26th week of 2012 patent applcation highlights part 50 |
Patent application number | Title | Published |
20120164587 | HYBRID LITHOGRAPHIC METHOD FOR FABRICATING COMPLEX MULTIDIMENSIONAL STRUCTURES - Lithographic Method. The method fabricates complex structures and includes depositing a photoresist onto a substrate, the photoresist including a predominantly thermal band of optical absorption possibly due to the incorporation of a doping agent. A three-dimensional pattern is generated within the resist using a first wavelength of light to effect activation of a photoinitiator to produce a latently photostructured resist. Focused laser spike annealing of the photostructured resist with a second wavelength of light selected to be absorbed by the thermally absorbing band to accelerate the photoinduced reaction in the resist is provided. Three-dimensional direct writing may be performed within the resist to define features not part of the interference pattern and the resist is developed to produce the complex structure. | 2012-06-28 |
20120164588 | Reverse Flow Regenerative Apparatus and Method - An exemplary embodiment provides a regenerative burner apparatus. The apparatus includes a burner housing having a gas channel and a single-stage heat regenerator equipped with a housing enclosing a fluid-porous heat regenerative media bed. A first gas passageway in the housing directly interconnects the gas channel and the lower surface of the media bed. A second gas passageway in the housing interconnects an opening in the housing communicating with the exterior and the upper surface of the media bed. This arrangement allows hot waste combustion gases to pass upwardly through the media bed so that any condensable contaminant in the gases condenses to a liquid and flows out of the bed under gravity before becoming solid and clogging the bed. The liquid contaminant may then be removed from the regenerator from a position below the media bed. | 2012-06-28 |
20120164589 | OPTICAL COMBUSTOR PROBE SYSTEM - The present application provides an optical probe system for use with a combustion flame in a combustion chamber. The optical probe system may include a number of optical probes fixedly attached about the combustion chamber and positioned such that the optical probes collect light generated by the combustion flame in a field of view of each of the optical probes. One or more components external to the combustion chamber may produce and analyze signals indicative of the light generated by the combustion flame in the field of view of each of the optical probes. | 2012-06-28 |
20120164590 | Radiant Burner - The invention relates to a burner, in particular a radiant burner, for the combustion of a gas mixture of fuel gas and an oxygen carrier gas, with a burner plate with passage channels for the throughflow of the gas mixture from a mixing chamber side to a combustion side, wherein, on the combustion side, combustion channels with an enlarged cross-section compared with the passage channels connect to the passage channels, wherein flow obstacles for a contact with the combustion flame are arranged in the combustion channels and the flow obstacles are made of a material which has a higher thermal conductivity than the material of the burner plate. | 2012-06-28 |
20120164591 | Circulating Air Oven - The invention relates to a circulating gas oven incorporating a cooking surface wherein the cooking surface and air above are heated by a circulating gas system involving ducting and gas diffusers. The oven is portable and the cooking surface is made of ceramic or glass material. The ducting means and diffusers are adapted to create a laminar air flow. Foodstuff such as pizza can be cooked in a uniform manner. | 2012-06-28 |
20120164592 | Water Heating System - A method, including: receiving an instruction from a user of a hot water tank ( | 2012-06-28 |
20120164593 | SURGICAL DRILL GUIDE AND INDEX SYSTEM - A surgical drill guide for installing dental implants with predetermined angular alignment and rotational orientation for a dental prosthesis, formed of:
| 2012-06-28 |
20120164594 | Dental separator and matrix system for producing dental restorations - A dental separator device for applying pressure against adjacent teeth to separate the teeth from one another so that a dental restoration can be made. The separator device increases the interproximal space between the adjacent teeth giving the dental clinician improved visibility and working space. The invention also encompasses a flexible matrix band used for making the restoration. The matrix band is wrapped around the tooth to define a desired mold or shape for the restoration. | 2012-06-28 |
20120164595 | ARTICULATOR - A denture articulator is provided for coupling denture casts to allow for occlusal adjustment of the casts. The articulator includes a base, a cross bar, and a top. The casts are mounted to the top and base by cast holder seats or cast retainer seats for simulation of mastication and occlusal adjustment. The top allows a user to adjust the vertical location of the cast and also allows the user to adjust the elevation of the cast. | 2012-06-28 |
20120164596 | PERIODONTAL SCALER - A periodontal scaler is provided, comprising an arcuate shank and an arcuate blade. The arcuate blade being designed to conform to the roughly cylindrical surfaces found on the roots of teeth. This conforming feature of the instrument's blade increases its cleaning efficiency by maximizing contact between the blade's surface and the root, and guiding the instrument along the root by holding its convex edges within the concave shape of the blade. | 2012-06-28 |
20120164597 | DENTAL WEDGE WITH TOOTH GUARD AND METHOD OF RESTORING A TOOTH USING THE SAME - The present invention relates to dental devices utilized during the restoration of teeth and more particularly a dental wedge, for use in the inter-proximal space between adjacent teeth, the dental wedge comprising: a wedge body; and a guard releasably engaged to the wedge body, wherein the guard is transformable between a first position adjoined the wedge body and a second position disengaged from the wedge body. | 2012-06-28 |
