during a conventional push-up exercise, through the action of continuously stabilizing their weight on the apparatus, and by providing a means to rotate the wrists during the exercise. The apparatus also provides a user with a means to perform the exercise at different widths and positions during the exercise, by repositioning (sliding or moving) the apparatus during the exercise, on an appropriate surface. The apparatus is also intended to be lightweight and compact enough to be transportable for activities such as jogging or running. | 2013-07-25 |
20130190151 | KINESIOLOGICAL SUPPORT SYSTEM AND METHOD OF USE - A kinesiological support system for supporting at least one portion of the human body above a base surface. The kinesiological support system including a body. The body includes a tactile surface and a contact surface. The tactile surface is configured to provide an elliptical contact with the at least one portion of the human body. The center of the body and the tactile surface define at least a portion of an ellipse. The contact surface is configured to provide an elliptical path of motion to the body relative to the base surface. | 2013-07-25 |
20130190152 | MULTISPINDLE MACHINING CENTER - A multispindle machining center includes a machine body, a knife rack, and a plurality of spindles. The knife rack has a knife rack body, a plurality of knife claws and a plurality of knife holders. The knife rack body has a plurality of accommodating troughs and accommodating trough openings connecting the accommodating troughs to the outside. The knife claw has a knife claw trough penetrating the top and bottom of the knife claw, and the knife claw opening connects the knife claw trough to the outside. The knife holder has a spindle connecting end and knife connecting end. The size and shape of the spindle connecting end is the same, while the size and shape of the knife connecting end vary. The outer periphery of the knife holder has a clipping portion which can be forced into the knife claw trough from the knife claw opening in a detachable way. | 2013-07-25 |
20130190153 | AUTO CHANGER SPINDLE MOUNTING ASSEMBLY - An apparatus and method for machining is provided. A mounting assembly for use with a spindle, a CNC machine, an auto changer device and an air supply line, can include a mounting collar and a mounting block. The mounting collar can have a collar body and a collar arm, where the collar body defines a collar opening and one or more grooves circumscribing the collar opening, where the one or more grooves each have a sealing element positioned therein, and wherein the collar arm has a collar inlet, a collar outlet and a collar channel to provide fluid communication between the collar inlet and the collar outlet. The mounting block can be connected to the CNC machine and can have a block inlet connected to the air supply line, a block outlet, and a block channel to provide fluid communication between the block inlet and the block outlet. | 2013-07-25 |
20130190154 | PAPERBOARD-BASED BEVERAGE CONTAINER - A container including at least one wall that defines an internal volume and an opening into the internal volume, the wall defining an internal surface and an external surface and being formed as a layered structure that includes a first layer, a second layer that includes paperboard and defines the external surface, and an adhesive layer disposed between the first layer and the second layer, wherein at most 0.15 grams of surface condensation forms on the wall per 300 square centimeters of the external surface during a 20-minute interval, the 20-minute interval beginning upon filling 75 percent of the internal volume with a liquid maintained at a temperature of about 32° F. while the filled container is exposed to an ambient temperature of about 73° F. and about 50 percent relative humidity. | 2013-07-25 |
20130190155 | Method and Apparatus For Making Bags - A machine and method for making bags is described and includes a web traveling from an input section to a rotary drum, to an output section. The drum includes at least one seal bar, having a first sealing zone and an adjacent weakening zone. The weakening zone may be a heated perforator, heating wire, and/or may create an auxiliary sealed area. The heating wire is powered by a source of power at an adjustable voltage or magnitude, and/or pulsed, and/or with a feedback loop. The heating wire may make intermittent contact with the web and/or be disposed in an insert. The weakening zone may create a line of weakness that is uniform or varies in intensity, is a separating zone. The sealing zones may include temperature zones, cartridge heaters, cooling air, or heated air, or a source of ultrasonic, microwave or radiative energy. | 2013-07-25 |
20130190156 | FASTENING TOOL - A fastening tool can be held by a single hand and can obviate the necessity of application of strong force when fastening sheets of paper together. The fastening tool has a construction in which a placing table configured to move only in a vertical direction is provided at an inner upper portion of a base member, a paper holding member configured to move in a vertical direction is disposed above the placing table, a handle member is mounted on the base member so as to rotate relative thereto about a position lying near a rear end thereof, and a portion of the handle member which lies inside and further rearwards than a central portion of the handle member is formed into a pressing portion, whereby an upper surface of a rear portion of the paper holding member is pressed down directly by the pressing portion. | 2013-07-25 |
20130190157 | FABRIC FASTENING METHOD AND DEVICE FOR CARRYING OUT THE SAID METHOD - The cloth of different size and form is fixed on a surface, fastening elements are fixed in the body of the cloth preventing their movement along the cloth, the fastening elements are chosen considering the need for multiple folding and prompt fastening of fastening elements in the folded position. A fastening element is folded lengthwise along the rectangular edge of the surface at a 90° angle, then folded again at a 90° angle. In another embodiment a fastening element is folded crosswise along rounded edge of the surface, the edge of the fastening element, after going round the surface, should be adjacent the inner side of the surface. In another embodiment a fastening element is folded crosswise along figured edge of the surface repeating its form, the edge of the fastening element after folding along the edge of the surface, should be adjacent the inner side of the surface. | 2013-07-25 |
