29th week of 2013 patent applcation highlights part 42 |
Patent application number | Title | Published |
20130184124 | PORTABLE MODULAR HANGING AND PULLING SYSTEM - One embodiment of the present invention relates to a portable modular hanging and pulling system comprising a first and second bearing member, two coupling members, and a modular surface. The coupling members may be elongated U-shaped rigid support type structures. The first and second bearing members may be coupled at independent lengthwise locations along the coupling members corresponding to the left and bottom regions of the U-shape. The modular surface may be coupled to the coupling members at a lengthwise location corresponding to the right region of the U-shape. The modular surface may include a grid of at least four coupling recesses configured to releasable couple gripping regions including various shaped holds, hangboards, features, accessories, etc. | 2013-07-18 |
20130184125 | Endless Belt Multi-function Training System - A training apparatus having an endless belt is provided. The apparatus provides a treadmill operable to simulate a variety of high intensity exercises. In particular, the apparatus is designed to simulate high intensity pushing and pulling exercises. The system includes forward and rearward mounts for attaching accessories to facilitate various training exercises. The system also includes a drive control with multiple flywheels for providing variable resistance to rotation of the treadmill. | 2013-07-18 |
20130184126 | LOWER LEG AND FOOT EXERCISE DEVICE - An exercise device for a lower leg and foot is provided. The exercise device provides a user with the ability to exercise multiple muscles in both lower legs and both feet, and provides the user with multiple exercises with a single exercise device. Additionally, the exercise device is capable of providing variable resistances during exercise to accommodate users of different strength and to accommodate a user's increase in strength. To provide variable resistance, the exercise device includes a plurality of resilient resistance member interchangeably coupled to a housing of the exercise device. | 2013-07-18 |
20130184127 | BACK STRETCHING MACHINE - An apparatus for stretching the lower back includes a waist garment configured for placement around a person's waist. It also includes at least one stretchable elastic element for interconnecting the waist garment with a surface. The elastic element is stretchable when interconnecting the waist garment with the surface from a materially biased configuration by a person wearing the waist garment and tensioning the stretchable elastic element by pushing away from the surface to thereby apply force to the person's back via the waist garment. The apparatus also includes at least one foot support element against which a person can push his foot to push away from the surface, thus imposing a therapeutic force on his lower back. | 2013-07-18 |
20130184128 | EXERCISE MACHINE FOR PROVIDING WEIGHT LIFTING EXERCISES SIMILAR TO THOSE PROVIDED BY A FREE WEIGHT BARBELL - An exercise machine for performing barbell type free weight lifting exercises has a power cage or Smith press type frame, an elongated bar held on the frame in a substantially horizontal resting position, and an adjustable exercise mass assembly that allows a user to select an exercise weight from among a plurality of choices of different exercise weights provided by the exercise mass assembly. The exercise mass assembly is separate from the bar and any auxiliary weight plates carried on the bar. A cable and pulley system operatively connects the bar to a movable portion of the exercise mass assembly that provides the selected exercise weight. A powered actuator sets up the bar for performing a weight lifting exercise by lifting the movable portion of the exercise mass assembly up above a second portion of the exercise mass assembly that remains stationary during the particular weight lifting exercise. | 2013-07-18 |
20130184129 | EXERCISE EQUIPMENT - Exercise equipment comprising a grippable handle at which said exercise equipment can be lifted by a user, and at least one docking assembly connected to the grippable handle. The docking assembly has opposing arms that define a slot in which at least one weight plate can be removably mounted. At least one locking member is located on the docking assembly to capture and/or lock at one weight plate to the docking assembly once received in the slot. | 2013-07-18 |
20130184130 | EXERCISE DEVICE FOR TORSO ROTATION AND METHOD OF OPERATING THE SAME - Embodiments of the disclosed subject matter relate to an exercise device for torso rotations. The device includes a rotating assembly including an inclined, elevated, backwardly-oriented back rest and optionally a head rest and an arm assembly. The rotating assembly is configured to a effect a side-to-side rotation around a pivot point elevated above a base of the device and around an axis oriented along the device. When the user leans weight his upper back on the back rest to elevate his/her upper back, s/he may effect torso rotations that, in some embodiments, are resisted by a resistance assembly of the exercise device. | 2013-07-18 |
20130184131 | DEVICE AND METHOD FOR PERFORMING EXERCISES USING A FREELY ROTATING BALL - Exemplary embodiments of an exercise apparatus and its method of use are provided. An exercise apparatus can be provided having a resilient ball configured to support a weight of a user performing exercises thereon, and a shell member configured to cover at least an upper portion of the resilient ball. The shell member can have an inner surface conforming to an outer surface of the resilient ball. A toroidal member can be provided that can be attached to the shell member and can surround a portion of the resilient ball. | 2013-07-18 |
20130184132 | MOUNTING UNIT FOR A TOOL DEPOSITING DEVICE - A mounting unit for a tool depositing device includes a coupling carrier having a tool-side coupling element, in particular for a coupling device for a tool of a robot, and a holding device that can be connected to a mounting plate of the tool depositing device. An intermediate space is provided between the holding device and the coupling carrier to allow compensating movements between the coupling carrier and the holding device. The holding device includes two guide rails, between which the coupling carrier is pushed in. An interlocking engagement between the coupling carrier and the guide rails is produced by engaging at least one protuberance in at least one recess, wherein the at least one recess and the at least one protuberance are arranged on mutually opposing sides of the coupling carrier and of the guide rails. | 2013-07-18 |
