25th week of 2011 patent applcation highlights part 56 |
Patent application number | Title | Published |
20110151476 | METHOD OF DETECTION AND/OR TITRATION IN VITRO OF AN UNCONVENTIONAL TRANSMISSIBLE AGENT - The invention relates to an in vitro method for the in vitro detection and/or titration of a non-conventional transmissible agent (NCTA) or of a protein of pathological conformation, which is a marker for infectiousness related to the NCTA, in a sample, comprising: replication or propagation, in cells in culture, of the NCTA present in the sample, and then repeated incubation with a substrate which allows amplification of the NCTA or of the protein of pathological conformation, nonpathological conformer of the NCTA, before determination of the presence and/or of the amount of the NCTA or of the protein of pathological conformation in the sample. | 2011-06-23 |
20110151477 | METHODS FOR DETECTING ANTIBODIES IN MUCOSAL SAMPLES AND DEVICE FOR SAMPLING MUCOSAL MATERIAL - A method to detect local antibodies such as antigen-specific IgE via a brush biopsy specimen of a mucosal surface of a subject is disclosed. The method is easily performed in an office setting on both adult and pediatric patients. Also disclosed is a brush device specially designed for harvesting materials from a mucosal surface such as the medial surface of the inferior turbinate. | 2011-06-23 |
20110151478 | TRANSCRIPTIONAL BIOMARKERS AND METHODS FOR DETECTING AND ISOLATING CANCER CELLS IN BODY FLUIDS AND TISSUE SPECIMENS - The invention provides molecules that target cancer-specific transcription complexes (CSTC), compositions and kits comprising CSTC-targeting molecules, and methods of using CSTC-targeting molecules for the treatment, detection and monitoring of cancer. | 2011-06-23 |
20110151479 | MICROFLUIDIC SYSTEMS INCORPORATING FLOW-THROUGH MEMBRANES - Disclosed is a flow-through membrane assay that takes advantage of a high surface area and rapid transport while allowing individual control over flow rates and times for each step of a multi-step assay. A microfluidic card features channels in communication with a porous membrane, channels on either side of membrane to allow transverse flow across the membrane, capturing a labeled target from the sample by flowing the sample across the membrane, or capturing a target from the sample followed by flowing a reagent containing a label that binds to the target. Fluid can be pushed or pulled through the assay membrane by external control. Air near the membrane is managed by diverting air between fluids to a channel upstream of the assay membrane, venting air between fluids through a hydrophobic membrane upstream of the assay membrane, and/or by venting trapped air through a hydrophobic membrane downstream of the assay membrane. | 2011-06-23 |
20110151480 | METHODS OF PURIFYING ZSIG33 - The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included. | 2011-06-23 |
20110151481 | BETA-2 MICROGLOBULIN AS A BIOMARKER FOR PERIPHERAL ARTERY DISEASE - The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject. | 2011-06-23 |
20110151482 | AUTOMATED DEVELOPER FOR IMMUNO-STAINED BIOLOGICAL SAMPLES - Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time. | 2011-06-23 |
20110151483 | Mammalian Sweet and Amino Acid Heterodimeric Taste Receptors Comprising T1R3 and T1R1 - The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors. | 2011-06-23 |
20110151484 | hERG MUTANTS AND USES THEREOF - An isolated nucleic acid molecule capable of expressing an human ether-à-go-go related gene (hERG) mutant that enhances hERG inactivation, wherein the mutation is not located in the vicinity of the drug-binding pocket within the cavity of the ion conduction pore of the hERG protein. Use of the isolated nucleic acid molecule in an assay for screening potential drug binding to hERG protein. | 2011-06-23 |
20110151485 | METHOD FOR SCREENING FOR ANTIANGIOGENIC AGENT, AND METHOD FOR SCREENING FOR ANTIANGIOGENIC SIGNAL GENE - Disclosed are a method for screening for an antiangiogenic agent and a method for screening for an antiangiogenic gene, both of which are achieved by detecting an antiangiogenic signal within a short time by a simple means. The method for screening for an antiangiogenic agent comprises: a candidate compound administration step of administering a candidate compound for the antiangiogenic agent to a vascular endothelial cell or a cultured cell derived from a vascular endothelial cell; a cell-maintaining step of maintaining the vascular endothelial cell or the cultured cell derived from the vascular endothelial cell to which the candidate compound has been administered; and a signal detection step of detecting the phosphorylation of a protein phosphorylated by the administration of endostatin. | 2011-06-23 |
20110151486 | METHODS AND SYSTEMS TO PREVENT GAS BUBBLES FROM INTERFERING WITH FLOW OF FLUID THROUGH A MEMBRANE REGION - Methods and systems to remove gas bubbles from liquids and to improve uniform fluid flow through a region of a membrane in a microfluidic device, including to reduce, remove, and/or prevent gas bubbles on a surface of a porous membrane. An example membrane bubble trap system may include a fluid channel connected to a bubble pathway that surrounds an opening sealed with a membrane. The bubble pathway may be configured to collect bubbles in fluid that passes through the membrane through buoyancy forces and through a directional feature of a curved surface placed above the membrane. | 2011-06-23 |
20110151487 | Compositions And Methods For The Treatment Of Cancer - Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention discloses inhibitors of the Fanconi anemia pathway and methods using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the treatment of cancer. | 2011-06-23 |
20110151488 | DETECTION AND MONITORING OF LIVER DAMAGE - A method of detecting liver damage in a subject comprises measuring the level of caspase-3 generated cytokeratin-18 fragments in the bodily sample. The level of measuring the level of caspase-3 generated cytokeratin-18 fragments is then correlated with liver disease progression. | 2011-06-23 |