20130190158 | Method And Apparatus For Folding A Web - A web has a series of cut outs that define bridging portions therebetween. A method for folding the web includes providing the web to a first conveyor, folding the web about a folding wheel to define a folded edge that extends through the series of cut outs, transferring the web to a second conveyor having an included angle of 15 to 40 degrees in relation to the first conveyor, folding the web about a folding bar to maintain the folded edge, and spanning at least one cut out with the folding bar and contemporaneously contacting at least two bridge portions with the folding bar to maintain the folded edge of the web about the folding bar as the web passes the folding wheel edge. | 2013-07-25 |
20130190159 | CENTRIFUGE - A centrifuge capable of suppressing a long-time depressurization as compared with the case of starting depressurizing after cooling has been completed as well as shortening a cooling time of a rotor and a sample in the rotor is achieved as compared with the case of starting cooling is at the same time with depressurization. Operation of a Peltier element is started at the same time with operation start of the centrifuge. A bowl is cooled by heat absorption of the Peltier element, and the rotor is cooled by the bowl with using ambient air as a thermal medium. At this time, a vacuum pump depressurizing a rotor chamber is in an OFF state (ambient conditions). After a predetermined time is elapsed, the vacuum pump is turned on to start depressurization of the inside of the rotor chamber. | 2013-07-25 |
20130190160 | DECANTER-TYPE CENTRIFUGAL SEPARATOR EQUIPPED WITH CONTINUOUS LUBRICANT SUPPLY DEVICE - A decanter-type centrifugal separator equipped with a continuous lubricant supply device capable of preventing leakage of lubricating oil along supply pathways, and supplying and discharging lubricating oil. The continuous lubricant supply device has a lubricating oil supply channel formed inside a bowl hub, an annular introduction channel that introduces lubricating oil into the lubricating oil supply channel, a lubricating oil infusion channel formed inside a holder, and an oil collector installed on an outer surface of an outer shaft. The annular introduction channel has a first annular groove formed inside the holder such that the groove is occluded on the inside by the outer surface of the outer shaft. The oil collector can orbitally revolve in a predetermined direction inside the annular introduction channel, thereby moving lubricating oil radially inward in the annular introduction channel so as to flow into the lubricating oil supply channel. | 2013-07-25 |
20130190161 | Vibration Response and Tuning of a Center of Mass/Gravity of a Centrifuge - Centrifuges have been designed in the past for centrifuging multi-welled containers, but they are limited in centripetal acceleration or have a large footprint. The invention provides a centrifuge with a high centripetal acceleration and imbalance tolerance while maintaining a small footprint and being able to integrate with laboratory automation equipment. Methods and apparatuses for centrifugation include a rotor assembly positioned within a shield assembly suspended in a centrifuge. The rotor assembly is operably connected to the motor for rotating payloads (e.g., multi-welled containers) around an axis. The shield assembly is positioned such that the center of mass is aligned with the axis of rotation of the rotor assembly and the plane containing the rotational imbalance force vector. This alignment allows rotation of the container with an acceleration of at least | 2013-07-25 |
20130190162 | OPTICAL GLASS AND OPTICAL ELEMENT - The invention discloses an optical glass and an optical element. The optical glass comprises 0.1 wt %-8 wt % of SiO | 2013-07-25 |
20130190163 | DIELECTRIC CERAMIC AND ELECTRONIC COMPONENT USING THE SAME - A dielectric ceramic contains Mg | 2013-07-25 |
20130190164 | SINTERED ZIRCONIA, AND COMPOSITION FOR SINTERING AND CALCINED BODY THEREFOR - A sintering composition and calcined object which are precursors for a sintered zirconia. The burned surface of the sintered zirconia gives an X-ray diffraction pattern in which the ratio of the height of the peak present around the location where a [200] peak assigned to the cubic system is to appear to the height of the peak present around the location where a [200] peak assigned to the tetragonal system is to appear is 0.4 or more, and a region located at a depth of 100 μm or more from the burned surface gives an X-ray diffraction pattern in which the ratio of the height of the peak present around the location where a [200] peak assigned to the cubic system is to appear to the height of the peak present around the location where a [200] peak assigned to the tetragonal system is to appear is 0.3 or less. | 2013-07-25 |
20130190165 | CHEMICALLY BONDED CERAMICS BASED ON FLY ASH - Chemically bonded ceramics and manufacturing processes are described. In one aspect, a manufacturing process of a chemically bonded ceramic is carried out by: (1) combining an acidic liquid and Fly ash to form a mixture; and (2) curing the mixture to form the chemically bonded ceramic. The Fly ash corresponds to at least a majority by weight of solids combined with the acidic liquid to form the mixture. | 2013-07-25 |
20130190166 | NOx REDUCTION CATALYST FOR EXHAUST GAS AND METHOD FOR PRODUCING SAME - To provide a catalyst having excellent performance and durability by improving a NOx reduction ratio at 350° C. or higher without deteriorating excellent durability of a Ti—V—Mo—P catalyst in view of problems of conventional art. A NOx reduction catalyst for exhaust gas, which is composed of a catalyst composition that comprises titanium (Ti), an oxide of phosphorous, molybdenum (Mo) and/or tungsten (W), oxide of vanadium (V), and high-silica zeolite that has an SiO | 2013-07-25 |
