28th week of 2017 patent applcation highlights part 9 |
Patent application number | Title | Published |
20170196961 | NOVEL METHOD FOR PREVENTING OR TREATING M TUBERCULOSIS INFECTION - The present invention is directed to methods of preventing reactivation of active and latent | 2017-07-13 |
20170196962 | STREPTOCOCCAL GlcNAc-LACKING GLYCOPOLYPEPTIDES, CELL WALL CARBOHYDRATES, STREPTOCOCCUS VACCINES, AND METHODS FOR MAKING AND USING THEM - In alternative embodiments, the invention provides vaccines, pharmaceutical compounds and formulations for diagnosing, preventing, treating or ameliorating Group A | 2017-07-13 |
20170196963 | DRUG TARGET AND CONSTRUCT FOR JAPANESE ENCEPHALITIS VIRUS INFECTION - A group of mosquito-borne flaviviruses that cause fatal encephalitis in humans is among the most important of all emerging human pathogens of global significance. This group includes Japanese encephalitis virus (JEV), West Nile virus, St. Louis encephalitis virus, and Murray Valley encephalitis virus. In the present disclosure, the first reverse genetics system has been developed for SA14-14-2, a live JE vaccine that is most commonly used in most JE-endemic areas, by constructing an infectious bacterial artificial chromosome that contains the full-length SA14-14-2 cDNA. Using this infectious SA 14-14-2 cDNA, combined with a mouse model for JEV infection, a key viral neurovirulence factor has been discovered that is a conserved single amino acid in the ij hairpin adjacent to the fusion loop of the viral E glycoprotein, which regulates viral infectivity into neurons within the central nervous system. | 2017-07-13 |
20170196964 | Novel Arenavirus Vaccine - The invention relates to compositions and methods for preventing or treating arenavirus related diseases and disorders through the administration to a subject in need thereof a live-attenuated virus (LAV), wherein the LAV is a codon deoptimized (CD) arenavirus. | 2017-07-13 |
20170196965 | Vaccine Containing Virus-Like Particles - The present invention provides a vaccine containing virus-like particles derived from virus particles having an envelope, in which a lipid-component content of the virus-like particles is reduced relative to a lipid-component content of the virus particles. | 2017-07-13 |
20170196966 | MICRONEEDLE COMPOSITIONS AND METHODS OF USING SAME - Described herein, are microneedle devices comprising a recombinant alphavirus replicon encoding an exogenous polypeptide, wherein the recombinant alphavirus replicon is coated onto or embedded into a plurality of microneedles. Also described herein are methods of preparing a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide. Also disclosed herein are methods of inducing an immune response in an individual comprising contacting the individual with a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide. | 2017-07-13 |
20170196967 | NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PATHOGENIC ANTIGEN - The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a pathogenic antigen or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the treatment of infectious diseases. The present invention further describes a method for increasing the expression of a peptide or protein comprising a pathogenic antigen or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal. | 2017-07-13 |
20170196968 | PROCESS FOR PRODUCING INFLUENZA VACCINE - A process for producing a split influenza virus preparation or subunit influenza preparation comprising the steps of: (i) providing a whole virus preparation; (ii) splitting the whole virus preparation in the presence of a first detergent; (iii) adding t-octylphenoxypolyethoxyethanol (TRITON X-100™) to the resulting split virus preparation; and (iv) filtering the split virus preparation. | 2017-07-13 |
20170196969 | VACCINATION IN NEWBORNS AND INFANTS - The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age of not more than 2 years, preferably of not more than 1 year, more preferably of not more than 9 months or even 6 months, wherein the treatment comprises vaccination of the newborn or infant and eliciting an immune response in said newborn or infant. The present invention is furthermore directed to kits and kits of parts comprising such a vaccine and/or its components and to methods applying such a vaccine or kit. | 2017-07-13 |
20170196970 | ADJUVANT FOR MUCOSAL VACCINE - An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response in a mucosal membrane. According to the present invention, an adjuvant for a mucosal vaccine containing a protein complex composed of hemagglutinin (HA) subcomponents HA1 and HA2, and mutant subcomponent HA3 of botulinum toxin is provided. | 2017-07-13 |
20170196971 | ANTIBODY GUIDED VACCINES AND METHODS OF USE FOR GENERATION OF RAPID MATURE IMMUNE RESPONSES - Adjuvant compositions, vaccines, constructs for preparing the adjuvant compositions and vaccines and methods of using the adjuvant compositions and vaccines to enhance immune responses in subjects are provided herein. In particular, a rapid antibody response to the vaccine including both IgG (in the circulation) and sIgA (mucosal secretory IgA) is elicited. The adjuvants and vaccines may be used for sub-cutaneous or mucosal administration enabling low cost, effective vaccination of subjects. A method of epitope mapping to rapidly identify antigenic epitopes is also provided. | 2017-07-13 |
20170196972 | DUAL ADJUVANT VACCINE COMPOSITIONS, PREPARATION AND USES - The present invention relates to vaccines comprising an effective amount of at least one antigen in a wa-ter-in-oil-in-water (WOW) emulsion and an additional adjuvant, and to the methods of preparation and uses thereof. | 2017-07-13 |
20170196973 | ONCOSTATIN M (OSM) ANTAGONISTS FOR PREVENTING CANCER METASTASIS AND IL-6 RELATED DISORDERS - A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an | 2017-07-13 |
20170196974 | LIQUID PHARMACEUTICAL COMPOSITION - The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an acetate buffering agent/system such as sodium acetate/acetic acid, and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary waste of the drug. | 2017-07-13 |
20170196975 | CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY - Conjugates of an anti-TNF antibody and one or more nonpeptidic water-soluble polymers are provided. Typically, the nonpeptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient. | 2017-07-13 |
20170196976 | PHOTODYNAMIC DIAGNOSIS, FORMULATIONS USABLE AS PHOTOSENSITIZERS FOR THIS PURPOSE, METHOD FOR THE PRODUCTION AND USE THEREOF - In the early detection of cancer, in particular bladder cancer, a photodynamic diagnosis uses, as a photosensitizer, a formulation that contains sodium hypericinate that is bonded to polyvinylpyrrolidone or complexed with polyvinylpyrrolidone. | 2017-07-13 |
