26th week of 2015 patent applcation highlights part 28 |
Patent application number | Title | Published |
20150175999 | STABILIZED LACCASE ENZYME AND METHODS OF MAKING AND USING THE SAME - Provided herein are compositions and methods for enhancing enzyme activity, half-life, thermostability, enhanced activity at elevated temperature, and/or decreasing the pH dependency of laccase enzyme. Also provided are methods for using the composition comprising the stabilized enzymes. | 2015-06-25 |
20150176000 | STABILIZED TRANSGLUTAMINASE AND PROCESS FOR PRODUCTION THEREOF - Disclosed is a transglutaminase having excellent stability. Also disclosed is a process for producing the transglutaminase. Specifically disclosed is a stabilized transglutaminase, which has such a structure in which a pro-sequence peptide of transglutaminase is bound to a mature transglutaminase. Also specifically disclosed is a process for producing stabilized transglutaminase, which includes the steps of: culturing a microorganism capable of producing transglutaminase under the conditions where transglutaminase can be produced; and separating and collecting matured transglutaminase having a pro-sequence peptide bound thereto from a culture medium. | 2015-06-25 |
20150176001 | ACOUSTOPHORETIC SEPARATION TECHNOLOGY USING MULTI-DIMENSIONAL STANDING WAVES - A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor. | 2015-06-25 |
20150176002 | Human Lambda Light Chain Mice - Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided. | 2015-06-25 |
20150176003 | EUGLOBULIN-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF DEFIBROTIDE - It is disclosed a method for determining the biological activity of defibrotide, which comprises the steps of: a) bringing into contact defibrotide, mammalian euglobulin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product; and b) measuring the amount of product formed at successive times, to thereby determine the biological activity of the defibrotide. Liquid defibrotide formulations are also disclosed, preferably water solutions, having a defined biological activity and, in particular, having an activity of 25 to 35 IU/mg of defibrotide, preferably from 27.5 to 32.5 IU/mg and, more preferably, from 28 to 32 IU/mg. | 2015-06-25 |
20150176004 | IN VITRO MEMBRANE PROTEIN MOLECULAR EVOLUTIONARY ENGINEERING TECHNIQUE - The objective of the present invention is to improve the efficiency of screening/selection of a membrane protein in molecular evolutionary engineering (for example, an enzyme evolutionary method). | 2015-06-25 |
20150176005 | MODULATION OF ENHANCER RNA MEDIATED GENE EXPRESSION - Disclosed herein are methods and compounds for inhibiting gene expression by inhibiting enhancer RNAs (eRNAs). Such methods and compounds are useful for reducing expression of certain genes, many of which are associated with a variety of diseases and disorders. | 2015-06-25 |
20150176006 | NUCLEIC ACIDS FOR DOWN-REGULATION OF GENE EXPRESSION - Recombinant nucleic acid molecules are provided that form hair pin structures and can be used to down-regulate gene expression. For example, a nucleic acid molecule can comprise a flanking and lower stem loop sequence from a mir-16 gene; an antisense target sequence; a mir-30 loop sequence; a complement of the anti-sense target sequence; and a lower stem loop complementary to the mir-16 sequence. Methods for down regulating gene expression in a cell using such recombinant nucleic acid molecules are also provided. | 2015-06-25 |
20150176007 | COMPOSITIONS AND METHODS FOR MODULATING HBV EXPRESSION - Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine. | 2015-06-25 |
20150176008 | Methods of inducing insulin production - The present invention provides a method of inducing insulin production in a cell by up-regulating a target gene involved in insulin production in said cell using an saRNA (short activating ribonucleic acid) which specifically down-regulates a target antisense RNA transcript present in said cell, wherein
| 2015-06-25 |
20150176009 | RNAPII-140 NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 2015-06-25 |
20150176010 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS - The invention relates to Histamine type 4 receptor (H4R) inhibitors for treating tinnitus. | 2015-06-25 |
20150176011 | METHODS OF IDENTIFYING AND TREATING GLIOBLASTOMA - The invention encompasses methods and kits used in the detection of invasive glioblastoma based upon the expression of NHERF-1. The methods and kits also allow prediction of disease outcome as well as therapeutic outcome. | 2015-06-25 |
20150176012 | Protein with recombinase activity for site-specific DNA-recombination - The invention relates to the use of a protein with recombinase activity to catalyze a site-specific DNA recombination and a method for producing a site-specific DNA recombination. The invention is applicable alone or in combination with other recombinase systems for genetic manipulation, for example in medical research. The objective of the invention is solved by the use of a protein with recombinase activity to catalyze a site-specific DNA recombination at, preferably at two, recognition sites that are identical or reverse complementary to each other. The invention also includes a method for producing a site-specific DNA recombination comprising the steps of a) providing a cell comprising at least two recognition sites that are identical or reverse complementary to each other; and b) contacting a protein with recombinase activity with the recognition sites, thereby producing the site-specific DNA-recombination. | 2015-06-25 |
20150176013 | THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS - Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells. | 2015-06-25 |
20150176014 | SUGAR TRANSPORT SEQUENCES, YEAST STRAINS HAVING IMPROVED SUGAR UPTAKE, AND METHODS OF USE - Disclosed are nucleic acid constructs comprising coding sequences operably linked to a promoter not natively associated with the coding sequence. The coding sequences encode | 2015-06-25 |
20150176015 | HIGH-THROUGHPUT DNA FRAGMENT ASSEMBLY - This invention is related to methods and systems for vector assembly for transgenic plants. A uniform modular process is used to reduce cycle time and the methods and systems provided herein can increase cloning throughput using multiple-well plates, for example 96-well plates. In some embodiments, the methods and systems provided herein eliminate or reduce the need for sequencing confirmation because no PCR is involved in the vector assembly process. | 2015-06-25 |
