27th week of 2022 patent applcation highlights part 10 |
Patent application number | Title | Published |
20220211865 | REDUCTION OF APPLICATION-RELATED SIDE REACTION OF A THERAPEUTIC ANTIBODY - The present invention relates to anti-brain target agents and therapeutic uses thereof. | 2022-07-07 |
20220211866 | MOMP TELONANOPARTICLES, AND RELATED COMPOSITIONS, METHODS AND SYSTEMS - A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a | 2022-07-07 |
20220211867 | NANOPARTICLE FOR SPECIFICALLY HYDROLYZING TEMPLATE PROTEIN MOLECULE, AND PREPARATION AND APPLICATION THEREOF - Disclosed are a nanoparticle for specifically hydrolyzing a template protein molecule, and a preparation and application thereof. The nanoparticle includes a nanozyme as a core and a template protein-imprinted polymer as a shell The nanoparticle can be used in the preparation of drugs for treating cytokine release syndrome. | 2022-07-07 |
20220211868 | NANOPARTICLES COMPRISING NON-CLASSICAL MHC AND USES THEREOF - Described herein are non-classical MHC-nanoparticle complexes that expand invariant NKT cells. Expansion of invariant NKT cells are useful in the treatment of autoimmune or inflammatory disorders | 2022-07-07 |
20220211869 | PHENYLALANINE FUNCTIONALISED MESOPOROUS SILICA NANOPARTICLES AS DRUG-FREE NANOTHERAPEUTICS OR BIOACTIVE NANOCARRIER FOR ANTI-CANCER APPLICATIONS - The present invention provides an amino acid-functionalized nanoparticle, comprising: a nanoparticle having a dimension in the range of units of nanometers to 100 nanometers, and having an external surface; and a plurality of amino acid molecules conjugated to the external surface of the nanoparticle, the amino acid molecules having a chemical property that can induce a cancer cell to ingest the functionalized nanoparticle; a method of producing such a nanoparticle; and uses of the nanoparticle. | 2022-07-07 |
20220211870 | PACLITAXEL-ALBUMIN-BINDING AGENT COMPOSITIONS AND METHODS FOR USING AND MAKING THE SAME - Described herein are nanoparticle compositions comprising binding agents, carrier proteins and an, amount of paclitaxel derivative, and optionally a therapeutic agent. Also described herein are nanoparticle compositions comprising carrier proteins and an amount of paclitaxel, and optionally binding agents and/or a therapeutic agent, wherein the paclitaxel is present in an amount that is less than an amount that provides a therapeutic effect. Also disclosed herein are nanoparticles which contain (a) carrier protein, (b) a paclitaxel derivative, the paclitaxel derivative haying reduced toxicity compared to paclitaxel, and optionally (c) a binding agent and/or (d) a therapeutic agent. Also described are methods of making and using the same, in particular, as a cancer therapeutic. | 2022-07-07 |
20220211871 | GENE THERAPIES FOR LYSOSOMAL DISORDERS - The disclosure relates, in some aspects, to compositions and methods for treatment of central nervous system (CNS) diseases, for example Parkinson's disease (PD) and Gaucher disease. In some embodiments, the disclosure provides expression constructs comprising a transgene encoding one or more CNS disease-associated gene products and/or one or more an inhibitory nucleic acids targeting a CNS disease-associated gene or gene product. In some embodiments, the disclosure provides methods of treating CNS diseases by administering such expression constructs to a subject in need thereof. | 2022-07-07 |
20220211872 | GENE THERAPY WITH THE GENES HOKD AND LDRB FOR CANCER TREATMENTS - The invention relates to the isolated RNA or DNA polynucleotides hokD and ldrB for use in medicine, particularly in gene therapy for cancer treatment. Also described are compositions comprising such polynucleotides or related genetic structures, and a method for treating proliferative disorders, preferably cancer. | 2022-07-07 |
20220211873 | TREATMENT OF PRIMARY CILIARY DYSKINESIA WITH SYNTHETIC MESSENGER RNA - Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5. | 2022-07-07 |
20220211874 | MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES - Materials and methods for treating a patient with a hemoglobinopathy, both ex vivo and in vivo, and materials and methods for deleting, modulating, or inactivating a transcriptional control sequence of a BCL11A gene in a cell by genome editing. | 2022-07-07 |
20220211875 | INTRANASAL ADMINISTRATION OF ADENO-ASSOCIATED VIRUS TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS - A method to prevent, inhibit or treat one or more symptoms associated with disease of the central nervous system by intranasally, intrathecally, intracerebrovascularly or intravenously | 2022-07-07 |
20220211876 | LESION DETECTION METHOD - Provided is a method for detecting a lesion characterized by administering to an organ a cell staining agent that enables observation of biological tissue by laser irradiation, and then irradiating the organ with multiphoton laser or confocal laser to image the inside of lesion in the organ, and determining the interface between normal site and lesion site. | 2022-07-07 |
20220211877 | COMPOUND FOR INTRAOPERATIVE MOLECULAR BIOIMAGING, METHOD OF MAKING THE SAME, USE THEREOF IN INTRAOPERATIVE MOLECULAR BIOIMAGING AND SURGICAL METHOD COMPRISING INTRAOPERATIVE MOLECULAR BIOIMAGING - The present invention provides compounds suitable for intraoperative bioimaging. In particular, compounds are provided that are suitable for marking tumor tissue during surgery to facilitate complete removal of said tumor tissue. Corresponding methods for intraoperative bioimaging and methods for surgery comprising intraoperative bioimaging are also provided. | 2022-07-07 |
20220211878 | CROSS-LINKED POLYMER MODIFIED NANOPARTICLES - Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease. | 2022-07-07 |
20220211879 | SOLVENT FREE GADOLINIUM CONTRAST AGENTS - Disclosed herein are complexes of gadolinium metal, ligand and meglumine that are substantially free of non-aqueous solvents. In particular, solvent-free complexes of 1) gadopentetate dimeglumine and 2) gadoterate meglumine are disclosed and methods of their preparation are disclosed. In addition, methods are disclosed for purifying reactants, monitoring and controlling pH, quantifying the free gadolinium content, quantifying the concentration of gadolinium-ligand complex in aqueous solution, and procedures for producing a drug product in one step. The one step process eliminates the need to dry the gadolinium-ligand complex, which is typically highly hygroscopic. The one step process includes purification steps that do not require the use of non-aqueous solvents. | 2022-07-07 |
20220211880 | IMAGING WITH LIPOSOME-BASED CONTRAST AGENTS BASED ON MODULATION OF MEMBRANE WATER PERMEABILITY - The present disclosure provides imaging and contrast agents, and methods of using the agents. According to some embodiments of the disclosure, agents and methods for magnetic resonance imaging and related technologies are provided. | 2022-07-07 |
20220211881 | COATED PLANT VIRUS IMAGING AGENTS - An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed. | 2022-07-07 |
20220211882 | METHOD AND DEVICE FOR PRODUCING OPTIMIZED LIPID-BASED MICRO/NANO-BUBBLES - A method of producing lipid-based micro/nano bubbles includes steps of (a) preparing a lipid mixture including one or more first lipids with different phase transition temperature, and a second lipid bonding with a hydrophilic polymer moiety or molecules capable of getting across a lipid membrane and decreasing van der Waals forces between lipid bilayers; (b) emulsifying the lipid mixture with a solvent, to form a transparent lipid carrier solution; (c) placing the transparent lipid carrier solution in a closed vessel with halo-substituted hydrocarbon; (d) manipulating temperature of the transparent lipid carrier solution to be close to a main phase transition temperature thereof; and (e) agitating in a mechanical manner the vessel containing the transparent lipid carrier solution to form micro/nano bubbles within the closed vessel. This method contributes to form micro/nano bubbles with desired diameters in a way of optimal material utilization efficiency. | 2022-07-07 |