20170196977 | METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY (PEPST) AND EXCITON-PLASMON ENHANCED PHOTOTHERAPY (EPEP) - The use of plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, the PEPST and EPEP agents and probes used therein, and pharmaceutical compositions using and/or containing the same. | 2017-07-13 |
20170196978 | Compositions with a Rheological Modifier to Reduce Dissolution Variability - The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided. | 2017-07-13 |
20170196979 | LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS - This invention provides for a compound of formula (I): | 2017-07-13 |
20170196980 | TRANSDERMAL ENHANCER - The present invention is related to a composition for enhancing topical and transdermal absorption comprising an alkali material having a pH in the range of about 9.0 to 14.0 and a water-soluble substance in an amount of at least 0.5 wt % more than an amount of the alkali material based on a total weight of the composition. The present invention is also related to a pharmaceutical composition comprising the composition, at least one therapeutically effective amount of a drug or an effective cosmetic ingredient, and a pharmaceutically acceptable carrier. The present invention is also related to a method for enhancing and delivering a drug through a body surface to minimize or eliminate the possibility of skin damage, irritation or sensitization while the above-described composition or the pharmaceutical composition is crossing patient's skin or mucosal tissue. | 2017-07-13 |
20170196981 | CARDIOVASCULAR DISEASE TREATMENT AND PREVENTION - The present invention generally relates to compositions and methods for treatment of subjects having or at risk of arteriosclerosis, hypertension, sickle-cell anemia, or other conditions. In some cases, the composition may include nitric oxide, peptides, or both. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like. | 2017-07-13 |
20170196982 | MACROLIDE DOSAGE FORMS - Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile. | 2017-07-13 |
20170196983 | TOPICAL COMPOSITION REPLACING WATER WITH HYALURONIC ACID AS THE PRIMARY INGREDIENT - A biologic formulation of 20% to 95% by weight of hyaluronic acid is provided such that the hyaluronic acid is the most common ingredient in the formulation. The formulation preferably also includes 0.1% to 1.5% by weight of a preservative, and a pH adjuster configured to provide a pH of less than 5.0 in the formulation. The hyaluronic acid is a combination of two or more different molecular weights of hyaluronic acid. The different molecular weights of hyaluronic acid are preferably cross-linked with glucosamine and ceramides. | 2017-07-13 |
20170196984 | PROTEIN POLYMER GOLD NANOPARTICLE HYBRID MATERIALS FOR SMALL MOLECULE DELIVERY - Protein polymer-gold nanoparticles, compositions comprising protein polymer-gold nanoparticles, and uses of protein polymer-gold nanoparticles. A protein polymer-gold nanoparticle comprises a gold core and a plurality of protein polymer molecules coordinated to the gold core via a poly-histidine tag present on each protein polymer molecule. A protein polymer molecule comprises one or more elastin-like polypeptide domain and a coiled-coil region of Cartilage Oligomeric Matrix Protein domain or a variant thereof. For example, the protein polymer-gold nanoparticles can be used in methods of small molecule delivery to an individual. | 2017-07-13 |
20170196985 | SULFUR(VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF - This application describes a compound represented by Formula (I): (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X | 2017-07-13 |
20170196986 | CONJUGATES OF CARBOXY POLYSACCHARIDES WITH FIBROBLAST GROWTH FACTORS AND VARIANTS THEREOF - Conjugates of hydrophilic carboxy polysaccharides with protein members of the fibroblast growth factor (FGF) family and variants thereof. The conjugates provide a modified bioactivity and stability of FGFs for various therapeutic applications. | 2017-07-13 |
20170196987 | METHODS FOR TREATING MULTIPLE SCLEROSIS - This invention is directed to a method for treating or preventing multiple sclerosis (MS), treating multiple sclerosis symptoms or preventing the continual chronic deterioration caused by multiple sclerosis (MS), comprising administering a conjugate of hydroxyproline and docosahexaenoic acid (DHA) according to formula MW-001. | 2017-07-13 |
20170196988 | USE OF ANTI-CD19 MAYTANSINOID IMMUNOCONJUGATE ANTIBODY FOR THE TREATMENT OF B-CELL MALIGNANCIES SYMPTOMS - An anti-CD19 maytansinoid immunoconjugate is used for treating B-cell malignancies symptom, in particular Non-Hodgkin's lymphoma. | 2017-07-13 |
20170196989 | RADIATION-STERILIZED BIODEGRADABLE DRUG DELIVERY COMPOSITIONS - The present disclosure is directed to a method of making a composition by combining a vehicle, e.g., a single phase vehicle, and an insoluble component comprising a beneficial agent, and sterilizing the composition using ionizing radiation prior to use, wherein the beneficial agent is stable following exposure to a sterilizing dose of ionizing radiation. Related compositions and methods are provided. | 2017-07-13 |
20170196990 | METHOD OF SYNTHESISING ADCS USING PHOTOCLEAVABLE LINKERS ON SOLID SUPPORT - Disclosed is a solid phase method of synthesising biomolecule-drug-conjugates (e.g. antibody-drug-conjugates) using photocleavable moieties. The method comprises: (i) providing an immobilised photocleavable group-biomolecule conjugate; (ii) optionally contacting the immobilised photocleavable group-biomolecule conjugate with a chemical modification agent or activating agent to provide an immobilised photocleavable group-biomolecule conjugate that is chemically modified or activated at the biomolecule portion; (iii) contacting the immobilised photocleavable group-biomolecule conjugate of step (i) or the chemically modified or activated immobilised photocleavable group-biomolecule conjugate of step (ii) with a drug component to form an immobilised photocleavable group-biomolecule-drug-conjugate; and (iv) irradiating the immobilised photocleavable group-biomolecule-drug-conjugate of step (iii) with radiation thereby releasing the biomolecule-drug-conjugate. | 2017-07-13 |
20170196991 | CYCLODEXTRIN-GRAFTED HYALURONIC ACID CROSSLINKED WITH DEXTRAN AND USES THEREOF - A hydrogel product including one or more cyclodextrin molecules grafted to hyaluronic acid and dextran, wherein the cyclodextrin-grafted hyaluronic acid is cross-linked to the dextran. The one or more cyclodextrin molecules are grafted, e.g. by amide bonds, to the hyaluronic acid prior to the cross-linking with dextran. The cyclodextrin-grafted hyaluronic acid may be cross-linked to the dextran by ether bonds. | 2017-07-13 |