20150176016 | METHOD FOR MODIFYING LIGNIN BIOSYNTHESIS IN PLANTS - The disclosure is based on the discovery of genes which influence lignin biosynthesis. In particular, the inventors have observed that if the expression, function and/or activity of these gene(s) (or any protein products thereof) is/are modulated, the lignin content of plants can be altered. As such, this disclosure provides plants, which exhibit modulated expression of one or more lipase/esterase/thioesterase family gene(s) and which may find application in methods for producing biofuels. | 2015-06-25 |
20150176017 | VEGETABLE OILS AND USES THEREFOR - The specification relates to plants and their seeds and oil obtained therefrom, and to methods of producing same comprising oil having modified fatty acid compositions, such that 28% to 80% of the total fatty acid content in the seedoil is palmitic acid, 0% to 16% is palmitoleic acid, 0% to 4% is C16:2 fatty acid, 3% to 33% is stearic acid, 1% to 40% is oleic acid, 4% to 50% is linoleic acid and 0% to 10% is linolenic acid. The specification describes nucleic acid molecules encoding RNA capable of conferring these properties, in particular, RNA that inhibits expression of an oil biosynthesis gene encoding KASII in seeds of a plant. Genetic constructs and cells comprising the nucleic acid molecules are also described and claimed. | 2015-06-25 |
20150176018 | Novel ETO1 genes and use of same for reduced ethylene and improved stress tolerance in plants - The invention provides isolated ethylene over-producer 1 (ETO1) nucleic acid molecules which are associated with ethylene production in plants and their encoded proteins. The present invention provides methods and compositions relating to altering ethylene production and abiotic stress response in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants and antibody compositions. | 2015-06-25 |
20150176019 | Over-expression of GCN2-Type Protein Kinase in Plants - Methods and compositions to achieve a significant reduction in free amino acid concentration in plants and a mitigation of the effects of sulphur deficiency by over-expression of GCN2. | 2015-06-25 |
20150176020 | MAMMALIAN-TYPE GLYCOSYLATION IN PLANTS BY EXPRESSION OF NON-MAMMALIAN GLYCOSYLTRANSFERASES - The present invention relates to non-mammalian β-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian β-1,4-galactosyltransferases and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian β-1,4-galactosyltransferases. | 2015-06-25 |
20150176021 | USE OF CAD GENES TO INCREASE NITROGEN USE EFFICIENCY AND LOW NITROGEN TOLERANCE TO A PLANT - Provided are methods of increasing nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence encoding a polypeptide at least 80% identical to SEQ ID NO: 2560, 2557, 184, 238, 188, 154-156, 158-161, 163-183, 185-187, 189-197, 200-237, 239-264, 266-269, 1351, 1365-1425, 1429-1457, 1459, 1461-1730, 1735, 1739-2397, 2533-2541, 2544-2556, 2558, 2559, 2561-2562 or 2563. Also provided are isolated polynucleotides and polypeptides which can be used to increase nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant of a plant. | 2015-06-25 |
20150176022 | HERBICIDE-RESISTANT SUNFLOWER PLANTS, POLYNUCLEOTIDES ENCODING HERBICIDE=RESISTANT ACETO HYDROXY ACID SYNTHASE LARGE SUBUNIT PROTEINS, AND METHODS OF USE - Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (AHASL) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described. Methods of using the polynucleotides to enhance the resistance of plants to herbicides, and methods for controlling weeds in the vicinity of herbicide-resistant plants are also described. | 2015-06-25 |
20150176023 | TRANSGENIC PLANTS EXPRESSING A pH-SENSITIVE NITRATE TRANSPORTER - The invention relates to transgenic plants with improved growth and nitrogen use efficiency expressing nitrate transporter gene, methods of making such plants and methods for improving growth and nitrogen use efficiency. | 2015-06-25 |
20150176024 | TARGET GENES FOR CONTROL OF PLANT PARASITIC NEMATODES AND USE OF SAME - The invention relates to identifying and evaluating target coding and non-coding sequences for control of plant parasitic nematodes by inhibiting one or more biological functions, and their use. The invention provides methods and compositions for identification of such sequences and for the control of a plant-parasitic nematode population. By feeding one or more recombinant double-stranded RNA molecules provided by the invention to the nematode, a reduction in disease may be obtained through suppression of nematode gene expression. The invention is also directed to methods for making transgenic plants that express the double-stranded RNA molecules, and the plant cells and plants obtained thereby. | 2015-06-25 |
20150176025 | RAS OPPOSITE (ROP) AND RELATED NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN AND/OR HEMIPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran and/or hemipteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran and/or hemipteran pests. The disclosure also concerns methods for making that express nucleic acid molecules useful for the control of coleopteran and/or hemipteran pests, and the plant cells and plants obtained thereby. | 2015-06-25 |
20150176026 | REPLICATION COMPETENT PSEUDO-TYPE RETROVIRUS VECTOR SYSTEM - The present invention provides a vector system in which a MuLV-Gag gene, a MuLV-Pol gene, and a GaLV-Env gene are expressed in two separate vectors. The vector system is capable of inserting a therapeutic gene to these two separate vectors, and in this raged, the size of an inserted gene is not limited and a variety of foreign therapeutic genes may be inserted to the vectors. Accordingly, the foreign therapeutic gene may be delivered in a safe and efficient manner to desired tissue of cells of aberrant proliferation. Therefore, the vector system is applicable in a composition for delivering a gene targeting the aberrantly dividing cells of aberrant proliferation, wherein the composition includes a retrovirus produced by cell line transfection. The vector system is also applicable in a composition for preventing or treating a disease caused by cells of aberrant proliferation of, such as cancer cells. | 2015-06-25 |
