24th week of 2022 patent applcation highlights part 30 |
Patent application number | Title | Published |
20220186106 | Injection Fluids Comprising Alkoxylated Alcohols and the Use of Such Fluids in Oil Recovery Processes - The present invention is concerned with an injection fluid comprising liquid or super-critical carbon dioxide (CO | 2022-06-16 |
20220186107 | THICKENER FOR WELLBORE ACID TREATMENT LIQUID AND WELLBORE ACID TREATMENT LIQUID USING SAME - An object of an embodiment of the present invention is to provide a thickener for a wellbore acid treatment liquid which thickener has excellent hydrolysis resistance and a high thickening capability. A thickener (X) for a wellbore acid treatment liquid contains a surfactant (a) as expressed by General Formula 1 below. | 2022-06-16 |
20220186108 | COLOUR CONVERSION FILM, AND BACK LIGHT UNIT AND DISPLAY DEVICE COMPRISING SAME - The present specification relates to a color conversion film comprising a color conversion functional layer including a phase change material, and a backlight unit and a display apparatus including the color conversion film. | 2022-06-16 |
20220186109 | OPTICAL FILM, BACKLIGHT MODULE AND MANUFACTURING METHOD OF OPTICAL FILM - An optical film, a backlight module and a manufacturing method of the optical film are provided. The optical film includes a quantum dot gel layer and a shielding layer disposed on the quantum dot gel layer. The quantum dot gel layer includes a first polymer and a plurality of quantum dots dispersed in the first polymer. The first polymer includes 1 to 5 wt % of photoinitiator, 3 to 20 wt % of scattering particles, 5 to 40 wt % of thiol compound, 5 to 30 wt % of monofunctional acrylic monomer, 10 to 30 wt % of multifunctional acrylic monomer, 15 to 30 wt % of oligomer, and 100 to 1200 ppm of inhibitor. | 2022-06-16 |
20220186110 | OPTICAL FILM, BACKLIGHT MODULE AND MANUFACTURING METHOD OF OPTICAL FILM - An optical film, a backlight module and a manufacturing method of the optical film are provided. The optical film is composed of a quantum dot gel layer. The quantum dot gel layer includes a first polymer and a plurality of quantum dots dispersed in the first polymer. The first polymer includes 1 to 5 wt % of photoinitiator, 3 to 20 wt % of scattering particles, 20 to 40 wt % of thiol compound, 5 to 30 wt % of monofunctional acrylic monomer, 20 to 40 wt % of multifunctional acrylic monomer, 1 to 5 wt % of organosilicon grafted oligomer, and 500 to 1500 ppm of inhibitor. | 2022-06-16 |
20220186111 | HIGHLY TUNABLE FLUORESCENT CORE-SHELL PARTICLES FOR ENVIRONMENTAL RELEASE SIMULATION AND TRACKING APPLICATIONS - A particle for emulating pollutant tracking in water has a florescent core. A semitransparent shell is formed around the florescent core. | 2022-06-16 |
20220186112 | HIGH QUANTUM DOT DISPERSION COMPOSITION, OPTICAL FILM, AND BACKLIGHT MODULE - A high quantum dot dispersion composition, an optical film, and a backlight module are provided. The high quantum dot dispersion composition includes 1 to 5 wt % of photoinitiator, 3 to 20 wt % of scattering particles, 15 to 50 wt % of thiol compound, 5 to 30 wt % of monofunctional acrylic monomer, 20 to 40 wt % of multifunctional acrylic monomer, 1 to 5 wt % of organosilicon grafted oligomer and 500 to 1500 ppm of inhibitor. | 2022-06-16 |
20220186113 | COMPOSITION - The invention relates to a composition and method of manufacturing such composition, the composition. | 2022-06-16 |
20220186114 | ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME - The present disclosure relates to organic electroluminescent compounds and an organic electroluminescent device comprising the same. The organic electroluminescent compound according to the present disclosure may be comprised in a light-emitting layer or an electron buffer layer, and is effective to produce an organic electroluminescent device having low driving voltage, excellent current and power efficiencies, and significantly improved operative lifespan. | 2022-06-16 |
20220186115 | RED PHOSPHOR AND METHOD FOR PRODUCING SAME - A red phosphor that has optical characteristics and durability under high-temperature and high-humidity environments, and a method for producing the same. The red phosphor includes a Mn-activated complex fluoride represented by the following general formula (1) and bismuth: | 2022-06-16 |
20220186116 | BLUE-EMITTING PHOSPHORS AND METHODS OF USE THEREOF - Provided herein are phosphors of the general molecular formula: | 2022-06-16 |
20220186117 | CERAMIC COMPLEX, LIGHT EMITTING DEVICE, AND METHOD FOR PRODUCING CERAMIC COMPLEX - A ceramic complex including a first crystal phase containing a first rare earth aluminate fluorescent material containing an activating element and a first rare earth element that is different from the activating element, and a second crystal phase containing aluminum oxide, having a content of the first crystal phase in a range of 5% by volume or more and 40% by volume or less and a content of the second crystal phase in a range of 57% by volume or more and 95% by volume or less based on a total amount of the ceramic complex, having an average value of a second crystal diameter of the second crystal phase measured under the particular measurement condition of 12 μm or less, and having a QD value of 0.5 or less expressed by QD=(D | 2022-06-16 |
20220186118 | METHODS AND SYSTEM FOR A MIXED LIQUID OXIDANT - Herein disclosed are compositions of mixed liquid oxidants and methods for their use in remediating soil and groundwater. The composition includes a mixture of permanganate and persulfate in liquid form. The method includes determining contaminants in soil and groundwater and applying the mixed liquid oxide to oxidize the contaminants. | 2022-06-16 |
20220186119 | LIQUID CRYSTAL COMPOSITION, DICHROIC MATERIAL, LIGHT ABSORPTION ANISOTROPIC FILM, LAMINATE, AND IMAGE DISPLAY DEVICE - Provided is a liquid crystal composition capable of forming a light absorption anisotropic film with excellent light resistance, a dichroic material, a light absorption anisotropic film, a laminate, and an image display device. The liquid crystal composition contains a liquid crystal compound and a dichroic material having a structure represented by Formula (1). | 2022-06-16 |
20220186120 | COMPOSITE CONDENSED MATTER MATERIAL AND METHODS OF USING AND FORMING SAME - Composite condensed matter material, devices including the composite condensed matter material, and methods of forming and using the composite condensed matter material are disclosed. The composite condensed matter material includes a host material and particles dispersed and suspended within the host material. The composite condensed matter material can exhibit one or more low symmetry phases and reconfigurable properties. | 2022-06-16 |