20170196992 | METHODS AND COMPOSITIONS FOR ENGINEERING IMMUNITY - Nucleases and methods of using these nucleases for expressing an antibody from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom. | 2017-07-13 |
20170196993 | ULTRASHORT PEPTIDES AS EXOGENOUS SECOND HARMONIC PROBES FOR BIOIMAGING APPLICATIONS - Various aspects of the present invention relate to a peptide based biomaterial for visualization by SHG microscopy. In particular the invention relates to the use of short peptides as a non-linear optical (NLO) material for second harmonic generation (SHG) microscopy. A preferred short peptide comprises LIVAGK (LK6) and contains a non-polar aliphatic tail (with decreasing hydrophobicity) and a polar head; and can self-assemble into hydrogels; wherein which the peptide forms a tunable fibrous structure for in vitro and in vivo imaging applications and is suitable in disease diagnostics such as amyloidosis, including 1) neuro-degenerative amyloidosis, e.g. Alzheimer's (AD), Parkinson's, Huntington's (PD), 2) non-neuropathic localized amyloidosis such as in Type II Diabetes, and 3) systemic amyloidosis that occurs in multiple tissues, e.g. cataracts and lattice corneal dystrophy (LCD), as well as drug delivery and/or wound dressings. | 2017-07-13 |
20170196994 | MODELS OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND METHODS OF USE THEREOF - The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP. | 2017-07-13 |
20170196995 | OPTICAL IMAGING PROBES - The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject. | 2017-07-13 |
20170196996 | ACTIVATABLE ANTIBODIES THAT BIND EPIDERMAL GROWTH FACTOR RECEPTOR AND METHODS OF USE THEREOF - The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and using these anti-EGFR activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications. | 2017-07-13 |
20170196997 | RARE EARTH-BASED NANOPARTICLE MAGNETIC RESONANCE CONTRAST AGENT AND PREPARATION METHOD THEREOF - A rare earth-based nanoparticle magnetic resonance contrast agent and a preparation method thereof are provided. The rare earth-based nanoparticle magnetic resonance contrast agent is rare earth-based inorganic nanoparticles having the surfaces coated with hydrophilic ligands. The rare earth-based nanoparticles are first obtained by a high-temperature oil phase reaction, and then the surfaces thereof are coated with hydrophilic molecules to obtain the rare earth-based nanoparticle magnetic resonance contrast agent. Compared with the existing clinical contrast agent, the magnetic resonance contrast agent of the present invention has a greatly improved relaxivity, a good imaging effect, a low required injection dose, and long in vivo residence time. In addition, the rigid structure of the inorganic nanoparticles can effectively reduce the leakage possibility of gadolinium ions. | 2017-07-13 |
20170196998 | NANOPARTICLE CONTRAST AGENT FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE BY MAGNETIC RESONANCE IMAGING (MRI) - The disclosure herein relates to a novel nanoparticle that can cross the blood-brain barrier and form a bond with amyloid plaques and other related protein aggregates for detection by magnetic resonance imaging (MRI). The compositions, methods of making, and methods of use set forth herein also provide a non-invasive means for diagnosing Alzheimer's disease at an early stage. | 2017-07-13 |
20170196999 | Treatment of Meningiomas Using Phenylbenzothiazole, Stilbene, Biphenylalkyne, or Pyridine Derivitives - A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas. In one version of the method, the phenylbenzothiazole derivative is a compound of formula (V): | 2017-07-13 |
20170197000 | DEVICE FOR SANITIZING AIR-CONDITIONERS - A device for sanitizing a unit of an air conditioning system having a source of sanitizing fluid, means for the controlled delivery of a jet of sanitizing fluid, suctioning means to generate suction flow is provided. The device has suction opening shaped to direct the suction flow towards a determined direction with respect to the direction of the jet of sanitizing fluid. The suction opening is smaller than the unit of the air conditioning to be sanitized in order to be alternately moved from a first portion of the unit towards a second portion of the same unit. | 2017-07-13 |
20170197001 | LIGHT ILLUMINATING APPARATUS - Provided is a light illuminating apparatus irradiates a target object relatively moveable along a first direction with light. The apparatus includes a light source having a plurality of solid-state devices which irradiates the target object with the light in a second direction perpendicular to the first direction; a first reflecting part having at least one first reflecting surface placed at a downstream side in the second direction below the target object when viewed from the first direction, wherein the first reflecting part reflects a portion of the light from the light source incident on the first reflecting surface onto the target object; and a second reflecting part having a pair of second reflecting surfaces standing erect from the light source toward the first reflecting surface, wherein the second reflecting part guides the light from the light source into the first reflecting surface. | 2017-07-13 |
20170197002 | Flexible Article for UV Disinfection - A device including a flexible substrate and an ultraviolet radiation system is disclosed. The ultraviolet radiation system can include at least one ultraviolet radiation source configured to emit ultraviolet radiation towards a surface to be disinfected, an ultraviolet transparent component configured to focus the ultraviolet radiation, and a control system configured to control the at least one ultraviolet radiation source. The device can include a hand article, such as a glove. | 2017-07-13 |
20170197003 | STERILIZATION DEVICE AND METHODS - Embodiments of the present disclosure generally relate to devices and methods for sterilizing equipment. More particularly, one or more embodiments described in the present disclosure are directed to portable devices for sterilizing medical equipment in emergency situations. The sterilization devices and method of the present disclosure address an unmet need for sterilizing surgical equipment in a manner that is not only effective and time-efficient, but is also portable and reliable enough to use in emergency medical situations in remote locations where modern sterilization equipment is not available. | 2017-07-13 |
