29th week of 2022 patent applcation highlights part 22 |
Patent application number | Title | Published |
20220227665 | A Method and Apparatus for Processing Water Treatment Residuals - A method for processing water treatment residuals, or other amorphous aluminium oxide or aluminium hydroxide rich waste residuals, for use in the manufacture of hydraulic binders, comprising heating the residuals to remove water and oxidise organic material contained therein, comprising controlling the temperature of the residuals during heating such that they are heated to a temperature no higher than 800° C., more preferably no higher than 650° C., to ensure that aluminium compounds in the WTR, in particular aluminium oxide and aluminium hydroxide, remain in an amorphous state. The method may comprise controlling the temperature of the water treatment residuals such that they are heated to a temperature between 350° C. and 650° C., more preferably between 400° C. and 500° C. | 2022-07-21 |
20220227666 | A Method for the Manufacture of Hydraulic Binders from Water Treatment Residuals - A method for the manufacture of a high alumina hydraulic binder comprising hydrating a source of aluminium ions with a source of calcium ions in the presence of water to form mineral hydrates and subsequently heating said mineral hydrates to form said high alumina hydraulic binder. | 2022-07-21 |
20220227667 | Method for Preparing a Coated Particulate Waste Material and a Coated Waste Particle - The current invention concerns a method for preparing a coated particulate waste material, comprising the steps of: (a) providing a particulate waste material with an average particle size of between 0.1 and 5.0 mm, and (b) applying a coating material to said particulate waste material, whereby said coating material comprises at least one polymeric compound. | 2022-07-21 |
20220227668 | PREPARATION METHOD FOR ADMIXTURE FOR PLASTERBOARD, ADMIXTURE PREPARED THEREBY, AND COMPOSITION FOR FORMING PLASTERBOARD COMPRISING SAME - A method of preparing an admixture for a plasterboard is disclosed. An admixture prepared by the method and a composition for forming a plasterboard containing the admixture are also disclosed. The method includes sulfonation of polystyrene using sulfuric acid to give an admixture including a sulfonated polystyrene (SPS)-based compound of formula 1 below. The admixture enables regulation of properties of a plasterboard, such as foam size, flowability, and setting time, by regulating a degree of sulfonation (DS) of the SPS-based compound: | 2022-07-21 |
20220227669 | SLAG-CONTAINING POLYMER CONCRETE AND GROUTING MORTAR - A curable binder composition includes: a) at least one organic binder selected from the group made of a1) epoxy resins and curing agents for epoxy resins and a2) polyisocyanates and polyols, and b) at least 50% by weight of slag based on 100% by weight of the binder composition. | 2022-07-21 |
20220227670 | METHOD FOR MANUFACTURING CERAMIC ARTICLE, METAL COMPONENT-CONTAINING LIQUID, KIT FOR MANUFACTURING CERAMIC ARTICLE, AND CERAMIC ARTICLE - A method for manufacturing a ceramic article including (i) a step of irradiating a powder mainly containing a ceramic material with an energy beam to sinter or melt and solidify the powder into a solidified portion, wherein the step is repeated a predetermined number of times to sequentially bond the resulting solidified portions together to obtain a ceramic modeling object, (ii) a step of allowing the shaped ceramic object to absorb a metal component-containing liquid that contains inorganic particles containing a metal element; and (iii) a step of heating the shaped ceramic object that has absorbed the metal component-containing liquid. | 2022-07-21 |
20220227671 | METHOD FOR PREPARATION OF POROUS MULLITE CERAMIC FROM PICKERING EMULSION - An improved method for preparing porous mullite ceramic from Pickering emulsions stabilised by hetero-aggregate of oppositely charged fumed oxide particles. The method uses oppositely charged fumed oxide nano-particles (silica and alumina) to stabilize oil-in-water Pickering emulsions wherein the stabilized Pickering emulsions can be used as a template for preparing porous mullite material. An optimised Pickering emulsion template that is stabilised with fumed oxide nano-particles (silica and alumina) is used to produce a green body that is transformed into solid porous material with a controlled porosity and pore size by sintering. | 2022-07-21 |
20220227672 | CERAMIC BODY AND METHOD FOR PRODUCING SAME, HEATER ELEMENT, HEATER UNIT, HEATER SYSTEM AS WELL AS PURIFICATION SYSTEM - A ceramic body being configured of mainly BaTiO | 2022-07-21 |
20220227673 | DIELECTRIC COMPOSITION AND ELECTRONIC COMPONENT - In order to provide a dielectric composition having high density even when fired at a relatively low temperature, the main component of a dielectric composition includes tantalum and at least one of barium or strontium, and the subcomponent of the dielectric composition includes at least one element selected from the group consisting of vanadium, titanium, and aluminum. | 2022-07-21 |
20220227674 | CERAMIC MATRIX COMPOSITE AND METHOD FOR MANUFACTURING SAME - A ceramic matrix composite includes a substrate which contains a fibrous body formed from a silicon carbide fiber, and a matrix which is formed in the substrate, and which contains RE | 2022-07-21 |
