29th week of 2011 patent applcation highlights part 39 |
Patent application number | Title | Published |
20110177536 | NOVEL ANTIBODIES RECOGNIZING NATIVE ANNEXIN A3 - The present invention refers to novel antibodies recognizing native annexin A3. These antibodies are suitable for diagnostic and therapeutic applications. | 2011-07-21 |
20110177537 | Method and System for Measuring a Sample to Determine the Presence of and Optionally Treat a Pathologic Condition - The present invention provides diagnostic in vitro methods as well as kits and devices to be used in the methods of the present invention for diagnosis or prognosis of a pathologic condition characterized by the presence/absence of an endogenous hormone and/or hormone analog(s) thereof involved in diabetes or metabolic syndrome. The methods comprise a quantitative separation of at least those analytes of interest whose common presence interferes with measuring the presence/absence or concentration of one of the analytes of interest by a subsequent analytical method. | 2011-07-21 |
20110177538 | BIOMARKERS FOR RHEUMATOID ARTHRITIS (RA) - The invention provides methods for predicting and compositions for use in the prediction of rheumatoid arthritis (RA) based upon the simultaneous measurement of at least two biomarkers in a biological sample. The invention further relates to methods for following the efficiency of a treatment against RA and to methods for identifying test substances that are likely to prevent or diminish RA. | 2011-07-21 |
20110177539 | COVALENTLY LINKED THERMOSTABLE KINASE FOR DECONTAMINATION PROCESS VALIDATION - A biological process indicator is provided for validating a treatment process in which the amount or activity of a contaminant in a sample is reduced. The indicator comprises a thermostable kinase covalently linked to a biological component, with the proviso that the biological component is not an antibody. Methods of preparing the indicator, and methods of using the indicator, are also provided. | 2011-07-21 |
20110177540 | MUTANT LUCIFERASE - An isolated recombinant luciferase having luciferase activity. The recombinant luciferase has an amino acid sequence which differs from the wild-type luciferase from | 2011-07-21 |
20110177541 | METHOD FOR ADJUSTING THE COAGULATION TIME IN CALIBRATOR OR CONTROL PLASMAS - A method for adjusting the coagulation time during the manufacture of calibrators and controls produced from frozen plasma or plasma treated for lyophilization thereof, for haemostatis tests relating to assaying and to monitoring anticoagulant treatments in a patient. The plasmas selected to prepare the calibrator plasmas or the control plasmas are treated with a view to lyophilization and supplemented with different predefined doses of a drug and a procoagulant factor. | 2011-07-21 |
20110177542 | METHOD FOR ENHANCING CELLOBIOSE UTILIZATION - The present invention relates to methods for improving a host cell's ability to utilize the disaccharide cellobiose. In some embodiments, a transformed cell expresses intracellular β-glucosidase. In other embodiments, a transformed host cell is able to grow on media wherein cellobiose is the sole carbon source. In other embodiments, selection methods are provided which improve a host cell's ability to grow on cellobiose-containing media. | 2011-07-21 |
20110177543 | REGULATION OF BACE DEGRADATION - The invention relates to methods and products for diagnosing, preventing, and treating Alzheimer's disease and abnormal production of amyloid β. | 2011-07-21 |
20110177544 | METHOD FOR DISTINGUISHING AND SORTING OF CELLS AND DEVICE THEREFOR - A method for distinguishing and sorting cells characterized by comprising distinguishing and sorting a specific cell mass or a part of the cells in the cell mass with the use of transmitted light data reflecting the morphological characteristics of the cells such as size and shape optionally together with side-scattering light data reflecting the characteristics of the internal structure of the cells. The part of the cells in the specific cell mass as described above are at the G1 stage or at a part of the M stage in the cell cycle. A part of the cells at the G1 stage are referred to as the left bottom line in an analytical dispersion diagram of the cells wherein the abscissa indicates the transmitted light data, while a part of the cells at the M stage are referred to as the right bottom line in the analytical dispersion diagram of the cells wherein the abscissa indicates the transmitted light data. | 2011-07-21 |
20110177545 | G-PROTEINS | 2011-07-21 |
20110177546 | METHOD OF DETECTING BIOACTIVE MOLECULES IN A FLUID SAMPLE - A method of detecting the presence of bioactive molecules in a fluid sample, comprising contacting a solution of a microorganism selected from the group consisting of a monocellular algae and a cyanobacteria with the fluid sample so as to obtain a formulation having a microorganism concentration of 200 000-1×10 | 2011-07-21 |
20110177547 | Particle Sorting Using Fluid Streams - A fluidic device includes an arrangement of channels for introducing a sample containing particles of interest into a processing chamber. The chamber is in fluid communication with collecting channels via low-flow connection channels. Particles in the sample may be observed and diverted from the processing chamber by application of a motive force such as optical trapping into a collection channel. Once in the collection channel, particles can be collected, including by trapping in a porous matrix. | 2011-07-21 |
20110177548 | Fluorescent microscope slide - An apparatus and method for increasing the efficiency of finding a field of focus, and for increasing the accuracy of field of view in reading slides with fluorescent microscopy technology, including tuberculosis slides. | 2011-07-21 |
20110177549 | METHOD, KIT AND SYSTEM FOR CULTURABLE CELL COUNT - The present invention provides a method, kit and system for determining a quantitative value indicative of the number of culturable microbial cells, such as | 2011-07-21 |
