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28th week of 2013 patent applcation highlights part 44
Patent application numberTitlePublished
20130178618NOVEL PHARMACEUTICAL INTERMEDIATES AND METHODS FOR PREPARING THE SAME - A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally carboxylated azonane moiety, or a second, optionally carboxylated indole moiety, having an alkyl, allyl, phenylallyl, cinnamyl, alkenyl, and/or alkyl-alkenyl substituent pendant from a nitrogen atom of the same.2013-07-11
20130178619PROCESSES FOR THE PREPARATION OF 8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES RELATED THERETO - The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.2013-07-11
20130178620PROCESSES FOR PREPARING 3-BENZAZEPINES - The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.2013-07-11
20130178621PROCESS FOR PREPARING TRANSITION METAL-CARBENE COMPLEXES - Process for preparing cyclometallated transition metal-carbene complexes comprising at least one carbene ligand, which comprises reacting a ligand precursor with a base, an auxiliary reagent and a metal complex comprising at least one metal M2013-07-11
20130178622Methods and Compositions for Treating Cancer - The invention features methods, kits, and pharmaceutical compositions for treating cancer using 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)-methyl)-3-(trifluoromethyl)phenyl)benzamide.2013-07-11
201301786234-AMINO-3-(IMIDAZOLYL)-PYRAZOLO[3,4-D]PYRIMIDINES - Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are 4-amino-3-imidazoyl-pyrazolo[3,4-d]pyrimidine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.2013-07-11
20130178624QUINAZOLINE DERIVATIVES - The present invention concerns the compounds of formula2013-07-11
20130178625P 2 X 4 RECEPTOR ANTAGONIST - A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X2013-07-11
20130178626Bootstrapping and Synthesis of Mechanosynthesis Tips - Processes are described for manufacturing atomically-precise tips using one or more tips in one or more mechanosynthetic reactions to create one or more atomically-precise tips. The processes may employ a variety of feedstock, binding any of a wide range of atoms to a workpiece to build the one or more atomically-precise tips. The processes result in atomically-precise mechanosynthesis tips with a wide variety of possible tip structures using a wide range of feedstock binding elements. Characteristics of such tips that may be used when designing new embodiments are also described.2013-07-11
20130178627Methods, Systems and Workpieces Using Mechanosynthesis - Methods and systems for building three-dimensional workpieces are described using a plurality of mechanosynthetic reactions. These methods may employ engineered reliability in reactions and process conditions and may use simulated or otherwise vetted reaction sequences, to allow workpieces requiring many reactions to be built with acceptable reliability. These many reactions may be the repetition of one or a small number of reactions, or many diverse reactions, or a combination thereof.2013-07-11
20130178628FLUOROALKYLFLUOROPHOSPHORANE ADDUCTS - The invention relates to fluoroalkylfluorophosphorane adducts and the use thereof for masking OH groups in organic compounds.2013-07-11
20130178629SYNTHESIS OF 4H-BENZO[D]PYRROLO[1,2-A]THIAZOLES AND INDOLIZINO[6,7-b]INDOLE DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS - The present invention provides a series of 2,3-bis(hydroxymethyl)-4H-benzo[d]pyrrolo-[1,2-a]thiazoles and 1,2-bis(hydroxymethyl)indolizino[6,7-b]indole derivatives and their bis(alkylcarbamates) derivatives. These derivatives were designed as bi-functional DNA cross-linking agents. The in vitro cytotoxicity study of these compounds revealed that they exhibit significant anti-proliferative activity in inhibiting human lymphoblastic leukemia and various solid tumor cell growth. The compounds also exhibit therapeutic efficacy against human breast carcinoma and lung cancer in xenograft model. The compounds generally possess potent antitumor activity to kill various human solid tumors and have high potential for clinical applications.2013-07-11
20130178630PROCESS FOR MAKING HCV PROTEASE INHIBITORS - Efficient processes for making HCV protease inhibitors are described. In one embodiment, the process uses novel idazolide derivatives of vinyl-ACCA.2013-07-11
20130178631NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS - The present invention relates to novel compounds of formula I wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors—subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.2013-07-11
20130178632Transition-Metal-Catalyzed Carbon-Nitrogen and Carbon-Carbon Bond-Forming Reactions - One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.2013-07-11
20130178633PHENOL DERIVATIVES AND THE PHARMACEUTICAL OR COSMETIC USE THEREOF - The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I):2013-07-11
20130178634Process for Preparing Substituted N-Phenylhydroxylamines - The present invention relates to a process for the preparation of a ring-substituted N-phenylhydroxylamine by reduction of the correspondingly substituted nitrobenzene compound, wherein the reduction is carried out by reacting the substituted nitrobenzene compound with hydrazine in the presence of a ruthenium catalyst.2013-07-11
20130178635PROCESS FOR THE PREPARATION OF THE L-ARGININE SALT OF PERINDOPRIL - Process for the preparation of the compound of formula (I):2013-07-11
20130178636ESTERS OF HEXANOIC ACIDS AS INTERMEDIATES FOR THE PREPARATION OF ATORVASTATIN - The invention relates to compounds of general formula (3) wherein R2013-07-11
20130178637PROCESSES FOR THE PRODUCTION OF PYRROLIDONES - Processes for making pyrrolidones include providing a clarified diammonium succinate (DAS)-containing and/or monoammonium succinate (MAS)-containing fermentation broth; distilling the broth under super atmospheric pressure at a temperature of greater than 100° C. to about 300° C. to form an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling and/or evaporating the bottoms to attain a temperature and composition sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; and converting the solid SA portion to pyrrolidones.2013-07-11
20130178638PROCESS FOR PRODUCING DIOXOLANE - A process is described for producing dioxolane from crude glycerol obtained from raw materials such as the crude glycerol obtained during production of biodiesel or glycerol obtained during conversion of fats or oils. Further, the described method can dissolve the glycerol in an organic solvent and form an insoluble phase including salts included in the crude glycerol, and then react the glycerol obtained with an aldehyde or a ketone.2013-07-11
