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27th week of 2013 patent applcation highlights part 53
Patent application numberTitlePublished
20130172490COPOLYMER AND METHOD FOR MANUFACTURING THE SAME - In one embodiment of the disclosure, a copolymer and method for manufacturing the same are provided. The copolymer is copolymerized from a composition including: (a) a first hydrophilic monomer, including itaconamic acid, itaconamic salt, or combinations thereof; and (b) a second hydrophilic monomer, including acrylic acid, acrylic salt, acrylamide, or combinations thereof.2013-07-04
20130172491Method for Functionalization of Nanoscale Fibers and Nanoscale Fiber Films - A method is provided for functionalizing nanoscale fibers including reacting a plurality of nanoscale fibers with at least one epoxide monomer to chemically bond the at least one epoxide monomer to surfaces of the nanoscale fibers to form functionalized nanoscale fibers. Functionalized nanoscale fibers and nanoscale fiber films are also provided.2013-07-04
20130172492MODIFIED HIGH CIS CONJUGATED DIENE COPOLYMER AND PREPARING METHOD OF THE SAME - A modified conjugated diene copolymer and a preparing method for the same are provided. The method comprising a polymerization step for polymerizing conjugated diene monomers to form a conjugated diene polymer; and a modifying step for reacting the conjugated diene polymer with a modifier to form a modified conjugated diene polymer. The modifier includes a polythiol ester compound, a polythiol alkane compound or a combination thereof, the polythiol ester compound has a chemical formula (I):2013-07-04
20130172493PROCESS FOR MAKING DENDRITIC POLYOLEFINS FROM TELECHELIC POLYCYCLIC OLEFINS - A process for making dendritic hydrocarbon polymers by reacting an amount of one or more telechelic hydrocarbon polymers with an amount of one or more multifunctional coupling agents under conditions sufficient to produce the dendritic hydrocarbon polymer. The telechelic hydrocarbon polymer is made by ring opening metathesis polymerization (ROMP) in the presence of bi-functional alkene chain terminating agents (CTAs). The dendritic hydrocarbon polymer can be hydrogenated to produce a substantially saturated dendritic hydrocarbon polymer. The dendritic polyethylenes (dPE) can be used as processability additives to provide extensional hardening in low concentrations in various conventional polyethylenes (PEs) such as HDPE, LLDPE and mLLDPE.2013-07-04
20130172494POLYIMIDE PRECURSOR COMPOSITION AND PREPARATION METHOD AND USE THEREOF - The present invention provides a polyimide precursor composition comprising a polyimide precursor and a thermal base generator having the structure of formula (1):2013-07-04
20130172495FUEL PART - This invention relates to a fuel part, comprising a polymer composition comprising at least 1 wt % with respect to the total weight of polymer in the polymer composition of a component A, being an aliphatic, semi-crystalline, polyamide which has as building blocks diamines with at least 2 carbon atoms and at most 5 carbon atoms and diacids with at least 10 carbon atoms. The invention also relates to a process for preparation of such fuel part.2013-07-04
20130172496HIGH REFRACTIVE INDEX COMPOSITIONS CONTAINING RESIN-LINEAR ORGANOSILOXANE BLOCK COPOLYMERS - Solid compositions of organosiloxane block copolymers are disclosed having a refractive index greater than 1.5. The organosiloxane block copolymers comprise: 40 to 90 mole percent disiloxy units of the formula [R2013-07-04
20130172497CATALYST COMPOSITIONS FOR THE POLYMERIZATION OF OLEFINS - Catalyst compositions containing N,N-bis[2-hydroxidebenzyl]amine transition metal compounds are disclosed. Methods for making these transition metal compounds and for using such compounds in catalyst compositions for the polymerization of olefins also are provided.2013-07-04
20130172498CATALYST SYSTEMS FOR PRODUCTION OF ALPHA OLEFIN OLIGOMERS AND POLYMERS - Catalyst compositions containing N,N-bis[2-hydroxidebenzyl]amine transition metal compounds are disclosed. Methods for making these transition metal compounds and for using such compounds in catalyst compositions for the polymerization or oligomerization of alpha olefins also are provided.2013-07-04
20130172499PROCESS FOR THE PREPARATION OF OLEFIN POLYMERS IN THE PRESENCE OF CHROMIUM CATALYSTS - A process for the polymerization of olefin carried out in the presence of a Cr-oxide supported catalyst and a cocatalyst the improvement comprising polymerizing in the presence of an effective amount of hydrogen thereby obtaining an increased catalyst activity.2013-07-04
20130172500Passivated Supports for Use with Olefin Polymerization Catalysts - A phosphinimine catalyst immobilized on a passivated inorganic oxide support, had high activity at low co-catalyst concentrations and gave, under gas phase polymerization conditions, ethylene copolymer with a high molecular weight. A method of making a passivated silica support involves treatment of silica with an organoaluminum compound, a diorganomagnesium compound and a source of chloride (to make MgCl2013-07-04
20130172501POLYMER FOR OPTICAL FILM, METHOD OF PREPARING SAME, AND OPTICAL FILM INCLUDING SAME - A polymer for an optical film that includes a repeating unit A including a repeating unit represented by the following Chemical Formula 1; and a repeating unit B including a repeating unit represented by the following Chemical Formula 2,2013-07-04
