25th week of 2017 patent applcation highlights part 32 |
Patent application number | Title | Published |
20170175156 | In vitro method for fast scarless DNA assembly using thermostable exonucleases and ligase - The present invention provides a method for scarless in vitro DNA assembly using thermostable exonucleases and ligase, which relates to the field of genetic engineering. The present invention provides a fast method for assembling DNA subfragments with homologous ends, which employs thermostable polymerases and ligase in a thermal cycle of denaturation, annealing, digestion and ligation. After denaturation, DNA subfragments are assembled together via annealing of the homologous end sequences, the unpaired single-stranded overhangs are digested by polymerases, and the resulting nicked gaps are sealed by a ligase. Using this method, 2-6 DNA subfragments were successfully assembled within two hours. This method can be used in conventional DNA recombination and be adapted to high throughput assembly operations. In addition, combinatorial mutations can be easily introduced into the assembled sequence by use of primers with mutated bases. It is particularly suitable for making enzyme and synthetic pathways mutation libraries with high diversity, which can be used in directed evolution to screen for enzymes and synthetic pathways with desirable properties. | 2017-06-22 |
20170175157 | METHODS AND COMPOSITIONS FOR EXPRESSION CASSETTES WITH SUBSTITUTED ELEMENTS FOR ENHANCED EXPRESSION - In one aspect, the present invention provides an expression cassette comprising a promoter operably linked to a nucleic acid molecule of interest, which is operably linked to a terminator, further comprising a heterologous intron that enhances expression of the nucleic acid molecule of interest, wherein the heterologous intron is selected from the group comprised of SEQUENCE ID NO. 1 (iZm10430-02), SEQUENCE ID NO. 2 (iZm10430-01) SEQUENCE ID NO. 3 (iZm008975-01), SEQUENCE ID NO. 4 (iZm005854-01), SEQUENCE ID NO. 5 (iZm010719-01), and SEQUENCE ID NO. 6 (iZm007840-01). In another aspect, the present invention provides an expression cassette comprising a promoter operably linked to a nucleic acid molecule of interest, which is operably linked to a heterologous terminator that enhances expression of the nucleic acid molecule of interest, wherein the heterologous terminator is selected from the group of SEQUENCE ID NO. 7 (tZmHSP70-01), SEQUENCE ID NO. 8 (tZmUbi158-01), SEQUENCE ID NO. 9 (tZmUbi1-01), SEQUENCE ID NO. 10 (tZmUbi361-01). | 2017-06-22 |
20170175158 | AgsE-DEFICIENT STRAIN - The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions. | 2017-06-22 |
20170175159 | METHOD FOR PRODUCING A MINOR GINSENOSIDE USING A GINSENOSIDE GLYCOSIDASE - Provided are a method of producing minor ginsenosides using a ginsenoside glycosidase protein derived from a | 2017-06-22 |
20170175160 | Electrophysiological assays using oocytes that express human enac and the use of phenamil to improve the effect of enac enhancers in assays using membrane potential reporting dyes - In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil. In the case of the inventive oocyte electrophysiological assays (two-electrode voltage-clamp technique), these assays facilitate the identification of compounds which specifically modulate human ENaC. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit hENaC function. Compounds that enhance or block human ENaC channel activity should therebymodulate salty taste in humans. | 2017-06-22 |
20170175161 | RAPID DETERMINATION OF BACTERIAL SUSCEPTIBILITY TO AN ANTIBIOTIC AT THE POINT OF CARE - A method for determining whether bacteria in a sample obtained from a subject at a point of care in a clinical setting is susceptible to an antibiotic, within a time period associated with a point of care. The method includes measuring a bioluminescent indication from a first test sample based on released ATP to determine a characteristic associated with the bioluminescent indication and comparing the characteristic associated with the bioluminescent indication to a first threshold. The method includes determining whether a bacteria is present by comparing the difference between a characteristic associated with a first confirmatory bioluminescent signal and a characteristic associated with a second confirmatory bioluminescent signal to an confirmatory threshold. The method includes determining that bacteria is susceptible to an antibiotic by comparing a difference between a characteristic associated with a second bioluminescent signal and a characteristic associated with the first bioluminescent signal to a second threshold. | 2017-06-22 |
20170175162 | METHOD FOR DETECTING A PLASMODIUM INFECTION - The invention relates to a method for detecting a | 2017-06-22 |
20170175163 | WASH MONITOR COMPOSITION, DEVICE, AND METHOD OF USE - A composition for monitoring the efficacy of a decontamination process is provided, the composition comprising a cellulose polymer and a predetermined quantity of an adenine nucleotide. A monitoring device comprising a test element with the composition disposed thereon is also provided. The composition and/or monitoring device can be used in a method. The method includes exposing the monitoring device to a decontamination process and subsequently measuring the residual tracer analyte on the monitoring device. | 2017-06-22 |
20170175164 | L-2-HYDROXYGLUTARATE AND STRESS INDUCED METABOLISM - The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro. | 2017-06-22 |
20170175165 | DETECTION OF STARCH LEVELS IN BIOLOGICAL MATRICES - The present application is directed to methods for the detection of a starch in a sample. The methods comprise the steps of initially incubating the sample in the presence of an amylase and subsequently subjecting the sample to liquid chromatography mass spectrometry (LC-MS) to detect ions characteristic of the starch in the sample. | 2017-06-22 |
20170175166 | ACETAMINOPHEN ADDUCTS AND METHODS OF USE THEREOF - The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP-protein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine 5-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin. | 2017-06-22 |
20170175167 | COMPOSITION FOR DIAGNOSING CANCER USING PKA ACTIVITY AND INFORMATION PROVIDING METHOD FOR DIAGNOSING METASTASIS - Disclosed is a composition for diagnosing cancer, including an agent for measuring PKA (Protein Kinase A) activity. | 2017-06-22 |
20170175168 | RAPID, LOW-SAMPLE-VOLUME CHOLESTEROL AND TRIGLYCERIDE ASSAYS - Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed. Assays may be performed in a single reaction mixture, allowing more accurate and precise cholesterol determinations, including ratios of cholesterol sub-fractions to total cholesterol, at less expense, than would be expected by performing several different assays in different reaction mixtures. | 2017-06-22 |
20170175169 | CLINICAL DECISION SUPPORT SYSTEM UTILIZING DEEP NEURAL NETWORKS FOR DIAGNOSIS OF CHRONIC DISEASES - The inventors have developed a clinical decision support system (“CDSS”) and associated devices to diagnose chronic diseases in patients using a large number of biomarkers. The inventors have utilized a process for identifying thousands of biomarkers that could be relevant to potential diseases. Once these biomarkers are identified, the ones that have the most affinity for relevant biomarkers are retained. Then, a clinical decision support system can utilize the thousands of biomarkers, and apply a DNN based machine learning algorithm to diagnose chronic diseases. | 2017-06-22 |