20220227675 | HIGH STRENGTH CERAMICS WITH NOVEL FRACTURE MODE - The present invention provides a method for making a high strength, small grain size ceramic having a transgranular fracture mode by rapid densification of a green body and subsequent cooling of the densified ceramic. The ceramic may include dislocations, defects, dopants, and/or secondary phases that are formed as a result of the process and resulting in stress fields capable of redirecting or arresting cracks within the material. This ceramic can maintain transparency from ultraviolet to mid-wave infrared. | 2022-07-21 |
20220227676 | SILICON CARBIDE BODY WITH LOCALIZED DIAMOND REINFORCEMENT - A reaction-bonded silicon carbide (SiC) body is produced by: providing a preform including ceramic elements and carbon, and one or more surface features; providing a powder which includes diamond particles and carbon; locating the powder in the surface feature(s); and infiltrating the preform and the powder with molten silicon (Si) to form reaction-bonded SiC in the preform, and to form reaction-bonded SiC coatings on the diamond particles. The present disclosure also relates to a device/component which includes: a main body portion and discrete elements located at least partially within the main body portion. The main body portion may include reaction-bonded SiC and Si, but not diamond, while the discrete elements include diamond particles, reaction-bonded SiC coatings surrounding the diamond particles, and Si. According to the present disclosure, diamond may be advantageously located only where it is needed. | 2022-07-21 |
20220227677 | CARBONATION SYSTEM FOR CURING OF CONCRETE PRODUCTS AT AMBIENT PRESSURE - Provided herein are systems for carbonation curing and CO | 2022-07-21 |
20220227678 | Artificial Marble - Provided is artificial marble including an artificial marble substrate having a first surface having an arithmetic mean roughness (Ra) of 1 μm to 12 μm; and a photocatalyst layer directly on the first surface. The artificial marble according to the present invention is lighter than existing natural stone and exhibits excellent thermoformability, and also has excellent antifouling properties by means of a photocatalyst, and thus can be widely used in various fields requiring artificial marble. | 2022-07-21 |
20220227679 | COMPOSITION FOR COATING SUBSTRATES - The present invention provides an aqueous dispersion comprising (a) an active agent which is a humic substance and (b) fumed silica, wherein: the % by weight of the active agent with respect to the total weight of the dispersion is comprised from 1 to 50%; and the weight ratio between the active agent and the fumed silica is comprised from 1.5:1 to 75:1, particularly from 1.5:1 to 60:1. | 2022-07-21 |
20220227680 | BUFFERED COCO MATERIAL - A method of buffering coco material includes cleaning a quantity of untreated coco material to result in cleaned coco material, applying buffered water to the cleaned coco material to produce treated coco material, aging the treated coco material to produce aged coco material, and cleaning the aged material to produce buffered coco material. | 2022-07-21 |
20220227681 | BIOSOLID STORAGE AND DISPERSAL - A particle is provided that includes 5 wt % to 90 wt % of agricultural biomass, combustion residues, biosolids, or a combination thereof. A binder intermixed with the agricultural biomass, combustion residues, biosolids, or a combination thereof retains the mixture in the form of a particle. The resultant particle creates a use for existing waste streams while also improving soil quality. A process of stabilizing agricultural biomass, combustion residues, biosolids, or a combination thereof particles is also provided that includes combining agricultural biomass, combustion residues, biosolids, or a combination thereof with mineral and/or synthetic chemical fragments having a bulk density of greater than about 40 pounds per cubic foot and a sizing of about 100% passing through a 30 mesh screen and about 50% or more passing through a 200 mesh screen. By adding binder, a particle is formed that is deodorized and/or stabilized. | 2022-07-21 |
20220227682 | PELLETS CONTAINING AGRICULTURAL TREATMENT MATERIALS AND METHODS OF MAKING SAME - Pellets for use in agricultural applications are disclosed herein. The pellets can include a porous substrate having an internal interconnected porosity. An agricultural treatment material can be disposed into at least a portion of the internal interconnected porosity of the porous substrate. | 2022-07-21 |
20220227683 | CO2 UTILIZATION IN MOLTEN SALT REACTOR (MSR) FOR ULTRA ENERGY EFFICIENCY AND REDUCED EMISSIONS - A system for a carbon neutral cycle of gas production may include a molten salt reactor configured to generate zero carbon dioxide (CO | 2022-07-21 |