20130184133 | DEFECTIVE PRODUCT REMOVING DEVICE FOR BOX MAKING MACHINE AND BOX MAKING MACHINE - There is provided a defective product removing device for a box macking machine that removes a sheet material as a defective product from a manufacturing line for manufacturing a box by processing the sheet material, the defective product removing device including: a quality determining device for determining the quality of the sheet material based on a predetermined inspection result with respect to the sheet material conveyed in the manufacturing line; a defective product removing portion for removing the sheet material of which a surface is subjected to creasing processing and slotting and which is not folded yet from the manufacturing line; and a sorting device for operating the defective product removing portion with respect to the sheet material determined as a defective product by the quality determining device. | 2013-07-18 |
20130184134 | BOX PRODUCING APPARATUS, INSPECTION UNIT, AND PRINT REGISTER CONTROL METHOD FOR A BOX PRODUCING APPARATUS - An box producing apparatus is disclosed, including a camera that obtains an image of a printed face which is printed on a box material sheet by the printing section; and a register correction control unit that compares a specific picture in a master image of a sample for the print, and a picture in a region specified according to the specific picture in the image of the printed face obtained by the camera to determine an amount of register displacement in each of the print units, and controls a register adjustment mechanism provided in each of the print units based on the amount of register displacement to correct a register of the print. | 2013-07-18 |
20130184135 | METHOD FOR FOLDING BLANKS OF CORRUGATED BOARD FOR THE PRODUCTION OF FOLDING BOXES, AND APPARATUS FOR FOLDING THE CORRUGATED BOARD BLANKS - A method and system for folding blanks of corrugated board for the production of folding boxes. The blanks are formed with fold-line structuring such as grooves, scores, perforations or the like aligned at least approximately parallel to the course of the corrugations of the corrugated board and possibly also at right angles thereto. The board can be folded or bent along the fold-line structuring. In the region of at least some of the grooves, scores, perforations or the like aligned at least approximately parallel to the course of the corrugations of the corrugated board along which folding is carried out, a liquid is introduced before the folding operation, as a result of which the corrugated board in the region of the fold-line structuring is made flexible. | 2013-07-18 |
20130184136 | Method of Making and Using EVOH Blends Providing Improved Oxygen Resistance - The presently disclosed subject matter is directed to methods of making and using films that serve as barriers to atmospheric oxygen. More particularly, the presently disclosed subject matter pertains to methods of making and using films wherein at least one layer of the film contains a blend of primary and secondary barrier components. The primary barrier component is present in the layer in an amount of from about 65 to 95 weight percent, based on the blend weight, and comprises ethylene vinyl alcohol copolymer having an ethylene unit content ranging from 21 to 30 mol %. The secondary barrier component is present in the layer in an amount of from about 5 to 55 weight percent, based on blend weight, and comprises ethylene vinyl alcohol copolymer having an ethylene unit content ranging from 41 to 50 mol %. | 2013-07-18 |
20130184137 | METHOD AND APPARATUS FOR MANUFACTURING DISPOSABLE WORN ARTICLE - A method for manufacturing a disposable worn article, including: severing a continuous web W along a cut-off line L | 2013-07-18 |
20130184138 | METHOD AND APPARATUS FOR FORMING FAN-FOLDED WEB OF LABELS WITH IMPROVED REGISTRATION - An off line apparatus for converting a rolled web into a fan-fold web and method of fan folding a web is described. The apparatus has a creasing station capable of receiving the web at a feed rate. The creasing station has a first die roller, wherein the first die roller comprises a first blade and a first cushion, and a second die roller. A coupling mechanism synchronizes rotation of the rollers such that the first blade engages the second cushion and the second blade engages the first cushion during one each rotation. A reader determines the location of a gap between the labels. A controller receives the location of the gap from said reader and communication with a drive mechanism to adjust the rotation rate such that the first blade and the second cushion engage. | 2013-07-18 |
20130184139 | FREELY MOVABLE TUCKER APPARATUS AND METHOD - A movable tucker apparatus and method include a tucker element having a tip and base at opposite ends thereof, a tucker spring and a tucker positioning lug configured for operative mounting within the slot in a folding roll. The lug is operatively affixed to the roll within the slot and extends at least partly across a width of the slot. The tucker element includes a relief for operative receipt therein of the lug. The tucker element, lug and spring are operatively connected to allow the tucker element to move in and out within the slot, and the tip of the tucker to move circumferentially with respect to the slot when the tucker element is operatively mounted in the slot and the tucker positioning lug operatively disposed within the relief in the tucker element. | 2013-07-18 |
20130184140 | CENTRIFUGE - A centrifuge includes a vacuum pump machine configured of an auxiliary vacuum pump and an oil diffusion pump for exhausting gas inside a rotary chamber to outside, in which a rotor rotates at high speed. In the centrifuge, a thermistor for detecting a temperature of oil and an oil surface inside a boiler of the oil diffusion pump is provided inside the boiler, and power of a heater is adjusted with the temperature detected by the thermistor, so that a degree of vacuum inside the rotary chamber is stably reduced from atmospheric pressure to a high vacuum state. Besides, when the heater does not heat, a current is carried through the thermistor for self-heating, and it is determined from variation in a resistance value whether the oil exists or not at a position at which the thermistor | 2013-07-18 |
20130184141 | PROCESS FOR PRODUCING CERAMIC FIBER-REINFORCED COMPOSITE MATERIAL AND CERAMIC FIBER-REINFORCED COMPOSITE MATERIAL - To obtain a ceramic fiber-reinforced composite material, by melt-infiltrating a composite material substrate obtained by forming ceramic fibers into a composite with a matrix formed of an inorganic substance, with an alloy having a composition that is constituted by a disilicate of at least one or more transition metal among transition metals that belong to Group 3A, Group 4A or Group 5A of the Periodic Table and silicon as the remainder, and having the silicon content ratio of 66.7 at % or more. | 2013-07-18 |