20150176027 | ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR - Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. | 2015-06-25 |
20150176028 | XYLOSE FERMENTING YEAST CONSTRUCTED USING A MODIFIED GENOME SHUFFLING METHOD - Disclosed is a method of providing a recombinant microorganism. The method comprises the steps of: (a) providing a hybrid microorganism comprising DNA from a host microorganism and a donor microorganism; and (b) fusing DNA extracted from a second microorganism into the hybrid microorganism to form the recombinant microorganism. Also disclosed are recombinant yeasts produced by the method of the present disclosure and a method of fermenting sugar using the recombinant yeast produced by the method of the present disclosure. | 2015-06-25 |
20150176029 | METHOD FOR PRODUCING BETA-SANTALENE - The present invention provides a method of producing β-santalene, said method comprising contacting at least one polypeptide with farnesyl pyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce β-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing β-santalene is also an object of the present invention. | 2015-06-25 |
20150176030 | PRODUCTION OF METHANE - This invention relates to a method for producing hydrocarbons from carbon dioxide and water in the presence of hydrogen and methanogen/s. the methanogen/s is/are provided in an aqueous growth substrate and the aqueous growth substrate is pressurized to a pressure of from 5 to 1000 bar with a pressurizing fluid containing or comprising carbon dioxide. In an embodiment of the invention, a cathode is provided to generate hydrogen and also to control the pH of the aqueous growth substrate. The invention also relates to an apparatus for carrying out the method. | 2015-06-25 |
20150176031 | METHOD FOR DIGESTING A BIOMASS COMPRISING LIGNIN TOGETHER WITH CELLULOSE AND/OR HEMICELLULOSE - The invention relates to a method for digesting a biomass comprising, lignin, cellulose, and hemicellulose, comprising the steps of: (a) contacting the biomass with a first solvent for dissolving the cellulose and/or the hemicellulose, (b) contacting the dissolved cellulose and/or hemicellulose with a precipitant for forming a precipitate comprising cellulose and/or hemicellulose and residual lignin, wherein the precipitant is selected from the group consisting of alkanes, ethers, and esters; and (c) contacting the precipitate with a second solvent for removing residual lignin from the precipitate. The invention further relates to an apparatus for performing such a method. | 2015-06-25 |
20150176032 | Yeast strains engineered to produce ethanol from acetic acid and glycerol - The present invention relates to processes for producing ethanol from lignocellulosic hydrolysates comprising hexoses, pentoses and acetic acid, whereby genetically modified yeast cells are use that comprise an exogenous gene encoding an acetaldehyde dehydrogenase and a bacterial gene encoding an enzyme with NAD | 2015-06-25 |
20150176033 | REACTIVE OXYGEN SPECIES-RESISTANT MICROORGANISMS - The present disclosure identifies pathways and mechanisms to confer resistance to reactive oxygen species, e.g., hydrogen peroxide, to photoautotrophic organisms. The use of such organisms in host cell culture systems with high levels of reactive oxygen species, such as host cell culture systems decontaminated with hydrogen peroxide, is contemplated. | 2015-06-25 |
20150176034 | METHOD FOR VISCOSITY REDUCTION IN CO-FERMENTATION ETHANOL PROCESSES - The present disclosure provides methods and compositions for reducing the viscosity of biomass process streams in an ethanol production process. The method comprises adding cellulase enzymes to a biomass feedstock that is fermented to produce ethanol, generating whole stillage and thin stillage streams from the post-fermentation biomass, and adding an additional enzyme or enzyme cocktail that reduces the viscosity of the whole stillage stream, thin stillage stream, concentrated thin stillage stream, and/or the syrup stream generated by evaporating the thin stillage. | 2015-06-25 |
20150176035 | TWO-STAGE CONTINUOUS PROCESS FOR PRODUCING A SOLVENT - The present invention relates to a two stage continuous microbiological process for the production of solvents such as acetone, butanol and ethanol. Preferably, the process involves the use of a solventogenic bacteria such as clostridia. In the first (acidogenic) stage, the culture vessel is fed with fresh growth media at dilution rates that support fast growth and acid production. The culture flows into the second (solventogenic) stage, which is a separate culture vessel or vessels, designed to provide the culture with sufficient residence time to convert acids into solvents. Preferably this vessel is tubular or a series of linked batch vessels. | 2015-06-25 |
20150176036 | Genetically Engineered Torulopsis glabrata with Enhanced Extracellular Secretion of Pyruvic Acid - The present invention provides a genetically engineered | 2015-06-25 |
20150176037 | OXIDOREDUCTASE REACTION CONTROL AND USE THEREOF - The present invention is intended to prove a technique useful for controlling the reaction of oxidoreductase, and to provide a reaction system allowing efficient conversion from carbon dioxide to formic acid, and an efficient methanol production system including the reaction system. The reverse redox reaction is selectively promoted by carrying out the reaction catalyzed by an oxidoreductase using an artificial electron carrier. The reaction system is used for the production of methanol. | 2015-06-25 |
20150176038 | Yeast Cells Having NADP(H)-Dependent Reductive TCA Pathway from Pyruvate to Succinate - Recombinant yeast cells contain a reductive TCA pathway from phosphoenolpyruvate or pyruvate to succinate. At least one metabolic step in the pathway includes a reaction of NADPH to produce NADP+. The yeast cell contains at least one exogenous NADPH-dependent gene in the pathway from phosphoenolpyruvate or pyruvate to succinate, preferably an NADPH-dependent malate dehydrogensase or fumarate reducase gene (or both). | 2015-06-25 |