20220227684 | PRODUCTION APPARATUS AND PRODUCTION METHOD OF TRIPTANE - Production apparatus of triptane includes: carbon dioxide recovery unit configured to recover carbon dioxide from air; hydrogen generation unit configured to electrolyze water by renewable electricity to generate hydrogen; carbon monoxide generation unit configured to generate carbon monoxide from recovered carbon dioxide and hydrogen generated; methanol generation unit configured to generate methanol from carbon monoxide generated and hydrogen generated; acetic acid generation unit configured to generate acetic acid by reacting methanol generated with recovered carbon dioxide or with carbon monoxide generated; acetone generation unit configured to generate acetone and carbon dioxide from acetic acid generated; pinacolone generation unit configured to generate pinacolone from acetone generated; Grignard reagent generation unit configured to generate Grignard reagent from methanol generated; trimethyl butanol generation unit configured to generate 2,3,3-trimethyl-2-butanol by reacting pinacolone generated with Grignard reagent generated; and triptane generation unit configured to generate 2,2,3-trimethylbutane from 2,3,3-trimethyl-2-butanol generated. | 2022-07-21 |
20220227685 | SIMULTANEOUS DEHYDRATION, DIMERIZATION, AND METATHESIS OF C2-C5 ALCOHOLS - This disclosure relates to a single stage process for the direct conversion of alcohols, e.g. ethanol, to olefinic mixtures (C | 2022-07-21 |
20220227686 | ISOBUTYL BENZENE AND A PROCESS FOR SYNTHESIS OF ISOBUTYL BENZENE BY USING A CATALYST - The present disclosure provides a process for the synthesis of isobutyl benzene by side chain alkylation of toluene in the presence of a catalyst. The catalyst used in the process of present disclosure provides maximum conversion of toluene with high selectivity towards isobutyl benzene. | 2022-07-21 |
20220227687 | METHODS FOR OPERATING ACETYLENE HYDROGENATION UNITS IN INTEGRATED STEAM CRACKING AND FLUIDIZED CATALYTIC DEHYDROGENATION SYSTEMS - A method for operating an acetylene hydrogenation unit in an integrated steam cracking-fluidized catalytic dehydrogenation (FCDh) system may include separating a cracked gas from a steam cracking system and an FCDh effluent from an FCDh system into a hydrogenation feed and an acetylene-depleted stream, the hydrogenation feed comprising at least hydrogen, CO, and acetylene. During normal operating conditions, at least 20% of the CO in the hydrogenation feed is from the cracked gas. The method may include contacting the hydrogenation feed with an acetylene hydrogenation catalyst to hydrogenate at least a portion of the acetylene in the hydrogenation feed to produce a hydrogenated effluent. The steam cracking is operated under conditions that increase CO production such that a concentration of CO in the cracked gas is great enough that when a flowrate of the FCDh effluent is zero, a CO concentration in the hydrogenation feed is at least 100 ppmv. | 2022-07-21 |
20220227688 | HEXANE AS A BY-PRODUCT OF ISOMERIZATION UNIT USING A DIVIDING WALL COLUMN - A dividing wall column system for producing hexane includes a dividing wall column including a dividing wall that divides the dividing wall column at least partially into a first side and a second side, with one side of the first and second sides configured to operate as a deisohexanizer column and the other side of the first and second side configured to operate as a hexane column to produce hexane. | 2022-07-21 |
20220227689 | METHOD AND PLANT FOR PREPARING VINYL CHLORIDE FROM 1,2-DICHLOROETHANE - The present invention relates to a method for preparing vinyl chloride by catalytic thermal cracking of 1,2-dichloroethane, in which method the heat required for the thermal cracking is supplied via a liquid or condensing heat transfer medium. The present invention also relates to a plant for preparing vinyl chloride by catalytic thermal cracking of 1,2-dichloroethane, in which the heat required for the thermal cracking, as well as for the preceding preheating, evaporation and optionally overheating of the 1,2-dichloroethane, is supplied via a liquid or condensing heat transfer medium, said plant comprising at least one reactor in which the thermal cracking takes place and at least one first heating device by means of which heat is transported to the reaction medium in the reactor by means of the liquid or condensing heat transfer medium. | 2022-07-21 |
20220227690 | METHOD AND PLANT FOR PREPARING VINYL CHLORIDE FROM 1,2-DICHLOROETHANE - Disclosed is a method for preparing vinyl chloride by catalytic thermal cracking of 1,2-dichloroethane, in which method the heat required for the thermal cracking is supplied via a liquid or condensing heat transfer medium, wherein, the heat transfer medium is heated at least in part by means of waste heat from a plant for combusting liquid and/or gaseous residues of a chemical plant. The invention also relates to a plant for preparing vinyl chloride by catalytic thermal cracking of 1,2-dichloroethane. The heat required for thermal cracking can be obtained from cheaply available waste heat. For example, it is possible to temporarily heat the heat transfer medium exclusively by means of the second heating device operated by waste heat, wherein said waste heat can, for example, be waste heat from a plant for preparing vinyl chloride. | 2022-07-21 |