20110151489 | MONITORING SKIN METABOLISM PRODUCTS FOR EVALUATING BURN INJURY - The present invention relates to methods and kits for evaluating the severity of a burn injury, which are based on the detection in a clinical fluid sample of skin metabolism products, such as collagen peptides which are released upon collagen degradation or synthesis. | 2011-06-23 |
20110151490 | Compositions for the Detection and Treatment of Colorectal Cancer - The invention provides methods of identifying proteins and polypeptides and their cognate polynucleotides that are expressed by cells under one environmental condition and not under a second environmental condition. The invention also provides compositions for the treatment and detection of cancer, including colorectal cancer. | 2011-06-23 |
20110151491 | Portable Coagulation Monitoring Device and Method of Assessing Coagulation Response - A device, system and method is disclosed in which small volume blood samples are subjected to shear forces and shear stresses between two parallel planar surfaces to which linear motion trajectories are imparted. The formation of clots or coagulation of the sample is measured from dynamic mechanical coupling which occurs between the two parallel planar surfaces. Detection of the coagulation response can be achieved through optical probing or by measurement of physical effects of the blood sample binding to the planar surfaces, and restricting movement thereof. | 2011-06-23 |
20110151492 | METHOD OF DETECTING ARTICULAR CARTILAGE DEGENERATION OR DAMAGE - An object of the present invention is to provide a detection method capable of detecting articular cartilage degeneration or damage in which the abnormality cannot be detected in a radiograph in a simple method and with high accuracy, a method of evaluating the rate of progression of articular cartilage degeneration or damage, and the like. | 2011-06-23 |
20110151493 | POLYPEPTIDE DISULFIDE BOND ANALYSIS - The present invention relates in part to methods for determining bonding patterns in disulfide-linked peptides containing closely-spaced cysteine residues. Through N-terminal sequencing chemistry coupled with facile liquid chromatography and mass spectrometric analysis of the cleavage products, one can assign connectivity to specific cysteine pairs. A particular advantage of this method is maintenance of disulfide integrity during the process. | 2011-06-23 |
20110151494 | METHODS AND MATERIALS FOR MONITORING MYELOMA USING QUANTITATIVE MASS SPECTROMETRY - The subject invention concerns methods and materials for diagnosing, monitoring the progress, and/or providing a prognosis for multiple myeloma and other conditions associated with antibody production in a person or animal. The methods o f the invention utilize mass spectrometry for quantitative monitoring and detection of antibody produced by the plasma cells. The methods of the invention can be utilized for diagnosis, monitoring, and/or prognosis of multiple myeloma, monoclonal gammopathy, and other immunological or hematological conditions and disorders. In addition to detecting and quantifying antibody in a sample, other biological markers, such as serum albumin and/or beta-2-microglobulin, can also be detected and quantified using the present invention, and in combination with detection and quantification of antibody. Thus, in one embodiment, both antibody and serum albumin and/or beta-2-microglobulin are detected and quantified using mass spectrometry and a diagnosis or prognosis made based on the results and levels detected. | 2011-06-23 |
20110151495 | Method and menstrum for detecting the presence or absence of methicillin resistant staphylococcus aureus (MRSA) in a test sample - A dry mixture, a liquid menstrum, and a method, are described for use in detecting the presence or absence of Methicillin Resistant | 2011-06-23 |
20110151496 | METHODS FOR IDENTIFYING BACTERIAL STRAINS THAT PRODUCE L-TYROSINE - The invention relates to high-throughput screens for identifying bacterial strains capable of L-tyrosine production. | 2011-06-23 |
20110151497 | METABOLOMIC PROFILING OF PROSTATE CANCER - The present invention relates to cancer markers. In particular, the present invention provides metabolites and panels of metabolites that are differentially present in cancer (e.g., prostate or breast cancer). | 2011-06-23 |
20110151498 | APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING - The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel. | 2011-06-23 |
20110151499 | APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING - The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel. | 2011-06-23 |
20110151500 | Blood-Platelet Test Method and Blood-Platelet Test Device - A method for testing platelet function, wherein platelet function is tested by allowing anticoagulated blood, to which a weak platelet-activating reagent has been mixed, to pass through a capillary having a platelet-adhesive surface on at least a part of its inner surface, and observing or measuring the behavior of the blood in the capillary. | 2011-06-23 |
20110151501 | MODULAR SYSTEM AND METHOD FOR DETECTING MICROORGANISMS - A modular automated system ( | 2011-06-23 |
20110151502 | METHOD FOR PERFORMING A BLOOD COUNT AND DETERMINING THE MORPHOLOGY OF A BLOOD SMEAR - A method for counting blood cells in a sample of whole blood. The method comprises the steps of:
| 2011-06-23 |
20110151503 | DEVICE AND METHOD FOR BACTERIOLOGICAL TESTING ON PLASMA - Apparatus for making a bacteriological test on plasma, comprising a sedimentation unit for a blood sample contained in a first container to separate the corpuscular part of the sample, which sediments on the bottom of the first container, from the liquid part or plasma, pick-up and inoculum means to pick up a portion of the surnatant, and to inoculate the portion in a culture ground inside a second container allowing a bacterial growth, optical measurement means, to effect measurements of the culture ground in order to determine the presence of bacteria and microorganisms, and processing means comprising a data bank, to collect measurement data, to construct a curve that represents the intensity of the radiation diverted by the culture ground in the measurement with respect to time, whose parameters are compared with reference values in order to determine typical analysis parameters, said values being characteristic for each bacterial species. Disclosed is further a corresponding method. | 2011-06-23 |