20120164598 | DENTAL FULCRUM - A dental fulcrum comprised of soft material, such as foam, containing a slit for the insertion of incisors, and used as a pivot for scaling, or other treating, teeth by an oral hygienist or dentist. The dental fulcrum protects the fingers of an oral hygienist or dentist from calluses, or loss of sensitivity over time, while at the same time providing friction to reduce the risk of injury causes by fingers slipping on wet incisors. The device may be disposable or reusable, depending on the material used. Foam provides the additional benefit of absorbing saliva to further reduce the risk of slippage. | 2012-06-28 |
20120164599 | DENTAL FIXTURE, A DENTAL COMPONENT AND A DENTAL IMPLANT ASSEMBLY - The present invention relates to a dental fixture for insertion into a jawbone, said fixture comprising a holding portion which is arranged and configured for holding an engagement portion of a dental component, the holding portion being provided with an indexing section, wherein the shape of the mating contour of the indexing section in a first plane differ from the shape of the mating contour of the indexing section in a second plane being taken at a different height as seen in the apical-coronal extension of said fixture, and wherein the shapes of the mating contours of the indexing section at said first and second planes together allow a received dental component to be positioned in only one or two positions in relation to the fixture. The present invention also relates to a corresponding dental component and to dental implant assemblies. | 2012-06-28 |
20120164600 | SCREW HEAD - Fastening system including a screw component ( | 2012-06-28 |
20120164601 | Prosthetic Attachment - Improved prosthetic attachment ( | 2012-06-28 |
20120164602 | ABUTMENT FOR A DENTAL IMPLANT - An abutment ( | 2012-06-28 |
20120164603 | DENTAL IMPLEMENT HAVING LUMEN AND DISTAL THREADING - Apparatus is provided that includes a dental implement, which is shaped so as to define a lumen therethrough, a distal end of which lumen opens through at least one distal opening on a distal end of the dental implement; and a lateral external surface, at least a portion of which is shaped so as to define a screw thread that extends until the distal end of the dental implement. Other embodiments are also described. | 2012-06-28 |
20120164604 | UNEXTRACTED TOOTH ROOT CANAL FILLER AND DENTAL TISSUE REGENERATION METHOD FOR UNEXTRACTED TOOTH - Disclosed is a root canal filler for non-extracted tooth which causes no internal resorption or external resorption in a tooth with complete root formation, shows no odontoclast, and contributes to the regeneration of a dental tissue in which odontoblasts are smoothly aligned on the dentin wall. After pulpectomy or enlargement/cleaning of an infected root canal, a root canal filler for non-extracted tooth, which comprises tooth pulp stem cells and an extracellular matrix, is inserted into the apical side of the root canal of the non-extracted tooth. The tooth pulp stem cells may be, for example, dental pulp CXCR4-positive cells. It is preferred to attach, to the crown side of the root canal, migration factor(s) including at least one factor selected from among a cell migration factor, a cell proliferation factor, a neurotrophic factor and an angiogenic factor. | 2012-06-28 |
20120164605 | INTERACTIVE LEARNING SYSTEM AND METHOD THEREOF - An interactive learning system and method is provided. The interactive system includes a camera device and an interactive device. The camera device executes a functional operation, and transforms the functional operation into executive information. Then, the camera device transmits the executive information to the interactive device. The interactive device generates guiding information for guiding a user to operate the camera device according to model information of the camera device, and transmits the guiding information to the camera device so as to control the camera device to execute a guiding operation related to the guiding information. | 2012-06-28 |
20120164606 | APPARATUS AND METHOD FOR PROVIDING STORY MAKING SERVICE - Disclosed is a method for providing a story making service enabling multiple users to modify/change/rewrite contents, the method for providing a story making service includes: recommending and selecting the contents so as to help the users to select the contents performing the story making; determining a group to create or select the group using the story making together for the selected contents; generating and transmitting information necessary to provide services within the selected group; and reconfiguring a story to perform modification/change/rewriting works on the story within the selected contents and the selected service group. | 2012-06-28 |
20120164607 | Application system of multidimensional chinese learning - A multidimensional Chinese learning application system includes a main computer, a data storage device installed in the mainframe computer, and an input device, characterized by said data storage device comprises: a PinYin module including an initial study unit, a single-final study unit, a multiple-final study unit, an overall reading unit and an exercise unit; a character recognizing module including a stroke unit, a stroke order unit, a structure unit, a component unit, an encoding unit and a game unit; a dictionary searching module, including an input unit, an inquiry unit and a display unit. | 2012-06-28 |
20120164608 | METHODS AND SYSTEM FOR VISUALLY REPRESENTING A RATE OF WRITING A PLURALITY OF IDENTICAL CHINESE CHARACTERS FOR AT LEAST ONE USER ON A DISPLAY - There are provided methods and a system for visually representing a rate of writing a plurality of identical Chinese characters for at least one user on a first portion of a display, with the visual representation having both a discrete movement component and a rate of activity component. | 2012-06-28 |