20130178639CRYSTALLINE FORMS OF DIMETHOXY DOCETAXEL AND METHODS FOR PREPARING THE SAME - The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β, 10β-dimethoxy-9-oxo-tax-11-ene-13α-yle, and to the preparation thereof.2013-07-11
20130178640RENEWABLE FATTY ACID WAXES AND METHODS OF MAKING - Natural oil based fatty acid wax compositions and their methods of making are provided. The methods comprise providing a natural oil, and hydrogenating and metathesizing the natural oil, and then converting the hydrogenated metathesized natural oil to obtain a fatty acid wax comprising free fatty acids and/or salts of fatty acids, glycerol and/or alcohol, and paraffin, wherein the fatty acid wax has at least 50 wt % of carbon chain compositions with at least 18 carbon atoms. The compositions may comprise 85-100 wt % long-chain fatty acids, 0-15 wt % esters, wherein the fatty acid comprises between 15-60 wt % long chain di-acids and 40-85 wt % long chain mono-acids. The compositions may comprise about 50-100 wt % long-chain fatty acids and about 0-50 wt % esters, wherein the fatty acid may comprise between about 15-80 wt % long chain di-acids and about 20-85 wt % long chain monoacids.2013-07-11
20130178641RUBIDIUM AND CESIUM COMPOUNDS FOR TWO-PHOTON ABSORPTION - A material which electronically isolates a rubidium or cesium atom, which is bonded to only one or two oxygen atoms. This electronic isolation is manifested in narrow photoluminescence emission spectral peaks. The material may be an alkali metal compound comprises the empirical formula: AM(R2013-07-11
20130178642METHOD OF PREPARING BIPHENYL-4-YL DIPHENYL PHOSPHATE COMPOSITION - Provided is a method of preparing a biphenyl-4-yl diphenyl phosphate composition for use as a flame retardant or a plasticizer for resin, including mixing phosphoryl chloride (POCl2013-07-11
20130178643Isocyanates and Aromatic Hydroxy Compounds - An object of the present invention is to provide a process for producing isocyanates, which are industrially useful compounds, without using phosgene, and to provide a process for chemically recycling waste polycarbonate resin. The present invention discloses a process enabling isocyanate compounds to be produced without using phosgene as a raw material by subjecting a carbamic acid ester compound obtained by a reaction between an aromatic polycarbonate resin and an amine compound to a thermal decomposition reaction, while at the same time disclosing a process enabling chemical recycling of aromatic polycarbonate resin by recovering a divalent aromatic hydroxy compound forming aromatic polycarbonates.2013-07-11
20130178644PROCESS FOR THE SYNTHESIS OF TAPENTADOL AND INTERMEDIATES THEREOF - The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high stereoselectivity due to the presence of the benzyl group as substituent of the amino group. It was surprisingly found that this substitution shifts the keto-enol equilibrium towards the desired enantiomer and amplifies the capacity of the stereocenter present in the compound (VII) to orient the nucleophilic addition of the organometallic compound at the carbonyl towards the desired stereoisomer. This substitution thus allows obtaining a considerable increase of the yields in this step, and consequently allows significantly increasing the overall yield of the entire tapentadol synthesis process.2013-07-11
20130178645Method for Producing Carbonyl Compund - A method for producing a carbonyl compound of the present invention comprises a step (X) of reacting a specific compound having a urea bond with a carbonic acid derivative having a carbonyl group (—C(═O)—) under heating at a temperature equal to or higher than the thermal dissociation temperature of the urea bond to obtain the carbonyl compound.2013-07-11
20130178646NOVEL COMPOSITIONS AND METHODS - Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders.2013-07-11
20130178647Mixed Oxide Catalyst and a Process for the Production of Ethylenically Unsaturated Carboxylic Acids or Esters - The invention relates to a catalyst for the reaction of formaldehyde with a carboxylic acid or ester to produce an ethylenically unsaturated carboxylic acid or ester, preferably α, β ethylenically unsaturated carboxylic acids or ester. The catalyst includes a metal oxide having at least two types of metal cations, M2013-07-11
20130178648DERIVATIVES OF NOVEL PEROXIDES, METHOD OF PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AS WELL AS IN COSMETICS FOR THE TREATMENT OR PREVENTION OF ACNE - Compounds of the following general formula (I):2013-07-11
20130178649SULFONIC ACID GROUP-CONTAINING DIAMINE COMPOUND AND METHOD FOR PRODUCING THE SAME - The present invention provides a novel sulfonic acid group-containing diamine compound represented by formula (1) below, and a method for producing the same. This compound has a fluorene skeleton with sulfonic acid groups or derivatives thereof. In this compound, a substituent having an amino group is bonded to each of carbon atoms at the 2-position and the 7-position in the skeleton, and no substituent is bonded to a carbon atom at the 9-position in the skeleton. A in formula (1) denotes an optionally-substituted divalent aliphatic group (having a carbon number of 10 or less) or an optionally-substituted divalent aromatic group (having the number of rings of 4 or less), for example.2013-07-11
20130178650HYDROGEN TREATMENT OF IMPURE TALL OIL FOR THE PRODUCTION OF AROMATIC MONOMERS - A method of manufacturing aromatic hydrocarbons, which are suitable for the production of terephthalic acid, from tall oil-based raw material. According to the invention, the raw material that contains tall oil or its fraction is catalytically deoxygenated with hydrogen, and one or more aromatic hydrocarbons that can be converted into terephthalic acid are separated from the deoxygenated reaction yield. The deoxygenation catalyst is a NiMo catalyst and, in addition, a cracking catalyst can be used, such as an acidic zeolite catalyst. The separated hydrocarbon can be p-xylene, o-xylene or p-cymene. According to the invention, these can be converted by oxidation and, when needed, by a re-arrangement reaction into terephthalic acid that is suitable for the source material of the manufacture of bio-based polyethylene terephthalate.2013-07-11
