27th week of 2013 patent applcation highlights part 44 |
Patent application number | Title | Published |
20130171586 | METAL STRUCTURE THAT SERVES AS AN INTERNAL SUPPORT TO A DENTAL PROSTHESIS - Metal structure that serves as an internal support to a dental prosthesis, comprising at least two support posts ( | 2013-07-04 |
20130171587 | SURGICAL GUIDE PREPARATION TOOL AND METHOD FOR PREPARING SURGICAL GUIDE - The present invention provides an inexpensive surgical guide preparation tool by which an insertion hole for implant can be correctly and easily formed at a predetermined position. | 2013-07-04 |
20130171588 | DENTURE AND ARTIFICIAL TOOTH USED IN THE DENTURE - The denture has the root of an artificial tooth embedded in a denture base molded from plastic. The artificial tooth is provided with a through-hole in the root that fills with denture base plastic, and the openings at both ends of the through-hole are embedded in the denture base. Further, both ends of the through-hole open at artificial tooth surfaces that face adjacent teeth, and an air-vent is provided that connects with the through-hole. The opening for the air-vent is positioned on a lingual side surface of the artificial tooth that is exposed from the denture base. Plastic that forms the denture base flows into the through-hole and air-vent embedding and retaining the root of the artificial tooth in the denture base. | 2013-07-04 |
20130171589 | AESTHETIC AND ABRASION RESISTANT COATED DENTAL ARTICLES AND METHODS OF MAKING THE SAME - Provided are methods of improving the wear resistance and aesthetic properties of dental articles though use of spherical microparticles, as well as dental articles having an abrasion resistant spherical microparticle/polymer coating thereon. | 2013-07-04 |
20130171590 | SYSTEM, METHOD, AND COMPUTER SOFTWARE CODE FOR INSTRUCTING AN OPERATOR TO CONTROL A POWERED SYSTEM HAVING AN AUTONOMOUS CONTROLLER - A method for training an operator to control a powered system is disclosed including operating the powered system with an autonomous controller, and informing an operator of a change in operation of the powered system as the change in operation occurs. A system and a computer software code are also disclosed for training the operator to control the powered system. | 2013-07-04 |
20130171591 | COMPUTER AIDED SYSTEM FOR TEACHING READING - A method of teaching reading includes displaying, by an application executing on a computing device, a singing exercise configured to allow a user to sing along as a song is played. Lyrics of the song are displayed as the song plays, thus allowing the user to read the lyrics as the user sings along to the song. An audio input is monitored as the song is played. A score representing how accurately the audio input matches the song is calculated. The score is provided to the user. The method calculates the user's vocal range and uses that vocal range in generating a score. | 2013-07-04 |
20130171592 | Method and System for Presenting Interactive, Three-Dimensional Tools - A system includes an education module ( | 2013-07-04 |
20130171593 | SYSTEMS AND METHODS FOR ENCOURAGING REGULAR PARTICIPATION IN TRAINING AND COLLABORATIVE ACTIVITIES THROUGH A GAMIFIED TRAINING PLATFORM - Systems and methods for encouraging regular participation in training and collaborative activities by employees of an organization are provided through a gamified training platform. Preferably, these systems and methods are implemented in an Internet based environment accessed by the employees from various types of mobile devices. A training activity is determined based on training modules pertaining to the organization and made accessible to the employees for a specified period. When a first employee performs the training activity, the platform generates a collaborative review activity that allows other employees to review the first employee's training performance. When a second employee performs the collaborative review activity, the platform generates a collaborative feedback activity that allows yet other employees to rate the second employee's review. In certain embodiments, the platform may generate a leaderboard displaying the relative ranking of the employees based on the employees' performance of the training and collaborative activities. | 2013-07-04 |
20130171594 | SYSTEMS AND METHODS FOR PROVIDING TRAINING AND COLLABORATIVE ACTIVITIES THROUGH A GROUP-BASED TRAINING AND EVALUATION PLATFORM - Systems and methods are provided for allowing users associated with an organization to participate in training and collaborative activities through a gamified training platform. Preferably, these systems and methods are implemented in an Internet based environment that can be accessed from various types of mobile devices. A training activity is determined based on training data pertaining to the organization and made accessible to the users through the platform. When users perform the training activity, the platform generates collaborative review activities that allow other users to review the users' performance of the training activity. In certain embodiments, when other users perform the collaborative review activities, the platform generates collaborative feedback activities that allow still other users to rate the users' performance of the collaborative review activities. In certain embodiments, a leaderboard is made accessible to the users based on the users' performance of training and collaborative activities through the platform. | 2013-07-04 |
20130171595 | ROPE CONNECTING DEVICE AND METHOD - A rope connecting device and method are provided especially for use in calf roping as a rope breakaway. The device includes a stem with a first hook formed at one end, and a second hook formed at the other end. The hooks each have a small gap separating respective free ends of the hooks from the stem. During use, a portion of the rope is passed through the first hook, and another portion of the rope is passed the through the second hook. With sufficient force applied to the rope, the force causes one of the hooks to open to a degree allowing the rope to pass through, thereby releasing the rope from an object that was lassoed. The device remains attached to the rope at the other hook. The rope is configured for the next use by reattaching the portion of the rope to the hook that was released. | 2013-07-04 |
20130171596 | AUGMENTED REALITY NEUROLOGICAL EVALUATION METHOD - A system and method for neurological testing involves prompting a subject or user to engage in body and head movements, measuring physical response, and then using the measured response to evaluate the neurological condition of the subject. The subject may wear a head-mounted display, for example, to aid in prompting the head and/or body movements. The subject may be prompted to engage in movements simulating a real-world task, such as a sports-specific activity. Results may be compared with those of a baseline test. The evaluation may be used to aid in determining if the user or subject can return to the task, for example to return to activity in a sport during which the user sustained a possible neurological injury. | 2013-07-04 |