20150176039 | EXPRESSION CONSTRUCT FOR SENSING CELL DENSITY AND SUBSTRATE AVAILABILITY AND ITS USE IN CONVERSION OF HYDROXYCINNAMIC ACIDS - An Expression system; isolated nucleic acid molecule or host cell comprising: (i) A first gene encoding for a first enzyme linked to a first promoter, wherein the first promoter is a time delay promoter; (ii) A second gene encoding for a second enzyme capable of using the product generated by the first enzyme as a substrate, wherein the second gene is operably linked to a second promoter, wherein the second promoter is inducible by the product generated by the first enzyme; (iii) Optionally, a third gene encoding a transcription factor that represses expression of the second gene in the absence of the product generated by the first enzyme, wherein the third gene is operably linked to a third promoter that regulates expression of the third gene; and its use in producing a product such as hydroxybenzaldehyde. | 2015-06-25 |
20150176040 | PRODUCTION OF FATTY ALCOHOLS FROM ENGINEERED MICROORGANISMS - Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a β-ketoacyl acyl carrier protein synthase. | 2015-06-25 |
20150176041 | METHODS FOR PRODUCING DICARBOXYLIC ACIDS - The present invention provides methods of producing dicarboxylic acids. The methods involve incubating a fatty acid or hydrocarbon substrate with an enzyme to produce a dicarboxylic acid product. The enzyme acts on the substrate to produce a product that has been both over-oxidized and has undergone cleavage of a C—C bond. In some embodiments the enzymes having these useful characteristics are mutants of a cytochrome P450 enzyme, for example an enzyme of the class CYP102 or a mutant thereof. The invention provides enzymes where these desirable characteristics can be found in a single enzyme, and thus in some embodiments the methods can be performed through the action of a single enzyme. | 2015-06-25 |
20150176042 | METHODS OF RECOVERING OIL FROM MICROORGANISMS - Provided herein are methods of recovering oil from microorganisms. The methods are useful, for example, in obtaining nutritional oils and/or lipid biofuels. The methods of recovering oil described herein include contacting a population of microorganisms with one or more enzymes under conditions that cause disruption of the microorganisms, concentrating the disrupted microorganisms, and extracting lipids from the disrupted microorganisms at high temperature in the presence of a salt and in the absence of solvent. | 2015-06-25 |
20150176043 | Processes of Treating Cellulosic Material - The invention relates to processes of producing sugars and/or fermentation products from pretreated cellulosic material comprising the steps of: preconditioning pretreated cellulosic material; hydrolyzing using a cellulolytic enzyme preparation; and fermenting sugars with a microorganism; wherein a solid-liquid separation step, resulting in a solid fraction and a liquid fraction, is carried out: after preconditioning, but before hydrolysis; or after hydrolysis, but before fermentation; wherein phenol oxidizing enzyme and hemicellulase are present or added during preconditioning; after preconditioning, but before hydrolysis; or during hydrolysis. | 2015-06-25 |
20150176044 | Production of Fucosylated Glycoproteins - Described herein are compositions including filamentous fungal cells, such as | 2015-06-25 |
20150176045 | Method for in Vivo Production of Deglycosylated Recombinant Proteins Used as Substrate for Downstream Protein Glycoremodeling - The present invention includes compositions and methods of reducing the glycosylation of proteins comprising: obtaining a cell that expresses one or more proteins that comprise one or more glycosylation sites and are glycosylated; expressing in the cell one or more glycosidases that cleaves one or more glycosyl groups from the one or more proteins; and isolating the one or more proteins with reduced glycosylation from the cell. | 2015-06-25 |
20150176046 | Method for Automated Unloading of Microbial Detection Apparatus - The present invention is directed to a method and automated unloading means for unloading a container from an apparatus. The apparatus of the present invention may include a means for automated loading, a means for automated transfer and/or a means for automated unloading of a container (e.g., a specimen container). In one embodiment, the apparatus can be an automated detection apparatus for rapid non-invasive detection of a microbial agent in a test sample. The detection system also including a heated enclosure, a holding means or rack, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system. | 2015-06-25 |
20150176047 | CUSHIONING DEVICE INSPECTION SYSTEM, A SAMPLING DEVICE FOR INSPECTION OF A CUSHIONING DEVICE AND A CUSHIONING DEVICE INSPECTION METHOD - The invention provides a system for checking the interior of hermetically sealed cushioning devices for contamination, comprising a hermetically sealed cushioning device ( | 2015-06-25 |
20150176048 | METHOD FOR ISOLATING MICROORGANISMS ON A CULTURE MEDIUM, AND RELATED DEVICE - Method for isolating microorganism from a sample likely contaminated by microorganism, including: (a) device for isolating microorganisms including a bottom waterproof layer, a nutritional layer, which is placed on the bottom layer and includes a dehydrated culture medium, an isolation layer which is pervious to elements included in the nutritional layer and is capable of retaining the bacteria on the surface and covering all or part of the nutritional layer, and a top protective layer; (b) depositing a volume of the sample on the isolation layer; (c) isolating the microorganisms by impoverishing or layering the sample using an isolating device; (d) incubating the device for an amount of time at a temperature to enable growth of microorganisms, method including at least one step of rehydrating the culture medium using a volume of liquid before or with step b) and/or c) and/or d), before or simultaneously with step b) and/or c). | 2015-06-25 |
20150176049 | DETERMINING USABILITY OF ANALYTICAL TEST STRIP - A system for determining usability of an analytical test strip includes a sample chamber to receive a fluid sample, a reagent in the sample chamber having a moisture-varying impedance, and two detection electrodes contacting the reagent. A test meter applies an AC waveform across the reagent via the detection electrodes while measuring an impedance of the reagent. A processor automatically determines whether the measured impedance of the reagent meets a dryness criterion. The meter includes a housing, a strip port connector, an impedance measurement circuit and the processor. A method for determining usability of a strip inserted in a hand held meter includes applying an AC waveform across a reagent of the strip and measuring a first electrical signal, and determining whether the strip meets the dryness criterion based on the first electrical signal. The test strip and ways of determining an analyte are also described. | 2015-06-25 |
