24th week of 2022 patent applcation highlights part 41 |
Patent application number | Title | Published |
20220187208 | SURFACE-BASED LUMINESCENCE MEASUREMENT SUBSTRATE - Surface-based measurement substrate including:
| 2022-06-16 |
20220187209 | IN SITU MEASUREMENT OF ABSOLUTE CONCENTRATIONS BY NORMALIZED RAMAN IMAGING - A method for measuring a composition of a biological sample is disclosed. A stimulated Raman scattering (SRS) image of the biological sample is received. The effect of light scattering in the received SRS image is computationally removed. An absolute concentration of total protein, total lipid, and/or water from the biological sample is determined. | 2022-06-16 |
20220187210 | METHOD FOR EXPRESSING NUMERICAL INFORMATION - A method for expressing multiple types of numerical information using the features of SERS-active nanostructures is disclosed. The method includes: associating a SERS signal with numerical information; applying, to one or more positions a, b, d on a physical object e, nanotags including an aggregate of noble metal nanoparticles with an average diameter of 100 nm or less and a Raman-active chemical substance; irradiating the applied nanotag with a laser; reading the SERS signal generated by the irradiation; and acquiring the numerical information from the read SERS signal on the basis of the association. The nanotags derive from one or more types of nanotag ink A, B, D (FIG. | 2022-06-16 |
20220187211 | APPARATUS INCLUDING ANALYZER UNIT - There is provided an apparatus including a chip containing metal bodies capable of exciting localized surface plasmon resonance at a first surface, and an analyzer unit that performs a scan of the first surface of the chip, in a state where the first surface is in contact with a sample, with a laser in at least a one-dimensional direction and records scattered light, which has been enhanced at the first surface, in association with the scan. The chip includes a substrate, a first layer where concave and convex structures are repeatedly provided on the first surface of the substrate; and a second layer that contains the metal bodies and is provided via the first layer. | 2022-06-16 |
20220187212 | PLASMA SOURCE CHAMBER FOR A SPECTROMETER - A plasma source chamber ( | 2022-06-16 |
20220187213 | Method and Apparatus for Rapid Virus Screening and Detection using a Canine - A medical swab comprising a thin stick comprising a drawn plastic stick and a sphere-like fiber lump formed on at least one end of the stick. The fibers are chemically treated to enabled a color change when exposed to moisture. On the thin stick, a unique identifier sticker or tab is placed on the swab. A cover is slidably attached and there is a slide stop located near the head or collection area. The cover has an egg shape and split design where the cover is comprised of two equally sized pieces connected by a small hinge portion. The cover has a plurality of holes which allow odor to escape from the cells or material collected on the swab. When in the closed position the clips act as a clasp, which locks the cover in place, creating a cage around the head or sample end. | 2022-06-16 |
20220187214 | ASSAY READER OPERABLE TO SCAN A TEST STRIP - Low-cost assay test strip readers are disclosed. Such readers enable creation of profiles of analyte reactions detected on an assay test strip utilizing a simple detector fixedly mounted to a body of the reader. The detector may be a single detector, such as a photodetector, which detects an optical signal at a single point. The assay test strip is inserted and/or removed from the test strip reader and the detector detects the optical elements of the strip during such insertion and/or removal. The movement of the test strip with respect to the body enables the detector to scan a length of the test strip, such that a one-dimensional profile of the optical signals can be generated. The reader may convert the detected profile into a displayable indication of analyte concentrations for diagnostic purposes. Moving the test strip relative to an array of detectors enables creation of a two-dimensional profile. | 2022-06-16 |
20220187215 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND RECORDING MEDIUM - An apparatus according to the present disclosure acquires a display condition for displaying at least a part of target data as a display image on a display device, determines, in a case where the display image is changed, whether to store the display condition according to a changed display image in a storage device, based on an index relating to the change of the display image, and stores, in a case where the display condition is determined to be stored, the display condition according to the changed display image in the storage device. | 2022-06-16 |
20220187216 | METHOD AND APPARATUS FOR MONITORING EDGE BEVEL REMOVAL AREA IN SEMICONDUCTOR APPARATUS AND ELECTROPLATING SYSTEM - A semiconductor apparatus includes a transfer chamber, an annealing station, a robot arm, an edge detector and a trigger device. The transfer chamber is configured to interface with an electroplating apparatus. The robot arm is arranged to transfer a wafer from the transfer chamber to the annealing station. The edge detector, disposed over a predetermined location between the transfer chamber and the annealing station, comprises a first charge-coupled device (CCD) sensor and a second CCD sensor. When the robot arm is carrying the wafer to pass through the predetermined location, the first CCD sensor and the second CCD sensor are located over a first portion and a second portion of the edge bevel removal area respectively, and the trigger device is configured to activate the first CCD sensor and the second CCD sensor to capture an image of the first portion and an image of the second portion respectively. | 2022-06-16 |
20220187217 | SYSTEM AND METHOD FOR DETECTING GLASS-CERAMIC MATERIAL - An automated system for detecting glass-ceramic materials among a cullet, includes at least one white light source and at least one monochromatic ultraviolet light source, each being oriented to emit in the same emission region. The system includes an image acquisition device configured to acquire an image of the emission region and an image processing device configured to process each of the images acquired by the image acquisition device, the image processing device including a colorimetric image processing module configured to ensure the detection of the glass-ceramic material among othertypes of glass. | 2022-06-16 |
20220187218 | ANGLE INDEPENDENT OPTICAL SURFACE INSPECTOR - An angle independent optical surface inspector capable of generating a light beam, directing the light beam to a sample, and de-scanning a reflected light beam that is reflected from the sample, thereby generating a first de-scanned light beam. The de-scanning is performed at approximately one focal length of a de-scanning lens from an irradiation location where the light beam irradiates the sample. The optical inspector also capable of focusing the first de-scanned light beam, thereby generating a focused light beam, and measuring the location of the focused light beam. The measuring of the location is performed at approximately one focal length of a focusing lens from the focusing lens. The incident angle of the light beam is within ten degrees of Brewster's angle. The focusing is performed by an achromatic lens. | 2022-06-16 |
20220187219 | APPARATUS TO DIRECTLY DETECT SOLIDS FORMATION - An apparatus to directly detect solids formation in a fluid under known pressure and temperature conditions is disclosed. The apparatus includes a vessel having an electromagnetic resonant cavity defined by an upper portion, a lower portion and a gap defined therebetween, the gap having resonant properties sensitive to the presence of a solid phase therein. The upper portion or the lower portion may be provided with a passage extending therethrough in fluid communication with an inlet to allow ingress of a stream of fluid to the gap and thereby purge solids from the cavity subsequent to solids formation. | 2022-06-16 |
20220187220 | MEASURING A WATER CUT OF HYDROCARBON FLUID IN A PRODUCTION PIPE - The present disclosure describes methods and systems, including computer-implemented methods, computer program products, and computer systems, for measuring a water cut for hydrocarbon fluid in a production pipe. One method includes transmitting a microwave through a first waveguide attached to a production pipe, wherein the microwave is directed to the hydrocarbon fluid in the production pipe; and obtaining, measurement results based on reflection or propagation of the microwave, wherein the measurement results are used to determine a water cut of the hydrocarbon fluid. | 2022-06-16 |