20170197004 | APPARATUS AND METHOD FOR GENERATING AROMATIC SMELL IN ELECTRONIC DEVICE - An aromatic smell generation apparatus of an electronic device is provided. The aromatic smell generation apparatus includes a protection case including a cover on one side that protects a display of the electronic device and an electronic device mounting portion on an other side in which the electronic device is located, a cartridge attachment portion to detachably receive different types of a plurality of aromatic smell generation cartridges, and a controller that controls a type and a diffusion time of a perfume stick within the plurality of aromatic smell generation cartridge according to a preset event. | 2017-07-13 |
20170197005 | DISINFECTION OF A CONTAMINATED ENVIRONMENT - A formulation to reduce the numbers of bacteria, particularly Gram positive bacteria, in a space such as a waste disposal bin, via the vapour phase, and active over a long period, typically several weeks. The product comprises one or more essential oils or essential oil components plus a mixture of volatile and non-volatile solvents, on a carrier such as a non-woven, sintered plastic or cardboard. | 2017-07-13 |
20170197006 | HONEY-BASED FOAM COMPOSITIONS - Provided are compositions for wound treatment comprising foam impregnated with honey, methods of making such compositions, and methods of treating wounds with such compositions. | 2017-07-13 |
20170197007 | DIAGNOSTIC COMPOSITION FOR IDENTIFYING AMNIOTIC FLUID - The present invention relates to the field of medical diagnostics and more specifically, to identification of amniotic fluid. | 2017-07-13 |
20170197008 | NEW SINGLE-STEP MANUFACTURING PROCESS FOR FOAMED BIOMATERIALS - Processes for the preparation of biomaterials, in particular foams and solid structures, suitable for bone surgery and odontology, bone regeneration, bone defect fillings, stabilizing bone fractures, coating of prostheses or implants, fixing of prostheses or implants, drug delivery systems, and tissue engineering scaffolds, and to the biomaterials obtained thereby. Besides that, this invention, also relates to self-setting calcium phosphate foams which may be obtained by simultaneously mixing and foaming of a powder phase and a liquid phase. | 2017-07-13 |
20170197009 | Sterilized Thermogelling Composition - The invention relates to a sterilized thermogelling composition comprising a chitosan having N-acetyl-glucosamine units, glucosamine units, and substituted glucosamine units other than the N-acetyl-glucosamine units, said substituted chitosan preferably having a degree of substitution of the glucosamine units ranging from 10 to 50%, expressed as a number of moles of the substituent based on the number of moles of total units, to its preparation and to its applications. | 2017-07-13 |
20170197010 | COMPOSITE BONE GRAFT DEVICE - A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged within a resorbable mesh casing. | 2017-07-13 |
20170197011 | METHODS FOR REPAIRING CARTILAGE DAMAGE - A method for repairing cartilage damage comprising (a) creating a microfracture or performing other bone marrow stimulation techniques on a patient inflicted with cartilage damage; and (b) administering a composition to the microfracture, wherein the composition comprises an agent capable of regenerating organized hyaline cartilage. | 2017-07-13 |
20170197012 | THERMOSENSITIVE BIODEGRADABLE HYDROGEL - There is provided a thermosensitive biodegradable hydrogel including MPEG-PCL to which a cell-adhesive peptide binds, and MPEG-PCL. The thermosensitive biodegradable hydrogel has excellent cellular adhesiveness while maintaining thermosensitivity of polymers intact, and is biodegradable in vivo after a predetermined period of time. | 2017-07-13 |
20170197013 | BONE IMPLANT MATERIALS COMPRISING CROSS-LINKED BIOACTIVE HYDROGEL MATRICES - The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking. | 2017-07-13 |
20170197014 | ANTIBACTERIAL BIOMEDICAL IMPLANTS AND ASSOCIATED MATERIALS, APPARATUS, AND METHODS - Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process. | 2017-07-13 |
20170197015 | Nickel Titanium Oxide Coated Articles - This disclosure relates to an article comprising at least one substrate and at least one porous coating formed on the at least one substrate. The substrate may be a medical device, for example a Nitinol stent. The porous coating may comprise a nanotubular coating. The nanotubular coating may comprise a compound of nickel, titanium and oxygen. This porous coating may improve re-endothelialization and/or reduce restenosis when it is used in the treatment of cardiovascular diseases. | 2017-07-13 |
20170197016 | Method for enhancing postoperative healing using low pressure suction apparatus - A method for enhancing postoperative healing using a low pressure suction apparatus comprising obtaining a preferably both electrically powered and portable treatment apparatus capable of contacting, via a treatment head, a target area of a patient and introducing low-pressure suction, i.e. negative pressure flow, thereto, configuring the treatment apparatus so as to introduce predefined, advantageously, pulsating pressure variation to a suction opening arranged at the treatment head, and applying the suction opening of the treatment head on the target area before the surgery, i.e. during the preoperative period, and optionally after the surgery, while the treatment apparatus is on and providing the suction effect corresponding to the configuration. | 2017-07-13 |
20170197017 | IMAGE-GUIDED IRRIGATING SUCTION CANNULA FOR REMOVAL OF INTRACEREBRAL HEMORRHAGE AND OTHER LESIONS - A minimally invasive surgery device for image-guided removal of lesions in the brain by providing suction and irrigation through a small cranial opening. One particular use is for evacuation of intracerebral hemorrhage. Other uses may include evacuation of pus from an abscess, or cystic fluid or necrotic debris from a tumor. | 2017-07-13 |
20170197018 | MOTORIZED CHEST DRAINAGE SYSTEM - A chest drainage system is disclosed, including a flexible tube with an articulable tip and a control assembly. The control assembly is operated by a motor and includes an actuation assembly. The actuation assembly is operatively coupled with the flexible tube and is adapted to articulate the tip. | 2017-07-13 |
20170197019 | CONNECTOR FOR FLUID COMMUNICATION BETWEEN TWO ANATOMICAL COMPARTMENTS - A connector is provided for fluid communication between two anatomical compartments through at least one anatomical wall, wherein the connector comprises a neck adapted and configured to be positioned across the anatomical wall(s); primary means for securing the neck across the anatomical wall(s); and secondary means for securing the neck across the anatomical wall(s). A method for coupling two anatomical walls using said connector is also provided. | 2017-07-13 |