20110177550 | PROCESS FOR THE TREATMENT OF WATER AND PRODUCTION OF BIOMASS AND ASSOCIATED SYSTEMS - A process for the treatment of a saline water including: treating the water to adjust the salinity thereof and produce treated water having a predetermined salinity level; and directing at least a portion of the treated water having said predetermined salinity level to a bioreactor housing a microalgae for generating biomass; wherein said predetermined salinity level of the treated water is predicated by the specie of microalgae housed in the bioreactor. | 2011-07-21 |
20110177551 | METHOD FOR PRODUCING A CHEMICAL PRODUCT AND CONTINUOUS FERMENTATION APPARATUS - To control flow velocity of a culture liquid inside a membrane separation tank without giving influences to culture conditions in the fermentation tank, and also suppress precipitation of microorganisms or culture cells so that the production efficiency of the chemical product can be improved, in a method for producing a chemical product including the steps of: cultivating microorganisms or culture cells in a fermentation tank; transferring a culture liquid from the fermentation tank to a membrane separation tank so as to filter the culture liquid through a separation membrane; and collecting a fermentation product from a filtration liquid as the chemical product while refluxing an unfiltered culture liquid that has not been filtered so as to be joined to the culture liquid on an upstream side of the membrane separation tank, one portion of the culture liquid to be transferred from the fermentation tank is allowed to bypass the membrane separation tank depending on a pressure at the culture liquid flow-in side of the membrane separation tank. | 2011-07-21 |
20110177552 | SYSTEMS AND METHODS FOR PRODUCING PLASTID PROTEINS - Methods and systems that include a method comprising: providing a system comprising one or more plastid proteins comprising a signal sequence and one or more chloroplast processing enzymes; and allowing at least one of the one or more chloroplast processing enzymes to cleave at least a portion of a signal sequence from at least one of the one or more plastid proteins. | 2011-07-21 |
20110177553 | PREPARATION OF AN ESTERASE - The present invention relates to a recombinant | 2011-07-21 |
20110177554 | SECRETED FRIZZLED RELATED PROTEIN, SFRP, FRAGMENTS AND METHODS OF USE THEREOF - The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants. | 2011-07-21 |
20110177555 | CHINESE HAMSTER OVARY CELL LINES - We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with | 2011-07-21 |
20110177556 | Nucleic Acids Encoding Chimeric CD154 Polypeptides - The present invention provides for an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site of human CD154, and a second nucleotide sequence encoding an extracellular subdomain of human CD154 that binds to a human CD154 receptor. The present invention also provides for the chimeric CD154 that is encoded by the above-described polynucleotide sequence, an expression vector and a genetic vector comprising the polynucleotide sequence, a host cell comprising the expression vector or the genetic vector, a process for producing the chimeric CD154, and methods for utilizing the expression vectors and genetic constructs containing the chimeric CD154 polynucleotide sequences. | 2011-07-21 |
20110177557 | Fusion Protein and Use Thereof - The invention relates to a fusion protein and a method for the generation of the fusion protein of the invention. Further, the invention relates to the use of the fusion protein of the invention for the generation of induced pluripotent cells. Moreover, the invention relates to a composition comprising at least one fusion protein of the invention. | 2011-07-21 |
20110177558 | DISPERSING FEEDSTOCKS AND PROCESSING MATERIALS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is dispersed in a liquid medium and then saccharified. | 2011-07-21 |
20110177559 | PROCESSING MATERIALS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is saccharified in a vessel by operation of a jet mixer, the vessel also containing a liquid medium and a saccharifying agent. | 2011-07-21 |
20110177560 | Cellulosic Protein Expression in Yeast - The present invention provides for combinations of enzymes and other proteins that result in improved saccharification of plant material. The invention provides for saccharification in the presence of and optional fermentation by, yeast cells expressing the enzymes and other proteins. | 2011-07-21 |
20110177561 | Novel CBH1 Homologs And Varian CBH1 Cellulase - Disclosed are a number of homologs and variants of | 2011-07-21 |
20110177562 | Portable Preparation, Analysis, and Detection Apparatus for Nucleic Acid Processing - The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge. | 2011-07-21 |
20110177563 | HIGH THROUGHPUT DEVICE FOR PERFORMING CONTINUOUS-FLOW REACTIONS - A high-throughput device is structured to perform a continuous-flow reaction, e.g., a polymerase chain reaction (PCR) requiring repetitive temperature control in a timely fashion. | 2011-07-21 |
20110177564 | BIOPROCESS AND MICROBE ENGINEERING FOR TOTAL CARBON UTILIZATION IN BIOFUEL PRODUCTION - Some aspects of this invention provide methods and bioreactors for converting a carbon source into a lipid. In some embodiments, lipid production is carried out in an aerobic fermentor and carbon dioxide generated during lipid production is converted into a carbon substrate by CO | 2011-07-21 |
20110177565 | ISOLATED POLYPEPTIDE FOR INCREASING ACTIVITY OF POLYSACCHARIDE HYDROLASE AND METHODS OF USE - An isolated polypeptide is disclosed that improves the hydrolyzing capacity of a polysaccharide hydrolase such as cellulase, is capable of binding to a polysaccharide, is deficient in polysaccharide hydrolase activity, and includes a GH45 or a pollen-allergen domain. Methods of hydrolyzing polysaccharides using the isolated polypeptide are also disclosed. | 2011-07-21 |