20130178651PREPARATION METHOD OF HIGH-OPTICAL PURITY N2-[1-(S)-ETHOXYCARBONYL-3-PHENYLPROPYL]-N6-TRIFLUOROACETYL-L-LYSINE - Disclosed is a preparation method of high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine. The method includes: adding crude N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine to one or more organic solvents, and then reacting with an organic acid to form a salt, which is precipitated, thereby achieving the purpose of separation and purification; next, adding the obtained solid or mother concentrate into deionized water, and then adding an inorganic base or an organic base for basification, so as to adjust the pH value, removing the organic acid, filtering, washing and drying, to obtain the high-optical purity N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine, where the molar ratio of 1S-isomer to 1R-isomer is equal to or greater than 99:1.2013-07-11
20130178652METHOD OF INHIBITING POLYMERIZATION AND FOULING IN ACRYLIC ACID AND ACRYLATE PROCESSES - The method of inhibiting the polymerization of a mono-ethylenically unsaturated carboxylic acid, anhydride, ester or neutralized or partially neutralized salt, e.g., an acrylic acid or ester, in an aqueous solution and in the presence of oxygen, the method comprising the step of mixing with the aqueous solution an inhibitor comprising (i) at least 50 ppm of an N-oxyl compound, e.g., 4-hydroxy-TEMPO, and (ii) a manganese ion, the N-oxyl compound and manganese ion present in a N-oxyl compound to manganese ion weight ratio of 50:1 to less than 100:1. based on the mono-ethylenically unsaturated carboxylic acid, anhydride, ester or salt.2013-07-11
20130178653NOVEL PRECURSOR OF RADIOLABELLED CHOLINE ANALOG COMPOUNDS - The present invention describes intermediate(s), pre-cursor(s), for the preparation of radialabelled choline analogs to be used as radiotracers for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of diseases.2013-07-11
20130178654PROCESS FOR CINACALCET HYDROCHLORIDE - 3-[3-(Trifluoromethyl)phenyl]propionaldehyde is a key intermediate for the preparation of cinacalcet hydrochloride. The present invention provides a novel process for the preparation of 3-[3-(trifluoromethyl)phenyl]propionaldehyde. The present invention also provides an improved process for preparation of cinacalcet hydrochloride in high yields. The present invention further provides a process for purification of cinacalcet hydrochloride.2013-07-11
20130178655METHOD FOR SYNTHESIZING 3,5-DICHLOROANISOLE FROM 1,3,5-TRICHLOROBENZENE - The invention relates to a method for synthesizing 3,5-dichloroanisole from 1,3,5-trichlorobenzene, which comprises:2013-07-11
20130178656PROCESS FOR PREPARING SECONDARY AMINES IN THE LIQUID PHASE - The present application relates to a process for preparing secondary amines by aminating excess primary or secondary alcohols with primary amines in the liquid phase in the presence of copper-comprising catalysts.2013-07-11
20130178657ENERGY EFFICIENT SYNTHESIS OF ALIPHATIC ALDEHYDES FROM ALKENES AND CARBON DIOXIDE - The problem addressed by the present invention is that of specifying a process for producing aldehydes which, compared with conventional hydroformylation, cuts CO2013-07-11
20130178658NOVEL DIVINYL-ETHER COMPOUND AND MANUFACTURING METHOD THEREFOR - A novel divinyl ether compound having the formula (I):2013-07-11
20130178659NOVEL FLUORINE-CONTAINING VINYL ETHER COMPOUND AND METHOD FOR PRODUCING THE SAME - A fluorine-containing vinyl ether compound of the formula: C2013-07-11
20130178660CRYSTALLIZER AND METHOD FOR PRODUCING PHENOL-BPA ADDUCT CRYSTALS - A method for the evaporative production of phenol-BPA adduct crystals in a crystallizer is provided. First, a supersaturated BPA solution is introduced into a crystallizer that includes a cylindrical vessel and a concentrically-disposed draft tube that defines an annular space between the vessel and tube. Next, the BPA solution is circulated through the draft tube and annular space while a coolant is uniformly distributed in the circulating flow by radially injecting a volatile hydrocarbon compound at between about 30% and 60% of a radial extent of the annular space of to form a BPA mixture. Phenol-BPA adduct crystals are produced in the vessel by evaporating the volatile hydrocarbon compound out of the BPA mixture. The method provides a consistent and uniform concentration of coolant across the surface of the boiling zone that prevents or at least reduces unwanted crystal nucleation.2013-07-11
20130178661Hydrogenation Catalysts with Cobalt-Modified Supports - The present invention relates to catalysts, to processes for making catalysts and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid to ethanol. The catalyst comprises a precious metal and one or more active metals on a modified support that comprises cobalt.2013-07-11
20130178662Modified Catalyst Supports - The present invention relates to modified catalyst supports, to processes for making modified catalyst supports, and to chemical processes employing catalysts that comprise such modified catalyst supports. The modified catalyst support comprises a first metal, a second metal and a support modifier on a support, wherein the support modifier comprises a support modifier metal selected from the group consisting of tungsten, molybdenum, vanadium, niobium, and tantalum.2013-07-11
20130178663COBALT-CONTAINING HYDROGENATION CATALYSTS AND PROCESSES FOR MAKING SAME - The present invention relates to catalysts, to processes for making catalysts and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid to ethanol. The catalyst comprises cobalt, precious metal and one or more active metals on a modified support.2013-07-11
20130178664Hydrogenation Catalysts - The present invention relates to catalysts, to processes for making catalysts and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid to ethanol. The catalyst comprises a precious metal and one or more active metals on a modified support. The modified support may comprise cobalt tungstate.2013-07-11
20130178665Processes For Making Catalysts With Acidic Precursors - The present invention relates to catalysts, to processes for making catalysts with acidic precursors and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid to ethanol. The catalyst comprises a precious metal and one or more active metals on a support, optionally a modified support.2013-07-11
20130178666Processes for Making Catalysts With Metal Halide Precursors - The present invention relates to catalysts, to processes for making catalysts with halide containing precursors and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid to ethanol. The catalyst comprises a precious metal and one or more active metals on a support, optionally a modified support.2013-07-11
20130178667Processes for Making Catalysts - The present invention relates to catalysts, to processes for making catalysts and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid to ethanol. The catalyst comprises a precious metal and one or more active metals on a support, optionally a modified support.2013-07-11