20220187221 | MEASUREMENT SYSTEM AND METHOD FOR OPERATING A MEASUREMENT SYSTEM - A method for operating a measurement system ( | 2022-06-16 |
20220187222 | SECURITY SCREENING DEVICE CAPABLE OF DETECTING AND LOCATING DANGEROUS OBJECTS BY USING RADIATION - The present invention relates a security screening device, comprising: a radiation generator for respectively generating X-rays and neutron beams and irradiating same toward an inspection object; an inspection object transfer unit for changing the position of the inspection object; a radiation detector configured to respectively detect X-rays and neutron beams transmitted through the inspection object; and a gamma ray detector installed adjacent to the inspection object and configured to detect a gamma signal generated from the inspection object, wherein the radiation detector acquires image information of the inspection object by using radiation information detected from the X-rays and neutron beams that have passed through the inspection object, and the gamma ray detector analyzes the detected gamma ray to detect the location of the inspection object from the analysis of the inspection object and the image information. | 2022-06-16 |
20220187223 | METHOD AND SYSTEM FOR EVALUATING ROTOR-MAST FATIGUE DAMAGE - A method of evaluating fatigue damage of a rotor mast. The method includes performing an x-ray diffraction (“XRD”) inspection of the rotor mast, assessing fatigue damage sustained by the rotor mast based on results of the XRD inspection, and determining whether the rotor mast is suitable for continued use based on the assessed fatigue damage. | 2022-06-16 |
20220187224 | SAMPLE MOUNTING SYSTEM FOR AN X-RAY ANALYSIS APPARATUS - The sample mounting system comprises a sample holder and a sample stage having a platform for supporting the sample holder. The sample can be fixed to the sample holder by a mount. The sample holder comprises a holder reference portion, which co-operates with a corresponding reference portion of the sample stage (the stage reference portion) to align the sample holder with the sample stage. When the sample holder is positioned on the platform such that the stage reference portion and the holder reference portion engage each other, the sample holder is aligned with the sample stage. | 2022-06-16 |
20220187225 | METHOD AND DEVICE FOR ANALYZING DIFFRACTIONPATTERN OF MIXTURE, AND INFORMATION STORAGE MEDIUM - Provided is a method of analyzing a diffraction pattern of a mixture, the method including: a first step of fitting, through use of a fitting pattern including a term obtained by multiplying a known target pattern indicating a target component by a first intensity ratio, and a term obtained by multiplying an unknown pattern indicating a residual group consisting of one or more residual components by a second intensity ratio, and having the first intensity ratio, the second intensity ratio, and the unknown pattern as fitting parameters, the fitting pattern to the observed pattern by changing the first and the second intensity ratio in a state where the unknown pattern is set to an initial pattern; and a second step of fitting the fitting pattern to the observed pattern by changing the unknown pattern while restricting the changes of the first and the second intensity ratio. | 2022-06-16 |
20220187226 | A SYSTEM AND METHOD FOR DIFFRACTION-BASED STRUCTURE DETERMINATION WITH SIMULTANEOUS PROCESSING MODULES - A diffraction system for determining a crystalline structure of a sample collects a series of diffraction frames from a crystal sample illuminated by a beam of photonic or particulate radiation, such as X-rays. A plurality of software modules for processing the detected diffraction frames perform different tasks in refining the collected diffraction data, such as harvesting, indexing, scaling, integration, and structure determination. Output parameters from certain modules are used as input parameters in others, and are exchanged between the modules as they become available. The modules operate simultaneously, and generate successive versions of output parameters as corresponding input parameters are changed until a final result is achieved. This provides a system of structure determination that is fast and efficient. | 2022-06-16 |
20220187227 | METHOD OF ESTIMATING A MINERAL CONTENT OF A GEOLOGICAL STRUCTURE - A method of estimating a mineral content of a seabed geological structure is provided wherein there is provided at least one geophysical parameter of the geological structure. The method includes inverting the at least one geophysical parameter to estimate the mineral content of the geological structure. | 2022-06-16 |
20220187228 | CHARGED PARTICLE BEAM DEVICE, COMPUTER, AND SIGNAL PROCESSING METHOD FOR CHARGED PARTICLE BEAM DEVICE - A charged particle beam device includes a detector | 2022-06-16 |
20220187229 | ELECTROMAGNET FOR A THERMOGRAPHY SYSTEM - An electromagnet for a thermography system comprising a first elongated magnetic core spaced apart from a second elongated magnetic core; at least a first shorting bar connecting substantially at a first end of the first elongated magnetic core and a first end of the second elongated magnetic core; and at least a first excitation coil configured to conduct electrical current. | 2022-06-16 |
20220187230 | Methods and Systems for Determining a Target Gas Concentration in a Fluid Environment - A system and method of determining a target gas concentrations in a fluid environment using a gas sensor that improves the efficiency and accuracy of the gas sensor's measurements by taking measurements of electrical characteristics of the gas sensor at different temperatures, taking measurements during a transition between a first temperature and a second temperature, taking more frequent measurements, detecting when the gas sensor has reached equilibrium, using multiple sensors, accounting for offsets and drifts, reducing the time the sensor is not live, using various algorithms, or any combination thereof. | 2022-06-16 |
20220187231 | HYDROGEN SULFIDE SENSOR AND ASSOCIATED METHODS - A hydrogen sulfide sensor includes a substrate, a par of interdigitated electrodes disposed on the substrate, and a homogeneous polyaniline sensing film disposed on the pair of interdigitated electrodes and having electrical conductivity that depends upon a concentration of hydrogen sulfide. A method for detecting hydrogen sulfide includes for each sensor of a plurality of sensors: generating a signal if said sensor is exposed to a sample of hydrogen sulfide having density greater than or equal to a hydrogen sulfide detection threshold of said sensor, wherein the plurality of sensors has a respective plurality of hydrogen sulfide detection limits that span a detection range. A method for forming a hydrogen sulfide sensor includes dissolving a polyaniline polymer and a metal-chloride salt in an organic solvent to form a solution, and spin-coating the solution to form a homogeneous sensing film disposed on a pair of interdigitated electrodes disposed on a substrate. | 2022-06-16 |
20220187232 | GAS SENSOR AND METHOD OF SELECTIVELY DETECTING ACETYLENE AND ETHYLENE - A gas sensor that selectively detects and/or measures acetylene and/or ethylene includes a substrate; at least one electrode pair; at least one gas-sensitive layer consisting of at least one metal oxide from the group ReFeO | 2022-06-16 |
20220187233 | GAS ADSORBENT, GAS ADSORBING DEVICE, AND GAS SENSOR - A gas adsorbent includes a plurality of adsorbent particles. The plurality of adsorbent particles are aggregated together to form a porous structure. Each of the adsorbent particles includes: an insulating particle; and a plurality of conductive particles and an organic material, all of which adhere to a surface of the insulating particle. | 2022-06-16 |
20220187234 | MULTI-ENZYMATIC BIOSENSORS AND STABILIZATION OF MULTI-ENZYMATIC BIOSENSORS AT ROOM TEMPERATURE - Disclosed are multi-enzyme biosensors that are stable at ambient temperature, and methods of making thereof. | 2022-06-16 |
20220187235 | Ion-Selective Electrode and Electrolyte Concentration Determination Device - The present invention addresses the problem of improving both ion-selective electrode stability and adhesion between a sensitive film and a casing. This ion-selective electrode is characterized by being provided with: a sensitive membrane containing an ion-selective substance, a substrate, and a plasticizer; and a casing that holds the sensitive membrane, and by the casing material containing a substance having a solubility parameter (SP value) of 19.5 to 21.5. | 2022-06-16 |
