25th week of 2017 patent applcation highlights part 44 |
Patent application number | Title | Published |
20170176363 | Measurement Device for Measuring a Property of a Flowing Fluid - A measurement device, in particular an electromagnetic flow meter, for measuring a flow, of a flowing fluid, comprising a measurement tube having an outer tube and a liner lining an inside of the outer tube, and a measurement structure for measuring a property of a fluid flowing through the lined measurement tube during measurement operation, capable of detecting abrasion of the liner. The liner consists of a thermally insulating material, in particular a rubber or a plastic material, structure are foreseen for measuring a temperature gradient (ΔT) across a measurement tube wall of the measurement tube, when the measurement tube wall is exposed to a temperature difference (ΔT | 2017-06-22 |
20170176364 | METAL DETECTION APPARATUS - A metal detector has a transformer unit ( | 2017-06-22 |
20170176365 | SYSTEM DEVICE AND METHOD FOR TESTING AN OBJECT - A system and method for characterizing non-solid substances, the system comprising a housing body having a cavity | 2017-06-22 |
20170176366 | In-Vitro Sensor Using a Tetrapolar Impedance Measurement - Systems, methods, and devices are provided for determining an impedance measurement of a sample of fluid on a test strip having a base layer, at least two drive electrodes disposed on the base layer and in electrical communication with a current-source (I | 2017-06-22 |
20170176367 | APPARATUS TO MEASURE CONDUCTIVITY OF NON-AQUEOUS LIQUIDS AT VARIABLE TEMPERATURES AND APPLIED VOLTAGES - A conductivity meter for measuring the conductivity of a sample of non-aqueous liquid. The conductivity meter includes a conductivity cell which contains the sample and which is disposed within a heater block which can control the temperature of the sample and a pressure vessel which can control the surrounding pressure for the conductivity cell. A probe senses conductivity of the sample as a voltage is applied across the sample. | 2017-06-22 |
20170176368 | APPARATUS TO MEASURE CONDUCTIVITY OF NON-AQUEOUS LIQUIDS AT VARIABLE TEMPERATURES AND APPLIED VOLTAGES - A conductivity measurement apparatus for measuring the conductivity of a non-aqueous sample. The conductivity measurement apparatus includes a conductivity cell which contains the sample and which is disposed within a heater block which can control the temperature of the sample and a pressure vessel which can control the surrounding pressure for the conductivity cell. A probe senses conductivity of the sample as a voltage is applied across the sample. | 2017-06-22 |
20170176369 | SYSTEM AND METHOD FOR SENSING OIL QUALITY - A system for measuring the state of degradation of cooking oil in a deep fryer is provided. The system includes a loop of piping fluidly connected to a fryer for selectively allowing flow of oil from the fryer and into the loop and for returning to the fryer. A pump urges the flow of cooking oil through the loop of piping and selectively to urge oil to return to the at least one fryer pot. The loop further comprises a return portion that extends from a discharge of the pump toward a suction of the pump. A sensor is disposed in the return portion of the loop and adapted to measure an electrical property that is indicative of total polar materials of said cooking oil. A vent line is provided in the return portion of the loop. | 2017-06-22 |
20170176370 | GRAPHENE OXIDE SENSORS - Articles and methods involving sensors and thin films suitable for use in sensors are generally provided. In some embodiments, the sensors may comprise a graphene oxide component and/or a thin film with a percolated structure. The sensors may have one or more advantageous properties, such as an appropriate value of resistance, a high degree of sensitivity, and a low response time. | 2017-06-22 |
20170176371 | METHOD AND DEVICE FOR PRODUCING A REFERENCE ELECTRODE - The present disclosure relates to a method for producing a reference electrode, wherein an internal space of the reference electrode is delimited by an outer wall and wherein the internal space contains a reference electrolyte up to a specified height, wherein the reference electrode is introduced into a pressurization chamber, wherein a defined overpressure is applied to the pressurization chamber and, via an opening that is located above the specified height in the outer wall of the reference electrode to the internal space of the reference electrode, and wherein the opening in the outer wall of the reference electrode is closed at the defined overpressure . The present disclosure further relates to a device for carrying out the method. | 2017-06-22 |
20170176372 | INLINE SENSOR ARRANGEMENT AND METHOD FOR COMMISSIONING SAME - The present disclosure includes an inline sensor arrangement and a method for bringing an inline sensor arrangement into service, where the inline sensor arrangement includes a sensor embodied to produce and to output a measurement signal correlated with the measured variable, and where the sensor has at least one sterile sensor element for contact with the measured medium and at least one housing, which surrounds the sensor element and encloses the sensor element in a chamber sealed from an environment of the housing. The method includes performing a heat sterilization of at least one part of the inline sensor arrangement comprising a housing exterior of the housing, opening the housing after terminating the heat sterilization, and bringing the sensor element into contact with the measured medium. | 2017-06-22 |
20170176373 | MEASURING DEVICE, MEASURING METHOD, AND SUPPLY DEVICE - A measuring device includes a detecting unit including a conductive layer (a current measuring unit) configured to measure a value of an electric current that fluctuates according to the concentration of a measurement target substance, a temperature sensor (a temperature measuring unit) configured to measure an environmental temperature of an environment in which the conductive layer is placed, a storing unit configured to store, as a plurality of combinations, analytical curves of current fluctuation width due to a shift (Δt) of the environmental temperature from a set temperature and the concentration of the measurement target substance, and a computing unit configured to derive the concentration of the measurement target substance from the shift (Δt) of the environmental temperature from the set temperature, the current value, and the analytical curves. | 2017-06-22 |
20170176374 | METHOD FOR MEASURING TEMPERATURE OF BIOLOGICAL SAMPLE, MEASURING DEVICE, AND BIOSENSOR SYSTEM - The concentration measurement method includes: introducing a predetermined amount of the biological sample into the capillary; measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample; measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; measuring an environmental temperature in a surrounding of the biological sample; and correcting the concentration of the measured analyte based on the measured temperature of the biological sample and the measured environmental temperature. | 2017-06-22 |