20170175170 | HIGH-LEVEL MULTIPLEX AMPLIFICATION - The present disclosure provides a “looping amplification” method to increase the specificity of nucleic acid amplification. This increased specificity facilitates multiplexing to a much higher degree than was previously possible. | 2017-06-22 |
20170175171 | METHODS AND KITS FOR BREAKING EMULSIONS - The disclosure relates generally to methods, kits and systems for extracting biomolecules from a water-in-oil emulsion, including breaking a water-in-oil emulsion comprising a plurality of aqueous droplets in a continuous hydrophobic fraction using a breaking solution to produce a resulting reaction mixture containing one or more biomolecules and manipulating the resulting reaction mixture to form at least two phases, where one of the phases includes an aqueous phase containing the one or more biomolecules. | 2017-06-22 |
20170175172 | METHOD AND SYSTEM FOR CHARACTERIZING MOUTH-ASSOCIATED CONDITIONS - Embodiments of a system and method for characterizing a mouth-associated condition in relation to a user can include one or more of: a handling network operable to collect containers including material from a set of users, the handling network including a sequencing system operable to determine microorganism sequences from sequencing the material; a microbiome characterization system operable to determine microbiome composition data and microbiome functional diversity data based on the microorganism sequences, collect supplementary data associated with the mouth-associated condition for the set of users, and transform the supplementary data and features extracted from the microbiome composition data and the microbiome functional diversity data into a characterization model for the mouth-associated condition; and/or a therapy system operable to promote a treatment to the user based on characterizing the user with the characterization model in relation to the mouth-associated condition. | 2017-06-22 |
20170175173 | DNA Glycosylase/Lyase and AP Endonuclease Substrates - A new class of nucleic acid substrates for AP endonucleases and members of the glycosylase/lyase family of enzymes is described. Representatives of each family, the enzymes Nfo and fpg, respectively, cleave nucleic acid backbones at positions in which a base has been replaced by a linker to which a variety of label moieties may be attached. The use of these synthetic substrates embedded within oligonucleotides is of utility in a number of applications. | 2017-06-22 |
20170175174 | METHODS AND APPARATUS FOR PERFORMING DIGITAL ASSAYS USING POLYDISPERSE DROPLETS - Methods, devices, and systems for performing digital assays are provided. In certain aspects, the methods, devices, and systems can be used for the amplification and detection of nucleic acids. In certain aspects, the methods, devices, and systems can be used for the recognition, detection, and sizing of droplets in a volume. Also provided are compositions and kits suitable for use with the methods and devices of the present disclosure. | 2017-06-22 |
20170175175 | SYSTEMS AND METHODS FOR MULTIPLEX ANALYSIS OF PCR IN REAL TIME - The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process. | 2017-06-22 |
20170175176 | THREE-DIMENSIONAL POLYMER NETWORKS WITH CHANNELS SITUATED THEREIN - The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays. | 2017-06-22 |
20170175177 | METHOD FOR DETECTING NUCLEIC ACID, CAPTURE PROBE, DETECTION PROBE SET, MICROARRAY, NUCLEIC ACID DETECTION KIT, NUCLEIC-ACID-IMMOBILIZED SOLID PHASE, AND FLUID DEVICE - A method for detecting a nucleic acid includes (a) bringing a solution including a nucleic acid and a detection probe labeled with a labeling substance into contact with a solid phase on which a capture probe is immobilized, the capture probe having a first portion including a sequence capable of hybridizing with the nucleic acid, a second portion including a sequence capable of hybridizing with the detection probe, and a stem portion for forming a double strand; (b) hybridizing the nucleic acid with the first portion, hybridizing the detection probe with the second portion, and forming a nucleic acid-detection probe-capture probe complex on the solid phase; (c) ligating the nucleic acid and the detection probe; (d) eliminating binding between the capture probe and the detection probe that has not been ligated with the nucleic acid; and (e) detecting the labeling substance in the complex. | 2017-06-22 |
20170175178 | CHROMOGENIC PEROXIDASE SUBSTRATES - Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color. | 2017-06-22 |
20170175179 | EMULSION CHEMISTRY FOR ENCAPSULATED DROPLETS - System, including methods, apparatus, compositions, and kits, for making and using a stabilized emulsion. A method of generating a stabilized emulsion is provided. In the method, an aqueous phase may be provided. The aqueous phase may include an effective concentration of one or more skin-forming proteins. An emulsion may be formed. The emulsion may include droplets of a dispersed phase disposed in a continuous phase, with the aqueous phase being the continuous phase or the dispersed phase. The emulsion may be heated to create an interfacial skin between each droplet and the continuous phase, to transform the droplets into capsules. | 2017-06-22 |
20170175180 | AMPLIFICATION AND DETECTION OF RIBONUCLEIC ACIDS - Compositions, methods, and kits for detecting one or more species of RNA molecules are disclosed. In one embodiment, a first adaptor and a second adaptor are ligated to the RNA molecule using a polypeptide comprising double-strand specific RNA ligase activity, without an intervening purification step. The ligated product is reverse transcribed, then at least some of the ribonucleosides in the reverse transcription product are removed. Primers are added and amplified products are generated. In certain embodiments, the sequence of at least part of at least one species of amplified product is determined and at least part of the corresponding RNA molecule is determined. In some embodiments, at least some of the amplified product species are detected, directly or indirectly, allowing the presence and/or quantity of the RNA molecule of interest to be determined. | 2017-06-22 |
20170175181 | NANOFLUIDIC DEVICES FOR THE RAPID MAPPING OF WHOLE GENOMES AND RELATED SYSTEMS AND METHODS OF ANALYSIS - Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule. | 2017-06-22 |
20170175182 | TRANSPOSASE-MEDIATED BARCODING OF FRAGMENTED DNA - Provided herein, among other things, are a variety of methods that comprise inserting a plurality of barcoded transposons into a population of DNA fragments that comprise DNA fragments of less than 1 kb in length, to produce transposon-tagged fragments that each comprise a barcoded transposon. Kits for performing this method are also provided. | 2017-06-22 |
20170175183 | PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS - The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods. | 2017-06-22 |