20110177566 | METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY - A method for producing an L-amino acid is described using a bacterium of the Enterobacteriaceae family, wherein the bacterium contains a protein which is able to confer resistance to growth inhibition by L-cysteine. | 2011-07-21 |
20110177567 | MILD ALKALINE PRETREATMENT AND SIMULTANEOUS SACCHARIFICATION AND FERMENTATION OF LIGNOCELLULOSIC BIOMASS INTO ORGANIC ACIDS - The invention relates to a method for the production of a fermentation product from lignocellulosic biomass, to a reactor to carry out the method and to use of the reactor to produce a fermentation product. | 2011-07-21 |
20110177568 | Method of L-Lysine Production - The present invention relates to a method of microbial production of L-lysine from methanol and other substrates, and particularly improving the production of L-lysine from such substrates. The invention concerns a method for producing lysine in | 2011-07-21 |
20110177569 | MUTANT OF PROPIONYL-COA TRANSFERASE FROM CLOSTRIDIUM PROPIONICUM AND PREPARING METHOD FOR PLA OR PLA COPOLYMER USING THE SAME - Provided is a mutant of propionyl-CoA transferase from | 2011-07-21 |
20110177570 | BACTERIAL MUTANTS FOR ENHANCED SUCCINATE PRODUCTION - The present invention relates to a method for obtaining enhanced metabolite production in micro-organisms, and to mutants and/or transformants obtained with said method. More particularly, it relates to bacterial mutants and/or transformants for enhanced succinate production, especially mutants and/or transformants that are affected in the import and export of succinate. | 2011-07-21 |
20110177571 | DESIGNER CALVIN-CYCLE-CHANNELED PRODUCTION OF BUTANOL AND RELATED HIGHER ALCOHOLS - Designer Calvin-cycle-channeled and photosynthetic NADPH-enhanced pathways, the associated designer genes and designer transgenic photosynthetic organisms for photobiological production of butanol and related higher alcohols from carbon dioxide and water are provided. The butanol and related higher alcohols include 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol, 5-methyl-1-hexanol, and 6-methyl-1-heptanol. The designer photosynthetic organisms such as designer transgenic oxyphotobacteria and algae comprise designer Calvin-cycle-channeled and photosynthetic NADPH-enhanced pathway gene(s) and biosafety-guarding technology for enhanced photobiological production of butanol and related higher alcohols from carbon dioxide and water. | 2011-07-21 |
20110177572 | Method of Cultivating Fermentative Yeast Used for Xylose Fermentation of Non-Detoxified Lignocellulosic Hydrolysate - A hydrolysate-adapted yeast, | 2011-07-21 |
20110177573 | Microbial Treatment of Lignocellulosic Biomass - Aspects of the present invention relate to methods of microbially treating lignocellulosic biomass using cellulose- and/or hemicellulose-degrading bacteria. In certain embodiments, the microbially treated material is then subjected to thermal and/or chemical pretreatment. In tandem with the microbial treatment the thermal and/or chemical pretreatment may result in the production of fewer degradation products, thereby allowing for higher overall yields of ethanol per ton of starting biomass. | 2011-07-21 |
20110177574 | Method and Apparatus for Processing Waste Containing Fermentable Raw Material - The invention relates to a method and an apparatus for processing waste ( | 2011-07-21 |
20110177575 | PRODUCTION OF HYDROCARBONS IN MICROORGANISMS - A recombinant microorganism employing a bacterial pathway to produce a cyclic amino acid (e.g., coronamic acid or norcoronamic acid) and a plant enzyme (ACC oxidase) to oxidize the amino acid and produce an alkene (e.g., 1-butene or propene) is provided herein. Expression of these two biosynthetic modules in various microbial chassis will facilitate alkene production from diverse energy and carbon sources, including sugars, glycerol, CO | 2011-07-21 |
20110177576 | SHOCK WAVE CELL TREATMENT DEVICE AND METHOD TO ENHANCE CELL REPLICATION | 2011-07-21 |
20110177577 | ENHANCEMENT OF VANADIUM-CONTAINING PHOSPHATASE INHIBITORS - The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for inhibiting a phosphatase, as well as kits comprising the composition. | 2011-07-21 |
20110177578 | APTAMER AGAINST IL-17 AND USE THEREOF - The invention provides an aptamer possessing an inhibitory activity against IL-17, as well as a complex comprising an aptamer possessing a binding activity or inhibitory activity against IL-17 and a functional substance (for example, affinity substances, substances for labeling, enzymes, drug delivery vehicles, drugs and the like). The invention also provides a pharmaceutical drug, cell migration inhibitor, diagnostic reagent, detection probe, carrier, labeling agent, and the like comprising the aforementioned aptamer or complex, and methods of detecting and purifying IL-17 by using the aforementioned aptamer or complex. | 2011-07-21 |
20110177579 | Thermostable Alcohol Dehydrogenase Derived From Thermococcus Guaymasensis - An alcohol dehydrogenase (ADH) from hyperthermophilic archaeon | 2011-07-21 |
20110177580 | Method of Controlling a Polypeptide Modification Reaction - The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation of human factor VII (FVII) to produce human factor VII(a) (FVII(a)). The invention also relates to polypeptides obtainable by the polypeptide modification reaction and to pharmaceutical compositions comprising said polypeptides. | 2011-07-21 |
20110177581 | Mutant MT-SP1 proteases with altered substrate specificity or activity - MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis. | 2011-07-21 |