20170176375 | MEMBRANE AND METHOD OF MANUFACTURE - The present disclosure concerns a membrane for a sensor, such as an opto-chemical or electrochemical sensor, including a polymer layer, for example, one featuring pores or openings, that is permeable to a measuring fluid and/or an analyte contained in the measuring fluid, with a surface designed to be in contact with a measuring fluid, wherein the surface is designed such that, at least in a moist condition of the polymer layer obtained by moistening the surface, a contact angle of a water drop applied to the surface is less than 50°, including less than 30°, and including less than 10°. | 2017-06-22 |
20170176376 | LIGHT-ADDRESSABLE POTENTIOMETRIC SENSING UNITS - Light-addressable potentiometric sensing units are provided. A light-addressable potentiometric sensing unit comprises a conductive substrate, a metal oxide semiconductor layer, and a sensing layer. The metal oxide semiconductor layer is made of indium gallium zinc oxide, indium gallium oxide, indium zinc oxide, indium oxide co-doped with tin and zinc, tin oxide, or zinc oxide. The wide-band gap characteristic of the metal oxide semiconductor layer enables the light-addressable potentiometric sensing unit to resist the interference from visible light. The light-addressable potentiometric sensing unit therefore exhibits a more stable performance. | 2017-06-22 |
20170176377 | PULSED POTENTIAL GAS SENSORS - A method of operating an electrochemical gas sensor, which includes at least one working electrode including an electrocatalyst and having a ratio of total electrochemically accessible surface area to geometrical surface area of at least 2:1, includes alternatively biasing a potential of the at least one working electrode to a first potential at which the electrocatalyst is active to catalyze a redox reaction of a first target gas and to a second potential, different from the first potential, at which the electrocatalyst is substantially inactive to catalyze the redox reaction of the first target gas, a plurality of times, measuring a first output signal arising from the redox reaction of the first target gas at the first potential, and deconvoluting the first output signal while the at least one working electrode is biased at the first potential to separate a portion of the first output signal arising from non-faradaic current to determine a concentration of the first target gas. | 2017-06-22 |
20170176378 | GAS COMPONENT CONCENTRATION MEASUREMENT DEVICE AND METHOD FOR GAS COMPONENT CONCENTRATION MEASUREMENT - A measuring device for measuring a concentration of a gas component in a gas includes a flow generating device, a first conduit, a second conduit, and an electrochemical detector configured for sensing the gas component concentration in the gas. The first and second conduits are arranged in parallel, and the flow generating device is connected with an inlet of the first conduit and an inlet of the second conduit. The flow generating device is arranged for generating a gas flow in each of the conduits. The measuring device is arranged to alternately couple either an outlet of the first conduit or an outlet of the second conduit to an inlet of the detector, wherein the first conduit is provided with a reactant for absorbing or stripping the gas component. | 2017-06-22 |
20170176379 | Label Free Analyte Detection by Electronic Desalting and Field Effect Transistors - Provided are methods and devices for the label free detection of analytes in solution, including analytes suspended in a biological fluid. A field effect transistor (FET) is positioned in close proximity to a paired set of reference electrodes and the reference electrodes electrically biased to provide desalting and a stable gate voltage to the FET. In this manner, charged ions are depleted in the sensing region of the sensor and device sensitivity to analyte detection improved by the removal of charge that otherwise interferes with measurement. Also provided are methods and systems providing increased in reference electrode surface area and/or decrease in droplet volume to further improve label-free detection of analytes. | 2017-06-22 |
20170176380 | FIELD-EFFECT SENSOR AND ASSOCIATED METHODS - An apparatus comprising: a first layer ( | 2017-06-22 |
20170176381 | APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS, DEVICES, AND RELATED METHODS - A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters. | 2017-06-22 |
20170176382 | ELECTROPHORESIS DEVICE - A capillary electrophoresis device including a capillary tube, a suction pump for taking liquid, an intake tube whose end is formed vertically downward, a connection block in which there is an intake flow path that holds the end of the capillary tube and connecting the suction pump to the intake tube, a sample storage unit which contains a sample and has an upward opening into which the tip of the intake tube may be inserted, an intake tube access mechanism to insert the tip of the intake tube into the sample storage unit, and a voltage application mechanism that applies an electric potential difference across the capillary tube. | 2017-06-22 |
20170176383 | DEVICES AND METHODS FOR CONTAINING MOLECULES - The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically containing (e.g., trapping) a molecule (e.g., a biomolecule), e.g., for minutes, hours, or days. In certain embodiments, the method comprises urging a molecule into a cavity of a device by application of an electric field, and/or by deposition of fluids having different ionic strengths. The molecule may comprise, in some cases, nucleic acids (e.g., DNA). The molecule, when present in the cavity and/or the nanopore, may be capable of being analyzed, determined, or chemically modified. In some instances, a second molecule (e.g., a second molecule which interacts the first molecule) may also be urged into the cavity. In some embodiments, the interaction of the second molecule with the first molecule (e.g., the second molecule binding to or chemically modifying the first molecule) may be determined by, for example, a change in voltage measured across the device. | 2017-06-22 |
20170176384 | Apparatuses, Systems and Methods for Sequencing Using Capillary Electrophoresis - In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries. | 2017-06-22 |
20170176385 | Capillary Array Cartridge for Capillary Electrophoresis Systems - The present disclosure relates, in some embodiments, to an apparatus for conducting a capillary electrophoresis assay. The apparatus can comprise a capillary array comprising an anode end and a cathode end, the capillary array provided in a housing further comprising a reservoir configured to house a separation medium and an anode buffer. The system can also comprise an injection mechanism configured to deliver sample to the cathode end of the capillary array, and a temperature control zone, wherein the temperature control zone is configured to control the temperature of the interior of the housing. | 2017-06-22 |
20170176386 | DEVICES AND METHODS FOR SAMPLE CHARACTERIZATION - Devices and methods for characterization of analyte mixtures are provided. Some methods described herein include performing enrichment steps on a device before expelling enriched analyte fractions from the device for subsequent analysis. Also included are devices for performing these enrichment steps. | 2017-06-22 |
