26th week of 2016 patent applcation highlights part 39 |
Patent application number | Title | Published |
20160187257 | MICROFLUIDIC DEVICE AND METHOD OF DETECTING SAMPLE SUPPLIED TO THE SAME - A microfluidic device includes a chamber configured to accommodate a sample and air, and a detection device provided with a light emitter configured to emit light towards the chamber on a light transmission path and a light receiver configured to receive the light, and further configured to measure an optical density of the chamber to determine whether the sample is accommodated in the chamber based on the received light. A boundary between the sample and the air accommodated in the chamber is provided on the light transmission path. | 2016-06-30 |
20160187258 | SYSTEMS AND METHODS FOR OXYGEN SENSING - An oxygen sensing system comprises a substrate structured to communicate optical signals. An oxygen sensing layer is disposed on the substrate and comprises an oxygen sensing molecule in a matrix in a first unexcited state and formulated to: (a) be excited by a first optical signal to move to a second state; (b) be quenched in the second state by oxygen; and (c) emit a second optical signal corresponding to an amount of oxygen. A protective layer is disposed on the oxygen sensing layer. The protective layer includes at least one of i) an oleophobic layer configured to protect the oxygen sensing layer from hydrocarbons and organic solvents and ii) an anti-fouling layer configured to protect the oxygen sensing layer from biofouling. A controller is optically coupled to the substrate and structured to generate the first optical signal, receive the second optical signal and determine oxygen concentration from the second optical signal. | 2016-06-30 |
20160187259 | STIMULATED EMISSION-DEPLETION (STED) MICROSCOPY BASED ON TIME GATING OF EXCITATION BEAM AND SYNCHRONOUS DETECTION OF FLUORESCENCE EMISSION - Method of optical microscopy by scanning a sample containing an excitable species, the method comprising: | 2016-06-30 |
20160187260 | LIBS MEASUREMENT TUBE - (EN) The invention relates to a special LIBS measurement tube focusing unit, referred to simply as LIBS measurement tube, for vertically dipping into a material to be analyzed, which material is moved in a horizontal flow, characterized in that the measurement tube extends vertically and is internally hollow and open at least at the bottom end, such that a bottom edge is formed at the bottom end, the measurement tube has an inlet for coupling in a laser beam and an outlet for coupling out an emission spectrum at the upper end, the measurement tube is constructed in such a way that, in the measurement tube, the laser beam is focused at the material to be analyzed, specifically bulk material, in particular raw, intermediate, and end products from the processing of potash, magnesium, rock salt, or evaporated salt, but without additional scattering and deflection occurring, such that a plasma of the material to be analyzed is produced within the measurement tube by the laser radiation and the emission spectrum of the material to be analyzed reaches the outlet for outcoupling through the interior of the measurement tube, and scrapers ( | 2016-06-30 |
20160187261 | Methods for Enhanced Grading of Mint Quality Coins - Grade enhancement of mint grade and proof-like coins is disclosed based on a determination of an indication that the coin was a “first strike” coin. First strike is defined by the first 10% or less of coins struck by the same die and may be determined by the location of a physical attribute of the coin present in at most 10% of similar coins struck by the same die. First strike in proof-like coins may be determined by frosted white cameo. | 2016-06-30 |
20160187262 | INSPECTION DEVICE OF DISPLAY DEVICE AND INSPECTION METHOD OF DISPLAY DEVICE - An inspection device of a display device includes a first illumination unit providing a first incident light to the display device at a first incident angle, a second illumination unit providing a second incident light to the display device at a second incident angle, a third illumination unit providing a third incident light to the display device at a third incident angle, and a defect detector receiving at least one of a first reflection light obtained from the first incident light reflected by the display device at a first reflection angle, a second reflection light obtained from the second incident light reflected by the display device at a second reflection angle, and a third reflection light obtained from the third incident light reflected by the display device at a third reflection angle to detect defects of the display device. | 2016-06-30 |
20160187263 | Remote Analyte Testing System - A system includes an apparatus having a test medium with a machine-readable identifier, the medium enabled to accept an analyte for a test, a network-connected communication device having imaging capability, enabled to record contextual information, and executing coded instructions, a server having coupled to at least one data repository, and coded instructions executing on a processor. A user applies the analyte to the test medium, allows time to complete, and initiates an image capture, wherein a data structure, including at least a resulting image, images or video stream, including one or more images of the test result, one or more images of the machine-readable identifier, contextual information captured at the time of the test and identify of the test subject providing the analyte, is transmitted on the network to the network-connected server, where the data structure is recorded. | 2016-06-30 |
20160187264 | Bore Testing Device - A testing device for testing an inner surface of a rotationally symmetrical cavity in a workpiece has a measuring head which defines an axial direction, and on which an optical system is situated. The optical system is in image transmission connection with an image recorder and a downstream evaluation apparatus. The testing device also has an illumination arrangement for illuminating an imaging area of the inner surface which is detected by the optical system. The illumination arrangement is designed and configured for illuminating the inner surface which is detected by the optical system. The illumination arrangement can illuminate the inner surface to be tested from different illumination directions in order to generate shadow images of the topography of the inner surface. The evaluation apparatus is designed and configured for determining the topography based on the shadow images recorded by the image recorder. | 2016-06-30 |
20160187265 | Bore Testing Device - A bore testing device for testing the inner surface of a bore in a workpiece is described. The bore testing device has a measuring head which defines an axial direction, and on which axial direction an optical system is situated which is in image transmission connection with a digital image sensor and a downstream evaluation apparatus. An apparatus for determining surface depth information from the output signals of the digital image sensor is provided. | 2016-06-30 |
20160187266 | SYSTEM AND METHOD FOR MEASUREMENT OF MATERIAL PROPERTY USING VARIABLE REFLECTOR - A system and method for measuring a material includes at least one transmitter for transmitting a first signal and a second signal. A variable reflector reflects a portion of the first signal at a first reflecting property to produce a first reflected signal, the portion of the first signal having traveled through the material. The variable reflector also reflects a portion of the second signal at a second reflecting property to produce a second reflected signal, the portion of the second signal having traveled through the material. A receiver receives the first received signal and the second received signal, the first received signal includes the first reflected signal having traveled through the material and the second received signal includes the second reflected signal having traveled through the material. The first reflected signal and the second reflected signal providing an indication of at least one property of the material. The at least one property includes permittivity, attenuation, anisotropy, and frequency dependency of the material. | 2016-06-30 |
20160187267 | APPARATUS AND METHOD FOR ALIGNING TWO PLATES DURING TRANSMISSION SMALL ANGLE X-RAY SCATTERING MEASUREMENTS - The disclosure provides an apparatus for aligning first and second plates that are parallel to each other and have the same orientation. The apparatus includes a detector that detects composite small-angle X-ray scattering emitted from patterns of the first and second plates that are perpendicularly impinged by X-ray, and a moving unit that aligns the first and second plates according to a composite amplitude distribution of the composite small-angle X-ray scattering. Therefore, the first and second plates are aligned to each other accurately. | 2016-06-30 |