20220227691 | METHOD FOR PRODUCING ALCOHOL - A method for producing an alcohol by hydrating an olefin using a heteropolyacid catalyst is provided, in which an alcohol having high product purity can be stably produced over a long period of time. The method is for producing an alcohol by supplying a raw material mixture comprising water and an olefin having a carbon atom number of X, wherein X is an integer of 2 to 5, to a reactor and subjecting them to a hydration reaction in a gas phase using a solid acid catalyst on which a heteropolyacid or a salt thereof is supported to obtain a reaction product, wherein the content of an impurity olefin having a carbon atom number of Y, wherein Y is an integer of 2 to 6 and Y and X are different, contained in the raw material mixture is 700 mol ppm or less. | 2022-07-21 |
20220227692 | COMPOSITIONS AND METHODS OF MAKING RIBITOL - The present disclosure describes compositions comprising substantially pure ribitol, pharmaceutical compositions of ribitol, and methods of making ribitol. The methods may include combining a reducing agent (e.g., borohydride) and ribose (e.g. D-ribose), optionally with stirring, to form a first reaction mixture; and contacting the first reaction mixture and an acidic quenching agent, optionally with stirring, to form a second reaction mixture, thereby forming ribitol. | 2022-07-21 |
20220227693 | VINYL-ETHERS AND METHODS OF THEIR PRODUCTION - The present invention relates to methods for producing at least one vinyl ether compound of formula (1) and to a vinyl ether compound of formula (1) preferably obtainable by the methods according to the invention. Furthermore, the present invention relates to a polymer obtainable by polymerizing the vinyl ether compound of formula (1) according to the invention, to an adhesive comprising the at least one polymer according to the invention and to the use of at least one vinyl ether compound of formula (I) according to the invention or at least one polymer according to the invention for the production of UV adhesives, cationic curings or 1-component or 2-component systems. | 2022-07-21 |
20220227694 | Method of Depolymerising Phenolic Polymers - The invention provides a method for depolymerising a phenolic polymer, the method comprising reacting the phenolic polymer with dimethylsulphoxide (DMSO) and a hydrogen halide. The phenolic polymer may be selected from the group consisting of lignin and derivatives thereof. The hydrogen halide may be HBr. The quantity of hydrogen halide per gram of phenolic polymer may be from 30 mmoles to 70 mmoles. The quantity of DMSO per gram of phenolic polymer may be from 0.1 mole to 1 mole. The reaction may be performed at a temperature of from 100 to 120° C. The reaction may be carried out for between 10 h and 14 h. The product of the reaction may comprise vanillin. | 2022-07-21 |
20220227695 | Method Of Producing A Low Glycidol Monoglyceride Composition And The Low Glycidol Monoglyceride Composition As Such - The present invention pertains to a method of producing monoglyceride compositions having a low glycidol content. The invention furthermore pertains to such monoglyceride compositions which can be obtained by the method. | 2022-07-21 |
20220227696 | Multifunctional Fluorinated Compound, Fluorinated Polymers Made from the Compound, and Related Methods - The multifunctional compound is represented by formula X—C(R)RF—Y, in which X and Y are each independently —C(O)—O-M, —C(O)-HAL, —C(O)—NR | 2022-07-21 |
20220227697 | METHOD FOR PRODUCING HIGHLY POLYMERIZABLE N-VINYL CARBOXYLIC ACID AMIDE MONOMER - A method for producing a highly polymerizable N-vinyl carboxylic acid amide monomer includes (A) melting a crude N-vinyl carboxylic acid amide monomer comprising 50 to 88 mass% of an N-vinyl carboxylic acid amide monomer by heating, followed by cooling for precipitation, and subjecting precipitated N-vinyl carboxylic acid amide monomer crystals to solid-liquid separation (step (A)), and (B) further dissolving the N-vinyl carboxylic acid amide monomer crystals separated in step (A) in a mixed solvent of acetonitrile and an aliphatic hydrocarbon having 6 to 7 carbon atoms, then performing crystallization, performing solid-liquid separation, and recovering an N-vinyl carboxylic acid amide monomer purified product (step (B)), wherein a mass ratio of acetonitrile/N-vinyl carboxylic acid amide monomer crystal in step (B) is 0.01 to 0.5, and a mass ratio of aliphatic hydrocarbon having 6 to 7 carbon atoms/N-vinyl carboxylic acid amide monomer crystal in step (B) is 0.5 to 3.0. | 2022-07-21 |
20220227698 | NOVEL THYROMIMETICS WITH A BIPHENYLMETHANE SCAFFOLD AND THEIR USE - The invention concerns a compound of Formula (I) or a salt thereof, wherein R | 2022-07-21 |
20220227699 | AROMATIC RING OR HETEROAROMATIC RING DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF - The present invention relates to aromatic ring or heteroaromatic ring derivatives, a preparation method therefor and applications thereof in medicine. Specifically, the present invention relates to aromatic ring or heteroaromatic ring derivatives represented by general formula (I), a preparation method therefor and pharmaceutically acceptable salts thereof, as well as a use thereof as therapeutic agents, especially uses as angiotensin II type 2 receptor (AT | 2022-07-21 |
20220227700 | HDAC3 CATALYTIC INHIBITOR DEVELOPMENT AND USES THEREOF - Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC3 activity. | 2022-07-21 |