20130172502FLUORINE-CONTAINING COPOLYMER - Disclosed is a fluorine-containing copolymer comprising a copolymer of a polyfluoroalkyl alcohol(meth)acrylic acid derivative represented by the general formula:2013-07-04
20130172503OPTICAL FILM AND DISPLAY DEVICE INCLUDING SAME - An optical film including a polymer including a repeating unit A including a repeating unit represented by the following Chemical Formulas 1 to 3, or a combination thereof; and a repeating unit B derived from a monomer having an unsaturated bond copolymerizable with the repeating unit A, wherein the optical film has a short wavelength dispersion of an in-plane phase-difference value (R2013-07-04
20130172504SILICONE HYDROGEL MATERIALS WITH CHEMICALLY BOUND WETTING AGENTS - The invention provide a new class of silicone-containing prepolymers containing ethylenically unsaturated groups and latent UV-activated free radical generating moieties. This class of silicone-containing prepolymer is capable of being actinically crosslinked in the presence of one or more hydrophilic vinylic monomers to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and a vinylic monomer having a latent UV-activated free radical generating moiety.2013-07-04
20130172505SYNTHESIS METHOD OF POLYCARBOXYLIC ACID WATER-REDUCING AGENT - A method for synthesizing concrete polycarboxylic acid water-reducing agent at room temperature under non-stirring situation is disclosed, which comprises dissolving reactive materials, initiator, chain transfer agent and promoter into a solvent, reacting on standing at 0-50° C.; then adding neutralizing agent at the end of reaction. The method makes use of oxidation-reduction system reacting at low temperature, and can adapt to a variety of reactive material monomers. It does not need to control feeding speed or provide extra heating, does not need to stir during the reaction, and remarkably simplifies operation steps in traditional process, which makes it possible to not only produce in large scale, but also produce in small scale in concrete construction site at any moment.2013-07-04
20130172506AMINO GROUP-CONTAINING POLYMER, METHOD FOR PRODUCING THEREOF, AND DETERGENT COMPOSITION - The present invention aims to provide an amino group-containing polymer that is excellent in anti-soil redeposition property during washing and compatibility with surfactants, a method for producing thereof, and a detergent composition containing the amino group-containing polymer. The present invention is the amino group-containing polymer comprising a structural unit derived from an amino group-containing monomer having a specific structure and a structural unit derived from a nonionic monomer and/or an amino group-containing monomer other than the amino group-containing monomer described above.2013-07-04
20130172507ROTARY SPEED DETECTION METHOD AND DEVICE THEREFOR, REACTION LIQUID VISCOSITY DETECTION METHOD AND DEVICE THEREFOR, AND METHOD FOR MANUFACTURING REACTION PRODUCT - The method for detecting rotary speed includes: a step (I) for deeming the difference between input power (P) and loss power (A) to be a first order approximation value (PM2013-07-04
20130172508FLUORENE-CONTAINING ORGANIC SEMICONDUCTOR MATERIAL, PREPARATION METHOD AND USE THEREOF - A fluorene-containing organic semiconductor material, preparation method and use thereof are provided. Said fluorene-containing organic semiconductor material has the following formula (P), wherein n is an integer of 1-100; m is an integer of 1-20; x and y are positive real number, and x+y=1; R2013-07-04
20130172509Methods of Producing Microfabricated Particles for Composite Materials - Microfabricated particles are dispersed throughout a matrix to create a composite. The microfabricated particles are engineered to a specific structure and composition to enhance the physical attributes of a composite material. The microfabricated particles are generated by forming a profile extrudate. A profile extrudate is an article of indefinite length that has a cross sectional profile of a desired structure with micro-scale dimensions. Upon or after formation, the profile extrudate may be divided along its length into a plurality of microfabricated particles.2013-07-04
20130172510PROCESS FOR THE MANUFACTURE OF SILICONE IONOMER - A process for the manufacture of polyorganosiloxanes having ionic groups and reactive functional groups includes (a) conversion of a low molecular weight aralkylene modified polysiloxane to a corresponding sulfonic acid functional material by treating the low molecular weight aralkylene modified polysiloxane with a sulfonating agent; (b) subjecting the reaction product obtained in step (a) to an equilibration reaction with an acid catalyzed ring opening polymerization-effective polyorganosiloxane; and (c) subjecting the reaction product obtained in step (b) to a hydrosilylation reaction with an unsaturated hydrocarbon containing at least one epoxy group, an unsaturated hydrocarbon containing at least two unsaturation moieties, an unsaturated hydrocarbon containing at least one sulfur heteroatom, an unsaturated hydrocarbon containing a monovalent organosilane group, an unsaturated hydrocarbon containing one hydroxyl containing group, an unsaturated hydrocarbon containing one or more of a halogen, carboxylate, imine, isocyanate, amide, nitrile or tertiary amine with other than alkyl groups moiety.2013-07-04
20130172511BLOCK COPOLYMERS ON THE BASIS OF (METH)ACRYLATE - The invention relates to block copolymers produced by means of controlled polymerization and that have at least one block A or B comprising (meth)acrylate monomers and copolymerizable monomers, and a block P on the basis of functionalized polymers.2013-07-04