20220187236 | ENHANCED CHLORIDE SELECTIVE MEMBRANE - There is provided a chloride selective membrane including an epoxide-based matrix reacted with a stoichiometric amount of an amino compound and an activator such that the epoxide-based matrix comprises a number of quaternary ammonium groups. | 2022-06-16 |
20220187237 | SENSOR ELEMENT, GAS SENSOR, AND METHOD FOR MANUFACTURING SENSOR ELEMENT - A sensor element including a first ceramic layer ( | 2022-06-16 |
20220187238 | ION SENSING DEVICE - An ion sensing device includes a first field-effect transistor, a second field-effect transistor, a reference electrode configured to directly contact a sample solution, a first ion-sensitive film, and a second ion-sensitive film. Each of the first field-effect transistor and the second field-effect transistor includes a semiconductor film, a bottom gate electrode, a bottom gate insulating film located between the bottom gate electrode and the semiconductor film, and a top gate insulating film. Surface materials in contact with the sample solution for the first ion-sensitive film and the second ion-sensitive films are the same. A sensitivity of the combination of the first field-effect transistor and the first ion-sensitive film is higher than a sensitivity of the combination of the second field-effect transistor and the second ion-sensitive film. | 2022-06-16 |
20220187239 | SENSOR WITH ROTATABLE SENSOR ELEMENT AND PRESSURE EQUALIZATION MECHANISM - A sensor may include a sensing element retained within a storage compartment filled with a storage medium, which may also be used as a calibration medium. The sensing element can include a sensing surface located away from the distal end of the sensing element, such that an inactive section of the sensing element can cooperate with a sealing member such as an O-ring to form part of the seal retaining the storage/calibration medium. The sensing element can be extended and retracted from the storage compartment to expose the sensing surface to a process medium, while preserving the storage medium within the storage compartment for post-measurement validation. | 2022-06-16 |
20220187240 | METHOD FOR TRAPPING MICROPARTICLE AND MICROPARTICLE TRAPPING DEVICE - A microparticle trapping device includes: a fluid channel configured to be injected with a fluid including a microparticle; first and second electrodes configured to generate an electric field in the fluid channel; and an electrical insulator formed with at least one opening between the first and second electrodes in the fluid channel. The electrical insulator is disposed between the first and second electrodes so that an inhomogeneous electric field is made through the at least one opening between the first and second electrodes in the fluid channel, and the still other aspect is configured to trap the microparticle through dielectrophoresis. | 2022-06-16 |
20220187241 | ELECTROPHORETIC ANALYSIS DATA PROCESSING DEVICE AND RECORD MEDIUM RECORDING ELECTROPHORETIC ANALYSIS DATA PROCESSING PROGRAM - In order to improve the operability of the device and reduce incorrect operations, a device for processing data acquired by an electrophoretic analysis according to the present invention includes: a display processor ( | 2022-06-16 |
20220187242 | IMPROVEMENTS IN OR RELATING TO A METHOD OF SEPARATING AND ANALYSING A COMPONENT - A method of separating and analysing a plurality of components in a heterogeneous sample is provided. The method comprising the steps of: introducing a separation fluid into a separation channel that is elongate in a first direction; introducing the heterogeneous sample into said channel; separating, in the first direction, the components in the sample; introducing an auxiliary fluid into said channel; creating a lateral distribution of the components in a second direction substantially perpendicular to the first direction; and determining, sequentially, a property of each of the components based on the regimen by which the lateral distribution was created. An apparatus for separating and analysing a plurality of components in a heterogeneous sample is also provided. | 2022-06-16 |
20220187243 | METHOD FOR DETECTING AN OKADAIC ACID BASED ON A NEAR-INFRARED PHOTOELECTRIC COMPOSITE MATERIAL - The present application proposes a method for detecting an okadaic acid based on a near-infrared photoelectric composite material, which includes the following steps: synthesizing NaYF | 2022-06-16 |
20220187244 | CURRENT MEASUREMENT METHOD - A current measurement method for measuring a tunneling current in biopolymers passing through between a pair of electrodes includes arranging the electrodes in a liquid that contains an electrolyte and, while applying a voltage between the electrodes, measuring a current flowing between the electrodes via an electric double layer formed along surfaces of the electrodes. This enables measuring the current in consideration of the electric double layer. As a result, it is possible to more accurately measure the tunneling current in the biopolymers included in a liquid sample that contains an electrolyte. | 2022-06-16 |
20220187245 | PHOTOIONIZATION DETECTOR AND METHOD OF OPERATING SAME - An electrode stack assembly includes an electrically insulative substrate having a cavity therethrough extending, a first counter electrode on a top surface thereof and extending through the substrate, a second sensing electrode on a bottom surface thereof and extending through the substrate, and a third electrode having a top body portion on a top of the substrate, a bottom body portion on a bottom of the substrate, and a coupling pin passing through the substrate and electrically coupling the top and bottom body portions. The third electrode electrically separates the pin of the sensing electrode from the counter electrode. | 2022-06-16 |
20220187246 | NONDESTRUCTIVE TESTING METHOD AND DEVICE FOR DETECTING AND DISTINGUISHING INTERNAL DEFECT AND EXTERNAL DEFECT OF WIRE ROPE - A nondestructive testing method for detecting and distinguishing internal and external defects of a wire rope includes: acquiring a magnetic flux signal and a MFL signal of a detected wire rope; preprocessing the magnetic flux signal and the MFL signal of the detected wire rope; comparing a preprocessed magnetic flux signal and a preprocessed MFL signal with a preset magnetic flux signal threshold and a preset MFL signal threshold respectively, and calculating a defect position; extracting a magnetic flux signal of a defect and an MFL signal of the defect based on the defect position; calculating a defect width of the detected wire rope based on the magnetic flux signal of the defect and the MFL signal of the defect; calculating a defect cross-sectional area loss of the detected wire rope based on the defect width; and determining whether the defect is the internal defect or the external defect. | 2022-06-16 |
20220187247 | MAGNETIC SENSOR AND INSPECTION DEVICE - According to one embodiment of the invention, a magnetic sensor includes a first sensor part. The first sensor part includes a first magnetic member, a first counter magnetic member, and a first magnetic element. A direction from the first magnetic member to the first counter magnetic member is along a first direction. The first magnetic element includes one or a plurality of first extending portions. A first portion of the first extending portion overlaps the first magnetic member in a second direction crossing the first direction. A first counter portion of the first extending portion overlaps the first counter magnetic member in the second direction. A first direction length along the first direction of the first extending portion is longer than a third direction length along a third direction of the first extending portion. The third direction crosses a plane including the first direction and the second direction. | 2022-06-16 |
20220187248 | SENSORS, METHODS, AND COMPUTER PROGRAM PRODUCTS FOR FLUID FLOW DETERMINATIONS - Sensors, methods, and computer program products for air bubble detection and fluid composition determinations are provided. An example sensor device for use with fluid flow systems includes a force pulse generator coupled with a fluid flow system that emits a force pulse and a force pulse sensor coupled with the fluid flow system. The force pulse sensor receives the force pulse emitted by the force pulse generator and determines the fluid flow system's transient response to the force pulse. Based upon the transient response, the force pulse sensor determines an operating condition of the fluid flow system. The operating condition may be indicative of the presence of an air bubble within the fluid flow system or may be indicative of a composition of a fluid within the fluid flow system. The force pulse sensor may further determine the amplitude and rate of decay of the transient response. | 2022-06-16 |