20130184142 | METHOD OF TREATING A PRECERAMIC MATERIAL - A method of treating a preceramic material includes modifying a moiety Si—O—R of a polycarbosilane material with at least one metal (M), where Si is silicon, O is oxygen and R includes an alkyl or aryl moiety, by reaction to substitute R with M to produce a preceramic polycarbosilane or polycarbosiloxane material that includes a moiety Si—O-M. | 2013-07-18 |
20130184143 | Graphene-Reinforced Ceramic Composites and Uses Therefor - The disclosure provides novel graphene-reinforced ceramic composites and methods for making such composite materials. | 2013-07-18 |
20130184144 | METHODS OF MAKING NON-COVALENTLY BONDED CARBON-TITANIA NANOCOMPOSITE THIN FILMS AND APPLICATIONS OF THE SAME - In one aspect, a method of making non-covalently bonded carbon-titania nanocomposite thin films includes: forming a carbon-based ink; forming a titania (TiO | 2013-07-18 |
20130184145 | POROUS BODY AND PRODUCTION METHOD THEREFOR - The present invention provides a porous material which has continuous pores and comprises a polymethyl methacrylate as a main component, wherein the continuous pores have a diameter of 0.001 μm to 500 μm and at least one surface of the porous material has a porosity of 10% to 80%; a separation membrane composed of the same; an adsorbent composed of the same; and a method production of the same. A porous material whose surface porosity and pore diameter are each controlled in a specific range can be obtained. The porous material has a fine and uniform porous structure in which the pore diameter can be controlled in the order of nanometers to micrometers; therefore, it can be advantageously used as a separation membrane such as a blood component separation membrane of an artificial kidney or the like or as an adsorbent. | 2013-07-18 |
20130184146 | METHOD FOR TUNING SURFACE STRUCTURE OF METALLIC NANO-CATALYST AND PREPARATION METHOD THEREOF - The present disclosure relates to a surface structure control and preparation process for a metal nanocatalyst involving a metal nanocatalyst. The present disclosure provides a surface structure control and continuous preparation system for a metal nanocatalyst, a metal nanocatalyst having an open surface structure and high surface energy, and a surface structure control and a preparation process thereof. The system is provided with a nucleation electrolytic cell, a distribution valve, at least two growth electrolytic cells, with two ends of the distribution valve being connected to an output port of the nucleation electrolytic cell and to input port of all the growth electrolytic cells, respectively. The metal nanocatalyst having an open surface structure is a single metal nanoscale crystal and has a high density of terrace atoms or active sites on the surface thereof. The precursor reaction solution is injected into the nucleation electrolytic cell, and a nucleation programmed potential is applied to one pair of electrodes in the nucleation electrolytic cell to obtain a nucleation reaction solution having the metal crystal nucleus formed, which is conveyed to the growth electrolytic cell through the distribution valve, a growth programmed potential is applied to one pair of electrodes in the growth electrolytic cell to obtain a metal nanoscale crystal having an open surface structure; controlling the growth time to obtain a reaction solution, and collecting a product by centrifugation. | 2013-07-18 |
20130184147 | ZEOLITE OR AN ANALOGOUS MATERIAL THEREOF INCLUDING MESOPORES ARRANGED REGULARLY OR IRREGULARLY, AND PREPARATION METHOD FOR SAME - The present invention relates to a novel zeolite or zeolite-like material synthesized using a zeolite synthesis composition comprising a specifically designed organic surfactant, wherein the zeolite or zeolite-like material comprises a crystalline framework having a thickness corresponding to up to 10 single unit cells along at least one axis, and 2-50 nm mesopores formed by organic assembly of the crystalline framework are regularly or irregularly arranged in the zeolite or zeolite-like material. In addition, the present invention presents a micro-mesoporous molecular sieve material activated or functionalized by dealumination, ion exchange or other post-treatment processes, and a method of using the molecular sieve material as a catalyst. The disclosed novel materials have a significantly increased outer surface area and pore volume due to a combination of micropores and mesopores, and thus show an increased diffusion of molecules therein. Accordingly, these materials will exhibit significantly increased activities compared to conventional zeolite catalysts and ion exchange resins. | 2013-07-18 |
20130184148 | ETHANOL PRODUCTION FROM ACETIC ACID UTILIZING A COBALT CATALYST - A process for the selective production of ethanol by vapor phase reaction of acetic acid over a hydrogenating catalyst composition to form ethanol is disclosed and claimed. In an embodiment of this invention reaction of acetic acid and hydrogen over either cobalt and palladium supported on graphite or cobalt and platinum supported on silica selectively produces ethanol in a vapor phase at a temperature of about 250° C. | 2013-07-18 |
20130184149 | Adsorbing Agent Containing Titanium and Iron Compounds - A composition containing titanium and iron compounds, in particular decomposition residue that accumulates as a production residue after the sulphate process during the production of titanium dioxide, is used as an adsorbing agent for inorganic and organic compounds, for example compounds containing phosphorus, arsenic, antimony, sulphur, selenium, tellurium, the cyano group or heavy metal. Toxic substances and pollutants may be removed from a fluid using the adsorbing agent. | 2013-07-18 |
20130184150 | COMPOSITIONS AND METHODS FOR INCREASING BIOMASS, IRON CONCENTRATION, AND TOLERANCE TO PATHOGENS IN PLANTS - Methods for producing greater biomass in a plant, increasing the drought tolerance of a plant, producing a decreased lignin concentration in a plant, producing a greater iron concentration in a plant, or inhibiting fungal infection in a plant comprise administering | 2013-07-18 |
20130184151 | MODULATION OF PLANT BIOLOGY - A method of effecting at least one biological process in a plant is disclosed. The method comprises contacting a part of a seed, a plant, or the locus thereof with a mixture comprising an agriculturally acceptable mixture of (i) complex polymeric polyhydroxy acids and (ii) a phytotoxic amount of one or more alkali (earth) salts and/or a synergistic amount of at least one source of an agriculturally acceptable transition metal ions. | 2013-07-18 |
20130184152 | Active compounds combinations Comprising Prothioconazole and fluxapyroxad - The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) prothioconazole and (B) fluxapyroxad and optionally (C) a further fungicidally active compound. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops (e.g. cereals such as wheat, barley, rye, oats, millet and triticale; soya beans; rice; com/maize; oil seed rape including canola; beans, peas, peanuts; sugar beet, fodder beet, beetroot; potatoes; cotton), and to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed. | 2013-07-18 |