20110151504 | Methods and Systems for Efficient Automatic Slide Staining in Immunohistochemistry Sample Processing - Automated sample processing systems may include onboard efficient high-speed mixing of at least two components with an automatic vertical force fluidic turbulent component mixer of which a mixed component may be aspirated and high-speed dispensed in a mixing vial. Other aspects may include single sweep applying a multi-treatment cleaning cycle to at least one slide. A multi-treatment cleaning cycle may include a washing treatment and a drying treatment. In yet other aspects the present invention may include an automated recovery sample processing system with the capability of detecting at least one immediate condition of a fortuitously terminated automatic sample processing run and perhaps even an automatic terminated sample processing run reconstruction calculator. | 2011-06-23 |
20110151505 | Substance for Specimen Preparations and Related Methods - Disclosed are substances and methods for preparing cytological specimens. | 2011-06-23 |
20110151506 | Process for Culturing Adherent Cells - The subject of the present invention is a process for producing adherent cells comprising:
| 2011-06-23 |
20110151507 | Solar Biofactory, Photobioreactors, Passive Thermal Regulation Systems and Methods for Producing Products - The invention described herein relates to photobioreactors, methods, assembly and use of such apparatus for culturing light-capturing organisms in a cost-effective manner. Various embodiments provide for a passive thermal regulation system employing selected microorganisms in a photobioreactor apparatus and methods for biological production of various fuel and chemical products from these organisms. Additional embodiments provide a solar biofactory system capable of culturing light capturing organisms to an areal productivity of 3.3 g/m2/hr. Further embodiments are directed to a photobioreactor capable of culturing light capturing organisms to an OD | 2011-06-23 |
20110151508 | BIODEGRADATION PROCESS AND COMPOSITION - Disclosed are novel microbial compositions and biodegradation processes to treat marine animal or marine animal by-products to produce solid, liquid and lipid fractions that contain useful compounds. | 2011-06-23 |
20110151509 | PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS - The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | 2011-06-23 |
20110151510 | Functional molecule and manufacturing method therefor - A novel method for efficiently manufacturing a functional molecule with affinity for a target substance is provided along with a functional molecule manufactured by this method. The method for manufacturing a functional molecule includes binding, to a resin, a specific substance having a cleavable linker which is a site that is cleavable under a specific condition to prepare a specific-substance-bound resin, treating this specific-substance-bound resin with a solution comprising functional molecule candidates, and then cleaving the cleavable linker under the specific condition to select a functional molecule which has interacted specifically with the specific substance. | 2011-06-23 |
20110151511 | RAPID GROWING MICROORGANISMS FOR BIOTECHNOLOGY APPLICATIONS - The present invention provides novel rapidly growing microorganisms and methods for their use in cloning or subcloning nucleic acid molecules. The rapid growing microorganisms of the present invention form colonies more rapidly than microorganisms typically used in molecular biology and thus provide a significant improvement in in vitro cloning methods used extensively in molecular biology. The invention also relates to kits and compositions used in the methods of the invention. | 2011-06-23 |
20110151512 | OLIGOPEPTIDE-FREE CELL CULTURE MEDIA - The present invention relates to oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine and to methods for cultivating cells in said oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine. The invention also relates to methods for expressing at least one protein in a medium comprising at least 0.5 mg/L of a polyamine and to methods for producing at least one virus in a medium comprising at least 0.5 mg/L of a polyamine. | 2011-06-23 |
20110151513 | SHRNA-MEDIATED INHIBITION OF EXPRESSION OF ALPHA-1,6-FUCOSYLTRANSFERASE - The current invention comprises a method for producing a heterologous polypeptide with a reduced degree of fucose modification in a mammalian cell by cultivating the mammalian cell under conditions suitable for the expression of said heterologous polypeptide, and recovering the heterologous polypeptide from the mammalian cell or the culture, wherein in said mammalian cell the enzymatic activity of α1,6-fucosyltransferase is reduced by means of an shRNA directed against α1,6-fucosyltransferase mRNA. | 2011-06-23 |
20110151514 | Vectors, Methods, Systems and Kits for Protein Purification - Disclosed herein are autocleaved peptide linkers for producing purified proteins. The autocleaved peptide linkers are inserted between a chitin binding protein (CBP) and a target protein to form a fusion protein. Upon expression of the fusion protein, it is allowed to pass a chitin matrix so that the CBP portion of the fusion protein may be bound with the chitin matrix, the peptide linker then undergoes auto-cleavage in a buffer solution at a pH value of about 5.5-7.5 to release the target protein. The chitin matrix may be regenerated with another buffer solution at a pH value of about 3-4, that is, to release the bound CBP and return to its unbound form. The chitin matrix may be reused for at least 6 times without losing its function. | 2011-06-23 |
20110151515 | PRODUCTION OF FC-FUSION POLYPEPTIDES IN EUKARYOTIC ALGAE - Methods and compositions are disclosed to engineer plastids comprising heterologous genes encoding immuno-activating domains fused to an extracellular domain (ECD) of a receptor or surface glycoprotein, a growth factor or an enzyme and produced within a subcellular organelle, such as a chloroplast. The immuno-activating domains may include those regions of a protein capable of modulating the interaction between immune effector cells via proteins containing stereoselective binding domains and specific ligands, such as the Fc regions of antibodies. The present disclosure also demonstrates the utility of plants, including green algae, for the production of complex multi-domain fusion proteins as soluble bioactive therapeutic agents. | 2011-06-23 |
