25th week of 2019 patent applcation highlights part 11 |
Patent application number | Title | Published |
20190184032 | PACLITAXEL-ALBUMIN-BINDING AGENT COMPOSITIONS AND METHODS FOR USING AND MAKING THE SAME - Described herein are nanoparticle compositions comprising binding agents, carrier proteins and an amount of paclitaxel derivative, and optionally a therapeutic agent. Also described herein are nanoparticle compositions comprising carrier proteins and an amount of paclitaxel, and optionally binding agents and/or a therapeutic agent, wherein the paclitaxel is present in an amount that is less than an amount that provides a therapeutic effect. Also disclosed herein are nanoparticles which contain (a) carrier protein, (b) a paclitaxel derivative, the paclitaxel derivative having reduced toxicity compared to paclitaxel, and optionally (c) a binding agent and/or (d) a therapeutic agent. Also described are methods of making and using the same, in particular, as a cancer therapeutic. | 2019-06-20 |
20190184033 | MODIFIED DYSTROPHIN PROTEINS - Synthetic nucleic acids encoding mini and microdystrophin genes comprising the membrane binding motifs or domains of the R10-R11-R12 region are provided. Also provided are vectors, host cells, and related methods of using the same to treat a subject suffering from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) or X-linked dilated cardiomyopathy (XLDC), or for ameliorating one or more adverse effects of DMD, BMD, or XLDC. Also provided are a fusion protein comprising a nNOS binding domain of dystrophin R16-R17 that is operably linked to a syntrophin PDZ domain and synthetic nucleic acids comprising the same that can be used to treat subjects with diseases characterized by loss of sarcolemmal neuronal nitric oxide synthase (nNOS) activity. | 2019-06-20 |
20190184034 | USE OF hM4Di IN THE TREATMENT OF SEIZURE DISORDERS - Methods and compositions for treating a seizure disorder are provided which include administering to the patient an adeno-associated virus vector encoding hM4Di for delivery of hM4Di to a target location, the vector including a human or murine CaMKII promoter, a woodchuck hepatitis virus post-transcriptional regulatory element, and a bovine growth hormone polyadenylation sequence, and administering to the patient a synthetic ligand which activates hM4Di. Administration of the vector and synthetic ligand to a patient with a seizure disorder is associated with reduced symptoms of the seizure disorder. In embodiments, ultrasound is applied to a target location in the patient's brain to enhance permeability of the patient's blood brain barrier to the vector and/or synthetic ligand. | 2019-06-20 |
20190184035 | BCL11A HOMING ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE - The present disclosure provides improved genome editing compositions and methods for editing a BCL11A gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy. | 2019-06-20 |
20190184036 | CELL-PERMEABLE IMAGING SENSORS AND USES THEREOF - The disclosure relates in some aspects to imaging agents, and in particular, imaging agents for sensing of calcium signaling. According to some embodiments of the disclosure, contrast agents for magnetic resonance imaging and related technologies are provided, and methods of making and using the contrast agents. | 2019-06-20 |
20190184037 | PARAMAGNETIC BORON-DOPED GRAPHENE QUANTUM DOTS AND THEIR APPLICATION FOR SAFE MAGNETIC RESONANCE IMAGING - Boron-doped graphene quantum dots, methods for making the boron-doped graphene quantum dots, and methods for magnetic resonance imaging using the boron-doped graphene quantum dots. | 2019-06-20 |
20190184038 | PHOSPHOLIPID COMPOSITION AND MICROBUBBLES AND EMULSIONS FORMED USING SAME - A composition, and method thereof, for stabilizing a fluorocarbon emulsion includes phosphatidylcholine, phosphatidylethanolamine-PEG, and a cone-shaped lipid. | 2019-06-20 |
20190184039 | LABELLED CARBOXYLIC ACIDS AND THEIR USES IN MOLECULAR IMAGING - The present invention pertains generally to the field of imaging compounds, and more specifically to certain 2,2-dialkyl radionuclide-labelled carboxylic acids suitable for PET, SPECT and/or DNP imaging. Also described are used of such compounds in the imaging of inter alia, cancer tumours, metastasis, Alzheimer's disease and multiple sclerosis. | 2019-06-20 |
20190184040 | Targeted Macrocyclic Agents for Dual Modality PET and MRI Imaging of Cancer - Dual-modality contrast agents are disclosed herein, having the general formula: | 2019-06-20 |
20190184041 | CHELATING PLATFORM FOR DELIVERY OF RADIONUCLIDES - Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes. | 2019-06-20 |
20190184042 | PET IMAGING WITH PD-L1 BINDING POLYPEPTIDES - Provided herein are novel | 2019-06-20 |
20190184043 | IMAGING METHODS USING 18F-RADIOLABELED BIOLOGICS - The invention relates to water soluble | 2019-06-20 |
20190184044 | HANDHELD UV DISINFECTANT UNIT - An ultraviolet (UV) light disinfectant unit is sized for portability and handheld use. The handheld UV light disinfectant unit includes a shell defining an interior cavity. A UV light is provided on an exterior of the shell. A transparent lens cap is provided over the UV light and is removably mounted to the shell. At least one writing instrument such as a pen and/or stylus is integrated into the handheld UV light disinfectant unit. The writing instrument is extendable away from the shell and retractable into the interior cavity. A slider button may be provided to slide the writing instrument between the retracted position and the extended position. A combination of a UV light and a writing instrument in a handheld device provides a user with a multiuse tool to accomplish tasks such as writing on publicly accessible screens that may make multiple steps of disinfecting desirable. | 2019-06-20 |
20190184045 | ULTRAVIOLET STERILIZATION DEVICE - An ultraviolet sterilization device includes a processing chamber that houses a subject of sterilization and a light source that irradiates an interior of the processing chamber with ultraviolet light. A wall of the processing chamber has a stack structure including a first layer made of a fluororesin material and a second layer made of of an ultraviolet reflective material, the first layer being provided on the inner side of the processing chamber. The light source includes an aluminum gallium nitride (AlGaN) based ultraviolet light emitting device. | 2019-06-20 |
20190184046 | Device and Method for Introducing Electromagnetic Radiation Efficiently into Soil - The invention relates to a device for treating soil with electromagnetic radiation, comprising:—a magnetron antenna ( | 2019-06-20 |