20160187268 | METHOD FOR EVALUATING CRYSTAL GRAIN SIZE DISTRIBUTION OF POLYCRYSTALLINE SILICON - The method comprises following steps; a collected disk sample ( | 2016-06-30 |
20160187269 | VOLUMETRIC-MOLECULAR-IMAGING SYSTEM AND METHOD THEREFOR - An imaging system operative for providing a volumetric molecular image of an object is disclosed. The imaging system interrogates the object with structured x-ray radiation while continuous relative motion between the object and source is induced during a measurement period. As the radiation passes through the object, the radiation scatters based on the molecular composition within the object, and the scattering changes as a function of time due to the relative motion between the source and object. Coherent scatter radiation is detected and processed to reconstruct an estimate of the three-dimensional molecular structure of the object using a reconstruction algorithm, such as maximum likelihood estimation. | 2016-06-30 |
20160187270 | System For Active Long Range Detection And Identification Of Special Nuclear Materials Using A High Intensity Particle Beam - A long-range method and a system for reliably detecting and identifying special nuclear materials is provided that relies on the emission of delayed neutrons present in the decay of fission products (delayed neutron precursors) as a unique signature for the special nuclear materials, such as highly enriched uranium ( | 2016-06-30 |
20160187271 | Method for Monitoring Performance of Process Catalysts - Disclosed is a method for determining when to replace a guard bed material used to remove one or more catalyst poisons from a feed based on a parameter change in a process A guard bed having a guard bed material is in fluid communication with a catalyst bed having a catalyst. At least three monitors are positioned in said guard bed or said catalyst bed and at least one parameter of the guard bed or catalyst bed is monitored. A feed component comprising one or more catalyst poisons is supplied to said guard bed or said catalyst bed. The feed is contacted with said guard bed material or said catalyst to remove at least a portion of a catalyst poison and to form a product which produces an increase or a decrease in said parameter. The monitored parameters are compared to determine when to replace the guard bed material. | 2016-06-30 |
20160187272 | ENCLOSURE SURFACE TEMPERATURE ESTIMATION METHOD AND ELECTRONIC APPARATUS - A processor disposed over a substrate of an electronic apparatus acquires a first measured value from a temperature sensor disposed on the substrate, and calculates surface temperature of a surface of an enclosure of the electronic apparatus on the basis of a transfer function G(s) based on a first thermal resistance and a first thermal capacitance between a heat source over the substrate and the surface of the enclosure, a transfer function H(s) based on a second thermal resistance and a second thermal capacitance between the heat source and the temperature sensor, and the first measured value. | 2016-06-30 |
20160187273 | PHOTOMETRIC ENTHALPY CHANGE DETECTION SYSTEM AND METHOD - A method for detecting an enthalpy change includes providing a first mixture and a second mixture to a drop generator. The first mixture includes a ligand. The second mixture contains a target molecule. The method further includes generating a drop in the drop generator. The drop includes the target molecule, a temperature-sensitive reporter compound, and the ligand. The method also includes measuring a property of the temperature-sensitive reporter compound in the drop to determine an amount of enthalpy change that has occurred. | 2016-06-30 |
20160187274 | DYNAMIC CHEMICAL SENSORS - Provided herein are embodiments relating to chemical sensors. The sensors include one or more molecules that can transition between the cis and trans configurations thereby altering the degree of hydrophobicity of the system and providing for a sensor whose sensitivity and/or selectivity in regard to hydrophobicity can be altered as desired. | 2016-06-30 |
20160187275 | Sensing System Using a Marginal Oscillator - A sensor system comprises a marginal oscillator. A tank circuit comprises inductive and capacitive elements including a probe arranged to generate an electromagnetic field in a sensing region. A non-linear drive circuit drives oscillation of the tank circuit by supplying a differential signal pair of complementary signals across the tank circuit, sustaining the oscillation on the basis of at least one of the complementary signals. A detection circuit detects a characteristic of the oscillation of the tank circuit that is dependent on the electromagnetic properties of the contents of the sensing region and to derive a signal representing the at least one characteristic. The differential signaling provides numerous advantages, including improved accuracy and signal-to-noise. | 2016-06-30 |
20160187276 | ELECTROCHEMICAL NANOSENSORS FOR BIOMOLECULE DETECTION - Sensor devices, methods and kits for detection of biomolecules are provided. According to various embodiments, the devices, methods and kits provide enhanced sensitivity through the measurement of electrochemical impedance and related properties. Certain embodiments employ nanostructured electrode elements including nanotubes, nanoparticles, nanowires, and nanocones. In a particular embodiment, single walled carbon nanotubes disposed in interconnected networks are used as electrodes. The device, methods and kits described herein have application for detection and measurement of biomolecular species including polynucleotides, proteins, polysaccharides and the like. | 2016-06-30 |
20160187277 | SENSING SYSTEM AND METHOD - A sensor system includes a multi-frequency sensor assembly including a single sensor body housing with a sensing region circuit and a sensor reader disposed in the sensor body. The sensor body is configured to be in operational contact with a fluid. The sensing region circuit is configured to generate different electric fields having different frequencies in the fluid. The sensor reader includes one or more processors configured to examine one or more impedance responses of the sensing region circuit at different frequencies and to determine one or more properties of the fluid based on the one or more impedance responses that are examined. | 2016-06-30 |
20160187278 | METHOD FOR LOCATING A WAFER IN THE INGOT OF SAME - A method for determining the original position of a wafer in an ingot made from semiconductor material comprises the following steps: measuring the interstitial oxygen concentration in an area of the wafer; measuring the concentration of thermal donors formed in said area of the wafer during a previous solidification of the ingot; determining the effective time of a thermal donor formation anneal undergone by the wafer when solidification of the ingot took place, from the thermal donor concentration and the interstitial oxygen concentration; and determining the original position of the wafer in the ingot from the effective time. | 2016-06-30 |
20160187279 | METAL OXIDE GAS SENSOR ARRAY DEVICES, SYSTEMS, AND ASSOCIATED METHODS - Sensor devices and systems for detecting an analyte are disclosed and described. In one embodiment, a transducer array operable to detect a plurality of analytes is provided. Such an array may include a support substrate and a plurality of Metal Oxide Semiconductor (MOS) sensors coupled to the substrate. Each MOS sensor can further include a MOS active material, a plurality of heating elements thermally coupled to the MOS active materials in a position and orientation that facilitates heating of the MOS active materials, and an electrode functionally coupled to the MOS active material and operable to detect a response signal generated by the MOS active material. | 2016-06-30 |
20160187280 | MATERIALS AND SENSORS FOR DETECTING GASEOUS AGENTS - A sensor for detecting gaseous agents has a transducer, which includes an electrical resonant circuit that forms an antenna. The sensor further includes a sensing material that is disposed on at least a portion of the transducer. The sensing material is configured to simultaneously exhibit a capacitance response and a resistance response in the presence of a gaseous agent. The sensor may be reversible, battery free, and may require no electrical contact with a sensor reader. | 2016-06-30 |