20120164609 | Second Language Acquisition System and Method of Instruction - A system for second language acquisition that trains the user's brain's auditory processing area to recognize phonemes, syllables, and words of a foreign language, by presenting videos of a word or phrase spoken at a slow rate and at a normal rate, and an interface for the user to enter the phonemes, syllables, and words that he or she has heard, with immediate responses indicating correct or incorrect entries. Additionally, said system for second language acquisition teaches simplified vocabulary and grammar; enables users to add additional vocabulary and languages; teaches via auditory, visual, and kinaesthetic (movement) methods; and can be used on small mobile devices such as cellular telephones. | 2012-06-28 |
20120164610 | CHILDREN'S FLASHCARDS SYSTEM eBOOK CLIPBOARD TAB - The present invention relates to a system and method of utilizing flashcards-like clipboards, wet erase pen, die cut alphabet letters and numbers, and magnetic receiver plates having female die cut holes for the die cut letters and numbers, etc. for children to learn while playing games. The clipboard of the present invention is generally rectangular with concave sides and rounded corners. It has many unique features including a wet-erase surface for writing and learning, an integral clip for clipping additional notes, an ID holder for holding identification card. It can also be used for tabbing projection above a sheet of paper and as an aid to help electronic book reading for children and adults with reading challenges. The clipboard is also designed to be accompanied by additional clipboards held together by a book ring that can be worn with a lanyard or put in a pocket as flashcards. | 2012-06-28 |
20120164611 | ENGLISH LEARNING SYSTEM - The present invention relates to an English learning system, and more specifically, to an English syllable pronunciation and spelling learning system for the learning of words (including phrases and sentences), in which a learner sequentially recognizes syllables and spellings at a level of detail which is not the word so that the efficiency of memorization of the pronunciations and spellings of words can be improved, by outputting English words onto a screen under control in such a way that the spellings of the words, or the spellings of the syllables separated from the words, are displayed with a space or visual effect (coloring and writing with spaces) or else a time effect (sequentially outputting to screen) and an auditory effect. | 2012-06-28 |
20120164612 | IDENTIFICATION AND DETECTION OF SPEECH ERRORS IN LANGUAGE INSTRUCTION - Speech errors for a learner of a language (e.g., an English language learner) are identified automatically based on aggregated characteristics of that learner's speech. | 2012-06-28 |
20120164613 | Determining a demographic characteristic based on computational user-health testing of a user interaction with advertiser-specified content - Methods, apparatuses, computer program products, devices and systems are described that carry out specifying at least one of a plurality of user-health test functions responsive to an interaction between a user and at least one advertiser-specified attribute; and transmitting at least one demographic characteristic of the user based on at least one output of the at least one of a plurality of user-health test functions. | 2012-06-28 |
20120164614 | COMPUTER PROGRAM AND METHOD FOR PAIN PREVENTION - A non-transitory computer readable storage medium for instructing the user of an electronic device to perform wellness activities using a processor is provided. The non-transitory computer readable storage medium includes instructions to command the processor to track the user's time at the electronic device. The instructions further command the processor to periodically alert the user to perform a wellness activity. The instructions also command the processor to display the wellness activity for the user to perform. | 2012-06-28 |
20120164615 | TRAINING SYSTEM FOR APPLYING A MEDICAL COMPRESSION PRODUCT, AND A DEVICE AND PROGRAM FOR USE THEREWITH - A system for training a practitioner to apply a medical compression product (“MCP”) may include an artificial limb having a geometry representative of a limb of a patient and a plurality of sensors disposed on the artificial limb. The artificial limb may be adapted for the practitioner to apply an MCP (e.g., a bandage) thereto, and the training system may be configured to provide feedback information to the practitioner regarding the application of the MCP. The feedback information may include quantitative information, such as: numerical values representing the pressure applied by the MCP to the limb at various locations; target pressure values; and numerical differences between the target and applied pressure values. The feedback information may also include qualitative information, such as: color coded pressure maps, and text and/or audio signals. | 2012-06-28 |
20120164616 | Exercise Mode For Small Intestine Endoscope - It is possible to provide a small intestine endoscope training simulator ( | 2012-06-28 |
20120164617 | ADAPTABLE AUDIO INSTRUCTION SYSTEM AND METHOD - An adaptable audio instruction system and method allows for tailoring and modification to audio sequences used for audio instruction of users. The tailoring and modification abilities of the system regard content and presentation details of the audio sequences to comply with user preferences and user progress in learning content contained in the audio sequences. | 2012-06-28 |
20120164618 | MONOTONOUS GAME-LIKE TASK TO PROMOTE EFFORTLESS AUTOMATIC RECOGNITION OF SIGHT WORDS - System and methods are provided to promote effortless automatic recognition of common sight words. A subject performs a game-like task that generates novel non-verbal visual stimuli that triggers visual attention shifts that enhance foveal and parafoveal recognition of non-verbal and verbal stimuli laterally presented in the right or left visual field. The present invention engages a shared motor-perceptual-cognitive neural network involving oculomotor, visuo-motor and selective executive cognitive behaviors on both brain hemispheres. The present invention has applications to a wide range of non-verbal pre-orthographic visual processes and early lexical processes, not only contributing to enabling reading fluency to dyslexics, reluctant and slow readers, but also to beginning readers. The present invention has wide applications in learning disabilities and normative individuals learning to read. | 2012-06-28 |