20130171597 | TRAINING TOILET - A training toilet design that can be adapted for either a dog or a cat or other animal and even for a young human child is disclosed. A space or enclosure receives the trainee and upon receipt a switch is actuated. The switch can either be a pressure actuated mechanical switch or a motion detector switch. In response to the switch changing state, a microcontroller is actuated to provide any one of a number of responses. Responses include an audible encouraging comment when the trainee exits and for when entering the toilet. A timing lapse programmed into the microprocessor can ensure that the exit message is played only when there has been a predetermined lapse time between the entrance and exit of the trainee. Modes that are provided by different combinations of these features are determined by a mode switch that is operable by the user. | 2013-07-04 |
20130171598 | Gait Restore Balls - The Gait Restore Balls unit is a rehabilitative and ambulation accessory for a walker that provides visual and auditory cues to improve the movement pattern or walking ability of an individual with gait problems caused by physiological or neurological issues. The device has two light-shimmering balls which illuminate in an alternating fashion and provides a visual target for each leg. The user than reaches for the glowing ball with their foot as they stride forward. When struck with the ankle, the Gait Restore Ball chimes a pleasing tone indicating a successful step. The unit includes two illuminating balls (one for each leg), which attach to medical tubing which is attached to the cross bars, allowing for varying stride lengths. | 2013-07-04 |
20130171599 | System and Method for Reliably Coordinating Musculoskeletal and Cardiovascular Hemodynamics - Systems and methods are disclosed to enable a user to favorably coordinate the timing of musculoskeletal movement and skeletal muscle contraction and relaxation with the cardiac pumping cycle in order to improve perfusion of cardiac and peripheral skeletal muscle and other tissues, increase physiological efficiency, decrease myocardial stress, and enhance individual performance, health and safety during rhythmic physical activity. Additionally, systems and methods are disclosed to enable a user to avoid inadvertent unfavorable coordination of musculoskeletal movement and skeletal muscle contractions and relaxation cycles with the cardiac pumping cycle during physical activity. | 2013-07-04 |
20130171600 | CENTER OF GRAVITY SHIFTING TRAINING SYSTEM - A center of gravity shifting training system includes a display device having a display screen, a measurement device configured to measure a center of gravity position of the user, and a control device. The control device has a training mode and a setting mode of preparing setting data indicating a position of the target image in the display screen. In the setting mode, the control device performs estimation of a deviation of the center of gravity position based on the center of gravity position measured, and prepares the setting data indicating the position of the target image according to a result of the estimation. In the training mode, the control device displays the operation image on the screen in accordance with the center of gravity position measured, and displays the target image on the screen based on the setting data prepared through the setting mode. | 2013-07-04 |
20130171601 | EXERCISE ASSISTING SYSTEM - The exercise assisting system includes: a display device including a display screen displaying an image to a user; a comparison image storing unit storing a comparison image representing an image of an exerciser performing a predetermined exercise; a comparison image display unit displaying the comparison image stored in the storing unit on the screen; a mirror image displaying means displaying a mirror image of the user so as to overlap the comparison image; a characteristic amount extraction unit detecting positions of sampling points of a body of the user and calculating a characteristic amount representing a posture of the user based on the position; a posture estimation unit comparing the characteristic amount from the extraction unit with a criterion amount representing a posture of the exerciser and estimating a deviation between postures of the user and the exerciser; and a presentation unit presenting an estimation result of the estimation unit. | 2013-07-04 |
20130171602 | TABLEWARE PRACTICE TOOL KIT - A tableware practice tool kit includes a combined main body formed by combining a plurality of components in an assembling way and/or in a way of stacking blocks, and forming a space for accommodating tableware. The tableware practice tool kit provides tableware and objects that are similar to shapes of different kinds of food and is convenient to carry. Therefore, the practice is not limited by the time and environment, and a person can practice using the tableware at any time in a game manner so that the person can use the tableware well rapidly. | 2013-07-04 |
20130171603 | Method and System for Presenting Interactive, Three-Dimensional Learning Tools - A system includes an education module ( | 2013-07-04 |
20130171604 | ASSESSMENT TOOL AND GRADED ACTIVITY FOR FINE-GROSS MOTOR SKILLS, VISUAL AND COGNITIVE PROCESSING - A timed assessment and graded activity, allows professional staff, occupational therapist, school psychologist, physician (neurologist and pediatrician), and the like, to assess their patients in various areas. The assessment and graded activity can be used for motor skills, including fine-gross motor coordination and hand speed. The assessment and graded activity can also be used for assessing vision, including color, eye-hand coordination, crossing midline, left or right side neglect, and eye movements, crossing midline and left-right side neglect. Furthermore, the assessment and graded activity can be used for determining cognitive skills, including processing, concentration, attention deficit, problem solving, and ability to follow instructions. The 21-piece challenge as an assessment and graded activity designed to use a set of wooden dowels with its respective board. The 21 pieces of wood dowels contains five pieces of a first color, four pieces of three other colors, and two pieces of two other colors. | 2013-07-04 |
20130171605 | METHOD AND SYSTEM FOR DETERMINING ANSWERER - A method and system for determining an answerer is disclosed. The method includes: receiving a question from an asker; obtaining history answering statistics information of each online answerer, where an online answerer is a user with a label which represents that the user is available to answer a question; and determining from all online answerers at least one answerer for the question according to the history answering statistics information of each online answerer. With the method and system, an answerer which is available and suitable to answer a question can be determined for the question, and thus the question can be more likely to be answered quickly and correctly. | 2013-07-04 |
20130171606 | SMART GRID EDUCATIONAL TOOL AND SYSTEM FOR USING THE SAME - A smart grid educational tool and system for using the same is provided. The smart grid relates generally to electro-mechanical systems with mechanical structures that produce electrical signals and switching systems similar to an actual smart power grid. This electrical system relates specifically to structures that easily and quickly demonstrate to students and utility workers the architecture and power sources used by the electric companies in the generation and distribution of electricity. The device utilizes an infrared beam of light sent through a spinning fan or other device, which breaks up the beam, to a receiving unit which produces an AC wave which is later converted to a single frequency sine wave and analyzed on a computer monitor. | 2013-07-04 |