20160187281 | HYDROGEN ION ELECTRODE COMPOSED OF COMPOSITE MATERIAL OF NANO IRIDIUM OXIDE AND POLYMER RESIN AND ENABLING SURFACE REGENERATION, PH SENSOR USING SAME, AND METHOD FOR MANUFACTURING SAME - Provided are a hydrogen ion electrode composed of a composite material of polymer resin and nano iridium oxide, the composite material containing 1-10 nm sized nano iridium oxide particles and/or aggregates thereof which are dispersed to be electrically connected to each other in a moldable, thermoplastic, and hydrophobic polymer resin matrix; a pH sensor using the same; and a method for manufacturing the same. The surface of the hydrogen ion electrode shows very fast pH sensitivity when exposed to a sample solution, and the pH sensitivity is approximate to biphasic characteristics. Furthermore, regardless of high reproducibility of pH sensitivity, abrupt pH change, and repetitive use, very low hysteresis, durability due to high physical strength, and high surface regeneration due to polishing are exhibited, and thus, the lifetime of the electrode can be extended and various sizes and shapes of electrodes can be easily manufactured. | 2016-06-30 |
20160187282 | DEVICE FOR SINGLE MOLECULE DETECTION AND FABRICATION METHODS THEREOF - Disclosed herein is a device comprising an electrode pair comprising a first electrode and a second electrode; a nanogap channel; wherein a portion of the nanogap channel is sandwiched between the first electrode and the second electrode; wherein at least a portion of the first electrode directly faces at least a portion of the second electrode, across the nanogap channel; wherein the portion of the first electrode and the portion of the second electrode are exposed to an interior of the nanogap channel; and wherein the first electrode or the second electrode comprises doped diamond, silicon carbide or a combination thereof. Also disclosed herein is a method comprising forming on a carrier substrate a first material layer comprising doped diamond, silicon carbide or a combination thereof; bonding the first material layer onto an electrical circuit. | 2016-06-30 |
20160187283 | ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH A SOLUBLE ELECTROCHEMICALLY-ACTIVE COATING OPPOSITE A BARE ELECTRODE - Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode An electrochemical-based analytical test strip (EBATS) for the determination of an analyte in a bodily fluid sample includes an electrically insulating base layer, a patterned electrically conductive layer disposed on the electrically insulating base layer and including a plurality of electrodes, and an enzymatic reagent layer disposed on a portion of the patterned conductor layer and defining a bare electrode(s) and a plurality of enzymatic reagent covered electrodes from the plurality of electrodes. The EBATS also includes a patterned spacer layer, a top layer having an underside surface (USS), and a soluble electrochemically-active coating (SEAC) disposed on the USS of the top layer. In addition, at least the patterned spacer layer and top layer define a sample-receiving chamber within the EBATS. Furthermore, the SEAC is disposed on the USS of the top layer within at least a portion the sample-receiving chamber and in an opposing relationship to the bare electrodes. | 2016-06-30 |
20160187284 | MULTI-PORE SILICON SUBSTRATE AND BIOTECHNOLOGICAL TEST STRIP WITH THE MULTI-PORE SILICON SUBSTRATE - A multi-pore silicon substrate and a biotechnological test strip with the multi-pore silicon substrate. The multi-pore silicon substrate includes a main body. The main body has a first side, a second side and multiple pores. The pores pass through the main body, respectively. Two ends of each pore communicate with the first and second sides of the main body. The multi-pore silicon substrate is applied to a biotechnological test strip necessitating the multi-pore silicon substrate. The biotechnological test strip with the multi-pore silicon substrate improves the shortcomings of the conventional in vitro test strip that it is uneasy to manufacture the test strip and the blood filtering effect is poor. Also, the biotechnological test strip with the multi-pore silicon substrate is manufactured at much lower cost and the reservation period of the biotechnological test strip with the multi-pore silicon substrate is prolonged. | 2016-06-30 |
20160187285 | GAS SENSOR ELEMENT AND GAS SENSOR - A plate-like gas sensor element extending in a longitudinal direction includes a plate-like composite ceramic layer which has an insulation portion having a through hole formed at a longitudinally forward end side and a solid electrolyte portion disposed in the through hole; an electrode portion disposed in contact with the solid electrolyte portion on a one-main-surface side of the composite ceramic layer; and a lead portion which is in contact with only the insulation portion on the one-main-surface side of the composite ceramic layer, whose forward end is recessed from the through hole toward a rear end side with respect to the longitudinal direction, and which is electrically connected to the electrode portion and extends longitudinally rearward. A rear end portion of the electrode portion overlaps with a forward end portion of the lead portion on the insulation portion on the one-main-surface side of the composite ceramic layer. | 2016-06-30 |
20160187286 | APPARATUS AND ASSOCIATED METHODS FOR ANALYTE DETECTION - An apparatus comprising first and second electrodes ( | 2016-06-30 |
20160187287 | Determination Device for Determining Antirust Effect of Treated Water and Method for Determining the Same - A determination device capable of easily and quickly determining an enhancement in rust-prevention of treated water and a method for determining the same are provided. The device has first and second potential difference measurement devices, each including at least one anode electrode, a pair of cathode electrodes, a first current generator for applying an electric current between the anode and a first cathode of the pair, a second current generator for applying an electric current between the anode and a second cathode, an electric current changer for periodically changing a magnitude of a current between the first and second cathodes, a measurement/output equipment for measuring a potential difference across the first and second cathodes, and a determiner for determining antirust effect of treated water based on signal A outputted by the equipment of the first potential difference measurement device and signal B outputted by that of the second device. | 2016-06-30 |
20160187288 | NANOFLUID SENSOR WITH REAL-TIME SPATIAL SENSING - A semiconductor structure capable of real-time spatial sensing of nanoparticles within a nanofluid is provided. The structure includes an array of gate structures. An interlevel dielectric material surrounds the array of gate structures. A vertical inlet channel is located within a portion of the interlevel dielectric material and on one side of the array of gate structures. A vertical outlet channel is located within another portion of the interlevel dielectric material and on another side of the array of gate structures. A horizontal channel that functions as a back gate is in fluid communication with the vertical inlet and outlet channels, and is located beneath the array of gate structures. A back gate dielectric material portion lines exposed surfaces within the vertical inlet channel, the vertical outlet channel and the horizontal channel. | 2016-06-30 |
20160187289 | METHODS AND APPARATUS FOR MEASURING ANALYTES - A method is provided to sample a sensor array. The method can include measuring a waveform associated with a chemical event occurring on the sensor array. The waveform can include at least one region associated with expected measured values and at least one region associated with unpredictable measured values. The method can also include applying a first frame averaging to the at least one region associated with the expected measured values. Here, a first number of frames can be included in the first frame averaging. Further, the method can include applying a second frame averaging to the at least one region associated with the unpredictable measured values, where a second number of frames can be included in the second frame averaging. The second number of frames can be less than the first number of frames. | 2016-06-30 |