20130178668Multifunctional Hydrogenation Catalysts - The present invention relates to catalysts, to processes for making catalysts and to chemical processes employing such catalysts. The multifunctional catalysts are preferably used for converting acetic acid and ethyl acetate to ethanol. The catalyst is effective for providing an acetic acid conversion greater than 20% and an ethyl acetate conversion greater than 0%. The catalyst comprises a precious metal and one or more active metals on a modified support. The modified support includes a metal selected from the group consisting of tungsten, vanadium, and tantalum, provided that the modified support does not contain phosphorous.2013-07-11
20130178669Cobalt and Tin Hydrogenation Catalysts - The present invention relates to catalysts, to processes for making catalysts and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid and ethyl acetate to ethanol. The catalyst comprises a precious metal, tin and cobalt, wherein molar ratio of cobalt to tin is at least 11:1.2013-07-11
20130178670HYDROGENATION CATALYSTS WITH BULK MULTIPLE OXIDATED SUPPORTS - The present invention relates to catalysts, to processes for making catalysts and to chemical processes employing such catalysts. The catalysts are preferably used for converting acetic acid and ethyl acetate to ethanol. The catalyst comprises an extruded modified support, and a precious metal. The processes for making the catalysts comprises modifying the catalyst, extruding the catalyst, and impregnating the precious metal onto the catalyst.2013-07-11
20130178671PRODUCTION OF ETHANOL FROM SYNTHESIS GAS - A process for producing ethanol from synthesis gas by reacting the hydrogen and carbon monoxide of the synthesis gas to provide methanol, which then is subjected to dehydration to produce at least one ether, such as dimethyl ether. The ether, such as dimethyl ether, then is subjected to carbonylation with unreacted carbon monoxide from the synthesis gas to provide at least one acetate, such as methyl acetate. The acetate then is subjected to hydrogenolysis to produce ethanol.2013-07-11
20130178672PROCESS FOR MAKING A DISTILLATE PRODUCT AND/OR C2-C4 OLEFINS - A process for making a distillate product and one or more C2-C4 olefins from a FCC feedstock containing a cellulosic material and a hydrocarbon co-feed is provided.2013-07-11
20130178673METHOD OF PRODUCING VALUABLE AROMATICS AND OLEFINS FROM HYDROCARBONACEOUS OILS DERIVED FROM COAL OR WOOD - This invention relates to a method of producing aromatics and olefins from oils derived from coal or wood, including partially saturating and cracking the oils derived from coal or wood in a hydrogenation & reaction area, separating them depending on the number of carbons, recirculating heavy oils having 11 or more carbons to the hydrogenation & reaction area, feeding oils suitable for producing BTX to an aromatic separation process and a transalkylation process to recover aromatics, and feeding hydrocarbonaceous components having 5 or less carbons to a light separation process, thus obtaining olefins.2013-07-11
20130178674REACTOR AND PROCESS FOR DEHYDRATION OF ETHANOL TO ETHYLENE - A reactor design and configuration and a process for the catalytic dehydration of ethanol to ethylene where the reactor train is comprised of a multi-stage single reactor vessel or multiple reactor vessels wherein each stage and/or vessel has different length, internal diameter, and volume than the other stages and/or vessels and in addition the stages and/or reactor vessels are connected in series or in parallel arrangement, preferably used with an improved means of introducing the ethanol feedstock and a heat carrying inert gas to the improved reactor train.2013-07-11
20130178675Vaporization of Liquid Halogen by Contact with a Preheated Gas - A method is provided for vaporizing a liquid elemental halogen. A heating gas is preheated in the absence of halogen to a preheat temperature which results in a preheated heating gas. The preheated heating gas is directly contacted with a feed of a liquid elemental halogen and heats the feed to a vaporizing temperature sufficient to vaporize at least a portion of the feed to a quantity of an elemental halogen vapor. A gas mixture results which includes the heating gas and the quantity of the elemental halogen vapor.2013-07-11
20130178676METHODS FOR PRODUCING LIGHT OLEFINS - Methods for producing light olefins are provided. An exemplary method includes providing an oxygenate compound capable of converting to light olefins in a catalytic reaction or to a clean reaction intermediate compound of the catalytic reaction and converting the oxygenate compound to the clean reaction intermediate compound in a chemical reaction. The chemical reaction produces a gas-phase product comprising the clean reaction intermediate compound, unconverted oxygenate, and a reaction byproduct. The method further includes cooling the gas-phase product to condense unconverted oxygenate and reaction byproduct while maintaining the clean reaction intermediate compound in a gas phase and separating the clean reaction intermediate compound, the unconverted oxygenate, and the reaction byproduct into a first stream including the clean reaction intermediate compound and a second stream including the unconverted oxygenate and the reaction byproduct. Still further, the method includes contacting the first stream with a catalyst configured for producing light olefins.2013-07-11
20130178677METHOD AND A SYSTEM FOR CONVERTING CARBON DIOXIDE INTO CHEMICAL STARTING MATERIALS - A method and apparatus convert carbon dioxide into chemical starting materials. Carbon dioxide is isolated from flue gas emitted by a combustion system. An electropositive metal is burned in an atmosphere of isolated carbon dioxide to reduce the carbon dioxide into chemical starting materials.2013-07-11
20130178678METHOD FOR CONTROLLING 2-PHENYL ISOMER CONTENT OF LINEAR ALKYLBENZENE AND CATALYST USED IN THE METHOD - A method for controlling 2-isomer content in linear alkylbenzene obtained by alkylating benzene with olefins and catalyst used in the method.2013-07-11
20130178679PROCESS FOR CONTINUOUSLY PREPARING POLYISOBUTYLENE - Continuous preparation of polyisobutylene having a content of terminal double bonds of more than 50% by polymerizing isobutene in the presence of a polymerization catalyst customary therefor, by combining a technical 1-butene-, 2-butene- and isobutene-containing C2013-07-11