20190184047 | METHOD AND A DEVICE FOR STERILIZATION BY PLASMA - A method of sterilizing an object in a sterilization chamber comprises: evacuating the sterilization chamber at a pressure value; injecting a gaseous phase into at least one plasma generator via an ionization duct, the injected gaseous phase comprising dinitrogen with a volume content of dioxygen, a first ratio of the flow rate for injecting the gaseous phase in each plasma generator over the volume of the sterilization chamber being maintained at a value that is greater than or equal to 0.02 min | 2019-06-20 |
20190184048 | FLOW RESTRICTOR - An apparatus that assists in sterilizing an endoscope inside a sterilizer employing a gaseous sterilant, e.g., hydrogen peroxide, is disclosed. The apparatus may include a dry booster and a flow restrictor that includes two tubes, which may be connected to channels of an endoscope and the dry booster. The flow restrictor may be used to change the flow rates through the channels to assist in delivering sterilant throughout the channels. | 2019-06-20 |
20190184049 | Rolled Fibrous Structures Comprising Encapsulated Malodor Reduction Compositions - The present invention relates to a fibrous structure including one or more encapsulated malodor reduction compositions and methods of making and using such a fibrous structure. | 2019-06-20 |
20190184050 | DEVICE FOR EMANATING MATERIALS - A device for emanating materials in the environment, preferably by heat evaporation, including: a supply for materials; an emitter of materials, for emitting the materials from the supply to surrounding environment, by application of power from a power supply according to an operation mode; an operation mode adjusting mechanism for adjusting the operation mode of the emitter, by controlling the power delivered to the emitter according to a determined transfer function. The transfer function is modular, so that it can be changed or completely replaced while keeping at least partially the adjusting mechanism in the device. | 2019-06-20 |
20190184051 | COMPACT AROMATIC DIFFUSER AND METHOD OF USE - A compact aromatic diffuser configured to be used in conjunction with a breathing mask, allowing full consumption of the diffused essential oil by the user. The compact aromatic diffuser may also be used as a hand held inhaler for application proximate the user's face or a standalone diffuser for treating the atmosphere in a room or closed compartment. | 2019-06-20 |
20190184052 | WOUND DRESSING AND A METHOD FOR PRODUCING THE SAME - The invention provides a wound dressing made by an ex vivo formed combination of fibrinogen and/or fibrin containing-liquid formulation and an oxidized cellulose (OC) backing; and use thereof. | 2019-06-20 |
20190184053 | Biaxially Transformed Sponges - A sheet sponge ( | 2019-06-20 |
20190184054 | COMPOSITIONS FOR THE TREATMENT OF PAIN AND/OR INFLAMMATION - Compositions for the treatment of pain and/or inflammation comprising at least one peptide with the general formula (I) R | 2019-06-20 |
20190184055 | Dressing Enabling the Controlled and Prolonged Release of Metformin - The subject matter of the present invention is, according to a first aspect, a dressing comprising an interface layer, characterised in that said interface layer comprises a weave coated with an elastomeric matrix comprising metformin, the salts and the complexes thereof. The subject matter of the invention is also a dressing comprising metformin, characterised in that the percentage of metformin released after 72 hours is between 40 and 100% of the quantity of metformin inserted in the dressing. Moreover, the subject matter of the invention is a method for producing said dressing as well as the use thereof for healing a wound. | 2019-06-20 |
20190184056 | METHOD FOR USING AN ADHESIVE COMPOSITION IN BONE PRESERVATION AND AUGMENTATION - A method comprising the steps of applying an adhesive composition to a substrate bone repair region. The adhesive composition comprises a porous, biocompatible, biodegradable, resorbable, non-toxic, and polymerizable composition. The substrate bone repair region comprises a bone structure, implant or device surface, or tooth surface. The adhesive composition is cured to provide a polymerized adhesive composition resulting in repairing or augmenting the substrate bone repair region. The adhesive composition may be mixed with a bone graft material before application. The adhesive composition may be additionally applied to a barrier membrane that is placed over the substrate bone repair region where the adhesive composition or combination of adhesive composition and bone graft material is applied. | 2019-06-20 |
20190184057 | WOUND COVERING WITH HAEMOSTATIC ACTION AND THE METHOD OF ITS CREATION - The present invention relates to the field of medicine, generally to the field of surgical and emergency medical wound covering means on the base of haemostatic composition designated as Hemoblok. The invention proposes a new method of usage of these haemostatic compositions to activate the formation of artificial clots that can adhere to wounded tissue for the suppression of fluid loss and for the protection of viable tissue. The method consists of the steps to be applied to the open wound a grid-forming water-soluble haemostatic Hemoblok composition consisting of a polyacrylic matrix as an active ingredients, creating by Hemoblok the clot formation with the blood plasma proteins, preferably with albumin, creating a structure containing albumin molecules in the cells of the polyacrylic matrix (grid), which is the primary organizer of sustainable polyacrylic film, further forming by Hemoblok the multilayered solid polyacrylic film, then the replacement by fibrin of the surface structure hemoblok-protein and implementation of plasma formation of the polyacrylic matrix. Another object of the invention is a kit for creation of wound covering, comprising, packaged in association a Hemoblok composition, and a dispenser for applying the Hemoblok to open wounds, which is made as a woven or a non-woven fabric, a tube, a bandage or a container having at least one opening. | 2019-06-20 |
20190184058 | Porous Metal Devices - Devices comprising a component which has an open porous structure composed of an alloy of nickel and titanium or a mixture of nickel and titanium. The devices can be implanted in a mammalian body and provide desired interaction with protein, blood, ions, bone cells, and tissue. The devices are particularly useful for providing a substrate for the ingrowth of bone. In the open pore structure, preferably more than 95% of the pores having a size of 50-1000 μm, particularly 50-600 μm, with a pore size standard deviation of 250 μm or less, particularly of 150 μm or less, and an average porosity by volume of 40-80%. When the device is implanted adjacent to a cancellous bone, the porous component preferably has a modulus of 0.1-1.2 GPa. When the device is implanted adjacent to cortical bone, the porous component preferably has a modulus of 16 to 24 GPa. The devices are also useful for filtering a liquid. | 2019-06-20 |