20170176387 | DEVICE AND METHOD FOR CALCULATING TRAPPING PARAMETERS BY MEASURING SHORT-CIRCUIT CURRENT DECAY UNDER REVERSE BIAS VOLTAGE - A device for calculating trapping parameters by measuring short-circuit current decay under a reverse bias voltage, including: a vacuum chamber, an experiment table, a lower electrode, a shielding layer, an upper electrode, a direct current charging module, a switch, a short-circuit measuring system, and a computer. The experiment table, the lower electrode, the shielding layer, the test sample, and the upper electrode are disposed from the bottom up in that order inside the vacuum chamber. The upper electrode is connected to the direct current charging module via the switch. The upper electrode and the lower electrode are electrically connected via the short-circuit measuring system. The short circuit or the detrapping current measuring circuit is selectively electrically connected under the control of the selective switch. The reverse bias voltage source and the microammeter are connected in series. | 2017-06-22 |
20170176388 | METAL DETECTION APPARATUS, TESTING DEVICE AND METHOD FOR OPTIMISING A METAL DETECTION APPARATUS - An apparatus ( | 2017-06-22 |
20170176389 | METHOD AND SYSTEM FOR NON-DESTRUCTIVE RAIL INSPECTION - The present invention relates to a method for identifying and locating a defect in a metal rail, and includes the steps of positioning a first magnetic sensor at a distance above a rail, the first magnetic sensor being configured to measure a magnetic field of the rail; advancing the sensor along a length of the rail; sampling magnetic field measurements; determining multiple magnetic field gradients over different pluralities of samples; identifying a defect in the rail based on a change in one or more of the magnetic field gradients; and determining a position of the defect at a particular distance from the magnetic sensor based on a degree of variation in the magnetic field gradients. | 2017-06-22 |
20170176390 | Method for Detecting Defect of Pipe, Device for Detecting Defect of Pipe, Apparatus for Detecting Defect of Pipe - A method for detecting the defect of the pipe includes the steps of: detecting a first parameter related to a magnetic induction intensity along a length direction of the pipe; determining whether the first parameter exceeds a predetermined threshold; determining a position at which the first parameter exceeds the predetermined threshold as the position of the defect of the pipe; and determining a degree of the defect of the pipe based on a numerical value of the first parameter exceeding the predetermined threshold. Through the detecting device, the defect in the pipe is decided based on parameters related to the magnetic induction intensity, the position of the defect of the pipe is determined according to a position at which the parameters are abnormal, and the degree of the defect of the pipe is determined according to numerical values of the parameters which are abnormal. | 2017-06-22 |
20170176391 | Micro-magnetic Detecting Method and Micro-magnetic Detecting Device - A micro-magnetic detecting method includes the steps of: detecting a magnetic induction intensity along a first direction on a surface of a detected object to generate a detection signal, determining whether an amplitude of the detection signal is an anomalous value at a first position of the surface of the detected object, wherein the anomalous value is a value which is inconsistent with a linear value of the detection signal at the first position, and the linear value is a value that satisfies a linear relationship of the detection signal, and determining there is a defect at the first position of the detected object in case that the amplitude of the detection signal is the anomalous value. Accordingly, it detects the magnetic induction intensity on the surface of the detected object so as to detect its surface and internal defects when it remains in its original status. | 2017-06-22 |
20170176392 | COMPONENT-EMBEDDED SUBSTRATE AND SUBSTRATE FLAW DETECTING METHOD - A component-embedded substrate includes a multilayer body including a plurality of insulating layers stacked in a stacking direction, an embedded component embedded in the multilayer body, and planar conductors disposed on both sides of the embedded component in the stacking direction, the planar conductors overlapping the embedded component. The planar conductors each include a plurality of openings that overlap the embedded component over substantially the entire region occupied by the embedded component, as seen in the stacking direction. | 2017-06-22 |
20170176393 | Composite Inspection - A method of detecting material changes in a composite structure is presented. A pulsed laser beam is directed towards the composite structure comprised of a number of composite materials. Wide-band ultrasonic signals are formed in the composite structure when radiation of the pulsed laser beam is absorbed by the composite structure. The wide-band ultrasonic signals are detected to form data. The data comprises a number of ultrasonic A-scans. The data is processed to identify a plurality of frequency measurements for each of the number of ultrasonic A-scans. A frequency image is displayed using the plurality of frequency measurements. The material changes are represented in the frequency image. | 2017-06-22 |
20170176394 | ULTRASONIC MONITORING OF ELECTRICAL CONNECTIONS - According to one aspect, embodiments herein provide an electrical connection sensor comprising at least one transducer configured to be coupled to a power distribution block, to generate ultrasonic pulses in the power distribution block, and to receive ultrasonic signals based on the ultrasonic pulses, and a controller coupled to the at least one transducer and configured to determine a status of at least one electrical connection in the power distribution block based on at least one characteristic of the ultrasonic signals received by the at least one transducer. | 2017-06-22 |
20170176395 | NOISEMAKER FOR PIPE SYSTEMS - A noisemaker system includes a node of an infrastructure system; and a noisemaker connected in fluid communication with the node, the noisemaker including a noisemaker housing defining a noisemaker cavity, and a pulsing device positioned within the noisemaker cavity, the pulsing device configured to contact a fluid within the noisemaker cavity and generate an acoustic signal within the fluid. | 2017-06-22 |
20170176396 | PROBE, OBJECT INFORMATION ACQUISITION APPARATUS, AND METHOD OF MANUFACTURING THE PROBE - A probe configured to receive an acoustic wave from an object including an element having a cell structure, in which a vibration membrane having one of a pair of electrodes formed with a gap arranged therebetween is supported so that the vibration membrane can be vibrated by the acoustic wave; a light reflection layer provided at a position near the object with respect to the element and configured to reflect light; and a support layer provided between the element and the light reflection layer and configured to support the light reflection layer. | 2017-06-22 |