20130172512BIO-BASED POLYURETHANE ARTICLE - A polyurethane article includes at least 25% of bio-based content and is made of a reactive composition containing an isocynate compound, a polymeric polyol component including biomass derived polymeric polyol, and a biomass derived diol.2013-07-04
20130172513POLYIMIDES - Disclosed is a polyimide polymerized by x molar parts of a first diamine, y molar parts of a second diamine, and 100 molar parts of a first dianhydride, wherein the first diamine has a formula of2013-07-04
20130172514"PROCESS FOR PRODUCING CYCLOALKYLAROMATIC COMPOUNDS" - In a process for producing a cycloalkylaromatic compound, an aromatic compound, hydrogen and at least one diluent are supplied to a hydroalkylation reaction zone, such that the weight ratio of the diluent to the aromatic compound supplied to the hydroalkylation reaction zone is at least 1:100. The aromatic compound, hydrogen and the at least one diluent are then contacted under hydroalkylation conditions with a hydroalkylation catalyst in the hydroalkylation reaction zone to produce an effluent comprising a cycloalkylaromatic compound.2013-07-04
20130172515BIAXIALLY ORIENTED POLYESTER FILM AND LINEAR MAGNETIC RECORDING MEDIUM - A biaxially oriented polyester film has a ratio of Young's modulus in the transverse direction to Young's modulus in the machine direction of 1.5 to 3, an average value of refractive indices in the machine direction, in the transverse direction, and in the thickness direction of 1.590 to 1.680, a minor melting peak temperature of 160 to 190° C., and a coefficient of hygroscopic expansion in the transverse direction of 0 to 6 ppm/% RH.2013-07-04
20130172516POLYESTER FIBER AND METHOD FOR PRODUCING SAME - Disclosed is a high strength and high elongation polyester fiber being used for anchoring, mooring, or towing a ship, and particularly is a polyester fiber wherein the recovered work ratio at the elongation corresponding to 10% of the maximum load measured at room temperature is 70% or more, the recovered work ratio at the elongation corresponding to 20% of the maximum load is 50% or more, and the recovered work ratio at the elongation corresponding to 30% of the maximum load is 40% or more, a method of preparing the same, and a polyester fiber rope including the same.2013-07-04
20130172517PREPARATION OF LOW MOLECULAR WEIGHT POLYORNITHINE IN HIGH YIELD - The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons.2013-07-04
20130172518FLEXIBLE MALEIMIDE POLYMER AND METHOD FOR PREPARING THE SAME - Disclosed is a flexible maleimide polymer. The flexible maleimide polymer includes a reaction product of reactants (a)-(c). The reactant (a) is maleimide, a compound with a structure represented by Formula (I), a compound with a structure represented by Formula (II), or combinations thereof2013-07-04
20130172519PROCESSES FOR PRODUCING DIAMINOBUTANE (DAB), SUCCINIC DINITRILE (SDN) AND SUCCINAMIDE (DAM) - Processes that make nitrogen-containing compounds include converting succinic acid (SA) or monoammonium succinate (MAS) derived from a diammonium succinate (DAS)- or MAS-containing fermentation broth to produce such compounds including diaminobutane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN), succinamide (DAM), and related polymers.2013-07-04
20130172520POLYOXAMIDE RESIN HAVING EXCELLENT IMPACT RESISTANCE AND IMPACT-RESISTANT PART - Provided is a polyoxamide resin which has excellent impact resistance and is characterized in that the polyoxamide resin is obtained from a diamine in which the diamine component has 10 to 18 carbons and in that the polyoxamide resin has a relative viscosity (ηr) of 2.1 or greater as determined at 25° C. using 96% sulfuric acid as a solvent and a solution having a concentration of 1.0 g/dL, and also provided is an impact-resistant part comprising this resin. The polyoxamide resin has a higher molecular weight than a conventional polyoxamide resin, a large moldable temperature range as estimated from the difference between the melting point and the thermal decomposition temperature and therefore excellent molten moldability, and furthermore excellent impact resistance when compared to a conventional aliphatic polyoxamide resin without losing the low water absorbency, chemical resistance, hydrolysis resistance, high elasticity, and high strength seen with aliphatic straight-chain polyoxamide resins.2013-07-04
20130172521METHOD FOR PRODUCING NYLON SALT POWDER, AND METHOD FOR PRODUCING NYLON - Disclosed is a method for producing a nylon salt powder, wherein in the production of a nylon salt powder by allowing a dicarboxylic acid powder to react, the content of water is regulated to be 5% by mass or less in relation to the total amount of the dicarboxylic acid powder and a diamine, the dicarboxylic acid powder is beforehand heated to a temperature equal to or higher than melting point of the diamine and equal to or lower than the melting point of the dicarboxylic acid, and while this heating temperature is being maintained, the diamine is added to the dicarboxylic acid powder in such a way that the dicarboxylic acid powder maintains the condition of being in powder form.2013-07-04
20130172522EPOXY COMPOUND WITH NITROGEN-CONTAINING RING - There is provided an epoxy compound that provides properties of cured products combining high transparency with high flexural strength by being thermally cured while maintaining advantageous handling properties in a liquid state thereof. An epoxy compound of Formula (1):2013-07-04