20220186121 | SYSTEMS AND METHODS FOR RECYCLING WASTE PLASTICS - Systems and methods for processing waste plastics are provided. One method includes mixing, heating and compacting a supply of the waste plastic based feedstock having an appreciable amount of halide compounds or heteroatoms from one or more sources of contamination; providing an amendment comprising alkaline earth oxides and/or hydroxides, oxides of iron, and/or oxides of aluminum to be mixed, heated and compacted with the waste plastic based feedstock to form a densified melt of plastic material including the amendment; and pyrolyzing the densified melt of plastic material including the amendment within a pyrolysis reactor. Another method includes pyrolyzing a supply of the waste plastic feedstock within a pyrolysis reactor to generate a hydrocarbon gas stream and a solids residue stream; condensing out a tars product from the hydrocarbon gas stream output from the pyrolysis reactor with a quenching apparatus; and pyrolyzing the tars product within a supplemental pyrolysis reactor. | 2022-06-16 |
20220186122 | PROCESS FOR EXTRACTING CRUDE OIL FROM DIATOMACEOUS EARTH - A process for extracting crude oil from a solid, oil bearing diatomaceous earth. In the process includes the step (a) of mixing crude oil-bearing diatomaceous earthwith a heated solvent such as toluene to reduce the size of the oil-bearing diatomaceous earthand release crude oil into the solvent, step (b) of adding water to the size reduced solid and solvent mixture of step (a) to yield a mixture of crude oil+solvent+water+sized reduced diatomaceous earth, step (c) of passing the mixture of crude oil+solvent+water+sized reduced diatomaceous earthfrom step (b) through a cyclone separator to remove residual solids and to yield crude oil+solvent; and step (d) of passing the crude oil+solvent mixture of step (c) through a solvent stripper to remove solvent from the crude oil and to yield substantially diatomaceous earthand solvent free crude oil. | 2022-06-16 |
20220186123 | Fischer-Tropsch Process, Supported Fischer-Tropsch Synthesis Catalyst and Uses Thereof - A process for converting a mixture of hydrogen and carbon monoxide gases to a composition comprising alcohols and liquid hydrocarbons by means of a Fischer-Tropsch synthesis reaction, said process comprising contacting a mixture of hydrogen and carbon monoxide gases, preferably in the form of synthesis gas mixture, with a supported Co—Mn Fischer-Tropsch synthesis catalyst, wherein: the support material of the supported Co—Mn Fischer-Tropsch synthesis catalyst comprises a material selected from titania, zinc oxide, zirconia, and ceria; the supported synthesis catalyst comprises at least 2.5 wt % of manganese, on an elemental basis, based on the total weight of the supported synthesis catalyst; the weight ratio of manganese to cobalt, on an elemental basis, is 0.2 or greater; the molar ratio of hydrogen to carbon monoxide is at least 1; and, the Fischer-Tropsch synthesis reaction is conducted at a pressure in the range of from 1.0 to 10.0 MPa absolute. | 2022-06-16 |
20220186124 | CO-CRACKING PYOIL WITH ETHANE - A hydrocarbon cracker stream is combined with recycle content pyrolysis oil to form a combined cracker stream and the combined cracker stream is cracked in a cracker furnace to provide an olefin-containing effluent. The r-pyoil can be fed to the cracker feed. More specifically cracking the cracker feedstock in said cracker furnace to provide an olefin-containing effluent stream; wherein the hydrocarbon composition is predominantly ethane. | 2022-06-16 |
20220186125 | METHODS OF HYDROCARBON PRODUCTION ENHANCED BY IN-SITU SOLVENT DE-ASPHALTING - Disclosed herein are methods for producing hydrocarbons from a subterranean reservoir that is penetrated by an injection well and a production well. The methods comprise operating the injection well under a set of injection parameters and operating the production well under a set of production parameters to produce a production fluid that has an API gravity that changes over time (ΔAPI) as the method is advanced towards an ultimate recovery factor (RF | 2022-06-16 |
20220186126 | SOLVENT DEASPHALTING DEAROMATIZATION PROCESS FOR HEAVY OIL UPGRADATION - An aspect of the present disclosure relates to a process for solvent deasphalting dearomatization, said process including: effecting deasphaltenation of a heavy oil feed by contacting the feed with a paraffinic rich solvent, optionally, in presence of a FCC catalyst to obtain a deasphalted oil rich stream, said paraffinic rich solvent being untreated naphtha; contacting the DAO rich stream with a second solvent to obtain a raffinate stream rich in non-asphaltene and non-aromatic contents and a solvent rich stream; contacting the raffinate stream with water in a first decanter to obtain a first stream rich in aromatic-lean fraction and a second stream rich in the second solvent and water; subjecting the first stream to distillation to recover the paraffinic rich solvent and to obtain deasphalted oil; contacting the solvent rich stream with water in a second decanter to obtain an aromatic rich fraction and a third stream rich in the second solvent and water; and subjecting the second stream and the third stream to distillation to recover the second solvent and water. | 2022-06-16 |
20220186127 | PROCESS OF REFORMING DIESEL FEEDSTOCK - A process of reforming a diesel feedstock to convert diesel to a gasoline blending component may include desulfurizing and denitrogenizing the diesel feedstock to reduce the sulfur and nitrogen content; and then hydrocracking the diesel feedstock over a metal containing zeolitic catalyst to produce an isomerate fraction. The diesel feedstock may have boiling points ranging from 200 to 360° C. | 2022-06-16 |
20220186128 | STEAM CO-INJECTION FOR THE REDUCTION OF HEAT EXCHANGE AND FURNACE FOULING - A process for removing or reducing the accumulation of foulant within furnaces and heat exchangers in industrial systems such as an oil refinery by introducing a periodic steam blast. The steam blast is directed into the fluid stream from which the foulants form on to the heat exchanger surfaces. The steam blast increases the flow rates, creates turbulence and increases the temperature within the heat exchanger to dislodge foulant in both a soft and hardened states from internal surfaces upon which foulants have adhered and accumulated. | 2022-06-16 |