20170176397 | Ultrasonic Testing Device and Ultrasonic Testing Method - The invention is applied to an ultrasound inspection apparatus including an array probe such that wetting is substantially limited to an inspection surface of the work. The ultrasound inspection apparatus includes: a work holder that holds a work with an inspection surface thereof facing downward; an array probe that probes the work with an ultrasonic wave; a water tank in which the array probe is immersed in water; an arm that holds the array probe such that the array probe faces an underside of the inspection surface of the work; X-axial direction scanning means that horizontally scans the work, with a liquid surface coming into contact with the inspection surface of the work due to surface tension of a liquid stored in the water tank; and Y-axial direction scanning means that horizontally scans the array probe. | 2017-06-22 |
20170176398 | COUPLANT AND ARRANGEMENT OF COUPLANT, TRANSDUCER, AND CONSTRUCTION COMPONENT - Embodiments provide a couplant and an arrangement of a couplant, a transducer, and a construction component. The couplant is adapted to couple the transducer to the surface of the construction component. The couplant provides 36% to 40% mass portion of hard metal. | 2017-06-22 |
20170176399 | OBJECT INFORMATION ACQUIRING APPARATUS AND CONTROL METHOD THEREOF - An object information acquiring apparatus according to the present invention includes: a probe including a plurality of transducers that convert an acoustic wave from measurement object to an electrical signal; a positional information acquirer that acquires positional information on the transducers; and a characteristic information acquirer that acquires characteristic information on the measurement object, based on the electrical signal and the positional information, wherein the positional information acquirer acquires a first data group which is a distance between the first position and each of the plurality of transducers; calculates a second data group which is a distance between the point sound source and each of the plurality of transducers. | 2017-06-22 |
20170176400 | DUAL ONLINE LIQUID CHROMATOGRAPHY DEVICE AND CONTROL METHOD THEREOF - A dual online liquid chromatography device according to an embodiment of the present invention comprises: a first pump for injecting a first solvent or a mixed solution containing the first solvent and a second solvent; a second pump for injecting the first solvent or the mixed solution containing the first and second solvents; a specimen intake valve connected to the first pump and a specimen injector for injecting a specimen; a column selection valve connected to the second pump and the specimen intake valve; and a dual column valve including a plurality of ports, one side of which is connected to the column selection valve and an opposite side of which is connected to a first column and a second column. | 2017-06-22 |
20170176401 | Secondary Ultrasonic Nebulisation - A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample. | 2017-06-22 |
20170176402 | METHOD AND MEASURING APPARATUS FOR DETERMINING GAS PROPERTIES BY CORRELATION - A method in which a gas property (Q) is determined by correlation from physical measuring quantities (μ | 2017-06-22 |
20170176403 | HYDROGEN CONCENTRATION MEASURING DEVICE - Provided is a hydrogen concentration measuring device capable of measuring with high accuracy a hydrogen concentration over an extensive range by a simple configuration. The device includes: a sensor chip which detects the electric resistance of a sensing film; an optical measurement unit which detects the transmitted light intensity of the film; and a controller. The controller performs measurement processing such that a hydrogen concentration in the gas atmosphere is measured based on the detected electric resistance in a first measurement range and based on the detected transmitted light intensity in a second measurement range and is determined so as to reduce a difference between the hydrogen concentration based on the detected electric resistance and the hydrogen concentration based on the detected transmitted light intensity in the overlap of the first measurement range and the second measurement range. | 2017-06-22 |
20170176404 | METHOD AND RELATIVE SYSTEM FOR THE DETECTION AND QUANTIFICATION OF THE H2S IN DRILLING MUD - Method for the detection and quantification of the H | 2017-06-22 |
20170176405 | METHOD AND MEASURING APPARATUS FOR DETERMINING PHYSICAL PROPERTIES OF GAS - A method to determine a physical property or a quantity of gas related to combustion including: flowing a gas from a reservoir through a critical nozzle and past a microthermal sensor wherein the mass flow of the gas through the critical nozzle is the same as the mass flow through the microthermal sensor; measuring the pressure drop in the reservoir as a function of time; deriving a first gas property factor based on a time constant of the pressure drop; determining a second gas property factor which depends from a flow signal generated by the microthermal sensor; determining a thermal conductivity of the gas; and determining the physical property or quantity based on a correlation between the physical property or quantity, and the first and/or second gas property factors and the thermal conductivity. | 2017-06-22 |
20170176406 | TEST-ELEMENT FOR A MOBILE WATER ANALYSIS ARRANGEMENT - A test element for a mobile water analyzing system includes a sample line and a key reagent disposed in the sample line. The sample line includes an inlet opening arranged at a first end, a pump port arranged at a second end of the sample line, an inlet section arranged between the inlet opening and the pump port, and a measuring section with at least one window arranged at an end of the measuring section. The inlet opening receives a water sample. The measuring section is arranged between the inlet section and the pump port and is coincident with a sample pathway. | 2017-06-22 |
20170176407 | SYSTEM AND PROCESS FOR JET FUEL EQUIPMENT AND PROCEDURE QUALITY CONTROL - The present invention is directed to a system and process for monitoring jet fuel quality control procedural compliance. One system of the current invention includes a portable computer in communication with a server over network, an equipment database, and a report module. In exemplary process, jet fuel equipment is input into the system and stored in the equipment database, along with the process for its inspection. Inspector profiles are input into the system. The system facilitates notification of required inspections for a facility. The system presents an interface guiding an inspector through inspection of jet fuel and jet fuel equipment inspections. The input is stored by the system, whereby the report module generate reports based on inspection reports, equipment, and facilities. | 2017-06-22 |