20190184059 | BONE SUBSTITUTE MATERIAL - A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a homogeneous coarse external surface comprising flat crystal platelets, which shows an enhanced osteogenic response, a method of promoting bone formation, bone regeneration and/or bone repair by implanting the biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material, and a process of preparation thereof. | 2019-06-20 |
20190184060 | EXTRACELLULAR MATRIX FOR TISSUE RECONSTRUCTION OF MUCOSAL TISSUE - Described are methods and compositions for treatment of reproductive or urogenital mucosal tissue damage using Extracellular Matrix (ECM) solution and, particularly, Extracellular Matrix Hydrogel (ECMH) solution delivered to the target site for tissue repair, restoration, remodeling, or reconstruction. | 2019-06-20 |
20190184061 | COMPOSITION FOR CARTILAGE REGENERATION AND PREPARING THEREOF - The present invention provides a cartilage regenerating composition including a fetal cartilage tissue-derived cell and an extracellular matrix derived from a fetal cartilage tissue, and a preparing method thereof. According to the present invention, the cartilage-regenerating composition may produce a three-dimensional tissue of a size suitable for use as a cartilage without a scaffold, may be easily transplantable regardless of the size and shape of the cartilage defect at the site of administration since it can be administered in the form of a gel, but has high application and adhesion, may exhibit a high binding ability to the host tissue, and may have a phenotype of mature cartilage tissue, thereby exhibiting an excellent cartilage regeneration effect. | 2019-06-20 |
20190184062 | REINFORCED BIOLOGIC MATERIAL - The present disclosure provides an implantable medical device comprising a composite graft material including a first biologic component, such as an acellular tissue matrix, and a second non-biologic component. | 2019-06-20 |
20190184063 | NEURONAL SCAFFOLD-WATER SOLUBLE GRAPHENE FOR TREATMENT OF SEVERED SPINAL CORDS AND NEURONAL REPAIR - Graphene compositions used for neuronal repair and treatments, and, in particular neuronal scaffold-water soluble graphene for treatment of severed spinal cords and other neuronal repairs. The neuronal scaffold-water soluble graphene can be PEGylated GNR used in combination with a fusogen agent, such as PEG600. | 2019-06-20 |
20190184064 | Composition for Soft Tissue Augmentation Providing Protection from Infection - A therapeutic filler composition and method of using the same for augmenting soft tissue is provided. The therapeutic filler composition may include an anti-microbial first component, a carrier, and a cross-linking agent, wherein the carrier is cross-linked with the cross-linking agent and the first component is combined with the cross-linked carrier into a combination having a therapeutic effect. | 2019-06-20 |
20190184065 | COMPOSITION COMPRISING HYALURONIC ACID AND MEPIVACAINE - A sterile composition for intraepidermal, intradermal, and/or subcutaneous administration including an effective amount of hyaluronic acid or a salt thereof, the effective amount of hyaluronic acid or salt thereof ranging from 1 to 3 wt % of the overall weight of the sterile composition, mepivacaine or a salt thereof as a first anesthetic agent at a concentration ranging from 0.05 to 3 wt % of an overall weight of the sterile composition, and a balanced salt solution in which the sterile composition exhibits greater stability over time and/or during heat treatment resulting in sterilization in comparison to the same composition having lidocaine as the anesthetic agent instead of mepivacaine. | 2019-06-20 |
20190184066 | ARTIFICIAL SKIN AND HUMAN PHANTOM FOR USE IN ACTIVE MILLIMETER WAVE IMAGING SYSTEMS - The present disclosure is directed to an artificial skin having a radar absorbing layer and a conductive layer containing an electrically conductive material, wherein the artificial skin has a reflection coefficient substantially equal to a human skin reflection coefficient, the human skin reflection coefficient being determined at an electromagnetic radiation frequency ranging from 1-500 GHz. A human phantom composed of the artificial skin and methods of testing the contrast resolution sufficiency of and active millimeter wave imaging system using the human phantom are also disclosed. | 2019-06-20 |
20190184067 | MODIFIED ALGINATES FOR ANTI-FIBROTIC MATERIALS AND APPLICATIONS - Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body. | 2019-06-20 |
20190184068 | ANTIMICROBIAL COMPOSITIONS COMPRISING MINOCYCLINE AND OXIDIZED CELLULOSE - Disclosed are compositions comprised of Oxidized Cellulose (OC), such as oxidized regenerated cellulose (ORC), and an antibiotic comprised of minocycline, methods of preparation thereof and uses thereof. | 2019-06-20 |
20190184069 | ANTIMICROBIAL COMPOSITIONS COMPRISING MINOCYCLINE AND DEGRADATION PRODUCTS OF OXIDIZED CELLULOSE - Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof. | 2019-06-20 |
20190184070 | System, Method, And Apparatus For Regulating Pressure - Subject matter relating to pressure regulation is described. In one illustrative embodiment, an apparatus for regulating pressure may include a supply chamber, a control chamber, and a charging chamber. The supply chamber may have a supply port adapted for coupling to a supply lumen, and the control chamber may have a control port adapted for coupling to a feedback lumen. The charging chamber can be fluidly coupled to the supply chamber through a charging port. A regulator valve within the control chamber can operate to control fluid communication through the charging port based on a differential between pressure in the control chamber and a target pressure. | 2019-06-20 |
20190184071 | FLOW RESTRICTOR FOR SURGICAL DEVICE - An apparatus, system and method for providing a flow restrictor suitable for inclusion in an aspiration flow of an ocular surgical device. The flow restrictor includes a conical valve head suitable for insertion into a valve stage, wherein, upon the insertion, the valve head at least substantially impedes the aspiration flow; a flexible spider membrane having a plurality of valve passages that open and close with the flexation of the membrane, wherein the membrane is connective with the valve head and forces the insertion of the valve head into the valve stage proportionally to the aspiration flow; a circular receiving plate for receiving the aspiration flow, wherein the circular receiving plate imparts the proportional insertion to the membrane; and a plurality of ribs integral to at least one of the valve head and the valve stage that provides a minimum for the aspiration flow when the insertion is full. | 2019-06-20 |