20220186129 | METHOD TO MITIGATE FOULING IN A HYDROCARBON PLANT - Described herein are systems and methods of fouling mitigation in a hydrocarbon fractionation column. The methods correlate operating parameters of the fractionation column, specifically flow rate and temperature, with fouling. The methods can include measuring a temperature and a flow rate at a bottom stream of the hydrocarbon fractionation column; providing the measured temperature and flow rate to a processing device; determining, by the processing device, based on the measured temperature and flow rate of the bottom stream, an antifoulant treatment protocol for the hydrocarbon fractionation column; and treating the hydrocarbon fractionation column by controlling, by the processing device, a feed control unit in accordance with the determined antifoulant treatment protocol. | 2022-06-16 |
20220186130 | COOLING JACKET FOR GASIFICATION BURNER - A feed injector for a gasifier comprising a burner and a cooling jacket to protect the burner from high temperatures. The cooling jacket comprises two concentric channels in order to provide a flow path for a heat transfer fluid, typically water, to travel through one channel toward the burner front, travel along the burner front, and return through the other channel. Heat transfer in the cooling jacket is improved by introducing one or more fins in the path of the heat transfer fluid and/or by increasing the radius of curvature of the wall corner bordering the flow recirculation zone in the cooling jacket. | 2022-06-16 |
20220186131 | FUEL INCLUDING POLY-OXYGENATED METAL HYDROXIDE - A composition including poly-oxygenated metal hydroxide material that comprises a clathrate containing oxygen gas (O | 2022-06-16 |
20220186132 | GREASE COMPOSITION AND METHOD FOR PRODUCING THE SAME - A grease composition including 10 to 98% by mass of a lubricant base oil (A) having a kinematic viscosity at 100° C. of 1 to 14 mm | 2022-06-16 |
20220186133 | LUBRICATING OIL COMPOSITION FOR INDUSTRIAL GEARS AND METHOD FOR PRODUCING THE SAME - A lubricating oil composition for industrial gears, including 10 to 90% by mass of a lubricant base oil (A) having a kinematic viscosity at 100° C. of 1 to 100 mm | 2022-06-16 |
20220186134 | LUBRICATING OIL COMPOSITION FOR INTERNAL COMBUSTION ENGINES AND METHOD FOR PRODUCING THE SAME - A lubricating oil composition for internal combustion engines, including a lubricant base oil and a liquid random copolymer of ethylene and an α-olefin, the liquid random copolymer being produced using a specific catalyst, wherein the lubricating oil composition has a kinematic viscosity at 100° C. of 12.5 mm | 2022-06-16 |
20220186135 | LUBRICATING GREASE COMPRISING METAL SOAPS AND METAL COMPLEX SOAPS BASED ON R-10-HYDROXYOCTADECANOIC ACID - The invention relates to lubricating greases based on alkali metal soaps and/or earth-alkali metal soaps and metal complex soaps based on (R)-10-hydroxyoctadecanoic acid and to the use thereof. | 2022-06-16 |
20220186136 | LUBRICATING OIL COMPOSITION AND METHOD FOR PRODUCING LUBRICATING OIL COMPOSITION - A method for producing a lubricating oil composition of the present embodiment includes an irradiation step of irradiating a fullerene solution in which fullerenes are dissolved in a base oil with radiation, in which the above-described radiation is ultraviolet light or ionizing radiation. | 2022-06-16 |
20220186137 | LUBRICATING OIL COMPOSITION - The invention addresses a problem of providing a lubricating oil composition for gas engines capable of suppressing viscosity increase while reducing a sulfated ash content and excellent in high-temperature detergency and base number retention. The lubricating oil composition is used for gas engines and contains a base oil (A), at least one ash-free additive (B) selected from an ash-free sulfur-based antioxidant (B1) and a hindered amine compound (B2), and a boronated imide-type dispersant (C), and satisfies the following requirements (X1) to (X3): Requirement (X1): the sulfated ash content is 0.2% by mass or less. Requirement (X2): the content of the ash-free additive (B) is 1.2% by mass or less based on the total amount of the lubricating oil composition, provided that in the case where the ash-free additive (B) contains the hindered amine compound (B2), the content of the hindered amine compound (B2) is less than 1.0% by mass based on the total amount of the lubricating oil composition. Requirement (X3): the content of the boron atom derived from the boronated imide-type dispersant (C) is 200 ppm by mass or more based on the total amount of the lubricating oil composition. | 2022-06-16 |
20220186138 | LUBRICATING OIL COMPOSITION FOR REFRIGERATOR - The invention addresses a problem of providing a lubricating oil composition for refrigerators excellent in thermal stability for a refrigerant that contains difluoromethane (R32), trifluoroiodomethane (CF | 2022-06-16 |
20220186139 | OIL PROCESSING - A process for manufacturing a refined vegetable oil having a reduced content of 3-MCPD esters characterized in that it comprises the following steps: treating a deodorized vegetable oil with a base in a continuous pipe reactor, and contacting the base treated oil with an adsorbent and/or an acid. The thus obtained oil is low in 3-MCPD and has a low degree of interesterification and a low DAK content. It further relates to the use a continuous pipe reactor for treating a deodorized vegetable oil with a base wherein 3-MCPD ester content is reduced in the oil. | 2022-06-16 |
20220186140 | IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS - A compound according to formula I in the form of any one of its stereoisomers or a mixture thereof | 2022-06-16 |
20220186141 | FLUORINATED SURFACTANT COMPOSITION - Disclosed is a surfactant composition in which at least one of surface tension and interfacial tension is superior, the composition including a fluorinated surfactant and a phospholipid-based surfactant, and optionally further including a sulfosuccinate-based surfactant. | 2022-06-16 |
20220186142 | AUTOMATIC DISHWASHING COMPOSITION - An automatic dishwashing composition having a ternary mixture of non-ionic surfactants comprising: i) a non-ionic surfactant having a high cloud point of 50° C. or above; ii) a non-ionic surfactant having a low cloud point below 50° C.; and iii) an ethylene oxide- propylene oxide block copolymer having a cloud point below 50° C. | 2022-06-16 |
20220186143 | DETERGENT COMPOSITION HAVING REDUCED TURBIDITY - A detergent composition includes:
| 2022-06-16 |
20220186144 | Unit Dose Laundry Detergent Compositions Containing Soil Release Polymers - A unit dose detergent product includes a unit dose pouch with a water soluble film, and a liquid detergent encapsulated in the unit dose pouch. The liquid detergent includes a soil release polymer, at least 10% by weight of an alkyl-ether sulfate, an alkoxylated polyamine, less than 30% by weight of water, and, optionally, a polyglycol. A mixture of 2 parts of the liquid detergent composition to 1 part water has a viscosity below 3,000 centipoise. | 2022-06-16 |
20220186145 | Surfactant Compositions for Improved Transparency of DADMAC-Acrylamide Co-polymers - Liquid laundry detergent compositions including a Diallyldialkylammonium Chloride (DADMAC) Acrylamide co-polymer, and a surfactant system comprising at least one non-ionic surfactant (NI) and at least one linear alkylbenzene sulfonate anionic surfactant (LAS) where the composition has a turbidity of about 50 NTUs or less. The NI is at least about 30 percent by weight of the surfactant system and the LAS is less than about 40 percent by weight of the surfactant system. The surfactant system can also include alcohol ethoxysulfate (AES). | 2022-06-16 |
20220186146 | Surfactant Compositions for Improved Transparency of DADMAC-Acrylic Acid Co-polymers - Stable and clear liquid laundry detergent compositions having a DADMAC Acrylic Acid co-polymer, a surfactant system including alcohol ethoxysulfate anionic surfactant (AES) and at least one of a linear alkyl benzene sulfonic acid anionic surfactant (LAS) and a non-ionic surfactant (NI), and an aqueous carrier. In one embodiment, the aqueous composition includes water in an amount of 30% to 80% by weight, a surfactant system in an amount of 8% to 35% by weight, and DADMAC Acrylic Acid co-polymer. The surfactant system may include: (1) at least about 40 wt % alcohol ethoxylsulfate (AES), and (2) a linear alkylbenzene sulfonate (LAS) and/or a non-ionic surfactant. The liquid compositions have a turbidity less than 50 NTUs. | 2022-06-16 |
20220186147 | LIQUID TREATMENT COMPOSITIONS COMPRISING DELIVERY PARTICLES BASED ON PLANT ROSIN MATERIAL - Liquid treatment composition that include particles and an adjunct ingredient, where the particles include a plant rosin material and one or more benefit agents. Related methods of making and using such compositions. | 2022-06-16 |
20220186148 | PROCESS OF MAKING A TREATMENT COMPOSITION THAT INCLUDES A PLANT ROSIN MATERIAL AND RELATED PREMIX COMPOSITIONS - Processes of making treatment compositions that include plant rosin materials and one or more benefit agents, such as perfume raw materials. Related premix compositions. Treatment compositions made from such processes and premixes. | 2022-06-16 |
20220186149 | TREATMENT COMPOSITIONS COMPRISING CERTAIN PLANT ROSIN MATERIALS - Treatment composition that include certain plant rosin materials and one or more benefit agents, for example fragrance materials, where the plant rosin materials are certain plant rosin esters and/or have certain characteristics, such as certain softening points, acid numbers, and/or color grades. Related methods of making and using such compositions. | 2022-06-16 |
20220186150 | ENZYMATIC POT AND PAN DETERGENT - Detergent compositions are disclosed which provide superior cleaning and removal of proteinaceous and starchy soils. Applicants have discovered a surfactant package which acts to enhance and improve the performance of enzymes such as proteases and/or amylases. Compositions for pot and pan warewash detergents and soaks are disclosed, as well as their use in manual or dish machine cleaning. | 2022-06-16 |
20220186151 | STABILIZED GLYCOSIDE HYDROLASE VARIANTS - Disclosed are variants of a glycoside hydrolase having improved stability, e.g., in the presence of a protease, and the use of such variants in detergent applications, such as laundry or dish wash. | 2022-06-16 |
20220186152 | DETERGENT COMPOSITION, SUBSTRATE CLEANING METHOD, AND CLEANING METHOD FOR SUPPORT OR SUBSTRATE - A detergent composition is a detergent composition for removing temporary adhesive containing a silicone compound that is present on a substrate. The detergent composition contains: (A) an organic solvent: 75 to 99 parts by mass; (B) water: 0 to 5 parts by mass; and (C) an ammonium salt: 1 to 20 parts by mass (where (A)+(B)+(C)=100 parts by mass). The organic solvent does not contain an organic solvent having a hydroxy group and contains, in 100 parts by mass of the organic solvent, 50 parts by mass or more of an organic solvent having a heteroatom. The ammonium salt contains at least one kind of a hydroxide ion, a fluoride ion, and a chloride ion. | 2022-06-16 |
20220186153 | LAUNDRY DETERGENT COMPOSITIONS - The invention provides a liquid laundry detergent composition having: | 2022-06-16 |
20220186154 | COMPOSITION FOR REMOVING CHEMICAL RESIDUES AND USES THEREOF - A decontamination composition with at least one primary neutralizing agent and at least one secondary neutralizing agent, for the removal of chemical residues, to a method for employing the composition, and the use of the composition for removing residues on materials, machines, and equipment soiled with chemicals of any type, such as a corrosive product or a chemical containing fluoride ions. | 2022-06-16 |
20220186155 | WATER-SOLUBLE UNIT DOSE ARTICLE - Water-soluble unit dose article and a method of making. | 2022-06-16 |
20220186156 | WATER-SOLUBLE UNIT DOSE ARTICLE - Water-soluble unit dose article and a method of making. | 2022-06-16 |
20220186157 | WATER-SOLUBLE UNIT DOSE ARTICLE - Water-soluble unit dose article comprising a laundry or automatic dishwashing detergent and a method of making. | 2022-06-16 |
20220186158 | WATER-SOLUBLE FILMS, WATER-SOLUBLE UNIT DOSE ARTICLES, AND METHODS OF MAKING AND USING THE SAME - Water-soluble films, water-soluble unit dose articles, and related methods of making and using the same. | 2022-06-16 |
20220186159 | WATER-SOLUBLE FILMS, WATER-SOLUBLE UNIT DOSE ARTICLES, AND METHODS OF MAKING AND USING THE SAME - Water-soluble films, water-soluble unit dose articles, and related methods of making and using the same. | 2022-06-16 |
20220186160 | CLEANING FORMULATION - The invention provides a method of cleaning a vehicle comprising: providing a powder composition; providing water; mixing the powder composition and the water to form a liquid cleaning formulation; and applying the liquid cleaning formulation to a surface of a vehicle, wherein the powder composition comprising: surfactant; silicate selected from magnesium lithium silicates and mixtures thereof; hygroscopic agent; at least 20 wt % carbonate salt; and at least 20 wt % acid. | 2022-06-16 |