20170175184 | DNA SEQUENCING FROM HIGH DENSITY DNA ARRAYS USING ASYNCHRONOUS REACTIONS - The invention relates to an automated method for high-throughput DNA sequencing from high density DNA arrays by (a) initiating a first sequencing reaction on a first high density DNA array; and imaging said first high density DNA array using a detector, and (b) initiating a first sequencing reaction on a second high density DNA array; and imaging said second high density DNA array using the detector, wherein the first sequencing reaction in (a) is initiated before the first sequencing reaction in (b) is initiated such that the sequencing reactions in (a) and (b) are staggered. By using asynchronous sequencing reactions and imaging two separate arrays using one detector, imaging can be carried out on one array while sequencing reactions are carried out on one the other, substrate, the other substrate is imaged, reducing the idle time of the imaging system. | 2017-06-22 |
20170175185 | NANOWIRE-BASED SYSTEM FOR ANALYSIS OF NUCLEIC ACIDS - A method for sequencing a nucleic acid template includes forming a nanowire assembly including a semiconductor nanowire and a probe covalently bound to the semiconductor nanowire; contacting the nanowire assembly with a template nucleic acid; contacting the nucleic acid duplexes with an extension nucleic acid, the extension nucleic acid joined to the probe; disrupting the nucleic acid duplexes; and measuring an electrical characteristic of a nanowire assembly of the set of nanowire assemblies. | 2017-06-22 |
20170175186 | EFFICIENT OPTICAL ANALYSIS OF POLYMERS USING ARRAYS OF NANOSTRUCTURES - The invention is directed to methods and apparatus for detecting sequences of optical signals from parallel reactions on an array of nanostructures, such as nanopores, nanowells, or nanoparticles. In accordance with the invention, an array of nanostructures is provided, each nanostructure comprising a reaction site and each capable of confining a reaction that generates a sequence of optical signals, and the nanostructures of the array being arranged in clusters each comprising a number of nanostructures. Each different cluster is disposed within a different resolution limited area and the number of nanostructures in each cluster is either greater than one or a random variable with an average value greater than zero. Optical signals from reactions in the nanostructures are detected by an optical system operatively associated with the array. | 2017-06-22 |
20170175187 | SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA AND DETERMINING CHROMOSOME COPY NUMBER - Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents. | 2017-06-22 |
20170175189 | DIAGNOSIS AND PREDICTION OF AUSTISM SPECTRAL DISORDER - Methods and compositions for the detection of single nucleotide polymorphisms (SNP) to determine whether the subject has autism spectrum disorder (ASD), is likely to develop ASD, or to classify a subject as having a particular ASD subtype. The presence and/or absence of the one or more SNPs is compared to the presence and/or absence of the SNPs in at least one sample training set(s), where the comparing step comprises applying a statistical algorithm which comprises determining a correlation between the SNP data obtained from the sample and the SNP data from the at least one training set. | 2017-06-22 |
20170175190 | Circulating microRNA as Biomarkers for Endometriosis - The invention includes compositions and methods useful for the diagnosis, assessment, and characterization of endometriosis in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with endometriosis. | 2017-06-22 |
20170175191 | METHOD FOR THE DIAGNOSIS AND/OR PROGNOSIS OF ACUTE RENAL DAMAGE - The invention relates to miRNAs: miR-26b, miR-29a, miR-454, miR-146a, miR-27a, mi-R93 and miR-10a, as markers of acute renal damage, and to a method and kit for the diagnosis and/or prognosis of acute renal damage using said markers. | 2017-06-22 |
20170175192 | DETERMINATION OF MIR-423-5P IN HEART FAILURE - The present invention relates to methods, kits and uses for diagnosing heart failure using miRNA-biomarker from blood. | 2017-06-22 |
20170175193 | Improved Therapeutic Regimen for Hypertension - The invention relates to improved methods, devices, and kits for identifying and implementing an appropriate treatment regimen for subjects suffering from hypertension. | 2017-06-22 |
20170175194 | UV Associated mtDNA Fusion Transcripts and Methods and Uses Thereof - The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products. | 2017-06-22 |
20170175195 | METHODS FOR ASSESSING LIVER PATHOLOGIES - The present invention provides a new method for detecting or monitoring a liver disease in a subject that has no indication of any liver pathologies, by measuring the amount of concentration of albumin mRNA in an acellular blood sample from the subject, and then comparing the amount or concentration of albumin mRNA with a standard control. | 2017-06-22 |
20170175196 | DIAGNOSIS OF HEREDITARY SPASTIC PARAPLEGIAS (HSP) BY DETECTION OF A MUTATION IN THE KIAA1840 GENE OR PROTEIN - An ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP) in a subject is provided which comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein that mutation is indicative of an hereditary spastic paraplegias (HSP). | 2017-06-22 |
20170175197 | MOLECULAR PROFILING OF IMMUNE MODULATORS - Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for the disease, such as treatments that provide likely benefit or likely lack of benefit for the disease. The molecular profiling can include analysis of immune modulators such as PD-1 and/or its ligand PD-L1. | 2017-06-22 |
20170175198 | DISCRIMINATING BRAF MUTATIONS - Provided herein are methods for detecting and discriminating BRAF V600 mutations. Also provided herein are methods for diagnosis, prognosis, management, and treatment decisions of BRAF V600 mutation-related diseases or conditions. | 2017-06-22 |
20170175199 | Immune Gene Signatures in Urothelial Carcinoma (UC) - This invention relates to methods for selecting a treatment, treating, and predicting survival time in subjects with cancer, such as colorectal cancer, based on tumor expression levels of chemokines, cytotoxic genes, and/or dendritic cell genes. | 2017-06-22 |
20170175200 | USE OF DOUBLE-STRANDED DNA IN EXOSOMES: A NOVEL BIOMARKER IN CANCER DETECTION - The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double-stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information. | 2017-06-22 |
20170175201 | THE TGF(Beta)-MIR200-MIG6 PATHWAY AND ITS USE IN THE TREATMENT OF CANCER AS AN INDICATOR OF RESISTANCE TO EGFR INHIBITORS - The present invention provides methods for identifying the susceptibility of a cancer cell or population of cells to treatment with Epidermal Growth Factor (EGF) Tyrosine Kinase Inhibitors (TKIs), such as erlotinib. Methods for the in vitro diagnosis of the susceptibility of a tumor in a subject to treatment with TKIs and monitoring tumor susceptibility during treatment are also provided. | 2017-06-22 |
20170175202 | CENTROMERE/KINETOCHORE PROTEIN GENES FOR CANCER DIAGNOSIS, PROGNOSIS AND TREATMENT SELECTION - The invention described in the application relates to a panel of gene expression markers for patient with a tumor. The invention thus provides methods and compositions, e.g., kits, for evaluating gene expression levels of the markers and methods of using such gene expression levels to evaluate the likelihood of disease progression or response to chemotherapy or radiation therapy. Such information can be usd in determining prognosis and treatment options for cancer patients. | 2017-06-22 |