20150176050 | DRY CHEMISTRY, LATERAL FLOW-RECONSTITUTED CHROMATOGRAPHIC ENZYME-DRIVEN ASSAYS - A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are either absent from the intended sample or insufficiently present therein to permit completion of the desired reaction, are predeposited as substrate in dry form together with ingredients necessary to produce a desired color upon occurrence of the desired reaction. The strip is equipped with a sample pad placed ahead of the substrate deposit in the flowstream, to which liquid sample is applied. The sample flows from the sample pad into the substrate zone where it immediately reconstitutes the dried ingredients while also intimately mixing with them and reacting with them at the fluid front. The fluid front moves rapidly into the final “read zone” wherein the color developed is read against predetermined color standards for the desired reaction. Pretreatment pads for the sample, as needed, (e.g. a lysing pad for lysing red blood cells in whole blood) are placed in front of the sample pad in the flow path as appropriate. The assay in the format of the invention is faster and easier to perform than analogous wet chemistry assays. | 2015-06-25 |
20150176051 | Resonance Energy Transfer Assay with Cleavage Sequence and Spacer - A molecular construct comprises a donor label, an acceptor label, a linker peptide disposed between the donor and the acceptor, the linker having a cleavage site sequence, and a flexible peptide spacer between at least one of (a) the donor and the cleavage site sequence and (b) the acceptor and the cleavage site sequence. The cleavage site sequence is a protease cleavage site, and the flexible spacer peptide is positioned and dimensioned to facilitate an electronic hop between the donor and acceptor label. | 2015-06-25 |
20150176052 | Method for Identifying Bacteria from the Bacillus Cereus Group - The present invention relates to the field of microbiological testing of food. It relates to a method for identifying bacteria of the | 2015-06-25 |
20150176053 | TEST STRIP INSERTION DRIVE MECHANISM FOR ANALYTE METER - An analyte meter having a test strip port includes a detector proximate the port for detecting a test strip being inserted therein. A drive mechanism connected to the detector is configured to engage and pull a detected test strip into the test meter and into electrical and mechanical engagement therewith to enable analyte tests to be conducted. | 2015-06-25 |
20150176054 | Determining Analyte Concentration From Variant Concentration Distribution In Measurable Species - A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay. | 2015-06-25 |
20150176055 | METHOD AND APPARATUS TO MINIMIZE DIAGNOSTIC AND OTHER ERRORS DUE TO TRANSPOSITION OF BIOLOGICAL SPECIMENS AMONG SUBJECTS - A method and apparatus for minimizing diagnostic errors due to transposition of biological specimens among subjects provides for independent biometric confirmation that a given specimen is from a given donor. In certain embodiments, a biological specimen confirmation kit comprises a portable and openable case housing components of the kit, at least one biological specimen container adapted to receive a biological testing specimen from a donor, and at least one reference sample device adapted to receive a biological reference specimen from the same donor, such that the testing and reference specimens can later be compared for donor match verification by a reference verification entity. | 2015-06-25 |
20150176056 | ELECTROSPUN FIBERS FOR PROTEIN STABLIZIATION AND STORAGE - An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods. In one implementation, the fibers can be produced in a continuous manner and dissolve rapidly. | 2015-06-25 |
20150176057 | METHODS AND APPARATUS FOR SEQUENTIAL AMPLIFICATION REACTIONS - The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample. | 2015-06-25 |
20150176058 | DEVICE FOR PREPARING A SAMPLE - The invention provides a device for preparing a fluid sample, including but not limited to a sample comprising genomic DNA. | 2015-06-25 |
20150176059 | OLIGONUCLEOTIDE INHIBITOR OF DNA POLYMERASES - The invention comprises a reversible oligonucleotide inhibitor of nucleic acid polymerases. Methods of designing said inhibitors and using said inhibitors in amplification and detection of nucleic acid, particularly detection of RNA by RT-PCR are also disclosed. | 2015-06-25 |
20150176060 | Method For Coding Of Multiple PCR Reactions For Assay Recognition - The present invention provides for methods and compositions that use fluorescent dyes for the identification of reagents and solutions that are used to perform PCR assays. | 2015-06-25 |
20150176061 | METHOD FOR SCREENING REAGENTS USED IN PCR ASSAYS - The present invention relates to methods for screening of reagents used in the performance of polymerase chain reaction (PCR) assays. The invention has applications for genotyping, pathogen detection and in vitro diagnostics. | 2015-06-25 |
20150176062 | METHOD FOR PROVIDING DNA FRAGMENTS DERIVED FROM AN ARCHIVED SAMPLE - Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc.). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, and are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable. | 2015-06-25 |
20150176063 | REMOVAL OF PCR INHIBITORS - Provided herein is technology relating to processing and preparing samples and particularly, but not exclusively, to methods, systems, and kits for removing assay inhibitors, e.g., compounds that inhibit polymerase chain reaction, from samples comprising nucleic acids. In particular, the technology is directed toward treating crude sample preparations, such as supernatants from homogenized stool samples, with insoluble polyvinylpyrrolidone (PVP) to form PVP-assay inhibitor complexes, and filtration to separate the PVP-assay inhibitor complexes from the crude sample preparations to produce clarified samples that exhibit reduced assay inhibition. | 2015-06-25 |
20150176064 | Method for Detecting and Identifying Enterohemorrhagic Escherichia coli - The invention relates to methods for predicting whether a sample contains enterohemorrhagic | 2015-06-25 |