20130171607 | Self-revealing Gesture - Various embodiments provide self-revealing gestures that are designed to provide an indication of how to perform one or more different gestures. In at least one embodiment, an initiation gesture is received, relative to an object. The initiation gesture is configured to cause presentation of a visualization designed to provide an indication of how to perform a different gesture. Responsive to receiving the initiation gesture, the visualization is presented without causing performance of an operation associated with the different gesture. | 2013-07-04 |
20130171608 | Learning toy with sounds - A toy with forest like ambiance created by reflective surfaces of a toy tray box panels and with wild animals arranged in an interactive manner with sounds include spellings of such animal, skillfully decorated by reflecting surfaces that enhances the forest like ambiance and wherein the reflecting surfaces are part of a game box tray which has a base and two or more vertical side panels that form a play area and the box tray with base and side panels has two or more reflecting surfaces that can be utilized fully or covered partially. Such coverings of the reflective surfaces can enhance the ambiance of the play area and such reflecting surfaces create a near infinite tunnel of objects placed in the near vicinity of such reflecting surfaces. | 2013-07-04 |
20130171609 | Connecting Users in an Education Platform - An education digital reading platform suggests connections between users, wherein the users are represented as nodes in a social graph. The nodes may be identified from education materials and course registrations associated with a course and a user. The education digital reading platform also determines suggested connections between the nodes based on the education materials and the course registrations, wherein the suggested connections are based on a commonality between the nodes, such as being registered to a similar course, having the same major, etc. The determined suggested connections are provided to the users. If the users accept the suggested connections, communication and other services are enabled between the users. Such a method of connecting users may iterate when new users or information is added to the platform, such as when a student registers for a new course or a new syllabus is received. | 2013-07-04 |
20130171610 | MULTI-COMPONENT BOOK FOR AMELIORATIVE BEHAVIORAL MODIFICATION - A flip-book for educating a user is disclosed. It comprises a first book component and a second book component. A first cover comprises an initial portion of the first book component. A second book cover forms an initial portion of the second component of the book. The cover is positioned on the opposite side of the flip-book. The first component and the second component share a book spine. At least one page of ancient religious text is associated with the first book component. At least one page of modern day text is associated with the second book component. | 2013-07-04 |
20130171611 | APPARATUS FOR SIMULATING OPERATION OF FAN BLADES IN A GAS TURBINE - This disclosure describes a training apparatus, wherein embodiments of the training apparatus simulate operation of fan blades in a turbine engine. An advantage that practice of some disclosed embodiments of the training apparatus is to provide a platform to train skills for maintaining and servicing turbine engines without placing the individual and/or customer hardware in jeopardy. | 2013-07-04 |
20130171612 | Data Diagnostic Evaluation Device - A teaching aid to aid in evaluating data may include a frame member and an eye guide movably connected to the frame member to guide the user of the teaching aid in evaluating the data. The frame member may include a top frame wall, a pair of opposing a side frame walls to connect to the top frame wall and a bottom frame wall to connect to the pair of opposing side frame walls, and the frame member may include a divider wall to define a cavity for the data to be evaluated. | 2013-07-04 |
20130171613 | Flush preservation solution - Flush preservation solution for the preservation of cells in the absence of a blood supply comprising:
| 2013-07-04 |
20130171614 | EXTRACORPOREAL PERFUSION CIRCUIT SENSOR ASSEMBLY AND METHODS OF ISOLATING SENSORS THEREOF IN SEPARATE DRY AND WET ENVIRONMENTS AND STERILIZATION OF THE ASSEMBLY - Packaged cardiopulmonary bypass or organ perfusion system sensor subassemblies are provided. The packaged sensor subassemblies include a sensor subassembly and a package. The sensor subassembly includes a pre-calibrated pH sensor in a dry environment, a pre-calibrated PC0 | 2013-07-04 |
20130171615 | SELECTIVE LYSIS OF CELLS - Methods and devices for the selective lysis of cells in a sample comprising micro-organisms such as bacteria are provided. The selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions. | 2013-07-04 |
20130171616 | PIVOTING PRESSURIZED SINGLE-USE BIOREACTOR - Pressurized hermetically sealed bags disposed inside a cylindrical support and containing a septum with variable density of porosity and dividing the bag into two chambers are used to provide optimal mixing and gasification of nutrient media to grow a variety of biological cultures, particularly the cell cultures to produce a multitude of pharmaceutical and biotechnology products in a disposable system. | 2013-07-04 |
20130171617 | DEVICE AND METHOD FOR THE AUTOMATED ISOLATION AND TRANSFER OF AT LEAST ONE MICROSCOPIC SAMPLE FROM A SAMPLE CARRIER TO A COLLECTING SYSTEM - A device for the automated isolation and transfer of at least one microscopic sample from a sample carrier to a collecting system for subsequent automatic analysis is provided. The device comprises a selection unit for selecting at least one sample located on the sample carrier, a controllable isolation unit for the automated isolation of the at least one selected sample, a controllable transfer unit, which has carrier means for the defined receiving and deposition of the at least one selected isolated sample, for an automated and defined transfer of the at least one selected isolated sample from the sample carrier to the collecting system, and a control unit, which has a data link to the selection unit, the isolation unit and the transfer unit, for an automated isolation and transfer operation. | 2013-07-04 |
20130171618 | POROUS MEMBRANES HAVING A POLYMERIC COATING AND METHODS FOR THEIR PREPARATION AND USE - A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. The polymer coatings grafted to the porous membranes generally comprise a polymer of variable length of an electron beam (e-beam) reactive moiety, designated “poly-(A) | 2013-07-04 |
20130171619 | POROUS MEMBRANES HAVING A HYDROPHILIC COATING AND METHODS FOR THEIR PREPARATION AND USE - A modified porous membrane comprising a polymeric hydrophilic coating grafted to a porous membrane is described. The polymeric hydrophilic coatings grafted to the porous membranes comprise, for example, a PEG moiety such as a PEGMA, a PEGDA, or a TMPET, wherein the polymeric hydrophilic coating on the porous membrane decreases non-specific binding of unwanted material to the porous membrane and increases the signal to noise ratio in immunoassays, in vitro diagnostic tests, and point of care tests. Methods of making these modified porous membranes are also disclosed. | 2013-07-04 |