20220211883 | FAP-ACTIVATED RADIOTHERANOSTICS AND USES RELATED THERETO - The present disclosure relates to fibroblast-activation protein (FAP)-activated theranostic prodrugs, pharmaceutical compositions comprising them, and methods of treating a disorder characterized by FAP upregulation, such as cancer. | 2022-07-07 |
20220211884 | RK POLYPEPTIDE RADIOPHARMACEUTICAL TARGETING HER2 AND PREPARATION METHOD THEREOF - Disclosed are an rk polypeptide radiopharmaceutical targeting HER2, and a preparation method therefor. The rk polypeptide radiopharmaceutical comprises an rk polypeptide dimer and a radionuclide, wherein the radionuclide marks the rk polypeptide dimer by means of a chelating agent, the rk polypeptide dimer is a polypeptide dimer formed by connecting PKM and rk polypeptide monomers and then dimerizing two rk polypeptide monomers connected to the PKM; each rk polypeptide monomer is a D-type amino acid linear eight-membered polypeptide, and the sequence of the rk polypeptide monomer is as follows: Arg-Asn-Trp-Glu-Leu-Arg-Leu-Lys; and the PKM represents a pharmacokinetic modifying molecule. The radiopharmaceutical is used for imaging diagnosis of HER2-positive tumor patients, and medication guidance and real-time therapeutic effect monitoring of patients treated by monoclonal antibodies of the anti-cancer drug trastuzumab. | 2022-07-07 |
20220211885 | COMPOSITIONS AND METHODS OF IMMUNODEPLETION FOR THE TREATMENT OF MALIGNANT AND NON-MALIGNANT HEMATOLOGICAL DISEASES - This invention provides a method for depleting a subject's hematopoietic stem cells that includes administering to the subject an effective amount of a radiolabeled antibody against CD34, CD117, or CD135, where preferred radiolabels include | 2022-07-07 |
20220211886 | COMBINATION RADIOIMMUNOTHERAPY AND CD47 BLOCKADE IN THE TREATMENT OF CANCER - Provided are compositions and methods for treating cancers and precancerous proliferative disorders in a mammalian subject that involve the combination use of a radiotherapeutic agent, such as a radiolabeled CD33, DR5, 5T4, HER2, HER3, or TROP2 targeting agent, and a CD47 checkpoint inhibitor, such as a SIRPα-IgG Fc fusion protein or a monoclonal antibody against CD47 or SIRPα. | 2022-07-07 |
20220211887 | COMPOSITION OF RADIOACTIVE AND NON-RADIOACTIVE MICROPARTICLES - The present disclosure provides a composition that includes a mixture of (i) radioactive microparticles; and (ii) non-radioactive microparticles. The radioactive microparticles may be suitable to treat a vascularized tumour, such as a liver tumour or a metastasized liver tumour. The radioactive microparticles and the non-radioactive microparticles may have substantially the same resistance when flowing in a liquid through a conduit. The present disclosure also provides methods of making and methods of using mixtures of microparticles. | 2022-07-07 |
20220211888 | METAL WORKING FLUID DECONTAMINATION APPARATUS - Metal working fluid decontamination apparatus ( | 2022-07-07 |
20220211889 | ULTRAVIOLET DEVICE AND METHODS OF USING THE SAME - A device including an outer shell having a first longitudinal axis and a first arcuate shape. The outer shell is opaque to ultraviolet light and to visible light. The device also includes an inner shell having a second longitudinal axis. The inner shell is connected longitudinally to the outer shell along a first longitudinal length and a second longitudinal length. The inner shell has a second arcuate shape different than the first arcuate shape. A chamber is disposed between the outer shell and the inner shell. The chamber is defined by a difference between the first arcuate shape and the second arcuate shape. The device also includes an ultraviolet light source disposed along the second longitudinal axis. | 2022-07-07 |
20220211890 | ULTRAVIOLET LIGHT EMITTER - A light emitting assembly comprises an ultraviolet (UV) light emitting diode (LED) coupled to a UV reflector. The reflector has a three-dimensional shape spanning an angular range between 0° and 180° about a principal reflector axis of the reflector. The reflector is smooth and continuous across its entire surface. The UV-LED is directed towards a reflective surface of the reflector instead of towards the fluid to be treated. A central ray of the UV-LED impinges directly on the reflective surface of the reflector. | 2022-07-07 |
20220211891 | Methods and Devices for Portable Sterilization and Containment of Medical Devices - An at-home sterilization and data acquisition and deposition device including a housing having an opening or series of openings for receiving up to six medical devices, a sterilization chamber formed within the housing that is lined with sterilizing radiation reflecting material, and several sources of sterilizing radiation disposed within the sterilization chamber for sufficient emission of radiation to achieve a significant log reduction of any pathogens present on the medical devices, and an RFID scanner and sensor suite configured into the housing that prevents sterilization of non-system components, radiation emission into the environment, and that can pair with a user's mobile device. An individual catheterization system includes an at-home sterilization and data acquisition device, a software-enabled analysis of data acquired through the system, a set of accessories to enable proper lubrication, cleaning, and radiation-based sterilization of medical devices, and a set of RFID-enabled medical devices designed to facilitate sterile emptying of the bladder by providing a tactile interface that prevents direct contact between the individual and the parts of the medical devices that enter the individual's body. | 2022-07-07 |
20220211892 | HYGIENE SYSTEM FOR A PORTABLE PACKAGED FOOD CONTAINER - A system may automatically conduct hygiene cycles for a confined space such an interior space of a box suitable for storing and/or carrying packaged food. The system may include a hygiene device that can be attached to the box to conduct the hygiene cycles. The system may also automatically collect information related to the hygiene cycles and transmit the collected information to a network. | 2022-07-07 |
20220211893 | AIR CONDITIONER - Provided is an air conditioner including an irradiation unit that irradiates an irradiation area of an indoor unit with ultraviolet rays, a temperature detection unit that detects an ambient temperature of the irradiation unit, and a control unit that controls an irradiation time of the irradiation unit. The control unit controls the irradiation time in accordance with the ambient temperature detected by the temperature detection unit. | 2022-07-07 |
20220211894 | PHOTOCATALYTIC GENERATION OF SINGLET OXYGEN FOR AIR PURIFICATION - Aspects disclosed herein include a system for generating singlet oxygen in a gas, the system comprising: a substrate; and hexanuclear clusters operably immobilized on at least a portion of the substrate; wherein each hexanuclear cluster comprises a photosensitive octahedral core complex characterized by formula FX1a: M | 2022-07-07 |
20220211895 | AIR STERILIZATION DEVICE - An air sterilization device includes a reflector, a first LED light source, and a second LED light source. The reflector may include a body part having a circular column shape having a vacant space therein and having openings formed in upper and lower surfaces thereof, a first rotary body connected to a lower surface of the body part and shaped to have a vacant space therein, and a second rotary body connected to an upper surface of the body part and shaped to have a vacant space; a first LED light source may emit UV-C rays in a direction from the first rotary body to the body part; and a second LED light source may emit UV-C rays in a direction from the second rotary body to the body part, and the reflector may reflect the light emitted from the first LED light source and the light emitted from the second LED light source. | 2022-07-07 |