20220187249 | NON-DESTRUCTIVE TEST SYSTEMS WITH INFRARED THERMOGRAPHY ASSEMBLIES AND ULTRASONIC TEST ASSEMBLIES, AND ASSOCIATED METHODS - Non-destructive test systems and associated methods. A non-destructive test system includes an infrared thermography assembly and an ultrasonic test assembly for testing a test piece. The infrared thermography assembly may include one or more thermography sensor modules and a thermography test controller. The ultrasonic test assembly may include one or more ultrasonic sensor subassemblies with respective excitation modules and respective detector modules and an ultrasonic test controller. Each excitation module may be configured to produce a respective ultrasonic beam within the test piece, and each detector module may be configured to detect a respective reflected vibration of the test piece. In some examples, a method of performing a non-destructive test on a test piece includes testing an infrared test region of the test piece with an infrared thermography assembly and testing an ultrasonic test region of the test piece with an ultrasonic test assembly. | 2022-06-16 |
20220187250 | VEHICLE SYSTEM AND METHOD TO DETECT TIRE DAMAGE - A tire damage detection system for a vehicle includes: a tire; at least one sensor disposed in association with the tire to detect a noise signal when the tire rolls on a road surface to move the vehicle, the noise signal having a plurality of frequency peaks in a frequency spectrum of the noise signal; and a processor to monitor target frequency peaks of the frequency spectrum to detect damage of the tire, and to generate an alert signal in response to the detection of the damage of the tire. | 2022-06-16 |
20220187251 | FLUID MEASURING DEVICE - A fluid measuring device for determining at least one characteristic property of a fluid includes a measuring tube having a fluid duct and a measuring section in which the measuring tube is cylindrical on the inside and an area of a measuring tube wall is configured as a waveguide, and a transmitter for exciting acoustic waves in the waveguide and a receiver for receiving acoustic waves which are in direct contact with an outer surface of the waveguide, wherein acoustic waves excited by the transmitter are adapted to propagate as a volume wave through the fluid. The waveguide has an elongated waveguide path which extends at an acute angle to a longitudinal extension direction of the measuring tube and with a component in the circumferential direction, wherein in the area of the waveguide path, the measuring tube wall has a smaller wall thickness than in areas adjoining the waveguide path. | 2022-06-16 |
20220187252 | DIGITAL TWIN MODEL INVERSION FOR TESTING - Creation and use of a digital twin instance (DTI) for a physical instance of the part. The DTI may be created by a model inversion process such that model parameters are iterated until a convergence criterion related to a physical resonance inspection result and a digital resonance inspection result is satisfied. The DTI may then be used in relation to part evaluation including through simulated use of the part. The physical instance of the part may be evaluated by way of the DTI or the DTI may be used to generate maintenance schedules specific to the physical instance of the part. | 2022-06-16 |
20220187253 | STRUCTURE EVALUATION SYSTEM, STRUCTURE EVALUATION APPARATUS, AND STRUCTURE EVALUATION METHOD - According to one embodiment, a structure evaluation system according to an embodiment includes a plurality of sensors, a position locator, a corrector, and an evaluator. The plurality of sensors detect elastic waves generated from a structure. The position locator locates the position of a generation sources of a plurality of elastic waves on the basis of the plurality of elastic waves detected by the plurality of sensors. The corrector corrects information based on the position locating performed by the position locator using a correction value set in correspondence with an impact. The evaluator evaluates a deterioration state of the structure on the basis of the corrected information. | 2022-06-16 |
20220187254 | ION SUPPRESSOR - First and second electrode liquid seal members are arranged between a first electrode and a second electrode. First and second ion exchange membranes are arranged between the first electrode liquid seal member and the second electrode liquid seal member. An eluent seal member is arranged between the first ion exchange membrane and the second ion exchange membrane. A plurality of first mesh members having different charge amounts are stacked in a first electrode liquid flow path of the first electrode liquid seal member. Each of the plurality of first mesh members is constituted by a first wire group composed of a plurality of first wires and a second wire group composed of a plurality of second wires crossing the first wire group. The plurality of first wire groups of the plurality of first mesh members respectively extend in different directions, and the plurality of second wire groups of the plurality of first mesh members respectively extend in different directions and extend in directions different from those of the plurality of first wire groups. | 2022-06-16 |
20220187255 | LIQUID CHROMATOGRAPH - The state between a liquid sending pump and an analysis flow path is switched between a connection state and a disconnection state. In the connection state, a sample is injected into the analysis flow path, and a scheduled analysis is executed. When a variation range of a liquid sending pressure applied by the liquid sending pump exceeds a threshold value, a liquid sending failure is detected. In a case where a liquid sending failure is detected, the sample analysis in execution is interrupted, and the state between the liquid sending pump and the analysis flow path is put in the disconnection state. Further, a purge operation is executed. After the purge operation ends, a confirming operation of confirming whether a liquid sending failure is detected is executed. When a liquid sending failure is not detected, a non-injection analysis in which a mobile phase is sent into the analysis flow path by the liquid sending pump under a condition that enables removal of a sample in the analysis flow path is executed. A sample analysis is restarted after the non-execution analysis. | 2022-06-16 |
20220187256 | CATION CHROMATOGRAPHY USING PREDICTED ELUTION BUFFER SALT CONCENTRATION - The invention relates to a chromatography method of producing a target elution volume comprising a first and a second target protein. The method includes providing a cation exchange chromatography column; applying a protein solution on the column, the protein solution comprising the first target protein, a second target protein and optionally one or more further proteins; inputting an optimization criterion; computing chromatography simulations for computing an elution buffer salt concentration adapted to provide a target elution volume matching the optimization criterion best; computing the pooling borders of the target elution volume as a function of at least the computed salt concentration and the input optimization criterion; applying an elution buffer having the computed salt concentration on the chromatography column; performing the elution; and collecting the computed target elution volume. | 2022-06-16 |
20220187257 | DIFFERENTIAL REFRACTIVE INDEX MEASUREMENT METHOD, MEASUREMENT DEVICE, AND MEASUREMENT PROGRAM - A method of reducing noise in an output signal of a differential refractive index detection part (RI detection part) of a dual-flow type with an analysis device having the RI detection part includes sending a sample liquid to a sample cell with a sample pump, sending a reference liquid to a reference cell with a reference pump, and detecting a change in direction of travel of light sequentially transmitted through the two cells with a light detector. Before starting RI measurement, a phase difference between the sample pump and the reference pump is adjusted so that a noise that occurs in an output signal of the light detector by propagation of pulsation from the sample pump within the sample cell and a noise that occurs in the output signal of the light detector by propagation of pulsation from the reference pump within the reference cell cancel each other. | 2022-06-16 |