20130171620 | VIRAL VARIANTS AND METHODS FOR DETECTING SAME - The present invention relates generally to viral variants exhibiting reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic agents. | 2013-07-04 |
20130171621 | METHODS OF IN SITU DETECTION OF NUCLEIC ACIDS - Methods of detecting the presence or absence of a class of nucleic acid targets in single cells through direct or indirect capture of labels to the nucleic acids are provided, where such labels to the class of nucleic acid targets are indistinguishable from each other. Also described are methods of detecting individual cells, particularly a cell of a specific type from large heterogeneous cell populations, through detection of one or more of nucleic acid targets, where the labels to the one or more of nucleic acid targets are indistinguishable from each other. Related kits are also described. | 2013-07-04 |
20130171622 | COMPOSITIONS AND METHODS FOR DETECTING VIRAL INFECTION USING DIRECT-LABEL FLUORESCENCE IN SITU HYBRIDIZATION - The present invention relates generally to assays for the detection of viral infection and/or prognosis of viral infection and associated disease states. In particular, the invention relates to directly labeled viral-related nucleic acids having significant diagnostic, prognostic, and screening utilities and methods of using the same. | 2013-07-04 |
20130171623 | Binding Assays Utilizing Time-Resolved Up-Converting Luminescence Detection - This invention describes a general binding assay method to detect the presence and quantity of analyte in a sample. The method uses time-resolved up-converting fluorescence detection technique to provide highly sensitive detection without using expensive optical components such as band-pass optical filters. The method uses pulsed long wavelength light for excitation and time-delayed luminescence detection, resulting in little interferences from sample matrices. Furthermore, the usage of long wavelength excitation light requires simpler sample preparation and processing such as removal of red blood cells, which otherwise will significantly interfere with excitation efficiency of the luminescence probes. | 2013-07-04 |
20130171624 | Magnetic Binding Assays Utilizing Time-Resolved Up-Converting Luminescence Detection - This invention describes a general magnetic binding assay method to detect the presence and quantity of analyte in a sample. The method uses magnetic particles for separating and concentrating analytes of interest from complex samples and use time-resolved up-converting fluorescence detection technique to provide highly sensitive detection without using expensive optical components such as band-pass filters. The method uses pulsed long wavelength light for excitation and time-delayed luminescence detection, resulting in little interferences from sample matrices. Furthermore, the usage of long wavelength excitation light requires simpler sample preparation and clean-up such as removal of red blood cells, which otherwise will significantly interfere with excitation efficiency of the fluorescence probes. | 2013-07-04 |
20130171625 | BIOCHIPS AND RELATED AUTOMATED ANALYZERS AND METHODS - The present invention provides biochips that include: (a) a plurality of cards, each card having a plurality of card apertures extending therethrough, each respective card aperture having one or more cross sectional areas; and (b) a plurality of gaskets, at least one gasket residing intermediate two neighboring cards, each gasket having a plurality of gasket apertures extending therethrough. At least some of the gasket apertures have an area that is greater than that of at least one adjacent card aperture. Different sets of the gasket apertures and card apertures define a plurality of fluidic flow channels. Also provided herein are methods of making and using biochips. | 2013-07-04 |
20130171626 | METHODS OF EVALUATING GENE EXPRESSION LEVELS - Described herein are methods of evaluating the expression levels of DNA parts encoding proteins in test circuits. In particular, the methods disclosed herein are useful to evaluate the expression of an output protein regulated by a regulatory protein-genetic element pair. | 2013-07-04 |
20130171627 | Method for Producing Dendritic Cells - Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic stem cells in the presence of a cytokine or combination of cytokines which brings about differentiation of the embryonic stem cells into dendritic cells; and recovering the dendritic cells from the culture. In a further embodiment, the cells may be genetically modified. | 2013-07-04 |
20130171628 | METHOD AND DEVICE FOR ISOLATING CELLS FROM HETEROGENEOUS SOLUTION USING MICROFLUIDIC TRAPPING VORTICES - A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at least one expansion region disposed along the length thereof. The at least one expansion region is an abrupt increase in a cross-sectional dimension of the at least one microfluidic channel configured to generate a vortex within the at least one expansion region in response to fluid flow. A solution containing a population of cells at least some of which have diameters ≧10 μm flows into the inlet. A portion of cells is trapped within vortex created within the at least one expansion region. The trapped cells may then released from the expansion region. | 2013-07-04 |
20130171629 | Extraction Device and Method for Extracting Ingredients from a Biological Sample - An extraction device ( | 2013-07-04 |
20130171630 | METHODS OF USING TELOMERES AS MARKERS FOR AGING - The invention relates to a simple, reproducible, fast, and accurate method of quantifying and measuring telomeres in a clinical sample. The invention further relates to kits comprising premixed and optimized buffers, DNA polymerase, primers, and instructions for the detection of telomere length and quantities. Also envisioned are complete kits further including instrumentalities for the detection of telomere length and quantities. | 2013-07-04 |
20130171631 | CONJUGATES OF NUCLEOTIDES AND METHOD FOR THE APPLICATION THEREOF - The invention relates to a novel method for enzymatically marking nucleic acid chains (target sequences) by using nucleotide conjugates. Said nucleotide conjugates are capable of binding specifically to the target sequence under reaction conditions and of being incorporated in the complementary growing strand by means of a polymerase. The nucleic acid chains marked with such conjugates can be bound to the solid phase. The marking can be carried out in parallel with the enzymatic amplification of target sequences. | 2013-07-04 |
20130171632 | METHODS AND COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDES USING LIGHT HARVESTING MULTICHROMOPHORES - Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided. | 2013-07-04 |
20130171633 | THERMAL REACTION DEVICE AND METHOD FOR USING THE SAME - An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block. | 2013-07-04 |
20130171634 | BIOMARKERS FOR CANCERS RESPONSIVE TO MODULATORS OF HEC1 ACTIVITY - Contemplated compositions and methods are drawn to biomarkers and methods related to treatment of neoplastic disease with Hec1 inhibitor. Gene status and/or expression levels of Hec1(HEC), Rb(RB1), and/or p53 (TP53) may be useful as biomarkers for sensitivity to treatment with a Hec1 inhibitor. In addition, Hec 1 inhibitors may show synergistic effects when used in conjunction with cytotoxic drugs. | 2013-07-04 |