20220211896 | ANTIMICROBIAL SYSTEMS FOR PERSONAL SPACES - An air purification system, includes a UVC light source arranged within an internal space of a purification chamber and adapted to irradiate the internal space with UVC, an airflow system arranged to introduce environmental air from outside of the air purification system into the internal space of the purification chamber and expel purified air from the purification chamber back outside of the air purification system, and a light blocking system arranged to block a substantial amount of the irradiated UVC from emitting outside of the air purification system, the light blocking system comprising a high-air-flow open structure mounted in the airflow system of the purification chamber, wherein the open structure comprises a front surface, rear surface and a thickness, wherein the front and rear surfaces have a plurality of open areas connected through the thickness, and wherein at least one of the plurality of open areas is of a size with respect to the thickness to block light from traversing the thickness when an angle of incidence is less than approximately 10 degrees. | 2022-07-07 |
20220211897 | FLUID PURIFICATION SYSTEMS AND METHODS - Purification assemblies and methods of use. A method of using a purification assembly, the purification assembly having a housing having a first open end and an opposite second open end, the housing defining an interior volume, and a longitudinal axis extending between the first open end and the second open end. The method includes forming a ring of UV radiation sources on an interior surface of the housing, wherein the longitudinal axis extends through the ring, and wherein at least a first set of the UV radiation sources lie on a plane. The method also includes causing the first set of UV radiation sources to emit UV radiation along the plane and flowing a stream of air through the housing toward the ring of UV radiation sources, wherein the intensity of the UV radiation exceeds a threshold along the entirety of the plane within the housing. | 2022-07-07 |
20220211898 | SILICA FIBER HEMOSTATIC DEVICES AND METHODS - Embodiments of the invention include hemostatic compositions, delivery devices, kits, and methods utilizing silica fibers or other silica fiber compositions. The fiber compositions may be formed via electrospinning of a sol gel produced with a silicon alkoxide reagent, such as tetraethyl ortho silicate, alcohol solvent, and an acid catalyst. | 2022-07-07 |
20220211899 | PEPTIDE EXHIBITING EXCELLENT ADHESION TO RESINS AND BIOCOMPATIBLE FUNCTIONAL MATERIAL USING SAME - The present invention provides a biocompatible material improved in biocompatibility owing to adsorption of a peptide that has high adhesion with a resin and hardly separates from a surface of the resin, and a functional material including the biocompatible material. The biocompatible material includes a resin and a peptide adsorbed on the resin. The resin has methoxycarbonyl groups and methyl groups, and tryptophan or arginine accounts for 70% or more of amino acid residues in the peptide. As an alternative, the resin is a fluorinated resin, and 2,3,4,5,6-pentafluoro-phenylalanine, 3-(trifluoromethyl)alanine, serine, threonine, histidine, aspartic acid, glutamic acid, phenylalanine, or aspartic acid accounts for 40% or more of the amino acid residues in the peptide. The functional material includes the biocompatible material, and a functional substance. The functional substance is held on a surface of the biocompatible material or is released from the surface of the biocompatible material. | 2022-07-07 |
20220211900 | REACTIVE DRY POWDERED HEMOSTATIC MATERIALS COMPRISING A PROTEIN AND A MULTIFUNCTIONALIZED MODIFIED POLYETHYLENE GLYCOL BASED CROSSLINKING AGENT - Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are described. The compositions may comprise a first component comprising a multifunctionalized polymeric composition (e.g., multifunctionalized polyethylene glycol) functionalized with electrophilic reactive groups, and a second component that comprises a protein such as albumin. The compositions may in certain applications act as hemostats when applied in dry powder form to a bleeding wound, whereupon the first component and the second component of the composition crosslink to form a hydrogel. | 2022-07-07 |
20220211901 | THROMBIN-FREE HEMOSTATIC MATERIALS, METHODS OF MANUFACTURE, AND USES THEREOF - Disclosed herein are hemostatic materials and methods of production and use thereof. | 2022-07-07 |
20220211902 | TWO-COMPONENT SYSTEM FOR THE THERAPEUTIC TREATMENT OF SKIN LESIONS AND PRODUCTION METHOD THEREOF - A two-component system for the therapeutic treatment of skin lesions includes two components. A first component is an aqueous gel. A second component, called cross-linker, is an aqueous solution. The first component includes at least one biocompatible polymer, at least one polyacid or a salt thereof and characterized in that at least one preservative substance, at least one pharmacologically active substance can be present and in that the second component consists of a saline solution including calcium chloride, magnesium chloride and zinc chloride. A method of use involves the prior application of the first component, in the form of aqueous gel in a fluid-viscous state on the skin of a patient, then spraying with the second component as an aqueous solution, causing the formation in situ of a film of rubbery consistency and in that the rubbery film can be removed by washing the skin with water. | 2022-07-07 |
20220211903 | POSS VISCOELASTIC HEMOSTATIC AGENTS - A fluidic hemostat agent comprising a solid hemostatic additive suspended in a silanol carrier fluid to form a heterogeneous mixture that exhibits sufficient flowability to allow for injection and proliferation, while simultaneously having sufficient adhesive and viscoelastic characteristics to remain at the application site and enable the clotting cascade time to form a thrombus. The silanol carrier fluid preferably comprises liquid silanol-bearing POSS molecules, while the solid hemostatic additive preferably is selected from the group consisting of kaolin, chitin, chitosan, cellulose, keratin pectin, acetylated glucosamine, dry fibrin, gelatin, and calcium salts. A preferred silanol species is iso-octylPOSS trisilanol having the molecular representation [(i-ocylSiO | 2022-07-07 |
20220211904 | POLY(GLYCEROL SEBACATE) URETHANE ELASTOMERIC LEAFLET FOR HEART VALVE REPLACEMENT - A leaflet for a heart valve replacement includes poly(glycerol sebacate) urethane. A heart valve replacement includes a leaflet including poly(glycerol sebacate) urethane. A process forms a leaflet for a heart valve replacement. The process includes casting a first solution including poly(glycerol sebacate) and isocyanate to form a leaflet composition including poly(glycerol sebacate) urethane. The process also includes shaping the leaflet composition to form the leaflet. | 2022-07-07 |
20220211905 | MICROSTRUCTURED HAPTOTAXIC IMPLANT - The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body. | 2022-07-07 |
20220211906 | METHOD FOR COATING A MEDICAL DEVICE AND COATED MEDICAL DEVICE - The present invention relates in a first aspect to a method for coating a medical device suitable for implantation into an individual or for application on skin or mucosal tissue of an individual. Said method comprises the steps of applying to at least a portion of the surface of said device a coating layer whereby said coating layer comprises commensal microorganisms, like commensal bacteria, to form a biofilm on the at least portion of the surface of said medical device, further comprising the step of drying the biofilm coated on the surface of said medical device whereby the commensal microorganisms are eventually killed in case they were not applied as killed microorganisms in the step above, for obtaining a medical device having at least a portion of its surface coated with non-living commensal microorganisms In a further aspect, the coated medical devices obtainable by the method according to the present invention are provided. The coated medical devices according to the present invention are particularly useful in applications being mucosal tissue or a skin of an individual, like for use as an implant for dental use in the oral cavity. Finally, the present invention relates to the use of commensal bacteria like | 2022-07-07 |