20190184072 | CASSETTE ANNUNCIATION - Systems for illuminating fluidic connectors on a surgical fluidics cassette without interfering with a fluid level detection system of a surgical console. | 2019-06-20 |
20190184073 | DIAPHRAGM VACUUM PUMP - A diaphragm vacuum pump has a pump chamber, a vacuum diaphragm for generating an underpressure in the pump chamber, an electric motor with a motor shaft, a gear and a connecting element. The gear converts a rotational movement of the motor shaft into a cyclical, approximately linear forward and rearward movement of the connecting element, as a result of which the connecting element effects a cyclical movement of the vacuum diaphragm. The rearward movement of the connecting element per cycle is effected by a first rotation angle of the motor shaft which, on account of the gear, is not of the same magnitude as a second rotation angle of the motor shaft, wherein the second rotation angle effects the forward movement of the connecting element per cycle. The diaphragm vacuum pump according to the invention can be designed such that it is small and quiet and yet provides optimal power. | 2019-06-20 |
20190184074 | Reduced-Pressure Wound Treatment Systems And Methods Employing Manifold Structures - Manifold structures, systems, and methods are disclosed that include using longitudinal members and one or more shaped projections to cause microstrain at a tissue site. In one instance a manifold structure includes a plurality of spaced longitudinal members and at least one shaped projection coupled to at least one of the plurality of longitudinal members for creating a microstrain at a tissue site. The at least one shaped projection includes a columnar member having a distal end and includes an enlarged member positioned at the distal end of the columnar member. The columnar member has a first outer diameter (D | 2019-06-20 |
20190184075 | WOUND DRESSING WITH INFLATABLE STRUCTURES - Disclosed is a contact layer for a negative pressure wound treatment system, in which the contact layer includes as inflatable channel with an opening for inflation or deflation of a fluid. The contact layer is flexible to be kept close to the intestines and to be possible to wrinkle or fold it in order to fit into the wound. To keep it in the desired position once this is achieved since the contact layer is thin and lacks rigidity and stability and may thus easily be dislocated, the contact layer allows the inflatable channel to be in an uninflated, or slightly inflated, state from the start to be able to easily wrinkle and fold the contact layer first and thereafter, during or after placing the contact layer in position, inflating the channel to increase the rigidity and stability to help to keep the contact layer in its desired position. | 2019-06-20 |
20190184076 | IMPROVEMENTS IN OR RELATING TO BLOOD SALVAGE AND AUTOTRANSFUSION - Apparatus for blood processing comprising a blood collection reservoir ( | 2019-06-20 |
20190184077 | SKIN INTERFACE DEVICE HAVING A SKIN ATTACHMENT DEVICE AND METHOD TO IMPLANT SAME - The present invention provides a skin attachment device for use with implantable medical devices which extend through the skin for prolonged durations. | 2019-06-20 |
20190184078 | PERCUTANEOUS HEART PUMP - Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes a resealable member. The heart pump can also include a diffuser disposed between the distal end of the catheter body and the impeller, wherein the diffuser includes a flow directing surface. | 2019-06-20 |
20190184079 | SYSTEM AND METHOD FOR CONTROLLING THE POSITION OF A LEVITATED ROTOR - A rotary machine is provided which may include a rotor and a stator within a housing. The stator may be for generating a rotating magnetic field for applying a torque to the rotor. A commutator circuit may provide a plurality of phase voltages to the stator, and a controller may adjust the plurality of phase voltages provided by the commutator circuit to modify an attractive force of the stator on the rotor to move the rotor in an axial direction. | 2019-06-20 |
20190184080 | DEVICE TO ASSIST THE PERFORMANCE OF A HEART - In a catheter ( | 2019-06-20 |
20190184081 | ARTIFICIAL HEART - Disclosed herein is a fully implantable artificial heart. The use of flat helical springs to align and reciprocate a bellows structure allows the bellows to pump blood, the multiple solenoids with floating magnetized rods and permanent magnet assemblies held by the flat helical springs provide the power. The artificial heart pumps blood with virtually no friction and no parts to wear out. The use of solenoids advantageously move blood in a gentle, controllable manner. | 2019-06-20 |
20190184082 | HEART RATE MEASUREMENT USING BLOOD PUMP IMPELLER LOCATION - A method of determining a heart rate of a patient having an implanted blood pump including applying a voltage to a plurality of coils of a stator of the blood pump to produce an electromagnetic force to rotate a rotor in communication with the plurality of coils; displaying a waveform associated with a back electromotive force in the plurality of coils of the blood pump, the waveform being proportional to an axial position of the rotor relative to the stator; determining a time interval between a first alteration in the waveform relative to a baseline and a second alteration in the waveform relative to the baseline; and determining the heart rate of the patient based on the time interval. | 2019-06-20 |
20190184083 | VENA-CAVAL SLEEVE - Apparatus and methods are described for use with a tributary vessel of a subject that supplies a vein of the subject. Blood within the tributary vessel is mechanically isolated into a compartment that is separated from blood within the vein. Blood flow from the tributary vessel to the vein is controlled by pumping blood from the compartment to the vein. Other applications are also described. | 2019-06-20 |
20190184084 | DIALYZER AND FABRICATING METHOD THEREOF - A dialyzer and a fabricating method thereof are provided. The dialyzer includes a housing, a hydrophilic layer, a fixing layer, a plurality of hollow fiber membranes, and two end caps. The housing has a first opening and a second opening, and is provided with a dialysate inlet and a dialysate outlet, wherein an entire peripheral surface of the housing located between the first opening and the dialysate inlet is a first portion, and an entire peripheral surface of the housing located between the second opening and the dialysate outlet is a second portion. The hydrophilic layer is disposed on the inner wall of the first portion and the second portion, wherein the hydrophilic layer and the housing are different materials. The fixing layer is disposed on the hydrophilic layer and fixes the hollow fiber membranes to the inner wall of the housing. | 2019-06-20 |