20130178680CATALYST FOR OXIDATIVE COUPLING OF METHANE, METHOD FOR PREPARING THE SAME, AND METHOD FOR OXIDATIVE COUPLING REACTION OF METHANE USING THE SAME - The present disclosure relates to a catalyst for oxidative coupling of methane, specifically, it relates to a catalyst for oxidative coupling of methane comprising: a magnesium titanium oxide support comprising a mixed oxide of magnesium and titanium; and sodium tungstate and manganese oxide supported on the support, a method for preparing the same, and a method for oxidative coupling of methane. The catalyst for oxidative coupling according to the present disclosure, wherein a mixed oxide of magnesium and titanium is used as the support of the catalyst, is capable of providing significantly improved catalytic activity and C2013-07-11
20130178681START-UP METHOD FOR REACTION-REGENERATION UNIT USED TO PREPARE LIGHT OLEFINS FROM METHANOL - The invention provides a start-up method for a reaction-regeneration unit for preparing light olefins from methanol, which comprises: (a) heating a regenerator with an auxiliary combustion chamber and a reactor with a start-up furnace; (b) charging a catalyst into the regenerator and reactor; (c) closing a spent catalyst slide valve and a regenerated catalyst slide valve after the reactor reaches about 350° C. or more; (d) feeding methanol to the reactor after the dense phase stage of the regenerator reaches about 350° C. or more; (e) opening the spent catalyst slide valve and introducing a carbon deposited catalyst from the reactor to the regenerator after the dense phase stage reaches about 400° C. or more and the average amount of carbon deposits on the catalyst in the reactor reaches about 2.5% or more; (f) raising the regenerator to above about 580° C.; and (g) stopping the start-up furnace and auxiliary combustion chamber.2013-07-11
20130178682NON-OXIDATIVE DEHYDROGENATIVE PROCESS - Use a supported catalyst that includes a catalyst support and a combination of nickel, gallium, and, optionally, one or more of an alkali metal, an alkaline earth metal and a lanthanide to effect non-oxidative dehydrogenation of an oxygen-free gaseous stream that comprises an alkane such as ethane, propane or butane to a product stream that comprises a corresponding alkene such as propylene where the alkane is propane.2013-07-11
20130178683PROCESS FOR REMOVING OXYGENATED CONTAMINANTS FROM AN HYDROCARBONSTREAM - The present invention is a process for removing oxygenated contaminants and water from an hydrocarbon stream comprising: 2013-07-11
20130178684PROCESS FOR PROVIDING A VAPOROUS PURIFIED CRUDE C4 CUT AS A FEED STREAM FOR AN EXTRACTIVE DISTILLATION WITH A SELECTIVE SOLVENT - Mixtures of hydrocarbons predominantly having 4 carbon atoms per molecule known as C2013-07-11
20130178685APPARATUS AND METHOD FOR THE GRANULATION OF RADIOACTIVE WASTE, AND VITRIFICATION METHOD THEREOF - An apparatus and method for the granulation of radioactive waste in which a preprocessing method for the vitrification of radioactive waste is simplified to conform to onsite conditions of a nuclear power plant, additives are improved, and pellets suitable for vitrification are manufactured. The apparatus for the granulation of radioactive waste includes: a body frame having an inlet and an outlet; a hopper supplying the radioactive waste to be transferred and fed through the inlet; a feeder transferring/supplying the radioactive waste supplied to a specific position and in a certain quantity; a stirrer pulverizing/mixing lumps of the radioactive waste supplied; an additive supply part supplying a lubricant to the radioactive waste fed into the stirrer; and a pellet press pressing the radioactive waste fed through the feeder into a pellet shape and discharging the pellet through the outlet.2013-07-11
20130178686METHOD AND DEVICE FOR LIMITING THE DEGASSING OF TRITIATED WASTE ISSUED FROM THE NUCLEAR INDUSTRY - A method and device for limiting the degassing of tritiated waste issued from the nuclear industry are provided. The method reduces an amount of generated tritiated hydrogen (T2013-07-11
20130178687TISSUE DIGESTION METHOD AND APPARATUS - Tissue digestion methods and apparatuses that provide easy, safe and inexpensive disposal of biological tissue, for example animal carcasses and human cadavers, are disclosed. Embodiments include tissue digesters with elongated cylindrical vessels for holding digestive fluid and baskets for holding tissue within said vessel. Embodiments include baskets with perforations to allow circulation of digestive fluid around and about the tissue. In one form the basket holding the tissue is horizontally loaded into a horizontally disposed vessel. The vessel is then tilted to a more vertical orientation. Gravity helps to collect the tissue fragments in a sloped collection region of the basket, which is located near a mixer to allow continual agitation of the tissue fragments as they are digested. The tissue digester can operate efficiently at lower temperature and pressures, is mechanically less complicated, consumes less power and is less expensive to manufacture than conventional tissue digesting systems. At higher temperatures employed in a pressure vessel provided by this invention, the tilting mechanism also dramatically improves the efficiency of the process and the completeness of the tissue digestion.2013-07-11
20130178688SEQUENCING SECTOR FIELDS - A method for planning a treatment session of a patient and optimizing the treatment time for a treatment using a radiation therapy system includes a radiation therapy unit having a fixed radiation focus point. During an optimization of a treatment plan for a patient, a set of shots to be delivered to a plurality of isocenter positions within a target volume of a patient during a treatment session are determined and a beam-on time for each respective sector and state for each isocenter during which radiation is to be delivered are determined based on the treatment plan. For each isocenter position, sectors and states of respective sector are grouped in accordance predetermined rules with respect to beam-on times for respective state of the sectors, wherein sectors and respective states are aggregated for simultaneous delivery of radiation during a predetermined period of time.2013-07-11
20130178689TARGETS FOR GENERATING IONS AND TREATMENT APPARATUSES USING THE TARGETS - Provided is an ion beam treatment apparatus including the target. The ion beam treatment apparatus includes a substrate having a first surface and a second surface opposed to the first surface, and including a cone type hole decreasing in width from the first surface to the second surface to pass through the substrate, wherein an inner wall of the substrate defining the cone type hole is formed of a metal, an ion generation thin film attached to the second surface to generate ions by a laser beam incident into the cone type hole through the first surface and strengthen, and a laser that emits a laser beam to generate ions from the ion generation thin film and project the ions onto a tumor portion of a patient. The laser beam incident into the cone type hole is focused by the cone type hole and is strengthened.2013-07-11