20220186161 | PRODUCING BEER USING A WORT CONCENTRATE - Production of beer using a wort concentrate is described. In an embodiment, a system includes at least one fermentation tank comprising temperature control means. At least one processor configured to execute computer-readable instructions stored on at least one computer-readable storage media to perform a method of producing beer, including forming a mixture of a wort concentrate including hops and having a specific gravity of at least 1.085 kg/m3, with water and yeast in the fermentation tank, wherein forming the mixture comprises pumping the wort concentrate into the fermentation tank. The mixture is fermented and fermentation conditions monitored. On determining that predetermined fermentation conditions have been met, the fermented mixture is cooled to a temperature between zero and four degrees Celsius through controlling the temperature control means. The fermented mixture is carbonated, following addition of yeast finings, such that beer is produced. | 2022-06-16 |
20220186162 | METHOD AND SYSTEM FOR THE FILTRATION AND STABILIZATION OF ULTRA-HIGH GRAVITY ALCOHOLIC BEVERAGES - Methods and systems are described that filter and stabilize ultra-high gravity alcoholic beverages produced by forward osmosis. A rough ultra-high gravity alcoholic beverage may be received from a dewatering system and then passed on to a chiller as part of a post dewatering process. The ultra-high gravity alcoholic beverage may be held at a predetermined temperature for a specific amount of time such that the temperature of the ultra-high gravity alcoholic beverage is prevented from falling below a freezing point of the ultra-high gravity alcoholic beverage. The chilled ultra-high gravity alcoholic beverage is then passed through a number of filters of a filtration system. The filters may be arranged in an order progressing from coarse to fine filters, where haze compounds and their precursors are removed from the ultra-high gravity alcoholic beverage producing a clear and stable product. | 2022-06-16 |
20220186163 | DECANTER SYSTEM AND METHOD - A decanter system can include a decanter and a stopper. The decanter can include a decanter body and a neck. A mouth can be formed in the neck. The stopper can include a sealing member. The stopper can be configured to be selectively disposed in the mouth to form a seal between the sealing member and the mouth. The stopper is positionable in the mouth between a first position and a second position where the seal is maintained in each of the first position and the second position. A method of storing liquid can include providing a decanter system. A liquid can be disposed in the decanter body. A filter with flavoring materials disposed therein can be placed within the decanter body. The decanter can be sealed with the stopper in the first position. The stopper can be pushed downwards in the mouth to the second position, repeatedly as desired. | 2022-06-16 |
20220186164 | METHODS AND APPARATUSES FOR PROCESSING POULTRY LITTER - Methods, systems and apparatuses herein provide a unique and novel process to process poultry litter. In one embodiment, the poultry litter is anaerobically digested to produce a biogas and one or more nutrients. In one embodiment, the poultry litter is wettened with recycled digestate prior to anaerobic digestion. | 2022-06-16 |
20220186165 | HIGHLY DURABLE PERMEABLE FLUOROPOLYMER CELL CULTURE BAG - A cell culture bag includes a body formed of a composite film including a first fluoropolymer and a second fluoropolymer. The body defines a cell culture compartment configured to hold a cell culture. The first fluoropolymer has a first thickness and the second fluoropolymer at least partially impregnates the first thickness of the first fluoropolymer. The composite film has a second thickness from 0.01 mm to 0.059 mm and a tensile strength in one direction of 10,000 psi to 92,000 psi. The composite film also has O | 2022-06-16 |
20220186166 | SEGMENTED CULTURE DISH AND IMPRINTING SYSTEM - A segmented culture dish and imprinting system allows duplicate plates to be produced rapidly and without culture-to-culture overlap. The segmented culture dish and imprinting system includes a dish stamp, a first culture dish, and a second culture dish. The dish stamp may be placed on the first and/or the second culture dishes. The first and the second culture dishes have a key on an inside surface that ensures the orientation of cultures is always preserved, eliminating the need for markings on culture dishes. | 2022-06-16 |
20220186167 | METHOD FOR CULTIVATION OF ADHERENT CELLS IN A MULTIPARALLEL BIOREACTOR - Disclosed is a process for growing adherent cells in a containment box of a multi-parallel bioreactor, including: seeding the adherent cells on a carrier held in a culture dish; transferring the adherent cells on the carrier to a containment box of the multi-parallel bioreactor; and growing the adherent cells at a containment box while agitating the media at an impeller speed between 200 rpm to a 1200 rpm. | 2022-06-16 |
20220186168 | ROTATING SUSPENSION CULTURE DEVICES THAT ALLOW DIRECT MICROSCOPY, IN SITU ASSAYS, AND AUTOMATION - Rotating suspension culture devices that allow direct microscopy, in situ assays, and automation are disclosed. According to an aspect, a suspension culture device includes a rotatable base having an exterior surface that engages at one or more rollers for rotation of the base about an axis when the at least one roller is turning. The device includes first and second end components attached to the base along the axis. The base and the first and second end components define an interior space for holding liquid. A portion of at least one of the end components is made of a material that is at least partially transparent for viewing into the interior space from outside the base. Further, the device includes ports that each permit fluid communication between the interior space and outside the base. | 2022-06-16 |