20170175203 | EVALUATION METHOD FOR EVALUATING THE LIKELIHOOD OF BREAST CANCER - The invention relates to a method for evaluating the likelihood of a person having breast cancer, the method including detecting and quantifying specific microRNAs in serum or plasma, the expression of which is related to the presence of a breast tumour. The invention also relates to the use of specific microRNAs, the expression of which is related to the presence of a breast tumour. | 2017-06-22 |
20170175204 | METHODS AND DEVICES FOR PREDICTING ANTHRACYCLINE TREATMENT EFFICACY - The invention features methods, devices, and kits for predicting the responsiveness of a cancer patient (e.g., a breast cancer patient, such as a grade 1, 2, or 3 breast cancer patient) to anthracycline treatment by determining the expression levels of four chromosomal instability (CIN) genes including HDGF, KIAA0286, RFC4, and MSH6, collectively referred to as CIN4. Patients that have a low CIN4 score benefit from anthracycline treatment compared patients with a high CIN4 score. | 2017-06-22 |
20170175205 | DISTINGUISHING METHYLATION LEVELS IN COMPLEX BIOLOGICAL SAMPLES - Provided herein is a method for distinguishing an aberrant methylation level for DNA from a first cell type, including steps of (a) providing a test data set that includes (i) methylation states for a plurality of sites from test genomic DNA from at least one test organism, and (ii) coverage at each of the sites for detection of the methylation states; (b) providing methylation states for the plurality of sites in reference genomic DNA from one or more reference individual organisms, (c) determining, for each of the sites, the methylation difference between the test genomic DNA and the reference genomic DNA, thereby providing a normalized methylation difference for each site; and (d) weighting the normalized methylation difference for each site by the coverage at each of the sites, thereby determining an aggregate coverage-weighted normalized methylation difference score. Also provided herein are sensitive methods for using genomic DNA methylation levels to distinguish cancer cells from normal cells and to classify different cancer types according to their tissues of origin. | 2017-06-22 |
20170175206 | METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH RISK OF AGGRESSIVE PROSTATE CANCER - The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of having or developing aggressive prostate cancer. | 2017-06-22 |
20170175207 | METHODS FOR PREDICTING THE OUTCOME OF A CANCER IN A PATIENT BY ANALYSING GENE EXPRESSION - The present invention relates to a method for predicting the outcome of a cancer in a patient by analysing gene expression in a sample obtained from said patient. More particularly the present invention relates to a method for predicting the outcome of a cancer comprising a step consisting of determining the expression level of a gene cluster consisting of at least 3 genes in a sample obtained from said patient. | 2017-06-22 |
20170175208 | METHODS FOR DETECTING TARGET DNA SEQUENCES - The invention relates to methods for detecting target DNA sequences, particularly for detecting | 2017-06-22 |
20170175209 | ARRANGEMENT AND SYSTEM FOR A TREATMENT PROCESS - An arrangement for feeding and dewatering lignocellulosic material in a hydrolysis process between a first reactor unit, where the material is partly hydrolyzed, to a second reactor unit, wherein the first reactor unit operates at a first pressure and the second reactor unit operates at a second pressure being higher than the first pressure. The arrangement includes a first plug screw feeder arranged to receive the partly hydrolyzed material from the first reactor unit and being arranged to compress, dewater and transport the material, wherein the first screw feeder is arranged to operate at a pressure being higher than the first pressure. A dilution vessel is coupled to receive material from the first plug screw feeder and including a liquid inlet for receiving liquid to wash the material, wherein the dilution vessel is arranged to maintain or increase the pressure (PDM). A second plug screw feeder is arranged to receive the diluted material and to compress, dewater and transport the material to the second reactor unit, wherein the second screw feeder is arranged to operate at a pressure being higher than the pressure of the first plug screw feeder. A system including such an arrangement and a first reactor unit and a second reactor unit is also presented. | 2017-06-22 |
20170175210 | ANIMAL HIDE DEHAIRING METHODS - Methods for preparing an animal hide for chrome tanning are provided. In particular, one or more embodiments include treating the hide with a first enzyme, a second enzyme, and a polysulfide. This treatment facilitates improved removal of hair from the hide. Furthermore, one or more embodiments include various combinations of treating the hide with a third enzyme, a liming agent, a pH-modifying agent, one or more sulfides, and one or more soaking agents. In addition, one or more embodiments include sanitizing the hide and liming the hide to further facilitate the processing of the animal hide into leather. | 2017-06-22 |
20170175211 | DEVICE FOR IMMOBILISING THE CHUTE ON THE ENDS OF JOURNALS IN AN APPARATUS FOR LOADING A SHAFT FURNACE - A device for immobilising the spout on the ends of the trunnions, in a charging installation for a shaft furnace comprising a pivoting material distribution spout ( | 2017-06-22 |
20170175212 | ARGON OXYGEN DECARBURIZATION REFINING METHOD FOR MOLTEN AUSTENITIC STAINLESS STEEL - An argon oxygen decarburization (AOD) refining method for molten austenitic stainless steel includes, preparing molten austenitic stainless steel in an electric arc furnace, pouring the molten austenitic stainless steel into an AOD refining furnace by adjusting a carbon concentration of the molten austenitic stainless steel to 2.0 wt % to 2.5 wt %, decarburizing the poured molten austenitic stainless steel by blowing oxygen (O | 2017-06-22 |
20170175213 | ANTI-GALLING METHOD FOR TREATING MATERIALS - An anti-galling method for treating materials, which provides for subjecting at least one of the at least two components mutually coupled with at least one degree of freedom, made of metallic material, to a first preliminary step of thermal treatments to increase surface hardness and to a second preliminary step of surface grinding. The method further includes the steps of: washing at least one portion of the surface of the at least one component subjected previously to the preliminary steps; shot peening the at least one portion of the surface of the at least one component previously subjected to washing; and applying a layer of molybdenum disulfide to the at least one portion of the at least one component previously subjected to shot peening. | 2017-06-22 |