20220187258 | METHOD FOR MEASUREMENT OF HEMOGLOBIN - A reagent for use in the measurement of hemoglobins by liquid chromatography, the reagent comprising a nonionic surfactant selected from the group consisting of: | 2022-06-16 |
20220187259 | Peak Integration Correction without Parameter Adjustment - A separation device is instructed to separate a compound from a sample over a time period. A mass spectrometer is instructed to measure a plurality of intensities of at least one ion of the separated compound over the time period, producing a chromatogram. At least one peak of the at least one ion is identified from the chromatogram using a peak-finding algorithm. Two or more different peak integration areas are calculated for the at least one peak by applying the peak-finding algorithm with two or more different values for at least one peak-finding parameter. Two or more plots of the at least one peak that each shows graphically a different peak integration area are displayed on a display device at the same time. In response, data is received from a user selection device that indicates user selection of one of the two or more plots. | 2022-06-16 |
20220187260 | Agnostic Compound Elution Determination - Each of one or more unknown compounds are separated from a sample over a separation time period. Separated compounds are ionized, producing one or more compound precursor ions for each of the unknown compounds and a plurality of background precursor ions. A precursor ion mass spectrum is measured for the combined compound and background precursor ions at each time step of a plurality of time steps spread across the separation time period, producing a plurality of precursor ion mass spectra. One or more background precursor ions are selected from the plurality of precursor ion mass spectra that have a resolving power in a range below a threshold expected resolving power. A separation time is detected for an unknown compound when a decrease in an intensity measurement of the selected background precursor ions over a time period exceeds a threshold decrease in intensity with respect to time. | 2022-06-16 |
20220187261 | VOLATILE COMPONENT EVALUATION METHOD AND DEVICE USED THEREFOR - An apparatus includes a first flow channel connected to a gas release channel of a gas chromatograph that sends at least a volatile component separated by the gas chromatograph into the mouth of an evaluator; a container that stores a non-gaseous flowable specimen having fluidity; and a second flow channel that sends the flowable specimen into the mouth. | 2022-06-16 |
20220187262 | DEVICE AND METHOD FOR ANOMALY DETECTION OF GAS SENSOR - Disclosed are a device and a method for anomaly detection of a gas sensor. The device includes a measuring unit that extracts a characteristic of a gas supplied from the outside, generates data based on the extracted characteristic, and outputs the data, and a data processing unit that receives the data, determines whether an error occurs in the data, and outputs an anomaly detection result based on a result of determining whether the error occurs in the data. The measuring unit performs a calibration operation or an environment adjusting operation before extracting the characteristic, and the data processing unit determines whether the error occurs in the data, based on machine learning. | 2022-06-16 |
20220187263 | METHOD FOR DETERMINING A POTENTIAL POISONING OF A SENSOR OF AN ELECTRONIC NOSE BY A VOLATILE COMPOUND - A method determines a potential poisoning of a sensor of an electronic nose by a volatile compound following an exposure of the sensor to a gaseous sample including at least this volatile compound. If there is poisoning, the method determines whether the sensor is still functional such that the sensor is still capable of carrying out one or a plurality of reliable measurements, or on the contrary, whether the sensor is saturated and must no longer be used. The method may be used with any type of electronic nose. | 2022-06-16 |
20220187264 | DYNAMIC REVERSE GAS STACK MODEL FOR PORTABLE CHEMICAL DETECTION DEVICES TO LOCATE THREAT AND POINT-OF-SOURCE FROM EFFLUENT STREAMS - The present invention includes an apparatus and method for detecting the location of one or more sources of one or more target molecule, the apparatus comprising: a molecule detector; and a processor connected to the molecule detector and to a global position system, wherein the processor calculates the presence of the one or more target molecules, runs a computer code that determines a dynamic reverse gas stack model for the one or more target molecules, and triangulates the possible position for a source or effluent of the one or more target molecules based on the dynamic reverse gas stack model. The determined reverse gas stack model may have a Gaussian dispersion over one or more sampled locations. | 2022-06-16 |
20220187265 | INTERFERENT AND BASELINE DRIFT CORRECTING SENSOR SYSTEM - A sensor system that removes responses from an interferent and/or corrects for baseline drift of a sensor to determine a presence, a concentration or a change in concentration of a target material in a gaseous environment. Fluid flowing into the system may be directed by a valve arrangement to either a first fluid flow path or a second fluid flow path. The target material may be absorbed by a filter material in the first fluid flow path. Fluid flowing along the second gas flow path passes directly to the sensor. Responses of the sensor to fluids from the first and second fluid flow paths may be used to determine a presence, concentration or change in concentration of the target material. | 2022-06-16 |
20220187266 | SYSTEM AND METHOD FOR DETECTING GAS RECIRCULATION OR AIRWAY OCCLUSION - A display assembly system which detects abnormal operating conditions, such as gas recirculation or airway occlusion, is provided. An electronic display is located within a housing. Sensors measure characteristics of ambient air ingested by a thermal management subsystem. Weather conditions are gathered for a location, and measurements are received from the sensors regarding characteristics of the ingested ambient air. An alert is generated if the measurements change at a rate different from a rate of change of the weather conditions by at least a preterminal amount. | 2022-06-16 |
20220187267 | MARKER FOR SCREENING AND IDENTIFYING NOT-FROM-CONCENTRATE APPLE JUICE BASED ON NON-TARGETED METABOLOMICS AND USE THEREOF - The present disclosure discloses a marker for screening and distinguishing NFC apple juice based on non-targeted metabolomics and use thereof, relating to the technical field of distinguishing of juice. The marker for distinguishing NFC apple juice disclosed in the present disclosure is selected from the following molecules: gallocatechin, catechin, taxifolin, p-hydroxybenzaldehyde, 5-methoxysalicylic acid, azelaic acid, caffeic acid, chlorogenic acid, epicatechin, eriodictyol, ferulic acid, isoquercitrin, naringenin, n-fructosyl isoleucine, p-coumaraldehyde, p-coumaric acid, phloretin, phlorizin, procyanidin B1, quercetin-3-O-galactoside and rutin. The above markers may be used for distinguishing the NFC apple juice and the FC apple juice, and have relatively high accuracy. | 2022-06-16 |
20220187268 | DEVICE AND METHOD FOR CRUMBLING ROOT CROPS AND FOR DETERMINING COMPONENTS IN ROOT CROPS - The invention relates to a device for crumbling root crops into substantially equal sized pieces, comprising: a main frame having an inlet side and an outlet side; a root crop supply at the inlet side; at least one crumbling shaft rotatable supported in the main frame, the crumbling shaft being provided with a plurality of curved hooks, which are curved into a direction of rotation of the crumbling shaft; and a non-rotating cutting rake having a plurality of protrusions and recesses and forming a counter blade for the hooks, wherein the hooks are arranged for interlaced movement with said recesses of the non-rotating rake. The invention moreover concerns a system and a corresponding method. | 2022-06-16 |