20130178690RADIOTHERAPY APPARATUS CONTROLLER AND RADIOTHERAPY APPARATUS CONTROL METHOD - A radiotherapy apparatus control method includes: collecting a planning-stage position where a patient is arranged during a planning stage; collecting a position-adjusting-stage position where the patient is arranged during a position-adjusting stage; calculating a treatment-stage position, a gantry-angle offset value and a ring-angle offset value such that an orientation in which an irradiation head is arranged with respect to the treatment-stage position, when a ring is arranged while deviating from a ring angle by the ring-angle offset value and a gantry is arranged while deviating from a gantry angle by the gantry-angle offset value, coincides with an orientation in which the irradiation head is arranged with respect to the planning-stage position, when the ring is arranged at the ring angle and the gantry is arranged at the gantry angle. After that, the patient is arranged at a patient position.2013-07-11
20130178691Electrically lossy magnetic liquid composition for controlled tissue heating - A dental floss apparatus comprised of a pair of handles that are configured for engagement with the fingers with strands of flossing substrate extending therebetween. The flossing substrates are spaced from each other, running substantially parallel and extending within an opening formed between the ends of the handles. A dissolvable substrate is positioned within this opening through an engagement with one or both of the handles or the flossing substrate, and upon contact with the surface of the teeth, dissolves, and deposits a residue on the surface of the teeth and the surrounding area of the mouth. The dissolvable substrate may be formed of two substrate pieces with a central gap between them defining a means for targeting insertion of the substrate between adjacent teeth and may be colorized or luminescent and have an additive material such as mouthwash, breath freshener, cooling agent, or flavor.2013-07-11
20130178692TRANSCRANIAL MAGNETIC STIMULATION SYSTEM AND METHODS - A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.2013-07-11
20130178693METHOD AND SYSTEM FOR COMBINING ANATOMICAL CONNECTIVITY PATTERNS AND NAVIGATED BRAIN STIMULATION - When operating a brain stimulation device, it is critical to understand and control the network effects associated with the area being targeted for stimulation. The combined system and methods provided herein provides the operator with a real-time view of the brain network potentially affected by the stimulation. The system and method are capable of increasing the accuracy of diagnostic information. Additionally, disclosed herein are a system and method for combining navigated brain stimulation data and anatomical data with brain connectivity data for an individual.2013-07-11
20130178694APICAL RING FOR VENTRICULAR ASSIST DEVICE - An apical ring for coupling a conduit of a ventricular assist device to a heart has an annular disk with a central aperture for receiving the conduit. A collar is axially aligned with the central aperture and has a cylindrical shape interrupted by a gap between first and second ends of the collar. The collar has a fixed section joined to the annular disk and has a cantilever section extending from the fixed section to the first end of the collar. A tightener selectively drives the first end toward the second end to close the gap in order to retain the conduit within the collar. The cantilever section includes a relief slot that is expandable for extending a circumferential length of the cantilever section in response to interacting with the conduit when the gap is closed.2013-07-11
20130178695HARMONIOUS SCALE INSTRUMENT - The present invention relates to a musical instrument for producing a harmonious scale of musical notes. The instrument includes nine separate sound actuators each of which is configured to cause the musical instrument to generate a different frequency selected from the group of frequencies comprising 174 Hz, 285 Hz, 396 Hz, 417 Hz, 528 Hz, 639 Hz, 741 Hz, 852 Hz and 963 Hz, the musical instrument being configured such that physically manipulating the sound actuators causes the musical instrument to generate the frequency corresponding to the sound actuator manipulated. The invention is also directed at a system for—writing music to be played with a musical instrument incorporating the harmonious scale of musical notes as described above. The notation system includes a staff of five parallel and horizontal lines separated by four spaces, the first line indicating a first note of 174 Hz, the space immediately above the first line indicating a second note of 285 Hz, the second line indicating a third note of 396 Hz, the space immediately above the second line indicating a fourth note of 417 Hz, the third line indicating a fifth note of 528 Hz, the space immediately above the third line indicating a sixth note of 639 Hz, the fourth line indicating a seventh note of 741 Hz, the space immediately above the fourth line indicating an eighth of 852 Hz and the fifth line, indicating a ninth note of 963 Hz.2013-07-11
20130178696BODILY IMPLANTS FORMED FROM DIFFERENT MATERIALS - In one embodiment, an implant includes a body member and an extension member. The body member is formed of a first material and has a first side portion and a second side portion. The extension member is formed of a second material different than the first material. The extension member has a first arm portion, a second arm portion, and a mid-portion disposed between the first arm portion and the second arm portion. The mid-portion extends from the first side portion of the body member to the second side portion of the body member. The first arm portion extends from the first side portion of the body member along a first axis. The second arm portion extends from the second side portion of the body member along a second axis different than the first axis.2013-07-11
20130178697SMOOTH SURFACE GASTRIC BAND DEVICE AND SYSTEM - A gastric band that includes a band portion having securing system that secures the gastric band in a closed position, and an inflatable portion associated with the band portion that includes a stomach contacting wall. The tissue contacting wall includes an exterior surface and an interior surface that includes at least one relief area that defines a pillow portion in the tissue contacting wall.2013-07-11