20130190167 | METHOD TO MAKE AN ACIDIC IONIC LIQUID CATALYST HAVING GREATER THAN 20 WT% CONJUNCT POLYMER - A method to make an acidic ionic liquid catalyst comprising:
| 2013-07-25 |
20130190168 | Methods Of Synthesizing Hydrous Zirconium Oxide And Other Oxides - The present invention relates to sol gel hydrous metal oxide particles, such as hydrous zirconium oxide particles, their manufacture, and their use in such applications as sorbent dialysis. | 2013-07-25 |
20130190169 | SYNERGISTIC FUNGICIDAL COMBINATION - Compositions and methods employing combinations of synergistically effective amounts of folpet and epoxiconazole are provided. | 2013-07-25 |
20130190170 | WHEAT PLANTS HAVING INCREASED RESISTANCE TO IMIDAZOLINONE HERBICIDES - The present invention is directed to wheat plants having increased resistance to an imidazolinone herbicide. More particularly, the present invention includes wheat plants containing one or more IMI nucleic acids such as a Gunner IMI 205, Gunner IMI 208 and Madsen IMI cultivar. The present invention also includes seeds produced by these wheat plants and methods of controlling weeds in the vicinity of these wheat plants. | 2013-07-25 |
20130190171 | MESOIONIC PYRIDO [1, 2-A] PYRIMIDINE PESTICIDES - Disclosed are compounds of Formula 1, | 2013-07-25 |
20130190172 | NEMATOCIDAL SULFONAMIDES - Disclosed are compounds of Formula 1, N-oxides, and salts thereof, | 2013-07-25 |
20130190173 | ELECTROCHEMICALLY TREATED NUTRIENT SOLUTIONS - The invention relates to nutrient compositions for agricultural applications, and methods for plant or crop growth and care. The nutrient composition comprises a potassium-based nutrient solution enriched by electrochemical treatment. In various embodiments, the potassium-based nutrient composition comprises hypochlorous acid. The present invention involves the use of the nutrient compositions or solutions, among other things, in pre-harvest and post-harvest treatments and in environmental and soil disinfection. | 2013-07-25 |
20130190174 | Vegetation Treatment - A method is provided for inhibiting plant growth by inducing hypothermia by applying a treating substance to summer annual weeds and grasses. Susceptible undesirable plants will be killed by this treatment, while non-susceptible desirable plants will not be adversely affected by this treatment. Compressed carbon dioxide may be applied to other summer grasses to cause the grasses to become dormant. An apparatus is provided for inducing hypothermia in undesirable plants by applying a treating substance. A canister capable of housing gas may be provided. A valve may be provided to control the amount and pressure of gas dispensed from the canister. | 2013-07-25 |
20130190175 | USES OF THAXTOMIN AND THAXTOMIN COMPOSITIONS AS HERBICIDES - There is a need for a selective, low-risk herbicide that can be used to control weeds in cereal cultures and turf. The present invention discloses that a bacterial secondary metabolite, thaxtomin and optionally another herbicide is an effective herbicide on broadleaved, sedge and grass weeds. Thaxtomin A and structurally similar compounds can be used as natural herbicides to control the germination and growth of weeds in cereal, turf grass, Timothy grass and pasture grass cultures with no phytotoxicity to these crops. As a natural, non-toxic compound, thaxtomin can be used as a safe alternative for weed control in both conventional and organic farming and gardening systems. | 2013-07-25 |
20130190176 | SOLID HERBICIDE COMPOSITIONS WITH BUILT-IN ADJUVANT - The present disclosure concerns improved solid herbicidal compositions, such as granules and powders, containing built-in adjuvant, which have improved stability and exhibit acceptable herbicidal efficacy when used to control weeds in flooded rice paddies or fields, or cereal crop fields. | 2013-07-25 |
20130190177 | AGRICULTURAL AGENT CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT - Disclosed herein is an agricultural agent containing a 2,5-diketopiperazine derivative capable of controlling plant diseases and promoting plant growth or an agriculturally acceptable salt thereof as an active ingredient. | 2013-07-25 |
20130190178 | Pesticidal Treatment Compositions - The pesticidal compositions comprising synergistic mixtures of O,O-dimethyl S-phthalimidomethyl phosphorodithioate or suitable salt forms thereof, and at least one benzoylurea based chitin inhibiting compound or suitable salt forms thereof, and especially preferably one or more of (RS)-1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6-di-fluorobenzoyl)urea (also interchangeably referred to as “novaluron”) or suitable salt forms thereof, and 1-(2-chlorobenzoyl)-3-(4-trifluoromethoxyphenyl)urea (also interchangeably referred to as “triflumuron”) or suitable salt forms thereof, for the control of undesired pests, preferably for the control of Codling moths in fruit. Methods of controlling the incidence of undesired pests, via treatment regimens providing synergistic amounts of each of the foregoing compounds, are also disclosed. | 2013-07-25 |
20130190179 | USE OF ALS INHIBITOR HERBICIDES FOR CONTROL OF UNWANTED VEGETATION IN ALS INHIBITOR HERBICIDE TOLERANT BETA VULGARIS PLANTS - The present invention relates generally to the use of biological or chemical control agents with for controlling insects and nematodes and to methods particularly useful for combating insects or nematodes and/or increasing crop yield in plants that are at least partially resistant to one or more parasitic nematodes or insects. | 2013-07-25 |
20130190180 | WHEAT PLANTS HAVING INCREASED RESISTANCE TO IMIDAZOLINONE HERBICIDES - The present invention is directed to wheat plants having increased resistance to an imidazolinone herbicide. More particularly, the present invention includes wheat plants containing one or more IMI nucleic acids such as a Gunner IMI 205, Gunner IMI 208 and Madsen IMI cultivar. The present invention also includes seeds produced by these wheat plants and methods of controlling weeds in the vicinity of these wheat plants. | 2013-07-25 |
20130190181 | SYNERGISTIC BLENDS OF (ALKYL) NAPHTHALENE FORMALDEHYDE CONDENSATE SULFONATES AND LIGNOSULFONATES USEFUL IN AGROCHEMICAL FORMULATIONS - The invention generally relates to a synergistic co-spray dried blend of (alkyl) naphthalene formaldehyde condensate sulfonates and lignosulfonates. This co-spray dried blend is useful as a dispersant in useful in agrochemical formulations. | 2013-07-25 |