20110177582 | PRODUCTION OF PROTEIN ISOLATES - Embodiments of the process for isolating proteins from a defatted meal comprise extracting the defatted meal with an acidic solvent at a pH of between 2 and 6 to obtain a mixture of treated meal and a first solution of proteins. The process further comprises extracting the treated meal with an alkaline solvent at a pH of between 9 and 12.5 to obtain a mixture of meal residue and a second solution of proteins. The meal residue is separated from the second solution of proteins, and the proteins are separated from the second solution of proteins to obtain one or more protein products. | 2011-07-21 |
20110177583 | Automated rinse water and body fluid bioagent detection - Testing of the foot soldier or other person on the battlefield for bioagent contamination is facilitated by a computer controlled portable testing unit that combines a sink or other receptacle ( | 2011-07-21 |
20110177584 | ACOUSTIC WAVE SENSOR AND DETECTION METHOD USING ACOUSTIC WAVE SENSOR - An acoustic wave sensor having significantly increased sensitivity and excellent sensing reproducibility and stability includes a piezoelectric substrate, an acoustic wave element including an electrode disposed on the piezoelectric substrate, and a reactive membrane which overlies the acoustic wave element and which is reduced in mass by direct or indirect chemical reaction with a measured substance. The measured substance is detected such that a change in mass applied to the acoustic wave element from the reactive membrane is detected by a change in frequency. | 2011-07-21 |
20110177585 | RAPID DETECTION NANOSENSORS FOR BIOLOGICAL PATHOGENS - An apparatus for the rapid detection of multiple pathogens using a FRET-based phenomenon. A volume of fluid, possibly containing pathogens, is passed through an intake and combined with an assay solution of quantum dot/antibody-antigen/quencher complexes that dissociate and recombine with the pathogens into quantum dot/antibody-pathogen complexes. The quantum dot/antibody-antigen/quencher and quantum dot/antibody-pathogen complexes are captured on a detection filter which is illuminated by a light source. The quantum dot/antibody-pathogen complexes, but not the quantum dot/antibody-antigen/quencher complexes, fluoresce when excited by the light from the light source and the fluorescence is picked up by a photodetector, indicating the presence of the pathogens. | 2011-07-21 |
20110177586 | DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT - The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. | 2011-07-21 |
20110177587 | NUCLEIC ACID AMPLIFICATION WITH CONTINUOUS FLOW EMULSION - Embodiments of the present invention are directed to methods and devices/systems for amplifying genetic material and may include providing a water-in-oil emulsion in a continuous flow. The emulsion may include a plurality of water droplets comprising microreactors. Each of the plurality of microreactors may include a single bead capable of capturing a nucleic acid template, a single species nucleic acid template and sufficient reagents to amplify the copy number of the nucleic acid template. The method also includes flowing the emulsion across a first temperature zone and a second lower temperature zone to thermally process the microreactors to amplify the nucleic acid template by polymerase chain reaction. | 2011-07-21 |
20110177588 | METHOD AND APPARATUS FOR DISRUPTING CELLS AND PURIFYING NUCLEIC ACID USING A SINGLE CHIP - Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a solid support on which a cell lysis enhancing metal oxide layer, and a cell binding metal oxide layer have been deposited. | 2011-07-21 |
20110177589 | NOVEL HUMAN POLYOMAVIRUS - Provided herein is a novel human polyomavirus, its nucleic acid sequence, as well as methods to detect and diagnosis the presence of the polyomavirus. | 2011-07-21 |
20110177590 | Bioprinted Nanoparticles and Methods of Use - The present invention provides compositions and methods that combine the initial patterning capabilities of a direct cell printing system with the active patterning capabilities of magnetically labeled cells, such as cells labeled with superparamagnetic nanoparticles. The present invention allows for the biofabrication of a complex three-dimensional tissue scaffold comprising bioactive factors and magnetically labeled cells, which can be further manipulated after initial patterning, as well as monitored over time, and repositioned as desired, within the tissue engineering construct. | 2011-07-21 |
20110177591 | METHOD AND DEVICE FOR PRODUCING DERMIS - A process and a device for preparing a dermis implant of a predefinable thickness provides for a section of skin ( | 2011-07-21 |
20110177592 | MAGNETIC APPARATUS FOR BLOOD SEPARATION - An apparatus for magnetically separating constituents of blood includes: a first portion having a solid support haying fixedly attached thereon a plurality of ring magnets, each ring magnet defining an interior perimeter enclosing an aperture; and a second portion removably attached to the first portion, wherein the second portion includes a solid substrate having surfaces defining a plurality of second apertures, each second aperture configured to removably hold a vial. | 2011-07-21 |
20110177593 | LOW RIGIDITY GELS FOR MSC GROWTH MODULATION - This invention provides gels and matrices having a rigidity in the range of 0.1-2.5 kPa, methods of manufacturing same, and method of preserving a mesenchymal stem cell population or studying mesenchymal stem cells, comprising same. | 2011-07-21 |
20110177594 | STEM CELLS CULTURE SYSTEMS - Provided are systems and methods for providing human cell cultures. Further provided are cultures of feeder cells for use in stem cell technology, as well as cultures, culture systems and methods for maintenance and propagating of stem cells in an undifferentiated state as well as for the development of somatic cells cultures from stem cells, the somatic cell cultures being free of extraembryonic cells. | 2011-07-21 |