20130172523METHOD FOR PRODUCING COPOLYMER OF DIALLYLAMINE AND SULFUR DIOXIDE - Provided is a process for producing a copolymer of a diallylamine and sulfur dioxide which copolymer has a higher molecular weight and water-solubility than that obtained by a conventional production process by copolymerizing the diallylamine and sulfur dioxide in the presence of an acid and a radical polymerization initiator in a polar solvent.2013-07-04
20130172524CATALYSTS AND METHODS FOR POLYMER SYNTHESIS - The present invention provides bimetallic complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to one or more active metal centers of the complex.2013-07-04
20130172525METHOD FOR PRODUCING EPOXY COMPOUND HAVING CYANURIC ACID SKELETON - There is provided an epoxy compound that provides properties of cured products combining high transparency with high flexural strength by being thermally cured while maintaining advantageous handling properties in a liquid state thereof; and a method for producing a composition by using the epoxy compound. A method for producing an epoxy compound of Formula (1):2013-07-04
20130172526WOOD TREATMENT METHOD AND APPARATUS EMPLOYING LATERALLY SHIFTABLE TRANSPORTATION SEGMENTS - A wood treatment method and apparatus that includes a laterally shiftable transportation segment adjacent a door of a wood treatment vessel. When retracted, the shiftable transportation segment accommodates the opening and/or closing of the door. When aligned, the shiftable transportation segment can support the weight of a cart that transports a bundle of wood into and/or out of the wood treatment vessel. Wood treatment systems described herein may also include a bundle adjustment system for applying an aligning force to at least a portion of the bundle during its loading and/or unloading from the wood treatment vessel.2013-07-04
20130172527PROCESS FOR OBTAINIING TALL OIL FROM A SODIUM SESQUISULFATE SOLUTION - The invention relates to a process for producing tall oil by reacting tall oil soap with a sodium sesquisulfate solution. The process includes the following steps: a) Determining the concentration of sodium sesquisulfate; b) Reaction between sodium sesquisulfate solution and tall oil soap; e) Separating tall oil and brine phases.2013-07-04
20130172528DALBAVANCIN COMPOSITIONS FOR TREATMENT OF BACTERIAL INFECTIONS - The invention provides methods for drying dalbavancin. The method includes providing wet dalbavancin that includes dalbavancin, water, and a solvent. The wet dalbavancin is dried at at a temperature of about 30° C. or less, at a vacuum pressure of about 50 mbar or less, until the water level of the wet dalbavancin is less than about 20% (w/w). Water is then added to the dalbavancin and the resulting wet dalbavancin is dried at least once more at a temperature of about 30° C. or less, at a vacuum pressure of about 50 mbar or less, until the solvent level of the dalbavancin is less than about 3.0% (w/w).2013-07-04
20130172529METHOD FOR SYNTHESIZING THYMOSINS - The invention relates to a method for obtaining thymosins and/or the pharmaceutically acceptable salts thereof by means of solid-phase synthesis on polymeric supports, which comprises the steps of linearly synthesizing the thymus-derived peptides in solid phase, incorporating at least one Thr or Ser in the sequence, in pseudoproline dipeptide form, obtaining the thymosins by treating the peptidyl resin with trifluoroacetic acid, and purifying the thymosins by RP-HPLC. The present invention also protects the isolated and/or purified compound obtained by means of said method and also the use thereof in the preparation of a medicinal product.2013-07-04
20130172530Novel JNK Inhibitor Molecules - The present invention relates to novel JNK inhibitor molecules. The present invention furthermore relates to methods for raising antibodies against such JNK inhibitor molecules as well as to the respective antibodies and cells producing said antibodies.2013-07-04
20130172531HUMAN PLACENTAL COLLAGEN COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME - The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.2013-07-04
20130172532METHOD FOR MAKING RHENIUM-186/188 LABELED HUMAN SERUM ALBUMIN MICROSPHERES AND KIT FOR MAKING THE SAME AND METHOD FOR USING THE KIT - The present invention relates to a method for preparing 2013-07-04
20130172533HUMANIZED ANTI-HUMAN CD34 MONOCLONAL ANTIBODY AND USES THEREOF - A novel humanized antibody against the CD34 surface antigen on the human stem cells is provided. The humanized antibody contains a heavy chain variable region comprising an amino sequence as set forth in SEQ ID No. 1 and a light chain variable region comprising an amino sequence as set forth in SEQ ID No. 2. The disclosure also provides the applications of the disclosed humanized antibody.2013-07-04
20130172534ANTIBODIES TO OX-2/CD200 AND USES THEREOF - This application provides methods and compositions for modulating and/or depleting CD200 positive cells.2013-07-04
20130172535PROCESS FOR PROTEIN EXTRACTION - The invention includes a process for extracting a target protein from 2013-07-04