20130190182 | SUPER-CONDUCTIVE TUBE USED FOR A DISCHARGE DEVICE - A super-conductive tube used for a discharge device is formed integrally by a super-conductive material. The super-conductive tube is a hollow tube formed by a front end surface, a rear end surface, an inner tube wall and an outer tube wall. An interior of the super-conductive tube is formed with a hollow space and an interior of the hollow space is in a vacuum state. The inner tube wall and the outer tube wall are formed by extending the front end surface toward the rear end surface and an end of the outer tube wall is extended with a guide portion toward the discharge device. Accordingly, when the super-conductive tube is applied to a discharge device, electrical energy will be generated by the super-conductive tube through a magnetic field that results from an operation of electric current, after the discharge device has released electric energy. | 2013-07-25 |
20130190183 | ARRANGEMENT WITH A SUPERCONDUCTIVE ELECTRICAL DIRECT CURRENT CABLE SYSTEM - An arrangement with a superconductive electrical direct current cable system is specified which includes at least one direct current transmission element ( | 2013-07-25 |
20130190184 | DEVICE AND METHOD FOR DAMPED, NON-CONTACT SUPPORT OF A COOLANT FEED LINE FOR SUPERCONDUCTING MACHINES - A superconducting machine for supporting a coolant feed line for superconducting machines includes a hollow shaft that can be connected to the superconducting machine in a first region, the coolant feed line being disposed in the interior thereof for feeding the coolant from the refrigeration unit to the superconducting machine. A magnetic support is disposed in the first region of the hollow shaft so that a radial and thus motion-damping, centering force is exerted on the coolant feed line. The magnetic support has a first and a second magnetic cylinder, wherein the first magnetic cylinder is disposed on the outer jacket of the coolant feed line and the second magnetic cylinder is disposed on the inner face of the hollow shaft. The first magnetic cylinder is a cylinder made of highly electrically conductive material having ohmic resistance. | 2013-07-25 |
20130190185 | SYSTEMS, METHODS AND APPARATUS FOR PLANAR EXPULSION SHIELDS - A superconducting magnetic shielding system includes first and second planar superconducting shields respectively positioned above and below an environment to be shielded. The shields are each thermally coupled to a cold source at a respective thermalizing point. When the shields are cooled into the superconducting regime, they passively block magnetic fields via the Meissner Effect. Each shield may also be shaped to produce a smooth temperature gradient extending away from its thermalizing point; thus, as the shields are cooled, magnetic fields may be expelled away from the thermalizing point and, consequently, away from the environment to be shielded. A heater may also be provided opposite the thermalizing points to improve control of the temperature gradient. | 2013-07-25 |
20130190186 | SUPERCONDUCTING MAGNET DEVICE AND MAGNETIC RESONANCE IMAGING SYSTEM - A superconducting magnet device and a magnetic resonance imaging system not only avoid the need for costly aluminum alloy formers but also lower quench pressure effectively, have a baffle covering the former and the coil, with a gap between the baffle and the coil. | 2013-07-25 |
20130190187 | FAST-CYCLING, CONDUCTION-COOLED, QUASI-ISOTHERMAL, SUPERCONDUCTING FAULT CURRENT LIMITER - Fault Current Limiters (FCL) provide protection for upstream and/or downstream devices in electric power grids. Conventional FCL require the use of expensive conductors and liquid or gas cryogen handling. Disclosed embodiments describe FCL systems and devices that use lower cost superconductors, require no liquid cryogen, and are fast cycling. These improved FCL can sustain many sequential faults and require less time to clear faults while avoiding the use of liquid cryogen. Disclosed embodiments describe a FCL with a superconductor and cladding cooled to cryogenic temperatures; these are connected in parallel with a second resistor across two nodes in a circuit. According to disclosed embodiments, the resistance of the superconducting components and its sheath in the fault mode are sufficiently high to minimize energy deposition within the cryogenic system, minimizing recovery time. A scheme for intermediate heat storage also is described which allows a useful compromise between conductor length enabled energy minimization and allowable number of sequential faults to enable an overall system design which is affordable, and yet allows conduction cooled (cryogen free) systems which have fast recovery and allows for multiple sequential faults. | 2013-07-25 |
20130190188 | METHOD OF MANUFACTURING BASE MATERIAL FOR SUPERCONDUCTING CONDUCTOR, METHOD OF MANUFACTURING SUPERCONDUCTING CONDUCTOR, BASE MATERIAL FOR SUPERCONDUCTING CONDUCTOR, AND SUPERCONDUCTING CONDUCTOR - A method for manufacturing a base material | 2013-07-25 |
20130190189 | IN VITRO SORTING METHOD - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention. | 2013-07-25 |
20130190190 | MOLECULAR TARGETS FOR MODULATING INTRAOCCULAR PRESSURE AND DIFFERENTIATION OF STEROID RESPONSES VERSUS NON-RESPONDERS - Molecular biomarkers as indicators of responses to steroids, drug targets, predictors of steroid responses and identification of drugs for modulating intraocular pressure. Kits and methods of identifying and distinguishing between steroid responders and non-responders. | 2013-07-25 |
20130190191 | MINIATURIZED, HIGH-THROUGHPUT NUCLEIC ACID ANALYSIS - The present invention is directed to method for analyzing multiple nucleic acid molecules of interest comprising in the steps of (i) providing a plurality of beads, characterized in that each bead comprises at least two sequence specific amplification primers, further characterized in that at least one of the primers is bound to the bead via a cleavable linker, (ii) capturing the nucleic acid molecules of interest from a sample, (iii) clonally isolating the plurality of beads, (iv) cleaving the at least one primer, (v) clonally amplifying the nucleic acid thereby creating multiple amplification products, and (vi) analyzing the amplification products. | 2013-07-25 |