20170175214 | HEAT TREATMENT DEVICE AND COOLING DEVICE - A heat treatment device includes: a heating device that heats a treatment object; a cooling device including a cooling room that accommodates the treatment object heated by the heating device and into which a cooling medium used for cooling the treatment object is supplied; a pressurized gas supplier that supplies pressurized gas into the cooling room; a pressure relief valve that communicates internal and external areas of the cooling room with each other when the pressure relief valve is opened; a pressure sensor that measures the pressure inside the cooling room; and a controller that controls the pressure relief valve such that the pressure relief valve is opened when a measurement result of the pressure sensor is higher than or equal to a threshold value. | 2017-06-22 |
20170175215 | METHOD FOR PRODUCING A COATED BODY HARDENED BY HOT FORMING AS WELL AS A BODY PRODUCED ACCORDING TO THE METHOD - A method is disclosed for producing a coated body hardened by hot forming. The base body is austenitized in a method step. The coating of the precoated base body is oxidized artificially prior to this method step. A body produced according to the method has an oxidized layer with a thickness of between 0.05 μm and 30 μm. | 2017-06-22 |
20170175216 | ELECTRICAL HEATING DEVICE - A method of producing a spring which reduces time required for a heat treatment step of eliminating a machining strain generated by a forming step is provided. This production method is provided with a forming step (S | 2017-06-22 |
20170175217 | HOT ROLLED AND ANNEALED FERRITIC STAINLESS STEEL SHEET, METHOD OF PRODUCING SAME, AND COLD ROLLED AND ANNEALED FERRITIC STAINLESS STEEL SHEET - A hot rolled and annealed ferritic stainless steel sheet includes a composition that contains, on a mass percent basis, 0.015% or less of C, 1.00% or less of Si, 1.00% or less of Mn, 0.040% or less of P, 0.010% or less of S, 12.0% or more and 23.0% or less of Cr, 0.20% or more and 1.00% or less of Al, 0.020% or less of N, 1.00% or more and 2.00% or less of Cu, and 0.30% or more and 0.65% or less of Nb, Si and Al being contained so as to satisfy expression (1) described below, the balance being Fe and incidental impurities, and the hot rolled and annealed ferritic stainless steel sheet having a Vickers hardness less than 205, Si≧Al (1) (where in expression (1), Si represents the content of Si (% by mass), and Al represents the content of Al (% by mass)). | 2017-06-22 |
20170175218 | FAR-INFRARED RADIATION HEATING FURNACE FOR STEEL SHEET FOR HOT STAMPING - The present invention provides a far-infrared radiation heating furnace for steel sheets for hot stamping configured to inhibit thermal deformation of the furnace body and furnace body parts. A far-infrared radiation heating furnace ( | 2017-06-22 |
20170175219 | HIGH-STRENGTH STEEL SHEET AND PRODUCTION METHOD FOR SAME, AND PRODUCTION METHOD FOR HIGH-STRENGTH GALVANIZED STEEL SHEET - Disclosed is a high-strength steel sheet having a predetermined chemical composition, satisfying the condition that Mn content divided by B content equals 2100 or less, and a steel microstructure that contains, by area, 25-80% of ferrite and bainitic ferrite in total, 3-20% of martensite, and that contains, by volume, 10% or more of retained austenite, in which the retained austenite has a mean grain size of 2 μm or less, a mean Mn content in the retained austenite in mass % is at least 1.2 times the Mn content in the steel sheet in mass %, and an aggregate of retained austenite formed by seven or more identically-oriented retained austenite grains accounts for 60% or more by area of the entire retained austenite. | 2017-06-22 |
20170175220 | MANUFACTURING METHOD OF PRESSURE SENSOR - A manufacturing method of a pressure sensor, in which the pressure sensor includes: a metal joint having an introduction hole configured to flow a measurement target fluid therethrough; and a sensor module metal member including: a cylindrical portion provided to the joint; a diaphragm; and a dent configured to receive the measurement target fluid from the introduction hole, includes: welding the joint to the sensor module metal member; and subsequently, heating the joint and the sensor module metal member. | 2017-06-22 |
20170175221 | HIGH-CARBON STEEL WIRE ROD AND PREPARATION METHOD THEREFOR - There is provided a high-carbon steel wire rod and a preparation method thereof. Wherein, the high-carbon steel wire rod comprising the following ingredients: C, Si, Mn, Cr, V, Ti and Fe. The high-carbon steel wire rod has satisfactory mechanical properties, including high strength with an average tensile strength of 1560 MPa as well as good plasticity with an average after-fracture shrinkage rate of 30% and an after-fracture elongation percentage larger than or equal to 9%, which can meet the performance requirements for producing 2300 MPa level pre-stressed steel strand. | 2017-06-22 |
20170175222 | TOOL ARRANGEMENT FOR INTEGRATION IN A PRODUCTION LINE FOR PRODUCING A HOT FORMED COMPONENT FROM A BLANK, PRODUCTION LINE WITH THE TOOL ARRANGEMENT AND METHOD FOR PRODUCING THE HOT FORMED COMPONENT FROM THE BLANK USING THE PRODUCTION LINE - A tool arrangement is disclosed for integration in a production line for producing a hot formed component from a blank which is produced from a hot forming steel strip. The tool arrangement includes a housing, which delimits an interior of the tool arrangement relative to a surroundings of the tool arrangement, a tempering station for tempering the blank and a hot forming station for hot forming the blank. The tempering station and the hot forming station are jointly arranged in the interior. | 2017-06-22 |
20170175223 | BIOLEACHING METHOD AND FACILITY - A method for the lagoon-based bioleaching of a metallic ore, wherein the temperature of the suspension containing the metallic ore to be bioleached, a bioleaching consortium and a nutritive substrate of the microorganisms of the consortium is controlled by regulating the flows and the composition of a gas containing oxygen and optionally also CO2 injected into the suspension, the temperature of the suspension being controlled such that it can be maintained within a pre-determined range suitable for bioleaching. | 2017-06-22 |
20170175224 | SILVER RECOVERY BY ION EXCHANGE - The present invention according provides a method of recovering silver from silver containing halide solutions, comprising the steps of: (a) providing an ion exchange column comprising a weak anion exchange resin; (b) introducing the silver containing halide solution to the ion exchange column to absorb silver in the weak anion exchange resin; (c) washing the loaded ion exchange resin with a first washing solution to rinse off absorbed zinc and optionally at least part of copper; (d) washing the loaded ion exchange resin with a second washing solution to rinse off remaining copper; and (e) optionally washing the loaded ion exchange resin with a third washing solution to rinse off absorbed lead; and (f) eluting the loaded ion exchange resin with an eluent to remove silver from the resin and to obtain a silver containing solution. | 2017-06-22 |
20170175225 | SCANDIUM RECOVERY PROCESS - The purpose of the present invention is to recover roughly purified scandium, which is purified to an extent acceptable for a technique for highly purifying scandium, efficiently and without any complicated operation from a neutralization sediment (drainage sediment) generated in neutralizing acid mine drainage which contains a sulfur component. This scandium recovery process includes a washing step (S | 2017-06-22 |