20220211907 | EXTRACELLULAR MATRIX (ECM) STRUCTURES FOR TISSUE REGENERATION - The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue. | 2022-07-07 |
20220211908 | DECELLULARIZED EXTRACELLULAR MATRIX, PREPARATION PROCESS AND USES THEREOF - The present disclosure provides a decellularized extracellular matrix, the preparation process and uses thereof. The decellularized extracellular matrix of the present disclosure is derived from a three-dimensional cell spheroid, and the decellularized extracellular matrix has a three-dimensional spherical structure. The decellularized extracellular matrix of the present disclosure can be used to prepare a biomedical material scaffold for promoting tissue regeneration and repair. | 2022-07-07 |
20220211909 | MENISCUS TEAR REPAIR SLING DEVICE - A meniscus tear repair sling device has a collagen membrane having a first end portion and a second end portion. The first end portion is configured to pass under a tear in a meniscus and wrap over and above the tear and extend past the meniscus and overlay the second end portion thereby enveloping a portion of the meniscus with a tear and forming the sling device. The first end portion and the second end portion form exposed overlying tails extending external of a knee joint. The tails are configured to be affixed to a portion of a tibia. The tails when tensioned close the tear by providing a lateral strain on the torn meniscus when the tails are affixed to a tibia adjacent the knee joint. | 2022-07-07 |
20220211910 | BIOLOGICAL TRANSPLANTATION MATERIAL - An object of the present invention is to provide a bone regenerative agent showing a high bone regeneration effect. According to the present invention, a bone regenerative agent containing gelatin-containing granules and stem cells is provided. Gelatin preferably has repetitions of a sequence represented by Gly-X-Y, which is characteristic of collagen. Here, a plurality of Gly-X-Y's may be the same as or different from each other, and in the formula, X and Y each independently represent any of amino acid. A molecular weight of the gelatin is preferably 2 KDa or more and 100 KDa or less. | 2022-07-07 |
20220211911 | PATCH GRAFT COMPOSITIONS FOR CELL ENGRAFTMENT - Compositions and methods of transplanting cells by grafting strategies into solid organs (especially internal organs) are provided. These methods and compositions can be used to repair diseased organs or to establish models of disease states in experimental hosts. The method involves attachment onto the surface of a tissue or organ, a patch graft, a “bandaid-like” covering, containing epithelial cells with supporting early lineage stage mesenchymal cells. The cells are incorporated into soft gel-forming biomaterials prepared under serum-free, defined conditions comprised of nutrients, lipids, vitamins, and regulatory signals that collectively support stemness of the donor cells. The graft is covered with a biodegradable, biocompatible, bioresorbable backing used to affix the graft to the target site. The cells in the graft migrate into and throughout the tissue such that within a couple of weeks they are uniformly dispersed within the recipient (host) tissue. The mechanisms by which engraftment and integration of donor cells into the organ or tissue involve multiple membrane-associated and secreted forms of MMPs. | 2022-07-07 |
20220211912 | HYDROGEL RETINAL TAMPONADE AGENT - A hydrogel retinal tamponade agent is disclosed herein. The disclosed hydrogel tamponade agent acts as a temporary barrier to fluid flow into the subretinal space and obviates the need to use intraocular gases or silicone oil as a retinal tamponade agent in a retinal detachment repair procedure. The hydrogel tamponade agent remains in place after a permanent seal is achieved and is slowly resorbed. The hydrogel tamponade agent is preferably biocompatible. | 2022-07-07 |
20220211913 | SHAPE MEMORY POLYMER HYDROGELS FOR WOUND HEALING - A shape memory polymer hydrogel that is biodegradable, includes antimicrobial agents, and has a tunable drug delivery is used for wound healing internally and externally. The shape memory polymer is synthesized using a combination of hydrophilic precursors that are configured to have two to four functional end groups, with at least one component that has at least three functional groups. The synthesis route provides for a covalently crosslinked thermoset hydrogel. The chemistry can be tuned to provide desired transition temperatures for delivery (e.g. below 37° C.) and desired pore sizes for healing (e.g. 250-500 μm). | 2022-07-07 |
20220211914 | HYALURONIC ACID HYDROGELS WITH PROLONGED ANTIMICROBIAL ACTIVITY - The present invention concerns a hydrogel comprising hyaluronic acid (HA) or a derivative thereof, loaded with at least one positively charged antimicrobial peptide, wherein said HA or derivative thereof is cross-linked with a cross-linking agent at the level of its hydroxyl moieties while the carboxyl moieties of HA or derivative thereof remain free and said HA or derivative thereof remains negatively charged; and a method for preparing said loaded hydrogel. | 2022-07-07 |
20220211915 | SURGICAL SYSTEM AND METHODS OF USE - A surgical system including an implantable medical device having a size and shape. The surgical device having a substrate and a coating that covers at least a portion of the substrate. The coating includes a polymer, collagen, glycerin and a hemostatic agent. The polymer is selected from the group of polyhydroxybutyrate, polyglycerol sebacate and adducts of polyglycerol sebacate. The substrate including a first piece and a second piece that is joined with the first piece. The first piece and the second piece forming a pocket having a cavity and an opening that is in communication with the cavity. The device being pre-formed such that a size and shape of the cavity conforms to the size and shape of the implantable medical device. | 2022-07-07 |
20220211916 | MEDICAL DEVICE AND METHOD FOR PRODUCING MEDICAL DEVICE - A medical device includes a mottled structure containing silicone and an antibacterial agent at a surface of the medical device. | 2022-07-07 |
20220211917 | LUBRICIOUS COATING FOR MEDICAL DEVICE - Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including an acrylic acid polymer, an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups. The coating can be used on a catheter surface to facilitate its movement in the body. | 2022-07-07 |
20220211918 | USE OF NANOCRYSTALS FOR DRUG DELIVERY FROM A BALLOON - A drug delivery balloon ( | 2022-07-07 |
20220211919 | DURABLE ANTIMICROBIAL LAYER FOR IMPLANTABLE MEDICAL DEVICES - An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate. | 2022-07-07 |
20220211920 | METHOD FOR MOLDING SELF-SUPPORTING SILK FIBROIN CATHETER STENT - The present invention relates to a method for molding a self-supporting silk fibroin catheter stent, which comprises preparing an excellent catheter stent by a mold casting and freeze-drying molding process using silk fibroin as a raw material. The raw material is silk fibroin extracted from natural mulberry silk; and the mold is a hollow tubular mold, having an outer shell that is a transparent polyethylene straw with a diameter of 6 mm and an inner core that is a fiber rod FRP with a diameter of 3 mm, with the two ends being closed. The mold casting and freeze-drying molding process comprises the steps of casting; pre-freezing; removing the mold and placing the mold onto a pre-frozen freeze-drying plate; and freeze-drying. The freeze-drying procedure comprises: (1) a pre-freezing stage; (2) a freezing—vacuum transition stage; (3) a gradient temperature-rising and freeze-drying stage; and (4) a secondary freeze-drying stage. The freeze-drying procedure is strictly regulated in accordance with the specifications of freeze-dried stents. The prepared stent has a good shape, and good tolerance without adding any additional components. The stent presents a three-dimensional porous space structure, the process is simple, and the stent meets the requirements for tissue-engineered vascular stent in clinic. | 2022-07-07 |