20130190192 | Methods And Systems For Long Distance Tagging, Tracking, And Locating Using Wavelength Upconversion - Methods and systems for plasmonically enhanced bionanoantennas for tagging, tracking, and locating targets of interest at long distances in both day and nighttime conditions. The nanoantennas are used to tag a target of interest and emit a wavelength to impart a unique biometric signature. The nanoantennas are detectable by selectively harvesting and plasmonically enhancing incident light in the visible region, then upconverting that energy through an activated phosphor. | 2013-07-25 |
20130190193 | COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDES USING LIGHT HARVESTING MULTICHROMOPHORES - Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. The sensor PNA comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided. | 2013-07-25 |
20130190194 | DETERMINATION OF GENE EXPRESSION LEVELS OF A CELL TYPE - Methods, systems, and compositions can determine gene expression level of a specified cell-type subpopulation by direct analysis of a cell mixture sample composed of multiple subpopulations of various cell-types without the need of prior separation of the component cell-type subpopulations. A target gene and a reference gene can be identified as being informative for a specific cell-type subpopulation when at least 50% of the gene's transcripts in the cell mixture are from the subpopulation. This relative expression level in the cell mixture of the informative target and reference genes can correlate to the relative expression when measured in the isolated subpopulation. Thus, a similar biomarker can be obtained without the difficult step of isolating the cells of the subpopulation. | 2013-07-25 |
20130190195 | NUCLEIC ACID DETECTION BY BRIDGE AMPLIFICATION ON CODED PARTICLES - Particles that generate electromagnetic spectra upon appropriate illumination and in which the spectra can be converted to codes that reflect differences in the spectra are functionalized with a plurality of identical primer pairs on which bridge amplification can be performed. Using these particles, nucleic acids in a biological sample are amplified and exposed to a label that sends a signal only when bound to double-stranded DNA. The code for each particle is correlated with the primer pairs, and the captured nucleic acids are thus detected and identified. The procedure is useful for multiplex DNA or RNA detection as well as counting of target DNA and RNA molecules in the sample. | 2013-07-25 |
20130190196 | RAPID PHENOTYPIC DIAGNOSIS OF PATHOGENS AND DRUG RESISTANCE USING TRANSCRIPTIONAL EXPRESSION SIGNATURES - The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects. | 2013-07-25 |
20130190197 | METHOD OF PROFILING GENE EXPRESSION IN A SUBJECT HAVING COLORECTAL CANCER - The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen. | 2013-07-25 |
20130190198 | METHOD FOR AUTOMATED TISSUE ANALYSIS - The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the ‘systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions. | 2013-07-25 |
20130190199 | Methods of Analysis of Allelic Imbalance - Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to an array designed to interrogate individual alleles. Genes whose transcription products are present in amounts that vary from expected are candidates for allelic imbalance, imprinting and imprinting errors. | 2013-07-25 |
20130190200 | SNP FOR PREDICTING THE SENSITIVITY TO ANTICANCER TARGETED THERAPEUTIC FORMULATION - The present invention relates to a single nucleotide polymorphism (SNP) for predicting the sensitivity to an anticancer targeted therapeutic formulation, a polynucleotide containing the same, and a method for predicting the sensitivity to an anticancer targeted therapeutic formulation. According to the present invention, it is possible to predict the sensitivity of each individual to a certain anticancer targeted therapeutic formulation, using a small amount of a sample taken from a patient and thus to select a most suitable targeted therapeutic formulation over the entire duration of treatment for the patient. | 2013-07-25 |
20130190201 | DETECTION OF HUMAN UMBILICAL CORD TISSUE DERIVED CELLS - The invention relates to methods for detecting allogeneic therapeutic cells (such as human umbilical cord tissue-derived cells (hUTC)) in blood. The methods includes the steps of identifying one or more one or more markers positive for allogeneic therapeutic cells (e.g. hUTC) and one or more markers positive for human peripheral blood mononuclear cells (PBMC); providing a blood sample from a patient that has been treated with allogeneic therapeutic cells (e.g. hUTC), analyzing the sample using an assay method to detect one or more markers positive for PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC); and distinguishing between the PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC). In one embodiment, the cells are hUTC and the markers positive of hUTC include CD10 and/or CD13 and the one or more markers positive for PBMC includes CD45. | 2013-07-25 |
20130190202 | DEVICES AND PROCESSES FOR ANALYSING INDIVIDUAL CELLS - A device for individually analysing cells of interest, comprising (a) a channel for receiving the contents of a cell of interest, wherein the channel has an input end and an output end, and (b) a cell trapping site in proximity to the input end of the channel, wherein (i) the input end of the channel is adapted such that an intact cell of interest cannot enter the channel; and (ii) the channel contains one or more analytical components for analysing the contents of the cell of interest. In use, a cell is applied to the device, where it is trapped by the cell trapping means. The cell cannot enter the channel intact, but its contents can be released in situ to enter the channel's input end. The contents can then move down the channel, towards the output end, and they encounter the immobilised reagents, thereby permitting analysis of the cell contents. | 2013-07-25 |