20150176065 | DETECTION OF PNA CLAMPING - This invention provides methods and systems for detecting sequence variants in a sample nucleic acid. Methods include PNA clamping/PCR using primers with binding moieties followed by capture and detection of amplicons on a solid support. Systems include PCR reagents with primers having binding moieties, a PNA clamping probe, a solid support capable of capturing the PCR amplicons incorporating the binding moieties, and a detector device. | 2015-06-25 |
20150176066 | Inspection Tool for Nucleic Acid Chromatography - An inspection tool for nucleic acid chromatography includes an elongated porous sheet and a backing member. The porous sheet has a surface including a detection surface that has a strip-shaped indication portion where a nucleic acid probe for capturing the target nucleic acid is fixed. The backing member has an attached surface in a concave shape. The porous sheet has a warped shape following the concave shape of the attached surface. | 2015-06-25 |
20150176067 | MICROARRAY SYSTEM WITH IMPROVED SEQUENCE SPECIFICITY - The invention provides a novel array method for nucleic acid sequence detection with improved specificity which allows for detection of genetic variation, from simple SNPs (where the variation occurs at a fixed position and is of limited allelic number) to more complex sequence variation patterns (such as with multigene families or multiple genetic strains of an organism where the sequence variation between the individual members is neither fixed nor consistent). The array is comprised of short, synthetic oligonucleotide probes attached to a solid surface which are hybridized to single-stranded targets. Single stranded targets can be produced using a method that employs primers modified on the 5′ end to prohibit degradation by a 5′-exonuclease that is introduced to degrade the unprotected strand. The invention further provides for printing buffers/solutions for the immobilization of oligonucleotide probes to an array surface. The invention also provides hybridization and wash buffers and conditions to maximize hybridization specificity and signal intensity, and reduce hybridization times. | 2015-06-25 |
20150176068 | METHODS OF ISOTHERMAL AMPLIFICATION USING BLOCKED PRIMERS - Methods for rapidly detecting clinically relevant mutations in the infectious genome of an agent are disclosed. The methods include use of a novel target and temperature dependent RNase H mediated cleavage of blocked DNA primers to initiate isothermal helicase-dependent amplification of a target sequence such as a sequence in the the rpoB gene. | 2015-06-25 |
20150176069 | METHOD FOR DETECTING METHYLATED CYTOSINE BY USING BISULFITE REACTION - The invention provides a method for converting non-methylated cytosine in a single-stranded DNA into uracil by a bisulfite reaction with a high conversion efficiency from non-methylated cytosine into uracil. The invention also provides a method for amplifying the single-stranded DNA in which non-methylated cytosine has been converted into uracil, as well as a method for detecting methylated cytosine in the single-stranded DNA. | 2015-06-25 |
20150176070 | FLOW CELL FOR BIOMATERIAL ANALYSIS AND BIOMATERIAL ANALYSIS DEVICE - In a biomaterial analysis, erroneous detection of a particle emitting fluorescence is prevented, and highly sensitive and highly accurate optical detection in biomaterial analysis is performed. A flow cell ( | 2015-06-25 |
20150176071 | PRESERVING GENOMIC CONNECTIVITY INFORMATION IN FRAGMENTED GENOMIC DNA SAMPLES - A method of sequencing a target nucleic acid polymer by (a) modifying a target nucleic acid polymer to produce a modified nucleic acid polymer; (b) producing fragments of the modified nucleic acid polymer, wherein the fragments are attached to locations on a solid support surface (c) determining nucleotide sequences from the fragments at the locations; and (d) producing a representation of the nucleotide sequence for the target nucleic acid polymer based on the nucleotide sequences from the fragments and the relative distances between the locations on the solid support surface. | 2015-06-25 |
20150176072 | MOLECULAR MALIGNANCY IN MELANOCYTIC LESIONS - Disclosed are methods for determining whether a melanocyte-containing sample (such as a nevus or other pigmented lesion) is benign or a primary melanoma. These methods can include detecting (at the molecular level, e.g., mRNA, miRNA, or protein) the expression of at least two disclosed genes in a biological sample obtained from a subject. Also provided are arrays and kits that can be used with the methods. | 2015-06-25 |
20150176073 | USE OF MICROVESICLES IN DIAGNOSIS, PROGNOSIS, AND TREATMENT OF MEDICAL DISEASES AND CONDITIONS - The invention provides a novel method for detecting the presence or absence of one or more transfer RNAs (tRNAs) contained in microvesicles from a subject. The invention also provides a novel method for detecting the presence or absence of one or more human endogenous retrovirus elements (HERV) in microvesicles from a subject. The methods disclosed is directed to aiding diagnosis, prognosis, minotring and evaluation of a disease or other medical condition in a subject. | 2015-06-25 |
20150176074 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING - The present invention relates generally to 3′-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide. | 2015-06-25 |
20150176075 | MULTIPLEXED NUCLEIC ACID TARGET IDENTIFICATION BY STRUCUTRE BASED PROBE CLEAVAGE - The present invention provides for novel methods and compositions for nucleic acid sequence detection. Unique, identifying cleavage fragments from probes, bound to target nucleic acids, are produced during PCR by the 5′-nuclease activity of the polymerase. The identity of the targets can be determined by identifying the unique cleavage fragments. | 2015-06-25 |
20150176076 | HISTONE DEACETYLASE 6 (HDAC6) BIOMARKERS IN MULTIPLE MYELOMA - The invention relates to histone deacetylase (HDAC) biomarkers in multiple myeloma. Specifically, the biomarkers are drug specific, histone deacetylase (HDAC) or HDAC6 biomarker RNAs for multiple myeloma. The invention also relates to a kit for determining the treatment efficiency of a HDAC6 inhibitor, and a kit for identifying a histone deacetylase 6 (HDAC6) inhibitor. The invention further relates to a method for monitoring treatment efficiency of an HDAC inhibitor in a subject. | 2015-06-25 |