20170176408 | Detection of HIV-1-Associated Neurocognitive Disorders - Provided is a method of detecting mild neurocognitive disturbance (MNCD) or HIV associated dementia (HAD) in a patient comprising detecting the level of acetyl spermine and/or acetyl spermidine from a cerebrospinal fluid test sample of the patient; and comparing the level of acetyl spermine and/or acetyl spermidine in the test sample to the level of the acetyl spermine and/or acetyl spermidine in a cerebrospinal fluid control sample or to a control value for lack of neurocognitive impairment, MNCD or HAD; wherein an elevated level of acetyl spermine and/or acetyl spermidine in the test sample as compared to the level in the control sample or a control value for lack of neurocognitive impairment, or a level of acetyl spermine and/or acetyl spermidine that is similar to that of a control value for MNCD or HAD, indicates that the patient suffers from MNCD or HAD. Also provided are methods for measuring the progression of an HIV-1-associated neurocognitive disorder, as well as methods for staging such a disorder. | 2017-06-22 |
20170176409 | BIOLOGICAL SAMPLE MEASUREMENT DEVICE - A biological sample measurement device includes a biological sample measuring instrument and measurement-related information supply instrument which supplies measurement-related information. Measurement-related information supply instrument has reading unit which reads the measurement-related information, first storage unit which stores identification information of measurement-related information supply instrument, and transmission unit which transmits the measurement-related information and the identification information of measurement-related information supply instrument to the biological sample measuring instrument. The biological sample measuring instrument has a main body case which has a mounting portion of a biological sample detection sensor and a display unit, a measurement unit which is connected to the mounting portion inside the main body case, a control unit which is connected to the measurement unit, and a reception unit which is connected to the control unit and receives the measurement-related information and the identification information of the measurement-related information supply instrument transmitted from the transmission unit. | 2017-06-22 |
20170176410 | SYSTEMS AND METHODS FOR A VERSATILE ELECTROCHEMICAL TEST STRIP THAT MAY INCLUDE ONE OR MORE ASSAYS FOR DIFFERENT ANALYTES IN THE SAME TEST STRIP - A test strip for electrochemical testing of a blood analyte includes a plurality of test sites for the electrochemical testing of analytes on a single test strip. Each test site includes a first receiving port, the first receiving port for receiving a blood sample, the first receiving port at a first end of the test strip. The test site further includes a first electrode and a second electrode, the first and second electrodes proximate to the first receiving port. Each test site further includes a first contact and a second contact, the first and second contacts at a second end of the test strip, the first and second contacts interconnected with the first and second electrodes, respectively. | 2017-06-22 |
20170176411 | Chemical Impairment Detection System with an Integrated, Multi-Function Breath Chamber - A chemical impairment detection system adaptable for use in a vehicle. The impairment detection system includes an intake adapted to receive an air sample from a source and an alcohol sensor for detecting an alcohol level in the air sample. An integrated breath chamber channels the air sample from the intake to the alcohol sensor. Source evaluator means in the breath chamber measure one or more characteristics of the received air sample for validating the sample. The source evaluator means measures the air sample characteristics as the air sample flows through the breath chamber. | 2017-06-22 |
20170176412 | METHOD FOR PREDICTING OPTION OF DEPRESSION TREATMENT DRUG - A method for predicting options of depression treatment drugs includes (a) measuring a phosphoethanolamine (PEA) level in blood collected from a patient suspected of depression, (b) measuring whether the blood PEA level of the patient is lower than a reference value or not, wherein if the measured value of the patient is lower than values of healthy persons, the patient suffers from depression exhibiting a decreased PEA level as an indicator, and (c) predicting options of depression treatment drugs on the basis of the presence or absence of decreased blood PEA level in the patient. Thus, PEA, which is a biomarker of depression, can be directly linked to treatment. | 2017-06-22 |
20170176413 | PHARMACODYNAMIC ASSAYS - The present disclosure provides a method of monitoring total protein acetylation in a cell exposed to an HDAC inhibitor that involves first contacting a cell that has been exposed to an HDAC inhibitor with a plurality of reagents that each recognize and bind to a nuclear or cytoplasmic acetylated protein. The bound reagent is then detected using a detection assay and the level of the detected bound reagent is compared to a control, thereby monitoring total protein acetylation in the cell. | 2017-06-22 |
20170176414 | ELECTROCHEMICAL METHOD AND DEVICE FOR DETECTING THE EFFECT OF ANTICANCER DRUGS - An electrochemical method for detecting effect of an anticancer drug on cancer cells, including: culturing a plurality of cancer cells to form cultured cells, attaching the cultured cells onto an array of silicon nanowires (SiNWs) electrodes, measuring a first electrochemical response of the attached cells onto the array of electrodes, adding an anticancer drug to the attached cells onto the array of electrodes to form drug-treated cells, measuring a second electrochemical response of the drug-treated cells, and determining the effect of the anticancer drug on the cancer cells based on a comparison of the first and the second electrochemical responses. | 2017-06-22 |
20170176415 | DEVICE AND METHOD FOR FORCE PHENOTYPING OF CELLS FOR HIGH-THROUGHPUT SCREENING AND ANALYSIS - A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns. | 2017-06-22 |
20170176416 | METHODS FOR THE DETERMINATION OF COMPOUNDS OR COMPOSITIONS FOR THE TREATMENT OF LIPOFUSCIN RELATED DISEASES AND COMPOUNDS OR COMPOSITIONS - A method for selecting a compound or a composition suitable for treating lipofuscin associated diseases in a patient, the method including the steps of determining a reactivity factor, determining a targeting factor that allows an uptake into a cell and a provides a targeting of lipofuscin, and selecting a compound or a composition or combining compounds to obtain a compound or composition that comprises a reactivity factor and an targeting factor. | 2017-06-22 |
20170176417 | Method and Pharmaceutical Composition for Use in the Treatment of Neurodegenerative Disorders - The invention relates to compounds which activate the BASIGIN signalling pathway, preferably agonists of BASIGIN, for the treatment of neurodegenerative disorders. | 2017-06-22 |
20170176418 | DEVICE FOR DETECTION OF DISEASE STATES AND APPLICATIONS OF SAME - A device for testing a biological sample includes a test strip. The test strip includes a substrate having a first surface and an opposite, second surface; a first sample pad and a second sample pad disposed on the first surface and the second surface respectively, and configured to receive the biological sample; a first test pad disposed on the first surface, in contact with the first sample pad, and configured to test the biological sample received from the first sample pad; and a second test pad disposed on the second surface, in contact with the second sample pad, and configured to test the biological sample received from the second sample pad. The first and second sample pads may be configured to evaluate the CD44 protein and total protein of the sample, and used for early detection of neck squamous cell carcinoma (HNSCC). | 2017-06-22 |