20130190203 | Reporting And Self-Decontaminating Articles For Individual Hazard Detection And Protection - Methods, systems, and devices for the self-detection and/or self-decontamination of chemical, biological, radiological, and/or nuclear hazards, threats, and contaminants. The self-detection system preferably uses aptamers functionalized to an electronic system to sense CBRN threats. The aptamers are functionalized directly to a conductive surface such as a noble metal coated fiber or other conductive fiber strand. The self-decontamination system is preferably in communication with the self-detection system and responds to the detection of a CBRN agent by switching to a decontamination state, such as becoming absorbent or releasing an anti-CBRN agent such that it can neutralize the threat. In a preferred embodiment, the system is worn by a user. | 2013-07-25 |
20130190204 | MONOCLONAL ANTIBODIES AGAINST PCBP-1 ANTIGENS, AND USES THEREFOR - The present invention provides and includes monoclonal antibodies (MoAbs or mAbs) specific or preferentially selective for PCBP-1 antigens, hybridoma lines that secrete these PCBP-1 antibodies or antibody fragments, and the use of such antibodies and antibody fragments to detect PCBP-1 antigens, particularly those expressed by cancer cells. The present invention also includes antibodies that are specific for or show preferential binding to a soluble form of PCBP-1. The present invention further includes chimeric and humanized antibodies, processes for producing monoclonal, chimeric, and humanized antibodies using recombinant DNA technology, and their therapeutic uses, particularly in the treatment of cancer. The present invention further includes methods and kits for the immunodetection and immunotherapy of cells for samples which express PCBP-1 antigens. | 2013-07-25 |
20130190205 | METHOD FOR DETECTING CYTOSINE METHYLATION IN DNA SAMPLES - Described is a method for detecting 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, 5-methylcytosine and cytosine reacting differently, and the pretreated DNA is subsequently amplified using a polymerase and at least one primer. In the next step, the amplified genomic DNA is hybridized to at least one oligonucleotide, forming a duplex, and said oligonucleotide is elongated by at least one nucleotide, the nucleotide carrying a detectable label, and the elongation depending on the methylation status of the specific cytosine in the genomic DNA sample. In the next step, the elongated oligonucleotides are analyzed for the presence of the label. | 2013-07-25 |
20130190206 | Direct Clone Analysis and Selection Technology - The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e., millions-billions) but with greater efficiency and shorter time. | 2013-07-25 |
20130190207 | PRIORITISED GENETIC POLYMORPHISMS AND MIGRAINE SUSCEPTIBILITY - The invention provides identification of an increased risk of or a predisposition to migraine according to the presence of one or more polymorphisms in the adenosine deaminase, RNA-specific, B2 (ADARB2) gene in the nucleic acid complement of a subject. | 2013-07-25 |
20130190208 | DETECTION OF TARGET NUCLEIC ACID SEQUENCES BY EXONUCLEOLYTIC ACTIVITY USING SINGLE-LABELED IMMOBILIZED PROBES ON SOLID PHASE - The present invention relates to a novel method for detection of target nucleic acid sequences by cyclic exonucleolytic reactions (CER) or exonucleolytic reactions (ER) using single-labeled immobilized probes on a solid phase. The present invention enables to detect target nucleic acid sequences on a solid phase using single-labeled systems. Comparing with multiple-labeled systems such as dual labeling, the present invention using single-labeled probes has excellent advantages in light of convenience and cost effectiveness in probe design and preparation. Furthermore, the measurement of changes of the signal decrease during reactions is responsible for more accurate qualitative and quantitative analysis of target nucleic acid sequences. | 2013-07-25 |
20130190209 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 2013-07-25 |
20130190210 | ENGINEERED TISSUES FOR IN VITRO RESEARCH USES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME - Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays. | 2013-07-25 |
20130190211 | TITANIUM NITRIDE AS SENSING LAYER FOR MICROWELL STRUCTURE - A method of fabricating a microwell in an array structure is disclosed herein. The array structure can include a plurality of field effect transistors (FETs), where each FET has a gate structure. The method can include disposing a titanium nitride (TiN) layer on at least one conductive layer coupled to the gate structure of at least one FET. A insulation layer can also be disposed on the array structure, where the insulation layer lies above the TiN layer. Further, an opening above the gate structure of the at least one FET can be etched to remove the insulation layer above the gate structure and to expose the TiN layer. A microwell with at least one sidewall formed from the insulation layer and with a bottom surface formed from the TiN layer is a result of the etching process. | 2013-07-25 |
20130190212 | CELL CAPTURE SYSTEM AND METHOD OF USE - A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber. | 2013-07-25 |
20130190213 | Microfluidic Methods, Devices, and Systems for Fluid Handling - In one aspect of the invention, systems, methods, and devices are provided for handling liquid. In some embodiments, such systems, methods, and devices are used to process reagent biochemical reactions. | 2013-07-25 |
20130190214 | BIOCIDAL SYSTEM AND METHODS OF USE - Methods of treating a gas field fluid or oil field fluid is provided, the method comprising: a) adding glutaraldehyde to the gas field fluid or oil field fluid in an amount effective to reduce or inhibit microbial activity; and b) after a delay, adding 3,5-dimethyl-1,3,5-thiadiazinane-2-thione to the gas field fluid or oil field fluid. | 2013-07-25 |