20150176077 | METHODS FOR PREDICTING WHETHER A SUBJECT IS AT RISK OF DEVELOPING A FOLLICULAR LYMPHOMA - The present invention relates to a method for determining whether a subject is at risk of developing a FL comprising the steps consisting of i) determining the t(14:18) frequency in a blood sample obtained from the subject, ii) comparing the t(14:18) frequency determined at step i) with a predetermined reference value and iii) concluding that the subject has very high probability to develop a FL when the t(14:18) frequency determined at step i) is higher than the predetermined reference value. | 2015-06-25 |
20150176078 | PROSTATE CANCER GENE EXPRESSION PROFILES - The present disclosure provides gene expression profiles that are associated with prostate cancer. The gene expression profiles can be used to detect prostate cancer cells in a sample and to distinguish between well differentiated (WD) prostate cancer and poorly differentiated (PD) prostate cancer. Also provided is an array comprising oligonucleotide probes for detecting the unique gene signature associated with WD and/or PD prostate cancer. | 2015-06-25 |
20150176079 | MARKERS FOR CANCER - The present invention relates to novel markers for hypermethylation of gene promoters in cancers. In particular the present invention relates to a method of determining whether a tumour is developing in the aero-digestive system, or whether a subject is relapsing after treatment of such a tumour. The method comprises determining the methylation level, the number of methylated CpG sites or the methylation state of CpG sites in a nucleic acid sequence in the promoter region, first exon or intron, of one or more genes selected from the group consisting of CNRIP1, MAL, FBN1, SPG20, SNCA, and INA. The method further relates to a diagnostic kit for detecting tumours in the aero-digestive tract. | 2015-06-25 |
20150176080 | METHOD OF HEPATOCELLULAR CARNINOMA CLASSIFICATION AND PROGNOSIS - Methodology for the in vitro classification and/or prognosis of hepatocellular carcinoma (HCC) from a HCC sample is based on the determination of the expression profile of particular gene combinations. For example, in one embodiment, a method comprises measuring the expression level in an HCC sample of at least 8 genes selected from the group consisting of: RAB1A, REG3A, NRAS, RAMP3, MERTK, PIR, EPHA1, LAMA3, G0S2, HN1, PAK2, AFP, CYP2C9, CDH2, HAMP, SAE1, ADH6, DCN, FLJ10159, ALDH1L1, IGF1, LECT2, SLC38A1, SPARCL1, CTNNA2, GLUL, LEF1, MATN2, MME, PFN2, SPINT2, TBX3, and FGFR2; b) calculating 6 subgroup distances from the expression profile; and c) classifying the HCC tumor in the subgroup for which the subgroup distance is the lowest, wherein the 6 subgroups G1, G2, G3, G4, G5, and G6 are defined by the presence (+) or absence (−) of their clinical and genetic features. | 2015-06-25 |
20150176081 | METHOD TO DETERMINE RESPONSIVENESS OF CANCER TO EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING TREATMENTS - Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 2015-06-25 |
20150176082 | PLASMA MICRORNAS FOR THE DETECTION OF EARLY COLORECTAL CANCER - The present invention relates in general to the field of colorectal cancer detection, and more particularly, to plasma microRNAs for the detection of early colorectal cancer. Specifically, the present invention includes methods, kits and biomarkers for diagnosing or detecting colorectal neoplasia in a human subject comprising the steps of: A method for diagnosing or detecting colorectal neoplasia in a human subject comprising the steps of: obtaining one or more biological samples from the subject suspected of suffering from colorectal neoplasia; measuring an overall expression pattern or level of one or more microRNAs obtained from the one or more biological samples of the subject; and comparing the overall expression pattern of the one or more microRNAs from the biological sample of the subject suspected of suffering from colorectal neoplasia with the overall expression pattern of the one or more microRNAs from a biological sample of a normal subject, wherein the normal subject is a healthy subject not suffering from colorectal neoplasia, wherein overexpression of a combination of miR19a and miR19b, or miR19a and miR19b and miR15b is indicative of colorectal cancer. | 2015-06-25 |
20150176083 | PRIMERS FOR DETECTING PLASMODIUM - The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific | 2015-06-25 |
20150176084 | CANDIDA ALBICANS OLIGONUCLEOTIDES, DETECTION METHOD, AND KIT THEREOF - The invention discloses an in vitro method for the identification of | 2015-06-25 |
20150176085 | CANDIDA PARAPSILOSIS OLIGONUCLEOTIDES, DETECTION METHOD, AND KIT THEREOF - The invention discloses an in vitro method for the identification of | 2015-06-25 |
20150176086 | PNA Probes, Probe Sets, Methods and Kits Pertaining to the Detection of Candida - This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of | 2015-06-25 |
20150176087 | METHODS AND COMPOSITIONS FOR IDENTIFYING YEAST - The invention relates to a method of identifying a specific yeast species in patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the yeast species from the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically identify the yeast species, and specifically identifying the yeast species. The invention also relates to a method of identifying a yeast mycotoxin in patient tissue or body fluid. The method comprises the steps of extracting and recovering the yeast mycotoxin from the patient tissue or body fluid, contacting the yeast mycotoxin with an antibody directed against the yeast mycotoxin, and identifying the yeast myocotoxin. Both of these methods can be used to determine if a patient is at risk for or has developed a disease state related to a yeast infection, and to develop an effective treatment regimen for the patient. | 2015-06-25 |
20150176088 | ASSAY FOR IDENTIFYING COMPOUNDS WHICH AFFECT STABILITY OF MRNA - The present invention relates to an assay for the identification of biological active compounds, in particular to a reporter gene assay for the identification of compounds, which have an effect on mRNA stability. More particularly, the present invention relates to a reporter gene expression system and cell lines comprising said expression system. The invention further relates to compounds which destabilise mRNA. | 2015-06-25 |