20110151516 | PROCESS FOR THE EXTRACTION OF SUGARS AND LIGNIN FROM SOLID BIOMASS - A process for the extraction of sugars and/or lignin from lignocellulose-containing solid biomass is provided. | 2011-06-23 |
20110151517 | PROCESS FOR THE PREPARATION OF HOMOPOLYSACCHARIDES - A process for the preparation of aqueous solutions of glucans having a β-1,3-glycosidically-linked main chain and side groups having a β-1,6-glycosidic bond by fermentation of fungal strains. The fungal strains secrete the glucans into the fermentation broth, in an aqueous culture medium, and the separation of the glucans from the fermentation broth is effected using asymmetrical filter membranes. | 2011-06-23 |
20110151518 | METHOD FOR MODIFYING CHROMOSOMES - The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof. | 2011-06-23 |
20110151519 | Laboratory Apparatus with an Arrangement for the Tempering of Samples and Method of Tempering Samples - The invention relates to a laboratory apparatus, in particular for performing a polymerase chain reaction (PCR) in a plurality of PCR-samples, which comprises an arrangement for tempering samples, the arrangement comprising a tempering block for the tempering of samples, the tempering block comprising a reception side, which provides receptacles for receiving sample vessels, and a contact side for the contact of at least one tempering device, at least one tempering device, arranged in an area of said contact side, a pressure device, which comprises a pressure element and an auxiliary element, said at least one tempering device being arranged between said auxiliary element and the tempering block, the pressure element being linked to said auxiliary element and to the tempering block, and being arranged to press said at least one tempering device against the tempering block by pressing said auxiliary element against said at least one tempering device, wherein at least one tempering device is shaped and arranged in said area to at least partially surround by itself said pressure element. | 2011-06-23 |
20110151520 | Compositions and methods for cDNA synthesis - Methods for making cDNA molecules, for amplification of RNA by PCR and for preparation of cDNA libraries are provided. Kits for making cDNA molecules also are provided. | 2011-06-23 |
20110151521 | cDNA SYNTHESIS IMPROVEMENTS - The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention. | 2011-06-23 |
20110151522 | Glucoamylase Variants - The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates. | 2011-06-23 |
20110151523 | Nitrogen Compound Production Method and System - A nitrogen compound production method includes the step of establishing at least one aquatic plant in a cell containing water and alternating a step of inhibiting photosynthesis inducing light from reaching the at least one aquatic plant and a step of allowing photosynthesis inducing light to reach the at least one aquatic plant. The step of inhibiting photosynthesis inducing light defines a dark phase. A concentration of oxygen is reduced in the water to define an anoxic condition. During the anoxic condition, the at least one plant releases nitrogen compounds into the water and these nitrogen compounds are collected from the water contained in the cell. | 2011-06-23 |
20110151524 | PROCESS FOR PRODUCING BIODIESEL THROUGH LOWER MOLECULAR WEIGHT ALCOHOL-TARGETED CAVITATION - A method for producing fatty acid alkyl esters from biolipids through transesterification and/or esterification reactions uses a flow-through cavitation device for generating cavitation bubbles in a fluidic reaction medium. The fluidic medium is passed through sequential compartments in the cavitation device having varying diameters and inner surface features to create localized reductions in fluid pressure thus vaporizing volatile alcohols and creating an increased surface area and optimized conditions for the reaction to occur at the gas-liquid interface around the bubbles. | 2011-06-23 |
20110151525 | ENZYMATIC PRODUCTION OF UNSATURATED FATTY ACIDS ESTERS OF ASCORBIC ACID IN SOLVENT-FREE SYSTEM - The invention provides a cost-effective enzymatic process for the production of unsaturated FA esters of ascorbic acid, such as ascorbyl oleate or ascorbyl linoleate (E-304), in solvent-free system in which ascorbic acid esters of saturated FA, unsaturated free fatty acids and/or unsaturated fatty acid esters are used as feedstock. With this method pure products can even be achieved in a short response times. These products meet the needs of the industry by improving their solubility in oil and the increased antioxidant activity, especially in foods, cosmetics and medicine. | 2011-06-23 |
20110151526 | Branched-Chain Fatty Acids And Biological Production Thereof - A method for producing anteiso fatty acid is provided. The method comprises culturing a cell comprising at least one exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes at least one of the following reactions: conversion of pyruvate to citramalate; conversion of citramalate to citraconate; conversion of citraconate to β-methyl-D-malate; conversion of β-methyl-D-malate to 2-oxobutanoate; or conversion of threonine to 2-oxobutanoate, under conditions allowing expression of the polynucleotide(s) and production of anteiso fatty acid. Optionally the cell further comprises at least one exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes conversion of 2-oxobutanoate to 2-aceto-2-hydroxy-butyrate, conversion of 2-aceto-2-hydroxy-butyrate to 2,3-dihydroxy-3-methylvalerate, and/or conversion of 2,3-dihydroxy-3-methylvalerate to α-keto-3-methylvalerate. A cell that produces anteiso fatty acid and a method of using the cell to produce anteiso fatty acid also are provided. | 2011-06-23 |