20170175226 | Apparatus and Process for the Improved Economic Extraction of Metal from a Metal-Bearing Material - The present invention relates to an improved apparatus for economically extracting metal from a metal-bearing material. In particular, the present invention relates to an improved apparatus for extracting metal, including inter alia base metal (i.e. copper) and gold, from a metal-bearing ore, concentrate or other metal-bearing material. The present invention further extends to a process for the extraction of such metal which is carried out in accordance with the aforementioned apparatus. According to a first aspect thereof, the present invention provides an apparatus for extracting metal from a metal-bearing material, said apparatus, including a feed receptacle for receiving a metal-bearing feed stream; a reaction vessel; at least one pump means for delivering the metal-bearing feed stream to the reaction vessel; a means for introducing leaching agents, in the form of a leaching agent solution, to the reaction vessel; a means of agitation by circulating the metal-bearing feed stream and leaching agent solution in the reaction vessel so as to allow for a combination of agitation (tank) leaching and vat leaching to take place; a means for achieving liquid/solid separation; and a means for extracting a metal containing product; —wherein said apparatus is re-locatable and transportable in order to allow the apparatus to be assembled easily on site without being geographically bound to one specific site. | 2017-06-22 |
20170175227 | HYDROMETALLURGICAL PROCESS FOR NICKEL OXIDE ORE - Provided is a hydrometallurgical process for nickel oxide ore for recovering nickel and cobalt using a high pressure acid leach process, the process achieving simplification and durability improvement of production facilities, achieving cost reduction and suppression of environmental risk by the compression of the capacity of a tailings dam for storing wastes, and being capable of recycling and effectively utilizing the wastes as a resource. The hydrometallurgical process for nickel oxide ore for recovering nickel and cobalt using a high pressure acid leach process includes an ore processing step, a leaching step, a solid-liquid separation step, a neutralization step, a zinc removal step, a sulfurization step, and a final neutralization step, and further includes step (A), or further includes step (A) and, step (B- | 2017-06-22 |
20170175228 | RECOVERY OF LITHIUM FROM SILICATE MINERALS - A process is disclosed for recovering lithium from a lithium-containing silicate mineral. The process comprises mixing the silicate mineral with nitric acid. The process also comprises subjecting the mixture to a leaching process having conditions such that lithium values in the silicate mineral are leached into an aqueous phase as lithium nitrate. The leaching process conditions may be controlled such that non-lithium values in the silicate mineral tend not to be leached into the aqueous phase. | 2017-06-22 |
20170175229 | METHODS AND COMPOSITION FOR SEQUENTIAL ISOLATION OF RARE EARTH ELEMENTS - Methods and compositions are described in which amine-based compounds are utilized in the recovery of rare earth elements from solution. The rare earth elements are recovered selectively and sequentially. | 2017-06-22 |
20170175230 | ALUMINIUM ALLOY FOR USE IN THE BUILDING INDUSTRY - A method of making from a rolled aluminium alloy sheet a product for outdoor use in the building industry, wherein the aluminium alloy has the following composition, in wt. %: Si 0.6 to 1.6, Mg 0.10 to 0.50, Mn 0.6 to 1.6, Cu 0.10 to 0.6, Fe 0.05 to 0.7, Ti 0.05 to 0.20, Zn up to 0.4, others and unavoidable impurities, each 0.05% max, total 0.25%, balance aluminium. Furthermore, the use of the sheet product for outdoor use in the building industry is disclosed. | 2017-06-22 |
20170175231 | ALUMINUM ALLOY PLATE HAVING EXCELLENT MOLDABILITY AND BAKE FINISH HARDENING PROPERTIES - An aluminum alloy sheet excellent in terms of formability and bake hardenability which contains in terms of mass %, Mg: 0.2 to 2.0%, Si: 0.3 to 2.0% and Sn: 0.005 to 0.3%, with the remainder being Al and unavoidable impurities. A differential scanning calorimetry curve of the aluminum alloy sheet has an endothermic peak in a temperature range of 150 to 230° C. and an exothermic peak in a temperature range of 240 to 255° C. The endothermic peak corresponds to a dissolution of a Mg—Si cluster and has a peak height of 8 μW/mg or less, including 0 μW/mg. The exothermic peak corresponds to a formation of a Mg—Si cluster and has a peak height of 20 μW/mg or larger. | 2017-06-22 |
20170175232 | THERMAL INSULATION MATERIAL AND PRODUCTION METHOD THEREOF - A thermal insulation material containing an Al—Cu—Fe-based alloy, wherein at least part of the Al—Cu—Fe-based alloy comprises a quasicrystalline phase, wherein the Al—Cu—Fe-based alloy contains one or more transition elements selected from the group of Ru, Rh, Pd, Ag, Os, Jr, Pt, and Au, and wherein the total of the transition elements is from 0.25 to 0.75 atom % when the whole of the Al—Cu—Fe-based alloy is 100 atom %. | 2017-06-22 |
20170175233 | ALUMINUM MICROSTRUCTURE FOR HIGHLY SHAPED PRODUCTS AND ASSOCIATED METHODS - Aluminum and aluminum alloy microstructures that are adapted for improved performance during shaping and forming production processes. Lower relative ratios of alpha fibers, particularly low-end alpha fibers, to beta fibers promotes improved formability of aluminum sheet or blanks without negatively impacting material strength. Beta fibers with higher relative ratios of S and Copper texture components improve formability and produce fewer and more uniform distortions during production. The resulting improvements in quality allow for cupping, drawing, wall ironing, shaping, and necking processes to be carried out faster and with reduced rates of spoilage. | 2017-06-22 |
20170175234 | METAL COATED HEAVY METAL POWDER FOR ADDITIVE MANUFACTURING OF HEAVY METAL PARTS - A heavy metal part and method of manufacturing includes a dense alloy or a metallic composite consisting of a plurality of dense metal particles formed of a first metal and a melted metal matrix that is a continuous phase of the first metal and a second metal having a lesser density than the first metal. The metal particles are a discrete phase within the continuous phase and the heavy metal part is formed by an additive manufacturing process of a powder feedstock comprising the metal particles coated with the second metal. | 2017-06-22 |
20170175235 | CR, NI, MO AND CO ALLOY FOR USE IN MEDICAL DEVICES - One aspect generally relates to a Cr, Ni, Mo and Co alloy, with tightly controlled levels of impurities. One aspect relates to an alloy including about 10 to about 30 weight % Cr, about 20 to about 50 weight % Ni, about 2 to about 20 weight % Mo, about 10 to about 50 weight % Co, and less than about 0.01 weight % Al, wherein each weight % is based on the total weight of the alloy. | 2017-06-22 |