20220227701 | METHOD FOR THE RECYCLING OF POLYURETHANE MATERIAL WASTE FOR PRODUCING CHEMICAL FEEDSTOCK FOR THE PRODUCTION OF ISOCYANATES AND POLYURETHANES - The invention relates to a method for recycling polyurethane material waste ( | 2022-07-21 |
20220227702 | IMPROVED METHOD OF SYNTHESIS AND PURIFICATION OF CITRULLINE - This invention provides for synthesis of citrulline from a transition metal complex of ornithine using cyanate to derivatize the terminal amino group of ornithine. The invention also provides improved methods for purification of citrulline produced by reaction of cyanate with ornithine via the steps of reprecipitation of copper complex of citrulline, removal of the complexing metal by sulfide precipitation, activated carbon adsorption and antisolvent crystallization. | 2022-07-21 |
20220227703 | CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF - The present disclosure provides creatine prodrug analogs and their compositions useful for the treatment of creatine deficiencies. | 2022-07-21 |
20220227704 | NOVEL PROCESS FOR FILTERING 2-ACRYLAMIDO-2-METHYLPROPANE SULFONIC ACID - A continuous process for filtering a suspension of 2-acrylamido-2-methylpropane sulfonic acid crystals by means of a rotary pressure filter equipped with a drum, a surface of which is provided with cells covered with a filter medium, the drum rotating within a fixed concentric cylinder comprising at least three zones sealed from each other, respectively a filtration zone, a washing zone and a discharge zone, each zone opening onto the cells. | 2022-07-21 |
20220227705 | CATHEPSIN INHIBITORS - This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Cathepsin K (CatK), and to a method of inhibiting cathepsin activity, comprising administering a compound or formulation comprising a compound according to the invention. | 2022-07-21 |
20220227706 | PROCESS FOR THE PREPARATION OF METHIONINE - The present invention relates to a process for the preparation of methionine comprising the step of contacting a solution or suspension comprising 2-amino-4-(methylthio)butanenitrile and/or 2-amino-4-(methylthio)butaneamide with water in the presence of a catalyst to give a methionine comprising mixture, wherein the catalyst comprises CeO2 comprising particles, wherein the CeO2 comprising particles have a BET surface area of from 175 to 300+/−10% m2/g measured according to DIN ISO 9277-5 (2003), a mean maximum Feret diameter x | 2022-07-21 |
20220227707 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY - In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: Formula (AA) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein. | 2022-07-21 |
20220227708 | METHODS FOR FORMING PEROXYFORMIC ACID AND USES THEREOF - The present invention relates generally to methods for forming peroxyformic acid, comprising contacting formic acid with hydrogen peroxide. The methods for forming peroxyformic acid can include adding formic acid with a relatively lower concentration of hydrogen peroxide, or adding formic acid to a peroxycarboxylic acid composition or forming composition to react with hydrogen peroxide in the compositions. The present invention also relates to peroxyformic acid formed by the above methods. The present invention further relates to the uses of peroxyformic acid for treating a variety of targets, e.g., target water, including target water used in connection with oil- and gas-field operations. The present invention further relates to methods for reducing or removing H | 2022-07-21 |
20220227709 | COMPOSITIONS AND METHODS FOR TREATING SCHISTOSOMA INFECTIONS - Disclosed are composition and methods for treating | 2022-07-21 |
20220227710 | HETEROGENEOUS CATALYZED PROCESS FOR THE PRODUCTION OF 2,2,6,6-TETRAMETHYL-4-PIPERIDONE - The present invention relates to a process for the production of 2,2,6,6-tetramethyl-4-piperidone particularly comprising
| 2022-07-21 |
20220227711 | HYDROPHILIC HIGH QUANTUM YIELD ACRIDINIUM ESTERS WITH IMPROVED STABILITY AND FAST LIGHT EMISSION - Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus. | 2022-07-21 |
20220227712 | Cholinesterase inhibitor polymorph and application thereof - A cholinesterase inhibitor polymorph, wherein specifically disclosed are a octahydroaminoacridine succinate polymorph, a corresponding crystal composition and pharmaceutical composition, and applications thereof. The compound octahydroaminoacridine succinate is used for screening and studying polymorphs, and the discovered polymorphs are appraised and evaluated; crystal forms having better physical and chemical properties are determined for subsequent development and study, and crystal forms having good stability and an excellent therapeutic effect are obtained. | 2022-07-21 |
20220227713 | TETRAHYDRO-1H-BENZAZEPINE COMPOUND AS POTASSIUM CHANNEL MODULATOR, PREPARATION METHOD AND USE THEREOF - A tetrahydro-1H-benzazepine compound as a potassium channel modulator, a preparation method, and a medicament containing the compound are provided. Specifically, the compound has the structure shown by formula A, in which the definitions of each group and substituent are described in the description. A preparation method for the compound and its use as potassium channel modulator are also described. | 2022-07-21 |