20120164619 | Educational Assessment System and Associated Methods - A system and method are provided for allowing a member of an audience to interact with a presenter in an organizational environment by accessing network software as a service in a browser or native application software operable with a processor. Such a system and method improves classroom participation and assessing effectiveness of presentation. The system includes software elements that are useable by accessing the cloud network or as may be installable on a local processor and on a communication device, which can comprise a computer, a mobile phone, or a hand held device in general. Presenter and audience member interfaces are provided for composing, posing, and answering questions, participating in a class blog, and receiving real-time data on class comprehension of student learning objectives. | 2012-06-28 |
20120164620 | RECOMMENDING COMPETITIVE LEARNING OBJECTS - A method and apparatus for competitive learning objects in a learning environment is provided. Based on the success that a student has with a particular learning item, a learning recommendation is generated for another student. | 2012-06-28 |
20120164621 | FACILITATING TARGETED INTERACTION IN A NETWORKED LEARNING ENVIRONMENT - A method and apparatus for facilitating interaction in a learning environment is provided. Based on the subject matter that a student is working on, another student is selected for interaction with the student. | 2012-06-28 |
20120164622 | Method for Harvesting and Preparing Porcine Hearts for Use in a Cardiac Surgical Simulator - A method is described and disclosed for harvesting and preparing porcine hearts that may be used, among other things, as an improved analog of the human heart in cardiac simulator systems for training surgical personnel for performing beating heart surgery. | 2012-06-28 |
20120164623 | Laminar Flow Reactor - The present invention describes a laminar flow bioreactor with improved laminar flow lines of fluids. The bioreactor housing defines a chamber adapted to receive a scaffold. An inlet aperture at one end of the chamber is in fluid communication with an outlet aperture at the opposite end of the chamber. A bypass mechanism selectively operable from an open position to a closed position consisting of an iris assembly directs a portion of fluid flowing through the chamber around the scaffold-receiving area. This bioreactor is inserted in a bioreactor system. | 2012-06-28 |
20120164624 | SERS Nanotag Assays - Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate. | 2012-06-28 |
20120164625 | METHODS FOR RAPID IDENTIFICATION OF PATHOGENS IN HUMANS AND ANIMALS - The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples. | 2012-06-28 |
20120164626 | DETECTION OF HIGH GRADE DYSPLASIA IN CERVICAL CELLS - Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture. | 2012-06-28 |
20120164627 | METHODS AND DEVICES FOR MICROFLUIDIC POINT-OF-CARE IMMUNOASSAYS - Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples. | 2012-06-28 |
20120164628 | AFFINITY CAPTURE OF CIRCULATING BIOMARKERS - Methods, devices and systems for capturing biomarkers are provided. In particular, methods, compositions, and systems that utilize affinity capture devices comprising a processing chamber, affinity capture agent and porous membrane are provided. | 2012-06-28 |
20120164629 | Antibodies For Oncogenic Strains Of HPV And Methods Of Their Use - The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided. | 2012-06-28 |
20120164630 | METHODS FOR MAINTAINING THE INTEGRITY AND IDENTIFICATION OF A NUCLEIC ACID TEMPLATE IN A MULTIPLEX SEQUENCING REACTION - The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template. | 2012-06-28 |
20120164631 | APPARATUS AND METHOD FOR PERFORMING NUCLEIC ACID ANALYSIS - The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis. | 2012-06-28 |
20120164632 | QUANTITATION OF CELLULAR DNA AND CELL NUMBERS USING ELEMENT LABELING - Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a fast and accurate analysis of cellular DNA and cell numbers. | 2012-06-28 |
20120164633 | DIGITAL DROPLET SEQUENCING - The present invention provides systems, devices, methods, kits, and compositions for sorting and analysis of nucleic acid sequences using digital droplet PCR. In particular, provided herein are methods to convert complex samples into a plurality of simplified samples, and sequence analysis thereof. | 2012-06-28 |
20120164634 | Method for Separating Particles and/or Cells Having 2 and More Surface Specificities - The invention describes an easy method for the gentle separation of cells and/or particles from liquids, preferably blood. For that purpose known steps of magnetic separation procedures are combined with capture particle-assisted separating methods. | 2012-06-28 |
20120164635 | LARGE STOKE SHIFT NIR DYES - A compound of the following formula: | 2012-06-28 |
20120164636 | MAMMALIAN OOCYTE DEVELOPMENT COMPETENCY GRANULOSA MARKERS AND USES THEREOF - The present invention relates to the competence of oocytes to uterine implantation and development into living individual. The invention more particularly relates to marker that are detected and measured in granulosa cells collected along with the oocytes during oocyte aspiration as it is done in assisted reproduction techniques. | 2012-06-28 |
20120164637 | SUSCEPTIBILITY TO BONE DAMAGE - In one aspect, the present invention provides methods for determining susceptibility to bone damage in a subject. In some embodiments, the methods comprise screening for polymorphisms in the MTHFR and collagen Iα1 genes that are associated with susceptibility to bone damage. In some embodiments, the methods comprise screening for elevated levels of homocysteine in a subject, wherein elevated levels of homocysteine are associated with an increased risk of bone damage. The methods of the invention may be used in predicting the response of a patient to treatment. Also provided are methods for prevention or reducing the risk of bone damage in a subject. | 2012-06-28 |