20220186169 | POWER DEVICE OF A MICRO CHANNEL FOR EXTERNAL CIRCULATION OF A BIOREACTOR - The present disclosure provides a power device of a micro channel for external circulation of a bioreactor. The power device of the micro channel may be disposed outside the bioreactor and in fluid connection with the bioreactor, the power device of the micro channel may be of a shape of a box body. The power device of the micro channel may comprise: a stacked layer disposed in the box body, including a first shell plate, a second shell plate, and a sealing film sandwiched between the first shell plate and the second shell plate; and a liquid buffer device including a first liquid cavity and a second liquid cavity disposed in the box body, the first liquid cavity and the second liquid cavity may be fixed to an outer end surface of the stacked layer. The power device of the micro channel may be of a box shape, thereby reducing the volume and production cost thereof. | 2022-06-16 |
20220186170 | POWER DEVICE OF A MICRO CHANNEL FOR EXTERNAL CIRCULATION OF A BIOREACTOR - The present disclosure provides a power device of a micro channel for external circulation of a bioreactor. The power device of the micro channel may be disposed outside the bioreactor and in fluid connection with the bioreactor, the power device of the micro channel may be of a shape of a box body. The power device of the micro channel may comprise: a stacked layer disposed in the box body, including a first shell plate, a second shell plate, and a sealing film sandwiched between the first shell plate and the second shell plate; and a liquid buffer device including a first liquid cavity and a second liquid cavity disposed in the box body, the first liquid cavity and the second liquid cavity may be fixed to an outer end surface of the stacked layer. The power device of the micro channel may be of a box shape, thereby reducing the volume and production cost thereof. | 2022-06-16 |
20220186171 | HIGH SHEAR MIXER - Spent stillage remaining after the fermentation of a feedstock for ethanol production may be processed to recover, use, and/or recycle the constituent components of the stillage. Stillage may be mixed, heated, and held at a desired temperature for a period of time. The stillage may then be cooled and treated with an enzyme. The enzymatically treated stillage may be emulsified with oil and water, and then permitted to settle into discrete layers. Individual layers may then be processed. A system and method for separating stillage after the fermentation process of ethanol production has concluded are provided. | 2022-06-16 |
20220186172 | CELL SEPARATION APPARATUS FOR BIOREACTOR - The present disclosure provides a cell separation apparatus for a bioreactor. The cell separation apparatus may be disposed outside the bioreactor and in fluid connection with the bioreactor, the cell separation apparatus may be in a shape of a box body, the cell separation apparatus may include a liquid buffer device including a first liquid cavity disposed in the box body; a filter device including a filter channel and a filter membrane disposed in the box body, the filter membrane may be disposed above the filter channel; and a first liquid channel may be configured in the box body to facilitate a fluid communication between the first liquid cavity and the filter channel. A power system for filtering and microfluidic channels are integrated in the cell separation apparatus that is of a box shape, thereby reducing the volume and production cost thereof. | 2022-06-16 |
20220186173 | CELL SEPARATION APPARATUS FOR BIOREACTOR - The present disclosure provides a cell separation apparatus for a bioreactor. The cell separation apparatus may be disposed outside the bioreactor and in fluid connection with the bioreactor, the cell separation apparatus may be in a shape of a box body, the cell separation apparatus may include a liquid buffer device including a first liquid cavity disposed in the box body; a filter device including a filter channel and a filter membrane disposed in the box body, the filter membrane may be disposed above the filter channel; and a first liquid channel may be configured in the box body to facilitate a fluid communication between the first liquid cavity and the filter channel. A power system for filtering and microfluidic channels are integrated in the cell separation apparatus that is of a box shape, thereby reducing the volume and production cost thereof. | 2022-06-16 |
20220186174 | ACOUSTIC EDGE EFFECT - An acoustic wave with an acoustic field with a large number of multi-directional gradients can provide an edge effect that be used to form an interface region relative to the acoustic wave. The interface region can block material with certain characteristics related to the nature of the interface region. Other material that is less influenced by the acoustic properties of the interface region can pass through the acoustic wave. This technique permits separation of materials using the edge effect and interface region. | 2022-06-16 |
20220186175 | METHOD FOR CULTIVATING MICROALGAL BIOMASS AND APPARATUS FOR THE IMPLEMENTATION THEREOF - The invention relates to a process and equipment for cultivating and producing a biomass from microalgae, primarily plankton. A microalgal biomass is cultivated in a single bioreactor chamber in the shape of a vertically oriented parallelepiped. The culture mixture is illuminated by artificial light sources mounted on the inner side of one of the broad walls of the bioreactor chamber in horizontal rows throughout the height of the bioreactor chamber. The culture mixture is illuminated cyclically. Spray heads are mounted on the inner side of the opposite wall of the bioreactor chamber so that 4 spray heads are arranged symmetrically around each artificial light source. The pH value of the culture mixture is maintained in a range of 8.5-9.5 by the addition thereto of a lactic acid bacteria-containing solution at the beginning of each light cycle in an amount of 1-3 ml per litre of culture mixture, said solution having a pH value selected in a range of 4.0-5.0. | 2022-06-16 |
20220186176 | MEDIUM FOR PRIMARY ISOLATION OF PORPHYROMONAS GINGIVALIS, AND A MEDIUM FOR PREPARING THE MEDIUM AND USE THEREOF - The present disclosure discloses a medium for primary isolation of | 2022-06-16 |
20220186177 | INDUSTRIAL FERMENTATION PROCESS FOR BACILLUS USING DEFINED MEDIUM AND MAGNESIUM FEED - The present invention is directed to an industrial fermentation process for cultivating a | 2022-06-16 |
20220186178 | CELL CULTURE ARTICLE AND METHODS THEREOF - A cell culture article, including:
| 2022-06-16 |