20170197020 | METHOD OF HEAT SANITIZATION OF A HAEMODIALYSIS WATER CIRCUIT USING A CALCULATED DOSE - A method of sanitizing liquid for use in a medical device, the method comprising the steps of providing a medical device defining a water circuit with a volume of liquid, sensing the temperature of the volume of liquid with a sensor, heating the volume of liquid from an initial temperature to exceed a threshold temperature, maintaining the volume of liquid above the threshold temperature, determining a time-temperature value for the volume of liquid periodically once the threshold temperature has been exceeded, calculating a cumulative time-temperature value and providing an output signal once the cumulative time-temperature value has reached a level indicative of a sanitizing dose. A medical device and a liquid sanitizer are also disclosed. | 2017-07-13 |
20170197021 | System and Method for Treating Pulmonary Edema - Systems, methods, and devices are provided for the treatment of edema. In one aspect a method for implanting an indwelling catheter within a vein of a patient is provided. The catheter can extend from a position upstream of at least one outflow port of a duct of the lymph system to a terminal position downstream of the at least one outflow port. In use, a first restriction can be created within the vein proximal to a distal region of the catheter. The first restriction can define a localized low pressure zone distal of the restriction and within a portion of the vein housing the catheter. The low pressure zone can be adjacent to the at least one outflow port to enable fluid to pass from the at least one lymph duct outflow port into the vein. | 2017-07-13 |
20170197022 | METHOD FOR FILLING AND RINSING A SET OF BLOOD LINES - A method for the filling and flushing of a blood tube set including a pump segment for a blood pump, an arterial line connected to an inlet of a dialyser, a venous line connected to an outlet of a dialyser, a substituate line connected to a substitute port and having a pump segment for a substitute pump, and a three-way connector connected to the arterial line, the venous line and a rinse port. The method includes the steps of opening the rinse port, filling and simultaneously flushing the arterial and venous lines with the substituate supplied from the substitute line via the substitute pump, while substituate is drained off via the rinse port, closing the rinse port, and circulating the substituate in the circuit of arterial line, dialyser and venous line by the blood pump. | 2017-07-13 |
20170197023 | SYSTEM AND METHOD FOR PLASMA PURIFICATION PRIOR TO MONONUCLEAR CELL COLLECTION - A method of collecting mononuclear cells, comprising separating whole blood into plasma and cellular components, combining the cellular components with plasma replacement fluid to form a first mixture, and separating the first mixture into mononuclear cells and at least one component. | 2017-07-13 |
20170197024 | MEDICAL CONTAINER FOR ACCOMMODATING PROTEIN SOLUTION FORMULATION - A medical container for accommodating a protein solution formulation, in which the medical container is formed from a cycloolefin polymer, sterilized with high-pressure steam, and suppresses oxidization of amino acid residues in a protein in a protein solution formulation accommodated in the medical container. | 2017-07-13 |
20170197025 | DOSE REQUEST SYSTEMS AND METHODS - A dose request device for a medicament delivery device can include a housing, a dose request button, a short-range non-contact identifier, a communication interface configured to communicate with the medicament delivery device, and a controller. The short-range non-contact identifier can be configured to be capable of reading an identification code from a tag when the tag is disposed within a first range and not to be able to read the identification code from the tag when the tag is disposed beyond a second range. The controller can be configured and programmed to determine whether the identification code read by the short-range non-contact identifier matches any authorized identification code of a set of one or more authorized identification codes, and if so, and if the dose request button is pressed, the controller can then communicate a dose request to the medicament delivery device via the communication interface. | 2017-07-13 |
20170197026 | METHODS CIRCUITS DEVICES ASSEMBLIES SYSTEMS AND FUNCTIONALLY ASSOCIATED COMPUTER EXECUTABLE CODE FOR TRANSPORTING OR PROVIDING FLUID TO A PATIENT - Disclosed is a medical device including a pumping mechanism for administering a fluid to a patient, where the pumping mechanism is characterized as having two or more treatment routes by which to connect to a patient, a controller for controlling the pumping mechanism, one or more inputs for receiving information including an intended route indication, and a display to visually label the medical device according to the selected route indication. | 2017-07-13 |
20170197027 | SYSTEM AND METHOD FOR INSULIN PUMP MEDICAL DEVICE INCLUDING A SLIDER ASSEMBLY WHEREIN IMAGES ON DISPLAY ALLOW FOR HIGHLIGHTING AND MAGNIFYING IMAGES - A medical system includes an input assembly for receiving one or more user inputs. The input assembly includes at least one slider assembly for providing an input signal. Processing logic receives the input signal from the input assembly and provides a first output signal and a second output signal. A display assembly is configured to receive, at least in part, the first output signal from the processing logic and render information viewable by the user. The second output signal is provided to one or more medical system components. The information rendered on the display assembly may be manipulatable by the user and at least a portion of the information rendered may be magnified. | 2017-07-13 |
20170197028 | Nonjacketing side-entry connectors and prosthetic disorder response systems - Provided is a connector suitable for securely infixing a catheter, electrode, hollow needle, probe, or other styliform device with its tip stabilized within a nontubular anatomical structure. Secure junctions between fluid lines and/or electrodes and tissue are essential for automatic controls and permanent nephrostomies and suprapubic cystostomies, for example, using synthetic materials. These can be made self-contained and fully implanted to treat one chronic condition, or represent but one module controlled as an axis or channel of control in an adaptive ambulatory hierarchical prosthetic disorder response system used to automatically coordinate the treatment of chronic comorbid disease. Such applications require prosthesis-to-native tissue junctions which are secure, immobile, unsusceptible to leaks or microbial intrusion, and require little if any maintenance. Connection for securely and least disruptively merging catheteric and native lumina is described in nonprovisional application Ser. No. 14/121,365, entitled Ductus Side-entry Jackets and Prosthetic Disorder Response Systems, filed on 25 Aug. 2014. | 2017-07-13 |