20120164638 | Digital Quantification of DNA Methylation - Abnormal DNA methylation can be used as a biomarker in cancer patients. For such purposes, it is important to determine precisely the fraction of methylated molecules in an analyzed sample. A technology we term Methyl-BEAMing achieves this goal. Individual bisulfite-treated DNA molecules can be PCR-amplified within aqueous nanocompartments containing beads, resulting in a population of beads each containing thousands of copies of the template molecule. After hybridization with probes specific for methylated sequences, the beads can be analyzed by flow cytometry. This approach enables detection and enumeration of one methylated molecule in a population of ˜5000 unmethylated molecules. Methyl-BEAMing provides digital quantification of rare methylation events and is generally applicable to the assessment of methylated genes in clinical samples. | 2012-06-28 |
20120164639 | METHODS FOR DETECTING LOW GRADE INFLAMMATION - The present invention relates to methods for detecting the presence of low grade inflammation in a patient. | 2012-06-28 |
20120164640 | METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH SUDDEN CARDIAC DEATH RISK - The present invention provides a method of identifying a subject as having an increased risk of sudden cardiac death or cardiac arrhythmia by detecting in the subject the presence of various polymorphisms associated with an increased risk of sudden cardiac death or cardiac arrhythmia. | 2012-06-28 |
20120164641 | Methods and Compositions for Detecting Mutation in the Human Epidermal Growth Factor Receptor Gene - The invention comprises reagents and methods for detecting cancer-causing mutations in the human EGFR gene. Further, a method of detecting the mutations and a method of treatment are disclosed. | 2012-06-28 |
20120164642 | METHODS AND MATERIALS FOR IDENTIFYING NODULAR FASCIITIS - This document provides methods and materials involved in detecting gene rearrangements indicative of nodular fasciitis. For example, methods and materials for determining if a mesenchymal neoplasm is nodular fasciitis based at least in part on the detection of a gene rearrangement (e.g. a USP6 or MYH9 rearrangement) are provided. | 2012-06-28 |
20120164643 | SET OF OLIGONUCLEOTIDE PROBES AS WELL AS METHODS AND USES THERETO - The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and a method of generating the set of oligonucleotide probes. Further, the present disclosure relates to a kit comprising the set of oligonucleotide probes and at least one further component. | 2012-06-28 |
20120164644 | NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES - This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease. | 2012-06-28 |
20120164645 | MULTIPLEX AMPLIFICATION AND DETECTION - The invention relates to the field of multiplex amplification. In particular, the invention relates to methods for assaying a sample for one or more nucleic acid targets in a single reaction based on the distinct melting temperatures or melting profiles of primers and/or probes. The invention also provides probes and kits for use in such methods. | 2012-06-28 |
20120164646 | DETECTION OF GENETIC ABNORMALITIES - The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells. | 2012-06-28 |
20120164647 | METHODS FOR ASSESSING THE SUSCEPTIBILITY OF A HUMAN TO DIMINISHED HEALTH AND WELLNESS - The present invention relates to methods for assessing the advisability that a human should employ a compensatory composition comprised of one or more antioxidant ingredients. The methods involve assessing occurrence in the human's genome of a plurality of certain polymorphisms. Methods for determining the composition of preferred compensatory compositions are also disclosed. | 2012-06-28 |
20120164648 | Integrated Versatile and Systems Preparation of Specimens - The invention of Integrated Versatile and Systems Preparation of Specimens relates an open module technology which integrates synchronously the methods of protection, isolation and alteration of specimens into the “One for All” product or kit. The product or kit comprises a core module without or with Plug-in modules and a set of comprehensive protocols which can simultaneously or individually isolate systems biomolecules including DNA/ccfDNA, Large RNA/mRNA/ccfRNA, Small RNA/miRNA/ccfmiRNA, Protein, Lipid, Carbohydrates, and Metabolite versatilely from a vast variety of specimens including solid specimens and liquid specimens. The product or kit can accept new and custom Plug-in modules to expand functions and applications. The product or kit prepares specimens and biomolecules with features and benefits of high quality, easy, fast, no toxicity, safe to user and environment, low demanding, cost-effective, reducing waste, saving nature resources and protecting environment, and leads to a low-carbon and Green economy in preparation of specimens. | 2012-06-28 |
20120164649 | SYSTEM, DEVICES AND METHODS FOR MONITORING AND DETECTION OF CHEMICAL REACTIONS - Systems, devices and methods are described herein that are configured for use in the monitoring and detecting of chemical reactions, such as, for example, the monitoring and detection of Polymerase chain reactions (PCR). For example, the systems and devices described herein can be used for accelerated real-time PCR. A fully integrated PCR system is provided that includes a touch screen user interface, eliminating the need for additional computers, keyboards, and related devices. The PCR systems described herein can be network enabled to provide communications between one or more PCR monitoring and detection devices and a central monitoring station. A disposable sample holding device can be placed in the PCR device for testing in an upright vertical orientation, providing improved optical scanning capabilities and rapid heating and cooling capabilities. | 2012-06-28 |