20130171635 | DUAL OLIGONUCLEOTIDE METHOD OF NUCLEIC ACID DETECTION - Methods for amplifying and detecting nucleic acids are described, as well as sets of 5′ labeled oligonucleotides. | 2013-07-04 |
20130171636 | METHOD OF DNA SEQUENCING BY POLYMERISATION - Described herein is a method for determining a nucleic acid sequence, said method comprising: a) denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence; b) hybridizing a single-stranded nucleic acid molecule, the primer, with the said denatured double-stranded nucleic acid molecule; c) applying a tension to the hybridized primer/double-stranded nucleic acid molecule obtained in b); d) incubating the hybridized primer/double-stranded nucleic acid molecule obtained in b) with a polymerase in conditions which will lead to at least one pause in replication; and e) determining a position of the said pause in replication with respect to one end of the double-stranded nucleic acid. | 2013-07-04 |
20130171637 | MATERIALS AND METHODS FOR DIAGNOSIS OF BLADDER CANCER AND MONITORING RECURRENCE THEREOF - A method of diagnosing bladder cancer in a patient comprising contacting a sample of urothelial cells obtained from the patient with a set of detectably labeled probes comprising locus-specific probes for c-myc and AURKA and centromeric probes for chromosomes 7 and 17 under hybridization conditions, and determining the presence of chromosomal abnormalities, wherein the presence of chromosomal abnormalities involving at least two of the detectably labeled probes indicates that the patient has bladder cancer; a method of monitoring recurrence of bladder cancer in a patient; a set of probes comprising locus-specific probes for c-myc and AURKA and centromeric probes for chromosomes 7 and 17; and a kit comprising (a) the set of probes and (b) instructions for diagnosing bladder cancer, or monitoring the recurrence thereof, in a patient. | 2013-07-04 |
20130171638 | MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PROSTATE CANCER - A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient. | 2013-07-04 |
20130171639 | MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS, MONITORING OF RECURRENCE, AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PANCREATOBILIARY CANCER - A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of pancreatobiliary cells from a patient with a set of detectably labeled probes comprising a locus-specific probe for MCL1 (myeloid cell leukemia sequence 1), a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for MYC, and a locus-specific probe for P16 under hybridization conditions and determining the presence of chromosomal abnormalities; a set of probes comprising a locus-specific probe for MCL1, a locus-specific probe for EGFR, a locus-specific probe for MYC, and a locus-specific probe for P16; and a kit comprising the set of probes and instructions for detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract, or inferring an increased risk thereof, in a patient. | 2013-07-04 |
20130171640 | SOLID REAGENT DISSOLVING DEVICE AND METHOD OF DISSOLVING SOLID REAGENT BY USING THE SAME - A solid reagent dissolving device including a flexible layer; an upper plate disposed on the flexible layer; and a lower plate disposed under the flexible layer, wherein the upper plate comprises a plurality of minute channels, a dissolution chamber connected with the plurality of minute channels, and a protrusion for limiting a flow of a fluid flowing through one of the plurality of minute channels, the lower plate comprises a plurality of penetration holes that correspond to the protrusion and the dissolution chamber, respectively, and one side of each of the plurality of penetration holes, the plurality of minute channels, and the dissolution chamber are covered with the flexible layer, and method of using same. | 2013-07-04 |
20130171641 | METHOD AND COMPOSITIONS FOR DETECTING EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT FORMS IN CANCER CELLS - Method and compositions for screening for the presence of Epidermal Growth Factor Receptor variant 3 (EGFR(v3)) in a sample are described. The method comprises obtaining a sample containing a plurality of cells; hybridizing a set of chromosomal probes to the sample, wherein the set comprises an EGFR(v3)-probe and a probe to chromosome 7 different from an EGFR(v3)-probe; and visualizing the hybridization pattern of the set of chromosomal probes in the plurality of cells of the sample, wherein the presence of at least one copy of chromosome 7 lacking a hybridization signal of the EGFR(v3)-probe in at least one cell is indicative of the presence of the EGFR(v3) in the sample. The method and compositions are suitable for diagnosing the therapeutic outcome for treating a patient having a cancer with an anti-EGFR therapeutic agent and for screening a sample for a predisposition for forming an EGFR-associated cancer. | 2013-07-04 |
20130171642 | AUTOMATED ANALYSIS OF CIRCULATING TUMOR CELLS - The disclosure provides methods for automated characterization of circulating tumor cells (CTCs), for example using automated tissue strainers. In specific examples, such methods permit characterizing a prostate cancer sample by simultaneously or contemporaneously detecting ERG rearrangements and PTEN deletions in the same CTC. Also provided are kits that can be used with such methods. | 2013-07-04 |
20130171643 | Sequence Specific Real-Time Monitoring of Loop-Mediated Isothermal Amplification (LAMP) - Gene-based diagnostics capable of rapidly discriminating selected strains of a selected pathogen from other populations within the same species are disclosed. Sequence-specific, real-time monitoring of LAMP of DNA may be accomplished through the use of oglionucleotide probes, referred to as “assimilating probes.” The assimilating probes include two oglionucleotide strands, one which includes a quencher (referred to as the quenching probe) and another which includes a fluorophore (referred to as the fluorescent probe). A fluorescent signal results when the two strands are displaced from one another during the LAMP reaction. By monitoring the emitted fluorescence, sequence specific amplification may be detected. | 2013-07-04 |
20130171644 | COINCIDENCE DETECTION - The invention relates to a method of detecting the coincidence of two biomolecular structures in a solid phase sample, said method comprising: (i) providing a first and a second fusion protein, each fusion protein comprising (a) a detection domain, said detection domain comprising a DNA binding domain; said detection domain capable of binding a cognate specific nucleotide sequence in co-operation with a further detection domain; (b) a recognition domain, said recognition domain capable of binding a target biomolecular structure; and (c) a connector domain; said connector domain being fused at one end to the detection domain and being fused at the other end to the recognition domain; wherein at least two of (a), (b) and (c) are heterologous to one another; wherein the recognition domains of said first and said second fusion proteins are capable of binding to first and second biomolecular structures; (ii) contacting the sample with said first and second fusion proteins; (iii) incubating to allow binding; (iv) removing unbound fusion protein; (v) contacting the sample with nucleic acid comprising said cognate specific nucleotide sequence; (vi) incubating to allow heterotrimeric binding of the nucleic acid; (vii) detecting nucleic acid bound to the sample wherein detection of nucleic acid in step; (vii) indicates that the two biomolecular structures are present coincidentally in said sample. | 2013-07-04 |