20150176089 | METHODS AND COMPOSITIONS FOR IDENTIFYING JC VIRUS - The disclosure relates to methods and compositions for detecting the presence of Prototype and/or Archetype JC virus in a biological sample from a subject. In some embodiments, the methods include amplifying and detecting a first nucleic acid sequence unique to Archetype JC virus in a biological sample, and a second nucleic acid sequence common to both Archetype and Prototype JC virus in the biological sample. In several embodiments, the methods can be used to identify JC virus in a biological sample from a subject at risk for progressive multifocal leukoencephalopathy. Compositions and kits for use in the disclosed methods are also provided. | 2015-06-25 |
20150176090 | BIOMASS PRE-TREATMENT FOR CO-PRODUCTION OF HIGH-CONCENTRATION C5- AND C6-CARBOHYDRATES AND THEIR DERIVATIVES - Described is a method of processing biomass to separate it into a liquid fraction enriched in solubilized C5-sugar-containing oligomers and C-5 sugar monomers and a solid fraction enriched in substantially insoluble cellulose and C6-sugar-containing oligomers. The method includes the steps of reacting biomass with a solvent system comprising water, at least one lactone, or at least one furan, or at least one cyclic ether, and at least one acid, for a time and at a temperature to yield the liquid and solid fractions. The liquid and solid fractions may then be separated. Gamma-valeroloactone is a preferred lactone for use in the solvent system. Tetrahydrofuran is a preferred furan species for use in the solvent system. | 2015-06-25 |
20150176091 | SUPERCRITICAL HYDROLYSIS OF BIOMASS - Methods are disclosed for processing biomass by single-stage supercritical hydrolysis, wherein the biomass has been size reduced. | 2015-06-25 |
20150176092 | METHODS AND SYSTEMS FOR PROCESSING A REACTION PRODUCT MIXTURE OF CELLULOSIC BIOMASS MATERIAL - Processing of a reaction product mixture containing at least one volatile organic compound as well as lignin, lignin derived compounds, and/or unextracted cellulose and hemicellulose using a recovery system comprising at least two flashers or at least one flasher and at least two reboilers. In a particular embodiment, the reaction product mixture comes from reactions involving deconstruction (or digestion) of biomass, particularly cellulosic biomass which contains various polysaccharides (e.g., carbohydrates) and lignin. | 2015-06-25 |
20150176093 | METHODS AND SYSTEMS FOR PROCESSING A REACTION PRODUCT MIXTURE OF CELLULOSIC BIOMASS MATERIAL - Processing of a reaction product mixture of cellulosic biomass material containing at least one volatile organic compound at least one of lignin, a lignin-derived compound, unextracted cellulose, unextracted hemicellulose, a caramelan, and any combination thereof by vaporizing the at least one volatile organic compound using at least thermal energy generated by combusting at least a portion of the reaction product mixture. In a particular embodiment, the reaction product mixture comes from reactions involving deconstruction (or digestion) of cellulosic biomass which contains various polysaccharides (e.g., carbohydrates) and lignin. | 2015-06-25 |
20150176094 | Tannery Process With Effluent Recycling - A recycling process for achieving near-zero emissions of tannery effluent is characterized in that effluent recycling is carried out independently in soaking, liming, re-liming, de-liming bating, pickling chrome tanning, re-tanning, neutralizing, and dyeing procedures. The effluents in the above procedures can be recycled in each step. This process greatly reduces effluent discharge and helps solve the problem of tanning pollution. The process also improves the quality of the finished leather, effectively decreases loose grain rate and increases compactness and fullness of the finished product. The project can reduce chemical material consumption by 15%-55%. For example, the consumption of chromium powder can be reduced up to 65%. Consumption of other chemical materials can be reduced by more than 90%, while certain chemical materials can be essentially completely conserved. | 2015-06-25 |
20150176095 | SHAFT FURNACE AND METHOD OF OPERATING SAME - A method of operating a shaft furnace includes inserting a mixture including anthracite coal and coke into a cavity defined by the furnace, and disposing a metal feedstock within the cavity. The method includes injecting natural gas at a natural gas flow rate and a first quantity of oxygen gas at a first oxygen gas flow rate into the cavity simultaneously through at least one burner. The method also includes driving a second quantity of oxygen gas at a supersonic oxygen gas flow rate into the cavity through at least one lance, wherein the supersonic oxygen gas flow rate is greater than the first oxygen gas flow rate. The method also includes combusting the mixture within the cavity to produce a stack gas, melting the metal feedstock to produce a melted metal material, and monitoring the stack gas to thereby operate the shaft furnace. A shaft furnace is also disclosed. | 2015-06-25 |
20150176096 | METHOD FOR PRODUCING PIG IRON, AND BLAST FURNACE TO BE USED THEREFOR - A blast furnace ( | 2015-06-25 |
20150176097 | MOLTEN METAL TREATMENT LANCE - A molten metal treatment lance includes a refractory having at least one channel extending through the refractory. A first tubular member having two open ends is located in the channel of the refractory. The first tubular member has a side wall having an inner surface and an outer surface. A second tubular member having an open end and a closed end is positioned in the first tubular member. The second tubular member has a side wall having an inner surface, an outer surface and at least one opening extending from the inner surface of the side wall of the second tubular member to the outer surface of the side wall of the second tubular member. The second tubular member is positioned in the first tubular member so as to form a space between the inner surface of the side wall of the first tubular member and the outer surface of the side wall of the second tubular member. | 2015-06-25 |
20150176098 | FURNACE FOR HEATING METAL GOODS - The invention pertains to a furnace for heating metal goods. | 2015-06-25 |