20220211921 | SURGICAL SYSTEM AND METHODS OF USE - A surgical system including an implantable medical device having a size and shape. The surgical device having a substrate and a coating that covers at least a portion of the substrate. The coating including collagen, glycerin and a hemostatic agent. The substrate including a first piece and a second piece that is joined with the first piece. The first piece and the second piece forming a pocket having a cavity and an opening that is in communication with the cavity. The device being pre-formed such that a size and shape of the cavity conforms to the size and shape of the implantable medical device. | 2022-07-07 |
20220211922 | SURGICAL SYSTEM AND METHODS OF USE - A surgical device configured to surround an implantable medical device that includes a collagen membrane and a coating embedded in the membrane The coating including at least one active pharmaceutical ingredient. | 2022-07-07 |
20220211923 | Cryoprotective Compositions, Surgical Kits, and Methods for Protection of a Surgical Site During Cryosurgery - A surgical kit for providing a cryoprotective composition configured to be applied during cryotreatment of a patient includes: a first container containing a predetermined amount or volume of a biodegradable and/or bioerodible fluid agent; and a second container containing a predetermined amount or volume of a non-toxic cryoprotectant agent. The predetermined amount or volume of the of biodegradable and/or bioerodible fluid agent and the predetermined amount or volume of a non-toxic cryoprotectant agent are configured to be mixed together to form the cryoprotective composition in which a therapeutically effective amount of the cryoprotective composition deposited in a body space of the patient in proximity to the cryotreatment remains within at least a portion of the body space for a duration of the cryotreatment and at least a portion of a body tissue proximate to the body space is viable after the cryotreatment. | 2022-07-07 |
20220211924 | BLOOD PURIFICATION DEVICE - A blood purification device for blood purification therapy performed through a blood purifier, the blood purification device includes piping; a plurality of sensors of different detection types that are provided on the piping; and a liquid chemical identification unit that identifies a type of a cleaning/disinfection liquid chemical flowing through the piping by using the plurality of sensors. The liquid chemical identification unit is configured to be able to identify types of the liquid chemicals of at least not less than the number of the plurality of sensors by using the plurality of sensors. | 2022-07-07 |
20220211925 | OXYGENATOR WITH WOUND FILTER MEMBRANE AND FLOW DIFFUSER - A blood oxygenator has a housing with a first end opposite a second end and a sidewall extending between the first end and the second end along a longitudinal axis. The housing may define an interior chamber having a fluid inlet and a fluid outlet. The blood oxygenator further has a gas exchange medium positioned within the interior chamber. The gas exchange medium may have a plurality of hollow fibers rolled into a spiral shape. The blood oxygenator further has a flow diverter positioned within the interior chamber and configured for guiding fluid flow through the gas exchange medium. | 2022-07-07 |
20220211926 | SYSTEM AND METHOD FOR PREPARING PERITONEAL DIALYSIS FLUID AT THE TIME OF USE - A peritoneal dialysis system includes first and second concentrate sources in selective fluid communication with a medical fluid pumping cassette, the first and second concentrate sources holding first and second peritoneal dialysis concentrates, respectively; a pump actuator configured to cause the medical fluid pumping cassette to pump the first and second concentrates; and a processor and memory configured to (i) determine a cumulative volume of at least one of the first or second peritoneal dialysis concentrates pumped from the medical fluid pumping cassette by the pump actuator, (ii) compare the cumulative volume to a threshold, and (iii) if the cumulative volume is outside of the threshold, modify a subsequent stroke volume of at least one of the first or second pump chambers actuated by the pump actuator in an attempt to cause an updated cumulative volume for the at least one peritoneal dialysis concentrate to be within the threshold. | 2022-07-07 |
20220211927 | METHOD FOR TRENDNG AUTOMATED PERITONEAL DIALYSIS TREATMENTS - A method for performing a peritoneal dialysis therapy includes performing a plurality of peritoneal dialysis cycles for a patient and tracking an amount of dialysis fluid provided by at least one dialysis fluid pump during the plurality of peritoneal dialysis cycles. The method also includes determining an amount of ultrafiltrate (“UF”) removed from the patient based on the amount of dialysis fluid provided by the at least one dialysis fluid pump. The method further includes updating a UF trend using previous amounts of UF removed from the patient and the amount of UF removed from the patient during the most recent dialysis treatment and generating an alert if the UF trend changes by more than a preset percentage. | 2022-07-07 |
20220211928 | EMPTYING A BLOOD CIRCUIT AFTER EXTRACORPOREAL BLOOD TREATMENT - A blood treatment apparatus ( | 2022-07-07 |
20220211929 | PRESSURE MEASUREMENT IN THE EXTRACORPOREAL BLOOD CIRCUIT - A device and method for calibrating a first pressure sensor. The method includes: a) recursive analysis and forecasting of at least one correction function for finding a correction signal for the correction of a drift signal with the aid of a corresponding pressure reference signal, which is measured by the first pressure reference sensor, at constant internal pressure and at constant internal tube temperature; b) first calibration of a force signal, measured by the first pressure sensor and corrected using the correction signal, with the pressure reference signal, which is measured by the first pressure reference sensor, prior to an active use of the tube; and c) second calibration of the force signal, measured by the first pressure sensor and corrected using the correction signal, with the pressure reference signal, which is measured by a second pressure reference sensor during an active use of the tube. | 2022-07-07 |
20220211930 | COAXIAL CANNULA FOR USE WITH EXTRACORPOREAL MEMBRANE OXYGENATION SYSTEMS - The present disclosure is directed to a coaxial cannula assembly including an infusion tube defining a return lumen and having a proximal end and a distal end. The distal end of the infusion tube includes a plurality of infusion openings and a flow restriction member positioned between the plurality of infusion openings and a distal tip of the infusion tube. The cannula assembly also includes a drainage tube co-axially aligned with the infusion tube and having a proximal end and a distal end. The distal end of said drainage tube includes a plurality of drainage openings and a length of the drainage tube is less than a length of the infusion tube. The cannula assembly further includes a drainage lumen defined by a space between said infusion tube and said drainage tube. | 2022-07-07 |
20220211931 | OPHTHALMIC PRESSURE CONTROL SYSTEM, A KIT OF PARTS AND A METHOD - The invention relates to an ophthalmic pressure control system, comprising: a pressure regulator having an input port and an output port, and an infusion line having a proximal end and a distal end, the proximal end being connected to the output port of the pressure regulator, and the distal end being detachably connected to an ophthalmic irrigation module. Further, the system includes a control unit driving the pressure regulator for controlling an infusion fluid pressure at a distal end of the ophthalmic irrigation module. The control unit is arranged for performing a fluid calibration process including a step of determining a fluid impedance of the ophthalmic irrigation module. The infusion line is associated with a kit of parts including a first and a second ophthalmic irrigation device, or the ophthalmic irrigation module is an ophthalmic irrigation device for surgical use. | 2022-07-07 |