20170176419 | LUMINESCENT OXYGEN CHANNELING IMMUNOASSAY UTILIZING THREE ANTIBODIES AND METHODS OF PRODUCTION AND USE THEREOF - A chemiluminescent detection system, as well as kits and microfluidics devices containing same, are disclosed. Methods of using the system, kits, and devices are also disclosed. The first, second, and third antibodies or binding fragments thereof may be provided in any form that allows these antibodies/binding fragments to function in accordance with the presently disclosed and claimed inventive concept(s). For example, each of the first, second, and third antibodies/binding fragments may be a polyclonal antibody/binding fragment or a monoclonal antibody/binding fragment. | 2017-06-22 |
20170176420 | SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS - The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation. | 2017-06-22 |
20170176421 | SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS - The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation. | 2017-06-22 |
20170176422 | Multiplexed Analyses of Test Samples - The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction. | 2017-06-22 |
20170176423 | MAGNETIC PROGRAMMABLE BEAD ENZYME-LINKED IMMUNOSORBENT ASSAY - Methods for making and using a programmable bead composition that in some embodiments includes a magnetic bead coupled to an antibody with DMTMM and an antigen coupled to the antibody, with the antigen having been expressed from a human cell lysate (FIG. | 2017-06-22 |
20170176424 | NANO-PILLAR-BASED BIOSENSING DEVICE - In one example, a device includes a trench formed in a substrate. The trench includes a first end and a second end that are non-collinear. A first plurality of semiconductor pillars is positioned near the first end of the trench and includes integrated light sources. A second plurality of semiconductor pillars is positioned near the second end of the trench and includes integrated photodetectors. | 2017-06-22 |
20170176425 | REAGENT CALIBRATION SYSTEM AND METHOD - One aspect relates to a method of calibrating event data. The method includes obtaining, via an electronic device including a processor, event data for an assay including a reagent. The reagent is associated with one of a plurality of manufacturing lots of the reagent. The method includes receiving one or more calibration factors for the reagent based on an identifier associated with the one of the plurality of manufacturing lots. The method further includes generating calibrated event data based on an application of the one or more calibration factors to the event data. | 2017-06-22 |
20170176426 | MICROORGANISM CONCENTRATION PROCESS - A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration agent. | 2017-06-22 |
20170176427 | Bifunctional Acid Monolayers for the Selective Placement of Carbon Nanotubes - Techniques for selective placement of carbon nanotubes using bifunctional acid monolayers are provided. In one aspect, a method for selective placement of carbon nanotubes on a metal oxide surface includes the steps of: dispersing poly-fluorene polymer-wrapped carbon nanotubes in an organic solvent; creating a patterned monolayer of a bifunctional acid on the metal oxide surface, wherein the bifunctional acid comprises a first acid functional group for binding to the metal oxide surface, and a second acid functional group for binding to the poly-fluorene polymer-wrapped carbon nanotubes; and contacting the poly-fluorene polymer-wrapped carbon nanotubes dispersed in the organic solvent with the patterned monolayer of the bifunctional acid on the metal oxide surface to selectively place the carbon nanotubes on the metal oxide surface via the patterned monolayer of the bifunctional acid. A carbon nanotube-based device and method of formation thereof are also provided. | 2017-06-22 |
20170176428 | SHAPED ARTICLES INCLUDING HYDROGELS AND METHODS OF MANUFACTURE AND USE THEREOF - The invention features shaped articles containing a structure and a hydrogel coating thereon, the hydrogel coating containing alginic acid conjugated to a polyalkylene oxide and a binding moiety. The hydrogel coating on the structure is sized and shaped to fit in a well in a microtiter plate and the coating does not cover the entire exterior of the surface. The invention further features methods of capturing targets using shaped articles and methods of preparing shaped articles. | 2017-06-22 |
20170176429 | SANDWICH ASSAYS IN DROPLETS - The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte. | 2017-06-22 |
20170176430 | SUBSTANCE SEALING METHOD AND TARGET MOLECULE DETECTING METHOD - As a technique for efficiently sealing many substances, such as beads, nucleic acid, protein, virus, cells, and lipid membrane complex, into an array, the present invention provides a method for sealing a substance, including: (i) a step of introducing a first solvent containing a substance on a substrate on which a plurality of receptacles capable of storing the substance are formed separated from each other by a side wall; and (ii) a step of introducing a second solvent having a greater specific gravity than that of the first solvent onto the first solvent, the step (ii) being carried out after the step (i). | 2017-06-22 |
20170176431 | THERMAL TRANSFER MEDIUM FOR TESTING DEVICE, TESTING DEVICE AND METHOD FOR PRODUCING SAME, AND TESTING KIT - Provided is a thermal transfer medium for a testing device, the thermal transfer medium including a support, a solid-phase reagent layer provided over the support and containing a reagent over a surface of the solid-phase reagent layer; and a protective layer provided over the solid-phase reagent layer in a manner to cover the reagent, wherein an average thickness of the protective layer is 0.5 μm or greater but 30 μm or less. | 2017-06-22 |
20170176432 | AUTOANTIBODY DETECTION METHOD, METHOD FOR TESTING POSSIBILITY OF AUTOIMMUNE DISEASE CONTRACTION, AUTOANTIBODY DETECTION REAGENT, AND AUTOIMMUNE DISEASE TEST REAGENT - The present invention provides an autoantibody detection method that can detect an autoantibody causing an autoimmune disease with high accuracy. The autoantibody detection method of the present invention includes the steps of; causing a sample and an antigen reagent comprising a denatured protein presented by an MHC class II molecule to come into contact with each other; and detecting a complex of an autoantibody in the sample and the denatured protein in the antigen reagent. By detecting a complex of the autoantibody and the denatured protein in a biological specimen isolated from a subject according to this detection method, it is possible to test the possibility of the autoimmune disease in the subject from the detection result. | 2017-06-22 |