20130184153 | Composition containing a pyripyropene insecticide and a base - The present invention relates to a composition comprising a pyripyropene pesticide of the formula (I) or (II) as defined below | 2013-07-18 |
20130184154 | Pseudozyma Aphids As A Biocontrol Agent Against Various Plant Pathogens - Biocontrol agents are provided, which protect plant and plant material from pests and pathogens, and promote the growth of plants. Also provided are compositions comprising the same, methods for protecting plant and plant material and promoting growth in plants, and uses of said biocontrol agent in the preparation of a pesticidal composition and a growth-promoting composition. | 2013-07-18 |
20130184155 | Herbicidal Benzoxazinones - The present invention provides benzoxazinones of formula I | 2013-07-18 |
20130184156 | HERBICIDAL COMPOSITIONS CONTAINING BENTAZON AND ALS INHIBITOR AND ACCASE INHIBITOR - Herbicidal compositions comprising (a) bentazon-sodium and (b) an ALS inhibitor and (c) an ACCase inhibitor controls susceptible and resistant weeds in crops, e.g., rice, wheat, barley, oats, rye, sorghum, corn/maize, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards and IVM, but also additionally in ALS and ACC'ase tolerant crops. | 2013-07-18 |
20130184157 | Improved Processes for the Control of Undesired Vegetative Growth In Crops - Disclosed are compositions comprising a microencapsulated triallate compound, and an improved process for the control of undesired vegetative growth in and among desired vegetative growth, especially cereal crops, the process comprising the steps of: providing an effective amount of a treatment composition to the treated crop. | 2013-07-18 |
20130184158 | Superconducting Magnet System for Nuclear Magnetic Resonance with High Magnetic Field and High Degree of Homogeneity of Magnetic Field - A superconducting magnet system for nuclear magnetic resonance with a high magnetic field and a high degree of homogeneity of magnetic field is provided. The system comprises a main coil and a magnetic field homogeneity compensating coil having a combination of a forward current and a reverse current, and is composed of 24 superconducting coils formed by winding NbTi/Cu low-temperature superconducting wires. The system can produce a magnetic field of 9.4 T within a room-temperature space of 800 mm and can obtain a degree of non-homogeneity of magnetic field less than 0.1 ppm within a spherical volume of 300 mm. The system is equipped with a superconducting magnet inside, and a low-temperature vessel for liquid helium provides a low-temperature environment of 4K which is required for the normal operation of the superconducting magnet. A ferro-magnetic shielding system enables the system to have a good electromagnetic compatibility. | 2013-07-18 |
20130184159 | CRYOGENIC POWER CONTROL - An apparatus | 2013-07-18 |
20130184160 | NUCLEOTIDES AND APTAMERS CONTAINING BORONIC ACID GROUPS HAVING BIASED BINDING TO GLYCOSYLATED PROTEINS, AND USES THEREOF - The present disclosure encompasses oligonucleotide aptamers selectively binding a target glycosylated polypeptide or protein, and having biased affinity for the glycan through a boronic acid linked to a nucleosidic base of a nucleotide(s). The disclosure further encompasses methods for isolating an aptamer(s) selectively binding a target glycosylated polypeptide, where, from a population of randomized oligonucleotides that have at least one nucleotide having a boronic acid label linked to a base, is selected a first subpopulation of aptamers binding to the target glycosylated polypeptide or protein. This subpopulation is then amplified without using boronic acid-modified TTP, and amplification products not binding to a target glycosylated polypeptide or protein are selected. The second subpopulation of aptamers is then amplified using boronic acid-modified TTP to provide a population of boronic acid-modified aptamers capable of selectively binding to a glycosylation site of a target polypeptide or protein. Other aspects of the disclosure encompass methods for the use of the modified aptamers to detect glycosylated species of a polypeptide or protein. | 2013-07-18 |
20130184161 | Methods and Systems for Medical Sequencing Analysis - Disclosed are methods of identifying elements associated with a trait, such as a disease. The methods can comprise, for example, identifying the association of a relevant element (such as a genetic variant) with a relevant component phenotype (such as a disease symptom) of the trait, wherein the association of the relevant element with the relevant component phenotype identifies the relevant element as an element associated with the trait, wherein the relevant component phenotype is a component phenotype having a threshold value of severity, age of onset, specificity to the trait or disease, or a combination, wherein the relevant element is an element having a threshold value of importance of the element to homeostasis relevant to the trait, intensity of the perturbation of the element, duration of the effect of the element, or a combination. The disclosed methods are based on a model of how elements affect complex diseases. The disclosed model is based on the existence of significant genetic and environmental heterogeneity in complex diseases. Thus, the specific combinations of genetic and environmental elements that cause disease vary widely among the affected individuals in a cohort. The disclosed model is an effective, general experimental design and analysis approach for the identification of causal variants in common, complex diseases by medical sequencing. Also disclosed herein are methods of identifying an inherited trait in a subject. The disclosed methods compare a reference sequence from a subject to a library of sequences that contain each mutation. For a given mutation, a normal sequence read aligns best to the normal library sequence. A read having the mutation aligns best to the mutant library sequence. The disclosed model and the disclosed methods based on the model can be used to generate valuable and useful information. | 2013-07-18 |
20130184162 | SYSTEM AND APPARATUS FOR SEQUENTIAL PROCESSING OF ANALYTES - An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process. | 2013-07-18 |