20110151527 | PRODUCTION OF BIODIESEL, CELLULOSIC SUGARS, AND PEPTIDES FROM THE SIMULTANEOUS ESTERIFICATION AND ALCOHOLYSIS/HYDROLYSIS OF MATERIALS WITH OIL-CONTAINING SUBSTITUENTS INCLUDING PHOSPHOLIPIDS AND CELLULOSIC AND PEPTIDIC CONTENT - The present invention relates to a method for producing fatty acid alkyl esters as well as cellulosic simplified sugars, shortened protein polymers, amino acids, or combination thereof resulting from the simultaneous esterification and hydrolysis, alcoholysis, or both of algae and other oil containing materials containing phospholipids, free fatty acids (FFA), glycerides, or combination thereof as well as polysaccharides, cellulose, hemicellulose, lignocellulose, protein polymers, or combination thereof in the presence of an alcohol and an optional acid catalyst. | 2011-06-23 |
20110151528 | PROCESS FOR PRODUCING ORGANIC ACID - This invention is intended to improve the efficiency of organic acid fermentation in a simple manner without mutant breeding, DNA recombination breeding, or other means, when producing an organic acid via fermentation with the use of yeast that produces the organic acid of interest. The efficiency of the yeast's ability to produce organic acid is significantly improved by treating yeast that produces an organic acid in an organic-acid-containing medium having a low pH value. | 2011-06-23 |
20110151529 | METHODS AND PROCESSES FOR PRODUCING ORGANIC ACIDS - A fermentation process for the production of organic acids is provided and includes, providing metabolically engineered mutant bacteria which have had one or both of ack and pta genes disrupted, adapting the mutant bacteria to increase their resistance to acids and to increase their growth rate by immobilizing the mutant bacteria while exposing the mutant bacteria to a fermentable substrate, and further exposing the adapted mutant bacteria to a fermentable substrate for a time sufficient to provide a final organic acid fermentation product concentration of greater than about 50 g/L. | 2011-06-23 |
20110151530 | ENZYMATIC PRODUCTION OF 2-HYDROXY-ISOBUTYRATE (2-HIBA) - The present invention concerns a new method for the biological preparation of 2-hydroxy-isobutyrate (2-HIBA), including a fermentation method with microorganisms modified to favour production of 2-HIBA from renewable resources. The invention also concerns the modified microorganisms used in such fermentation method. | 2011-06-23 |
20110151531 | ETHANOL PRODUCTION BY MICROORGANISMS - The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium. | 2011-06-23 |
20110151532 | PAENIBACILLUS SPP. AND METHODS FOR FERMENTATION OF LIGNOCELLULOSIC MATERIALS - Provided herein are methods for producing a fermentation product, such as ethanol, by co-culture of a member of the genus | 2011-06-23 |
20110151533 | Biogasification of Coal to Methane and other Useful Products - Method of bioconversion of coal to methane, carbon dioxide, and other valuable gaseous and liquid products in a multi-step process that may include particle size reduction, separation of non-coal materials, addition of chemicals, and multi-stage anaerobic fermentation are disclosed. | 2011-06-23 |
20110151534 | INDUSTRIAL PRODUCTION OF ORGANIC COMPOUNDS USING RECOMBINANT ORGANISMS EXPRESSING METHYL HALIDE TRANSFERASE - The invention relates to a process for production of organic compounds using genetically engineered organisms expressing a S-adenosylmethionine (SAM)-dependent methyl halide transferase and, optionally modified at loci that affect flux through SAM metabolic pathways or affect intracellular halide levels. In one approach the organism, halides (chlorine, bromine and/or iodine); and a carbon source are incubated in a cultivation medium under conditions in which methyl halide is produced. The methyl halide may be collected and converted into non-halogenated organic molecules. | 2011-06-23 |
20110151535 | SEPARATION OF CULTURED CELLS - A first cell containing at least one magnetic particle is provided and a second cell is also provided. The second cell is cultured in the presence of the first cell. An alternating magnetic field is applied to the first cell. The alternating magnetic field at least partially separates the first cell from the second cell. | 2011-06-23 |
20110151536 | THROMBIN ACTIVATOR COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME - Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said polypeptides and recombinant systems for expressing said polypeptides. This disclosure also relates to methods for producing said compositions, recovering said compositions, activating said compositions purifying said compositions and producing active thrombin molecules using the active form of said compositions. | 2011-06-23 |
20110151537 | Synthetic Catalysts that Separate CO2 from the Atmosphere and Gas Mixtures - The creation of a catalyst that can be used for a wide variety of applications including the steps of developing preliminary information regarding the catalyst, using the preliminary information to produce a template of the catalyst, and using the template of the catalyst to produce the catalyst. | 2011-06-23 |
20110151538 | AFFINITY PURIFICATION BY COHESIN-DOCKERIN INTERACTION - The present invention is directed to truncated dockerin polypeptides, recombinant polypeptides and affinity systems comprising the truncated dockerin polypeptide, methods of generating same, and methods of use thereof to purify, isolate, and detect molecules of interest. | 2011-06-23 |
20110151539 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF - A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide. | 2011-06-23 |
20110151540 | PROCESS FOR THE PREPARATION OF A PHOSPHOLIPASE - A process for preparing a phospholipase D of vegetable or nut origin comprises: (i) providing a liquid extract of vegetable or nut origin; (ii) combining the liquid extract with a precipitating agent comprising at least one surfactant optionally in admixture with phospholipids, mono-, di- or triglycerides or a mixture thereof, to produce a suspension comprising a supernatant and a precipitate; and (iii) separating and collecting the precipitate from the suspension produced in (ii). | 2011-06-23 |
20110151541 | Method for Producing Recombinant Stem Bromelain - The present invention relates to a method for producing recombinant stem bromelain. Total RNA is isolated from pineapple plant ( | 2011-06-23 |