20110177595 | Multipotent Adult Stem Cells, Sources Thereof, Methods of Obtaining and Maintaining Same, Methods of Differentiation Thereof, Methods of Use Thereof and Cells Derived Thereof - Methods and compositions are provided for circularizing target sequences in a sample. In particular, ligation oligonucleotides are employed to selectively hybridize with the target such that the target can be ligated into a closed circular target. Rolling circle amplification can then be performed directly on the target sequence for subsequent detection and analysis. | 2011-07-21 |
20110177596 | Device for enhancing immunostimulatory capabilities of T-cells - T-cells are generated with enhanced immunostimulatory capabilities for use in self therapy treatment protocols, by utilizing a biodegradable device with a biodegradable support that has one or more agents that are reactive to T-cell surface moieties. The biodegradable devices are mixed with the T-cells sufficiently so that the one or more agents cross-link with the T-cells' surface moieties and deliver a signal to the T-cells to enhance immunostimulatory capabilities. | 2011-07-21 |
20110177597 | CELLULAR DIFFERENTIATION PROCESS AND ITS USE FOR BLOOD VESSEL BUILD-UP - A process of differentiation of stem cells through the use of specific oxygen concentrations, provided that the stem cells are not human embryonic stem cells, and seeded on a support, in an appropriate culture medium, wherein the differentiation leads to:
| 2011-07-21 |
20110177598 | METHOD FOR CELLULAR TISSUE MULTIPLICATION FROM JATROPHA CURCAS - The method of the present invention comprises: Obtaining an explant from the seeds of | 2011-07-21 |
20110177599 | DELIVERY OF NUCLEIC ACIDS ACROSS MEMBRANES - The present invention provides for methods and compositions for introducing integral membrane proteins into cell membranes and, optionally, delivery of nucleic acids across membranes via the integral membrane proteins. | 2011-07-21 |
20110177600 | PROTEIN PRODUCTION USING EUKARYOTIC CELL LINES - The subject invention provides a site-specific integration system and methods for generating eukaryotic cells lines for protein production. The provided system includes a first site-specifically integrating target vector and a second site-specifically integrating donor vector comprising a gene of interest. Also provided are mammalian cell lines produced by the subject methods and systems, as well as kits that include the subject systems. | 2011-07-21 |
20110177601 | METHOD FOR CONCENTRATION OF LOW-MOLECULAR-WEIGHT PROTEINS AND PEPTIDES IN BODY FLUID SAMPLE - A method for extracting low-molecular-weight proteins/peptides contained in a body fluid sample, particularly, in serum or plasma. The method includes the steps of (a) to (e): (a) adding reagent 1 containing urea and thiourea and reagent 2 containing a reducing agent to the body fluid sample, mixing them, subsequently dropping the mixture into reagent 3 containing 90% or more of an organic solvent, and mixing them; (b) stirring at a low temperature the mixed solution obtained in step (a); (c) centrifuging at a low temperature the stirred solution obtained in step (b) and removing the supernatant; (d) adding reagent 4 containing an organic solvent and an acid to the precipitate obtained in step (c) and mixing them; (e) stirring at a low temperature the mixed solution obtained in step (d); and (f) centrifuging at a low temperature the stirred solution obtained in step (e) and recovering the supernatant. | 2011-07-21 |
20110177602 | Composite Structure - A composite structure, for marking biomolecules in a biological, biochemical or medicinal system, comprises: at least one nano particle and at least one dendritic macromolecule, which has an inner region with branched, especially perfectly branched to highly branched, structures and a periphery, which comprises surface groups of the dendritic macromolecule, wherein a plurality, especially more than 50%, of the surface groups have in the periphery of the dendritic macromolecule, in each case, at least one functional group of first type, wherein the functional group of first type comprises at least one monosaccharide-, oligosaccharide- and/or polysaccharide unit, and wherein the dendritic macromolecule stabilizes the nano particle. | 2011-07-21 |
20110177603 | ULTRASONIC TEST EQUIPMENT - An ultrasonic test equipment includes a water tank for storing ultrasonic medium, an ultrasonic probe provided in the water tank, an ultrasonic medium temperature sensor configured to measure a first temperature of the ultrasonic medium, a test object temperature sensor configured to measure a second temperature of a test object, and a temperature control device. The temperature control device heats the ultrasonic medium or cools the test object such that the first temperature becomes equal to or higher than the second temperature. Gas bubbles are prevented from emerging on a surface of the test object. | 2011-07-21 |
20110177604 | METHOD FOR DETECTING LEAD PRESENT IN SPECIMEN - With respect to a lead detection method that uses rhodizonic acid, it is made possible to clearly identify pink or red coloration caused by a reaction between lead and rhodizonic acid even in cases where Sn is present in a specimen. To this end, an acidic aqueous solution or a buffer solution thereof (e.g., tartaric acid) in which hydrogen peroxide coexists is used as a reagent. Hydrogen peroxide oxidizes Sn | 2011-07-21 |
20110177605 | On-Board Control for Analytical Elements - The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element. | 2011-07-21 |
20110177606 | DETECTION OF TRINITROTOLUENE - An ultrasensitive method for detecting analytes in a sample is provided. The method involves the use of a matrix of nanoparticles which are associated with recognition groups capable of undergoing interaction with the analyte. | 2011-07-21 |