20130184163 | METHOD FOR IDENTIFYING COMPOUNDS - The present invention relates to a method for identifying compounds comprising the steps of: (a) providing a set of compounds; (b) optionally selecting a sub-set from the set of compounds based on one or more specific compound properties; (c) generating a 3D structure of each of the compounds provided and/or selected in step (a) or (b); (d) encoding each 3D structure; (e) providing at least one known compound having at least one desired property and/or providing a target molecule; (f) encoding the 3D structure of (each of) the known compound(s) provided in step (e) and/or the active site of the target molecule provided in step (e); (g) comparing said encoded 3D structure(s) of step (d) with the encoded 3D structure(s) of step (f); and (h) selecting all compounds falling within a specified similarity range. | 2013-07-18 |
20130184164 | DNA Chip for Genotyping of Human Papilloma Virus, Kit Having Same, and Method for Genotyping - Disclosed is a DNA chip (or DNA microarray) on which probes complementarily binding to the nucleic acids of 44 types of HPV, which is the main cause of cervical cancer and the most common cause of sexually transmitted diseases, are spotted, a genotyping kit including same and a genotyping method using same. In accordance with the present disclosure, all the 44 types of HPV invading the genitalia can be detected and coinfection by more than one type of HPV can be diagnosed accurately. The sensitivity and specificity of HPV genotyping is close to 100% and a number of samples can be tested quickly. The present disclosure is very useful in predicting cervical cancer and precancerous lesions. | 2013-07-18 |
20130184165 | GENOTYPING BY NEXT-GENERATION SEQUENCING - Provided herein is technology relating to genotyping and particularly, but not exclusively, to methods for genotyping one or more organisms by genome sequencing. | 2013-07-18 |
20130184166 | METHOD FOR THE IDENTIFICATION OF THE CLONAL SOURCE OF A RESTRICTION FRAGMENT - The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end. The amplified adapter-ligated restriction fragments are, at least partly, sequenced using high throughput sequencing methods and the sequence parts of the restriction fragments together with the sample-specific identifiers serve as molecular markers. | 2013-07-18 |
20130184167 | GENETIC MARKERS FOR THE PROGNOSIS OF MULTIPLE SCLEROSIS - The present invention relates to a series of genes the expression of which is altered in subjects suffering multiple sclerosis with respect to healthy subjects or in subjects suffering multiple sclerosis with a good prognosis with respect to subjects suffering multiple sclerosis with a bad prognosis. A subset formed by 13 genes and two clinical variables which allows predicting the progress of a patient with a high reliability has been validated from an initial set of genes which showed said differential expression. From said expression values, the invention provides methods for predicting the progress of a patient diagnosed with multiple sclerosis from tables of conditional probability between the expression levels of a determined gene or group of genes and the probability that the patient has a good or bad prognosis of the disease. | 2013-07-18 |
20130184168 | IMMUNOREACTIVE FRANCISELLA TULARENSIS ANTIGENS - The present invention relates to immunoreactive | 2013-07-18 |
20130184169 | METHODS FOR ASSESSING RNA PATTERNS - Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs. | 2013-07-18 |
20130184170 | OLIGONUCLEOTIDE AMPLIFICATION PRIMERS FOR TARGETING ONCOGENIC HPV - The present invention relates generally to the field of diagnostic and detection assays. More particularly, the present invention provides methods and reagents including biochips for detecting the presence of, or distinguishing between, one or more analytes in a sample. | 2013-07-18 |
20130184171 | MULTIPLEXED AMPLIFICATION OF SHORT NUCLEIC ACIDS - The present teachings provide methods, compositions, and kits for reverse transcribing and amplifying small nucleic acids such as micro RNAs. High levels of multiplexing are provided by the use of a zip-coded stem-loop reverse transcription primer, along with a PCR-based pre-amplification reaction that comprises a zip-coded forward primer. Detector probes in downstream decoding PCRs can take advantage of the zip-code introduced by the stem-loop reverse transcription primer. In some embodiments, further amplification is achieved by cycling the reverse transcription reaction. The present teachings also provide compositions and kits useful for performing the reverse transcription and amplification reactions described herein. | 2013-07-18 |
20130184172 | Bladder Cancer Detection Composition, Kit and Associated Methods - Compositions, kits, and methods for the diagnosis, prognosis, and monitoring of bladder cancer in a subject are provided by detecting in a urine sample a combination of biomarkers. In one embodiment of the invention, a nine-biomarker panel consisting of IL-8, MMP9, SDC1, CCL18, SERPINE1, CD44, VEGF-A, CA9, and ANG may be detected. In another embodiment of the invention, a three-biomarker panel consisting of CCL18, CD44, and VEGF-A may be detected. In yet another embodiment of the invention, a nine-biomarker panel consisting of CA9, CCL18, MMP12, TMEM45A, MMP9, SEMA3D, ERBB2, CRH, and MXRA8 may be detected. | 2013-07-18 |
20130184173 | BIOMARKERS FOR MULTIPLE SCLEROSIS - Biomarkers that can be used for the diagnosis and prognosis of multiple sclerosis in pediatric patients presenting with clinically isolated syndrome or acquired demyelination syndrome are described. | 2013-07-18 |
20130184175 | MICRORNAS DIFFERENTIALLY EXPRESSED IN CERVICAL CANCER AND USES THEREOF - The present invention concerns methods and compositions for identifying a miRNA profile for a particular condition, such as cervical disease, and using the profile in assessing the condition of a patient. | 2013-07-18 |
20130184176 | Methods and Compositions for Rapid Multiplex Amplification of STR Loci - Provided are methods for multiplex polymerase chain reaction (PCR) amplification of short tandem repeat (STR) loci that can be used to rapidly generate a highly specific STR profile from target nucleic acids. The resulting STR profiles are useful for human identification purposes in law enforcement, homeland security, military, intelligence, and paternity testing applications. | 2013-07-18 |
20130184177 | BACTERIAL SURFACE DISPLAY AND SCREENING OF THIOETHER-BRIDGE-CONTAINING PEPTIDES - The invention relates to bacterial cell surface display of post-translationally modified heterologous proteins. Provided is an isolated nucleic acid construct encoding a proteinaceous substance comprising, from the N-terminus to the C-terminus, at least (a) an N-terminal a lantibiotic leader sequence; (b) an amino acid sequence of interest to be post-translationally modified to a dehydroresidue- or thioether-bridge containing polypeptide; (c) a hydrophilic cell-wall spanning domain; (d) a sortase recognition motif; (e) a hydrophobic membrane spanning domain and (f) a C-terminal charged membrane anchoring domain. Also provided is a Gram-positive host cell expressing the construct, as well as a library of host cells. | 2013-07-18 |