20170197029 | Patch-Like Infusion Device - A system and method for a patch-like, self-contained substance infusion device which can be attached to a skin surface via an adhesive contact surface. A push button activation assembly can then be used to remove an interlock, allowing a disk or Belleville spring assembly to apply an essentially even and constant pressure to the contents of a fluid reservoir assembly. This allows the release of one or more spring-loaded patient needles into the skin surface, and establishes a fluid communication path between the patient needles and the pressurized fluid reservoir contents thereby delivering an infusion into the skin. The push button activation assembly further allows the release of one or more improved safety mechanisms after use. | 2017-07-13 |
20170197030 | APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS, DEVICES, AND RELATED METHODS - A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters. | 2017-07-13 |
20170197031 | PREFILLED DISPOSABLE INJECTION DEVICE - The present invention relates to a drug delivery device comprising a drug container comprising at least one bellow, wherein the at least one bellow comprises a first surface and an opposing second surface, wherein the first surface is comprised of a first Belleville spring and the opposing second surface is comprised of a second Belleville spring, wherein the second Belleville spring has a higher spring rate than the first Belleville spring. | 2017-07-13 |
20170197032 | MULTI-DIRECTIONAL LOW-DISPLACEMENT FORCE SENSOR - A device for the measurement of forces on the tip of a jet injector drug ampoule. Sensor consists of multiple spokes with strain sensing capability where each spoke has formations to allow for quasi-free bending behavior on one spoke end. By using the strain output of all three full bridges in parallel, it is possible to discriminate between lateral forces and axial forces directed collinear with the center axis of the ampoule applied to the tip of the nozzle. This information can be relayed to the user to attain, for example, a pre-determined contact force between the nozzle and an area receiving an injection. | 2017-07-13 |
20170197033 | ADAPTER, PROCESS AND USE FOR INSTILLATION OF AGENTS INTO THE BLADDER THROUGH THE URETHRA WITHOUT CATHETER - An adapter is provided with a central, longitudinal, inner through hole and has a rounded off tip-part to be inserted into the external urethral orifice, a sealing collar and a cylindrical connecting part known connectable to the appropriate part of a dosing device, advantageously to the ISO 594 standard Luer Slip or Luer-Lock tip of a syringe. The adapter is connected by known method to the appropriate part of a dosing device containing the active and/or contrast agent, then the active and/or contrast agent is ingested leakage-free into the urethra or into the urethra and the bladder through the adapter, then through the external urethral orifice by using overpressure in the dosing device and inserting the tip-part into the external urethral orifice and squeezing the sealing collar in a proper way to the external urethral orifice. | 2017-07-13 |
20170197034 | NEEDLELESS INJECTION DEVICE WITH DOUBLE MEMBRANE - The invention relates to a needleless injection device or a device for the needleless injection of a substance into a tissue or body, with which device a substance, in particular an active substance, can be injected by means of high pressure. A device according to the invention comprises a chamber ( | 2017-07-13 |
20170197035 | NEEDLE ASSEMBLY AND DRUG INJECTION DEVICE - A needle assembly includes: a retaining portion; and an elastic member that includes a close contact portion that closely contacts and retains the needle tube such that the needle tube protrudes toward a fitting opening, and a deformation portion that extends from the close contact portion toward the fitting opening and is configured to deform when the drug ejection portion comes into contact with the elastic member, and which is provided in a fitting portion. Further, the length of the deformation portion is in a range of 35% or more and 50% or less with respect to the length of the elastic member, and the length of a portion of the needle tube which protrudes from the close contact portion toward the fitting portion is in a range of 45% or more and 245% or less with respect to the deformation portion. | 2017-07-13 |
20170197036 | Auto-Injector - The invention relates to an auto-injector ( | 2017-07-13 |
20170197037 | SUBSTANCE DELIVERY APPARATUS, SUBSTANCE DELIVERY SYSTEM AND METHOD OF SUBSTANCE DELIVERY - An apparatus for discharging a dose of a fluid substance to an animal, the apparatus including: a delivery assembly adapted to discharge the dose of the substance to the animal; and a control system operatively associated with the delivery assembly so as to selectively operate the delivery assembly, wherein the control system is adapted to measure the discharge of the fluid substance from the delivery assembly such that the dose is discharged when the delivery assembly is operated. | 2017-07-13 |
20170197038 | INJECTION DEVICE WITH TOOTHED GEARING - An injection device has a housing in which a syringe can be received that has an injection needle, a receiving chamber, a piston and a piston ram, and a control arrangement for controlled actuation of the syringe during an application procedure that includes at least one puncture stroke, one injection stroke and one return stroke. The control arrangement has an actuation element for applying a drive force to a syringe holder which is movable relative to the housing and on which the receiving chamber can be secured, a ram holder which is movable relative to the housing and on which the piston ram can be secured, and a transmission mechanism by means of which the ram holder can be coupled to the actuation element. Provision is made that the transmission mechanism has a toothed gearing by means of which the ram holder can be driven, according to a relative movement of the actuation element with respect to the housing, and which for this purpose has teeth on the housing. | 2017-07-13 |
20170197039 | SYRINGE CAP, SYRINGE WITH NEEDLE, AND PREFILLED SYRINGE FORMULATION - Provided is a syringe cap including a projection extending in the circumferential direction of a cap body, wherein the projection includes an apex located radially outward of the cap body from the outer circumferential surface of the cap body, a first inclined surface having a starting end located at the apex and having a terminal end located at a position on the side closer to the proximal end of the cap body than the starting end is, and a second inclined surface having a starting end located at the apex and on the outer circumferential surface of the cap body having a terminal end located at a position on the side closer to the distal end of the cap body than the starting end is, on the outer circumferential surface of the cap body, and the shortest distance from the starting end to the terminal end of the first inclined surface is smaller than the shortest distance from the starting end to the terminal end of the second inclined surface. | 2017-07-13 |