20170176433 | ASSAYS FOR DETECTING NEUTRALIZING AUTOANTIBODIES TO BIOLOGIC THERAPY - The present invention provides assays for detecting and measuring the presence or level of neutralizing and non-neutralizing autoantibodies to biologics such as anti-TNFα drug therapeutics in a sample. The present invention is useful for monitoring the formation of neutralizing and/or non-neutralizing anti-drug antibodies over time while a subject is on biologic therapy. The present invention is also useful for predicting and/or determining the cross-reactivity of neutralizing anti-drug antibodies in a subject's sample with alternative biologic therapies. As such, the present invention provides information for guiding treatment decisions for those subjects receiving therapy with a biologic agent and improves the accuracy of optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment to biologic therapy. | 2017-06-22 |
20170176434 | METHODS AND COMPOSITIONS FOR THE PREDICTION AND TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS - Provided herein are methods and compositions for the prediction and treatment of focal segmental glomerulosclerosis and other proteinuric renal diseases such as native FSGS, minimal change disease, glomerular nephritis, membrano-proliferative glomerular nephritis (membranous), or IgA glomerular nephritis (membranous). | 2017-06-22 |
20170176435 | CELLULAR PLATFORM FOR RAPID AND COMPREHENSIVE T-CELL IMMUNOMONITORING - Methods and systems for the efficient and systematic identification of the repertoire of T-cell epitopes. | 2017-06-22 |
20170176436 | METHODS (AMACR) - A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein. | 2017-06-22 |
20170176437 | Method of diagnosing and monitoring bladder cancer and melanoma - The present invention provides a method for the diagnosing and monitoring of melanoma | 2017-06-22 |
20170176438 | Method of Detecting Cancer - The disclosure provides methods for resolving an inconclusive cytological assessment of clinically relevant cells in a sample obtained from a patient based on the cytological detection of antibody binding to telomerase in clinically relevant cells in the sample, wherein binding of the antibody to clinically relevant cells indicates the presence of malignant or cancerous cells. | 2017-06-22 |
20170176439 | MARKERS AND THERAPEUTIC INDICATORS FOR GLIOBLASTOMA MULTIFORME (GBM) - A signature of proteins occurring in glioblastoma multiforme (GBM) tissue comprised of 33 cell surface proteins (GBMSig) that distinguish subjects with GBM from healthy controls with more than 98% accuracy is described. In addition, four of the members of this signature are particularly useful as blood-borne markers of GBM. Certain other members of the signature are indicators of the possible efficacy of the use of TGF-β1 inhibitors in the treatment of this condition. Methods to treat and to stratify GBM based on GBMSig proteins are also disclosed. | 2017-06-22 |
20170176440 | METHODS AND COMPOSITIONS FOR EVALUATING BREAST CANCER PATIENTS - Embodiments are directed to methods of evaluating the prognosis of a breast cancer patient by assessing the level of phosphorylation tyrosine 36 of estrogen receptor beta (ERB). Certain embodiments are directed to methods for evaluating the prognosis of a cancer patient comprising contacting a breast cancer sample from a patient with stage II or stage III breast cancer with an antibody that binds phosphorylated tyrosine 36 of Ei¾β; quantifying phosphorylation of tyrosine 36 of EI¾β; and classifying the patient as having a good prognosis if phosphorylated tyrosine 36 levels are elevated or classifying the patient as having a poor prognosis if tyrosine levels are decreased relative to a non-cancer control. Certain embodiments are directed to an antibody or antibodies that specifically bind tyrosine 36 (Y36) of the ERp. | 2017-06-22 |
20170176441 | PROTEIN BIOMARKER PROFILES FOR DETECTING COLORECTAL TUMORS - Disclosed herein are panels related to the diagnosis or recognition of colon and colorectal cancer in a subject. The disclosed panels and related methods are used to predict or assess colon tumor status in a patient. They can be used to determine nature of tumor, recurrence, or patient response to treatments. Some embodiments of the methods include generating a report for clinical management. | 2017-06-22 |
20170176442 | METHOD OF DETECTION OF PROTEOLYSIS PRODUCTS IN PLASMA AND A DIAGNOSTIC SYSTEM FOR ITS APPLICATION - The present invention relates to the fields of medicine and immunology. In particular, this invention relates to immunological diagnostic methods that use the whole-length molecule of plasminogen or its peptide fragments as universal detectors of proteolysis products having a C-terminal lysine. The method of this immunological diagnostic is to identify the human diseases associated with increased activity of proteolytic enzymes. The inventions also relate to a diagnostic test system comprised of a detector—the full-length molecule and its presented peptide fragments. The technical result is comprised of achieving the required degree of dissociation of the antigen-antibody complex in a sample from the subject, as well as changing the conformation of proteins using an incubation buffer containing organic solvents in the disclosed ratios, that can significantly increase the sensitivity of the method for determining the concentration of proteolytic fragments with a C-terminal lysine binding with plasminogen or fragments thereof. | 2017-06-22 |
20170176443 | METHOD FOR DETECTING OR MONITORING PROSTATE CANCER - The present invention provides methods identifying subjects having prostate cancer (PCa) by detecting in microparticles a pair of biomarkers. The methods disclosed can be used to distinguish subjects having PCa from those having non-malignant prostate pathologies, including benign prostatic hyperplasia. Methods for monitoring prostate cancer and assessing efficacy of prostate cancer therapies are also disclosed. Kits for detecting prostate cancer using the methods disclosed are also provided. | 2017-06-22 |
20170176444 | DIAGNOSIS OF CANCER BY DETECTING AUTO-ANTIBODIES AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR (VEGFR) - The present invention relates to a method for diagnosis of a cancer, comprising the steps of (i) determining the level of antibodies against vascular endothelial growth factor receptor (VEGFR) in a sample from a subject to be diagnosed, (ii) comparing the determined level in the sample to a control level derived from subjects without cancer; wherein a decreased level in the sample from the subject to be diagnosed as compared to the control level is indicative for cancer in the subject. Furthermore, the invention relates to method of predicting response and outcome of a treatment of a cancer with an angiogenesis inhibitor. | 2017-06-22 |
20170176445 | METHOD FOR DETERMINING THE LEVEL OF HYPOXIA IN A TUMOR - The invention is in the field of medicine and molecular therapeutics. The invention provides means and measures for diagnosis and treatment, in particular for diagnosis and treatment of tumors, more in particular for determining the level of hypoxia in a tumor and for reducing the risk of metastasis of a tumor in a subject. The invention comprises a method wherein a level of exosome-associated GABARAPL1 is determined in a bodily fluid of the subject and wherein an elevated level of exosome-associated GABARAPL1 is indicative of an increased level of hypoxia of the tumor. The invention also comprises an antibody directed against GABARAPL1 for use in the treatment or prevention of cancer. | 2017-06-22 |