20220227714 | A SCALABLE SYNTHESIS OF DUAL-TARGET INHIBITOR OF CANNABINOID-1 RECEPTOR AND INDUCIBLE NITRIC OXIDE SYNTHASE - A process for the preparation of racemic and optically active (1E,NE)-N-(1-aminoethylidene)-3-(4-chlorophenyl)-4-phenyl-N′-((4-(trifluoromethyl)phenyl)sulfonyl)-4,5-dihydro-1H-pyrazole-1-carboximidamide in high enantiomerical purity is provided. | 2022-07-21 |
20220227715 | SULFONYLUREA DERIVATIVES AND USES THEREOF - The present disclosure relates to compounds of Formula (I) | 2022-07-21 |
20220227716 | BENZIMIDAZOLE AND HYDROGENATED CARBAZOLE DERIVATIVES AS GPX4 INHIBITORS - This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent. | 2022-07-21 |
20220227717 | ALLOSTERIC ACTIVATORS OF THE ALPHA1A-ADRENERGIC RECEPTOR - The present invention relates to compounds that are activators of the Alpha | 2022-07-21 |
20220227718 | Hydroxy-Functionalized Triazine Compounds, Curable Fluoropolymer Compositions Comprising Such Compounds and Cured Articles Therefrom - Described herein are compounds according to Formula (I) wherein each Rf is independently selected from a perfluorinated divalent group comprising 2 to 12 carbon atoms; and m is an integer independently selected from 1 to 3. A method of making the compound from a hydroxy-containing vinyl ether and excess ammonia is disclosed. In one embodiment, the hydroxy-functionalized triazine compound is used in a curable fluoropolymer composition and cured to form articles. | 2022-07-21 |
20220227719 | A diphenylamine-linked chiral bis(oxazoline) ligand without C2-symmetry, synthesis method and application thereof - The present invention discloses a diphenylamine-linked chiral bis(oxazoline) ligand without C | 2022-07-21 |
20220227720 | DHODH INHIBITORS AND THEIR USE AS ANTIVIRAL AGENTS - The present invention relates to a compound, or a dimer or a pharmaceutically acceptable salt or solvate of said compound or dimer, for use in a method for the treatment of a disease, disorder or condition caused by an RNA virus, said compound having the general structure shown in Formula (I). | 2022-07-21 |
20220227721 | P-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF - p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical application thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener. | 2022-07-21 |
20220227722 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATOR - A compound is provided having following structure Compound (1): or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof. Also provided is a pharmaceutical composition comprising Compound (1) or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, in combination with a pharmaceutically acceptable carrier or diluent. | 2022-07-21 |
20220227723 | 2,3-DIARYL-1,3-THIAZEPAN-4-ONES COMPOUNDS AND METHODS FOR MAKING - A compound with the following general formula (I) and a general method for making this compound are provided, R | 2022-07-21 |
20220227724 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE UNCHARGED BISOXIME ANTIDOTES FOR ORGANOPHOSPHATE POISONING AND METHODS FOR MAKING AND USING THEM - In alternative embodiments, provided are uncharged bis-oxime antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase (hAChE) in the central nerve system (CNS). In alternative embodiments, provided are pumps, devices, subcutaneous infusion devices, continuous subcutaneous infusion devices, infusion pens, needles, reservoirs, ampoules, a vial, a syringe, a cartridge, a disposable pen or jet injector, a prefilled pen or a syringe or a cartridge, a cartridge or a disposable pen or jet injector, a two chambered or multi-chambered pump, a syringe, a cartridge or a pen or a jet injector, comprising a compound as provided herein. | 2022-07-21 |
20220227725 | PROCESS FOR THE PRODUCTION OF FURFURAL - A process for the production of furfural from a biphasic composition including furfural, an organic solvent and soluble organic debris. The said process includes subjecting the biphasic composition to a liquid-liquid separation step to provide an organic phase and an aqueous phase. The organic phase includes the organic solvent, a first portion of the furfural and a first portion of soluble organic debris. The aqueous phase includes a remainder portion of the furfural and a remainder portion of soluble organic debris. The organic phase is subjected to a distillation step to provide a furfural stream and an organic solvent stream including the organic solvent and the first portion of the soluble organic debris. The organic solvent stream is conveyed to an adsorption unit to adsorb a second portion of the soluble organic debris, forming an organic debris-depleted recycle stream. | 2022-07-21 |
20220227726 | CANNABINOID GLYCOSIDES AND USES THEREOF - The present invention provides tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs and pharmaceutical compositions comprising these compounds, and their use for the site specific delivery of tetrahydrocannabinol or cannabidiol. Also provided are processes for the preparation of purified tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs. | 2022-07-21 |
20220227727 | COMPOSITIONS AND METHODS FOR INHIBITING IDO1 - Provided herein are compounds that inhibit IDO1 and methods of use thereof. Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating sarcopenia or age-related muscle loss. | 2022-07-21 |