20170197040 | SYRINGE ASSEMBLY, CAP, AND PUNCTURE NEEDLE - A syringe assembly includes a barrel having a barrel tip portion, a puncture needle projecting from the barrel tip portion, and a cap that is detachably mountable to the barrel so as to seal a distal end of a needle hole. The cap has a receiving hole that receives the puncture needle, a bottom wall portion into which the puncture needle is inserted, and a stopper portion that defines an insertion length of the puncture needle relative to the bottom wall portion. In a state in which the cap is mounted to the barrel, the length from the most proximal position of a contact region between the cap and the puncture needle to the most proximal position of an edge surface is 1 to 3 mm. | 2017-07-13 |
20170197041 | INHALATION DEVICE - An inhaler is disclosed wherein medicament in a dosing chamber is aerosolized with a vibrator piezoelectric transducer. A spacer is provided between a face of the transducer and a wall of the dosing chamber. | 2017-07-13 |
20170197042 | HUMIDIFYING DEVICE - A nebulizer includes: a suction mechanism configured to suck a liquid for humidification from a water bottle containing the liquid and form an aerosol of the sucked liquid by a negative pressure produced by an oxygen gas jetted from a gas jetting part of a nozzle member; a liquid receptor configured to store the liquid residing in the form of droplets into which the aerosol turns; and a receptor-side aerosol forming member configured to suck the liquid from the liquid receptor and form an aerosol of the sucked liquid by the negative pressure. Consequently, germs are prevented from getting into the liquid in a container during use, and the liquid is prevented from dripping when the container is replaced. | 2017-07-13 |
20170197043 | INHALER - The present disclosure relates to an inhaler component for producing a steam/air mixture or/and condensation aerosol in an intermittent and inhalation- or pull-synchronous manner, the inhaler component including: a housing; a chamber arranged in the housing; an air inlet opening for the supply of air from the surroundings to the chamber; an electrical heating element for evaporating a portion of a liquid material; and a wick having a capillary structure, which wick forms a composite structure with the heating element and automatically supplies the heating element with fresh liquid material after evaporation. | 2017-07-13 |
20170197044 | INHALER - The present disclosure relates to an inhaler component for producing a steam/air mixture or/and condensation aerosol in an intermittent and inhalation- or pull-synchronous manner, the inhaler component including: a housing; a chamber arranged in the housing; an air inlet opening for the supply of air from the surroundings to the chamber; an electrical heating element for evaporating a portion of a liquid material; and a wick having a capillary structure, which wick forms a composite structure with the heating element and automatically supplies the heating element with fresh liquid material after evaporation. | 2017-07-13 |
20170197045 | INTERNALLY PRESSURIZED MEDICAL DEVICES - There are provided pressurized surgical instruments for use in pressurized surgical environments. The pressurized surgical instruments include pressurizing systems for maintaining a neutral or positive pressure flow within the surgical instrument during use. The pressurizing systems include a primary sensor for detecting the pressure of the surgical environment and a pressurizing mechanism for balancing the pressure of the surgical instrument with the surgical environment. The pressurizing mechanism includes a controller to receive and compare the signal sent from the primary sensor to the ambient or internal instrument pressure and a pressure delivery system to provide positive pressure to the interior of the surgical instrument in response to a signal received from the controller. The sources of pressure for the pressure delivery systems may be external or self contained within the surgical instrument. | 2017-07-13 |
20170197046 | INHALER - The present disclosure relates to an inhaler component for producing a steam/air mixture or/and condensation aerosol in an intermittent and inhalation- or pull-synchronous manner, the inhaler component including: a housing; a chamber arranged in the housing; an air inlet opening for the supply of air from the surroundings to the chamber; an electrical heating element for evaporating a portion of a liquid material; and a wick having a capillary structure, which wick forms a composite structure with the heating element and automatically supplies the heating element with fresh liquid material after evaporation. | 2017-07-13 |
20170197047 | PORTABLE ELECTROMECHANICAL RESUSCITATOR BAG COMPRESSION DEVICE - A portable device including a housing comprising a first opening and a second opening and a resuscitator bag. The resuscitator bag is disposed at least partially within the housing and includes an air inlet supported at the first opening of the housing, an air outlet supported at the second opening of the housing, and a self-inflating bag. The portable device also includes a double-sided compression mechanism disposed within the housing. The double sided-compression mechanism includes a pair of arms at least partially surrounding the self-inflating bag. The pair or arms are configured to move towards each other to compress the self-inflating bag to provide positive pressure ventilation via the air outlet and to move away from each other to enable re-inflation of the self-inflating bag via the air inlet; and, a motor coupled to the pair of arms for moving the pair of arms towards and away from each other. | 2017-07-13 |
20170197048 | SUBGLOTTIC ASPIRATION DEVICE - A computer-controlled vacuum suctioning device for subglottic aspiration, in which the timing of the pump operation is regulated so as to be synchronized with the operation of a mechanical respirator. | 2017-07-13 |
20170197049 | Endotracheal Tube and Nasogastric Tube Attachment Device - An endotracheal tube and gastrointestinal tube attachment device for positively securing an endotracheal tube and a gastrointestinal tube to a patient and allowing selective lateral positioning and locking of the gastrointestinal tube without removing the device or tube from the patient is disclosed. The device includes an elongated strip of flexible material adapted to be adhesively attached to an upper lip region of a patient and a tube holder which is slideably mounted upon the strip. The tube holder has an arm extending in a direction perpendicular to and away from the strip and a securement strap is provided for positively securing the endotracheal tube along the length of the arm. The strip includes a fastener for fastening the gastrointestinal tube. | 2017-07-13 |