20170176446 | Methods for Determining the Oncogenic Condition of Cell, Uses Thereof, and Methods for Treating Cancer - The invention relates to methods for detecting the oncogenic condition of cells, including step where the amount of the OCDO compound in said cells is measured, and to the uses thereof. The invention further relates to OCDO inhibitors for use in methods for treating cancer. | 2017-06-22 |
20170176447 | METHOD AND APPARATUS FOR ANALYZING ACETONE IN BREATH - Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level. The method also comprises using the breath analysis device to detect the change in the optical characteristic to sense the acetone in the breath. Apparatuses that use these methods are also described. | 2017-06-22 |
20170176448 | Health And Wellness Testing Kit For Home Use - The present invention relates to a health and wellness testing and lifestyle adjustment advice kit, and the like, and more particularly to a health and wellness testing kit for home use with accompanying instructions for testing results interpretation and lifestyle adjustment thereafter. Embodiments of the kit include pH testing materials and glucose testing materials for analyzing a user's urine sample, and informational and advice material (both written and on digital video) for reaching optimum urine pH values and glucose values. | 2017-06-22 |
20170176449 | MICROFLUIDIC ARRAY SUPPORTING A LIPID BILAYER ASSEMBLY - A microfluidic array supporting a lipid bilayer assembly on which membrane proteins can be assembled is described. | 2017-06-22 |
20170176450 | SYSTEMS AND METHODS FOR IDENTIFYING PROTEIN STABILIZERS - A device for studying protein conformation transformation can include a macroscopic substrate, and chaperonin proteins bound to the substrate, each chaperonin protein being capable of binding to a protein of interest during or after undergoing protein conformation transformation. The device may also include the proteins of interest bound to the substrate, where the substrate is included in a label-free assay system. A method of studying protein conformation transformation can include: providing a macroscopic substrate bound with the chaperonin protein and immersing the chaperonin protein in a study composition having the protein of interest, or include providing a macroscopic substrate bound with the protein of interest; and immersing the protein in a study composition having the chaperonin. Such a method can be done with and without a potential stabilizer in order to determine whether the potential stabilizer stabilizes the protein of interest. | 2017-06-22 |
20170176451 | KISSPEPTIN-54 DETECTION BY TANDEM MASS SPECTROMETRY - Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques. | 2017-06-22 |
20170176452 | THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY - Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample. | 2017-06-22 |
20170176453 | MICROARRAY COMPOSITIONS AND METHODS OF THEIR USE - Microarray compositions suitable for analysis by one or several spectrographic methods are disclosed. In an embodiment, a microarray composition includes a three-dimensional solid support and a plurality of reactive microbeads positioned on the solid support in spatially distinct and addressable locations. | 2017-06-22 |
20170176454 | IMPROVED ANTI-NUCLEAR ANTIBODY DETECTION AND DIAGNOSTICS FOR SYSTEMIC AND NON-SYSTEMIC AUTOIMMUNE DISORDERS - Provided are compositions that contain mammalian cells for use in detecting antibodies. The mammalian cells are modified such that they do not contain LEDGF protein. The mammalian cells are immobilized on a solid substrate. The compositions can also contain mammalian cells that contain the LEDGF protein. Methods for using the cell compositions in diagnostic approaches are included, as are kits for performing diagnostic tests. | 2017-06-22 |
20170176455 | Methods of Detecting and Preventing Atopic Allergic Diseases - The present invention is related to novel methods for identifying a population of subjects that are at risk for developing of atopic allergic diseases, and to the prevention of these allergic diseases. | 2017-06-22 |
20170176456 | BIOLOGICAL MARKER FOR EVALUATING THE IL-17 PRO-INFLAMMATORY FUNCTIONAL CONTRIBUTION DEPENDENT LEVEL IN AN INDIVIDUAL - The invention relates to an in vitro process for determining the functional IL-17 pro-inflammatory dependent level (IPDL) of a biological sample, comprising the following steps:
| 2017-06-22 |
20170176457 | COMPOSITIONS AND METHODS FOR TREATING EYE INFECTIONS AND DISEASE - The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but no normal tears. | 2017-06-22 |
20170176458 | Fibrosis Biomarker Assay - Methods of diagnosis or of quantitation of fibrosis are provided that comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of the measure in the patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a contacting protein fragments naturally present in the sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to the immunological binding partner to measure therein protein fragments comprising the neo-epitope. The protein is collagen type I, collagen type IV, collagen type V, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein. | 2017-06-22 |
20170176459 | NEUROTOXICITY BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ACUTE TRAUMATIC BRAIN AND SPINAL CORD INJURY - Provided herein are compositions, methods and kits for determining the level of an AMPAR/KAR peptides in a subject. The methods include obtaining a biological sample from the subject and determining a level of one or more AMPAR/KAR peptides selected from the group consisting of GluR1/GluR6_7, GluR2/GluR6_7, GluR3/GluR6_7, GluR1/GluR6, GluR2/GluR7, and any combination thereof in the biological sample. | 2017-06-22 |
20170176460 | NEURAL SPECIFIC S100-BETA FOR BIOMARKER ASSAYS AND DEVICES FOR DETECTION OF A NEUROLOGICAL CONDITION - An in vitro diagnostic (IVD) device is used to detect the presence of and/or severity of neural injuries or neuronal disorders in a subject. The IVD device relies on an immunoassay which identifies biomarkers that are diagnostic of neural injury and/or neuronal disorders in a biological sample, such as whole blood, plasma, serum, and/or cerebrospinal fluid (CSF). An IVD device may measure one or more of several neural specific markers in a biological sample and output the results to a machine readable format, either to a display device or to a storage device internal or external to the IVD. | 2017-06-22 |
20170176461 | SYSTEMS AND METHODS FOR QUANTIFICATION OF CREATININE USING A CREATININE-PROTEIN CONJUGATE - A system for determining a level of creatinine in a sample includes a test strip system configured to receive a sample, the test strip system including a first lateral flow test strip and a meter configured to receive the test strip, wherein the meter is configured to read the test strip and detect a level of creatinine, wherein the first lateral flow test strip includes microparticles combined with a creatinine antibody. | 2017-06-22 |
20170176462 | MULTIPLEX IMMUNOASSAYS FOR HEMOGLOBIN, HEMOGLOBIN VARIANTS, AND GLYCATED FORMS - Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided. | 2017-06-22 |