20130171645 | GENETIC MAKE-UP MODIFIES CANCER OUTCOME - A frequent SNP A259G (K87E) genotype switch in the MMP8 gene in has been found to modify the clinical behavior of cancers. The modification varies based on the patient's genotype for the SNP, and whether homozygous or heterozygous. One particular genotype for this SNP leads to more aggressive tumor behavior and worst clinical outcome than the others. | 2013-07-04 |
20130171646 | NANOP ARTICLE-OLIGONUCLEOTIDE HYBRID STRUCTURES AND METHODS OF USE THEREOF - The invention relates to hybrid structures comprising an amphiphilic nucleic acid-block co-polymer assembly on the exterior and a nanoparticle core, and methods of use thereof. | 2013-07-04 |
20130171647 | PREDICTING RESPONSES TO ANDROGEN DEPRIVATION THERAPY - This document provides methods and materials for identifying prostate cancer patients likely to respond to an androgen deprivation therapy. For example, methods and materials for identifying a prostate cancer patient likely to respond to an androgen deprivation therapy based at least in part on the presence of a genetic variation in a TMRT11 nucleic acid are provided. This document also provides methods and materials for identifying prostate cancer patients likely to survive prostate cancer related death for a short or long period of time. For example, methods and materials for identifying a prostate cancer patient likely to survive prostate cancer related death for a short or long period of time based at least in part on the presence of a genetic variation in a UGT1A3 nucleic acid, a UGT1A7 nucleic acid, and/or a UGT1A10 nucleic acid are provided. | 2013-07-04 |
20130171648 | METHOD FOR SEQUENCING A POLYNUCLEOTIDE TEMPLATE - The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which permit the sequential determination of nucleotide sequences in two distinct and separate regions on complementary strands of the double-stranded polynucleotide template. The two regions for sequence determination may or may not be complementary to each other. | 2013-07-04 |
20130171649 | METHODS AND MEANS FOR PREDICTING OR DIAGNOSING DIABETES OR CARDIOVASCULAR DISORDERS BASED ON MICRO RNA - The present invention relates to a method of detecting diabetes and associated complications. The present invention also relates to a method of predicting diabetes. The present invention also relates to a method of detecting and/or predicting vascular disorders and cardiovascular disorders. The present invention also relates to kits for performing the methods of the present invention. | 2013-07-04 |
20130171650 | IDENTIFICATION OF FETAL DNA AND FETAL CELL MARKERS IN MATERNAL PLASMA OR SERUM - The present invention relates to the identification of fetal specific nucleic acids and fetal cell markers in maternal plasma or serum. In particular, the present invention relates to methods which rely on the analysis of polymorphic alleles of a population to determine an allele which is possessed by the fetus but absent from the mother. Fetal specific alleles identified using the methods of the invention can be used to quantify fetal DNA from maternal plasma or serum. In addition, antigens encoded by alleles identified using the methods of the invention can be targeted in methods of isolating or detecting fetal cells. | 2013-07-04 |
20130171651 | METHODS FOR MEASURING DEGREE OF CURE OR SOLDIFICATION OF A COMPOSITION - The present invention is directed to methods of measuring the degree of cure or solidification of a composition. Desirably, such methods are quantitative and ascertain the degree of cure or solidification in a non-destructive manner such that they are adaptable for on-line, real-time monitoring. | 2013-07-04 |
20130171652 | Blocking Reagent and Methods for the Use Thereof - The present invention relates to the use of a conjugate of a non-analyte-specific binding protein coupled to a nucleic acid as a blocking reagent in a probe-based detection assay, which uses a probe comprising a proteinaceous analyte-binding partner coupled to a nucleic acid domain to detect an analyte in a sample. | 2013-07-04 |
20130171653 | METHODS AND KITS FOR THE DIAGNOSIS OF PROSTATE CANCER - The present invention relates to the use of PSGR, a member of the G-protein-coupled olfactory receptor family which is over-expressed in prostate cancer tissue, as a marker suitable for an urine-based diagnostic test for prostate cancer which require only typical prostate manipulation and sample acquisition scenarios avoiding invasive tissue collection. | 2013-07-04 |
20130171654 | DNA INTERCALATOR DETECTION - A DNA intercalator detection system can include a filtration unit a control sample conditioner operably coupled with the filtration unit and an analytic unit operably coupled with the filtration unit and control sample conditioner and having an electronic chemical array (ECA) reaction component. A data processing unit is operably coupled with the analytic unit and configured to compare and determine a difference between electronic data of a test sample and a conditioned control sample from the ECA reaction component. The difference provides an indication of whether or not a DNA intercalator is present in the test sample. | 2013-07-04 |
20130171655 | NOVEL BIOLOGICAL DETECTION METHOD FOR DIOXINS IN SERUM, AND A DIAGNOSTIC USE THEREFOR IN METABOLIC SYNDROME AND RELATED CONDITIONS - The present invention relates to a novel biological detection method for dioxins in serum and a diagnostic use thereof in metabolic syndrome and related conditions. More particularly, according to the present invention, a significant correlation between dioxin content in serum and physical variables has been confirmed by measuring luciferase activity through the use of serum as a whole and cells transformed with a recombinant vector comprising a gene construct in which a dioxin responsive element, a promoter and a reporter gene are operably linked. And there is an improvement in this method of the present invention over the conventional methods which require a preprocessing step in order to purify dioxins from serum, by which plural samples can be analyzed easily and accurately even with a very small amount of each because of the use of serum as a whole. Therefore, the detection system of the present invention which involves total serum processing in a genetically transformed cell line comprising a recombinant reporter gene whose expression is modified by dioxin compounds can be effectively used for the biological detection of dioxins in serum. This method can also be used to research the correlation between specific POPs and patient's disease factors by accurate detection of POPs such as dioxins in the serum, and further this method can be effectively used to predict the occurrence of disease and to determine treatability. | 2013-07-04 |
20130171656 | DETECTION, IDENTIFICATION AND DIFFERENTIATION OF PROTEUS SPECIES USING THE SPACER REGION - The present invention relates to new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of | 2013-07-04 |