20110177607 | Method for assaying sulfur and apparatus therefor - The present invention relates to a sulfur assaying method comprising converting carbon monoxide in a sample gas generated by combustion of the sample to nitrogen dioxide by a pretreatment, and then measuring the intensity of fluorescence of sulfur dioxide in the sample gas, the pretreatment comprising irradiating the sample gas with light from a low pressure mercury lamp, and also relates to a sulfur assaying apparatus comprising a combustor ( | 2011-07-21 |
20110177608 | METHOD AND COMPOSITION FOR DETERMINING HARDNESS IN WELLBORE FLUID FILTRATE - Disclosed herein is an indicator precursor composition for determining the hardness of a wellbore fluid filtrate comprises a colorimetric indicator and a buffer comprising a salt of a weak acid and a strong base, wherein the indicator precursor composition is a dry solid. Also disclosed is a method to determine the hardness of a wellbore fluid filtrate. | 2011-07-21 |
20110177609 | DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT - The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. | 2011-07-21 |
20110177610 | NOVEL MARKER FOR ARTERIOSCLEROTIC DISEASE - Disclosed is a novel marker for an arteriosclerotic disease. Also disclosed is a method for evaluating the presence or level of an arteriosclerotic disease in a mammal, or a method for evaluating the prophylactic or therapeutic effect on an arteriosclerotic disease in a mammal, which is characterized by detecting a soluble LR11 in a sample collected from the mammal. | 2011-07-21 |
20110177611 | LIGAND BINDING DOMAINS OF NUCLEAR RECEPTORS IN CONTROLLABLE FORM AND METHODS INVOLVING THE SAME - The present invention relates to an isolated protein comprising a ligand binding domain of a nuclear receptor in controllable form, a method of producing the same, its use for the identification of a ligand, a test system comprising the isolated protein and a method for screening for a ligand for a nuclear receptor using the test system. | 2011-07-21 |
20110177612 | Human G Protein-Coupled Receptors and Modulators Thereof for the Treatment of Metabolic-Related Disorders - The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other preferred embodiments, the GPCR is coupled to Gi and lowers the level of intracellular cAMP. In other preferred embodiments, the GPCR is expressed endogenously by adipocytes. In further preferred embodiments, the GPCR inhibits intracellular lipolysis. In other further preferred embodiments, the GPCR is a nicotinic acid receptor. The present invention also relates to methods of using a modulator of said GPCR. Preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, stroke, insulin resistance, and type 2 diabetes. | 2011-07-21 |
20110177613 | Use of periostin as a novel biomarker - The invention provides, in certain embodiments, a method of detecting an indicator of renal injury or renal disease. The method entails assaying a urine sample for periostin, wherein the presence of periostin at an elevated level indicates the presence and/or degree of renal injury or renal disease. Also provided, are methods of determining progression of these conditions, as well as methods of determining subjects' response to treatment. | 2011-07-21 |
20110177614 | COMPOSITIONS AND METHODS FOR DETECTING CANCER - The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer. | 2011-07-21 |
20110177615 | PROTEIN EXPRESSION - The present invention is concerned with improved expression of recombinant proteins, in particular fusion proteins, and methods for their expression. The present invention is also concerned with proteins for use in detection assays, and especially for directed surface immobilisation. | 2011-07-21 |
20110177616 | Diagnostic Test Kits Employing an Internal Calibration System - A diagnostic test kit that employs a lateral flow assay device and a plurality of assay reagents for detecting a test analyte within a test sample is disclosed. The assay reagents include detection probes that are capable of producing a detection signal representing the presence or quantity of the test analyte in the test sample. To further enhance detection accuracy, calibration probes are also used that are capable of producing a calibration signal representing the presence or quantity of a calibration analyte. The calibration signal may be utilized to calibrate the detection signal. | 2011-07-21 |
20110177617 | CROSS-LINKING REAGENTS FOR MOLECULAR INTERACTIONS ANALYSIS - The invention describes the use of particular cross-linking reagents containing 1-hydroxybenzotriazole or 1-hydroxy-7-azabenzotriazole groups as reactive groups for cross-linking reactions of supramolecular target-ligand-complexes. The resulting cross-linked products may be directly analyzed using mass spectrometry, gel or fluorescence based technologies, X-ray crystallography, NMR or other analytical technologies. The method using High-Mass MALDI mass spectrometry provides various biological applications such as characterization of antibodies, drug discovery, and protein complex analysis including automated or higher throughput applications. | 2011-07-21 |
20110177618 | Multi-Directional Microfluidic Devices and Methods - Multi-directional microfluidic devices and methods for using the same are provided. Aspects of the invention include microfluidic devices that are configured to subject a sample to two or more directionally distinct flow fields, and include a separation medium and a binding medium, where the binding medium is in fluid communication with the separation medium. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays. | 2011-07-21 |
20110177619 | IN VITRO DIAGNOSTIC MARKERS COMPRISING CARBON NANOPARTICLES AND KITS - This invention relates to luminescent markers for in vitro diagnostic applications, and kits using those markers. In some embodiments, those markers comprise luminescent carbon nanoparticles. Some embodiments provide a method for investigating an analyte comprising correlating a marker to the analyte and observing the luminescence from the marker, wherein the marker comprises a nanoparticle having a carbon core. In vitro kits, including those employing a marker comprising a nanoparticle having a carbon core, are also provided. | 2011-07-21 |