20220186179 | METHOD FOR SEPARATING CELLS USING A STIMULUS-RESPONSIVE POLYMER - A method for separating cells may include providing a sample having at least two different types of cell, contacting the sample with a cell culture substrate comprising a stimulus-responsive polymer layer, subjecting the cell culture substrate and the cells to medium conditions to where the cells adhere to the cell culture substrate, and modifying the medium conditions to decrease the adherence of one of the cells types to the cell culture substrate. The method may further include separating the cells released from the cell culture substrate from the cells still adhered to the cell culture substrate. | 2022-06-16 |
20220186180 | METHOD OF NOCICEPTOR DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS AND USES THEREOF - The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hESC), human induced pluripotent stem cells (hiPSC), somatic stem cells, cancer stem cells, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hESC and/or hiPSC to nociceptors (i.e. nociceptor cells) using novel culture conditions. The nociceptors made using the methods of the present invention are further contemplated for various uses including, but limited to, use in in vitro drug discovery assays, pain research, and as a therapeutic to reverse disease of, or damage to, the peripheral nervous system (PNS). Further, compositions and methods are provided for producing melanocytes from human pluripotent stem cells for use in disease modeling. | 2022-06-16 |
20220186181 | CULTURE MEDIUM FOR EXPANDING AND CULTURING HUMAN LIVER PROGENITOR CELLS AND APPLICATION THEREOF - Provided are a culture medium for expanding and cultivating human liver progenitor cells and an application thereof. The chemical components of the formula of the described culture medium are clear, no serum is present, and various components thereof cooperate with each other to synergize. The culture medium is used for the long-term expansion and cultivation of liver progenitor cells in vitro and is used for maintaining the dryness thereof, is beneficial in quickly and efficiently obtaining a large number of functional liver cells, and is suitable for clinical hepatocyte transplantation application as well as for the use of hepatocyte reactors in bioartificial livers. | 2022-06-16 |
20220186183 | NOVEL GLIA-LIKE CELLS DIFFERENATIATED FROM SOMATIC CELLS, PREPARATION METHOD THEREFOR, COCKTAIL COMPOSITION FOR PREPARING SAME, CELL THERAPEUTIC AGENT FOR PREVENTING OR TREATING NEUROLOGICAL DISORDERS, COMPRISING SAME, AND METHOD FOR PREVENTING AND TREATING NEUROLOGICAL DISORDERS BY ADMINISTERING SAME - The present disclosure relates to novel glia-like cells that are differentiated from somatic cells and secrete 20,000 pg/ml or more of HGF, a chemical cocktail composition for producing the same, a method for producing the same, a cell therapy product for treating neurological disorder containing the same, and a method of preventing and treating neurological disorder by administering the same. | 2022-06-16 |
20220186184 | COMPOSITIONS AND METHODS OF EXPANSION OF T CELL POPULATIONS - The present disclosure generally relates to compositions and methods useful for an adoptive cell therapy. Some embodiments of the disclosure relates to methods for producing a population of lymphocytes enriched in T stem cell memory cells (T | 2022-06-16 |
20220186185 | METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY - An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm | 2022-06-16 |
20220186186 | COMPOSITION FOR INDUCING DIRECT CONVERSION OF SOMATIC CELL INTO COMMON MYELOID PROGENITOR AND USE THEREOF - Provided are: a composition for inducing direct conversion from somatic cells into common myeloid progenitor cells, the composition including a chemical cocktail; a method of direct conversion of somatic cells into common myeloid progenitor cells and macrophages by using the composition; common myeloid progenitor cells or macrophages prepared by the method; a pharmaceutical composition for preventing or treating fibrosis or scars, cell therapeutics, a composition for screening drugs, and a 3D printable biomaterial composition for fabricating artificial tissues, each using the common myeloid progenitor cells or the macrophages. | 2022-06-16 |
20220186187 | COMPOSITIONS AND METHODS FOR EXTRACTION OF MESENCHYMAL STEM CELLS - Compositions and methods for the extraction mesenchymal cells from deceased donor bone, and therapeutic applications thereof, along with combination therapeutic applications comprising mesenchymal cells from deceased donors and bone marrow derived from deceased donors are presented. | 2022-06-16 |
20220186188 | Method for Obtaining Pancreatic Progenitor Cells and Pancreatic Islet Beta Cells By Means of Differentiation of Human Pluripotent Stem Cells - Provided is a method for obtaining pancreatic precursor cells and islet β cells by differentiation of human pluripotent stem cells by adding a WNT signaling pathway inhibitor into the process of specialization of endoderm cells derived from human pluripotent stem cells into pancreatic lineage cells. | 2022-06-16 |
20220186189 | METHOD FOR INDUCING DIFFERENTIATION OF ALVEOLAR EPITHELIAL CELLS - This invention provides a method for stably producing type II alveolar epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing type II alveolar epithelial cells from pluripotent stem cells comprising steps of: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3β inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGFβ inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3β inhibitor; (4) culturing the ventral anterior foregut cells obtained in Step (3) in a medium containing a GSK3β inhibitor, FGF10, KGF, and a NOTCH signal inhibitor; and (5) subjecting the alveolar epithelial progenitor cells obtained in Step (4) to three-dimensional culture in a medium containing a steroid drug, a cAMP derivative, a phosphodiesterase inhibitor, and KGF. | 2022-06-16 |
20220186190 | MODELING ONCOLOGY ON DEMAND - Genetically modified pigs having at least one cancer and/or at least one co-morbid condition are provided. Also provided are methods of using the pig and derived tumor cells to screen for therapeutic compounds, medical devices or procedures, and/or combinations thereof. Further provided are methods of producing personalized cancer models, including obtaining a tumor sample from a subject, identifying mutations in the tumor sample, and producing a genetically modified tumor or tumor cell line having the same mutations. | 2022-06-16 |
20220186191 | SERUM-FREE MEDIUM FOR AVIAN VACCINE PRODUCTION AND USES THEREOF - The present disclosure relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium supplemented with peptides and peptones derived from plant or vegetable sources. The method for the cultivation of primary cells may be one step in a method for the amplification of viruses, such as poxviruses. | 2022-06-16 |