20130178698METHODS, INSTRUMENTS AND DEVICES FOR EXTRAGASTIC REDUCTION OF STOMACH VOLUME - Methods, instruments and systems are provided for separating opposite walls of the stomach by extragastric application of suction. Plication of the stomach can be performed between the separated walls after which the separate walls are brought back toward one another. In another aspect, methods, instruments, devices and systems are provided for reducing the effective volume of a stomach by performing one or more extragastric plications of the stomach.2013-07-11
20130178699MINIMALLY INVASIVE TISSUE SUPPORT - Described are methods and apparatus for use in supporting tissue in a patient's body. In some embodiments, the patient's breast is supported. In some embodiments, the methods provide ways of supporting and adjusting tissue, and the apparatus includes components and embodiments for supporting and adjusting the tissue. Some embodiments include a supporting device, having a first portion, a second portion, and a support member positioned between the first portion and second portion. Some embodiments include advancing the first portion of the supporting device into the body to a first location in the body; advancing the second portion of the supporting device into the body to a second location in the body; securing the first portion of the supporting device at the first location; and shifting soft tissue in the body with the support member.2013-07-11
20130178700IN-VIVO INFORMATION ACQUIRING APPARATUS AND IN-VIVO INFORMATION ACQUIRING METHOD - A capsule endoscope includes a plurality of function executing sections and which acquire information inside a body of a subject, a battery which supplies power to the plurality of function executing sections, a switching section having a plurality of switches which independently control power supply from the battery to the respective function executing sections, a magnetic field sensing section which receives a control signal from outside the subject, and a power control section which controls the switching section according to the number of times the control signal is received by the magnetic field sensing section.2013-07-11
20130178701Integrated Delivery and Visualization Tool for a Neuromodulation System - Methods and apparatus for delivering a neurostimulator to a target tissue are provided which may include any number of features. One feature is a delivery tool comprising a handle portion, an elongate shaft comprising a contoured distal portion, a visualization system embedded in the elongate shaft, and an insertion groove on the elongate shaft configured to deploy the neurostimulator. The contoured distal portion can be shaped and configured to maintain contact with a posterior maxilla and elevate a periosteum off of the posterior maxilla to avoid soft tissue dissection. In some embodiments, the neurostimulator is implanted in close proximity to or touching the sphenopalatine ganglion.2013-07-11
20130178702ANTENNA APPARATUS, ANTENNA, ANTENNA HOLDER, AND BODY-INSERTABLE APPARATUS SYSTEM - An antenna apparatus is configured to acquire information from a body-insertable apparatus that is configured to be inserted into a subject to move inside the subject. The antenna apparatus includes an antenna that includes one sheet on which plural receiving antennas are fixed and in which a first positioning hole is formed; and an antenna holder that includes a container portion which is configured to hold the antenna at a predetermined position and in a predetermined orientation and in which second positioning hole is formed at a position corresponding to the first positioning hole when the antenna is held. The antenna holder is configured to be attached to a predetermined position of the subject using the first and second positioning holes as an index when the antenna is held in the antenna holder.2013-07-11
20130178703Endoscope Shaft With Malleable Section - An endoscope including a control section; and a shaft extending from the control section. The shaft includes a malleable section and a distal active deflection section. The shaft includes a frame and at least one active deflection control wire extending through the malleable section between the control section and the distal active deflection section. The frame includes a malleable frame member at the malleable section. The malleable frame member connects a frame member of the frame at the distal active deflection section to the control section.2013-07-11
20130178704Scope Tubes, Intubation Assemblies, and Methods of Intubation - A scope tube may include an elongated member, a lever, a coupling member, and a handle portion. The elongated member may define a through bore tapering from a proximal end of the elongated member toward a distal end of the elongated member. The lever may be pivotally coupled to the elongated member, and the coupling member may be pivotally coupled with the lever and may extend beyond the proximal end of the elongated member. The handle portion may be fixedly coupled with the elongated tube distal of the lever. The handle portion may be proximate the lever such that a user can grasp the handle portion with one hand and operate the lever with the thumb of the same hand.2013-07-11
20130178705ENDOSCOPE - An endoscope includes an insertion section, a bending section, a bending operation section and a shift mechanism. The bending section includes a first bending section and a second bending section provided at a proximal end of the first bending section. The second bending section includes an actuation pipe interposed between an angle wire extending in the second bending section and a wire guide through the angle wire and guiding the angle wire, and supported to be moved in the extending direction of the wire guide with respect to the wire guide. A rigidity of the second bending section is shifted while the actuation pipe is moved in the extending direction of the wire guide.2013-07-11
20130178706SCANNING ENDOSCOPE APPARATUS - A scanning endoscope apparatus includes: a light source; first and second polarization sections; third and fourth polarization sections; a first wavelength separation section; a second wavelength separation section; a first detection section; and a second detection section. The scanning endoscope apparatus further includes: a first judgment section comparing light intensities of at least two of the light having a first wavelength band transmitted through the first wavelength separation section, the light having a second wavelength band transmitted through the first wavelength separation section, the light having the first wavelength band transmitted through the second wavelength separation section and the light having the second wavelength band transmitted through the second wavelength separation section to observe the return light on a surface area; and a second judgment section comparing light intensities of two which are not used by the first judgment section to observe the return light in a deep-part area of the subject.2013-07-11