20170197050 | SYSTEM AND METHOD FOR SECURING A BREATHING GAS DELIVERY HOSE - A system and method for supporting a patient gas delivery tube includes an elongated support member having a cylindric cross section and including first and second distal ends. A generally planar, rigid base secures the first distal end so as to extend from a surface of the base. The support member includes a biasing portion configured to bias arcuate movement between the first and second distal ends. A mount secured to the second distal end secures an associated tube to the second distal end. | 2017-07-13 |
20170197051 | Novel Airway Tube Stabilizer - A novel tube stabilizer with a collar and an aperture. A tube from a medical airway device can pass through the aperture. The laryngeal mask stabilizer slides along the tube and fits into the mouth of a patient on which an airway device is being used during a medical procedure. The apparatus stabilizes the airway tube. | 2017-07-13 |
20170197052 | Medical mask for EGD, ERCP and bronchoscopy - An improved medical gas supply mask adapted to allow insertion of a broncoscope or endoscope into a patient's mouth without removing the mask. The mask's gas supply portal is located below the mouth instead of directly below the nose. The mask has an attached, typically extendable, tubular bite block that has an outer orifice on the outside of the mask. The surgeon can thus manipulate a scope tube or other instrument into the esophagus or trachea as desired while still providing oxygen to the patient. The mask includes small closed side-ports to receive items like a CO2 monitor tube and the like. Instruments up to approximately 4 cm may be inserted. | 2017-07-13 |
20170197053 | TRANSORAL PROCEDURE MASK - The system of the preferred embodiments includes a mask shell, where an opening of at least one square inch is located in the mask over the user's mouth, where the mask shell is designed to fit over the user's mouth and nose; a strap connected to either lateral side of the mask shell and adapted to go at least one of behind the user's head and around the user's ears to pull the mask onto the user's face; an oxygen supply tube connected to the side of the mask shell over the user's cheek, and in fluid communication with the inside of the interior cavity of the mask shell; a second tube connected within a half inch of the oxygen supply tube, wherein the distal end of the second tube connects to a carbon dioxide sensor, wherein the second tube is adapted to convey exhaled gas to the carbon dioxide sensor. The transoral procedure mask of the first preferred embodiments is preferably designed to allow simultaneous delivery of high flow rates of oxygen to a patient's nose and mouth while also allowing access into the patients mouth of one or more of instruments and tools, while not having nasal prongs which can lead to nasal burning in patients at high flowrates, and while having an integrated tube for connection to a carbon dioxide partial pressure sensor to provide constant and convenient oxygenation monitoring. The system of the first preferred embodiments may, however, be used for any suitable reason. | 2017-07-13 |
20170197054 | FIXING TOOL FOR ATTACHING ARTIFICIAL VENTILATOR - A fixing tool for attaching an artificial ventilator includes a forehead-side fixing band | 2017-07-13 |
20170197055 | MEDICAL TUBES AND CONNECTORS FOR GASES DELIVERY SYSTEMS - A medical circuit comprising a medical tube and a connector transports gases to and/or from a patient via a patient interface. The connector has a plurality of rigid components at least partially surrounded by an overmold. The medical tube has a first elongate member and a second elongate member. The first elongate member is substantially hollow. A vent can be coupled to the first elongate member such that it maintains gaseous communication with the lumen. The vent may provide a pathway between the lumen and the atmosphere, such that gases may move into and/or out of the lumen during cleaning. The vent may also provide a barrier to liquid and/or substance ingress into the first elongate member during cleaning of the medical circuit. The medical circuit can be reusable. | 2017-07-13 |
20170197056 | GASES MIXING AND MEASURING FOR A MEDICAL DEVICE - A gases humidification system includes a measuring chamber and a mixing chamber. The mixing chamber has one or more mixing elements that improve a mixing of gases before reaching the measuring chamber. Ultrasonic sensing is used to measure gases properties or characteristics within the measuring chamber. A baffle or a vane may be used to control and direct the gases flow through the mixing chamber as the gases flow moves into the measuring chamber. | 2017-07-13 |
20170197057 | FLOW MIXERS FOR RESPIRATORY THERAPY SYSTEMS - A flow of gases in a respiratory therapy system can be conditioned to achieve more consistent output from sensors configured to sense a characteristic of the flow. The flow can be mixed by imparting a tangential, rotary, helical, or swirling motion to the flow of gases. The mixing can occur upstream of the sensors. The flow can be segregated into smaller compartments to reduce turbulence in a region of the sensors. | 2017-07-13 |
20170197058 | CONVERSION OF NITROGEN DIOXIDE (NO2) TO NITRIC OXIDE (NO) - Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. | 2017-07-13 |
20170197059 | MEDICAL DEVICE - The invention provides a medical device including a resin tube having excellent branch selectivity while excellent pushability in a curved body cavity or an extremely narrow body cavity such as a blood vessel terminal region is maintained. Provided is a medical device having a medical device body to be inserted into a body cavity. The medical device body has an elongated resin tube, the resin tube includes a first region including a distal end part and a second region including a proximal end part, and the first region is more flexible than the second region. | 2017-07-13 |
20170197060 | ASYMMETRIC CATHETER CURVE SHAPES - A deflectable catheter shaft with compression resistance coils is configured to create different curve shapes when the catheter is steered or deflected in different directions. One or more compression resistance coils include an elongated-pitch section. The compression resistance coils may be pull wire compression coils or body compression coils. | 2017-07-13 |