20160187290 | METHOD AND APPARATUS FOR ANALYZING A TARGET MATERIAL - Aspects of the subject disclosure may include, for example, an apparatus having a material having a through-hole, a gate coupled to the material for controlling a charge concentration of the material, a sensor, and a controller coupled to the material, the gate and the sensor. The controller can perform operations including applying a first voltage potential to the material to induce a flow of current in the material, applying a second voltage potential to the gate to adjust the charge concentration of the material, and receiving sensing data from the sensor responsive to a change in electrical properties of the material caused by a target traversing the first through-hole of the material. The through-hole causes a plurality of structural portions of the target to be misaligned with a direction of the flow current in the material. Additional embodiments are disclosed. | 2016-06-30 |
20160187291 | GLUCOSE TEST STRIP WITH INTERFERENCE CORRECTION - A test strip comprising a base layer, the base layer having an optional hematocrit anode configured to determine a value corresponding to a hematocrit level of a fluid sample, wherein the hematocrit anode may be coated with a reagent, an interference anode configured to determine a value corresponding to a measurement of an interference caused by one or more oxidizable substances in the sample fluid, wherein the interference anode electrode includes an interference reagent on its surface, a glucose anode, the glucose anode being configured to determine a glucose level in the fluid sample, wherein the glucose anode is covered with a reagent comprising a mediator and an analyte specific enzyme, and one or more cathodes in a cooperative relation with the hematocrit anode, the interference anode, and the glucose anode to measure the hematocrit level, the interference and the glucose level. | 2016-06-30 |
20160187292 | Gene Mutation Analyzer, Gene Mutation Analysis System, and Gene Mutation Analysis Method - An aspect of the present invention includes performing electrophoresis of a nucleic acid sample to be analyzed labeled for each base type, generating waveform data of detected intensity by detecting a label signal for the each base type, selecting another peak position for each peak position of the waveform data for each base type, calculating relative signal intensity of signal intensity in each position relative to the signal intensity in the other selected position, and analyzing existence of each base type in a base sequence coordinate position of the nucleic acid sample by comparing the relative signal intensity of the nucleic acid sample to be analyzed and the relative signal intensity of a known nucleic acid sample in each peak position. Accordingly, acquiring information about a gene mutation in trace amounts existing in a target gene region highly sensitively with high precision is realized. | 2016-06-30 |
20160187293 | ELECTROPHORESIS SYSTEM - An electrophoresis device where the end of the electrophoresis channel has a part that extends vertically. The electrophoresis channel includes a first access port at one end of the channel and a second port at the other end of the channel, which are in the same horizontal plane. In this way, there is a less than 0.1% hydrostatic pressure differential between two ports and the performance of the device is improved. | 2016-06-30 |
20160187294 | MEASUREMENT DEVICE - According to one embodiment, a measurement device includes a first chamber, a second chamber, a partition provided between the first and second chambers, a through hole which is provided in the partition and with which the first chamber and the second chamber communicate each other, a first electrode provided in the first chamber, and a second electrode provided in the second chamber. The first electrode and the second electrode contain different metals or alloys at least in surface layers thereof, and a relationship of Ia2016-06-30 | |
20160187295 | SEMICONDUCTOR MICRO-ANALYSIS CHIP AND METHOD OF MANUFACTURING THE SAME - According to one embodiment, a semiconductor micro-analysis chip for detecting particles in a sample liquid includes a semiconductor substrate, a flow channel provided on a surface portion of the semiconductor substrate to allow the sample liquid to flow in the channel, and including a cap layer to cover at least an upper portion of the flow channel, a micropore provided at a part of the flow channel to allow the particles in the sample liquid to pass through the micropore, and a plurality of holes provided in the cap layer. | 2016-06-30 |
20160187296 | Ion Mobility Method and Apparatus - A method and system for performing an ion mobility based analysis that ionizes the components of a sample into ions; provides a field asymmetric waveform ion mobility or differential mobility spectrometry ion mobility based filter that comprises at least two electrodes, the at least two electrodes being spaced apart such that a constant sized gap is formed there between, through which a drift gas flows; introducing said ions into the drift gas, wherein said drift gas also comprises a mixture of liquid modifiers. | 2016-06-30 |
20160187297 | METHOD AND PORTABLE ION MOBILITY SPECTROMETER FOR THE DETECTION OF AN AEROSOL - A portable ion mobility spectrometry apparatus ( | 2016-06-30 |
20160187298 | PROBE AND MANUFACTURING METHOD THEREOF - Disclosed herein is a probe including: an acoustic module including a piezoelectric layer configured to generate ultrasonic waves, a matching layer configured to reduce a difference in acoustic impedance between the piezoelectric layer and an object, and a backing layer configured to absorb ultrasonic waves generated by the piezoelectric layer and transmitted backward from the piezoelectric layer; a plurality of attenuation layers provided at both edges of the upper surface of the acoustic module, and configured to attenuate ultrasonic waves generated by the acoustic module; and a lens layer disposed to cover the upper surfaces of the attenuation layers, and configured to focus ultrasonic waves transmitted forward from the piezoelectric layer at a predetermined point. | 2016-06-30 |
20160187299 | METHOD FOR CREATING DEVICE - A method for creating an electronic device including a semiconductor substrate, an element unit, a through wiring line, and a wiring portion includes forming interstitial via holes in a first surface of the substrate, forming a first insulating film on the inner walls of the via holes, forming openings that reach the first insulating film on the bottoms of the via holes from a second surface of the substrate, forming a second insulating film on the bottoms of the openings, forming a through wiring line in the via holes, forming an element unit that electrically connects the through wiring line, reducing the thickness of the substrate from the second surface so that the second surface becomes flush with the second insulating film on the bottoms of the openings, and forming a wiring portion, on the second insulating film, that electrically connects to the through wiring line. | 2016-06-30 |
20160187300 | ELECTROMAGNETIC TRANSDUCER - An electromagnetic transducer is disclosed. An example electromagnetic transducer may be provided for a fluid parameter meter. The example electromagnetic transducer may include at least one permanent magnet, a first armature mounted in magnetic cooperation with the permanent magnet, and a second armature mounted in magnetic cooperation with the permanent magnet. The first and the second armatures are arranged to interact with a third armature in magnetic cooperation with the first armature and the second armature. The example electromagnetic transducer may also include at least one electric coil mounted in cooperation with the magnetic field so that electric current through the electric coil to vary the vibratory forces. The example electromagnetic transducer may include an electronic module to control electric current and vibratory forces on a vibrating element of the fluid parameter meter. | 2016-06-30 |
20160187301 | ULTRASONIC PROBE APPARATUS AND ULTRASONIC IMAGING APPARATUS USING THE SAME - An ultrasonic probe apparatus and an ultrasonic imaging apparatus are disclosed. The ultrasonic probe apparatus includes: an ultrasonic transducer configured to output an electrical signal upon receiving ultrasonic waves; a sound absorption unit, one surface of which is an installation surface of the ultrasonic transducer and is electrically connected to the ultrasonic transducer; a first electronic circuit electrically connected to the sound absorption unit; and a substrate connection unit disposed between the sound absorption unit and the first electronic circuit, configured to electrically interconnect the first electronic circuit and the sound absorption unit. The ultrasonic imaging apparatus includes the above ultrasonic probe and a main body. | 2016-06-30 |