20130178707MEDICAL DEVICE - A device forming a combination ophthalmoscope and otoscope, having a housing (2013-07-11
20130178708Articulating Method Including A Pre-Bent Tube - A surgical device is provided including an access port having a tubular member with a first ring secured at a proximal end and a second ring secured at a distal end; an articulation structure having an outer tube and an inner tube; and a control mechanism coupled to one end of the inner tube for advancing the inner tube through the outer tube; wherein the outer tube includes at least one rigid section and at least one flexible section and the inner tube includes at least two pre-bent sections.2013-07-11
20130178709METHODS FOR THE PREVENTION OF SURGICAL SITE INFECTIONS - Several methods to reduce surgical site infections include inserting a surgical access device into an incision, retracting tissue, and introducing fluid into the surgical access device such that the fluid exits the surgical access device and irrigates a surgical site. Other methods do not include introducing fluid into a surgical access device but include suctioning a fluid into the surgical access device and removing the fluid from the body.2013-07-11
20130178710SYSTEMS FOR THE PREVENTION OF SURGICAL SITE INFECTIONS - A surgical access system facilitates access to a surgical site within a patient's body through an incision in the body. Surgical access systems can have at least one retention member and a fluid transportation member configured to deliver fluid to a surgical site or to remove fluid from a surgical site. In some embodiments, a surgical access device irrigates a surgical site to reduce surgical site infections and removes fluid from the surgical site to increase a physician's visibility into the surgical site.2013-07-11
20130178711DEVICES AND METHODS FOR ENDOVASCULAR ACCESS AND THERAPY - The present invention provides for devices and methods for providing endovascular therapy, including facilitating establishment of vascular access, placement of endovascular sheaths, catheter tip localization, and administration of vascular occlusion. The inventions includes a vessel cannulation device, an expandable sheath, an occlusion catheter, and a localizer each of which may be provided separately or used as part of a system.2013-07-11
20130178712Triangulation Methods with Hollow Segments - A surgical apparatus providing access to an underlying body cavity through a tissue tract articulates a flexible surgical object inserted therein. The surgical apparatus includes a tube member defining a longitudinal axis and a lumen therethrough to receive the flexible surgical object. The tube member includes a proximal member, a middle member connected to the proximal member at a first joint, and a distal member connected to the middle member at a second joint. The surgical apparatus also includes articulation mechanisms to articulate the tube member.2013-07-11
20130178713Articulation Control Mechanisms - A surgical access port and method for achieving articulation is disclosed, the surgical access port including a housing, at least one lumen extending through the housing, and an articulation structure. The housing comprises an access member having a proximal end and a distal end, and defines a longitudinal axis. The lumen in the housing extends from the proximal to the distal end of the access member along the longitudinal axis. The articulation structure comprises a first tubular member and a second tubular member, the second tubular member hingably attached to the first tubular member, and an articulation element slidably attached to the first tubular member.2013-07-11
20130178714SURGICAL TONGUE DEPRESSOR - The present invention relates to a tongue depressor with a light. The present invention relates to a tongue depressor designed to be utilized when the clinician is positioned behind the head of the patient, for example, during anesthesia in surgery where insertion or removal of an airway device into the patient is necessary. The depressor comprises an anatomical bend, gripping surface for holding the depressor, a tissue grabbing surface, and a barrel end at the distal end of the grabbing and moving tissue, such as the tongue.2013-07-11
20130178715PRESENT-ON-BED DETERMINATION APPARATUS AND SLEEP MEASUREMENT APPARATUS - A present-on-bed determination apparatus includes: a sensor unit usable with a bottom bedding and configured to measure biological displacement of a human subject on the bottom bedding so as to output a measurement signal showing a measurement result; a first signal processing unit configured to amplify the measurement signal with a first gain so as to output a first output signal; a first A/D conversion unit configured to output a plurality of first level values obtained by A/D conversion of the first output signal; and a determination unit configured to determine whether or not the human subject is present on the bottom bedding in accordance with a dispersion indicator that indicates dispersion degree of the plurality of the first level values.2013-07-11
20130178716DEVICE FOR APPLYING A PNEUMATIC PRESSURE STIMULUS IN THE NASAL FOSSAE AND EUSTACHIAN TUBE AT THE TIME OF DEGLUTITION - Apparatus for automatically applying a pneumatic overpressure phase, of a value of between 5 and 100 hPa in the Eustachian tube and/or in the nasal fossae of a patient through at least one nostril at the moment of swallowing, includes a gas generator, a gas reservoir, a detection-fluid and control circuit communicating with the gas reservoir and gas generator and leading to a sealed plug in the nostrils forming part of a nosepiece equipped with a control nozzle, a device for measuring at least one characteristic value of a flow of gas during swallowing, a device for automatically comparing the characteristic value with at least one pre-set value, and a device for informing the patient whether the swallowing action is being correctly performed.2013-07-11
20130178717DEVICE AND METHOD FOR DETERMINING A FERTILE PHASE OF A WOMAN BY ASCERTAINING A CO2 PARTIAL PRESSURE IN A RESPIRATORY GAS OF THE WOMAN - The invention relates to a device (2013-07-11
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