20220186192 | VACCINIA VIRUS MUTANTS USEFUL FOR CANCER IMMUNOTHERAPY - Disclosed herein are methods and compositions related to the treatment, prevention, and/or amelioration of cancer in a subject in need thereof. In particular aspects, the present technology relates to the use of poxviruses, including a recombinant modified vaccinia Ankara (MVA) virus or vaccinia virus with deletion of vaccinia host-range factor C7 (MVAΔC7L and VACVΔC7L, respectively), alone or in combination with immune checkpoint blocking agents, as an oncolytic and immunotherapeutic composition. In some embodiments, the technology of the present disclosure relates to a MVAΔC7L or VACVΔC7L virus further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L). | 2022-06-16 |
20220186193 | METHODS AND COMPOSITIONS FOR IMPROVING THE ASSEMBLY OF ADENO-ASSOCIATED VIRUSES (AAVs) - Described herein are methods and compositions for modifying cells to improve the assembly of adeno-associated viruses (AAVs). | 2022-06-16 |
20220186194 | METHODS OF PURIFYING ADENOVIRUS - Methods of purifying adenovirus that can be performed on a large scale. The methods purify adenovirus from an adenovirus-containing sample comprising or derived from a host cell population by clarifying the sample, wherein clarification comprises depth filtration followed by microfiltration; processing the clarified sample by anion exchange chromatography; and processing the anion exchange product by tangential flow filtration (TFF) to provide a TFF product. | 2022-06-16 |
20220186195 | GLUCURONOSYLTRANSFERASE, GENE ENCODING SAME AND USE THEREOF - Provided are an enzyme involved in a glycyrrhizin biosynthetic system, a gene of the enzyme and use thereof in order to stably and continuously provide a large amount of glycyrrhizin. Glucuronosyltransferase with an activity of further transferring glucuronic acid to the hydroxy group at the 2-position of glucuronic acid in an oleanane-type triterpenoid monoglucuronide is identified to provide the transferase, a gene for the transferase and use thereof. | 2022-06-16 |
20220186196 | Methods of Host Cell Modification - Described herein are methods of inserting nucleic acid sequences into host cells. Also described herein are genetically stable host cells comprising inserted nucleic acid sequences and methods of using such host cells in the generation of proteins. | 2022-06-16 |
20220186197 | T7 RNA POLYMERASE VARIANTS - The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts. | 2022-06-16 |
20220186198 | TCRa HOMING ENDONUCLEASE VARIANTS - The present disclosure provides improved genome editing compositions and methods for editing a TCRα gene. | 2022-06-16 |
20220186199 | CAS9 FUSION MOLECULES, GENE EDITING SYSTEMS, AND METHODS OF USE THEREOF - Disclosed herein are enzymatically active Cas9 (eaCas9) fusion molecules, comprising an eaCas9 molecule linked, e.g., covalently or non-covalently, to a template nucleic acid; gene editing systems comprising the eaCas9 fusion molecules, and methods of use thereof. | 2022-06-16 |
20220186200 | AMYLASES AND METHODS FOR MAKING AND USING THEM - Variant polypeptides having G4-amylase activity and methods of making and using the enzymes in baking, detergents, personal care products, in the processing of textiles, in pulp and paper processing, in the production of ethanol, lignocellulosic ethanol, or syrups; or as viscosity breakers in oilfield and mining industries. | 2022-06-16 |
20220186201 | METHOD OF PURIFYING BOTULINUM TOXIN - Disclosed is a method of purifying a botulinum toxin including (a) pre-treating a culture solution containing a botulinum toxin, (b) purifying the pre-treated botulinum toxin using anion exchange chromatography and (c) purifying the botulinum toxin using cation exchange chromatography. The method is capable of purifying a botulinum toxin with high purity and activity using a simple process including anion exchange chromatography and cation exchange chromatography, and is thus useful for botulinum toxin production. | 2022-06-16 |
20220186202 | CARBONIC ANHYDRASE VARIANTS FOR IMPROVED CO2 CAPTURE - Recombinant carbonic anhydrase variants having improved solubility and/or thermostability for enzyme-enhanced CO2 capture are provided. Host cells, methods, and processes relating to same are also provided. | 2022-06-16 |
20220186203 | ENDOGLUCANASE VARIANTS WITH IMPROVED PROPERTIES - The present invention relates to endoglucanase variants with improved properties and uses thereof as eco-friendly biocatalysts in various industrial processes. More in particular the invention provides a polypeptide with endoglucanase activity (EC 3.2.1.4) comprising an amino acid sequence that is at least 90% identical to the amino acid sequence according to SEQ ID NO: 1 or SEQ ID NO: 2, wherein the polypeptide comprises an amino acid selected from the group consisting of Glycine, Threonine, Serine, Alanine, Leucine, Isoleucine and Valine at a position corresponding to position 579 in SEQ ID NO: 1 or SEQ ID NO: 2 or an amino acid selected from the group consisting of Serine, Alanine and Valine at a position corresponding to position 656 in SEQ ID NO: 1 or SEQ ID NO: 2. | 2022-06-16 |
20220186204 | IMMOBILIZED THERMOSTABLE TREHALOSE SYNTHASE AND METHOD FOR PRODUCING TREHALOSE AND TREHALULOSE BY USING SAME - Provided is an immobilized thermostable trehalose synthase including an amino acid sequence of a trehalose synthase domain and an amino acid sequence of a cellulose binding domain. Also provided is a method for converting maltose into trehalose or for converting sucrose into trehalulose by using the immobilized thermostable trehalose synthase. | 2022-06-16 |
20220186205 | DPO4 POLYMERASE VARIANTS - Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes. | 2022-06-16 |
20220186206 | NOVEL Cas ENZYME AND SYSTEM, AND USE THEREOF - A CRISPR-associated (Cas) protein, a fusion protein including the Cas protein, and a nucleic acid encoding either of the proteins are provided. The Cas protein is any one from the group consisting of a Cas protein having an amino acid sequence with at least 95% sequence identity with SEQ ID NO: 1 and basically retaining a biological function of SEQ ID NO: 1; a Cas protein having an amino acid sequence obtained through a substitution, a deletion, or an addition of one or more amino acids based on SEQ ID NO: 1 and basically retaining the biological function of SEQ ID NO: 1; and a Cas protein comprising an amino acid sequence shown in SEQ ID NO: 1. | 2022-06-16 |