20220187269 | SYSTEM AND METHOD FOR DETECTING ANALYTES IN WATER - An electrochemical sensor array for detecting analytes in water, including a frame; a plurality of sensor electrodes each mounted to the frame, including a free chlorine working electrode including a gold thin film and having a free chlorine sensing surface to be exposed to the water; and a reference electrode including a silver thin film and a silver and silver chloride layer and having a reference sensing surface to be exposed to the water. A method of manufacturing an electrochemical sensor array for detecting analytes in water, including forming a free chlorine electrode, including forming a gold thin film on a first base layer; forming a reference electrode, including forming a silver thin film on a second base layer and applying a silver and silver chloride paste to a portion of the silver thin film; and arranging the free chlorine electrode and the reference electrode on a common frame. | 2022-06-16 |
20220187270 | Method for Evaluating Carbon Source Quality of Water Body, Apparatus, Device and Readable Storage Medium - The invention relates to the technical field of environmental protection, in particular to a method for evaluating carbon source quality of a water body, an apparatus, a device and a readable storage medium. The invention provides a method for evaluating carbon source quality of a water body, including: acquiring COD and BOD | 2022-06-16 |
20220187271 | TRANSFER AND ONLINE DETECTION SYSTEM FOR DEEP-SEA SEDIMENT SAMPLES AND APPLICATION METHOD THEREOF - A transfer and online detection system for deep-sea sediment samples and an application method thereof are provided. A sample gripping and feeding device, a sample segment cutting device, a sample online detection device, a high-pressure ball valve and a pressure-retaining drill disengaging device of the system are coaxially connected with one another. A seawater booster pump is connected with a water inlet ball valve, and a valve control panel is connected with the sample gripping and feeding device, the sample segment cutting device, the high-pressure ball valve and the pressure-retaining drill disengaging device. The pressure-retaining drill disengaging device is configured for disengaging an inner barrel and an inner barrel joint, and the sample gripping and feeding device and the sample segment cutting device are configured for gripping and cutting core samples, and conveying the cut core samples into a subsample pressure-retaining storage cylinder for storage. | 2022-06-16 |
20220187272 | PROCESS AND SYSTEM FOR MEASURING THE OXIDATION STABILITY AND/OR THE THERMAL STABILITY OF A FUEL - The present invention relates to a system for characterizing at least one of the oxidation stability and the thermal stability of a fuel sample. The system comprises at least a device (MSIE) for performing an electrochemical impedance spectroscopy measurement in the sample, and a device (MDM) for determining deposit mass forming in the fuel sample. The invention further relates to a method for characterizing at least one of the oxidation stability and the thermal stability of the fuel over time, from measurements performed by the system according to the invention. | 2022-06-16 |
20220187273 | SELECTION METHOD OF BASE ASPHALT FOR RUBBER ASPHALT BASED ON GREY RELATIONAL ANALYSIS - The present disclosure provides a selection method of base asphalt for rubber asphalt based on grey relational analysis, which belongs to the technical field of selection methods of base asphalt. The selection method includes the following steps: determining factors affecting the performance of rubber asphalt and rubber asphalt performance evaluation indicators; ranking the factors affecting the performance of rubber asphalt according to respective affecting degrees thereof on each of the rubber asphalt performance evaluation indicators by using a grey relational method; and determining affecting factors of chemical components of base asphalt to the performance of rubber asphalt, and selecting base asphalt according to the affecting factors. The present disclosure uses the grey relational analysis method to systematically study the influences of chemical components of base asphalt on the performance of rubber asphalt. | 2022-06-16 |
20220187274 | NEMATODE TRAP PLATE AND USE THEREFOR - Provided is a test plate with which a test can be carried out in a simple manner and problems that may otherwise occur along with the lapse of time hardly occur. This invention provides a nematode trap plate ( | 2022-06-16 |
20220187275 | SYSTEMS AND METHODS FOR DIRECTED FORMATION OF SIZE-CONTROLLED MULTI-CELLULAR STRUCTURES AND MEASUREMENT OF FORCES GENERATED BY THE SAME - An assay for measuring cell-generated forces, is disclosed. The assay includes a first substrate comprising an elastic material having a Young's modulus of between about 0.1 kPa to about 50 kPa and a geometric micropattern disposed onto a surface of the substrate. The micropattern is further comprised of at least one segment consisting of a fluorophore-conjugated material, a material with cell adhesion properties, and has an interior region. | 2022-06-16 |
20220187276 | MICROFLUIDIC DEVICE FOR MEASURING CELL IMPEDANCE AND TRANSEPITHELIAL ELECTRICAL RESISTANCE - The present invention relates to a microfluidic device for determining the transepithelial electrical resistance (TEER) of a cell layer or a cell assembly and/or for determining the impedance of cells, a cell layer or a cell assembly, said device comprising at least one microchannel ( | 2022-06-16 |
20220187277 | DEVICE FOR MEASURING HEAVY METALS HAVING ELECTRODE ELEMENT - Provided herein is a device for measuring heavy metals having an electrode element and, most particularly, a device for measuring heavy metals having an electrode element including a device for measuring heavy metals having an electrode element including a substrate having a wireless communication electrode for wirelessly delivering an electrical variance that is measured from an electrode, when measuring heavy metals, an electrode element delivering an electrical signal for measuring heavy metals, and a controller controlling electric current application to the electrode element and detecting a quantity of electricity between electrodes being measured from a measurement object contaminated by heavy metal, or calculating a displacement between a reference quantity of electricity and a measured quantity of electricity. | 2022-06-16 |
20220187278 | METHOD AND DEVICE FOR DETECTING HOOK EFFECT IN TURBIDIMETRIC INHIBITION IMMUNOASSAY, AND COMPUTER READABLE MEDIUM - Provided are a method and device for recognizing hook effect in immune turbidimetry, and a computer readable medium. This method generates a reaction curve using light signals measured in a predetermined time period by immune reaction of analyte in a sample, and uses distribution information of the reaction curve in the predetermined time period to determine whether the sample has hook effect. This method only uses measurement information of a small predetermined time period in entire reaction time to determine whether a sample has hook effect, and terminates the test in time, thus accelerating the speed of immune turbidimetry detection of samples with hook effect. | 2022-06-16 |
20220187279 | RAPID T-CELL ASSAY FOR SARS-COV-2 - Methods for detecting the presence of sever acute respiratory coronavirus 2 (SARS-CoV-2) are provided. The methods comprise incubating a sample comprising T-cells from an individual with one or more SARS-CoV-2 antigens, each antigen having a T-cell epitope, and detecting a change in state of T-cells in the sample. The change in state may be detected by determining the presence or level of a secreted, immune response indicator, such as interferon-gamma (IFN-γ). | 2022-06-16 |
20220187280 | GENETICALLY ENCODED CELL DEATH INDICATORS AND METHODS OF USE - Genetically encoded death indicator (GEDI) polypeptides and nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides to monitor cell death events in vitro and in vivo, particularly in neuronal cell death, are also provided. | 2022-06-16 |
20220187281 | METHODS AND SYSTEMS FOR EVALUATION OF CELL SAMPLES - Described herein are methods and systems for evaluating cell samples, including tissue samples such as cancer tissue. In some cases, evaluating cell samples comprises longitudinal evaluation of one or more candidate molecules. Methods and systems for assessing cellular viability are provided. | 2022-06-16 |
20220187282 | CARDIOMYOCYTE PROLIFERATION - Provided herein are in vitro and in vivo methods of inducing cardiomyocyte proliferation by contacting cardiomyocytes with or administering to a subject an effective amount of an agent capable of activating sterol biosynthesis, such as mevalonate biosynthesis. Methods and compositions for regenerating a cardiac tissue in a subject that include administering thereto a therapeutically effective amount of an agent capable of activating sterol biosynthesis in a cardiomyocyte are also provided herein. | 2022-06-16 |