20220211932 | Tissue Interface With Integral Fluid-Control Layer - Tissue dressing materials and associated methods of forming such dressing materials are disclosed. In one example embodiment, a dressing material may include a foam and a film formed on a first side of the foam. The film may be integrally-formed on the side of the foam. The film may include a plurality of apertures. A method of making the dressing material may include placing a pre-polymer mixture and water into a mold to create the dressing material comprising a foam and an integral film on at least one surface of the foam. The method may further include forming a plurality of openings in at least the integral film, with the openings being formed within the mold or subsequent to removal of the dressing material from the mold. | 2022-07-07 |
20220211933 | SYSTEMS AND METHODS FOR EXTENDING OPERATIONAL TIME OF NEGATIVE PRESSURE WOUND TREATMENT APPARATUSES - A negative pressure wound therapy system can include a source of negative pressure negative pressure configured to aspirate fluid from a wound covered by a wound dressing and electronic circuitry with a power source, boost converter circuitry configured to receive power at a first level from the power source and supply power at a second level to the source of negative pressure, the second level being higher than the first level, and a controller configured to, in response to a determination that a capacity of the power source is being depleted, cause the boost converter circuitry to supply power to the source of negative pressure at a third level lower than the second level. The controller can further lower a target negative pressure level associated with negative pressure provided by the source of negative pressure. | 2022-07-07 |
20220211934 | CASSETTE ASSEMBLY FOR AMBULATORY DRUG PUMP - A cassette for attachment and use with an infusion pump apparatus. The cassette head having a low profile cassette head for attaching to the infusion pump apparatus and a flexible reservoir attached to the cassette head that can be filled with a fluid to be administered to a patient. The reservoir is enclosed in a flexible cover attached to the cassette. The flexibility of the cover and the reservoir inhibits the cassette head from disengaging from the infusion pump apparatus and allows the infusion pump apparatus to be primed by squeezing or pressing the cover and reservoir. | 2022-07-07 |
20220211935 | Needle Hub and Applicator for Drug Delivery Device - A needle hub for a drug delivery device includes an applicator having a needle holder, a needle attached to the needle holder, a needle retraction spring, and an activation button, and a hub body including a cannula holder, a cannula attached to the cannula holder, a cannula withdrawal button, and a cannula retraction spring. At least a portion of the hub body is configured to be received within the applicator, with the applicator configured to be separated from the hub body. Movement of the activation button is configured to move the needle holder and the cannula holder from a retracted position to an insertion position. The cannula withdrawal button locks the cannula holder in the insertion position against a biasing force of the cannula retraction spring when the cannula holder is moved from the retracted position to the insertion position. | 2022-07-07 |
20220211936 | Needle Hub with Pressure Interlock for Drug Delivery Device - A needle hub for a drug delivery device includes a needle holder and a needle attached to the needle holder, a needle actuation assembly configured to move the needle holder from a retracted position, to an insertion position, and back to the retracted position, and a pressure interlock comprising an inlet configured to be in fluid communication with a fluid source, an outlet in fluid communication with the needle, and a lock member. The lock member having a first position where the lock member prevents actuation of the needle actuation assembly and a second position where the lock member allows actuation of the needle actuation assembly. The lock member is moved from the first position to the second position based on a pressure within the pressure interlock. | 2022-07-07 |
20220211937 | WEARABLE PUMP ASSEMBLY - A wearable infusion pump assembly includes a reusable housing assembly, and a disposable housing assembly including a reservoir for receiving an infusible fluid. A releasable engagement assembly is configured to allow the reusable housing assembly to releasably engage the disposable housing assembly. A detachable external infusion set is configured to deliver the infusible fluid to a user. | 2022-07-07 |
20220211938 | FLUID DELIVERY DEVICE, TRANSCUTANEOUS ACCESS TOOL AND FLUID DRIVE MECHANISM FOR USE THEREWITH - A fluid delivery device comprising a fluid reservoir; a transcutaneous access tool fluidly coupled to the fluid reservoir; and a drive mechanism for driving fluid from the reservoir, the drive mechanism comprising a plunger received in the reservoir; a leadscrew extending from the plunger; a nut threadably engaged with the leadscrew; a drive wheel; and a clutch mechanism coupled to the drive wheel, wherein the clutch mechanism is configured to allow the nut to pass through when disengaged and is configured to grip the nut when engaged such that the drive wheel rotates the nut to advance the drive rod and the plunger into the reservoir. | 2022-07-07 |
20220211939 | Needle Hub for Drug Delivery Device - A needle hub for a drug delivery device includes a hub body, an activation button, a needle holder and a needle attached to the needle holder, a cannula holder and a cannula attached to the catheter holder, a needle actuation mechanism configured to move the needle holder and the cannula holder from a retracted position to an insertion position and configured to move the needle holder back to the retracted position, and a cannula spring biasing the catheter holder to a retracted position. Movement of the activation button is configured to cause the needle holder and the catheter holder to move from the retracted position to the insertion position, with the needle holder configured to return to the retracted position while the catheter holder remains in the insertion position. | 2022-07-07 |
20220211940 | Drug Delivery Device with Needle Hub - A drug delivery device includes a housing, a fluid reservoir received within the housing, a drive assembly configured to dispense fluid from the fluid reservoir, a needle hub actuator attached to the housing, and a needle hub at least partially received by the housing. The needle hub includes a hub body, a needle holder with a needle attached to the needle holder, and a cannula holder with a cannula attached to the cannula holder. The needle hub actuator is configured to move the needle holder and the cannula holder from a retracted position where the needle and the cannula are positioned within the hub body to an insertion position where the needle and the cannula are positioned within the hub body. The needle hub is detachable from the housing. | 2022-07-07 |
20220211941 | INTEGRATED DRUG INFUSION DEVICE - The invention discloses an integrated drug infusion device, comprising: infusion unit configured to deliver drugs; program unit comprising input end and output end, and the input end comprises a plurality of electrically connective regions for receiving signals of analyte data in the body fluid, after the output end is electrically connected to the infusion unit, according to the received signals of analyte data in the body fluid, the program unit controls whether the infusion unit delivers drugs; an infusion cannula with conductive area, the infusion cannula is the drug infusion channel; and a plurality of electrodes for detecting analyte data in body fluid, the electrode comprising conductive-area electrode and cannula-wall electrode, the conductive area of the infusion cannula being at least as a conductive-area electrode, and one or more cannula-wall electrodes being located on/in the wall of the infusion cannula. It takes only one insertion to perform both analyte detection and drug infusion. | 2022-07-07 |