20190184085 | END CAP OF DIALYZER AND FABRICATING METHOD THEREOF, AND DIALYZER - An end cap of a dialyzer and a fabricating method thereof, and a dialyzer are provided. The end cap includes a main body and a sealing element. The main body has a blood port. The sealing element is integrally connected on an inner wall of the main body. | 2019-06-20 |
20190184086 | Bioartificial Liver - This document provides bioartificial liver (BAL) devices. Methods for making and using BAL devices also are provided. | 2019-06-20 |
20190184087 | SYSTEM AND METHOD OF COLLECTING AND INFUSING AN APOPTOTIC WHITE BLOOD CELL COMPONENT AND A TRANSPLANT COMPONENT - A method for prophylaxis or treatment of a graft's rejection of a recipient, driven and adjusted by a microprocessor-based controller. Provided is a fluid circuit comprising a first container configured to receive a transplant component and a second container configured to receive an apoptotic component. Provided is a separator configured to associate with the fluid circuit and separate whole blood into a red blood cell component, a plasma component, and a white blood cell component. Whole blood is directed into the fluid circuit and the separator. The whole blood is separated into the red blood cell component, the plasma component, and the white blood cell component. A first portion comprising the transplant component of the white blood cell component is directed to the first container. A second portion of the white blood cell component is directed to the second container and the second portion is rendered apoptotic. | 2019-06-20 |
20190184088 | Nasal Irrigation Apparatus and Kit - An apparatus for nasal irrigation comprising a resiliently compressible bottle component and a spout having a proximal end for demountable engagement with the bottle component. The distal end of the spout may be molded for sealable engagement with a user's nostril. Alternatively, the distal end of the spout may be threaded for demountable sealable engagement with a nasal tip molded for sealable engagement with a user's nostril. The tip may be configured for delivering a solution in the form of a stream, or a spray, or a misting. A kit comprising the nasal irrigation apparatus and one or more selected volumes of one or more nasal irrigation solutions. The kit may additionally comprise one or more nasal tips. The nasal irrigation solution may comprise one or more of an antibiotic, an antihistamine, a steroid, a vasoconstrictor, an emollient, and an ion. | 2019-06-20 |
20190184089 | INSULATED AUTO-INJECTOR CONTAINER - An insulated, soft, durable fabric pouch sized and adapted to hold one or more epinephrine auto-injectors, or insulin injectors, the pouch including preferably a gel type insulation surrounding at least a major part of the injector(s), a rapid-opening top flap to facilitate immediate and easy availability of the injector for grasping and using by the user. | 2019-06-20 |
20190184090 | SYRINGE PACKAGE - A syringe package contains a prefilled syringe system including a prefilled syringe that includes a syringe body that is filled with a drug, a gasket located in the syringe body, and a plunger partially disposed in the syringe body. The syringe package includes: a package body that houses the prefilled syringe; and a support that is disposed inside the package body and that supports the prefilled syringe. The support includes a displacement regulation unit configured to regulate relative displacement of the syringe body and the plunger in a direction in which the gasket and the plunger approach each other. | 2019-06-20 |
20190184091 | MEDICINE INJECTION AND DISEASE MANAGEMENT SYSTEMS, DEVICES, AND METHODS - Diabetes management systems may include a glucose monitoring device adapted to transmit glucose data and at least one accessory in communication with the glucose monitoring device and adapted to provide at least one alarm or alert based on the glucose data. | 2019-06-20 |
20190184092 | PEN CAP FOR INSULIN INJECTION PENS AND ASSOCIATED METHODS AND SYSTEMS - One or more embodiments of the disclosure relate, generally, to a pen cap for a manual insulin delivery device. Such a pen cap may include a wireless communication interface, a detection circuit, a user interface, and a processor and memory. The detection circuit may be configured to detect cappings and decappings of the pen cap from a manual insulin delivery device. Timing information and recommendations related to capping and decapping of the pen cap may be presented to a user. | 2019-06-20 |
20190184093 | DEVICES, SYSTEMS, AND METHODS FOR ESTIMATING ACTIVE MEDICATION FROM INJECTIONS - One or more embodiments relate, generally, to a reusable accessory for a medication injection pen. Such a reusable accessory may be adapted to be reversibly attached to a medication injection pen, and configured to detect an event associated with an injection of medication from the medication injection pen. It may also be configured to determine a percentage of medication that remains active for injection by the medication injection pen based on timing information and dosing event information. | 2019-06-20 |
20190184094 | ALARMS AND ALERTS IN DIABETES MANAGEMENT SYSTEM - One or more embodiments of the disclosure relate, generally, to a therapy management system including signaling outputs to present alarms, alerts, and/or notifications discernable by a user. A glucose sensor system may wirelessly transmit blood glucose data to a reusable accessory adapted to be reversibly connectable to an insulin injection pen or other insulin delivery device. A mobile device may control the signaling outputs to present the alarms, alerts, and/or notifications based, at least in part, the blood glucose data. | 2019-06-20 |
20190184095 | ELECTROOSMOTIC PUMP - The present invention discloses a path-type liquid medicine delivery electro-osmosis pump that can be applied to a wearable medicine device. | 2019-06-20 |
20190184096 | INFUSION POUCH SET WITH BUILT-IN INJECTION MEDICINE BOTTLE HAVING VIAL FUNCTION - An infusion pouch set with a built-in injection medicine bottle having a vial function including: a discharge port | 2019-06-20 |
20190184097 | INTRAOSSEOUS NEEDLE ASSEMBLY AND METHOD OF USE THEREOF - An intraosseous needle assembly includes a needle having a first cylindrical shaft. The shaft having a distal end, a proximal end, and a wall defining an inner channel. The first cylindrical shaft includes threading protruding from the wall along a proximal portion of the first cylindrical shaft. The needle further includes a needle head extending from the proximal end of the first cylindrical shaft. The needle assembly may further include a stylet, the stylet having a second cylindrical shaft having a first end and a second end and a stylet head extending from the second end. The stylet head includes a proximal surface and a distal surface, a pair substantially parallel second side walls, a pair of rounded end sections joining the second side walls, a protrusion extending from the distal surface, and a tapered section extending from the distal surface to the second cylindrical shaft. | 2019-06-20 |