20160187302 | WAFER CLAMP DETECTION BASED ON VIBRATION OR ACOUSTIC CHARACTERISTIC ANALYSIS - A workpiece clamping status detection system and method for detecting a clamping state of a clamping device is provided. A clamping device having a clamping surface is configured to selectively clamp a workpiece to the clamping surface. The clamping device may be an electrostatic chuck or a mechanical clamp for selectively securing a semiconductor wafer thereto. A vibration-inducing mechanism is further provided, wherein the vibration-inducing mechanism is configured to selectively vibrate one or more of the clamping device and workpiece. A vibration-sensing mechanism is also provided, wherein the vibration-sensing mechanism is configured to detect the vibration of the one or more of the clamping device and workpiece. Detection of clamping status utilizes changes in acoustic properties, such as a shift of natural resonance frequency or acoustic impedance, to determine clamping condition of the workpiece. A controller is further configured to determine a clamping state associated with the clamping of the workpiece to the clamping surface, wherein the clamping state is associated with the detected vibration of the one or more of the clamping device and workpiece. | 2016-06-30 |
20160187303 | METHOD AND ROAD MANAGEMENT PLATFORM FOR MANAGING ROAD MAINTENANCE - A road condition acquiring method using a mobile device includes acquiring a road condition and a current geographic position information regarding the road condition, when a vibration sensor built-in the vehicle senses a vibration value, when the vibration value is larger than a predetermined value, the road condition and the current geographic position information is sent to a road management platform. And road maintenance management method and platform are also provided. | 2016-06-30 |
20160187304 | APPARATUS AND METHOD FOR INTRODUCING SAMPLE INTO A SEPARATION UNIT OF A CHROMATOGRAPHY SYSTEM WITHOUT DISRUPTING A MOBILE PHASE - A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit. | 2016-06-30 |
20160187305 | CURRENT-EFFICIENT SUPPRESSOR AND PRETREATMENT DEVICE AND METHOD - An apparatus for treating an aqueous sample stream includes analyte ions. The apparatus comprises an ion exchange barrier; a sample stream flow channel; an ion receiving stream flow channel adjacent to the sample stream flow channel and separated therefrom by said first ion exchange bather. Stationary flow-through ion exchange packing is disposed in the sample flow channel of the same charge as the ion exchange bather. The ion exchange packing comprises a mixture of a first ion exchange portion with strong ionizable groups and a second ion exchange portion with weak ionizable groups of the same charge. First and second electrodes are in electrical communication with the sample stream flow channel and ion receiving flow channel. | 2016-06-30 |
20160187306 | VIAL CAP AND METHOD FOR REMOVING MATRIX COMPONENTS FROM A LIQUID SAMPLE - A vial cap for removing a matrix component from a liquid sample is described. The vial cap includes a cap body, an inlet portion, and an outlet portion. The cap body is configured to have a slidable gas and liquid seal with a side wall of a sample vial. The inlet portion includes a counterbore section that holds a filter plug. The filter plug includes a polyethylene resin and a material selected from the group consisting of an ion exchange material and a reversed-phase material. The vial cap is adapted for solid phase extraction for use in an autosampler with a plurality of sample vials. | 2016-06-30 |
20160187307 | ONE REACTOR POST COLUMN REACTION GC/FID SYSTEM USING Ru CATALYST - Provided is a system comprising a conduit from a gas chromatograph column to a reactor comprising a Ru catalyst, with a hydrogen feed conduit for providing hydrogen to the conduit from the gas chromatograph column, and a conduit from the reactor to an FID detector. This allows one to practice a method for the detection and quantification of organic molecules from a gas chromatograph which comprises passing the effluent from a gas chromatograph column to a reactor comprising a Ru catalyst; adding hydrogen to the effluent prior to the effluent reaching the catalyst; reacting the effluent from the gas chromatograph column in the reactor to reduce all organic containing molecules to CH | 2016-06-30 |
20160187308 | METHOD AND SYSTEM FOR DETECTING BORON IONS USING ION CHROMATOGRAPHY FOR ONLINE MONITORING OF STEAM GENERATOR TUBE LEAKAGE IN LIGHT WATER REACTOR - The present invention relates to an online leakage monitoring technique of a steam generator tube for monitoring leakage of the steam generator tube by analyzing concentration of an extremely small amount of boron ions in the secondary side solution of the steam generator in which a variety of ions are mixed, and the present invention is effective in that concentration of an extremely small amount of boron ions can be accurately detected, maintenance is convenient and durability is improved since analysis time is reduced considerably and operation pressure is lowered greatly by using ion chromatography provided with a boron trapping column optimized for trapping an extremely small amount of boron ions and a deionization water supplier for rising a sample line, instead of general ion chromatography provided with a concentration column and a separation column. | 2016-06-30 |
20160187309 | POST-STEAM STERILIZATION MOISTURE-INDICATING METHODS AND ARTICLES - Methods for detecting moisture are described. The methods include sequential steps: (a) subjecting an article comprising a reversible moisture-indicating medium to steam sterilization in a steam sterilizer to produce a sterilized article; (b) subjecting the sterilized article to drying to reduce moisture in the sterilized article; (c) removing the sterilized article from the steam sterilizer; and (d) determining the level of moisture in the sterilized article after step (c) based on at least one property of the moisture-indicating medium. Packages comprising reversible steam-sterilization-compatible moisture-indicating media, including post-steam sterilization wet pack indicators, are also described | 2016-06-30 |
20160187310 | Image Based Surveillance System - A method incorporating the steps of a display of a gas detection system depicting a map of a predetermined geographic area and a plurality of portable gas detectors on the map via a respective gas detector icon, a programmed processor of the gas detection system identifying a number of gas detectors of the plurality of portable gas detectors within a predetermined portion of the area depicted on the display, the number exceeding a threshold value and a programmed processor of the gas detection system replacing the icons of the identified gas detectors within the portion with a group icon. | 2016-06-30 |
20160187311 | Respirometer - We describe a floating respirometer, in particular for monitoring an activated sludge vessel of a sewage treatment plant. The device comprises: a buoyancy device to allow the respirometer to float in an aqueous liquid; a respirometer chamber, supported by the buoyancy device and arranged such that, when the respirometer is floating in said aqueous liquid, said chamber is partially filled with said aqueous liquid and defines an enclosed head space above said aqueous liquid; and a gas sensor in gaseous communication with said head space. | 2016-06-30 |
20160187312 | METHOD OF RESOLVING CONTRIBUTION RATIO TO SOIL CONTAMINATION BY PLURALITY OF POLLUTERS THROUGH SEQUENTIAL EXTRACTION SCHEME AND STABLE ISOTOPE ANALYSIS SCHEME - In a method of resolving a contribution ratio to soil contamination by a plurality of polluters through a sequential extraction scheme and a stable isotope analysis scheme, Pb stable isotopes are eluted at 5 types of “cation exchange fraction”, “carbonate fraction”, “iron-oxide and manganese hydroxide-fraction”, “organic matters and sulfide fraction”, and “residual fraction” existing at other types and separated from each other in each step. The Pb stable isotopes obtained in each step are analyzed. | 2016-06-30 |