20220187283 | Method for the Diagnosis of Niemann-Pick Disease - The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising
| 2022-06-16 |
20220187284 | THREAD SPRAY AMBIENT IONIZATION - Disclosed herein are methods and apparatus useful for the collection, preservation, and analysis of biological fluids. In some embodiments, a hydrophobic thread is contacted with a biological sample. The hydrophobic thread stabilizes the biological sample over prolonged periods of time. Compounds, including small molecules and/or biopolymers, can be ionized by applying a suitable voltage to the tread. These ionized compounds can then be analyzed, for instance using mass spectrometry. | 2022-06-16 |
20220187285 | Automatic Analyzer - Provided is an automatic analyzer to control a temperature of a reagent supplied to a magnetic separator with high accuracy. The automatic analyzer includes a magnetic separator that separates a magnetic component and a non-magnetic component from liquid obtained by reacting a sample with a first reagent, a storage unit that accommodates a second reagent, a pipe used to supply the second reagent to the magnetic separator, and a heat exchanger that adjusts a temperature around the pipe. It is preferable that the heat exchanger includes a heat absorption and dissipation unit and a fan that blows air heat-exchanged by the heat absorption and dissipation unit, and the air blown from the fan is blown onto the pipe. | 2022-06-16 |
20220187286 | SINGLE CELL SECRETOME ANALYSIS - Systems, methods, compositions, and kits for measuring secreted factors from cells are disclosed herein, including those capable of determining single cell secretion activity and protein expression and/or gene expression simultaneously. Disclosed herein include solid supports comprising a plurality of capture probes capable of specifically binding to at least one of the plurality of secreted factors secreted by a single cell. Also disclosed herein include secreted factor-binding reagents capable of specifically binding to a secreted factor bound by a capture probe. A secreted factor-binding reagent can comprise a secreted factor-binding reagent specific oligonucleotide comprising a unique factor identifier sequence for the secreted factor-binding reagent. | 2022-06-16 |
20220187287 | MAGNETIC RESPONSIVE PARTICLE AND IMMUNOASSAY METHOD USING SAME, REAGENT FOR IMMUNOASSAY - Disclosed is a sensitized magnetic responsive particle including: a magnetic responsive particle having a core particle and at least one magnetic layer that is disposed on the core particle and includes microparticles of a magnetic metal and/or an oxide thereof; and a substance that is supported on the magnetic responsive Particle and interacts specifically with an analyte, wherein the coefficient of variation in the weight-average particle size of the magnetic responsive particles is 15% or less. The magnetic responsive particle provided has excellent magnetic separability. | 2022-06-16 |
20220187288 | AUTOMATED PATHOGEN AND ANTIBODY RAPID TEST - Embodiments may include a rapid test device that provide rapid detection of pathogen infection and techniques for rapid assessment of immunity to the pathogen. In an embodiment, a device may comprise a mechanism configured to hold a cartridge configured to receive a test sample, the cartridge comprising: a first chamber configured to receive the test sample, the first chamber pre-filled with micromagnetic particles, a first reservoir pre-filled with secondary antibodies labeled with a fluorescent compound, a mechanism configured to move the secondary antibodies from the first reservoir to the first chamber, a computer system to control the mechanism configured to move the magnetic device to: mix the micromagnetic particles with the test sample by moving the micromagnetic particles, mix the micromagnetic particles with the secondary antibodies, and move the micromagnetic particles to the detection region, and circuitry configured to detect fluorescence of the fluorescent compound in the detection region. | 2022-06-16 |
20220187289 | METHODS FOR DETECTING, ISOLATION, AND QUANTIFYING AN ANALYTE IN A SAMPLE BASED ON COLLOIDAL SUSPENSION OF PLASMONIC METAL NANOPARTICLES - There are provided methods for quantifying an analyte in a sample, diagnosing a condition characterized by an excess or a depletion of an analyte in a biological sample, isolating analyte from a sample, and detecting an analyte in a sample. These method comprise the steps of providing a colloidal suspension of nanoparticles of a plasmonic metal, the nanoparticles having attached on their surface a binding moiety for selective attachment of said analyte and adding the sample to the suspension, thus producing a mixture in which said analyte is attached to the nanoparticles in suspension. Then, the methods further comprise the steps of either
| 2022-06-16 |
20220187290 | IMMUNOCHROMATOGRAPHIC ASSAY METHOD, AND TEST STRIP USED IN SAID IMMUNOCHROMATOGRAPHIC ASSAY METHOD - The invention aims to suppress non-specific reaction effectively in an immunochromatographic assay method for an analyte. The object can be achieved by an immunochromatographic assay method for an analyte, the method including using a test strip including the following (1) to (3): (1) a sample pad containing a sample application region for applying a biological sample that may contain the analyte; (2) an insoluble membrane containing at least one detection region to which a binding partner immunologically reactive with the analyte is immobilized, wherein the binding partner is immobilized to a label; and (3) a conjugate containing a binding partner immunologically reactive with the analyte, wherein the binding partner is immobilized to a label. | 2022-06-16 |
20220187291 | DEVICES AND METHODS FOR TEMPERATURE CORRECTION FOR LATERAL FLOW TESTING - Temperature effects on results of a lateral flow assay can be compensated for by measuring an environmental temperature at a testing time and a testing location, performing a lateral flow assay at the testing time and testing location to obtain an original concentration value of a target substance, and generating a modified concentration value of the target substance. The modified concentration value is generated based on the original concentration value, by compensating for a difference between the environmental temperature and ambient temperature. | 2022-06-16 |
20220187292 | METHOD AND DEVICE FOR MEASURING THE FIBRINOGEN CONCENTRATION IN BLOOD SAMPLES - A diagnostic device which enables measurement of fibrinogen concentration in a blood sample. The device comprises; a wettable testing substrate including viewing indicators which allow determination of a status of a test. The substrate has a first end and second end and intermediate therebetween a flow receiving zone, a flow path zone and a reaction zone; the reaction zone pre charged with at least one reagent. A blood sample to be tested is deposited near or in either of said flow receiving zone or said reaction zone, the sample reacting with the reagents inducing clotting of the sample. Water added to a dye added to said reaction zone, advances a distance along said substrate. The distance travelled along the substrate by the dye and through the sample is indicative of a measure of concentration of fibrinogen in said blood sample under test. | 2022-06-16 |
20220187293 | SYSTEMS AND METHODS FOR RHEUMATOID ARTHRITIS BIOMARKER DETECTION - Embodiments provide for devices and methods of use for detecting one or more biomarkers of rheumatic disease in a subject. In an example, a method includes detecting citrullinated human serum albumin (HSA) in a biological sample via obtaining the biological sample from a subject, applying the biological sample to a lateral flow device under conditions sufficient for formation of an immunocomplex comprising anti-HSA antibody coupled to citrullinated HSA that is in turn coupled to anti-citrullinated HSA autoantibody, determining a quantity of the immunocomplex, and managing rheumatic disease associated with the subject. In this way, rheumatic disease may be effectively managed based at least in part on amounts of citrullinated HSA detected via rapid point-of-care test methodology. | 2022-06-16 |
20220187294 | MATERIALS AND METHODS FOR DETECTING AND TREATING AUTOIMMUNE MOVEMENT DISORDERS - Materials and methods are provided herein for detecting the presence of an autoantibody specific for PDE10A to identify the mammal as having an autoimmune neurological disorder as well as methods and materials for treating an autoimmune neurological disorder. Materials and methods also are provided herein for treating cancer and/or neurological autoimmunity in a mammal using an immune checkpoint inhibitor and detecting the presence of an autoantibody specific for PDE10A to monitor for the development of neurologic complications in the mammal. | 2022-06-16 |