20120164650 | METHOD AND MEANS TO MODULATE PROGRAMMED CELL DEATH IN EUKARYOTIC CELLS - The invention provides for the use of isolated polynucleotides encoding maize poly (ADP-ribose) polymerase (PARP) proteins to produce eukaryotic cells and organisms, particularly plant cells and plants, with modified programmed cell death. Eukaryotic cells and organisms particularly plant cells and plants, are provided wherein either in at least part of the cells, preferably selected cells, the programmed cell death (PCD) is provoked, or wherein, on the contrary, PCD of the cells or of at least part of the cells in an organism is inhibited, by modulation of the level or activity or PARP proteins in those cells. | 2012-06-28 |
20120164651 | METHODS AND COMPOSITIONS FOR DETECTION OF SMALL RNAS - Currently, the circularization of small RNAs is broadly regarded as an obstacle in ligation-related assays and explicitly avoided while short lengths of linear RNA targets is broadly recognized as a factor limiting use of conventional primers in PCR-related assays. In contrast, the disclosed invention capitalizes on circularization of small RNA targets or their conjugates with oligonucleotide adapters. The circular RNA templates provide amplification of the target sequences via synthesis of multimer nucleic acids that can be either labeled for direct detection or subjected to PCR amplification and detection. Structure of small circular RNAs and corresponding multimeric nucleic acids provide certain advantages over current methods including flexibility in design of conventional RT and PCR primers as well as use of 5′-overlapping dimer-primers for efficient and sequence-specific amplification of short target sequences. Our invention also reduces number of steps and reagents while increasing sensitivity and accuracy of detection of small RNAs with both 2′OH and 2′-OMe at their 3′ ends. Our invention increase sensitivity and specificity of detection of microRNAs and other small RNAs with both 2′OH and 2′-OMe at their 3′ ends while allowing us to distinguish these two forms from each other. | 2012-06-28 |
20120164652 | QUANTITATING HIGH TITER SAMPLES BY DIGITAL PCR - The present invention provides systems, devices, methods, kits, and compositions for nucleic acid analysis using digital PCR. In particular, methods are provided to analyze high titer samples that cannot be divided into a sufficient number of partitions containing zero nucleic acid molecules per partition to allow for Poisson analysis (digital PCR analysis). | 2012-06-28 |
20120164653 | METHODS FOR THE DIAGNOSIS OF MULTIPLE SCLEROSIS BASED ON ITS MICRORNA EXPRESSION PROFILING - The invention relates, in general, to a method for the diagnosis of multiple sclerosis based on determining amounts of one or more micro-RNAs correlated with multiple sclerosis in a biological sample from a subject. | 2012-06-28 |
20120164654 | COMPOSITION FOR REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION - A composition for a reverse transcription polymerase chain reaction, which comprises a thermostable DNA polymerase, a reverse transcriptase, a dye marker and a specific gravity-increasing agent; and a premix reagent for a one-step RT-PCR, which comprises the composition, is not frozen under usual storage conditions at −20 to −30° C. and has excellent handleability. | 2012-06-28 |
20120164655 | HEAT FLOW POLYMERASE CHAIN REACTION SYSTEMS AND METHODS - Methods and systems for polymerase chain reactions (PCR) that are capable of detecting amplified DNA during or after the PCR process. The methods and systems may utilize DSC or DTA analysis techniques. | 2012-06-28 |
20120164656 | Methods To Identify Compounds Useful For The Treatment Of Proliferative And Differentiative Disorders - The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases, and transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting subunits. The present invention relates to screening assays that use novel and known substrate-targeting subunits of ubiquitin ligases to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel and known ubiquitin ligases which modulate activity of the novel and known ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative and differentiative disorders. | 2012-06-28 |
20120164657 | Method of detecting botulinum neurotoxin and antibodies that neutralize botulinum neurotoxin action - A highly sensitive method of analyzing a sample for the presence or activity of botulinum neurotoxin (BoNT) or antibodies specific for botulinum neurotoxin is disclosed. In one embodiment, the method comprises the steps of preparing primary non-human mammalian or avian spinal cord cells, and exposing the cells to a test sample, in parallel with a control sample, and examining the extent of cleavage of the intracellular neuronal target protein in both the test and control sample. | 2012-06-28 |
20120164658 | Transcription Factor Modulator - The present invention relates to novel agents that are useful for modulating transcription factor activity. In particular, the present invention relates to a transcription factor modulator comprising (i) a pharmaceutically-effective amount of a HLS-5 polypeptide, isoform thereof, functional fragment thereof or pharmaceutical composition thereof or (ii) a compound or composition capable of regulating the endogenous levels of HLS-5 or its activity; or (iii) combinations thereof. | 2012-06-28 |
20120164659 | HUMAN HCV-INTERACTING PROTEINS AND METHODS OF USE - The present invention generally relates to a method for identifying and cloning nucleic acid molecules encoding a new class of proteins or fragments thereof, capable of interacting with proteins associated with the Human Hepatitis C virus (HCV) and thus being suitable either alone or in complex with the HCV protein for serving as a target for the development of antiviral drugs. In this context, the present invention provides novel HCV-interacting proteins and complexes as well as antibodies which specifically recognize and bind to the complex or to specific domains of HCV proteins. | 2012-06-28 |