20110177620 | BIOANALYTICAL ASSAY - A nanoparticle having a detectible feature and whose diameter is less than 200 nm, and which is coated with multiple specific binding reactants such that the affinity constant of the nanoparticle towards an analyte exceeds that of free binding reactant towards the analyte and/or the association rate constant between the nanoparticle and the analyte exceeds the association rate constant between the free binding reactant and the analyte. Also disclosed is a homogenous assay based on a first group labeled with a luminescent energy donor nanoparticle and a second group labeled with an energy acceptor compound, where the donor has a long excited state lifetime, and the increase or decrease, respectively, in the energy transfer from the donor to the acceptor resulting from shortening or lengthening, respectively, of the distance between these groups, is measured. | 2011-07-21 |
20110177621 | MAGNETIC MEMORY CELL CONSTRUCTION - A magnetic tunnel junction cell having a free layer, a ferromagnetic pinned layer, and a barrier layer therebetween. The free layer has a central ferromagnetic portion and a stabilizing portion radially proximate the central ferromagnetic portion. The construction can be used for both in-plane magnetic memory cells where the magnetization orientation of the magnetic layer is in the stack film plane and out-of-plane magnetic memory cells where the magnetization orientation of the magnetic layer is out of the stack film plane, e.g., perpendicular to the stack plane. | 2011-07-21 |
20110177622 | APPARATUS AND METHODS OF MIXING AND DEPOSITING THIN FILM PHOTOVOLTAIC COMPOSITIONS - Improved methods and apparatus for forming thin-film layers of semiconductor material absorber layers on a substrate web. According to the present teachings, a semiconductor layer may be formed in a multi-zone process whereby various layers are deposited sequentially onto a moving substrate web. At least one layer is deposited from a mixed gallium indium source. | 2011-07-21 |
20110177623 | Active Tribology Management of CMP Polishing Material - An arrangement and method for managing the tribology associated with a chemical mechanical planarization (CMP) process continuously monitors and modifies the properties of a polishing slurry in order to assist in controlling the removal rate associated with the CMP process. The viscosity of slurry as it leaves the CMP system (“spent slurry”) and the material removal rate associated with the semiconductor wafer are measured, and then the viscosity of the incoming slurry is adjusted if the measured material removal rate differs from a desired removal rate. If the removal rate is considered to be too fast, the viscosity of the fresh slurry being dispensed onto polishing pad is decreased; alternatively, if the removal rate is too slow, the viscosity is increased. As an alternative to modifying the viscosity of the slurry (or, perhaps in addition to modifying the viscosity), a lubricant may be added to the slurry to slow down the removal rate. | 2011-07-21 |
20110177624 | WORKPIECE BREAKAGE PREVENTION METHOD AND APPARATUS - Methods and apparatus for heat-treating a workpiece are disclosed. An illustrative method includes measuring deformation of a workpiece during heat-treating thereof, and taking an action in relation to the heat-treating of the workpiece, in response to the measuring of the deformation of the workpiece. The workpiece may include a semiconductor wafer. Taking an action may include applying a deformation correction to a temperature or reflectivity measurement of the wafer during thermal processing, or may include modifying the heat-treating of the wafer, for example. | 2011-07-21 |
20110177625 | METHOD AND APPARATUS FOR IDENTIFYING THE CHEMICAL COMPOSITION OF A GAS - Embodiments of the present invention relate to the analysis of the components of one or more gases, for example a gas mixture sampled from a semiconductor manufacturing process such as plasma etching or plasma enhanced chemical vapor deposition (PECVD). Particular embodiments provide sufficient power to a plasma of the sample, to dissociate a large number of the molecules and molecular fragments into individual atoms. With sufficient power (typically a power density of between | 2011-07-21 |
20110177626 | Method Of Determining An Amount of Impurities That A Contaminating Material Contributes To High Purity Silicon And Furnace For Treating High Purity Silicon - A method of determining an amount of impurities that a contaminating material contributes to high purity silicon comprises the step of partially encasing a sample of high purity silicon in the contaminating material. The sample encased in the contaminating material is heated within a furnace. A change in impurity content of the high purity silicon is determined after the step of heating, compared to an impurity content of the high purity silicon prior to the step of heating. A furnace for heat treating high purity silicon comprises a housing that defines a heating chamber. The housing is at least partially formed from low contaminant material that contributes less than 400 parts per trillion of impurities to the high purity silicon during heating at annealing temperatures for a sufficient period time to anneal the high purity silicon, and the furnace contributes an average of less than 400 parts per trillion of impurities to the high purity silicon under the same heating conditions. | 2011-07-21 |