20110151542 | Bionanomaterials and Their Synthesis - The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed. | 2011-06-23 |
20110151543 | CELL SEPARATION METHOD USING HYDROPHOBIC SOLID SUPPORTS - Provided is a method of separating cells using a hydrophobic solid support. The method comprises contacting a solution containing cells with a hydrophobic solid support having a water contact angle between 70 and 90 degrees. By allowing cells to be adsorbed to the hydrophobic solid substrate, the cells can be separated. Thus, the cell separation efficiency can be rapidly and simply increased. | 2011-06-23 |
20110151544 | Geobacter Strains That Use Alternate Organic Compounds, Methods of Making, and Methods of Use Thereof - In preferred embodiments, the present invention provides new isolated strains of a | 2011-06-23 |
20110151545 | NON-PHOTOSYNTHETIC MICRO-ORGANISMS ENRICHED WITH ORGANIC SELENIUM FROM SELENO-HYDROXYACID COMPOUNDS AND APPLICATIONS THEREOF IN THE FIELDS OF NUTRITION, COSMETICS AND PHARMACUEUTICALS - The invention relates to the enrichment of non-photosynthetic micro-organisms with organic selenium, and more particularly with selenomethionine, from a compound of the seleno-hydroxyacid type such as 2-hydroxy-4-methylseleno-butanoic acid in the (D, L) form or in the form of an enantiomer, salt, ester, or amide derivative of said compound, and to the use of micro-organisms, particularly bacteria thus enriched in the fields of animal or human nutrition, cosmetics, or pharmaceuticals. | 2011-06-23 |
20110151546 | GLYCOPEPTIDE ANTIBIOTICS - The invention provides compounds of formula | 2011-06-23 |
20110151547 | REACTOR AND METHOD FOR TREATING CONTAMINATED WATER - A reactor and method are presented for processing water, in a manner enabling treatment of contaminated water to produce purified water and enabling simultaneous production of a biomass. The reactor comprises first and second compartments interfacing one another by a gas-permeable membrane. The first compartment serves for interaction between the water and at least one species of aerobic heterotrophic microorganism which are adapted to break down one or more organic contaminants in the contaminated water. The second compartment serves for interaction between the water and at least one species of phototrophic microorganism capable of producing oxygen. The gas-permeable membrane prevents transfer of the organic contaminant therethrough, while allows gas diffusion therethrough. As a result, oxygen, produced by the phototrophic microorganism in the second compartment, is allowed to pass into the first compartment thus facilitating breakage down of the one or more contaminants of the contaminated water in the first compartment. | 2011-06-23 |
20110151548 | GREASE ABSORPTION SYSTEM AND METHOD - An improvement is provided in grease trap assemblies for grease traps to be positioned on the roof of commercial buildings such as restaurants. The improvement comprises a system for degreasing that uses, in combination, a grease absorbent material that is porous rock, preferably lava, and a grease digestible microbe capable of digesting fatty acids from cooking fats and oils. Each can as well be used alone, but best results are achieved with the combination. | 2011-06-23 |
20110151549 | Device For Carrying Out An Individual Immunoassay In A Fully Automatic Manner - The invention relates to a device for carrying out an individual immunoassay in a fully automatic manner in order to detect the presence of a biologically active substance in a sample, and to the use of one such device. The invention also relates to a sample strip which, in order to carry out an individual immunoassay for the detection of a biologically active substance in a sample using the above-mentioned device, comprises a plurality of cavities for providing the reagents required for the assay. The sample strip is sealed with a film carrying a code specific to the assay. | 2011-06-23 |
20110151550 | System For Multi Color Real Time PCR - The invention is directed to a system for performing multi-color real time PCR, comprising a flexible real time PCR instrument and a specific composition or reaction mixture for performing multiplex PCR: In particular, the present invention is directed to a composition or reaction mixture which comprises at least 3, preferably 4-5 and most preferably exactly 4 pairs of FRET hybridization probes. Each pair of said hybridization probes consists of a FRET donor probe carrying a FRET donor moiety and a FRET acceptor probe carrying a FRET acceptor moiety having an emission maximum between 550 and 710 nm. | 2011-06-23 |
20110151551 | BIOREACTORS - The present invention relates to improved single-use bioreactors comprising disposable plastic bags for cell cultivation. The invention provides an inflatable bioreactor bag for cell cultivation comprised of a top and a bottom sheet of polymer material that are joined along their edges to form a sealed bag, wherein two opposing edges are formed as clamping edges to allow clamping of the bioreactor bag to a rocker type bioreactor, and wherein the bioreactor bag is provided with a wrinkle preventing structure at each end of the clamping edges. The bag avoids formation of undesired wrinkles or creases which otherwise lead to fatigue of the plastic and eventually fracture. | 2011-06-23 |
20110151552 | BIOREACTORS - The present invention relates to improvements of bioreactor bags for cell cultivation. The invention provides an inflatable bioreactor bag for cell cultivation comprised of a top and a bottom sheet of polymer material that are joined along their edges to form a sealed bag, wherein two opposing edges are formed as clamping edges to allow clamping of the bioreactor bag to a rocker type bioreactor, wherein the top sheet is at least 5% longer than the bottom sheet between the clamping edges. The bioreactor bags provided by the invention avoid formation of undesired wrinkles or creases which otherwise may lead to fatigue of the plastic and eventually fracture. | 2011-06-23 |