20130172536Intravenous Cytomegalovirus Human Immune Globulin and Manufacturing Method Thereof - The present invention discloses an intravenous cytomegalovirus human immune globulin and a manufacturing method thereof, wherein the technical problem to be solved is to improve the purity, yield, and safety of the product. The intravenous cytomegalovirus human immune globulin of the present invention has a specific activity of no less than 2.5 PEI-U/mg, an anti-CMV titer of no less than 100 PEI-U/ml, a purity of greater than 98.2%, and a protein content of 51˜55 mg/ml. The present invention employs caprylic acid precipitation and anion exchange chromatography for replacing the step of ethanol precipitation in the conventional cold ethanol method to keep IgG in the supernatant and maintain the activity of the IgG; the present invention employing processes of caprylic acid inactivation of virus and nanometer film virus removal can effectively protect the safety of the product, and studies show that the preparing method of the present invention not only improves the purity, yield, and safety of the product; but also saves energy and reduces the cost of production.2013-07-04
20130172537REDUCTION OF ENDOTOXIN IN POLYSIALIC ACIDS - The present invention relates to process for reducing the endotoxin content of a sample of fermentation broth containing polysialic acid and endotoxin comprising the sequential steps: (i) adding to the sample a base having a pKa of at least 12 to form a basic solution having a pH of at least 12, incubating the solution for a pre-determined time at a pre-determined temperature; and (ii) recovery of PSA, suitably by (iii) passing the sample through an anion-exchange column whereby polysialic acid is absorbed on the ion exchange resin; (iv) washing the column with one washing buffer, whereby polysialic acid remains absorbed on the ion exchange resin; and (v) eluting the polysialic acid from the column using an elution buffer to provide a product solution of polysialic acid having reduced endotoxin content.2013-07-04
20130172538METHOD FOR PRODUCING POROUS PARTICLES, POROUS PARTICLES, ADSORBENT BODY, AND METHOD FOR PURIFYING PROTEIN - The objective of the present invention is to provide a method for easily producing a porous cellulose particle which can be used as an adsorbent for various substances in a safe manner without using a highly toxic solvent such as a calcium thiocyanate solution. In addition, the objective of the present invention is to provide a porous particle produced by the production method, an adsorbent which contains the porous particle and by which a highly pure protein can be efficiently purified in a safe manner, and a method for purifying a protein by using the adsorbent. The method for producing a porous particle according to the present invention is characterized in comprising the steps of preparing a solution containing cellulose and an ionic liquid; preparing a dispersion by dispersing the obtained cellulose solution into a liquid, wherein the liquid is not compatible with the ionic liquid; and coagulating the dispersion by bringing into contact with an alcohol or an alcohol aqueous solution in order in order to obtain the porous particle.2013-07-04
20130172539METHODS AND COMPOSITIONS OF PREPARATION FOR PROTEOME ANALYSIS - A method of extracting a polypeptide from a biological sample includes contacting the biological sample with an extraction reagent to form a solution of the biological sample and the extraction reagent. The extraction reagent includes perfluorooctanoic and can be used at a concentration effective to solubilize the polypeptides in the biological sample.2013-07-04
20130172540Compositions Comprising Lignin - Compositions comprising lignin and low levels of undesirable impurities, such as compounds containing sulfur, nitrogen, or metals, are disclosed.2013-07-04
20130172541METHOD FOR PREPARING AN EXTRACT OF CENTELLA ASIATICA - The invention relates to a method for preparing a refined extract of 2013-07-04
20130172542HYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PARTICULATE COMPOSITION COMPRISING THE SAME, THEIR PREPARATION AND USES - The present invention has objects to provide a novel crystalline 2-O-α-glucosyl-L-ascorbic acid and its production process and uses, and solves the above objects by providing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, a particulate composition containing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, and their production processes and uses.2013-07-04
20130172543METHOD FOR OXIDIZING ALCOHOLS - A method for oxidizing an alcohol, wherein oxidation is performed in the presence of a compound represented by the following formula (I) and a bulk oxidant, which enables efficient oxidation of secondary alcohols as well as primary alcohols, and can attain high reaction efficiency even when air is used as a bulk oxidant.2013-07-04
20130172544NANO-DEAGGREGATED CELLULOSE - Disclosed are methods and systems for treating cellulose to make it more accessible for enzymatic or chemical modification. The invention includes treating cellulose with an alkali in an alcohol/water co-solvent system. The treatment decrystallizes or deaggregates the cellulosic material. The methods and systems increase the efficiency of enzymatic or chemical modifications of cellulose for use as biofuels or cellulose derivatives.2013-07-04
20130172545SUPERHYDROPHILIC AMPHIPHILIC COPOLYMERS AND PROCESSES FOR MAKING THE SAME - A superhydrophilic amphiphilic copolymer and process for making the superhydrophilic amphiphilic copolymer includes a low molecular weight polysaccharide modified with a hydrophobic reagent, such as substituted succinic anhydride. The superhydrophilic amphiphilic copolymer system generates stable foam for use in applications, such as healthcare formulations, with low irritation of the eyes and skin.2013-07-04
20130172546COMPOSITIONS COMPRISING C5 AND C6 OLIGOSACCHARIDES - Compositions comprising C5 and C6 saccharides of varying degrees of polymerization and low levels of undesirable impurities, such as compounds containing sulfur, nitrogen, or metals, are disclosed.2013-07-04