20170175236 | INDUCTION HEATABLE STAINLESS STEEL SHEET HAVING EXCELLENT CORROSION RESISTANCE AND METHOD OF MANUFACTURING THE SAME - A stainless steel sheet for cookware and a method of manufacturing the same and, particularly, an induction heatable stainless steel sheet having excellent corrosion resistance and a method of manufacturing the same are provided. The induction heatable stainless steel sheet having excellent corrosion resistance includes, by wt %, C: 0.1% or less (excepting 0%), Si: 0.2% to 3.0%, Mn: 1.0% to 4.0%, Cr: 19.0% to 23.0%, Ni: 0.3% to 2.5%, N: 0.18% to 0.3%, Cu: 0.3% to 2.5%, iron (Fe) as a residual component thereof, and other unavoidable impurities, and has relative permeability of 20μ | 2017-06-22 |
20170175237 | FERRITIC STAINLESS STEEL AND METHOD FOR PRODUCING SAME, AND HEAT EXCHANGER EQUIPPED WITH FERRITIC STAINLESS STEEL AS MEMBER - A ferritic stainless steel, which has excellent heat exchange properties, corrosion resistance and brazing property of the heat exchanger component, and a heat exchanger using the ferritic stainless steel are provided. The ferritic stainless steel includes, in a mass %, C: 0.030% or less, N: 0.020% or less, Si: 0.5% or less, Mn: 1.0% or less, P: | 2017-06-22 |
20170175238 | ALUMINUM ALLOY MATERIAL AND JOINED BODY HAVING EXCEPTIONAL ADHESIVE ENDURANCE, AND AUTOMOTIVE COMPONENT - An aluminum alloy material, containing Al, Mg, Si and Sn, where an oxide coating is formed on a surface of the aluminum alloy material, and when the oxide coating formed on the surface of the aluminum alloy material is subjected to glow discharge emission spectroscopic analysis, as the maximum value of each content of Sn and Mg for a region from the surface of the oxide coating to a depth where oxygen amount becomes 15 at %, a Sn content is within a range of 0.01-10 at %, and a Mg content is 0 at % or more and less than 10 at %. | 2017-06-22 |
20170175239 | HIGH STRENGTH 6XXX ALUMINUM ALLOYS AND METHODS OF MAKING THE SAME - Provided are new high strength 6xxx aluminum alloys and methods of making aluminum sheets thereof. These aluminum sheets may be used to fabricate components which may replace steel in a variety of applications including the transportation industry. In some examples, the disclosed high strength 6xxx alloys can replace high strength steels with aluminum. In one example, steels having a yield strength below 340 MPa may be replaced with the disclosed 6xxx aluminum alloys without the need for major design modifications. | 2017-06-22 |
20170175240 | HIGH-STRENGTH 6XXX ALUMINUM ALLOYS AND METHODS OF MAKING THE SAME - Disclosed are high-strength aluminum alloys and methods of making and processing such alloys. More particularly, disclosed is a 6XXX series aluminum alloy exhibiting improved mechanical strength, formability, corrosion resistance, and anodized qualities. An exemplary method includes homogenizing, hot rolling, solutionizing, and quenching. In some cases, the processing steps can further include annealing and/or cold rolling. | 2017-06-22 |
20170175241 | METHOD TO PREVENT ABNORMAL GRAIN GROWTH FOR BETA ANNEALED TI-6AL-4V FORGINGS - A method for heat-treating a titanium alloy, such as Ti-6Al-4V. The method may occur after or include a step of forging the titanium alloy such that localized, highly deformed grains are formed in the titanium alloy. Then the method may include steps of recrystallization annealing the titanium alloy by heating the titanium alloy to a temperature in a range between 30° F. to 200° F. below beta transus of the titanium alloy for 1 hour to 6 hours and then furnace cooling of the titanium alloy to 1200° F. to 1500° F. at a rate of 50° F. to 500° F. per hour. Following the recrystallization annealing, the method may include beta annealing the titanium alloy. These steps may be performed in a single heat treating cycle. | 2017-06-22 |
20170175242 | HYDROPHOBIC ALLOY FILM AND MANUFACTURING METHOD THEREOF - A hydrophobic alloy film and a manufacturing method thereof are provided. The hydrophobic alloy film includes Al, Cu, O, and at least one selected from the group consisting of Fe, Co, Ni, and Cr, or Ti, Zr, O, and at least one selected from the group consisting of Fe, Co, Ni, and Cr. The content of each of Al and Ti is in the range of 40 at. % to 70 at. %. The content of each of Cu and Zr is in the range of 10 at. % to 40 at. %. The total content of at least one selected from the group consisting of Fe, Co, Ni, and Cr is in the range of 10 at. % to 30 at. %. The content of O is in the range of 10 at. % to 30 at. %. The hydrophobic alloy film has a quasicrystal structure and nanoparticles. | 2017-06-22 |
20170175243 | METHOD FOR HOT-DIP COATING A STEEL STRIP AND FACILITY FOR IMPLEMENTING SAME - A method for hot-dip coating of a steel strip running in a bath of liquid metal such as zinc, or metal alloy contained in a pan is provided. Dross which are formed during the coating and float at the surface of the bath are moved away from the surface of the strip by at least one inductor. Each inductor produces a sliding electromagnetic field oriented along a given direction and generates a magnetomotive force, and the magnetomotive forces displaced the dross towards a container intended to collect them and/or towards an area of the surfaceof the bath from which they are discharged. For at least one of the inductors, the direction of the respective sliding electromagnetic field is reversed intermittently so as to modify the flows of the dross inside the pan. A hot dip coating facility is also provided. | 2017-06-22 |
20170175244 | COATED ARTICLES AND METHOD FOR MAKING - An article includes a substrate comprising a precipitate-strengthened alloy and a coating disposed over the substrate. The alloy comprises a) a population of gamma-prime precipitates, the population having a multimodal size distribution with at least one mode corresponding to a size of less than about 100 nanometers; or b) a population of gamma-double-prime precipitates having a median size less than about 300 nanometers. The coating comprises at least two elements, and further comprises a plurality of prior particles. At least a portion of the coating is substantially free of rapid solidification artifacts. Methods for fabricating the article and for processing powder useful for fabricating the article are also provided. | 2017-06-22 |
20170175245 | DURABLE MgO-MgF2 COMPOSITE FILM FOR INFRARED ANTI-REFLECTION COATINGS - This disclosure is directed to an optic having a composited MgO—MgF | 2017-06-22 |
20170175246 | METHOD FOR PRODUCTION OF A COMPOSITE LAYER COMPRISING A PLASTIC FOIL AND A LAYER DEPOSITED THEREON - Methods are provided for production of a composite layer comprising a plastic foil and a layer deposited directly thereon. A method for production of a composite layer comprising a plastic foil and at least one layer deposited directly onto the plastic foil by means of chemical gas-phase deposition within a vacuum chamber may be provided, wherein the plastic foil has a proportion of at least 20 percent by mass of a metal element or of a semiconductor element, wherein during the layer deposition, at least one monomer is supplied into the vacuum chamber and a plasma is formed within the vacuum chamber. After completed deposition of the layer, at least one surface region of the layer is exposed to accelerated electrons. | 2017-06-22 |