20160187313 | Core Sample Analysis System with Conditioned Environment - A system for analyzing a cote sample from a wellbore, where the analysis takes place in the field and proximate the wellbore. The system includes a trailer with a unit for scanning the core sample and obtaining information within the sample. The unit is housed in a cabinet having a cabinet interior that is maintained at a set temperature and humidity with conditioned air. The cabinet also has sidewalls that define a pressure barrier between the inside of the cabinet and an isolation space that is between the cabinet and inner surface of the trailer. The unit includes a manipulator system for moving the core sample through a rotating scan source in the scanning unit. A sample enclosure provides a barrier between the ambient zone surrounding the sample and the isolation space in the cabinet. | 2016-06-30 |
20160187314 | METHODS FOR AUTHENTICATION AND IDENTIFICATION OF PETROLEUM PRODUCTS - A method is provided that associates a taggant with a product to produce a signature product. The taggant, when associated with the signature product, is visually undetectable; and comprises one or more amide compounds (e.g., a taggant array that comprises two or more amide compounds). The method also identifies the taggant in the signature product by an immunoassay specific for the taggant; maps the taggant of the signature product to a batch code of the signature product; obtains a test product to determine authenticity or identity of the test product; identifies the presence or absence of a taggant in the test product by an immunoassay specific for the taggant; and compares results of the immunoassay carried out on the test product with results of the immunoassay carried out on the signature product to determine authenticity or identity of the test product. Lubricating engine oils are provided containing the taggant. | 2016-06-30 |
20160187315 | METHODS FOR DETERMINING CONDITION AND QUALITY OF PETROLEUM PRODUCTS - A method is provided for determining the condition or quality of a product. The method involves adding to the product a taggant in which the taggant exhibits degradation in response to one or more stimuli; carrying out an immunoassay specific for the taggant to determine degradation of the taggant; and determining the condition of the product based on the degradation of the taggant. A method is provided for monitoring degradation or quality of a product. The method involves adding to the product a taggant in which the taggant exhibits degradation in response to one or more stimuli; and carrying out an immunoassay specific for the taggant to determine degradation of the taggant. The method further involves identifying the condition of the product based on the degradation of the taggant. Lubricating engine oils are provided containing the taggant. | 2016-06-30 |
20160187316 | NOVEL MICROFLUIDIC DEVICES FOR DIAGNOSING RED BLOOD CELLS ABNORMALITIES, AND METHODS USING SAME - The present invention includes a device useful for evaluating the size, shape, surface texture, mobility, rigidity, flexibility, tensile resistance or turnover rate of red blood cells in a blood sample from an individual. The device of the present invention may be used to determine if the individual suffers from a red blood cell abnormality, such as sickle cell disease. | 2016-06-30 |
20160187317 | METHOD OF IDENTIFYING ADIPOSE STEM CELLS - Disclosed is a method of identifying the origin of adipose-derived stem cells, comprising detecting at least one cell-surface marker selected from a group consisting of CD 10, CD141, CD 142 and CD200. Also disclosed are methods of determining adipogenic capability of a cell capable of adipogenesis by determining the presence of CD 10 or CD200. | 2016-06-30 |
20160187318 | SCREENING ASSAYS BASED ON MAG AND/OR ABHD6 FOR SELECTING INSULIN SECRETION PROMOTING AGENT - The present application relates to a method of characterizing an agent's ability to increase insulin secretion in a subject. The method comprises determining whether the agent is able to modulate MAG level at the inner surface of the cytoplasmic membrane of a cell and/or ABHD6 activity. The agent is characterized as having the ability to increase insulin secretion in the subject when it is capable of upregulating MAG level at the inner surface of the cytoplasmic membrane and/or downregulating ABHD6 activity. | 2016-06-30 |
20160187319 | CELL DEATH-INDUCING AGENT, CELL GROWTH-INHIBITING AGENT, AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISEASE CAUSED BY ABNORMAL CELL GROWTH - An agent for inducing cell death and/or inhibiting cell growth for cancer cells. The agents of the present invention comprise, as active ingredients, a drug inhibiting GST-π and a drug inhibiting a homeostasis-related protein that exhibits synthetic lethality when inhibited together with GST-π. The homeostasis-related protein can be a cell cycle-regulating protein or an anti-apoptosis-related protein. | 2016-06-30 |
20160187320 | ASSAY FOR SCREENING COMPOUNDS THAT SELECTIVELY DECREASE THE NUMBER OF CANCER STEM CELLS - The present invention provides, inter alia, a method for identifying an agent that selectively decreases the number of cancer stem cells (CSCs). This method includes (a) contacting a CSC from a population of cells with a candidate agent; and (b) determining whether the candidate agent reduces the survival or growth of the CSC or increases differentiation of the CSC relative to a CSC that has not been contacted with the candidate agent. The method may be used as a high throughput screen. | 2016-06-30 |
20160187321 | INDUCED EXPRESSION OF PROTEINS IN INSECT CELLS - The present invention concerns insect cells that have been induced to express one or more proteins by contact with one or more insect hormones or one or more modulators of the G protein-coupled receptor signaling pathway, compositions comprising such insect cells, a method for inducing protein expression in insect cells, and a screening method using such insect cells. | 2016-06-30 |
20160187322 | FELINE BITTER TASTE RECEPTORS AND METHODS - A family of novel feline bitter taste receptors, referred to as feline TAS2R (fTAS2R), are disclosed herein. Isolated polynucleotides encoding the novel feline bitter taste receptors and chimeric polypeptides are also disclosed, as are expression vectors and host cells for expression of the novel feline bitter taste receptors. Methods of identifying compounds that bind to the novel feline bitter taste receptors and modulate their activity are disclosed. | 2016-06-30 |
20160187323 | SYSTEM FOR SCREENING PARTICLES - Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function. | 2016-06-30 |
20160187324 | Antibody Conjugates - Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification. | 2016-06-30 |
20160187325 | METHOD AND KIT FOR MEASURING MODIFIED NUCLEOBASE USING HETEROGENEOUS NUCLEIC ACID PROBE - The present invention provides a technique that suppresses a background value of a detection signal to construct an immunoassay system that detects a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase comprising incubating a nucleic acid sample (e.g., a sample containing a target DNA containing the modified nucleobase) and a heterogeneous nucleic acid probe (e.g., an RNA probe) in a solution and measuring the modified nucleobase using an antibody against the modified nucleobase in the obtained solution. The present invention also provides a kit for measuring a modified nucleobase comprising a heterogeneous nucleic acid probe and an antibody against the modified nucleobase. | 2016-06-30 |
20160187326 | CELL DETECTION WITH CONJUGATES HAVING AN ENZYMATICALLY RELEASABLE DETECTION MOIETY - The invention is directed to a method for detecting a target moiety in a sample of biological specimens by:
| 2016-06-30 |
20160187327 | DIAGNOSTIC ASSAY USING PARTICLES WITH MAGNETIC PROPERTIES - A novel system for the analysis of molecules and cells, comprising clusters where a non-magnetic particle is supplemented with magnetic particles to form a characteristic pattern, fingerprint or bar code. Methods and devices for formation of such particles are also disclosed. | 2016-06-30 |
20160187328 | DEVICES, SYSTEMS, AND METHODS FOR MULTIPLEX ALLERGEN TESTING - Multiplex devices, systems, and associated methods for assaying a biological sample for an allergen-binding molecule are disclosed and described. | 2016-06-30 |