20130172547COMPOSITIONS COMPRISING C5 AND C6 OLIGOSACCHARIDES - Compositions comprising C5 and C6 saccharides of varying degrees of polymerization and low levels of undesirable impurities, such as compounds containing sulfur, nitrogen, or metals, are disclosed.2013-07-04
20130172548DERIVATIZATION OF OLIGOSACCHARIDES - A method for purifying, separating and/or isolating an oligosaccharide or a salt thereof is presented. An embodiment of the invention is based upon the formation of anomeric O-benzyl/substituted O-benzyl derivatives in a selective anomeric alkylation reaction.2013-07-04
20130172549Heteroaryl amide derivatives - Heteroaryl amide derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.2013-07-04
20130172550P2X4 RECEPTOR ANTAGONIST - A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X2013-07-04
20130172551Process for Preparing Carbamolypyridone Derivatives and Intermediates - The present invention relates to the preparation of carbamoylpyridone derivatives and intermediates.2013-07-04
20130172552Novel Small-Molecule Inhibitors of Rac1 in Metastatic Breast Cancer - A novel inhibitor of Rac activity based on the structure of the established Rac/Rac-GEF inhibitor NSC23766 is discloses. The compound EHop-016, with an IC50 of 1.1 μM, is a 100-fold more efficient inhibitor of Rac activity than NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations ≦5 mM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42. In MDA-MB-435 cells, EHop-016 (≦5 mM) inhibits the association of the Rac-GEF Vav2 with a nucleotide-free Rac1(G15A), which has a high affinity for activated GEFs. EHop-016 does not affect the association of the Rac-GEF Tiam-1 with Rac1(G15A) at similar concentrations. EHop-016 also inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines. EHop-016 decreases Rac-downstream effects of p21-activated kinase (PAK)1 activity and directed migration of metastatic cancer cells. At low concentrations (<5 μM), EHop-016 does not affect cell viability.2013-07-04
20130172553CHIRAL SYNTHESIS OF ISOXAZOLINES, ISOXAZOLINE COMPOUNDS, AND USES THEREOF - Processes for the chiral syntheses of isoxazolines and intermediates are described. Compounds prepared thereby, and methods of using the compounds are also described.2013-07-04
20130172554PROCESSES FOR THE PREPARATION OF 4-MORPHOLIN-3-ONE - The present invention provides processes for the preparation of 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one which are simple, eco-friendly, cost-effective, reproducible, robust and are well amenable on industrial scale.2013-07-04
20130172555Horizontal High-Pressure Melamine Reactor - A high-pressure melamine reactor is provided. The high-pressure melamine reactor comprising at least one horizontal reactor body having a bottom and a top side with at least one dome integrally formed on the top side of the reactor body. The at least one horizontal reactor body comprises at least two compartments separated by at least one baffle, in particular an overflow baffle. The at least one dome is solely located above at least one of the compartments serving as melamine synthesis unit, wherein the at least one compartment serving as melamine synthesis unit comprises at least one heating element.2013-07-04
20130172556METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF - The present invention relates to a novel method for producing a pyridazinone compound and an intermediate thereof as shown in the following scheme: wherein the symbols are as defined in the specification.2013-07-04
201301725572,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE- CARBALDEHYDES, AND METHODS OF FORMATION AND USE - 2,6-Dihalo-5-alkoxy-4-substituted-pyrimidines, 2,6-dihalo-5-alkoxy-4-pyrimdine carbaldehydes, and derivatives of each are useful intermediates in forming potent herbicides that demonstrate a broad spectrum of weed control. These compounds are disclosed, as are methods of forming and using these compounds.2013-07-04
20130172558NAPROXEN-BASED CHIRAL COMPOUNDS AND LIQUID CRYSTAL DISPLAY APPLICATIONS - Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compounds, which can be used in liquid crystal compositions useful for electro-optical and display device applications. The liquid crystal can be a ferroelectric liquid crystal. Also provided is a display device that includes the Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compound. Also provided is a method of preparing a liquid crystal display device on silicon that includes incorporating the Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compound, into a liquid crystal display on silicon by disposing the compound in a liquid crystal, or the liquid crystal, onto a silicon surface.2013-07-04
20130172559POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY - The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof.2013-07-04
20130172560PROCESSES FOR MAKING CYCLOPROPYL AMIDE DERIVATIVES AND INTERMEDIATES ASSOCIATED THEREWITH - Presented herein are processes for making cyclopropyl amide derivatives of formula I, and/or pharmaceutically acceptable salts thereof, and intermediates associated therewith. At least one cyclopropyl amide derivative of formula I, or pharmaceutically acceptable salt thereof is useful to treat at least one histamine H3 receptor associated condition.2013-07-04