20120164660 | METHOD FOR USING A DIAGNOSTIC AGENT WHICH INCLUDES A CALCIUM BINDING PROTEIN ASSAY REAGENT AND ASSAY METHOD FOR CALCIUM BINDING PROTEIN - A bovine- or human-derived calcium-binding protein with a prescribed amino acid sequence, a method for its production, and antibodies against the protein and uses thereof. | 2012-06-28 |
20120164661 | METHODS AND REAGENTS FOR SIGNAL AMPLIFICATION - The present invention provides reagents containing binding moieties conjugated to dextran moieties, methods of making such reagents, and use of such reagents in a variety of molecular and cellular assays. | 2012-06-28 |
20120164662 | TEST METHOD ON RENAL DISEASES - Provided is a test method for the assessment of the necessity of renal biopsy in a subject to be tested, who is suspected of having a renal disease. Specifically provided are a test method for a renal disease, including using urinary podocalyxin and one or more additional markers in combination, and a test reagent for use in the test method and a test reagent kit for use in the test method. The present invention allows the discrimination of a poor prognosis group even for poor prognosis cases with no overt findings in a conventional test method, and thus allows the assessment of a renal disease, the assessment of the necessity of renal biopsy, prognostic prediction, and the like to be performed exactly. | 2012-06-28 |
20120164663 | Methylated Arginine Metabolites as Risk Predictors of Cardiovascular Disease - Methods for using methylated arginine metabolites and the arginine methylation index as markers for cardiovascular disease are described: The methods typically include determining the levels of dimethylarginine and N-monomethylarginine in a biological sample, comparing the levels of dimethylarginine and N-monomethylarginine to obtain an arginine methylation index; comparing the arginine methylation index to one or more control values; and using this comparison to characterize the subject's risk of having or developing cardiovascular disease or various complications associated therewith. | 2012-06-28 |
20120164664 | T1R TASTE RECEPTORS AND GENES ENCODING SAME - Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed. | 2012-06-28 |
20120164665 | Interleukin-1 Alpha Antibodies and Methods of Use - Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors. | 2012-06-28 |
20120164666 | Glycoprotein Vesicles and Their Methods of Use - Provided are methods of collecting, detecting and altering cells and molecular entities using glycoprotein micelles and vesicles. Glycoprotein vesicles comprising a glycoprotein micelle, at least a monolayer of lectin and/or a monolayer of biologically active glycoproteins are also provided. The invention further provides methods of detecting protein glycosylation using the vesicles of the invention. | 2012-06-28 |
20120164667 | METHOD FOR TEST ON DIABETIC NEPHROPATHY - Provided is a test method for the detection of diabetic nephropathy at an early stage as compared to a conventional method. Specifically provided are: a test method for diabetic nephropathy, including detecting urinary podocalyxin; the test method, further including assessing diabetic nephropathy at least Stage I; a test reagent for use in the test method; and a test reagent kit for use in the test method. The present invention is based on a finding that urinary podocalyxin reflects the development and condition of diabetic nephropathy with high sensitivity at an early stage as compared to urinary albumin. | 2012-06-28 |
20120164668 | ULTRASOUND ASSISTED IMMUNOASSAY - The invention relates to methods, devices and systems for an enhanced, ultrasound assisted immunoassay (such as a Western blot immunoassay). In particular, there are provided methods, devices and system for the automated and enhanced processing of a membrane having proteins associated therewith, wherein the processing includes the use of ultrasonic energy. | 2012-06-28 |
20120164669 | MARKER PANEL FOR LEFT VENTRICULAR HYPERTROPHY - The present disclosure relates to methods, compositions, kits and devices for diagnosing, distinguishing and/or facilitating a therapeutic decision in a subject having left ventricular hypertrophy. In some aspects, the methods, compositions, kits and devices disclosed herein allow for diagnosing, distinguishing and/or facilitating a therapeutic decision in a subject having physiological left ventricular hypertrophy, and/or for a subject suffering from pathological left ventricular hypertrophy. | 2012-06-28 |
20120164670 | METHODS AND KITS FOR MEASURING ENZYME ACTIVITY - The invention relates to methods and kits for measuring enzyme activity, including enzymes that produce nicotinamide. | 2012-06-28 |
20120164671 | METHODS FOR MONITORING IMMUNOSUPPRESSANT DRUG LEVELS, RENAL FUNCTION, AND HEPATIC FUNCTION USING SMALL VOLUME SAMPLES - Systems and methods are provided for monitoring a immunosuppressant drug level and renal function, hepatic function, or a combination thereof in a patient, comprising obtaining a small volume blood sample from the patient; determining the level of at least one immunosuppressant drug in the small volume blood sample and determining the level of a second immunosuppressant drug or analyzing the renal function, the hepatic function, or a combination thereof in the patient. In some embodiments, the immunosuppressant drug levels are determined using a liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure. Also provided are kits for use in any of the systems and methods described herein. | 2012-06-28 |
20120164672 | HIGH-THROUGHPUT IN VITRO TRANSLATION (CELL-LYSATE BASED) ASSAY FOR DETECTING QUORUM SENSING SIGNALS - A cell-lysate extract based assay reagent for detecting quorum sensing signals is generally provided, along with methods of making and using the same. The assay reagent generally includes a cell-lysate extract formed from a biosensor bacterium (e.g., | 2012-06-28 |