20170175247 | SPUTTERING SOURCE ARRANGEMENT, SPUTTERING SYSTEM AND METHOD OF MANUFACTURING METAL-COATED PLATE-SHAPED SUBSTRATES - For coating substrates (S) having along their surfaces to be coated high aspect ratio vias, a sputtering system has a sputtering source arrangement, which includes a first DC pulse operated magnetron sub-source ( | 2017-06-22 |
20170175248 | MAGNETICALLY ENHANCED LOW TEMPERATURE-HIGH DENSITY PLASMA-CHEMICAL VAPOR DEPOSITION PLASMA SOURCE FOR DEPOSITING DIAMOND AND DIAMOND LIKE FILMS - A magnetically enhanced low temperature high density plasma chemical vapor deposition (LT-HDP-CVD) source has a hollow cathode target and an anode, which form a gap. A cathode target magnet assembly forms magnetic field lines substantially perpendicular to the cathode surface. A gap magnet assembly forms a magnetic field in the gap that is coupled with the cathode target magnetic field. The magnetic field lines cross the pole piece electrode positioned in the gap. The pole piece is isolated from ground and can be connected to a voltage power supply. The pole piece can have negative, positive, floating, or RF electrical potentials. By controlling the duration, value, and sign of the electric potential on the pole piece, plasma ionization can be controlled. Feed gas flows through the gap between the hollow cathode and anode. The cathode can be connected to a pulse power or RF power supply, or cathode can be connected to both power supplies. The cathode target and substrate can be inductively grounded. | 2017-06-22 |
20170175249 | THIN METAL FILM SUBSTRATE AND METHOD FOR PREPARING THE SAME - The present disclosure related to a thin metal film substrate and a method for preparing the same and more particularly, to a thin metal film substrate including a substrate; and a thin metal film comprising Ag or an Ag alloy formed on the substrate, wherein the thin metal film is formed to have preferred orientation corresponding to the preferred orientation of the substrate during the initial growth. The thin metal film substrate according to an example grows in a 2D continuous thin film from the initial growth to provide excellent light transmittance and conductivity. | 2017-06-22 |
20170175250 | EVAPORATION SOURCE, EVAPORATION-DEPOSITION DEVICE AND EVAPORATION-DEPOSITION METHOD - Disclosed are an evaporation source, an evaporation-deposition device and an evaporation-deposition method. The evaporation source comprises: a crucible configured to generate an evaporation-deposition gas; a crucible top cover arranged on the crucible to seal the crucible; and a plurality of crucible nozzles arranged on the crucible top cover and configured to spray the evaporation-deposition gas from the crucible. The evaporation source further comprises a clogging heater configured to heat the crucible nozzles. The clogging heater may directly heat the crucible nozzle, so as to evaporate the coagulated organic evaporation-deposition material. According to the disclosure, a pressure inside the crucible can be kept constant, ensuring that an article can have an organic evaporation-deposition material layer with uniform thickness. | 2017-06-22 |
20170175251 | SURROUNDING FIELD SPUTTERING SOURCE - A sputtering cathode includes a magnet having a body of length L | 2017-06-22 |
20170175252 | Sputtering Target Comprising Al-Te-Cu-Zr Alloy, and Method for Producing Same - An Al—Te—Cu—Zr alloy sputtering target, comprising 20 at % to 40 at % of Te, 5 at % to 20 at % of Cu, 5 at % to 15 at % of Zr and the remainder of Al, wherein a Te phase, a Cu phase and a CuTe phase are not present in a structure of the target. An object of the present invention is to provide an Al—Te—Cu—Zr alloy sputtering target capable of effectively reducing particle generation, nodule formation and the like upon sputtering and further capable of reducing oxygen contained in the target. | 2017-06-22 |
20170175253 | MAGNETICALLY ENHANCED HIGH DENSITY PLASMA-CHEMICAL VAPOR DEPOSITION PLASMA SOURCE FOR DEPOSITING DIAMOND AND DIAMOND-LIKE FILMS - A magnetically enhanced HDP-CVD plasma source includes a hollow cathode target and an anode. The anode and cathode form a gap. A cathode target magnet assembly forms magnetic field lines that are substantially perpendicular to a cathode target surface. The gap magnet assembly forms a cusp magnetic field in the gap that is coupled with the cathode target magnetic field. The magnetic field lines cross a pole piece electrode positioned in the gap. This pole piece is isolated from ground and can be connected with a voltage power supply. The pole piece can have a negative, positive, or floating electric potential. The plasma source can be configured to generate volume discharge. The gap size prohibits generation of plasma discharge in the gap. By controlling the duration, value and a sign of the electric potential on the pole piece, the plasma ionization can be controlled. The magnetically enhanced HDP-CVD source can also be used for chemically enhanced ionized physical vapor deposition (CE-IPVD). Gas flows through the gap between hollow cathode and anode. The cathode target is inductively grounded, and the substrate is periodically inductively grounded. | 2017-06-22 |
20170175254 | SUBSTRATE CARRIER THAT CARRIES A SUBSTRATE ON EACH OF TWO BROAD SIDES OF THE SUBSTRATE CARRIER THAT FACE AWAY FROM EACH OTHER - A substrate carrier is configured to be arranged in a CVD or PVD reactor, in particular for the deposition of carbon nanotubes or graphene. The substrate carrier has a first broadside surface and a second broadside surface facing away from the first broad-side surface. The first broadside surface and the second broadside surface of the substrate carrier each have a substrate accommodation zone. Fastening elements are provided within each of the substrate accommodation zones to secure a substrate or sections of a substrate to one or more of the broadside surfaces. A CVD reactor is further configured to receive the substrate carrier. | 2017-06-22 |
20170175255 | METHOD OF SPUTTER DEPOSITION OF A FILM ON AN ESSENTIALLY PLANE EXTENDED SURFACE OF A SUBSTRATE - A film is sputter-deposited on an essentially plane, extended surface of a substrate which has recesses therein, namely at least one of grooves, of holes, of bores, of vias, of trenches. So as to establish on one hand a homogeneous thickness distribution of the film along the addressed surface of the substrate and, on the other hand, a thick film deposition within the recesses, sputter deposition is performed first at a large distance between a sputter surface of a target and the addressed surface of the substrate and then at a reduced distance between the addressed surfaces. | 2017-06-22 |
20170175256 | System and Method for Deposition of Integrated Computational Elements (ICE) Using a Translation Stage - The disclosed embodiments include a system and method for manufacturing an integrated computational element (ICE) core. In one embodiment, the method comprises thermally evaporating a material to deposit the material on a substrate, wherein the material is deposited to establish a shape of the ICE core. The shape of the ICE core defines transmission, reflection, and absorptive electromagnetic intensity as a function of wavelength of the ICE core. In one embodiment, the method includes varying e-beam or ion-beam intensities and strengths to control the shape of the ICE core. | 2017-06-22 |