20130172561SYNTHESIS OF CYCLOMETALLATED PLATINUM(II) COMPLEXES - A single-step method of making tetradentate platinum or palladium complexes is disclosed. The method advantageously allows the formation of a platinum or palladium complex in a single step, even with sterically hindered ligands, without the use of highly reactive intermediates. The compounds made by the disclosed method are useful in OLED applications.2013-07-04
20130172562PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE - A process comprising: (a) reduction of N-acetyl-3-aminopyridine (2): or its salt in the presence of hydrogen and a palladium catalyst deposited on solid support; (b) converting racemic N-acetyl-3-aminopiperidine (3) or its salt produced in step (a) to rac-3-aminopiperidine (rac-4) or its salt; (c) resolution of the racemic 3-aminopiperidine (rac-4) or its salt produced in step (b) with a chiral acid.2013-07-04
20130172563LENALIDOMIDE SOLVATES AND PROCESSES - The present application relates to lenalidomide salts and solvates, and processes for the preparation thereof.2013-07-04
20130172564PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF - The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I):2013-07-04
20130172565METHODS OF FORMING 4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC ACID PINACOL ESTERS AND METHODS OF USING THE SAME - Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate. The (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate is reacted with an acid to form a 4 chloro-2-fluoro-3-substituted-phenylboronic acid. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is reacted with 2,3-dimethyl-2,3-butanediol to form 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters to produce 6-(4-chloro-2-fluoro-3-substituted-phenyl)-4-aminopicolinates are also disclosed.2013-07-04
20130172566METHODS OF PRODUCING METHYL 4-AMINO-3-CHLORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PYRIDINE-2-CARBOXYL- ATE - Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. One method comprises adding methyl isobutyl ketone to an aqueous solution comprising 4-chloro-2-fluoro-3-methoxyphenyl-boronic acid to form an organic phase comprising the 4-chloro-2-fluoro-3-methoxyphenylboronic acid and an aqueous phase. The organic phase and the aqueous phase are separated. The 4-chloro-2-fluoro-3-methoxyphenylboronic acid is reacted with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate in methyl isobutyl ketone to produce methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate, which is deacetylated to produce methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate.2013-07-04
20130172567METHODS OF ISOLATING (4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYL)BORONATES AND METHODS OF USING THE SAME - Methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate include adding carbon dioxide gas or carbon dioxide solid (dry ice) to a solution comprising a 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt to react the at least one lithium salt with the carbon dioxide gas or carbon dioxide solid (dry ice) and form a mixture comprising the 4-chloro-2-fluoro-3-substituted-phenylboronate, the inert organic solvent, and a precipitated solid. The precipitated solid may be removed from the mixture. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronates to produce methyl-4-amino-3-chloro-6-(4-chloro-2-fluoro-3-substituted-phenyl)pyridine-2-carboxylates are also disclosed. A 4-chloro-2-fluoro-3-substituted-phenylboronate produced by one of the methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate is also disclosed, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronate may be obtained at a yield of greater than or equal to about 90%.2013-07-04
20130172568Chelating Carbene Ligand Precursors and Their Use in the Synthesis of Metathesis Catalysts - Chelating ligand precursors for the preparation of olefin methathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various methathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene methathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type methathesis catalysts. The invention provides an efficient method for preparing chelating-carbene metathesis catalysts by reacting a suitable ruthenium complex in high concentrations of the ligand precursors followed by crystallization from an organic solvent.2013-07-04
20130172569BASE GENERATOR - The present invention provides a base generator having the structure of formula (1):2013-07-04
20130172570METHOD OF MAKING BENZAZOLES - This present invention provides a method of making benzazoles comprising a process of making aryl or alkyl benzazoles from corresponding aryl acid chlorides or alkyl acid chlorides without applying hazard condensing agent. The benzazole compounds described in this invention have following formula I:2013-07-04
20130172571PROCESS TO PREPARE ETHYL 4-METHYL-2-(4-(2-METHYLPROPYLOXY)-3-CYANOPHENYL)-5-THIAZOLECARBOXYLATE - Disclosed is a process for the preparation of Ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate (I) the key intermediate for the preparation of [2-[3-cyano-4-(2-Methyl-propoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (Febuxostat, I(A)) is approved under the trademark Uloric® by the US Food and Drug Administration for the treatment of hyperuricemia and gouty arthritis.2013-07-04
20130172572Process for Manufacture of N-acylbiphenyl alanine - A novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.2013-07-04
20130172573Process for Preparing Chiral 3-Triazolyl Sulphoxide Derivatives - The present invention relates to a catalytic process for preparing 3-triazolyl sulphoxide derivatives in enantiomerically pure or enantiomerically enriched form.2013-07-04