20190184098 | DEVICE FOR MEASURING A FILL LEVEL OF A FLEXIBLE MEDICINE RESERVOIR - The invention concerns a device ( | 2019-06-20 |
20190184099 | FLOW DETECTOR - Disclosed is a flow detector ( | 2019-06-20 |
20190184100 | Method of and Apparatus for Performing Intravenous Drip Injection - A method of performing an intravenous drip injection includes a first step, a second step, a third step and a fourth step. A first step includes starting dosing an infusion solution containing a predetermined component by the intravenous drip injection to a dosing recipient. A second step includes extracting a body fluid from the dosing recipient being dosed with the infusion solution. A third step includes measuring a concentration of the predetermined component in the extracted body fluid. A fourth step includes varying the concentration of the predetermined component in the infusion solution, corresponding to the concentration of the predetermined component in the body fluid. | 2019-06-20 |
20190184101 | INJECTION DEVICE - An injection device comprising: a housing arranged to contain a syringe with a piston for sealing the syringe and displacing the medicament, the housing having a proximal end and a distal end, wherein the distal end is intended to be applied against an injection site; a driving mechanism arranged between the piston and the proximal end of the housing; and a locking mechanism comprising a plate member arranged between the driving mechanism and the piston to retain the driving mechanism to retain the driving mechanism in an initial inactive state in which the driving mechanism cannot be actuated; wherein when the locking mechanism is released, the driving mechanism can be actuated to push the piston towards the distal end of the housing to displace the medicament. | 2019-06-20 |
20190184102 | ADMINISTRATION APPARATUS - An administration apparatus includes an apparatus body, a syringe portion, a piston portion, an ignition device and a sealing member formed of a metal plate-like member. The sealing member separates a space in the apparatus body into a first space where the ignition device is disposed and a second space where the piston portion is disposed, and seals a combustion product generated by the ignition device in the first space. A peripheral edge portion of the sealing member is fixed to an inner wall that defines the space. The sealing member is deformed by the gunpowder combustion such that its central portion is displaced to a side of the piston portion, to thereby press the piston portion against the plunger using the central portion. With this, the generated combustion product is prevented to be administered, and energy for administration is suitably transmitted to the substance to be administered. | 2019-06-20 |
20190184103 | APPARATUS AND METHOD FOR NEUTRALIZING LOCAL ANESTHETIC - The present disclosure relates to devices and methods for neutralizing an acidic anesthesia solution. An anesthesia neutralization device includes an outer housing and an inner housing. The inner housing holds a buffer carpule and an anesthetic carpule in a side by side arrangement, with the buffer solution maintained under pressure prior to deployment. A curved transfer needle is coupled to the outer housing and includes ends that both point respectively toward the buffer carpule and anesthetic carpule. The device is actuated by moving the inner housing relative to the outer housing to bring the anesthesia carpule and buffer carpule into contact with the transfer needle and to force buffer solution through the transfer needle and into the anesthesia carpule. | 2019-06-20 |
20190184104 | Housing for an Injection Device - The present invention relates in one aspect to a housing for an injection device, comprising: —a body ( | 2019-06-20 |
20190184105 | NEEDLELESS INJECTOR - A needleless injector includes a main body, a syringe portion, a piston portion, an igniting device, and a pressing member. The pressing member is formed so as to have a part displaceable toward the piston portion while the part being kept from returning to the igniting device side upon receiving the ejection energy from the igniting device, and presses the piston portion toward the plunger based on displacement of the part. In addition, while the piston portion is pressed by the pressing member, the elastically deformable part is partly or entirely recovered from the elastic deformation from a most compressed state by the pressing force received from the pressing member so as to push the output portion toward the plunger. Accordingly, the injector achieves efficient ejection of the injection objective substance in order to deliver the injection objective substance to an injection target area while the injector is designed compact. | 2019-06-20 |
20190184106 | Slanted Syringe Handle - Example syringe handles including a hub portion and a grip portion. The hub portion includes an outer surface, an inner surface configured to receive a portion of a syringe body, and a top and bottom surface each being adjacent to both the outer surface and the inner surface. The grip portion includes a first and a second arm, each connected to and extending from the outer surface of the hub portion. The first arm includes a distal end biased toward the top surface of the hub portion and the second arm includes a distal end biased toward the top surface of the hub portion. | 2019-06-20 |
20190184107 | THERAPY ASSIST INFORMATION AND/OR TRACKING DEVICE AND RELATED METHODS AND SYSTEMS - A monitoring feature, such as, for example, a pen cap, for an insulin delivery device may include at least one circuit adapted to detect at least one of a capping or decapping of the pen cap from an insulin pen and a processor for using information to the at least one of a capping or decapping of the pen cap. A monitoring feature for an insulin delivery device includes at least one circuit adapted to detect use of the insulin delivery device. | 2019-06-20 |
20190184108 | INSULIN INJECTION ASSISTANCE SYSTEMS, METHODS, AND DEVICES - One or more embodiments of the disclosure relate, generally, to a system to assist with manual dosing of insulin. Such a system may include a glucose sensor system, a reusable insulin dosing detector, and a recommendation system. The reusable insulin dosing detector may be configured to be reversibly connectable to a disposable component that may form part of an insulin manual delivery assembly. The reusable insulin dosing detector may be configured to detect insulin delivery associated with the insulin manual delivery assembly. The recommendation system may be configured to analyze blood glucose data and determine adjustments to insulin therapy settings. | 2019-06-20 |