20130184178 | Methods of Detecting Autoimmune or Immune-Related Diseases or Conditions - The disclosure provides methods of using phagocytic cells alone or in combination with non-phagocytic cells in the diagnosis, prognosis, or monitoring of autoimmune or immune-related diseases or conditions. The disclosure also provides methods of using phagocytic cells alone or in combination with nonphagocytic cells to identify markers of autoimmune or immune-related diseases or conditions. | 2013-07-18 |
20130184179 | SMALL MOLECULE ARRAYS AND METHODS FOR MAKING AND USING THEM - In alternative embodiments, the invention provides products of manufacture, such as arrays or microarrays, comprising cells and compounds such as small molecules or drugs for e.g., drug screening or toxicity testing. | 2013-07-18 |
20130184180 | CHARACTERIZATION OF N-GLYCANS USING EXOGLYCOSIDASES - The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially. | 2013-07-18 |
20130184181 | ANALYTE DETERMINATION UTILIZING MASS TAGGING REAGENTS COMPRISING A NON-ENCODED DETECTABLE LABEL - This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination and/or quantification by mass spectrometry using compounds comprising a reporter moiety and a non-encoded detectable label. The compounds can be used in sets for the analysis of mixtures of labeled analytes. | 2013-07-18 |
20130184182 | BIO CHIP - There is provided a bio-chip including a first substrate including a plurality of micro-pillars protruded from one surface thereof to a predetermined height and having a biomaterial adhered to protruded surfaces of the plurality of micro-pillars, wherein the first substrate is formed of a resin composition including 100 parts by weight of polystyrene and 5 to 30 parts by weight of maleic anhydride. | 2013-07-18 |
20130184183 | RECOMBINANT BACTERIOPHAGE AND METHODS FOR THEIR USE - Recombinant P4 bacteriophage containing modified tail fibers having a base plate attachment region (BPAR) from a P2 bacteriophage gene H product and a heterologous receptor binding domain (RBD) are disclosed. Methods for the use of the recombinant P4 bacteriophage, such as to detect the presence of a target bacterium in a sample, are also described. | 2013-07-18 |
20130184184 | Methods and/or Use of Oligonucleotide Conjugates Having Varied Degrees of Labeling for Assays and Detections - The present disclosure is directed to methods and/or uses of oligonucleotide conjugates having varied degrees of labeling for assays and detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein. | 2013-07-18 |
20130184185 | METHODS FOR INCREASING THE DIVERSITY OF MONOCLONAL ANTIBODIES PRODUCED AGAINST AN ANTIGEN - The present invention relates to methods for increasing the diversity of monoclonal antibodies produced against an antigen. The methods of the invention utilize immunization of a murine host defective in one or more enzymes involved in a post-translational modification of a polypeptide or a modification of a lipid, wherein said modification is exposed on a cell surface. The invention also relates to monoclonal antibodies produced by these methods and which are not produced when a normal mouse is immunized with the same antigen. The invention further relates to compositions comprising these monoclonal antibodies, as well as to such monoclonal antibodies bound or conjugated to a toxin, a detectable marker or to a solid support. | 2013-07-18 |
20130184186 | SYSTEMS AND METHODS FOR THE DETECTION OF BIOMARKERS - Systems and methods for the detection of biomarkers. In at least one embodiment of a microarray system of the present disclosure, the microarray system comprises a microarray product comprising at least 100 diagnostic markers/cm | 2013-07-18 |
20130184187 | SYSTEMS AND METHODS FOR BIOMARKER ANALYSIS - Systems and methods of biomarker analysis. In at least one embodiment of a system for determining the therapeutic potential of a therapeutic compound the present disclosure, the system comprises a detection platform, a computer database capable of receiving a plurality of binding characteristics, a processor operably coupled to the computer database and the detection platform. In at least one embodiment, the processor has and executes a software program operational to determine a binding characteristic of the detection agent and a stabilized diagnostic agent in each of the plurality of detection sites, compare the binding characteristic among each of the plurality of detection sites, wherein the comparison of binding characteristics is capable of determining the stabilizing agent with the greatest effect on the binding characteristic between the detection agent and the diagnostic agent, generate a binding record using the compared binding characteristics, and deliver the binding record to a recipient. | 2013-07-18 |
20130184188 | Integrated Test Device for Optical Detection of Microarrays - This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to testing devices having an optically readable microspot array and/or an electrochemical detector and to methods of performing microspot arrays and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care. | 2013-07-18 |
20130184189 | Star Polymer Lubricating Composition - The invention provides a lubricating composition containing (a) a polymer derived from greater than 50 wt % or more of a non-diene monomer, wherein the polymer has a weight average molecular weight of about 2000 to about 200,000, and wherein the polymer has a shear stability index of about 0 to about 25; (b) a phosphorus-containing acid, salt, or ester; (c) an extreme pressure agent, other than a phosphorus-containing acid, salt, or ester; and (d) an oil of lubricating viscosity. The invention further provides a method for lubricating a mechanical device with the lubricating composition. | 2013-07-18 |
20130184190 | ANTIOXIDANT COMPOSITION AND LUBRICATING OIL COMPOSITION CONTAINING SAME - Provided is an antioxidant composition, including: a compound (A) represented by the following general formula (1); and an amine-based antioxidant (B) and/or a phenol-based antioxidant (C) other than the compound (A): | 2013-07-18 |
20130184191 | GEAR OIL COMPOSITIONS - A novel lubricant composition is disclosed. In one embodiment the lubricant composition comprises in admixture: a first base stock component comprising one or more base stocks each having a viscosity of at least 40 cSt, Kv100° C. and a molecular weight distribution (MWD) as a function of viscosity at least 10 percent less than algorithm: MWD=0.2223+1.0232*log (Kv at 100° C. in cSt); and a second base stock component comprising at least one Poly-Alpha-Olefin (PAO) base stock and at least one Group III base stock, each having a viscosity less than 110 cSt, Kv100° C. | 2013-07-18 |