20120164673 | PTP1B INHIBITORS - Described herein are agents, including antibodies, antibody fragments, polypeptides and organic small molecules, that bind reversibly inactive PTP1B (designated herein in the alternative as PTP1B-SN or PTP1B-OX) and stabilize it (stabilize PTP1B-OX) in such a manner that they inhibit reactivation of reversibly oxidized, inactive PTP1B by reduction (by reducing agent) and have no substantial direct inhibitory effect on phosphatase activity/PTP1B activity (for example, as detectable in assays in vitro). | 2012-06-28 |
20120164674 | DEVICES AND WASHES FOR BIOMARKER STABILIZATION - Herein are disclosed compositions, washes, rinses, devices, systems and methods for biomarker stabilization, in part in bodily fluids, as well as methods and formulations for improving the sampling and testing of fluids for biomarkers. Included in the disclosure are exemplary embodiments of rinses or washes containing a stabilizing agent to prevent the destruction of a diagnostic agent or biomarker and exemplary systems for the detection of diagnostic biomarkers in a bodily fluid | 2012-06-28 |
20120164675 | METHODS AND KIT FOR PROTEASE ENZYME ASSAYS - A method for testing efficacy of a protease enzyme assay, the method comprising providing an enzyme which acts as a surrogate enzyme control for the protease enzyme; combining the surrogate enzyme control with an assay substrate for the protease enzyme; and determining a change in the assay substrate resulting from the surrogate enzyme control acting on the assay substrate; wherein the protease enzyme is selected from the group consisting of metalloproteinases, serine proteases, and cysteine proteases; a method for conducting a protease enzyme assay using the method for testing efficacy; a kit including an enzyme which acts as a surrogate enzyme control for a protease enzyme in testing efficacy of a protease enzyme assay; and a method of releasing the kit are provided. | 2012-06-28 |
20120164676 | USE OF DIAZOLIDINYL UREA FOR ANTI-CLUMPING OF BIOLOGICAL SAMPLES - The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices. | 2012-06-28 |
20120164677 | METHOD AND APPARATUS FOR VIABLE AND NONVIABLE PROKARYOTIC AND EUKARYOTIC CELL QUANTITATION - A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating cells such as the standard plate count, the methylene blue method and the slide viability technique. The method is particularly useful in several applications such as: a) quantitating bacteria in milk, yogurt, cheese, meat and other foods, b) quantitating yeast cells in brewing, fermentation and bread making, c) quantitating mammalian cells in research, food and clinical settings. The method is especially useful when both total and viable cell counts are required such as in the brewing industry. The method can also be employed to determine the metabolic activity of cells in a sample. The apparatus, device, and/or system used for cell quantitation is also disclosed. | 2012-06-28 |
20120164678 | MICROBIAL PRODUCTION OF NATURAL SWEETENERS, DITERPENOID STEVIOL GLYCOSIDES - The invention relates to recombinant expression of a steviol or steviol glycosides biosynthetic pathway enzymes in cells and the production of steviol or steviol glycosides. | 2012-06-28 |
20120164679 | BIOLOGICAL MICROFLUIDICS CHIP AND RELATED METHODS - A biological microfluidics chip ( | 2012-06-28 |
20120164680 | Asynchronous Magnetic Bead Rotation Sensing Systems and Methods - Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also described herein are methods for controlling the illumination and imaging of rotating magnetic particles. | 2012-06-28 |
20120164681 | Method for Detection or Identification of Bacteria or Bacterial Spores - A method and apparatus for detecting bacteria and bacterial spores are disclosed in which a sample is assessed for the presence of bacteria and/or bacterial spores by reference to horizontally polarized fluorescent light. | 2012-06-28 |
20120164682 | METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING - A method for analyzing a blood sample residing within an analysis chamber, which sample has one or more first and second constituents, which constituents are different from one another. The method includes the steps of: a) imaging the sample containing the first and second constituents, which sample is mixed with a colorant that causes the first and second constituents to fluoresce upon exposure to light, and which colorant is also operative to absorb light, the imaging produces image signals representative of fluorescent emissions from the sample and optical density of the sample; b) determining one or more values representative of fluorescent emission from the first and second constituents; c) determining one or more values representative of optical density for the first and second constituents; and d) distinguishing the first constituents from the second constituents using the fluorescent emission representative values and the optical density representative values. | 2012-06-28 |
20120164683 | BUFFY COAT SEPARATOR FLOAT SYSTEM AND METHOD - A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers. | 2012-06-28 |
20120164684 | SAMPLE MEASURING APPARATUS AND SAMPLE MEASURING METHOD - A sample measuring apparatus of measuring a component in a biological sample, comprising: an input section for inputting a sample species of a biological sample; a measurement sample preparation section for preparing a measurement sample by mixing the biological sample with a reagent; a first measurement section; a second measurement section being different from the first measurement section; a measurement sample supply section for supplying the measurement sample prepared in the measurement sample preparation section to at least one of the first measurement section and second measurement section; and a control section for controlling the measurement sample supply section based on the inputted sample species. | 2012-06-28 |
20120164685 | POLYPEPTIDES AND IMMUNIZING COMPOSITIONS CONTAINING GRAM POSITIVE POLYPEPTIDES AND METHODS OF USE - The present invention provides isolated polypeptides isolatable from a | 2012-06-28 |
20120164686 | YEAST PROMOTERS - The invention relates to recombinant promoters and expression constructs comprising the promoters that may be used to express a protein of interest in yeast, such as | 2012-06-28 |