20190184109 | THERAPY MANAGEMENT SYSTEMS, METHODS, AND DEVICES - One or more embodiments of the disclosure are related, generally, to a reusable accessory for a manual medication delivery device. Such a reusable accessory may include a wireless communication interface, a detection circuitry, and a recommendation system. In one or more embodiments, an adapter may be configured to reversibly couple such a reusable accessory to a manual medication delivery device. Dosing events may be detected that are associated with dosing at the manual medication delivery device. Dose recommendations may be provided responsive to analyte measurements and/or dosing events. | 2019-06-20 |
20190184110 | READING DEVICE, DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE IN COMBINATION WITH A READING DEVICE - The disclosure provides a reading device ( | 2019-06-20 |
20190184111 | PEN CAP FOR MEDICATION INJECTION PEN HAVING TEMPERATURE SENSOR - One or more embodiments of the disclosure relate, generally, to a replacement pen cap for a medication injection pen comprising at least one temperature sensor for monitoring a temperature of a medication, detect dosing events, and determine that medication may be denatured based on temperature data, received analyte measurement data prior, and the detected dosing events. | 2019-06-20 |
20190184112 | Means and method to give injections with little or no pain - A preferred method to obtain a painless or near painless needle | 2019-06-20 |
20190184113 | Assistive Device for Subcutaneous Injections or Implants - An assistive device for subcutaneous injections or implants. The assistive device is placed under a blood pressure cuff that displaces the skin and subcutaneous tissues of a patient at an insertion site in order to allow guided insertion of a needle or implant applicator into a subcutaneous fat layer. The skin and subcutaneous tissue is displaced or drawn, via pressure applied by the blood pressure cuff, through an injection window of a device body into a hollow cavity of the device body. A guide channel leads from a front side of the device body into the hollow cavity, and an applicator of an adapter is inserted through the guide channel into the subcutaneous fat layer. | 2019-06-20 |
20190184114 | DRY-POWDER INHALATION DEVICE - An improved dry-powder inhalation device having a casing having an air inlet located at a first terminus; a powder delivery port located at a second terminus, which is positioned distal to the air inlet; and an elongated support panel located within an interior of the casing and being fitted within the casing so as to partially rotate therein about a single axis. The casing has at least one compartment containing dry-powder located proximally to the second terminus, and the support panel has a plurality of needle-like structures located proximal to the delivery port and arranged opposite the dry-powder compartment. The compartment with a dry-powder includes a cover encasing the dry-powder, whereby airflow through the device causes the elongated support panel to partially rotate repeatedly within the casing, whereby the plurality of needle-like structures strike the covered compartment, causing the dry-powder to be released into the airflow. | 2019-06-20 |
20190184115 | NASAL RINSING CAP FOR BOTTLES - Cap for bottle for rinsing nose, suitable for standard water bottle. The device comprises a body portion to be attached to the top of the bottle, comprising a cylindrical void for the threaded portion of the bottle, and one-way fluid valve attached to a void extending from the cylindrical void through the body portion. The body portion also includes one-way air valve to allow the entry of air into the bottle because of the negative pressure in it. A top portion is removably or openably attached to the body portion, comprising tubular opening starting near the body portion and extending through the top portion, wherein the top portion is configured so that it has a tip to be contacted with the user's nasal cavities and the top portion has as pressure zone for closing the fluid fluid valve by applying a pressure to said pressure zone. | 2019-06-20 |
20190184116 | SYSTEMS AND METHODS FOR INTELLIGENT GAS SOURCE MANAGEMENT AND/OR SYSTEMS AND METHODS FOR DELIVERY OF THERAPEUTIC GAS AND/OR ENHANCED PERFORMANCE VERIFICATION FOR THERAPEUTIC GAS DELIVERY - Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display. | 2019-06-20 |
20190184117 | BREATHING BAG, SYSTEM COMPRISING A BREATHING BAG AND A DISPENSING VALVE UNIT, CLOSED-CIRCUIT RESPIRATOR AS WELL AS PROCESS FOR MOUNTING A SYSTEM COMPRISING A BREATHING BAG AND A DISPENSING VALVE UNIT IN A CLOSED-CIRCUIT RESPIRATOR - A breathing bag ( | 2019-06-20 |
20190184118 | INTERACTIVE GUIDANCE RELATED TO A SUBJECT'S EXPIRATORY FLOW LIMIATION RESULTS - In certain embodiments, a ventilator may provide interactive guidance for obtaining a subject's expiratory flow limitation results. In some embodiments, the ventilator may cause a progressive color component to be presented, where the progressive color component indicates a progression from one color proximate one side of the progressive color component to another color proximate another side of the progressive color component. The ventilator may cause a forced oscillation to be continuously applied to an airway of the subject for a time period. The ventilator may monitor the subject's degree of expiratory flow limitation based on output signals generated by one or more sensors as the forced oscillation is continuously applied for the time period. The ventilator may cause, based on the monitoring, a movable component's position on the progressive color component to be continuously updated during the time period to indicate the degree of expiratory flow limitation. | 2019-06-20 |
20190184119 | MULTIPLE CONTROL INTERFACE FOR MEDICAL VENTILATOR - Examples described herein include multiple control systems for medical devices, such as medical ventilators. Examples of multiple control of a medical ventilator in an isolation room are described. | 2019-06-20 |
20190184120 | Tracheal Tube and Method of Production - It is the object of the invention, which relates to a tracheal tube ( | 2019-06-20 |