20110151553 | Device and Method for Composting - A composter device is provided including a mixer and a grinder commonly driven and commonly located in a composting chamber of the device. A large opening at the top of the composting chamber permits large objects to be inserted into the chamber to permit the object to be ground and left to decompose to produce compost material in the same chamber. The grinder includes grinding elements arranged to produce a shearing action while the mixer includes an auger to produce a churning action when the ground matter requires periodic mixing during the decomposition process to produce compost. | 2011-06-23 |
20110151554 | METHOD FOR CULTURING AND SUBCULTURING PRIMATE EMBRYONIC STEM CELL, AS WELL AS METHOD FOR INDUCING DIFFERENTIATION THEREOF - The present invention provides a method for subculturing primate embryonic stem cells, and a method for inducing differentiation of the same cell into a vascular endothelial cell and a blood cell. The present invention provides a method comprising culturing primate embryonic stem cells in a medium containing a protein component without using feeder cells and cytokines in a container coated with an extracellular matrix, detaching colonies of the resulting embryonic stem cells in the presence of a cytodetachment agent, and plating the colonies in the similar medium, and a method comprising culturing primate embryonic stem cells in a serum-containing or not containing medium in the presence of cytokine, adhesion-culturing the resulting embryoid body or embroyid body-analogous cellular aggregate in the presence of a cytokine to obtain specific precursor cells, and separating non-adherent cells and adherent cells from the specific precursor cells to obtain blood cells and vascular endothelial precursor cells. | 2011-06-23 |
20110151555 | Compositions and methods for growing human embryonic cells - Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic gem (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or extracellular matrix, typically human derived. | 2011-06-23 |
20110151556 | METHODS FOR ISOLATING MONONUCLEAR CELLS THAT INCLUDE A SUBPOPULATION OF MESENCHYMAL PROGENITOR CELLS AND VASCULAR CELLS THAT INCLUDE A SUBPOPULATION OF ENDOTHELIAL PROGENITOR CELLS FROM UMBILICAL CORD TISSUE - Provided herein are methods and kits for the isolation, processing and cryopreservation of mesenchymal cells from the Wharton's Jelly and vascular progenitor cells from umbilical cord tissue. Also provided are isolated mesenchymal cells or vascular progenitor cells obtained by the invention methods, and compositions thereof. | 2011-06-23 |
20110151557 | COMPOSITIONS AND METHODS FOR TRANSFECTION OF RNA AND CONTROLLED STABILIZATION OF TRANSFECTED RNA - The present invention provides reagents and methods for RNA transfection and protein expression | 2011-06-23 |
20110151558 | METHODS AND COMPOSITIONS FOR REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS - The present invention concerns methods and compositions involving the production or generation of siRNA mixtures or pools capable of triggering RNA-mediated interference (RNAi) in a cell. Compositions of the invention include kits that include reagents for producing or generating siRNA pools. The present invention further concerns methods using polypeptides with RNase III activity for generating siRNA mixtures or pools that effect RNAi, including the generation of a number of RNA molecules to the same target gene. | 2011-06-23 |
20110151559 | Compounds for Modulating TRPV3 Function - The present application relates to compounds and methods for treating pain and other conditions related to TRPV3. | 2011-06-23 |
20110151560 | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS - The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon. | 2011-06-23 |
20110151561 | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS - The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to increase the expression of NGN3 and NKX6.1 in populations of cells expressing markers characteristic of the pancreatic endocrine lineage. | 2011-06-23 |
20110151562 | WHITE BLOOD CELL DIFFERENTIATION REAGENT AND METHOD - A reagent for four-part differentiation of white blood cells is provided. In one embodiment the reagent has an osmolality below 50 mOsm/kg H | 2011-06-23 |
20110151563 | Collagen Materials, Films and Methods of Making Same - In general, the present invention is related to collagen compositions and thin films, and to methods of making and using the same. In some embodiments, the present invention is directed to “woven pattern” or “basket pattern” collagen compositions and thin films, and methods of making. | 2011-06-23 |
20110151564 | METHOD FOR PROLIFERATION OF CELLS ON POLYELECTROLYTE MULTILAYER FILMS AND USE THEREOF, PARTICULARLY FOR THE PREPARATION OF CELLULAR BIOMATERIALS - The invention relates to the use of a unit including a substrate and polyelectrolyte multilayer films deposited thereon in order to: carry out a method involving the proliferation of initial stem or differentiated cells that are brought into contact with the unit; and cover the unit with confluent viable adherent cells resulting from the proliferation of the initial cells, the cover being obtained at the end of a period of no more than one month, such as 14 days, 11 days or, in particular, 7 days, after the initial cells are brought into contact with the unit. | 2011-06-23 |
20110151565 | CELL SHEET HAVING GOOD DIMENSIONAL STABILITY, METHOD FOR PRODUCTION THEREOF, AND CELL CULTURE CARRIER FOR USE IN THE METHOD - It is an object of the present invention to provide a cell culture carrier for producing a cell sheet that can be readily detached from a cell culture carrier and is inhibited from contracting after being detached. | 2011-06-23 |
20110151566 | BIODEGRADABLE POLYMERS, COMPLEXES THEREOF FOR GENE THERAPEUTICS AND DRUG DELIVERY, AND METHODS RELATED THERETO - A biodegradable cationic polymer is disclosed, comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a subunit derived from a monomeric diol initiator for the ring-opening polymerization; and an optional endcap group. The biodegradable cationic polymers have low cytotoxicity and form complexes with biologically active materials useful in gene therapeutics and drug delivery. | 2011-06-23 |