20220211942 | Adjustable Medium Diverter - A system for delivering an amount of fluid medium includes an injector, a delivery catheter and a pulsatile generator. The injector is configured for injecting the fluid medium during an injection cycle. The delivery catheter includes a conduit for delivering the fluid medium. The pulsatile generator is configured to apply a pulsatile force on the fluid medium delivered through the delivery catheter at a pulsation frequency. The pulsatile force is defined by a plurality of duty cycles during the injection cycle, each of the plurality of duty cycles including a first flow level and a second flow level that is lower than the first flow level. The pulsation frequency is 3 or more duty cycles per second. | 2022-07-07 |
20220211943 | Methods and systems for closed-loop control of drug administration - A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug. | 2022-07-07 |
20220211944 | CONTINUOUS GLUCOSE MONITORING TREND-ENABLED DOSE CALCULATOR - Disclosed are systems and methods for determining a dose of insulin that compensates for past carbohydrates consumed, adjusts for blood glucose (BG) trend as well as BG value, and mitigates potential inaccuracies associated with double-counting or overcorrecting, where safeguards are applied to the determination of the insulin dose. | 2022-07-07 |
20220211945 | MEDICATION INJECTION SYSTEM - An automatic injection device is provided, where the device includes a syringe carrier and a retraction assembly. The syringe carrier may include two identical parts that are discrete from one another and interlock with one another. Carrier includes a cushion to support the syringe. Protrusions may be provided on cushion to further support syringe. The retraction assembly includes a shuttle and a follower, the follower having a moveable latch. The follower has a coupled configuration in which the latch is biasedly coupled to the shuttle, and a decoupled configuration in which the latch is in sliding engagement with a curvilinear surface of the shuttle. | 2022-07-07 |
20220211946 | AUTO-INJECTOR - An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection. | 2022-07-07 |
20220211947 | Auto-Injector - According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slibably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P). | 2022-07-07 |
20220211948 | SUPPLEMENTARY DEVICE FOR A MEDICAMENT DELIVERY DEVICE - A supplementary device configured to be mounted externally to a medicament delivery device provided with a dose setting knob, wherein the supplementary device has a sleeve configured to be arranged around a portion of the medicament delivery device, wherein the sleeve has a main body having a proximal sleeve end and a distal sleeve end, wherein the main body is provided with a flexible dose setting knob positioning structure which extend distally from the distal sleeve end. | 2022-07-07 |
20220211949 | AN ADAPTOR FOR A MEDICAMENT DELIVERY DEVICE AND A RELATED METHOD - The invention provides an adaptor for a medicament delivery device is configured to enable a set dosage of a medicament to be drawn into and/or expelled from the device, the adaptor including: a body configured to be coupled to the device; an attachment portion movable with respect to the body and configured for attachment with a first part of the device; an engaging portion movable with the attachment portion; and a receiver configured to receive a movement constraint guide (MCG) and facilitate engagement between the engaging portion and the MCG; wherein the MCG includes one or more physical features defining at least an aspect of the set dosage; and wherein activation of said first part of the device to draw and/or expel the medicament is stopped when the set dosage is reached by engagement between the engaging portion and at least one of the one or more physical features of the MCG. The invention thus allows ready control of one or more aspects of dosage administration, which can be the amount of a dose and/or or the repeats of a dose. | 2022-07-07 |
20220211950 | DETACHABLE NEEDLE PROTECTION CAP FOR INJECTION DEVICES - The invention relates to a detachable needle protection cap for injection devices and to a method for producing same. The detachable needle protection cap comprises a housing and at least two shell parts which can be attached to an outer surface of the housing, the shell parts being fastened to an outer surface of the housing. The shell parts can mutually prevent removal of the shell parts. | 2022-07-07 |
20220211951 | AUTOINJECTOR - An autoinjector includes a case having a rib, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case and adapted to hold a medicament container, and a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier. The needle shroud is movable between a first extended position, a retracted position and a locked second extended position. The carrier is movable from a first axial position to a second axial position relative to the case. The collar abuts the rib when the needle shroud is in the first extended position and the carrier is in the first axial position, and the collar disengages the rib when the needle shroud is in the retracted position and the carrier is in the second axial position. | 2022-07-07 |
20220211952 | Needle Hub for Drug Delivery Device - A needle hub for a drug delivery device includes a hub body, an activation button, a needle holder moveable relative to the hub body, a needle attached to the needle holder, a needle spring biasing the needle holder to a retracted position where the needle is positioned within the hub body, a cannula holder moveable relative to the hub body and the needle holder, a cannula attached to the cannula holder, with the cannula configured to be in fluid communication with a fluid source, and a cannula spring biasing the cannula holder to a retracted position. Movement of a portion of the hub body is configured to disengage a connection between the cannula holder and the hub body to allow the cannula holder to return to the retracted position. | 2022-07-07 |
20220211953 | FINE NEEDLE INJECTION THERAPY DEVICE - This document describes methods and materials for improving cancer treatment. For example, this document describes methods and devices for local tumor control and customizable patient treatment. | 2022-07-07 |
20220211954 | SYSTEM AND METHOD FOR SYRINGE FLUID FILL VERIFICATION AND IMAGE RECOGNITION OF POWER INJECTOR SYSTEM FEATURES - A fluid injection system and a fluid verification system for determining the operating status of the fluid injection system, for example by confirming that a fluid reservoir, containing a fluid for injection, is fully filled with fluid and has free space (i.e., air) near the distal end thereof when the syringe is provided in an upright position nor contains air bubbles. Imaging processing techniques, methods, and systems are also provided to determine various injection parameters and to verify the type and certain properties of fluid that is present within the fluid reservoir. | 2022-07-07 |
20220211955 | PUNCTURE-ASSISTANCE TOOL, PUNCTURE DEVICE, AND PUNCTURE METHOD - The present invention has an object to cause no pain to a living body and prevent a needle from being buckled. A puncture assisting tool ( | 2022-07-07 |