20190184121 | METHOD FOR OBTAINING FACIAL METRICS OF A PERSON AND INDENTIFYING A MASK FOR THE PERSON FROM SUCH METRICS - A method of determining facial metrics of a person includes: receiving a request that the person requires a mask; navigating an autonomously operable vehicle to the person using at least one imaging device; capturing a number of images of the person using the at least one imaging device; and determining facial metrics of the person from the number of images. The method may be further employed in a method for identifying a mask for the person which further includes determining a mask for the user from the facial metrics; and identifying the mask to the person. | 2019-06-20 |
20190184122 | DETERMINING FACIAL METRICS OF A PATIENT AND IDENTIFYING A CUSTOM MASK FOR THE PATIENT THEREFROM - A method of determining facial metrics of a patient includes: capturing a first image of the patient with an image capturing device positioned in a first known position with the assistance of a positioning device, capturing a second image of the patient with the image capturing device positioned in a second known position different that the first known position with the assistance of the positioning device, and determining facial metrics of the patient by analyzing the first image and the second image. | 2019-06-20 |
20190184123 | GROUNDING POSITIVE AIRWAY PRESSURE MASKS AND HEADGEAR - An interface device for delivering a flow of a treatment gas to an airway of a patient includes: a conductive element positioned on a surface such that the conductive element directly contacts the patient when the interface device is positioned on the patient for delivering the flow of the treatment gas to the airway of the patient; and a conductive pathway extending from a first end which is electrically connected to the conductive element to an opposite second end which is structured to be electrically connected to earth ground. | 2019-06-20 |
20190184124 | POSITIVE-AIR-PRESSURE MACHINE CONDUIT - A conduit for delivering a supply of gas under a positive pressure includes a conduit wall having a first conduit end and a second conduit end. The first conduit end is adapted to be attached to the supply of gas. The conduit wall is deformable between (a) an open condition in which the conduit wall defines a conduit passage along which the supply of gas can travel between the first conduit end to the second conduit end, and (b) a collapsed condition in which the conduit wall substantially collapses the conduit passage. | 2019-06-20 |
20190184125 | POSITIVE-AIR-PRESSURE MACHINE CONDUIT - A conduit for delivering a supply of gas under a positive pressure includes a conduit wall having a first conduit end and a second conduit end. The first conduit end is adapted to be attached to the supply of gas. The conduit wall is deformable between (a) an open condition in which the conduit wall defines a conduit passage along which the supply of gas can travel between the first conduit end to the second conduit end, and (b) a collapsed condition in which the conduit wall substantially collapses the conduit passage. | 2019-06-20 |
20190184126 | FACE MASK - A mask assembly is provided for delivering gas to a patient that includes a mask body and a breathing circuit interface. The mask body includes an opening for reception of the gas and includes a seal structure for sealingly engaging with the face of the patient and surrounding at least the nose and mouth of the patient. The breathing circuit interface includes a first portion rotatably connected with the mask body and a second portion that is constructed and arranged to releasably connect with a conduit for delivering the gas to the patient through the opening. | 2019-06-20 |
20190184127 | LOCKING TUBE CLIP - A component useable with one or more tube comprises a body engageable with one or more external surface recesses of the one or more tubes. The component has a pair of jaws extending from the body for gripping an item. The component is configured, such that, in use, in a first orientation of the body relative to the respective tube(s) recesses, the component is movable along a length of the tube(s); and, in a second orientation of the body relative to the respective tube(s) recesses, the component is resistive to movement along a length of the tube(s). | 2019-06-20 |
20190184128 | PORTABLE OXYGEN CONCENTRATOR FOR RECREATION AND HIGH ALTITUDE SPORTS - This disclosure relates to a portable oxygen concentrator system. The system includes a case containing a portable oxygen concentrator, a mask, and a button. The case is configured to be worn on a user's back. The mask is configured to deliver oxygen from the portable oxygen concentrator to the user. The button, when activated, is configured to cause the portable oxygen concentrator to deliver an increased flow of oxygen to the user for a period of time. | 2019-06-20 |
20190184129 | SYSTEM AND METHOD FOR CONTROLLING CONDUIT HEATING - A pressure support system for delivering a flow of breathing gas to an airway of a patient includes a base unit structured to generate the flow of breathing gas and including a heating control unit, a conduit coupled to the base unit and structured to carry the flow of breathing gas, a thermistor disposed in the conduit, and first and second resistive wires extending along the conduit from the base unit to the thermistor. The heating control unit is structured to selectively operate in a first mode to heat the conduit using the first and second resistive wires and a second mode to sense a temperature of airflow in the conduit with the thermistor via the first and second resistive wires. | 2019-06-20 |
20190184130 | AUGMENTED REALITY THERAPY FOR TREATING MENTAL HEALTH AND DEVELOPMENTAL DISORDERS - Methods and systems for using augmented reality (AR) technology in the mental health/developmental disorder treatment field. More particularly, methods and systems for providing a mental health/developmental disorder treatment service, process and system that introduces an input of a licensed healthcare professional into a patient's field of vision while he or she is utilizing a wearable medical device or wearable device. | 2019-06-20 |
20190184131 | METHODS FOR ENHANCING EXPOSURE THERAPY USING PAIRING WITH VAGUS NERVE STIMULATION - Disclosed is a method of enhancing exposure therapy including providing an exposure therapy to a patient and stimulating the patient's vagus nerve at the same time as the exposure therapy. Also disclosed is a post-traumatic stress disorder therapy method including providing an exposure event to a patient and stimulating the patient's vagus nerve during the exposure event. Also disclosed is a phobia disorder therapy method including providing an extinction event to a patient and stimulating the patient's vagus nerve during the exposure event. Also disclosed is an obsessive compulsive disorder therapy method including providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event. Also disclosed is an addiction disorder therapy method including providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event. | 2019-06-20 |