20130190215 | Breaking Viscoelastic Surfactant Gelled Fluids Using Breadker Nanoparticles - Breaker nanoparticles may be added to gelled aqueous fluids where the gelled aqueous fluid may include an aqueous base fluid, e.g. a drilling fluid, gelled with at least one viscoelastic surfactant (VES) in an amount to increase the viscosity of the aqueous base fluid. The addition of the breaker nanoparticles may reduce the viscosity, or break the gel, of the gelled aqueous fluid by the direct or indirect action of the breaker nanoparticles. The breaker nanoparticles may be or include, but are not limited to inorganic semiconductor particles, organic semiconductor particles, and combinations thereof. The inorganic semiconductor particles may be or include, but are not limited to cupric oxide, cuprous oxide, silicon, silicon carbide, germanium, and gallium arsenide, indium antimonide, gallium nitride, and combinations thereof; wherein the organic semiconductors selected from the group consisting of pentacene, anthracene, rubrene, poly(3-hexylthiophene), poly(p-phenylene vinylene), polypyrrole, polyaniline, and combinations. | 2013-07-25 |
20130190216 | LOW FRICTION LUBRICATION ASSEMBLY - [Object] A low friction assembly is desired. | 2013-07-25 |
20130190217 | ESTER OILS - According to a first aspect, an ester oil, in particular for producing a hydraulic fluid and/or a lubricant, containing an esterification product from the esterification of at least one monoalcohol with at least one polycarboxylic acid, is characterized in that the monoalcohol and/or the polycarboxylic acid originates from renewable raw materials. According to a second aspect, an ester oil, in particular for producing a hydraulic fluid and/or a lubricant, containing an esterification product from the esterificati-on of at least one monocarboxylic acid with at least one dialcohol, is characterized in that the dialcohol and/or the monocarboxylic acid originates from renewable raw materials. | 2013-07-25 |
20130190218 | 4,4-DIMETHYL-DECAL-1-ONE OR -1-OL DERIVATIVES AS PERFUMING INGREDIENTS - The present invention relates to use of a compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein the dotted lines represent a single or double bond, and at least one of said dotted lines represents a double bond; n represents simultaneously 0, in which case the oxygen atom is bounded to the cyclanic carbon atom by a double bond, or 1, in which case the oxygen atom is bounded to the cyclanic carbon atom by a single bond, each R represents a hydrogen atom or a methyl group; R | 2013-07-25 |
20130190219 | METALLOCARBENE COMPLEX PEROXIDE ACTIVATORS - A bleaching composition comprising a peroxy compound and one or more activator present in an effective amount to activate the peroxy compound, present in an amount effective to accomplish bleaching or cleaning or oxidation. The activator is a metallocarbene of the general structure (XX′C) | 2013-07-25 |
20130190220 | Solid Soap - The object of the present invention is to improve the solidification point and the hardness of a soap of the fatty acid soap series wherein the percentage of potassium used as the counter ion is large. The solid soap of the present invention to achieve the above-described object is characterized by comprising 1 to 5 mass % of a betaine, and in that sodium and potassium are contained as the fatty acid counter ion, and potassium is 20 mole % or more of the counter ion. | 2013-07-25 |
20130190221 | MONOMERIC RECOMBINANT MHC MOLECULES USEFUL FOR MANIPULATION OF ANTIGEN-SPECIFIC T-CELLS - The present invention provides, in particular embodiments, for modified recombinant T cell receptor (TCR) ligands (RTLs) comprising a MHC class I or MHC class II component. The modified RTLs have redesigned surface features that preclude or reduce aggregation, wherein the modified molecules retain the ability to bind Ag-peptides, target antigen-specific T cells, inhibit T cell proliferation in an Ag-specific manner and have utility to treat, inter alia, autoimmune disease and other conditions mediated by antigen-specific T cells in vivo. | 2013-07-25 |
20130190222 | CONCENTRATED AQUEOUS SILK FIBROIN SOLUTION AND USE THEREOF - The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels. | 2013-07-25 |
20130190223 | NONIMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGUE MOLECULES - The compounds of the present invention are non-immunosupressive cyclosporine analogue molecules that are able to bind cyclophilin. Said compounds include a modified side chain of amino acid I of cyclosporin A, consisting of an oxyalkyl having substituents R′, R1 and R2, where R′ is H or Acetyl; R1 is a saturated or unsaturated straight chain or branched aliphatic carbon chain; and R2 may be a hydrogen; a unsubstituted, N substituted or NN disubstituted amide; a N substituted or unsubstituted acyl protected amine; a carboxylic acid; a N substituted or unsubstituted amine; a nitrile; a ester; a ketone; a hydroxy, dihydroxy, trihydroxy or polyhydroxy alkyl; or a substituted or unsubstituted aryl. | 2013-07-25 |
20130190224 | TREATMENT OF FIBROSIS-RELATED DISORDERS USING FIBRONECTIN BINDING PROTEINS AND POLYPEPTIDES - The present invention is directed to various uses of fibronectin binding proteins or polypeptides for treating and preventing fibrosis and fibrosis related conditions. The fibronectin binding proteins and polypeptides are also useful for treating conditions associated with vascular remodeling and cardiac dysfunction. | 2013-07-25 |
20130190225 | Use of Leptin for Treating Human Lipoatrophy and Method of Determining Predisposition to Said Treatment - Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including subcutaneously and using gene therapy methods. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having a leptin level of approximately 4 ng/ml or less before treatment. | 2013-07-25 |
20130190226 | RECONSTITUTED HIGH DENSITY LIPOPROTEIN FORMULATION AND PRODUCTION METHOD THEREOF - A reconstituted high density lipoprotein formulation having relatively low toxicity comprises an apolipoprotein such as ApoAI or fragment thereof, a lipid and a detergent at a level which is about 5-50% of that which would normally cause liver toxicity upon administration to a human. The lipid is optimally phosphatidylcholine at about 30-50 g/L and the molar ratio of apolipoprotein:lipid is optimally in the range 1:40 to 1:75. The formulation is useful for treating diseases or conditions such as cardiovascular disease, hypercholesterolaemia and hypocholesterolaemia inclusive of acute coronary syndrome (ACS), atherosclerosis and myocardial infarction. | 2013-07-25 |