20160187329 | METHOD OF AMPLIFYING DETECTION LIGHT USING LIGHT-REFLECTING MATERIAL IN IMMUNOCHROMATOGRAPHY - The present invention intends to provide an immunochromatographic test piece that makes it possible to achieve both highly sensitive detection of a substance to be detected and a simple test piece structure, which are usually difficult to be made compatible with each other. The immunochromatographic test piece is an immunochromatographic test piece comprising a membrane on which a capture substance being a ligand that bonds to a substance to be detected is immobilized, wherein insoluble carrier particles to which a ligand that bonds to the substance to be detected is bound are used and accumulated by being captured with the capture substance immobilized on the membrane, the membrane is irradiated with light to detect light emitted from a portion where the insoluble carrier particles are accumulated or light emitted from a portion surrounding and other than the portion where the insoluble carrier particles are accumulated, thereby measuring the substance to be detected, and a light-reflecting material is provided on a side of the membrane opposite to a side irradiated with light. | 2016-06-30 |
20160187330 | CENTRIFUGE AND METHOD FOR CENTRIFUGING A REACTION VESSEL UNIT - A centrifuge for cleaning a reaction vessel unit, having a rotor for holding at least one reaction vessel unit with its opening(s) directed outwardly, a motor for rotating the rotor around a rotation axis, a housing having a substantially cylindrical inner surface, wherein a drain is provided for discharging fluid expelled from the reaction vessel unit, wherein a gap is provided between the inner surface and the rotor so that by rotating the rotor a wind is generated which drives the expelled fluid on the inner surface to the drain wherein an aspiration pump is connected to the drain for discharging fluid. | 2016-06-30 |
20160187331 | METHOD FOR ACTIVE DETECTION BIO MOLECULES - Provided is a method of detecting biomolecules. The method of detecting biomolecules includes accommodating a plurality of metal particles to which a first molecule specifically binding to target biomolecules is attached, a plurality of magnetic particles to which a second molecule specifically binding to target biomolecules is attached, and the biomolecules; applying a magnetic field to exert an attractive force on magnetic particles; filtering one or more among metal particles, biomolecules and metal particle-binding biomolecules, on which an attractive force is not exerted; and exerting an attractive force on the metal particles of a first assembly in which both of the metal particles and the magnetic particles are bound to the biomolecules by applying an electric field and detecting the metal particles. | 2016-06-30 |
20160187332 | SYSTEMS AND METHODS FOR DETECTING A SUBSTANCE IN BODILY FLUID - Various devices, systems and methods for determining a parameter of and/or detecting chemical and biological substances in bodily fluid are described herein. A device or system may include a substrate. An active sensor having an electrical characteristic and/or a control sensor may be disposed on the substrate. In certain variations, a differential between a first signal from the active sensor, and a second signal from the control sensor may be used to determine a parameter of the chemical or biological substance in the sample of bodily fluid. | 2016-06-30 |
20160187333 | PLANAR WAVEGUIDE BASED CARTRIDGES AND ASSOCIATED METHODS FOR DETECTING TARGET ANALYTE - A cartridge for processing a sample includes (a) a planar waveguide with upper and lower planar surfaces defining an optical axis therebetween, wherein the upper planar surface has a plurality of capture molecules bound thereto, (b) a lens portion, coupled to the planar waveguide, for focusing and refracting a light beam propagating parallel to, but offset from, the optical axis such that the light beam couples into the planar waveguide and propagates therein along the optical axis at a non-zero, internal propagation angle β relative to the upper planar surface, and (c) a sample chamber for positioning the sample in contact with the plurality of capture molecules such that a target analyte of the sample is detectable through (i) an assay involving the target analyte and the capture molecules and (ii) evanescent illumination of the assay using the light beam within the planar waveguide. | 2016-06-30 |
20160187334 | SYSTEMS AND METHODS FOR DETECTING A SUBSTANCE IN BODILY FLUID - Various devices, systems and methods for determining a parameter of and/or detecting chemical and biological substances in bodily fluid are described herein. A device or system may include a substrate. An active sensor having an electrical characteristic and/or a control sensor may be disposed on the substrate. In certain variations, a differential between a first signal from the active sensor, and a second signal from the control sensor may be used to determine a parameter of the chemical or biological substance in the sample of bodily fluid. | 2016-06-30 |
20160187335 | METHOD AND DEVICE FOR DETECTING SAMPLE - According to one embodiment, a method for detecting a sample includes preparing a device for detecting a sample, the device including a measurement cassette, a first chamber formed by partitioning the cassette with a partition wall, a through-hole provided in the partition wall, a first electrode provided in the cassette, and a second electrode provided in the cassette, introducing a reagent and a sample containing a measuring object substance into the first chamber, introducing a conductive liquid into the second chamber, supplying current to the through-hole, allowing the measuring object substance whose surface is bound to and is covered by the tag particles via the capture substance in the first chamber to pass through the through-hole, and detecting presence of the measuring object substance. | 2016-06-30 |
20160187336 | Microfluidic System and Method for Isolating and Quantifying at Least One Sub-Population of Cells From a Population of Cells - Disclosed are a microfluidic system ( | 2016-06-30 |
20160187337 | ASSAY FOR JC VIRUS ANTIBODIES - The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject. | 2016-06-30 |
20160187338 | METHODS AND COMPOSITIONS FOR DETECTING COAGULATION INHIBITORS - The present invention provides a method of identifying a coagulation inhibitor in a sample, comprising: a) contacting a first portion of the sample with a substrate and thrombin; b) contacting a second portion of the sample with a substrate and a2M-thrombin (thrombin caged in alpha-2-macroglobulin); c) contacting a third portion of the sample with a substrate and coagulation factor Xa; d) contacting a fourth portion of the sample with a substrate and a2M-Xa (factor Xa caged in alpha-2-macroglobulin); and e) assaying for cleavage of the substrate in (a), (b), (c) and (d) above, wherein cleavage of the substrate in (b) and (d) and no cleavage in (a) and (c) identifies heparin in the sample; cleavage of the substrate in (a), (b) and (d) and no cleavage in (c) identifies low molecular weight heparin in the sample; cleavage of the substrate in (a) and (b) and no cleavage in (c) and (d) identifies rivaroxaban in the sample, and cleavage of the substrate in (c) and (d) and no cleavage in (a) and (b) identifies dabigatran in the sample. | 2016-06-30 |
20160187339 | Biomarker and Method for Determining an Oxidative Stress Level - The present invention relates to a biomarker and a method for determining an oxidative stress level in a biological sample, which employs co-factor-dependent oxidative stress parameters, as well as a kit adapted for carrying out such a method. In one aspect the co-factor is tetrahydrobiopterin. | 2016-06-30 |
20160187340 | Compositions, Kits, and Methods for the Modulation of Immune Responses Using Galectin-1 - The present invention is based, in part, on the discovery that galectin-1 (Gal1) plays a role in immune disorders, including Hodgkin lymphoma. Accordingly, the invention relates to compositions, kits, and methods for detecting, characterizing, modulating, preventing, and treating immune disorders, e.g., Hodgkin lymphoma. | 2016-06-30 |
20160187341 | KERATINS AS BIOMARKERS FOR CERVICAL CANCER AND SURVIVAL - The current disclosure provides methods for detecting and analyzing KRT4 and KRT17 expression in a sample obtained from a test subject. The current disclosure pertains to methods and kits for identifying a mammalian subject with cervical cancer or non-cancerous lesions of the cervix. The current disclosure further provides methods and kits for determining the likelihood of survival or treatment outcome of a subject having cervical cancer by determining the expression level of KRT17 in a sample. | 2016-06-30 |