20220227728 | Microtubule-associated protein Tau imaging compounds for Alzheimer's disease and precursors thereof - The present invention discloses a series of nuclear medicine tracers that are combined with brain microtubule-associated protein Tau targeting compounds to produce a group of compounds of nuclear medicine that can be utilized for imaging of microtubule-associated protein Tau. When the positrons released by the decay encounter the electrons of the cells in the sample, utilizing the positron decay characteristics of fluorine-18 or iodine-124 isotope to generate mutual destruction reactions, a pair of opposite gamma rays is formed which are imaged by positron emission tomography. The compounds can be applied for the in vivo detection of microtubule-associated protein Tau deposits in the brain. The invention provides a strategy for diagnosis of Alzheimer's disease and a method to measure the efficacy of therapeutic drugs targeting microtubule-associated protein Tau. | 2022-07-21 |
20220227729 | IDENTIFICATION AND USE OF KRAS INHIBITORS - The present invention relates to compounds of formula (1) in which A, U and R | 2022-07-21 |
20220227730 | TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS - Provided herein are methods of using IRE1 small molecule inhibitors in combination therapies for treating fibrosis in a subject. The IRE1 small molecule inhibitors described herein may be used in combination therapies for treating fibrosis | 2022-07-21 |
20220227731 | PROTEASE INHIBITORS, PREPARATION, AND USES THEREOF - The disclosure provides at compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating a disease and/or a symptom of a disease caused by a coronavirus. | 2022-07-21 |
20220227732 | PYRIDINE CARBOXAMIDE COMPOUNDS FOR INHIBITING NAV1.8 - Pyridine carboxamide compounds for inhibiting NaV1.8 and methods for treating a condition, disease, or disorder associated with an increased NaV1.8 activity or expression are disclosed. | 2022-07-21 |
20220227733 | PD-L1 ANTAGONIST COMPOUND - Provided is a compound represented by formula (I) and a pharmaceutical composition thereof, as well as a method for using a compound represented by formula (I) to prevent and/or treat immune-related disorders. | 2022-07-21 |
20220227734 | DEGRADERS OF CYCLIN-DEPENDENT KINASE 12 (CDK12) AND USES THEREOF - Provided herein are bifunctional compounds with a moiety (e.g., lenalidomide, thalidomide) that is a binder of an E3 ubiquitin ligase (e.g., Cereblon) and another moiety that is a binder of a target protein (e.g., kinase (e.g., CDK (e.g., CDK9 and/or CDK12))) to induce degradation of the target protein CDK9 and/or CDK12. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers (e.g., ovarian cancer, breast cancer, or prostate cancer))). Provided also are methods of inducing the degradation of the target protein (e.g., kinase (e.g., CDK (e.g., CDK9 and/or CDK12))), and methods of inducing apoptosis in a cell in a biological sample or subject by administering the bifunctional compound or composition described herein. | 2022-07-21 |
20220227735 | THERAPEUTIC METHODS AND COMPOUNDS - The invention provides a compound of formula I: (I) or a pharmaceutically acceptable salt thereof, wherein R | 2022-07-21 |
20220227736 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS - The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases. | 2022-07-21 |
20220227737 | NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) - The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds. | 2022-07-21 |
20220227738 | KRAS G12C INHIBITORS AND USES THEREOF - The invention relates to compounds of Formula I, and pharmaceutically acceptable salts thereof, and methods of making and using the same. The compounds of the invention are effective in inhibiting KRAS protein with a G12C mutation and are suitable for use in methods of treating cancers mediated, in whole or in part, by KRAS G12C mutation. | 2022-07-21 |
20220227739 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR - The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity. | 2022-07-21 |
20220227740 | Modulators of RAS GTPase - RAS modulating compounds and methods of using the same are provided. The compounds find use in modulating the activity of a target RAS in a sample. The target RAS can be a mutant RAS that is implicated in a disease of interest. In some cases, the subject compounds can inhibit the growth of cancer cells whose progression is driven by kRAS or a mutated kRAS. Methods of treating a subject for a RAS driven disease including administering a therapeutically effective amount of the subject compound are provided. Also provided are pharmaceutical compositions and kits which include the subject compounds. | 2022-07-21 |
20220227741 | NEW THERAPEUTIC VECTORS AND PRODRUGS FOR TREATING CANCERS - The present invention relates to a compound having the following formula (I): | 2022-07-21 |
20220227742 | ANTICANCER AND ANTIFUNGAL SPLICE MODULATORS - Provided herein, inter alia, are splice modulator compounds. The compounds include optically pure, stereospecific analogs of FD-895. The methods provided herein allow, for example, for scalable preparation of said compounds, and further allow, for example, use of said compounds for inhibiting spliceosome activity. | 2022-07-21 |