20130184192 | CONCENTRATED CLEANING COMPOSITIONS AND THEIR USE - The present disclosure relates to a concentrated acidic floor cleaner and methods of using it to clean floors. The concentrated acidic floor cleaner can be diluted to form a use solution that is effective at removing polymerized grease, including animal and vegetable fats and non-trans fats, and other soils from floors. The use solution is especially useful for cleaning floors in commercial kitchens of full service and quick service restaurants and is effective on a variety of floors, including quarry tile. | 2013-07-18 |
20130184193 | COTTON-GENTLE HYPOCHLORITE BLEACH - Methodologies and equipment for using a hypochlorite solution to remove menstrual fluid, underarm perspiration or other hard-to-remove stains from soft fabric articles with reduced damage to the fabric articles when compared with popular chlorine bleaches. The soft fabric articles preferably are in white, although the present invention can also be applied to articles in other colors. In one embodiment, the weight concentration ratio of the alkali metal hydroxide over the hypchlorite salt in the hypochlorite solution is no less than 1:12.5. The hypochlorite solution may contain at least 0.2% by weight of sodium hydroxide and/or have a pH of at least 11.8. | 2013-07-18 |
20130184194 | FABRIC TREATMENT COMPOSITIONS COMPRISING TARGETED BENEFIT AGENTS - The invention provides a benefit agent delivery particle comprising hydroxylpropyl cellulose. The benefit agent delivery particle may further comprise a non-polysaccharide polymer, preferably an aminoplast polymer. The benefit agent delivery particle may comprise a perfume. The invention also provides a process for the manufacture of the particles in which perfume oil is encapsulated using emulsion polymerization to form core-shell particles, (in the alternative the perfume may be adsorbed later) and, a further polymer layer is formed on the outer surface of the core shell-particles in the presence of the delivery aid. | 2013-07-18 |
20130184195 | ACIDIC LAUNDRY DETERGENT COMPOSITIONS - An acidic laundry detergent composition comprising less than about 20% of a surfactant system comprising surfactants selected from the group consisting of anionic surfactants, nonionic surfactants, cationic surfactants and mixtures thereof, wherein the surfactant system has a Hydrophilic Index of greater than or equal to about 9.00 and an organic acidulant at a level such that the ratio of surfactant system to organic acidulant is less or equal to about 3.0 and an alkaline neutralizer added in an amount necessary to raise the neat pH of the detergent composition above or equal to about 2.5 but no higher than or equal to about 3.0. | 2013-07-18 |
20130184196 | Cleaning Compositions - An aqueous composition is disclosed, comprising at least one strain of Class 1 | 2013-07-18 |
20130184197 | FUNCTIONAL SHEET FOR DELIVERING LAUNDRY ACTIVES IN LOW-TEMPERATURE WATER - Disclosed is a washing method using a functional sheet, the method comprising; adding the functional sheet to a washing medium at a rinsing step of washing process; wherein the washing medium contains a rinsing water of 0° C. to 30° C. and a second substrate; wherein the functional sheet comprises; a first substrate; and an active ingredient applied on or impregnated into the first substrate, wherein the active ingredient has at least one material selected from the group consisting of a softener, an aromatic agent, an antistatic agent, a stabilizer, a colorant, a preservative, an optical brightener, and a bleaching agent; wherein the active ingredient, which is released from the first substrate and dispersed into the rinsing water, is to be physically or chemically adsorbed onto the second substrate in the rinsing water, and remains on the second substrate after removal of the rinsing water. | 2013-07-18 |
20130184198 | Pulmonary Surfactant Formulations - Synthetic pulmonary surfactant compositions comprising dipalmitoyl phosphatidylcholine, phosphatidylglycerol, and essentially neutral lipid, and having essentially no 1-palmitoyl 2-oleoyl phosphatidylglycerol and essentially no palmitic acid are provided. Methods for treating respiratory disease are also provided comprising administering a therapeutically effective amount of a synthetic pulmonary surfactant comprising dipalmitoyl phosphatidylcholine, phosphatidylglycerol, and essentially neutral lipid, and having essentially no 1-palmitoyl 2-oleoyl phosphatidylglycerol and essentially no palmitic acid. | 2013-07-18 |
20130184199 | INSULIN RECEPTOR INDUCED ELASTIN PRODUCTION - Compositions and methods for modulating the deposition of elastin by administering compositions including insulin receptor agonists are described herein. | 2013-07-18 |
20130184200 | Immunogenic Polypeptides and Monoclonal Antibodies - Provided herein are compositions and methods for eliciting an immune response against | 2013-07-18 |
20130184201 | Cyclodepsipeptides with Antineoplastic Activity and Methods of Using to Inhibit Cancer and Microbial Growth - The present invention is directed to cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity, preferably Kitastatin 1. The present invention is further directed to methods of inhibiting cancer cell growth and/or microbial growth in a host inflicted therewith by administering cyclodepsipeptide compounds to the inflicted host. | 2013-07-18 |
20130184202 | Peptide Inhibitors and Methods of Use Thereof - Peptides and methods of use thereof are provided. | 2013-07-18 |
20130184203 | GLP-1 RECEPTOR AGONIST COMPOUNDS HAVING STABILIZED REGIONS - The disclosure provides GLP-1 receptor agonist compounds having stabilized regions corresponding to alpha-helical regions of the natural peptide compounds. The disclosure also provides benzamide-containing exendin-4 analogs and alkene-constrained exendin-4 analogs, both of which have stabilized regions corresponding to alpha-helical regions of exendin-4. | 2013-07-18 |
20130184204 | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions - The present invention relates to substituted quinazolines of formula (I): | 2013-07-18 |
20130184205 | ANTITUMOR COMBINATIONS CONTAINING A VEGF-INHIBITING AGENT AND 5FU OR A DERIVATIVE THEREOF - This invention relates to antitumor combinations comprising a VEGF inhibitor combined with 5-fluorouracil or with a 5-fluoropyrimidine derivative that are therapeutically useful in the treatment of neoplastic diseases, and pharmaceutical compositions comprising such combinations. | 2013-07-18 |
20130184206 | Selective androgen receptor modulators (SARMs) and uses thereof - Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions. | 2013-07-18 |
20130184207 | LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME - A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed. | 2013-07-18 |