20130171657 | RAPID SCREENING OF BIOLOGICALLY ACTIVE NUCLEASES AND ISOLATION OF NUCLEASE-MODIFIED CELLS - Disclosed herein are methods and compositions for rapidly identifying active nucleases and cells having nuclease-mediated genomic modifications. | 2013-07-04 |
20130171658 | ISOLATION AND DEGLYCOSYLATION OF GLYCOPROTEINS - The invention provides more rapid and cost-effective methods of deglycosylating target glycoproteins. In methods of the invention, the target glycoprotein is isolated from initial samples, which may contain multiple other glycoproteins, by subjecting the initial sample to a solid phase containing an affinity ligand, such as a deglycosylated antibody, that interacts specifically with the target glycoprotein. Once separated from the sample, the target glycoprotein can be deglycosylated in situ, or eluted from the solid phase, quantitated, and then deglycosylated. | 2013-07-04 |
20130171659 | METHODS OF PROGNOSIS AND DIAGNOSIS OF RHEUMATOID ARTHRITIS - Provided are methods of diagnosing rheumatoid arthritis in a patient by detecting the presence and/or amount of a biomarker of rheumatoid arthritis in a sample from the patient. The methods and biomarkers may be used to develop an accurate prognosis for a patient having rheumatoid arthritis or suspected of having rheumatoid arthritis, or to accurately diagnose a patient having, or suspected of having rheumatoid arthritis. The methods and biomarkers may be used to identify and/or classify a patient as a candidate for a rheumatoid arthritis therapy. | 2013-07-04 |
20130171660 | BLOOD MARKER FOR RENAL CANCER - The present invention provides a blood marker for renal cancer, more specifically, a blood marker that can be practically used for clinical diagnosis of renal cancer. The present invention also provides a blood marker that can be practically used for follow-up after treatment such as surgery and during treatment such as medication for renal cancer. A blood marker for renal cancer selected from the group consisting of Galectin-1, Galectin-3, and α-enolase. Galectin-1 and/or Galectin-3 as a blood marker for renal cancer for use in an examination performed before diagnostic imaging. α-Enolase as a blood marker for renal cancer for use in monitoring during and/or after treatment for renal cancer. | 2013-07-04 |
20130171661 | Assay for Identification of LRRK2 Inhibitors - A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the phosphorylation state of Ser910 and/or Ser935 of the LRRK2; and/or b) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the binding of the LRRK2 to a 14-3-3 polypeptide. The method may comprise or further comprise the step of assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the subcellular location of LRRK2. The method is considered to be useful in assessing the effect of putative LRRK2 inhibitors in cell based systems, including in vivo systems. | 2013-07-04 |
20130171662 | ASSAY - This disclosure relates to a diagnostic/prognostic assay for prostate cancer and including kits used in said assay. | 2013-07-04 |
20130171663 | METHOD AND KIT FOR MEASUREMENT OF ENDOTOXIN LEVEL USING BIOLUMINESCENT ASSAY - The present invention provides a method comprising allowing a reaction of a sample, a reagent containing Factor C, which can be activated by binding with endotoxin, and a synthetic luminescent substrate comprising a luminescent substrate bound to a peptide, for release of the luminescent substrate from the synthetic luminescent substrate, allowing a luminescent enzyme to act on the luminescent substrate released in the luminescent substrate release step, for measurement of the luminescence intensity, and quantifying the level of endotoxin in the sample based on a measured value obtained in the luminescence measuring step, the method enabling endotoxin to be simply and quickly measured at a level that cannot be detected in conventional methods for endotoxin measurement, without use of any dedicated measuring device. | 2013-07-04 |
20130171664 | PH-RESPONSIVE FLUORESCENT FALSE NEUROTRANSMITTERS AND THEIR USE - This invention relates to compounds having the following structure: | 2013-07-04 |
20130171665 | METHODS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISORDERS AND ALZHEIMER'S DISEASE AND IMPROVING NORMAL MEMORY - The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease. | 2013-07-04 |
20130171666 | Purinergic (P2X) Receptors in Extra-Cellular Body Fluid - The invention relates to purinergic (P2X) receptors, to detection of protein in extra-cellular body fluids and to anti-bodies for the diagnosis or condition, especially cancer. | 2013-07-04 |
20130171667 | PHOTONIC CRYSTAL FIBER SENSOR - A method for sensing, a photonic crystal fiber, a method for fabricating a photonic crystal fiber sensor, and a Surface Enhanced Raman Scattering (SERS) sensing apparatus. The method for sensing comprises the steps of providing a photonic crystal fiber comprising a hollow core and a plurality of cladding holes around the hollow core; providing Surface Enhanced Raman Scattering (SERS) active nanoparticles; and adapting the SERS active nanoparticles and/or the fiber for SERS sensing. | 2013-07-04 |
20130171668 | DISULPHIDE BOND-STABILIZED FUNCTIONAL SOLUBLE MHC CLASS II HETERODIMERS - The present invention relates to disulphide bond stabilized recombinant MHC class II molecules. In particular, the present invention provides a recombinant MHC class II molecule, which comprises: (i) all or part of the extracellular portion of an MHC class II α chain; (ii) all or part of the extracellular portion of an MHC class II β chain; wherein (i) and (ii) provide a functional peptide binding domain and wherein (i) and (ii) are linked by a disulphide bond between cysteine residues located in the α2 domain of said α chain and the β2 domain of said β chain, wherein said cysteine residues are not present in native MHC class II α2 and β2 domains. Methods of producing these molecules in prokaryotic systems and various uses of these molecules form further aspects. | 2013-07-04 |
20130171669 | POROUS MEMBRANES HAVING A HYDROPHILIC COATING AND METHODS FOR THEIR PREPARATION AND USE - A modified porous membrane comprising a polymeric hydrophilic coating bonded to a porous membrane is described. The polymeric hydrophilic coatings grafted to the porous membranes comprise, for example, a PEG moiety such as a PEGMA, a PEGDA, or a TMPET, wherein the polymeric hydrophilic coating on the porous membrane decreases non-specific binding of unwanted material to the porous membrane and increases the signal to noise ratio in immunoassays, in vitro diagnostic tests, and point of care tests. Methods of making these modified porous membranes are also disclosed. | 2013-07-04 |
20130171670 | DIAGNOSIS AND MONITORING OF INFLAMMATION, ISCHEMIA AND APPENDICITIS - The invention provides methods and kits for diagnosing and monitoring inflammation and/or ischemia in an animal. The methods comprise determining the quantity of a post-translationally modified protein, other than phosphorylated tau, present in a body fluid from an animal. | 2013-07-04 |
20130171671 | METHODS FOR MODELING PROTEIN STABILITY - The present invention relates to a method for determining the highest temperature that is suitable for performing accelerated protein stability studies, as well as to a method for modeling real-time protein stability from accelerated stability data generated at said temperature. | 2013-07-04 |