20160187342 | DNA Aptamer Specifically Binding to EN2 (Engrailed-2) and Use Thereof - The present invention relates to a DNA aptamer specifically binding to EN2 (Engrailed-2), a biosensor for diagnosing prostate cancer having the same, and a method of diagnosing prostate cancer. A strong binding force and excellent specificity of the DNA aptamer of the present invention and the biosensor using the same with respect to EN2 proteins were identified. A detection specificity problem of a prostate-specific antigen (PSA) test used for prostate cancer diagnosis of the related art was addressed. Therefore, the present invention is expected to be beneficially used for early diagnosis of prostate cancer more effectively and increase diagnostic accuracy. | 2016-06-30 |
20160187343 | COMPOSITIONS AND METHODS FOR IDENTIFYING A RISK OF CANCER IN A SUBJECT - Disclosed herein are compositions and methods for determining a risk of cancer, such as head and neck squamous cell carcinoma, in a subject using a bodily fluid sample from the subject and assays for markers such as solCD44 and total protein. Also disclosed are methods of treating a subject based on said risk. Methods of determining the efficacy of a cancer treatment are also disclosed. | 2016-06-30 |
20160187344 | METHOD OF MEASURING CANCER RELATED SUBSTANCES BY RAMAN SPECTROSCOPY - A method for measuring cancer related substances including cancer cell-derived free DNA by Raman spectroscopy, involving steps for preparing a biochip having a meso-crystal region of silver oxides containing a silver peroxide, adding a blood serum or a biological sample solution dropwise onto the meso-crystal region of said biochip, selectively trapping the cancer-related substances having a positive charge in the sample, irradiating the trapped cancer-related substance with an exciting laser light and detecting a surface enhanced Raman scattering therefrom, wherein cancer diseases are evaluated on the basis of the intensity of the Surface Enhance Raman Scattering (SERS). In the carbon-specific D band and G band in the Raman scattering spectrum, a characteristic peak spectrum of the cancer-related substance can be detected in the proximity of the methyl group characteristic of 2900 cm | 2016-06-30 |
20160187345 | METHODS FOR DETECTING AND DETERMINING LEVELS OF MONOLIGNOL ESTER CONJUGATES INCORPORATED INTO LIGNIN AND COMPOUNDS RELATING THERETO - Described is a method of detecting and/or determining levels of incorporation of monolignol ferulate conjugate esters into lignin by derivatizing the lignin, reductively cleaving the lignin, labeling the cleavage products, and then detecting cleavage products derived from monolignol ester conjugates via differential attachment of the label. | 2016-06-30 |
20160187346 | PYRITE SHRINK-FILM LAMINATE AS A HYDROXYL RADICAL GENERATOR - Disclosed are hydroxyl radial generating devices, comprising: a substrate layer; and a pyrite layer configured to produce hydroxyl radicals. Another aspect relates to a method for producing a hydroxyl radical generating device, comprising: providing a polymeric substrate layer; placing a layer of pyrite on a surface of the polymeric substrate layer to form a multi-layer structure; and applying heat to the multi-layer structure such that at least the surface of the polymeric substrate layer contracts; wherein the layer of pyrite contracts to a lesser extent than the surface of the polymeric substrate layer providing a textured surface comprising the pyrite layer. Also disclosed is a method of analysis, comprising: placing a solution comprising a biological substance on a sample site of a hydroxyl generating device comprising a surface of pyrite; incubating the solution; and analyzing a sample including proteolytic fragments of the biological substance. | 2016-06-30 |
20160187347 | BIOMARKER TEST FOR PREDICTION OR EARLY DETECTION OF PREECLAMPSIA AND/OR HELLP SYNDROME - Disclosed are specific biomarkers that allow for early testing of preeclampsia/HELLP syndrome. Thus, a method is provided predicting preeclampsia in a pregnant woman. Also disclosed is a kit comprising means for assaying a sample from a pregnant woman for the concentrations of the specific biomarkers. | 2016-06-30 |
20160187348 | Methods for Detecting Renal Disease - The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes methods for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease. | 2016-06-30 |
20160187349 | Proteomic Biomarkers of Sepsis in Elderly Patients - A proteomic expression platform to identify age-related sepsis risk is disclosed using patients with community-acquired pneumonia. A semi-quantitative plasma proteomics workflow was applied which incorporated tandem immuno affinity depletion, iTRAQ labeling, strong cation exchange fractionation, and nanoflow-liquid chromatography coupled to high resolution mass spectrometry. A protein profile was determined that exhibit statistically significant differences in expression levels amongst patients with severe sepsis as a function of age. Representative pathways that are differentially-expressed include, but are not limited to, acute phase response, coagulation signaling, atherosclerosis signaling, lipid metabolism, and production of nitric oxide/reactive oxygen species. | 2016-06-30 |
20160187350 | CLEAVABLE PROBES FOR ISOTOPE TARGETED GLYCOPROTEOMICS AND METHODS OF USING THE SAME - Methods for producing isotopically-labelled peptides are provided. Aspects of the method include: contacting a sample including a metabolically tagged protein with a cleavable probe to produce a probe-protein conjugate; separating the probe-protein conjugate from the sample; digesting the probe-protein conjugate to produce a probe-peptide conjugate; and cleaving a cleavable linker to release an isotopically labelled peptide. The method may further include: identifying a predetermined isotopic pattern in a mass spectrum; determining an amino acid sequence of the isotopically labelled peptide; and identifying the site of protein glycosylation based on the determined amino acid sequence. Also provided are cleavable probes for practicing the subject methods, described by the Formula: A-L-(M-Z) where A is an affinity tag, L is a cleavable linker, M is an isotopic label and Z is a chemoselective tag capable of cross-linking a metabolically tagged protein. Compositions and kits for practicing the subject methods are also provided. | 2016-06-30 |
20160187351 | METHOD FOR THE ABSOLUTE QUANTIFICATION OF NATURALLY PROCESSED HLA-RESTRICTED CANCER PEPTIDES - The present invention relates to a method for the absolute quantification of naturally processed HLA-restricted cancer peptides, i.e. the determination of the copy number of peptide(s) as presented per cell. The present invention can not only be used for the development of antibody therapies or peptide vaccines, but is also highly valuable for a molecularly defined immuno-monitoring, and useful in the processes of identifying of new peptide antigens for immunotherapeutic strategies, such as respective vaccines, antibody-based therapies or adoptive T-cell transfer approaches in cancer, infectious and/or autoimmune diseases. | 2016-06-30 |
20160187352 | METHODS AND KITS FOR PREDICTING THE RISK OF HAVING A CARDIOVASCULAR DISEASE OR EVENT - The present invention relates to a method for diagnosing a cardiovascular event or disease in a subject by measuring sTREM-1 level in a sample. | 2016-06-30 |
20160187353 | Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease (COPD) - Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD. | 2016-06-30 |
20160187354 | DIAGNOSTIC MARKERS FOR MULTIPLE SCLEROSIS - Biomarkers and uses thereof, as well as methods for using same for diagnosing first-attack multiple sclerosis are described herein. | 2016-06-30 |
20160187355 | DETECTION AND TREATMENT OF LRP4-ASSOCIATED NEUROTRANSMISSION DISORDERS - The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders. | 2016-06-30 |
20160187356 | METHOD FOR ENRICHMENT AND SEPARATION OF SPINAL FLUID GLYCOPROTEIN, METHOD FOR SEARCHING FOR MARKER FOR CENTRAL NERVOUS SYSTEM DISEASES WHICH UTILIZES THE AFOREMENTIONED METHOD, AND MARKER FOR CENTRAL NERVOUS SYSTEM DISEASES - The purpose of the present invention is to develop: a method for selectively separating a glycoprotein derived from the central nervous system from a body fluid or a central nervous system cell; and a method for searching for an index marker for central nervous system diseases, which utilizes the aforementioned method. A protein derived from the central nervous system, which occurs in a trace amount in a body fluid or a central nervous system cell, can be selectively enriched by a two-stage separation procedure comprising removing a glycoprotein having sialic acid at a non-reducing terminal thereof from the body fluid or the central nervous system cell and then separating a glycoprotein having N-acetylglucosamine at a non-reducing terminal thereof. | 2016-06-30 |