20130172574METHOD FOR MANUFACTURING HYDROPHILIC SILICONE MACROMER - A method for manufacturing a hydrophilic silicone macromer is provided. A hydrosilylation between a Si—H bond of a polysiloxane and a C═C bond of a hydrophilic mononmer is performed by using a rhodium-containing catalyst to form the polysiloxane having a hydrophilic side chain having an amide group or a phosphoryl choline group. After performing an end-capping reaction, the hydrophilic silicone macromer is formed.2013-07-04
20130172575Pyrrolopyrrole derivatives, their manufacture and use - The present invention relates to compounds of the formula I2013-07-04
20130172576BRANCHED HETERO POLYFUNCTIONAL POLYOXYALKYLENE COMPOUND AND INTERMEDIATE THEREOF - A branched hetero polyfunctional polyoxyalkylene compound represented by the following formula (1):2013-07-04
20130172577PROCESS FOR PRODUCING A RINGLIKE OXIDIC SHAPED BODY - A process for producing a ringlike oxidic shaped body by mechanically compacting a pulverulent aggregate introduced into the fill chamber of a die, wherein the outer face of the resulting compact corresponds to that of a frustocone.2013-07-04
20130172578PROCESS FOR PREPARING 1, 6-HEXANEDIOL - Disclosed are processes for preparing 1,6-hexanediol and synthetic intermediates useful in the production of 1,6-hexanediol from renewable biosources. In one embodiment, a process comprises contacting levoglucosenone with hydrogen in the presence of a first hydrogenation catalyst at a first temperature to form product mixture (I); and heating product mixture (I) in the presence of hydrogen and a second hydrogenation catalyst at a second temperature to form product mixture (II) which comprises 1,6-hexanediol.2013-07-04
20130172579PROCESS FOR THE PRODUCTION OF HEXANEDIOLS - Disclosed are processes for preparing 1,2-cyclohexanediol, and mixtures of 1,2-cyclohexanediol and 1,6-hexanediol, by hydrogenating 1,2,6-hexanetriol.2013-07-04
20130172580PRODUCTION OF HYDROXYMETHYLFURFURAL FROM LEVOGLUCOSENONE - Disclosed are processes comprising contacting an aqueous reaction mixture having an initial pH between about 3 and about 6 and comprising levoglucosenone with a catalyst, and heating the reaction mixture to form a product mixture comprising 5-hydroxymethyl-2-furfural. The processes may further comprise heating the product mixture comprising 5-hydroxymethyl-2-furfural in the presence of hydrogen and a hydrogenation catalyst to form a second product mixture comprising one or more of 2,5-furandimethanol, tetrahydrofuran 2,5-dimethanol, 1,2,6-hexanetriol, 2-hydroxymethyltetrahydropyran, and 1,6-hexanediol.2013-07-04
20130172581PROCESS FOR THE PRODUCTION OF FURFURAL - Furfural is produced by mixing an aqueous feedstock solution containing C2013-07-04
20130172582PROCESSES FOR MAKING FURFURALS - Processes for making furfural and 5-hydroxymethylfurfural from sugars are provided. The processes can be carried out using a batch process or a continuous mode of operation. An aqueous sugar solution is pressurized with CO2013-07-04
20130172583PROCESS FOR THE PRODUCTION OF FURFURAL - Furfural is produced by contacting a feedstock solution containing C2013-07-04
20130172584PROCESS FOR THE PRODUCTION OF FURFURAL - Furfural is produced by mixing an aqueous feedstock solution containing C2013-07-04
20130172585PROCESS FOR THE PRODUCTION OF FURFURAL - Furfural is produced by contacting an aqueous feedstock solution containing C2013-07-04
20130172586PRODUCTION OF TETRAHYDROFURAN-2, 5-DIMETHANOL FROM ISOSORBIDE - Disclosed herein are processes comprising contacting isosorbide with hydrogen in the presence of a first hydrogenation catalyst to form a first product mixture comprising tetrahydrofuran-2,5-dimethanol. The processes can further comprise heating the first product mixture in the presence of hydrogen and a second hydrogenation catalyst to form a second product mixture comprising 1,6-hexanediol. The first and second hydrogenation catalysts can be the same or different.2013-07-04
20130172587Process for the Preparation of Fluticasone Propionate - The present invention relates to a process for the preparation of steroidal 17β-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17β-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.2013-07-04
20130172588CONTINUOUS PHOTOLYTIC PROCESS FOR THE PREPARATION OF VITAMIN D RELATED SUBSTANCES - The present application provides a novel method for generation of a vitamin D2 compound using a continuous flow photoisomerization reactor. A compound represented by formula I: [structure] as further defined herein, is mixed with a solvent and a sensitizer, and is then passed through the continuous flow photoisomerization reactor. If X3 and X4 of formula II is tert-butyldimethylsilyl, then formula II is mixed with a deprotection reagent to obtain the vitamin D2 analog.2013-07-04
20130172589Surface Active Agents Derived from Biodiesel-Based Alkylated Aromatic Compounds - A surface active agent comprising an arylated methyl ester of a fatty acid, or mixture of fatty acids, derived from biodiesel or a triglyceride source is disclosed. The fatty acid mixture is condensed to methyl esters and alkylated with aromatic substituents under Friedel-Crafts conditions. The alkylated methyl esters may be alkoxylated using a catalyst derived from fatty acids, alkaline earth salts, and strong acids. The resulting nonionic surfactant may also be sulfonated to produce one class of anionic surfactants. The alkylated methyl esters may also be directly sulfonated to produce another class of anionic surfactants.2013-07-04
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