20220227743 | PRODRUG OF CASPASE INHIBITOR - The present invention relates to: an isooxazoline derivative having an ester moiety, the isoxazoline derivative being a prodrug of a caspase inhibitor, and a pharmaceutical composition containing same. | 2022-07-21 |
20220227744 | HERBICIDAL COMPOUNDS - Compounds of the formula (I) wherein the substituents are as defined in claim | 2022-07-21 |
20220227745 | Compounds For Modulating FXR - Provided herein are compounds of Formula (I), a stereoisomer, enantiomer or a pharmaceutically acceptable salt thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR). | 2022-07-21 |
20220227746 | BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS - The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 2022-07-21 |
20220227747 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY - The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R | 2022-07-21 |
20220227748 | NOVEL PROCESS FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS - The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula (I), including Compound (I), in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds. | 2022-07-21 |
20220227749 | AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS - The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X | 2022-07-21 |
20220227750 | METHODS AND COMPOSITIONS FOR PREVENTION OF ANAPHYLAXIS - Embodiments of the invention include methods of preventing and/or reducing the risk or severity of an allergic reaction in an individual. In some embodiments, particular small molecules are employed for prevention and/or reduction in the risk or severity of anaphylaxis. In at least particular cases, the small molecules are inhibitors of STAT3. In some cases, the small molecule comprises N-(1′,2-dihydroxy-1,2′-binaphthalen-4′-yl)-4-methoxybenzenesulfonamide. | 2022-07-21 |
20220227751 | NOVEL DIHYDROPYRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS. - A compound according to Formula Ia: | 2022-07-21 |
20220227752 | PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF - Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. | 2022-07-21 |
20220227753 | METHODS OF PREPARING HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS - The present invention provides methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators, and compositions having low impurity levels. | 2022-07-21 |
20220227754 | AMPK ACTIVATORS - This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists or partial agonists. | 2022-07-21 |
20220227755 | SUBSTITUTED PYRROLOPYRIDINES AS ATR INHIBITORS - The disclosure includes compounds of Formula (I) wherein A, W, m, R | 2022-07-21 |
20220227756 | SUBSTITUTED IMIDAZOQUINOLINES - The invention relates to imidazoquinoline derivatives and to pharmaceutical compositions containing the imidazoquinoline derivatives. The imidazoquinoline derivatives of the invention are useful as toll-like receptor agonists, in particular agonists of TLR7, and promote induction of certain cytokines. | 2022-07-21 |
20220227757 | QUINAZOLINE-2,4-DIONE DERIVATIVES AS PARP INHIBITORS - The present invention relates to compounds and compositions containing said compounds acting as PARP inhibitors (Poly (ADP-ribose) polymerase). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the treatment of cell proliferative disorders, such as cancer. | 2022-07-21 |
20220227758 | IMIDAZOPYRIDINE COMPOUND AS IRAK4 INHIBITOR - A class of IRAK4 inhibitors are used in the preparation of drugs for the treatment of diseases related to IRAK4. A compound as represented by formula (II), an isomer thereof or a pharmaceutically acceptable salt thereof is an example of the IRAK4 inhibitors. | 2022-07-21 |
20220227759 | AMORPHOUS PI3K INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME - The present invention relates to an amorphous PI3K inhibitor and a pharmaceutical composition comprising same. According to the present invention, a novel amorphous PI3K inhibitor having improved solubility and bioavailability and excellent stability and a pharmaceutical composition comprising same can be provided. | 2022-07-21 |
20220227760 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY - This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same. | 2022-07-21 |
20220227761 | OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE - Compounds of Formulae I, II, their pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formulae I or II as effective modulators of STING are also provided. | 2022-07-21 |
20220227762 | AMIDE-SUBSTITUTED IMIDAZO COMPOUNDS AS SELECTIVE INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASES - Disclosed herein are amide-substituted imidazo compounds and pharmaceutical compositions comprising at least one such novel benzoimidazoles, processes for the preparation thereof, and the method for using the same in therapy. In particular, disclosed herein are certain amide-substituted imidazo compounds that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby. | 2022-07-21 |
20220227763 | MICROBIOCIDAL DERIVATIVES - Compounds of the formula (I) wherein the substituents are as defined in claim | 2022-07-21 |
20220227764 | Imidazopyridine Derivatives as IL-17 Modulators - A series of substituted fused bicyclic imidazole derivatives, including imidazo[1,2-a]pyridine derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders. | 2022-07-21 |