20130184208 | BMP Mutants with Decreased Susceptibility to Noggin - The present invention provides modified, highly potent bone morphogenetic proteins. In particular, the present invention relates to the observation that BMP-6 and BMP-9 are less susceptible to inhibition by Noggin that are other members of the BMP subfamily of proteins. The present invention features chimeric bone morphogenetic proteins in which the middle portion of BMP-6 or BMP-9 replaces the middle portion of another BMP subfamily protein to cause resistance to inhibition by Noggin or other Noggin-like antagonists. Other embodiments of modified BMPs, compositions and methods of use are also included. | 2013-07-18 |
20130184209 | PROTEIN STABILIZATION FORMULATIONS - The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants. | 2013-07-18 |
20130184210 | VARIANTS DERIVED FROM ACTRIIB AND USES THEREFOR - In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand. | 2013-07-18 |
20130184211 | INHIBITING BINDING OF FGF23 TO THE BINARY FGFR-KLOTHO COMPLEX FOR THE TREATMENT OF HYPOPHOSPHATEMIA - The present invention is directed to a method of treating hypophosphatemia in a subject. This method involves selecting a subject with hypophosphatemia associated with elevated or normal FGF23 and administering to the selected subject an inhibitor of FGF23-Klotho-FGF receptor complex formation under conditions effective to treat the hypophosphatemia. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate compounds. The FGF23, the FGFR-Klotho complex, and the candidate compounds are combined under conditions effective for the FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves. This method also involves identifying the candidate compounds, which prevent formation of the complex as being potentially suitable in treating hypophosphatemic conditions associated with elevated or normal FGF23. A method of screening the specificity of compounds which prevent formation of the FGF23-Klotho-FGFR complex is also disclosed. | 2013-07-18 |
20130184212 | FIBRONECTIN BASED SCAFFOLD PROTEINS HAVING IMPROVED STABILITY - The present application provides fibronectin based scaffold proteins associated with improved stability. The application also relates to stable formulations of fibronectin based scaffold proteins and the use thereof in diagnostic, research and therapeutic applications. The application further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising such polynucleotides. | 2013-07-18 |
20130184213 | Amylin and Amylin Agonists for Treating Psychiatric Diseases and Disorders - Methods and compositions for treating psychiatric diseases and disorders are disclosed. The methods provided generally involve the administration of an amylin or an amylin agonist to a subject in order to treat psychiatric diseases and disorders, and conditions associated with psychiatric diseases and disorders. | 2013-07-18 |
20130184214 | PHARMACEUTICAL COMPOSITIONS AND METHODS - Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof. Also provided are methods of reducing cell proliferation in a subject comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof. | 2013-07-18 |
20130184215 | PEPTIDE HAVING A VASCULARIZATION-SUPPRESSING ACTIVITY AND A USE THEREFOR - Provided are peptides having anti-angiogenic activity and a use thereof, and more particularly, to peptides for inhibiting angiogenesis, the peptides including amino acid sequence with potent anti-angiogenic activity, a composition for inhibiting angiogenesis, the composition including the peptides, a medicine for inhibiting angiogenesis, the medicine including the composition, and a method for inhibiting angiogenesis using the peptides. The peptides for inhibiting angiogenesis, the peptides including the amino acid sequence of the invention provides not only potent inhibitory activity on proliferation, migration and tube formation of vascular endothelial cells, but also potent in vivo anti-angiogenic activity and inhibitory activity on proliferation and migration of cancer cells. Therefore, the peptide for inhibiting angiogenesis can be efficaciously used as a treatment for various diseases including cancer with abnormal regulation of angiogenesis. | 2013-07-18 |
20130184216 | NOVEL ALBUMIN-FREE FACTOR VIII FORMULATIONS - A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8. Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8. In a further embodiment, the formulation can comprise: 300 mM to 500 mM NaCl; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; and a buffering agent. | 2013-07-18 |
20130184217 | TARGETING MICRORNAS FOR THE TREATMENT OF FIBROSIS - Provided herein are compositions and methods for the modulation of 'miR-214 for the treatment and/of prevention of fibrosis arid fibroproliferative conditions. | 2013-07-18 |
20130184218 | Targeted Osmotic Lysis of Cancer Cells - A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gated sodium channels (VGSCs) has been developed that uses a combined therapy of a drug that blocks sodium, potassium-adenosine triphosphatase (Na | 2013-07-18 |
20130184219 | EXTRACT AND PEPTIDES DERIVED FROM ORYZA SATIVA JAPONICA GROUP AND USES THEREOF - The invention relates to isolated peptides derived from | 2013-07-18 |
20130184220 | TREATMENT OF ABNORMAL OR EXCESSIVE SCARS - Methods and compositions comprising combinations and uses of a first anti-connexin agent and a second anti-connexin agent, for example, one or more anti-connexin polynucleotides and one or more anti-connexin peptides or peptidomimetics, are provided for the treatmen or prevention of abnormal or excessive scarring. | 2013-07-18 |
20130184221 | Kinase Inhibitors And Uses Thereof - The present invention relates to kinase inhibiting compositions and uses thereof. The invention further provides isolated kinase inhibiting peptides and uses thereof for inhibiting hyperplasia, for inhibiting the growth of neoplasms, and for inducing programmed cell death in a cell population. | 2013-07-18 |
20130184222 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE - Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here. | 2013-07-18 |
20130184223 | METHODS AND COMPOSITIONS RELATED TO MODULATING AUTOPHAGY - Disclosed are compositions and methods related to new targets for cancer treatment the modulation of autophagy. | 2013-07-18 |
20130184224 | METHODS FOR INHIBITING TUMOR GROWTH - The present invention provides a method for inhibiting androgen receptor (AR)-containing tumor cell growth in a subject in need thereof, comprising administrating to said subject a pharmaceutically effective amount of a damaged-DNA binding protein 2 (DDB2) and a pharmaceutically acceptable carrier. The present invention also provides a method for inhibiting androgen receptor (AR)-containing tumor cell growth in a subject in need thereof, comprising administrating to said subject a pharmaceutically effective amount of an expression vector comprising a gene encoding a damaged-DNA binding protein 2 (DDB2) and a pharmaceutically acceptable carrier. In a preferred embodiment, the expression vector is a plasmid vector. | 2013-07-18 |