20220211956 | ATOMIZATION DEVICE - An atomization device includes a liquid storing member that stores a liquid therein, a carrier detachably assembled to the liquid storing member, an opener disposed on at least one of the liquid storing member and the carrier, and an atomizing module that is assembled to at least one of the liquid storing member and the carrier. The opener is configured to form an opening on the liquid storing member. The atomization device has a buffering chamber arranged between the atomizing module and the opening of the liquid storing member, and a volume of the buffering chamber is less than a volume of the liquid. The liquid storing member can be pressed to change an inner pressure thereof, such that a part of the liquid is driven to flow from the opening into the buffering chamber for an atomizing process of the atomizing module. The buffering chamber can receive the liquid stored in the liquid storing member over multiple times, such that the atomization device can atomize the liquid over multiple times through the buffering chamber. | 2022-07-07 |
20220211957 | COLLAPSIBLE, DISPOSABLE MEDICATION INHALATION SPACER AND METHOD - A medication inhalation apparatus preferably formed of a single, unitary sheet of stock, includes an outer housing, movable between collapsed and expanded states, encompassing a first volume. An inner housing within the outer housing encompasses an inner or second volume. An inhaler opening to the first volume is within a wall of the outer housing at a first location. A mouth opening to the inner volume is within a wall of the outer housing and the inner housing at a second location. A one-way inhalation valve connecting the first volume and the inner volume is within a wall of the inner housing. A one-way exhalation valve connecting the inner volume and the exterior of the outer housing is within a wall of the outer housing and inner housing at a third location. The valve preferably includes an elongated spring body formed of a semi-pliant material with a strength and rigidity providing limited flexibility. A first separation is perpendicular to the elongate axis of the spring body, and extends from a first edge of the spring body across at least a portion of a width of the spring body. A second separation perpendicular to the elongate axis of the spring body extends from a second edge of the spring body across at least a portion of the width of the spring body. | 2022-07-07 |
20220211958 | METHODS, DEVICES AND SYSTEMS FOR PULMONARY DELIVERY OF ACTIVE AGENTS - Provided herein is a method of pulmonary delivering to a subject at least one pharmacologically active agent being in a plant material, which is effected by pulmonary delivering the agent to the subject using a metered dose inhaler device that is configured to vaporize at least one pre-determined vaporized amount of the agent upon controllably heating the plant material, wherein the pre-determined vaporized amount is selected so as to achieve at least one pre-determined pharmacokinetic effect and/or at least one pre-determined pharmacodynamic effect induced by the agent in the subject. | 2022-07-07 |
20220211959 | EMERGENCY INCISION AND DILATION APPARATUS AND METHOD - An incision and dilation apparatus performs an incision in and dilates select tissue of a mammal. The apparatus includes a blade member, a dilator, and a frame. The blade member includes a blade having a cutting edge. The dilator is configured to dilate the select tissue. The frame includes a blade guide, and is adapted to position the blade guide over the select tissue. The blade guide retains the blade member in first and second perpendicular directions and allows substantially linear movement of the blade member in a third direction. The frame also supports the dilator and allows movement of the dilator in the third direction. The dilator includes a second blade guide that retains the blade member in first and second perpendicular directions and allow substantially linear movement of the blade member relative to the dilator in a third direction. | 2022-07-07 |
20220211960 | A SYSTEM FOR DELIVERING INHALED THERAPIES - An inhaler comprises (a) a first passage having a first open end and a second open end; (b) a pressure source configured for generating an airflow; said pressure source connected to said first open end of said first passage; (c) a rotating shutter configured for blocking and releasing said airflow; (d) a mouthpiece being in fluid communication with second open end of said first passage; said mouthpiece configured for delivering a modulated airflow to a patient's airway. The inhaler further comprises a second passage having first open end and a second open end; said first open end of said second passage is in fluid communication with said mouthpiece; said second open end of said second passage is vented to ambient air; said first and second passages are arranged such that said rotating shutter blocks and releases said first and second passages in an alternate manner. | 2022-07-07 |
20220211961 | TRACHEOSTOMY TUBE ASSEMBLIES AND PROTECTORS - A paediatric tracheostomy tube (1) has a protector (50) covering the cuff inflation indicator (37) to prevent damage to the inflation indicator caused by the patient chewing or biting it. The protector is in two parts: a base (52) extending around the open machine end (40) of the indicator and through which the inflation valve can be accessed, and a transparent sleeve (60) extending around the inflation balloon (38) and through which the balloon is visible. The sleeve has a small opening (65) at its patient end opening to a longitudinal slot (66) along one side so that the sleeve can be assembled on the inflation line (31) by threading the inflation line sideway through the slot. | 2022-07-07 |
20220211962 | NASAL MASK AND SECUREMENT SYSTEM - A patient interface for respiratory therapy includes a mask seal body defining a breathing chamber and having a user-contacting surface configured to contact a face of the user and surround at least the nares of the user. The patient interface also includes a pair of facial pads, each of the facial pads configured to engage the face of a user on opposing sides of the mask seal body. The facial pads are coupled to the mask seal body. The patient interface comprises a sealing mechanism configured to urge the mask seal body toward the user's face to create or maintain sealing engagement between the user-contacting surface and the user's face. In some configurations, the sealing mechanism includes a curved bridging portion that extends between the mask seal body and each of the facial pads. | 2022-07-07 |
20220211963 | BREATHING ASSISTANCE APPARATUS - A mask assembly for use as part of an apparatus for supplying a flow of respiratory gases to a user is disclosed. The mask assembly includes a mask body having an inlet through which said flow of respiratory gases are provided to the interior of said mask body. A mask seal assembly comprising a seal of flexible material and a clip of rigid material is attached to the body. The seal has a first side and a second side. The first side of the seal is shaped to approximately match the contours of a user's face and in use substantially seal against a user's face. The second side is attached to the clip. The clip provides an interface extending substantially the full perimeter or periphery of the mask seal assembly for releasably attaching the mask seal assembly to the mask body. The clip comprises a bridging portion spanning outwards from the perimeter or periphery of the mask body to space at least a portion of the second side of the seal outwards from the perimeter or periphery of the mask body. | 2022-07-07 |
20220211964 | CONDUIT FOR RESPIRATORY THERAPY APPARATUS - A respiratory conduit apparatus that conducts a breathable gas for respiratory therapy may include electrical circuit components to assist with therapy. In an example, a delivery conduit for connection with a patient interface and a respiratory therapy device may include a cuff having a microcontroller unit. The cuff may be configured with circuit components for accessory identification, gas characteristic detection for therapy control, heating and communications. In some versions, the delivery conduit may include a controller in a circuit board assembly located at an end of the delivery conduit. The printed circuit board may be configured to control and power the components of the cuff, as well as communicate with a respiratory therapy device. | 2022-07-07 |