20110177627 | ASSEMBLY LINE FOR PHOTOVOLTAIC DEVICES - The present application provides a method for the production of photovoltaic devices, preferably tandem solar cells. The method comprises the steps of: Providing at least one substrate comprising a front contact; and depositing at least a first semiconductor stack onto the substrate to produce a photo-voltaic device; and comprises at least two of the steps of: applying a back contact to the photovoltaic device; contacting of the photovoltaic device; removal of unnecessary material from the edge regions of the photovoltaic device; encapsulation; cross-contacting; and/or framing of the photovoltaic device, wherein the substrate is continuously or semi-continuously moved from one step of the method to the next step of the method. The present application furthermore provides a system to carry out the method of the invention. | 2011-07-21 |
20110177628 | LIGHT EMITTING DEVICE FABRICATING APPARATUS AND LIGHT EMITTING DEVICE FABRICATING METHOD USING THE SAME - Provided is a light emitting device fabricating apparatus, which includes a light emitting device, first and second contact parts, a power source part, a loading plate, and a chamber. The first and second contact parts are connected to the light emitting device to apply a first current to the light emitting device. The power source part supplies power to the first and second contact parts. The loading plate supports and heats the light emitting device. The chamber accommodates the light emitting device, the first and second contact parts, and the loading plate, and has a vacuum state or oxygen atmosphere. | 2011-07-21 |
20110177629 | Chip Packaging with Metal Frame Pin Grid Array - A packaging technology for silicon chips is similar to ball grid array packaging technology of the prior art without, however, the use of printed board substrate of the prior art Instead pins are used that are part of a planar frame, the pins folded to a position 90 degrees from the plane of the frame, after which the frame is disposed in contact with the chip, pads on the frame and the chip are connected, and then entire assembly is then encapsulated. The edges of the frame are then cut off, leaving the encapsulation to maintain the configuration of the package in place. | 2011-07-21 |
20110177630 | COMPLEX SALTS - Disclosed is a salt of an organometallic complex cation and an organometallic complex anion, wherein the cation as well as the anion consists of a central metal atom M of atomic weight greater than 40 associated to 2 or more ligands, at least one ligand comprising a cyclic organic moiety with a carbon atom bonding to M, and at least one ligand comprising a cyclic organic moiety with a nitrogen atom bonding to M. The novel salts may be used as conductive and/or light emitting components in electronic devices. Color emission may be chosen by selecting anion(s) and cation(s) of suitable emission characteristics. | 2011-07-21 |
20110177631 | METHOD OF FORMING A COMPOSITE SUBSTRATE AND GROWING A III-V LIGHT EMITTING DEVICE OVER THE COMPOSITE SUBSTRATE - A method according to embodiments of the invention includes providing a substrate comprising a host and a seed layer bonded to the host. The seed layer comprises a plurality of regions. A semiconductor structure comprising a light emitting layer disposed between an n-type region and a p-type region is grown on the substrate. A top surface of a semiconductor layer grown on the seed layer has a lateral extent greater than each of the plurality of seed layer regions. | 2011-07-21 |
20110177632 | OPTICAL DEVICE AND METHOD OF MANUFACTURING THE SAME - An optical device includes a semiconductor substrate ( | 2011-07-21 |
20110177633 | METHOD FOR MANUFACTURING SEMICONDUCTOR LIGHT-EMITTING DEVICE - A method for manufacturing a resin-embedded semiconductor light-emitting device that is capable of preventing a semiconductor film from being damaged when a growth substrate is delaminated using a laser lift-off method, and that is capable of preventing foreign matter from adhering to the semiconductor film when a resin material is applied. A laser exposure step to delaminate the growth substrate from the semiconductor film comprises a first laser exposure step for performing laser exposure at an energy density at which the resin is broken down but the semiconductor film is not broken down, in a range including a portion adjacent to at least one section of the semiconductor film divided by dividing grooves and at least one section of resin, and a second exposure step for performing laser exposure at an energy density at which the semiconductor film can be broken down in a range including at least one section. | 2011-07-21 |
20110177634 | Edge-Emitting Semiconductor Laser Chip - A method for manufacturing an edge emitting semiconductor laser chip, which has a carrier substrate, an interlayer arranged between the carrier substrate and a component structure of the edge emitting semiconductor laser chip. The interlayer is adapted to provide adhesion between the carrier substrate and the component structure. The component structure has an active zone provided for generating radiation. | 2011-07-21 |
20110177635 | LIGHT EMITTING DEVICE AND METHOD FOR MANUFACTURING THE SAME - A light emitting device includes: a substrate having a concave portion formed on a surface thereof; a light emitting element emitting a first light which is a blue light or a near-ultraviolet light; a resin sheet being a deformable resin sheet formed on the substrate so as to cover the light emitting element; a first transmissive layer formed in a hemispherical shape on the first region of the resin sheet, and transmitting the first light; a color conversion layer including a fluorescent material that converts the first light into a second light of a different wavelength from that of the first light and a transmissive material that transmits the first light, the color conversion layer covering the first transmissive layer in such a manner that an end portion reaches an upper face of the resin sheet; and a second transmissive layer covering the color conversion layer in such a manner that an end portion reaches the upper face of the resin sheet, and transmitting the first light and the second light. | 2011-07-21 |