20130171672 | Methods for Detecting Oncofetal Fibronectin - Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided herein, the sample is treated with a reagent and/or contacted with a non-specific binder. Provided are methods for testing subjects to ascertain health and disease status and to assess the risk of developing a disease or condition. Methods for detecting the presence of oncofetal fibronectin indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided. Methods and products for detection of oncofetal fibronectin for selection of concepti are | 2013-07-04 |
20130171673 | PIPETTE TIP, PIPETTE SYSTEM AND METHOD FOR PERFORMING ANALYSIS WITH THE PIPETTE TIP AND SYSTEM - The present invention relates to a pipette tip ( | 2013-07-04 |
20130171674 | METHOD FOR QUANTIFYING THE AMOUNT OF CHOLESTEROL IN HIGH-DENSITY LIPOPROTEIN 3 - A method that enables quantification of cholesterol in high-density lipoprotein 3 (HDL3) in a test sample without requiring a laborious operation is disclosed. The method for quantifying cholesterol in HDL3 comprises: Step 1 wherein phospholipase and/or sphingomyelinase is/are allowed to act on a test sample to transfer cholesterol to the outside of the reaction system; and Step 2 wherein cholesterol remaining in the reaction system is quantified. The method enables specific quantification of HDL3 cholesterol in a test sample using an automatic analyzer without requirement of a laborious operation such as ultracentrifugation or pretreatment. Further, quantification of the HDL2 cholesterol level can also be carried out by subtracting the HDL3 cholesterol level from the total HDL cholesterol level obtained by a conventional method for quantifying the total HDL cholesterol in a test sample. | 2013-07-04 |
20130171675 | MEASURING DEVICE AND MEASURING METHOD - The device enables measurement of both of blood glucose level and hemoglobin A1c level, being small-sized and thus portable, allowing the measurement of a small amount of a specimen and, being usable in POC. The device comprises: a test-piece-mounting section ( | 2013-07-04 |
20130171676 | METHOD FOR MEASURING GLYCATED HEMOGLOBIN - It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising reacting the hemoglobin-containing sample with a proteolytic enzyme in the presence of a surfactant, and then reacting the obtained reaction product with fructosyl peptide oxidase, wherein at least one of the former reaction and the latter reaction is performed in the presence of an isothiazolinone derivative; and measuring the generated hydrogen peroxide. The present invention provides a method for accurately and highly sensitively measuring glycated hemoglobin in a hemoglobin-containing sample without being influenced by hemoglobin. | 2013-07-04 |
20130171677 | RECOMBINANT PHYCOBILIPROTEINS WITH ENHANCED FLUORESCENCE AND PHOTOCHEMICAL PROPERTIES - Novel fluorescent phycobiliprotein fusion proteins and methods of use are described. The novel phycobiliproteins can be produced in a cell comprising two or more heterodimeric lyases, an apoprotein and a bilin reductase, which components react to form the phycobiliprotein fusion protein. Also described are phycobiliprotein based transcription reporter cells and assays, which cells conditionally express a heterologous, fluorescent, phycobiliprotein domain even in anoxic conditions. | 2013-07-04 |
20130171678 | SYSTEM AND METHOD FOR ANALYZING RISK OR PRESENCE OF ORGAN FAILURE - The present invention relates to a testing system for analyzing a risk of developing organ failure or presence of organ failure, said system comprising a disposable testing device arranged to receive a biological sample, which testing system is further arranged with means for measuring within said sample the total amount of at least a first biological marker in the form of an intracellular enzyme, and comprising means for analyzing the measured value of said intracellular enzyme, and based on the results thereof being arranged to communicate the risk of developing organ failure or presence of organ failure to an operator of said testing system. The present invention also relates to a method for analyzing a risk of developing organ failure, or analyzing presence of organ failure. | 2013-07-04 |
20130171679 | Micro-Incubation Systems for Microfluidic Cell Culture and Methods - A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems. | 2013-07-04 |
20130171680 | CHIMERIC AVIAN-BASED SCREENING SYSTEM CONTAINING MAMMALIAN GRAFTS - The present invention relates to animal model systems comprising a chimera between an avian embryo and a mammalian organism. Specifically, chimeric model systems comprising normal, diseased or genetically transformed mammalian cells and tissues transplanted into avian embryos, and uses thereof for in vivo testing of drugs and therapeutic modalities are disclosed. | 2013-07-04 |
20130171681 | BLOOD CELL ANALYZER, BLOOD CELL ANALYZING METHOD, AND NON-TRANSITORY STORAGE MEDIUM - The present invention is a blood cell analyzer. When only measuring one or more measurement items included in one group, a first sample supplying operation is performed which includes aspirating a blood sample by a first amount. When measuring one or more measurement items included in the one group and another measurement item not included in the one group, a second sample supplying operation and a third sample supplying operation are performed. The second sample supplying operation includes aspirating the blood sample by the first amount for the measurement items included in the one group, and the third sample supplying operation includes aspirating the blood sample by a second amount for the another measurement item. | 2013-07-04 |
20130171682 | Cell Culture and Gradient Migration Assay Methods and Devices - A number of novel improved microfluidic configurations and systems and methods of manufacture and operation for a microfluidic invasion assay system. | 2013-07-04 |
20130171683 | FLOW CYTOMETER APPARATUS AND METHOD - A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles. | 2013-07-04 |
20130171684 | Aerosol deposition apparatus for highly controlled range of population densities on material surfaces - An aerosol deposition apparatus is described for reproducibly preparing standardized coupon surfaces, which mimic aerosol deposited materials in an uncontrolled environment. The dome shaped apparatus is placed over the surfaces and an aerosol is delivered to the apex of the dome. The aerosol deposited surfaces may be used as standards for evaluating decontamination methods. | 2013-07-04 |
20130171685 | METHOD AND APPARATUS FOR CHARACTERIZING BIOLOGICAL OBJECTS - In order to quantitatively characterize biological objects, for example individual cells, a stimulus is applied to a biological object in a contactless fashion. A measurement and a further measurement are performed on the biological object in order to ascertain a response of the biological object to the stimulus, wherein the measurement and the further measurement comprise detecting Raman scattering on and/or in the biological object and/or capturing data using digital holographic microinterferometry (DHMI). The biological object is characterized according to a result of the measurement and is sorted if needed. The stimulus can be applied by means of a laser beam that creates optical tweezers or an optical trap, by means of ultrasonic waves or an electric or magnetic radio frequency field. | 2013-07-04 |