20220187295 | Biomarkers for Predicting Multiple Sclerosis Disease Activity - Disclosed herein are methods for analzying quantitative expression values of biomarkers of a biomarker panel for determining disease activity in a human subject. Further disclosed herein are kits for measuring quantitative expression values of the markers as well as computer systems and software embodiments of predictive models for determining disease activity in human subjects based on the quantitative expression values of the markers. | 2022-06-16 |
20220187296 | METHOD OF EVALUATING PROGRESSION OF AN INFECTIOUS DISEASE AND/OR INFLAMMATORY DISEASE - There is provided a method of evaluating risk of severe outcome of an infectious disease and/or an inflammatory disease in a patient, the method comprising: determining/measuring the number of one or more immune cells selected from the group consisting of VD2 T cells, CD8 T cells, and immature neutrophils in a sample obtained from the patient, wherein the patient has an enhanced risk of severe infectious disease and/or inflammatory disease outcome when: (i) the ratio of immature neutrophils to VD2 T cell is at least 2:1, and/or (ii) the ratio of immature neutrophils to CD8 T cell is at least 0.5:1. Also disclosed are method of treating a patient with a severe infectious disease and/or inflammatory disease and kit for use in methods thereof. | 2022-06-16 |
20220187297 | HUMAN METAPNEUMOVIRUS DETECTION REAGENT - An object of the invention is to provide a detection reagent which can detect human metapneumovirus in an actual analyte with an excellent sensitivity. The invention relates to a human metapneumovirus detection reagent characterized by containing an antibody which recognizes the matrix protein of human metapneumovirus, an immunological assay for human metapneumovirus including detecting human metapneumovirus in an analyte with an antibody which recognizes the matrix protein of human metapneumovirus and the like. | 2022-06-16 |
20220187298 | A METHOD OF IDENTIFYING A FLAVIVIRUS INFECTION, AND RELATED PEPTIDES, KITS AND COMPOSITIONS - There is provided a method of identifying a flavivirus infection selected from Zika virus (ZIKV), Dengue virus (DENV) and combination thereof in a subject, the method comprising determining whether a sample of the subject reacts with a peptide associated with a certain relative binding capacity. Also claimed are kits, isolated peptides, immune system stimulating compositions comprising specific peptides and a method of distinguishing ZIKV infection from DENV infection. | 2022-06-16 |
20220187299 | METHODS OF DETERMINING PATIENT POPULATIONS AMENABLE TO IMMUNOMODULATORY TREATMENT OF CANCER - The disclosure provides methods of determining patient populations amenable or suitable for immunomodulatory treatment of disease such as cancer by measuring the relative or absolute levels of T-cell sub-populations correlated with disease such as cancer. | 2022-06-16 |
20220187300 | TUMOR CELL-DERIVED MICROVESICLES - The present invention relates to a method for diagnosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anticancer treatment in a sample of a subject by detecting oncogenic and cancer related proteins in microvesicles, and to the use of an agent blocking exchange of microvesicles for treating cancer. | 2022-06-16 |
20220187301 | METHOD OF SELECTION FOR TREATMENT OF SUBJECTS AT RISK OF INVASIVE BREAST CANCER - The present disclosure provides compositions and methods for the treatment of subjects having a risk of invasive breast cancer. In some embodiments, these aspects allow for the pairing of the proper treatment option for the particular subject. In some embodiments, this allows for identifying subjects who, while at risk for invasive breast cancer, will not normally respond to radiation therapy, and can instead receive an alternative therapy, such as a HER2 antibody. | 2022-06-16 |
20220187302 | DETECTION DEVICE AND DETECTION METHOD OF DOT IMMUNOBLOTTING DETECTION - The present invention provides a detection device of dot immunoblotting detection, including a negative pressure suction device, a hole plate, a hose for connecting the hole plate with the negative pressure suction device, and a nitrocellulose membrane in tight fit with the upper end surface of the hole plate. The present invention further provides a detection method of dot immunoblotting detection, including preparation, sample injection, blocking, incubation of a primary antibody, incubation of a secondary antibody, development and analysis. The detection method performs negative pressure suction through the negative pressure suction device, which is favorable for concentrating samples during sample injection and avoiding the influence, caused by cross contamination after diffusion of the samples, on an experimental result, and the experimental result is more accurate. | 2022-06-16 |
20220187303 | METHOD AND COMPOSITION FOR DETECTION OF PROTEOLYTIC PRODUCTS AND DIAGNOSIS OF MALIGNANT NEOPLASTIC DISEASE - Tumor invasion and metastasis is accompanied by significant activations of specific proteolysis enzymes. Tumor area is known to have increased infiltration of immunoglobulins G (“IgG”), so IgG may undergo proteolysis in this area. Serine proteases usually cleave peptide bonds between positively charged amino acids lysine and arginine. Since the intact PLG molecules as well as its fragments have lysine binding sites, they can bind to damaged IgG or fragments thereof with free C-terminal lysine that can appear in a circulation after proteolysis in the malignant tumor area. In the present invention we demonstrated the increased binding of damaged IgG or fragments thereof with free C-terminal lysine to fragments of PLG in samples from patients with breast cancer, ovarian cancer, lung cancer, colorectal cancer, prostate cancer vs. samples from healthy donors, and thus we proposed a novel diagnostic method. | 2022-06-16 |
20220187304 | A Method for Measuring a Concentration of a Biomarker-Analyte In Blood from Mammals - The present invention relates to a method for measuring a concentration of one or more biomarker in blood from a mammal comprising: —providing a kit of parts for sampling blood comprising a lancet and a capillary, a vial comprising an extraction fluid and one or more internal standard, which is a radioisotope of one or more biomarker adapted to assess a quality and a concentration of the one or more biomarker in the blood sample, —distributing the kit of parts to the mammal, —receiving the vial comprising a blood sample inserted into the vial, —analysing the sample to determine the quality of the sample and the concentration of the one or more biomarker in the blood of the mammal by centrifuging the vial and performing a direct analysis of the supernatant. | 2022-06-16 |
20220187305 | METHOD FOR SCREENING PERSONALIZED INTESTINAL ENVIRONMENT-IMPROVING MATERIAL AND COMPOSITION THEREFOR - The present disclosure relates to a composition for screening an intestinal environment-improving material and a screening method using the composition, and according to the composition and the method of the present disclosure, it is possible to provide an effective analysis method for screening a microbiota-improving candidate material in a personalized manner by providing a method for verifying personalized probiotics, prebiotics, foods, health functional foods and drugs under in vitro conditions based on microbiota and microbiota metabolites. | 2022-06-16 |
20220187306 | CONCURRENT ANALYSIS OF MULTIPLE ANALYTES - Methods, apparatuses and systems are described that are capable of simultaneously determining the presence, identities or levels of multiple analytes present in a single sample, by carrying out steps including denaturation, normalization, extraction, mixed-mode liquid chromatography and mass spectrometry, whereby the presence, identities or levels of analytes in the single sample are determined. | 2022-06-16 |
20220187307 | Biomarkers for improving nutrion for infants at risk - The invention relates to biomarkers in the umbilical cord epithelium relating to skin proteins that are better predictive for the development of atopic dermatitis late in life. These biomarkers enable an early nutritional intervention in a more precisely determined population of at risk infants. | 2022-06-16 |