20130190227 | CHITOSAN DERIVATIVES TO TREAT ANIMALS OR OPTIMIZE ANIMAL HEALTH - Described herein are methods of inhibiting the growth of or killing a bacterium in an animal subject, preventing or delaying onset of an infection with a bacterium in an animal subject, preventing or delaying onset of a pathogen mediated disease or disorder in an animal subject, or reducing bacterial load in an animal subject, comprising administering an effective amount of a derivatized chitosan to the animal. Also described herein are preparations comprising a chitosan derivative for administration to an animal. | 2013-07-25 |
20130190228 | NOVEL ANTIVIRAL PEPTIDES AGAINST INFLUENZA VIRUS - The present disclosure generally relates to peptides having antiviral properties. More particularly, the invention relates to peptides exhibiting activity against influenza viruses, to pharmaceutical compositions comprising the peptides, and to methods of using the peptides to prevent and/or treat influenza viral infections. | 2013-07-25 |
20130190229 | VITAMIN E FORMULATIONS OF SULFAMIDE NS3 INHIBITORS - The invention relates to new formulations of compounds having activity against HCV-associated disorders, new combinations, new methods of treatment and their use in therapy. | 2013-07-25 |
20130190230 | COMPOSITIONS AND METHODS FOR TREATING COGNITIVE DEFICITS - A method of treating or preventing cognitive impairment deficits in subjects with age-associated cognitive decline or a dementing illness includes administering to the subject a therapeutically effective amount of amylin, an amylin agonist, or an amylin derivative to treat the cognitive impairment or deficit. | 2013-07-25 |
20130190231 | PEPTIDE FOR SUPPRESSING AND TREATING OBESITY - The present invention relates to a composition for preventing, alleviating or treating obesity comprising a partial fragment of HIV-1 (Human Immunodeficiency Virus-1) Tat (Trans activator of transcription) protein. The peptides of the present invention induce anorexia and increase lipolysis, β-oxidation of free fatty acids, thermogenesis, and total energy expenditure, therefore may be effectively used for preventing or treating diseases related to metabolic imbalance such as obesity. | 2013-07-25 |
20130190232 | N-TERMINAL MODIFIED FGF21 COMPOUNDS - Analogues of FGF21 carrying a modifying, substituted ethylene or benzyl group can be used for treatment or prevention of diabetes, dyslipidemia, obesity, cardiovascular diseases, metabolic syndrome, and/or Non Alcoholic Fatty Liver Disease (NAFLD). | 2013-07-25 |
20130190233 | PEPTIDES, DERIVATIVES AND ANALOGS THEREOF, AND METHODS OF USING SAME - Human proIslet Peptides (HIP) and HIP analogs and derivatives thereof, derived from or homologous in sequence to the human REG3A protein, chromosome 2p12, are able to induce islet neogenesis from endogenous pancreatic progenitor cells. Human proIslet Peptides are used either alone or in combination with other pharmaceuticals in the treatment of type 1 and type 2 diabetes and other pathologies related to aberrant glucose, carbohydrate, and/or lipid metabolism, insulin resistance, overweight, obesity, polycystic ovarian syndrome, eating disorders and the metabolic syndrome. | 2013-07-25 |
20130190234 | THE USE OF ALKYLATED SEMI-SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS FOR THE TREATMENT OF DENTAL DISORDERS - Described herein are methods for treating a dental disorder in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C | 2013-07-25 |
20130190235 | FUSION PROTEIN FOR ANTAGONIZING ANGIOGENESIS INDUCIBLE FACTORS AND USES THEREOF - The present invention relates to angiogenesis-inhibitory fusion proteins and use thereof. Particularly, the present invention provides fusion proteins inhibiting a plurality of angiogenic factors. More particularly, the present invention relates to the fusion proteins of VEGF receptor and FGF receptor and their applications in the treatment of angiogenesis related diseases. | 2013-07-25 |
20130190236 | BMP-7 Variants with Reduced Immunogenicity - The invention is directed to bone morphogenetic proteins that have reduced immunogenicity. In particular, the invention is directed to human BMP-7 that has been modified to reduce immunogenicity through alteration of the amino acid sequence of wild-type BMP-7. | 2013-07-25 |
20130190237 | METHODS FOR CATEGORISING CANCER SUCH AS BREAST CANCER - A method for aiding in categorising or determining prognosis in a patient with cancer, for example breast cancer (or, for example, hepatocellular, bladder or gastric cancer) or in selecting a therapeutic strategy for a patient with cancer, for example breast cancer (or, for example, hepatocellular, bladder or gastric cancer), the method comprising the step of assessing the level of LMTK3 nucleic acid, protein or activity in a sample obtained from the patient and/or assessing the patient's genotype for LMTK3, optionally at position rs8108419 (in intron 2 of the LMTK3 gene) and/or position rs9989661 (in intron 15 of the LMTK3 gene). The method may further comprise the step of assessing the level of ERa nucleic acid, protein or activity in a sample obtained from the patient, particularly in the case of breast cancer. If the level of LMTK3 nucleic acid, protein or activity in the sample is an elevated level and/or the genotype is LMTK3 rs8108419AA or LMTK3 rs9989661 CT or CC then the selected treatment regime may be an aggressive treatment regime or may comprise treating the patient with an inhibitor of LMTK3 activity and/or an inhibitor of Fox03a activity. If the level of LMTK3 nucleic acid, protein or activity in the sample is not elevated and/or the genotype is LMTK3 rs8108419GA or GG or LMTK3 rs9989661 TT then the selected treatment regime may be a less aggressive treatment regime. | 2013-07-25 |
20130190238 | Treatments for Gastrointestinal Disorders - The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor. | 2013-07-25 |
20130190239 | Formulations Comprising Linaclotide - The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions. | 2013-07-25 |
20130190240 | TUMOR GROWTH CONTROLLING METHOD TARGETING GALACTOSYLCERAMIDE EXPRESSION FACTOR-1 - The object of the present invention is to provide an anti-tumor agent having an anti-angiogenic effect and/or an anti-tumor growth effect or a method for tumor growth inhibition. | 2013-07-25 |