20110151567 | Recombinant Microorganism - A recombinant microorganism having improved productivity for a protein or a polypeptide, and a method for producing a protein or a polypeptide using the recombinant microorganism, are provided. A recombinant microorganism obtained by transfecting a gene for encoding a desired protein or polypeptide into a microorganism strain which is obtained by genetically constructing to overexpress secY gene of | 2011-06-23 |
20110151568 | Assay for Monitoring Parathyroid Hormone (PTH) Variants by Tandem Mass Spectrometry - Methods are described for monitoring the amounts of PTH variants in a biological sample by digesting the sample to produce surrogate peptides specific to the targeted PTH variants, and detecting and quantifying the surrogate peptides by selective reaction monitoring (SRM) mass spectrometry, using a set of precursor-to-product ion transitions optimized for sensitivity and selectivity. The PTH variants, or a portion thereof, may be concentrated in the sample by means of immunoaffinity capture or other suitable technique. The mass spectrometric method described herein enables the concurrent measurement of peptides representative of a plurality of targeted PTH variants in a single assay. | 2011-06-23 |
20110151569 | IDENTIFICATION OF SAMPLE COMPONENTS - The present disclosure relates to the identification of components in a sample based on the chemical nature of the component. In particular, although not exclusively, the present disclosure relates to the identification of hydrophobic and hydrophilic components using a mass spectrometric technique. The present invention also relates to kits and products used in the identification of the components, as well as other subject matter. | 2011-06-23 |
20110151570 | METHOD FOR ON-SITE DRUG DETECTION IN ILLICIT DRUG SAMPLES - The invention is provided for detection of Heroin and Morphine in illicit drug samples, also for their differentiation. A liquid sample from a street sample is prepared and divided into two equal aliquots, one of them being reference sample, another being main sample. Both samples are treated with Hydrochloric acid and Sodium hydroxide, but those substances are added to the samples in the different sequence. After that the measurement of SFS of the reference sample is performed. Further the presence of specific spectral pattern of Morphine in the measured SFS of the reference, sample is detected and the value of SFS intensity at the specific spectral point is fixed (a reference value). After 15 minutes for acidification of the main sample, the analogous measurement and detection of the Morphine in the main sample are performed. | 2011-06-23 |
20110151571 | MEMORY APPARATUS FOR MULTIUSE ANALYTE TEST ELEMENT SYSTEMS, AND KITS, SYSTEMS, COMBINATIONS AND METHODS RELATING TO SAME - One embodiment includes a memory unit for use in connection with a plurality of fluid sample test elements, wherein the memory unit comprises a plurality of memory portions. In one aspect of the embodiment, the memory unit comprises at least one memory portion configured to communicate calibration and expiration information relating to a lot of test elements, to a meter operably connectable with such test elements, and at least one other memory portion configured for storage and communication of data, such as measurement results, relating to the use of the test elements in analyzing a fluid sample. Further embodiments include apparatuses, systems, methods, kits and combinations of test elements and memory units. | 2011-06-23 |
20110151572 | METHOD, DEVICE AND APPARATUS FOR MEASURING THE CONCENTRATION OF CREATININE, AND METHOD, DEVICE AND APPARATUS FOR MEASURING THE AMOUNT OF SALT IN URINE USING THE SAME - A method for measuring the concentration of creatinine includes the steps of: (A) mixing a sample containing creatinine with a creatinine quantitative reagent including 1-methoxy-5-methylphenazinium in the absence of picric acid and any enzyme responsive to creatinine, to cause the creatinine to reduce the 1-methoxy-5-methylphenazinium; (B) electrochemically or optically measuring the amount of the 1-methoxy-5-methylphenazinium reduced in the step (A); and (C) determining the concentration of the creatinine contained in the sample from the amount of the reduced 1-methoxy-5-methylphenazinium measured in the step (B). | 2011-06-23 |
20110151573 | Nanoporous Detectors of Monocyclic Aromatic Compounds and Other Pollutants - Porous sol-gel material essentially consisting of units of one or more first polyalkoxysilanes chosen from the following compounds: (chloromethyl)triethoxysilane; 1,3-dimethyltetramethoxydisiloxane; ethyl trimethoxysilane; triethoxy(ethyl)silane; triethoxymethylsilane; triethoxy(vinyl)silane; trimethoxymethylsilane; trimethoxy(vinyl)silane; tetraethoxysilane or tetramethoxysilane (TMOS) and of units of one or more second polyalkoxysilanes chosen from the following compounds: (N-(3-(trimethoxysilyl)propyl)ethylenediamine; 3-aminopropyltriethoxysilane (APTES) and 3-aminopropyltrimethoxysilane, in a first polyalkoxysilane/second polyalkoxysilane molar ratio of 1/0.01 to 1/1, optionally comprising a probe molecule, method of preparation and applications in the trapping of monocyclic aromatic hydrocarbons and other pollutants or in their detection. | 2011-06-23 |
20110151574 | DETECTION OF TRACE CHEMICALS AND METHOD THEREFOR - The invention provides devices, systems, and methods for detecting an analyte vapor. Particularly, electronegative analyte vapors, such as those vapors evolving from explosive compounds, are typical analytes detected the devices. The devices operate using a resistivity change mechanism wherein a nanostructured chemiresistive material undergoes a resistivity change in the presence of an analyte vapor. A resistivity change indicates the presence of an analyte. | 2011-06-23 |
20110151575 | Energetic Material Detector - Energy released from energized particles is sensed. Whether the energized particles include a possible energetic material is determined based on the sensed energy. If a determination is made that the energized materials include a possible energetic material, a spectral signature of the sensed energy is determined. The spectral signature of the sensed energy is compared to one or more known spectral signatures associated with energetic materials. Whether the possible energetic material is an actual energetic material is determined based on the comparison. | 2011-06-23 |